CN110051716A - A kind of Chinese materia medica preparation and preparation method thereof for treating amblyopia - Google Patents
A kind of Chinese materia medica preparation and preparation method thereof for treating amblyopia Download PDFInfo
- Publication number
- CN110051716A CN110051716A CN201910498009.2A CN201910498009A CN110051716A CN 110051716 A CN110051716 A CN 110051716A CN 201910498009 A CN201910498009 A CN 201910498009A CN 110051716 A CN110051716 A CN 110051716A
- Authority
- CN
- China
- Prior art keywords
- preparation
- amblyopia
- materia medica
- added
- chinese materia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to ophthalmology technical field of Chinese medicine, disclose a kind of Chinese materia medica preparation and preparation method thereof for treating amblyopia.The Chinese materia medica preparation is prepared by choosing resourceful Chinese medicine, and is clinically applied.Medicinal material in the Chinese materia medica preparation complements each other, compatibility is proper, effectively strengthen mutual fusion and the effect between each medicinal material, thus nutrition, alleviation eye strain needed for reaching dredging eye channels and collaterals, transferring eye qi and blood, supplement eye, at the same time, development of vision system is effectively facilitated, enhance the sensitivity of visual cell, activate and repaired the activity of eye damaged cell and degenerated cell, improve the microcirculation of eye, it has been obviously improved eyesight, there is high curative effect to amblyopia, achieve the purpose that treat amblyopia from the root.The preparation method operating process of the medicament is simple, of less demanding to operator and low in cost.Without any side effects, the individual suitable for each age group of the invention.
Description
Technical field
The invention belongs to ophthalmology technical field of Chinese medicine, and in particular to a kind of for treating the Chinese materia medica preparation and its system of amblyopia
Preparation Method.
Background technique
Amblyopia is one kind since eyeball is without significant organic pathology, and still up to not after causing simple eye or eyes to be corrected defects of vision
People to 0.9 is amblyopia.Amblyopia can be divided into four class of three-level as a kind of common disease for seriously affecting children's vision.Three-level
Be be divided by degree it is light, in, weight three-level, four classes are to be divided into strabismic amblyopia, anisometropic amblyopia, ametropic by the cause of disease
Four class of amblyopia and form deprivation amblyopia.Children's myopia is mainly caused by factors such as strabismus, ametropia, antimetropias, so that
Light image cannot clearly be imaged on the retina, cause retina visual cell, visual conduction path nerve and visual centre mind
Through equal functional developments exception or taking off of cell.Children with amblyopia not only weak-eyed, and not with visual function and stereoscopic vision function,
The development, study and normal life of children are seriously affected, or even influences the physical and mental health of children.The treatment best age of amblyopia is
Before 6 years old, if early discovery early treatment, 98% infant can cure.
The clinical manifestation of amblyopia is mainly eyesight and ametropia, point reading is difficult or is in crowding phenomenon.Chinese medicine thinks amblyopia
Mostly due to native endowment deficiency, the day after tomorrow taste dystrophy cause vital essence cannot on hold and support in mesh, imbalance of yin and yang, loss of nutrient of eyes, mind
Light hair is more incompetent, leads to low vision.
Currently, treatment amblyopia generallys use Dai Jing, covering, pleoptic therapy, the course for the treatment of is long, and eyesight is easy to retract.Doctor trained in Western medicine is normal
It is levodopa with drug, there are certain side effects.
Summary of the invention
In order to solve the above problems existing in the present technology, it is an object of that present invention to provide a kind of for treating in amblyopia
Medicine preparation and preparation method thereof.
The technical scheme adopted by the invention is as follows: it is a kind of for treating the Chinese materia medica preparation of amblyopia, the Chinese materia medica preparation mainly by
The raw material of following mass fraction is prepared:
10-100 parts of pot marigold, 10-90 parts of ginkgo leaf, 10-80 parts of Radix Malvae sylvestris flower, 3-50 parts of hamamelis and ginseng
10-98 parts.
Preferably, Chinese materia medica preparation is mainly prepared by the raw material of following mass fraction:
30-50 parts of pot marigold, 28-40 parts of ginkgo leaf, 15-35 parts of Radix Malvae sylvestris flower, 8-28 parts of hamamelis and ginseng 45-
60 parts.
Preferably, Chinese materia medica preparation is mainly prepared by the raw material of following mass fraction:
35 parts of pot marigold, 30 parts of ginkgo leaf, Radix Malvae sylvestris spend 20 parts, 10 parts of hamamelis and 50 parts of ginseng.
The Chinese materia medica preparation provided by the invention is prepared by choosing resourceful Chinese medicine, and is clinically obtained
Using.Medicinal material in the Chinese materia medica preparation complements each other, compatibility is proper, effectively strengthens the mutual fusion between each medicinal material and makees
With, thus nutrition, alleviation eye strain needed for reaching dredging eye channels and collaterals, transferring eye qi and blood, supplement eye, at the same time,
Development of vision system has been effectively facilitated, the sensitivity of visual cell is enhanced, activate and repaired eye damaged cell and has been degenerated thin
The activity of born of the same parents improves the microcirculation of eye, has been obviously improved eyesight, has high curative effect to amblyopia, reaches from the root
The purpose for treating amblyopia.
It is a kind of for treating the preparation method of the Chinese materia medica preparation of amblyopia, which includes the following steps:
(1) drying and dehydrating: after weighing pot marigold, ginkgo leaf, Radix Malvae sylvestris flower, hamamelis and ginseng according to corresponding proportion
Mixing is dried and dehydrated；
(2) it crushes, impregnate and heat: being mixed after the raw material after drying and dehydrating in step (1) are crushed, to mixing
Solvent soaking is added in raw material and heats, obtains stoste extract；
(3) extracting solutions；Organic solvent is added into stoste extract obtained in step (2), after stirring again into
Row heating, obtains an extracting solution；
(4) secondary raffinate: desiccant is added into an extracting solution obtained in step (3), obtains secondary raffinate；
(5) extracting solution three times: solvent is added into secondary raffinate obtained in step (4), obtains extracting solution three times；
(6) it rinses: by extracting solution crystallizes three times obtained in step (5), rinsing crystal, obtain head product；
(7) finished product is made: after head product obtained in step (6) is dried finished product is made.
The preparation method operating process of the medicament is simple, of less demanding to operator and low in cost.The present invention without appoint
What toxic side effect, the individual suitable for each age group.
Preferably, it includes any one in water, ethyl alcohol or n-hexane that solvent is added in step (2).
Preferably, heating temperature is 20-80 degrees Celsius in step (2)；
Preferably, heating temperature is 30-65 degrees Celsius；
It is further preferred that institute's heating temperature is 60 degrees Celsius.
The Chinese materia medica preparation provided by the invention using the raw material of water, ethyl alcohol or n-hexane equal solvent to Chinese medicine by being carried out
Impregnate and heat, be for raw material obtain sufficiently impregnate after, using vacuum distillation method in raw material it is effective at
Divide and is purified.Aquation extract, alcoholization extract or esterification extract etc. can be obtained efficiently in the process, to obtain original
Liquid extract.Setting to temperature is for reducing energy consumption to the maximum extent on the basis of can reach extraction process.
Preferably, it includes any one in Propylene Glycol or ethyl alcohol that organic solvent is added in step (3).
Preferably, the desiccant being added in step (4) includes in potassium hydroxide, calcium hydroxide, quick lime or soda lime
Any one.
Preferably, the solvent being added in step (5) includes water, and amount of water and weighed medicinal material total quality ratio are 25-65:3-
8；
Preferably, amount of water and weighed medicinal material total quality ratio are 30-40:5-6.5.
Preferably, step (7) drying temperature is 10-40 degrees Celsius；Drying time is 12-72 hours；
Preferably, drying temperature is 20-30 degrees Celsius；Drying time is 24-55 hours；
It is further preferred that drying temperature is 25 degrees Celsius；Drying time is 48 hours.
The invention has the benefit that
The invention discloses a kind of Chinese materia medica preparations and preparation method thereof for treating amblyopia.The Chinese materia medica preparation passes through selection
Prepared by resourceful Chinese medicine, and be clinically applied.Medicinal material in the Chinese materia medica preparation complements each other, compatibility obtains
When, effectively strengthen between each medicinal material it is mutual fusion and effect, thus reach dredging eye channels and collaterals, transfer eye qi and blood, mend
Fill nutrition needed for eye, alleviate eye strain effectively facilitated development of vision system at the same time, enhance the spirit of visual cell
Sensitivity activates and has repaired the activity of eye damaged cell and degenerated cell, improves the microcirculation of eye, has been obviously improved view
Power has high curative effect to amblyopia, achievees the purpose that treat amblyopia from the root.The preparation method operating process letter of the medicament
It is single, of less demanding to operator and low in cost.Without any side effects, the individual suitable for each age group of the invention.
Specific embodiment
Further explaination is done to the present invention combined with specific embodiments below.It will be understood to those of skill in the art that following institute
The embodiment of description is that a part of the embodiment of the present invention is merely to illustrate the present invention instead of all the embodiments, without that should regard
To limit the scope of the invention.Based on the embodiments of the present invention, those of ordinary skill in the art are not making creative labor
Every other embodiment obtained under the premise of dynamic, shall fall within the protection scope of the present invention.Actual conditions are not specified in embodiment
Person carries out according to normal conditions.Agents useful for same is the conventional products that can be obtained by commercially available purchase.
Embodiment 1:
It chooses and weighs 10 grams of pot marigold, 10 grams of ginkgo leaf, Radix Malvae sylvestris spends 10 grams, 3 grams and 10 grams of ginseng of hamamelis
Mixing, which is put into baking oven, afterwards is dried and is dehydrated.Above-mentioned raw material after drying and dehydrating are put into pulverizer to crush, it will
Smashed above-mentioned raw material powder is uniformly mixed and is put into container.Backward container in n-hexane be added impregnate, impregnate 1 small
When after heated, continue after being heated to 20 degrees Celsius after ten minutes, obtain esterification extract.First is added in stoste extract
Ethyl glycol is again heated to 35 degrees Celsius after mixing evenly, obtains an extracting solution.After extracting solution is heated 15 minutes,
It is slowly added to potassium hydroxide (45mol/mL) aqueous solution, is stirred while potassium hydroxide aqueous solution is added and measures temperature
Degree when the temperature of secondary raffinate to be obtained is maintained at 50 degrees Celsius, that is, stops that potassium hydroxide is added, obtains second extraction
Liquid.Secondary raffinate is put into insulating box and is saved 5 hours.Backward secondary raffinate in be added 258 grams of distilled water, stirring is equal
It is even, obtain extracting solution three times.It extracting solution will be put into centrifuge tube, be crystallized after selecting centrifuge to be centrifuged three times.
It is crystallized with 85 degrees Celsius of distilled water flow wash, carries out the removal of organic solvent and desiccant residue, washing time 0.5
A hour obtains head product after flushing.Head product is dried in vacuo, drying temperature is 10 degrees Celsius, and holding 12 is small
When, that is, finished product is made.
Embodiment 2:
It chooses and weighs 10 grams of pot marigold, 10 grams of ginkgo leaf, Radix Malvae sylvestris spends 10 grams, 3 grams and 10 grams of ginseng of hamamelis
Mixing, which is put into baking oven, afterwards is dried and is dehydrated.Above-mentioned raw material after drying and dehydrating are put into pulverizer to crush, it will
Smashed above-mentioned raw material powder is uniformly mixed and is put into container.Backward container in n-hexane be added impregnate, impregnate 3 small
When after heated, after continuing 45 minutes after being heated to 80 degrees Celsius, obtain esterification extract.First is added in esterification extract
Ethyl glycol is again heated to 100 degrees Celsius after mixing evenly, obtains an extracting solution.Extracting solution is heated 45 minutes
Afterwards, it is slowly added to potassium hydroxide (45mol/mL) aqueous solution, is stirred and measures while potassium hydroxide aqueous solution is added
Temperature when the temperature of secondary raffinate to be obtained is maintained at 120 degrees Celsius, that is, stops that potassium hydroxide is added, obtains secondary mention
Take liquid.It is put into insulating box and saves 18 hours.Backward secondary raffinate in be added 258 grams of distilled water, stir evenly, obtain three
Secondary extracting solution.It extracting solution will be put into centrifuge tube, be crystallized after selecting centrifuge to be centrifuged three times.With 85 degrees Celsius
Distilled water flow wash crystallization, carry out organic solvent and desiccant residue removal, washing time be 4 hours, rinse
After obtain head product.Head product is dried in vacuo, drying temperature is 40 degrees Celsius, is kept for 72 hours, that is, is made into
Product.
Embodiment 3:
It chooses and weighs 100 grams of pot marigold, 90 grams of ginkgo leaf, Radix Malvae sylvestris spends 80 grams, 50 grams of hamamelis and ginseng 98
Mixing, which is put into baking oven, after gram is dried and is dehydrated.Above-mentioned raw material after drying and dehydrating are put into pulverizer to crush,
Smashed above-mentioned raw material powder is uniformly mixed and is put into container.Backward container in be added n-hexane impregnate, impregnate 1
It is heated after hour, continues after ten minutes, to obtain esterification extract after being heated to 20 degrees Celsius.It is added in stoste extract
Propylene Glycol is again heated to 35 degrees Celsius after mixing evenly, obtains an extracting solution.Extracting solution is heated 15 minutes
Afterwards, it is slowly added to potassium hydroxide (45mol/mL) aqueous solution, is stirred and measures while potassium hydroxide aqueous solution is added
Temperature when the temperature of secondary raffinate to be obtained is maintained at 50 degrees Celsius, that is, stops that potassium hydroxide is added, obtains second extraction
Liquid.Secondary raffinate is put into insulating box and is saved 5 hours.Backward secondary raffinate in be added 3344 grams of distilled water, stirring
Uniformly, extracting solution three times is obtained.It extracting solution will be put into centrifuge tube, be tied after selecting centrifuge to be centrifuged three times
It is brilliant.It is crystallized with 85 degrees Celsius of distilled water flow wash, carries out the removal of organic solvent and desiccant residue, washing time is
0.5 hour, head product is obtained after flushing.Head product is dried in vacuo, drying temperature is 10 degrees Celsius, keeps 12
Hour, that is, finished product is made.
Embodiment 4:
It chooses and weighs 100 grams of pot marigold, 90 grams of ginkgo leaf, Radix Malvae sylvestris spends 80 grams, 50 grams of hamamelis and ginseng 98
Mixing, which is put into baking oven, after gram is dried and is dehydrated.Above-mentioned raw material after drying and dehydrating are put into pulverizer to crush,
Smashed above-mentioned raw material powder is uniformly mixed and is put into container.Backward container in be added n-hexane impregnate, impregnate 3
It is heated after hour, after continuing 45 minutes after being heated to 80 degrees Celsius, obtains esterification extract.It is added in esterification extract
Propylene Glycol is again heated to 100 degrees Celsius after mixing evenly, obtains an extracting solution.Extracting solution is heated 45 minutes
Afterwards, it is slowly added to potassium hydroxide (45mol/mL) aqueous solution, is stirred and measures while potassium hydroxide aqueous solution is added
Temperature when the temperature of secondary raffinate to be obtained is maintained at 120 degrees Celsius, that is, stops that potassium hydroxide is added, obtains secondary mention
Take liquid.It is put into insulating box and saves 18 hours.Backward secondary raffinate in be added 3344 grams of distilled water, stir evenly, obtain
Extracting solution three times.It extracting solution will be put into centrifuge tube, be crystallized after selecting centrifuge to be centrifuged three times.It is Celsius with 85
The distilled water flow wash of degree crystallizes, and carries out the removal of organic solvent and desiccant residue, and washing time is 4 hours, punching
Head product is obtained after washing.Head product is dried in vacuo, drying temperature is 40 degrees Celsius, is kept for 72 hours, that is, is made
Finished product.
Embodiment 5:
It chooses and weighs 30 grams of pot marigold, 28 grams of ginkgo leaf, Radix Malvae sylvestris spends 15 grams, 8 grams and 45 grams of ginseng of hamamelis
Mixing, which is put into baking oven, afterwards is dried and is dehydrated.Above-mentioned raw material after drying and dehydrating are put into pulverizer to crush, it will
Smashed above-mentioned raw material powder is uniformly mixed and is put into container.Backward container in be added n-hexane impregnate, impregnate 1.5
It is heated after hour, continues after twenty minutes, to obtain esterification extract after being heated to 30 degrees Celsius.It is added in esterification extract
Propylene Glycol is again heated to 45 degrees Celsius after mixing evenly, obtains an extracting solution.Extracting solution is heated 20 minutes
Afterwards, it is slowly added to potassium hydroxide (45mol/mL) aqueous solution, is stirred and measures while potassium hydroxide aqueous solution is added
Temperature when the temperature of secondary raffinate to be obtained is maintained at 60 degrees Celsius, that is, stops that potassium hydroxide is added, obtains second extraction
Liquid.It is put into insulating box and saves 8 hours.Backward secondary raffinate in be added 756 grams of distilled water, stir evenly, obtain three times
Extracting solution.It extracting solution will be put into centrifuge tube, be crystallized after selecting centrifuge to be centrifuged three times.With 85 degrees Celsius
The crystallization of distilled water flow wash carries out the removal of organic solvent and desiccant residue, and washing time is 1 hour, rinses knot
Head product is obtained after beam.Head product is dried in vacuo, drying temperature is 20 degrees Celsius, is kept for 24 hours, that is, finished product is made.
Embodiment 6:
It chooses and weighs 30 grams of pot marigold, 28 grams of ginkgo leaf, Radix Malvae sylvestris spends 15 grams, 8 grams and 45 grams of ginseng of hamamelis
Mixing, which is put into baking oven, afterwards is dried and is dehydrated.Above-mentioned raw material after drying and dehydrating are put into pulverizer to crush, it will
Smashed above-mentioned raw material powder is uniformly mixed and is put into container.Backward container in be added n-hexane impregnate, impregnate 2.5
It is heated after hour, after continuing 35 minutes after being heated to 60 degrees Celsius, obtains esterification extract.It is added in esterification extract
Propylene Glycol is again heated to 70 degrees Celsius after mixing evenly, obtains an extracting solution.Extracting solution is heated 35 minutes
Afterwards, it is slowly added to potassium hydroxide (45mol/mL) aqueous solution, is stirred and measures while potassium hydroxide aqueous solution is added
Temperature when the temperature of secondary raffinate to be obtained is maintained at 90 degrees Celsius, that is, stops that potassium hydroxide is added, obtains second extraction
Liquid.It is put into insulating box and saves 12 hours.Backward secondary raffinate in be added 756 grams of distilled water, stir evenly, obtain three times
Extracting solution.It extracting solution will be put into centrifuge tube, be crystallized after selecting centrifuge to be centrifuged three times.With 85 degrees Celsius
The crystallization of distilled water flow wash carries out the removal of organic solvent and desiccant residue, and washing time is 3 hours, rinses knot
Head product is obtained after beam.Head product is dried in vacuo, drying temperature is 30 degrees Celsius, is kept for 55 hours, that is, finished product is made.
Embodiment 7:
It chooses and weighs 50 grams of pot marigold, 40 grams of ginkgo leaf, Radix Malvae sylvestris spends 35 grams, 28 grams and 60 grams of ginseng of hamamelis
Mixing, which is put into baking oven, afterwards is dried and is dehydrated.Above-mentioned raw material after drying and dehydrating are put into pulverizer to crush, it will
Smashed above-mentioned raw material powder is uniformly mixed and is put into container.Backward container in be added n-hexane impregnate, impregnate 1.5
It is heated after hour, continues after twenty minutes, to obtain esterification extract after being heated to 30 degrees Celsius.It is added in esterification extract
Propylene Glycol is again heated to 45 degrees Celsius after mixing evenly, obtains an extracting solution.Extracting solution is heated 20 minutes
Afterwards, it is slowly added to potassium hydroxide (45mol/mL) aqueous solution, is stirred and measures while potassium hydroxide aqueous solution is added
Temperature when the temperature of secondary raffinate to be obtained is maintained at 60 degrees Celsius, that is, stops that potassium hydroxide is added, obtains second extraction
Liquid.It is put into insulating box and saves 8 hours.Backward secondary raffinate in be added 1704 grams of distilled water, stir evenly, obtain three times
Extracting solution.It extracting solution will be put into centrifuge tube, be crystallized after selecting centrifuge to be centrifuged three times.With 85 degrees Celsius
The crystallization of distilled water flow wash carries out the removal of organic solvent and desiccant residue, and washing time is 1 hour, rinses knot
Head product is obtained after beam.Head product is dried in vacuo, drying temperature is 20 degrees Celsius, is kept for 24 hours, that is, finished product is made.
Embodiment 8:
It chooses and weighs 50 grams of pot marigold, 40 grams of ginkgo leaf, Radix Malvae sylvestris spends 35 grams, 28 grams and 60 grams of ginseng of hamamelis
Mixing, which is put into baking oven, afterwards is dried and is dehydrated.Above-mentioned raw material after drying and dehydrating are put into pulverizer to crush, it will
Smashed above-mentioned raw material powder is uniformly mixed and is put into container.Backward container in be added n-hexane impregnate, impregnate 2.5
It is heated after hour, after continuing 35 minutes after being heated to 60 degrees Celsius, obtains esterification extract.It is added in esterification extract
Propylene Glycol is again heated to 70 degrees Celsius after mixing evenly, obtains an extracting solution.Extracting solution is heated 35 minutes
Afterwards, it is slowly added to potassium hydroxide (45mol/mL) aqueous solution, is stirred and measures while potassium hydroxide aqueous solution is added
Temperature when the temperature of secondary raffinate to be obtained is maintained at 90 degrees Celsius, that is, stops that potassium hydroxide is added, obtains second extraction
Liquid.It is put into insulating box and saves 12 hours.Backward secondary raffinate in be added 1704 grams of distilled water, stir evenly, obtain three
Secondary extracting solution.It extracting solution will be put into centrifuge tube, be crystallized after selecting centrifuge to be centrifuged three times.With 85 degrees Celsius
Distilled water flow wash crystallization, carry out organic solvent and desiccant residue removal, washing time be 3 hours, rinse
After obtain head product.Head product is dried in vacuo, drying temperature is 30 degrees Celsius, is kept for 55 hours, that is, is made into
Product.
Embodiment 9:
It chooses and weighs 35 grams of pot marigold, 30 grams of ginkgo leaf, Radix Malvae sylvestris spends 20 grams, 10 grams and 50 grams of ginseng of hamamelis
Mixing, which is put into baking oven, afterwards is dried and is dehydrated.Above-mentioned raw material after drying and dehydrating are put into pulverizer to crush, it will
Smashed above-mentioned raw material powder is uniformly mixed and is put into container.Backward container in be added n-hexane impregnate, impregnate 2.5
It is heated after hour, after continuing 30 minutes after 60 degrees Celsius of heating, obtains esterification extract.First is added in esterification extract
Ethyl glycol is again heated to 55 degrees Celsius after mixing evenly, obtains an extracting solution.After extracting solution is heated 30 minutes,
It is slowly added to potassium hydroxide (45mol/mL) aqueous solution, is stirred while potassium hydroxide aqueous solution is added and measures temperature
Degree when the temperature of secondary raffinate to be obtained is maintained at 70 degrees Celsius, that is, stops that potassium hydroxide is added, obtains second extraction
Liquid.It is put into insulating box and saves 11 hours.Backward secondary raffinate in be added 870 grams of distilled water, stir evenly, obtain three times
Extracting solution.It extracting solution will be put into centrifuge tube, be crystallized after selecting centrifuge to be centrifuged three times.With 85 degrees Celsius
The crystallization of distilled water flow wash carries out the removal of organic solvent and desiccant residue, and washing time is 2 hours, rinses knot
Head product is obtained after beam.Head product is dried in vacuo, drying temperature is 25 degrees Celsius, is kept for 48 hours, that is, finished product is made.
Embodiment 10:
It chooses and weighs 35 grams of pot marigold, 30 grams of ginkgo leaf, Radix Malvae sylvestris spends 20 grams, 10 grams and 50 grams of ginseng of hamamelis
Mixing, which is put into baking oven, afterwards is dried and is dehydrated.Above-mentioned raw material after drying and dehydrating are put into pulverizer to crush, it will
Smashed above-mentioned raw material powder is uniformly mixed and is put into container.Backward container in n-hexane be added impregnate, impregnate 2 small
When after heated, after continuing 35 minutes after being heated to 55 degrees Celsius, obtain esterification extract.First is added in esterification extract
Ethyl glycol is again heated to 50 degrees Celsius after mixing evenly, obtains an extracting solution.After extracting solution is heated 30 minutes,
It is slowly added to potassium hydroxide (45mol/mL) aqueous solution, is stirred while potassium hydroxide aqueous solution is added and measures temperature
Degree when the temperature of secondary raffinate to be obtained is maintained at 70 degrees Celsius, that is, stops that potassium hydroxide is added, obtains second extraction
Liquid.It is put into insulating box and saves 10 hours.Backward secondary raffinate in be added 1160 grams of distilled water, stir evenly, obtain three
Secondary extracting solution.It extracting solution will be put into centrifuge tube, be crystallized after selecting centrifuge to be centrifuged three times.With 85 degrees Celsius
Distilled water flow wash crystallization, carry out organic solvent and desiccant residue removal, washing time be 3 hours, rinse
After obtain head product.Head product is dried in vacuo, drying temperature is 25 degrees Celsius, is kept for 48 hours, that is, is made into
Product.
Experimental example
30 eyes are randomly selected with amblyopia, the young age youngster that physical condition is good, the age is between 3-7 (comprising 7) years old
Child is used as experimental subjects, and above-mentioned 30 child patients are divided into 3 groups, and every group 10, wherein the amblyopia situation of every group of child patient point
Cloth is uniform.The Chinese materia medica preparation for the treatment amblyopia being prepared in the various embodiments described above respectively tries each group experimental subjects
It tests and monitors.First group of 10 experimental subjects are numbered: 1-10, the experimental subjects after each number use this product phase
Corresponding embodiment, remaining 2 groups of fortune carry out the distribution and use of embodiment, the overall effect of 3 groups of observation in the same way.Often
Group experimental subjects is compared using the eyesight before embodiment.
This product in actual use, by the way that the propolis and vitamin B of corresponding amount are added into finished product, and stirs evenly
After carry out using.The application method of this product is every 3 days with 1 time, and each dosage is 1.5mL, 30 days as a treatment course, using general
Product in embodiment is applied at the eye circumference of experimental subjects, and with positions such as stone needle massage eye circumference channels and collaterals or acupuncture points, utilization is transdermal
Absorption plays therapeutic effect to experimental subjects.This experiment be with a treatment course after observe and obtain to draw a conclusion,
It is as shown in table 1:
1 child of tender age of table (3-7 years old) amblyopia treatment uncorrected visual acuity table
Note: L in table: the left vision value of experimental subjects is represented；R: the right vision value of experimental subjects is represented.
By table 1 as the result is shown it is found that in the embodiment of the medicament of the treatment amblyopia provided by the invention, embodiment 9
Best with therapeutic effect of the embodiment 10 to experimental subjects, remaining each embodiment all has apparent effect for experimental subjects
Fruit.Meanwhile from the data in table it can be found that experimental subjects 1-4 is after having used embodiment 1-4, uncorrected visual acuity data
It is whole that eyesight value rapid growth state is presented；For experimental subjects 5-8 after having used embodiment 5-8, uncorrected visual acuity data are whole
Eyesight value is presented and slowly increases state；After having used embodiment 9,10, uncorrected visual acuity data are integrally in experimental subjects 9,10
Existing eyesight value sustainable growth state.
30 eyes are randomly selected with amblyopia, the teenager that physical condition is good, the age is between 8-12 (comprising 12) years old
As experimental subjects, above-mentioned 30 juvenile patients are divided into 3 groups, and every group 10, wherein the amblyopia situation distribution of every group of juvenile patients
Uniformly.The Chinese materia medica preparation for the treatment amblyopia being prepared in the various embodiments described above respectively tests each group experimental subjects
And it monitors.First group of 10 experimental subjects are numbered: 1-10, the experimental subjects after each number are opposite using this product
The embodiment answered, remaining 2 groups of fortune carry out the distribution and use of embodiment, the overall effect of 3 groups of observation in the same way.Every group
Experimental subjects is compared using the eyesight before embodiment.
This product in actual use, by the way that the propolis and vitamin B of corresponding amount are added into finished product, and stirs evenly
After carry out using.The application method of this product is every 3 days with 1 time, and each dosage is 1.5mL, 30 days as a treatment course, using general
Product in embodiment is applied at the eye circumference of experimental subjects, and with positions such as stone needle massage eye circumference channels and collaterals or acupuncture points, utilization is transdermal
Absorption plays therapeutic effect to experimental subjects.This experiment be with a treatment course after observe and obtain to draw a conclusion,
It is as shown in table 2:
Juvenile (8-12 years old) amblyopia treatment uncorrected visual acuity table of table 2
Note: L in table: the left vision value of experimental subjects is represented；R: the right vision value of experimental subjects is represented.
By table 2 as the result is shown it is found that in the embodiment of the medicament of the treatment amblyopia provided by the invention, embodiment 9
Best with therapeutic effect of the embodiment 10 to experimental subjects, remaining each embodiment all has apparent effect for experimental subjects
Fruit.Meanwhile from the data in table it can be found that experimental subjects 1-4 is after having used embodiment 1-4, uncorrected visual acuity data
It is whole that eyesight value rapid growth state is presented；For experimental subjects 5-8 after having used embodiment 5-8, uncorrected visual acuity data are whole
Eyesight value is presented and slowly increases state；After having used embodiment 9,10, uncorrected visual acuity data are integrally in experimental subjects 9,10
Existing eyesight value sustainable growth state.
When the present invention prepares above-described embodiment in the specific implementation process, addition propolis and vitamin B and this hair have been selected
The verifying prepared and tested between bright finished product.Finished product is used to using propolis and vitamin B in the present embodiment to mention
For lubricant, to reduce frictional force when contacting in use with periocualr skin.About propolis and vitamin B and this hair
Bright finished product, which carries out dosage when fusion is prepared, to carry out phase according to the finished product use state finally presented in specific implementation process
Corresponding setting.
It is for playing moisten effect, while effectively rush to eye part skin by the way that propolis and vitamin B etc. are added in finished product
Enter human body into the transdermal absorption of medicinal ingredient in finished product medicinal extract.It is to be used for regard to the above-mentioned propolis used and vitamin B
It organically blends with finished product, which further includes water, butanediol, glycerol, carbomer, hyaluronic acid, polyglutamic acid, sweet
Oily caprylate, decoyl hydroximic acid, 1,2- pentanediol, parahydroxyacet-ophenone.By the configuration proportion between above-mentioned organic matter and finished product
Corresponding setting can be carried out according to specific product, and above-mentioned organic matter is not limited in the object of the present embodiment and above-mentioned offer
Matter, all good between finished product of the invention to merge, the product of generation can reach belonging to originally for treatment amblyopia
The protection scope of invention.
The invention discloses a kind of Chinese materia medica preparations and preparation method thereof for treating amblyopia.The Chinese materia medica preparation passes through selection
Prepared by resourceful Chinese medicine, and be clinically applied.Medicinal material in the Chinese materia medica preparation complements each other, compatibility obtains
When, effectively strengthen between each medicinal material it is mutual fusion and effect, thus reach dredging eye channels and collaterals, transfer eye qi and blood, mend
Fill nutrition needed for eye, alleviate eye strain effectively facilitated development of vision system at the same time, enhance the spirit of visual cell
Sensitivity activates and has repaired the activity of eye damaged cell and degenerated cell, improves the microcirculation of eye, has been obviously improved view
Power has high curative effect to amblyopia, achievees the purpose that treat amblyopia from the root.The preparation method operating process letter of the medicament
It is single, of less demanding to operator and low in cost.Without any side effects, the individual suitable for each age group of the invention.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that the present invention is not limited to
Optional embodiment is stated, anyone can obtain other various forms of products under the inspiration of the present invention.Above-mentioned specific reality
The mode of applying should not be understood the limitation of pairs of protection scope of the present invention, those skilled in the art should understand that, it is not carrying on the back
In the case where from the spirit and scope of the present invention, it is possible to modify the technical solutions described in the foregoing embodiments, or
Equivalent substitution of some or all of the technical features, these are modified or replaceed at the same time, can't make corresponding
The essence of technical solution depart from the scope of the technical solutions of the embodiments of the present invention；Protection scope of the present invention should be wanted with right
It asks subject to being defined in book, and specification can be used for interpreting the claims.
Claims (10)
1. a kind of for treating the Chinese materia medica preparation of amblyopia, which is characterized in that the Chinese materia medica preparation is mainly by following mass fraction
Raw material is prepared:
10-100 parts of pot marigold, 10-90 parts of ginkgo leaf, 10-80 parts of Radix Malvae sylvestris flower, 3-50 parts of hamamelis and ginseng 10-98
Part.
2. according to claim 1 a kind of for treating the Chinese materia medica preparation of amblyopia, which is characterized in that the Chinese materia medica preparation master
It to be prepared by the raw material of following mass fraction:
30-50 parts of pot marigold, 28-40 parts of ginkgo leaf, 15-35 parts of Radix Malvae sylvestris flower, 8-28 parts of hamamelis and ginseng 45-60
Part.
3. according to claim 2 a kind of for treating the Chinese materia medica preparation of amblyopia, which is characterized in that the Chinese materia medica preparation master
It to be prepared by the raw material of following mass fraction:
35 parts of pot marigold, 30 parts of ginkgo leaf, Radix Malvae sylvestris spend 20 parts, 10 parts of hamamelis and 50 parts of ginseng.
4. according to claim 1 to 3 a kind of for treating the preparation method of the Chinese materia medica preparation of amblyopia, feature exists
In the preparation method includes the following steps:
(1) it drying and dehydrating: is mixed after weighing pot marigold, ginkgo leaf, Radix Malvae sylvestris flower, hamamelis and ginseng according to corresponding proportion
It is dried and dehydrated；
(2) it crushes, impregnate and heat: being mixed after the raw material after drying and dehydrating in step (1) are crushed, to mixing former material
Solvent soaking is added in material and heats, obtains stoste extract；
(3) extracting solutions；Organic solvent is added into stoste extract obtained in step (2), is added again after stirring
Heat obtains an extracting solution；
(4) secondary raffinate: desiccant is added into an extracting solution obtained in step (3), obtains secondary raffinate；
(5) extracting solution three times: solvent is added into secondary raffinate obtained in step (4), obtains extracting solution three times；
(6) it rinses: by extracting solution crystallizes three times obtained in step (5), rinsing crystal, obtain head product；
(7) finished product is made: after head product obtained in step (6) is dried finished product is made.
5. according to claim 4 a kind of for treating the preparation method of the Chinese materia medica preparation of amblyopia, which is characterized in that described
It includes any one in water, ethyl alcohol or n-hexane that solvent is added in step (2).
6. according to claim 4 a kind of for treating the preparation method of the Chinese materia medica preparation of amblyopia, which is characterized in that described
Heating temperature is 20-80 degrees Celsius in step (2)；
Preferably, the heating temperature is 30-65 degrees Celsius；
It is further preferred that the heating temperature is 60 degrees Celsius.
7. according to claim 4 a kind of for treating the preparation method of the Chinese materia medica preparation of amblyopia, which is characterized in that described
It includes any one in Propylene Glycol or ethyl alcohol that organic solvent is added in step (3).
8. according to claim 4 a kind of for treating the preparation method of the Chinese materia medica preparation of amblyopia, which is characterized in that described
The desiccant being added in step (4) includes any one in potassium hydroxide, calcium hydroxide, quick lime or soda lime.
9. according to claim 4 a kind of for treating the preparation method of the Chinese materia medica preparation of amblyopia, which is characterized in that described
The solvent being added in step (5) includes water, and amount of water and weighed medicinal material total quality ratio are 25-65:3-8；
Preferably, the amount of water and weighed medicinal material total quality ratio are 30-40:5-6.5.
10. according to claim 4 a kind of for treating the preparation method of the Chinese materia medica preparation of amblyopia, which is characterized in that institute
Stating step (7) drying temperature is 10-40 degrees Celsius；Drying time is 12-72 hours；
Preferably, the drying temperature is 20-30 degrees Celsius；Drying time is 24-55 hours；
It is further preferred that the drying temperature is 25 degrees Celsius；Drying time is 48 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910498009.2A CN110051716A (en) | 2019-06-10 | 2019-06-10 | A kind of Chinese materia medica preparation and preparation method thereof for treating amblyopia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910498009.2A CN110051716A (en) | 2019-06-10 | 2019-06-10 | A kind of Chinese materia medica preparation and preparation method thereof for treating amblyopia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110051716A true CN110051716A (en) | 2019-07-26 |
Family
ID=67325708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910498009.2A Pending CN110051716A (en) | 2019-06-10 | 2019-06-10 | A kind of Chinese materia medica preparation and preparation method thereof for treating amblyopia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110051716A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110025712A (en) * | 2019-05-30 | 2019-07-19 | 北京中创视界科技有限公司 | A kind of Chinese materia medica preparation and preparation method thereof for treating myopia |
| CN112451622A (en) * | 2020-11-27 | 2021-03-09 | 宋津锋 | A preparation for treating myopia, amblyopia and astigmatism, and its preparation method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266445A (en) * | 2011-07-22 | 2011-12-07 | 佘志坚 | Eye protection Chinese medicinal composition with health care and treatment effects |
| US20160067297A1 (en) * | 2013-04-08 | 2016-03-10 | Jianxue Wei | Eye-refreshing agent to eliminate and alleviate eye fatigue and discomfort |
-
2019
- 2019-06-10 CN CN201910498009.2A patent/CN110051716A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266445A (en) * | 2011-07-22 | 2011-12-07 | 佘志坚 | Eye protection Chinese medicinal composition with health care and treatment effects |
| US20160067297A1 (en) * | 2013-04-08 | 2016-03-10 | Jianxue Wei | Eye-refreshing agent to eliminate and alleviate eye fatigue and discomfort |
Non-Patent Citations (1)
| Title |
|---|
| 邢占芬 等: "金盏花HPLC特征指纹图谱研究", 《中药材》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110025712A (en) * | 2019-05-30 | 2019-07-19 | 北京中创视界科技有限公司 | A kind of Chinese materia medica preparation and preparation method thereof for treating myopia |
| CN112451622A (en) * | 2020-11-27 | 2021-03-09 | 宋津锋 | A preparation for treating myopia, amblyopia and astigmatism, and its preparation method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101648004B (en) | Medicinal composition for treating eye diseases and application thereof | |
| CN105343739A (en) | Ointment for treating myopia and preparation method of ointment | |
| CN102178784B (en) | Combination therapy used for treating visual disturbances and damages and relieving asthenopia | |
| CN110170000A (en) | A kind of Chinese medicine composition and preparation method thereof for helping to improve eyesight | |
| CN105853877B (en) | Weight-losing pharmaceutical composition, preparation containing same and preparation method thereof | |
| CN102188604A (en) | Medicament for treating myopia and presbyopia | |
| CN110051716A (en) | A kind of Chinese materia medica preparation and preparation method thereof for treating amblyopia | |
| CN102166203B (en) | Eye pad for alleviating eye fatigue and preparation method thereof | |
| CN107412489A (en) | A kind of eye conditioning liquid, eye patch and conditioning liquid, the preparation method of eye patch | |
| CN103446365B (en) | Ointment for treating myopia and preparation method thereof | |
| CN101829043B (en) | Traditional Chinese medicine facial mask for improving sleep quality and preparation method thereof | |
| CN104706820A (en) | Chinese herbal medicine containing eye-protecting tablet | |
| CN106420513A (en) | Traditional Chinese medicine extraction composition with effects of whitening skin and dispelling speckle and preparation method and application of traditional Chinese medicine extraction composition | |
| CN102949523A (en) | Medicinal composition used for relieving visual fatigue and preparation method of capsules thereof | |
| CN106377635A (en) | Traditional Chinese medicine formula for reducing white hair and gray hair | |
| CN105878147A (en) | Pure natural pearl powder neck mask | |
| CN109432393A (en) | A kind of eye-care is spraying and preparation method thereof | |
| CN108888682A (en) | A kind of improving eyesight eyeshield composition | |
| CN104288303A (en) | Traditional Chinese medicine for treating cardiovascular and cerebrovascular diseases | |
| CN101708323B (en) | Trichogenous cream | |
| CN107349387A (en) | A kind of Traditional Chinese medicine foot bath bag of nourishing yin and nourishing blood and preparation method thereof | |
| CN107881075A (en) | A kind of antilipemic healthy wine | |
| CN106177130A (en) | A kind of manufacture method of the Chinese medicine eye ointment treating myopia | |
| CN103566067A (en) | Composition for treating eye diseases and its application | |
| CN102293730B (en) | Application of refined deer oil in preparation of beauty breast cosmetics |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190726 |