CN109998625A - A kind of tissue folder - Google Patents
A kind of tissue folder Download PDFInfo
- Publication number
- CN109998625A CN109998625A CN201910241108.2A CN201910241108A CN109998625A CN 109998625 A CN109998625 A CN 109998625A CN 201910241108 A CN201910241108 A CN 201910241108A CN 109998625 A CN109998625 A CN 109998625A
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- China
- Prior art keywords
- clamp
- foam material
- elastic foam
- tissue
- tissue folder
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/122—Clamps or clips, e.g. for the umbilical cord
- A61B17/1227—Spring clips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00526—Methods of manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00862—Material properties elastic or resilient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00867—Material properties shape memory effect
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention relates to a kind of tissue folder, including upper clamp and lower clamp, the head of the upper clamp and lower clamp is equipped with mutually matched buckle structure, and the nip side of the upper clamp and/or lower clamp is equipped with elastic foam material.Tissue folder solves conventional organization folder and closes hidden danger caused by rear forming gap is fixed as pressing from both sides, and thin, cell can be fastened and avoid de- folder oozing of blood, can also play buffer protection function for blocked up tissue.
Description
Technical field
The present invention relates to medical instruments, and in particular to a kind of tissue folder.
Background technique
The main application of tissue folder is the closing to intracorporeal site, is mainly closed or is ligatured by linear slit originally, but
It is that linear slit closes or to ligature its defect be that operating time is long, operating difficulty is big, it is desirable that doctor has a very strong suture knot tying techniques, and ten thousand
One knot bundle not will cause loose ends or off-line phenomenon tightly, cause patient's bleeding, and wound healing is slow.
The common type of tissue folder has metal clip and conventional organization folder.Metal clip is usually U-shaped, and using simple, curative effect is true
It cuts, is clinically widely used.But the disadvantage is that without self-locking at its closure after U-shaped folder deformation, by the bullet of folder tissue
Under the action of property restoring force, easily there is slip phenomenon.For dynamics when clamp by doctor's manual control, clamp tension can press quick-fried or cutting group
It knits and causes operative failure, clamp pine excessively is then easily de- to be pressed from both sides.And metal material nonabsorable, postoperative is internal foreign matter.
The synthetic material of conventional organization folder includes absorbable and nonabsorable high molecular polymer.It common are the U.S.
Hemolock ligation clip and the ABSOLOK absorbable biological folder of Johson & Johnson of Weck company etc..In addition, 1954781 A of CN is public
Open a kind of absorbable tissue clamp, manufactured with the biodegradation material that can be chronically implanted in human body, there are two cooperate and to
The curved arched arm of same direction, on the head of arched arm with a pair of self-locking device that can be worked in coordination, two arched arm structures
Forming V-shape structure.The ligation clip of this type has used shackle designs, safer.
But existing tissue folder is preform, the clearance constant after folder closes between tissue folder two-arm, so for thin group
A possibility that knitting for such as tiny vein, taking off folder is bigger, and for blocked up tissue, then tissue is cut when being closed in the presence of folder
The risk cut.
Summary of the invention
In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to provide a kind of tissue folder, solve conventional organization folder by
Closing rear forming gap locking in folder loosely leads to the insecurity of oozing of blood at closure, and can avoid cutting well, press quick-fried tissue
Cause operative failure.
Technical solution provided by the present invention are as follows:
The head of a kind of tissue folder, including upper clamp and lower clamp, the upper clamp and lower clamp is equipped with mutually matched
The nip side of buckle structure, the upper clamp and/or lower clamp is equipped with elastic foam material.
It is equipped with elastic foam material in the nip side of upper clamp and/or lower clamp in the present invention, due to elastic foam material
With certain porosity, there is buffer function, and biggish frictional force can be provided, it is ensured that quick-fried group will not be pressed from both sides when application tissue folder
It knits, but can fasten well.
Elastic foam material can be provided only on the nip side of upper clamp or the nip side of lower clamp in the present invention, preferably
The nip side of upper clamp and lower clamp is set.
The nip side of heretofore described upper clamp and/or lower clamp is equipped with groove, and the elastic foam material is filled in
In groove.Preferably, the nip side of the upper clamp and lower clamp be all provided with it is fluted.Elastic foam material is according to the spy of groove
Determine size and shape to be processed.
Heretofore described upper clamp and lower clamp and elastic foam material can be made of biodegradation material.
Preferably, the biodegradation material is selected from one or more of polylactic acid, polycaprolactone, polyethylene glycol.
The shape of folder is organized in the present invention can be made of biodegradation material, be cut by laser using existing structure
It cuts, mold manufacture, the modes such as three-dimensional manufacture are moulded.
Heretofore described elastic foam material can be by systems such as direct synthesis technique, template, foaming, three-dimensional autofrettages
It is standby.
Preferably, the elastic foam material is prepared using foaming: by diphenylmethylene diisocyanate, poly- second
Glycol (Mn=200), pentaerythrite, foaming agent and catalyst are uniformly mixed, and stand foaming is formed poly- at 80~90 DEG C
Urethane foam.
Preferably, the elastic foam material is prepared using ice template method: PEGDA is dissolved in deionization at room temperature
10~20wt% solution is made into water.After the aqueous solution is pre-chilled to 0 DEG C, APS and TEMED are sequentially added, after mixing
It has been placed in glass plywood container.It uses cold ethanol or liquid chlorine to freeze precursor liquid as cold source to freeze completely to precursor liquid
Afterwards, it is transferred into -15 DEG C of refrigerator, polymerization reaction carries out 24 hours at this temperature, forms the three-dimensional network of gel
Structure.It is drawn off after melting at room temperature, impregnates 48 hours with a large amount of deionized water to remove unreacting substance.
Preferably, the elastic foam material is manufactured using three-dimensional method: by acryloyl morpholine, two propylene of polyethylene glycol
Acid esters and dodecylacrylate mixing, are added bis- (2,4, the 6- trimethylbenzoyl) phosphine oxides of photoinitiator phenyl and dye
Material obtains three-dimensional target foam by successively printing in 3D printer.
Preferably, the elastic foam material is prepared using emulsion method: the cream formed in water by acrylic resin
Frozen dried is carried out again after liquid frost, that is, can be grouped to as elastic foam material.
Preferably, the elastic foam material is using epoxy resin/microballoon mixed system preparation: by curing agent, (it adds
Enter 1~3% that amount is system gross mass) and the tiny balloon of certain mass point rate be mixed into resin slurry, pour into mold 20~
40 DEG C of solidifications 12~for 24 hours, then solidify 2~4h after 50~80 DEG C, elastic foam material can be obtained.
Heretofore described elastic foam material is shape-memory polymer.
Preferably, the shape-memory polymer includes: light-induced shape-memory polymer or thermal shape memory polymerization
Object.
Preferably, the elastic foam material is thermal shape memory polymer, deformed before being filled into groove
Processing.
Preferably, the deformation process refers to: thermal shape memory polymer is compressed more than transition temperature,
Fix the temporary shapes.
Preferably, the thermal shape memory polymer is in polyester resin, polyurethane resin, acrylate
One or more.
Preferably, the nip side of the upper clamp and lower clamp is equipped with elastic foam material, the upper clamp is under
Mutually matched clamp structure is equipped between elastic foam material on clamp.Further preferably, the elasticity on the upper clamp
Foamed material is equipped with groove, and the elastic foam material on the lower clamp is equipped with the protrusion cooperated with groove, the clamp structure
It is made of groove and protrusion.
Compared with the existing technology, the beneficial effects of the present invention are embodied in:
The present invention increases tissue folder with target and ligatures tissue by filling elastic foam material in the groove of tissue folder
Contact area, and provide bigger frictional force, solve conventional organization folder as folder close rear forming gap it is fixed caused by it is hidden
Suffer from, thin, cell (such as vein) can be fastened and avoid de- folder oozing of blood, buffer protection work can be also played for blocked up tissue
With.
Detailed description of the invention
Fig. 1 is the structural schematic diagram that the tissue folder of elastic foam material is not filled by embodiment；
Fig. 2 is that the structural schematic diagram of the tissue folder of elastic foam material is filled in embodiment；
Fig. 3 is that the tissue clamping structure schematic diagram of the elastic foam material of fit structure is filled in embodiment.
Specific embodiment
Below with reference to specific embodiment, present invention will be explained in further detail.
As a kind of specific embodiment of tissue folder, as described in Fig. 1 and 2, tissue folder is made of upper clamp 1 and lower clamp 2.
Upper clamp 1 is connected with 2 one end of lower clamp, and the two can be along connecting pin relative rotation.The other end is head, is equipped with and cooperates
Buckle structure 5.The nip side of upper clamp 1 and lower clamp 2 is equipped with groove 4, is filled with elastic foam material 6 in groove 4.
As another specific embodiment of tissue folder, groove 4 can also only be set in the side of upper clamp 1 or lower clamp 2
It sets.
As another specific embodiment of tissue folder, groove 4 may be designed in can mutually matched pattern.
As another specific embodiment of tissue folder, such as Fig. 3, elastic foam 6 may be designed in can be mutually matched
Clamp structure, the elastic foam material 6 on upper clamp 1 are equipped with groove, and the elastic foam material 6 on lower clamp 2 is equipped with and groove
The protrusion of cooperation, clamp structure are made of groove and protrusion.
Embodiment 1: tissue folder clamp is prepared
Tissue folder clamp can be manufactured by laser cutting method: weigh 1mmol methyl methacrylate, 0.2mmol gathers in oneself
Ester diacrylate (Mn=10000) and dibenzoyl peroxide amine (its additional amount is the 2% of system gross mass), are heating and curing
At with certain thickness plate, target clamp shape is cut into using laser cutting machine.
Embodiment 2: tissue folder clamp is prepared
Tissue folder clamp can be fabricated by mold: being obtained metal die by mechanical means, weighed 1mmol bisphenol-A two
Synthesis of Oligo Ethylene Glycol and 1mmol polyetheramine inject mold after mixing and are heated to 100 DEG C of curing moldings, can be obtained after demoulding
Target clamp.
Embodiment 3: tissue folder clamp is prepared
Tissue folder clamp can be made by three-dimensional manufacturing method: weigh 1mmol isobornyl acrylate, 0.6mmol 1,6 oneself
Bis- (2,4, the 6- trimethylbenzoyls of photoinitiator phenyl are added in omega-diol diacrylate and 1mmol dodecylacrylate
Base) phosphine oxide (its additional amount be system gross mass 2%) and dyestuff (its additional amount be system gross mass 2%), it is beaten in 3D
Three-dimensional target clamp is obtained by successively printing in print machine.
Embodiment 4: tissue folder clamp is prepared
Tissue folder clamp can be manufactured by fused raw material mating mold or extruded type printer: for example by polylactic acid granule heating
Mold or extruded type printer are injected after softening, target clamp can be obtained in cooling after demoulding or molding.Wherein polylactic acid is made a living
Biodegradable material.
Embodiment 5: tissue folder clamp is prepared
Tissue folder clamp can be by 1mmol polyethylene glycol, 1.2mmol1,4- butanediol, 0.1mmol triethanolamine, 2.2mmol
Isophorone diisocyanate and 0.01mmol catalyst are uniformly mixed, and curing molding is reacted at 80 DEG C, after demoulding i.e.
Target clamp can be obtained.
Embodiment 6: elastic foam material is prepared
Elastic foam material can be prepared by foaming: 0.7mmol diphenylmethylene diisocyanate, 0.5mmol are gathered
Ethylene glycol (Mn=200), 0.1mmol pentaerythrite, 0.1mmol foaming agent and 0.05mmol catalyst are uniformly mixed,
Stand foaming forms polyurethane foam at 85 DEG C.
Obtained elastic foam material is cut into specific dimensions, shape, is pasted on the reserved groove of tissue folder.
The foam as used in the present embodiment has thermal shape memory effect, and transition temperature and body temperature are close,
After the deformation process for first passing through compression in advance, in body temperature fluid environment under the collective effect of hydrogen bond and money transition temperature, without outer
Source heating can slowly be returned to original-shape, safely and reliably ligature target blood or tissue.
The shape memory foam compressed in advance in clamp groove can slowly expand clamping delicate tissue under body temperature environment,
Such as bean curd, it is not easy that tissue is caused to cut, has more advantage relative to filling regular-type foam.
Embodiment 7: elastic foam material is prepared
Elastic foam material can be prepared by ice template method: being weighed the PEGDA of 0.45g, be dissolved in 3mL deionization at room temperature
15wt% solution is made into water.After the aqueous solution is pre-chilled to 0 DEG C, sequentially add APS (4wt% aqueous solution, 100 μ L) and
TEMED (10 μ L) is uniformly mixed and has been placed in glass plywood container.Use cold ethanol or liquid chlorine as cold source to precursor liquid into
Row frost is transferred into -15 DEG C of refrigerator, it is small that polymerization reaction carries out 24 at this temperature after precursor liquid freezes completely
When, form the three-dimensional net structure of gel.Be drawn off after melting at room temperature, with a large amount of deionized water impregnate 48 hours with
Remove unreacting substance.
Obtained elastic foam material is cut into specific dimensions, shape, is pasted on the reserved groove of tissue folder.
The foam as used in the present embodiment has thermal shape memory effect, can first pass through in advance at the deformation of compression
Reason, can gradually be returned to original-shape under the conditions ofs heating, illumination (photothermal conversion) etc., safely and reliably ligature target blood
Pipe or tissue.
Slowly expansion clamps delicate tissue, such as beans to the shape memory foam compressed in advance in clamp groove after heating
Corruption is not easy to cause to cut to tissue, has more advantage relative to filling regular-type foam.
Embodiment 8: elastic foam material is prepared
Elastic foam material can be obtained by three-dimensional manufacturing method: weigh 1mmol acryloyl morpholine, 0.6mmol polyethylene glycol
Bis- (2,4, the 6- trimethylbenzoyl) oxygen of photoinitiator phenyl are added in diacrylate and 1mmol dodecylacrylate
Change phosphine (its additional amount be system gross mass 2%) and dyestuff (its additional amount be system gross mass 2%), in 3D printer
Three-dimensional target foam is obtained by successively printing.Obtained elastic foam material is cut into specific dimensions, shape, is pasted
On the reserved groove of tissue folder.
Embodiment 9: elastic foam material is prepared
Elastic foam material can be prepared by emulsion method: be carried out again after the lotion frost formed in water by acrylic resin
Frozen dried can be grouped to as elastic foam material.Obtained elastic foam material is cut into specific dimensions, shape,
It is pasted on the reserved groove of tissue folder.
Embodiment 10: elastic foam material is prepared
Elastic foam can be prepared by epoxy resin/microballoon mixed system, and by curing agent, (its additional amount is system gross mass
2%) and the tiny balloon of certain mass point rate be mixed into resin slurry, pour into mold 20~40 DEG C solidify 12~for 24 hours, then exist
Solidify 2~4h after 50~80 DEG C, elastic foam material can be obtained.In addition, by gradually toppling over uniform pre-polymerization in a mold
Liquid acts on forming functionally gradient epoxy synthetic foam using the flowing and viscous force of microballoon.Adjust the methods of the density contrast of microballoon
Available gradient epoxy synthetic foam, brings more excellent cushion performance.Obtained elastic foam material is cut into
Specific dimensions, shape are pasted on the reserved groove of tissue folder.
Claims (10)
1. the head of a kind of tissue folder, including upper clamp and lower clamp, the upper clamp and lower clamp is equipped with mutually matched card
Buckle structure, which is characterized in that the nip side of the upper clamp and/or lower clamp is equipped with elastic foam material.
2. tissue folder according to claim 1, which is characterized in that the nip side of the upper clamp and/or lower clamp is equipped with
Groove, the elastic foam material are filled in groove.
3. tissue folder according to claim 1, which is characterized in that the upper clamp and lower clamp and elastic foam material can
It is made of biodegradation material.
4. tissue folder according to claim 3, which is characterized in that the biodegradation material is selected from polylactic acid, gathers in oneself
One or more of ester, polyethylene glycol.
5. tissue folder according to claim 1, which is characterized in that the elastic foam material is shape-memory polymer.
6. tissue folder according to claim 5, which is characterized in that the shape-memory polymer includes: thermotropic shape note
Recall polymer or light-induced shape-memory polymer.
7. tissue folder according to claim 2, which is characterized in that the elastic foam material is thermal shape memory polymerization
Object carries out deformation process before being filled into groove.
8. tissue folder according to claim 7, which is characterized in that the deformation process refers to: thermal shape memory is gathered
It closes object to be compressed more than transition temperature, fixes the temporary shapes.
9. tissue folder according to claim 7, which is characterized in that the thermal shape memory polymer is selected from polyester tree
One or more of rouge, polyurethane resin, acrylate.
10. tissue folder according to claim 1, which is characterized in that the nip side of the upper clamp and lower clamp is equipped with
Elastic foam material is equipped with mutually matched clamp structure between the elastic foam material on the upper clamp and lower clamp.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910241108.2A CN109998625A (en) | 2019-03-28 | 2019-03-28 | A kind of tissue folder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910241108.2A CN109998625A (en) | 2019-03-28 | 2019-03-28 | A kind of tissue folder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109998625A true CN109998625A (en) | 2019-07-12 |
Family
ID=67168548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910241108.2A Pending CN109998625A (en) | 2019-03-28 | 2019-03-28 | A kind of tissue folder |
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| CN (1) | CN109998625A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111513772A (en) * | 2020-03-30 | 2020-08-11 | 上海市浦东新区公利医院(第二军医大学附属公利医院) | Puncture sample extraction element |
| CN113288320A (en) * | 2021-07-07 | 2021-08-24 | 哈尔滨工业大学 | Ligation clip with shape memory function |
| CN113349869A (en) * | 2021-07-22 | 2021-09-07 | 苏州美东汇成精密部件有限公司 | Novel disposable hemostatic clamp |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111513772A (en) * | 2020-03-30 | 2020-08-11 | 上海市浦东新区公利医院(第二军医大学附属公利医院) | Puncture sample extraction element |
| CN111513772B (en) * | 2020-03-30 | 2023-05-30 | 上海市浦东新区公利医院(第二军医大学附属公利医院) | Puncture specimen extraction device |
| CN113288320A (en) * | 2021-07-07 | 2021-08-24 | 哈尔滨工业大学 | Ligation clip with shape memory function |
| CN113349869A (en) * | 2021-07-22 | 2021-09-07 | 苏州美东汇成精密部件有限公司 | Novel disposable hemostatic clamp |
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