CN109998602B - Special sampler of alimentary canal tumour biopsy tissue - Google Patents

Special sampler of alimentary canal tumour biopsy tissue Download PDF

Info

Publication number
CN109998602B
CN109998602B CN201910327971.XA CN201910327971A CN109998602B CN 109998602 B CN109998602 B CN 109998602B CN 201910327971 A CN201910327971 A CN 201910327971A CN 109998602 B CN109998602 B CN 109998602B
Authority
CN
China
Prior art keywords
sampling
box
sample
sampling box
catheter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201910327971.XA
Other languages
Chinese (zh)
Other versions
CN109998602A (en
Inventor
于志红
郑福增
郭志忠
刘培民
周世繁
周超锋
张瑜
王玉萍
胡玉娜
郭军辉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henan Hospital Traditional Chinese Medicine Second Affiliated Hospital of Henan University of Traditional Chinese Medicine TCM
Original Assignee
Henan Hospital Traditional Chinese Medicine Second Affiliated Hospital of Henan University of Traditional Chinese Medicine TCM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henan Hospital Traditional Chinese Medicine Second Affiliated Hospital of Henan University of Traditional Chinese Medicine TCM filed Critical Henan Hospital Traditional Chinese Medicine Second Affiliated Hospital of Henan University of Traditional Chinese Medicine TCM
Priority to CN201910327971.XA priority Critical patent/CN109998602B/en
Publication of CN109998602A publication Critical patent/CN109998602A/en
Application granted granted Critical
Publication of CN109998602B publication Critical patent/CN109998602B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B10/0233Pointed or sharp biopsy instruments
    • A61B10/0266Pointed or sharp biopsy instruments means for severing sample
    • A61B10/0275Pointed or sharp biopsy instruments means for severing sample with sample notch, e.g. on the side of inner stylet
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B10/04Endoscopic instruments

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Endoscopes (AREA)

Abstract

The invention relates to the technical field of medical treatment, in particular to a special sampler for digestive tract tumor biopsy tissues, which comprises a catheter, a sampling box, a sampling mechanism and a pair of clamping knives, wherein the sampling box is arranged at the head part of the catheter through two rotating shafts, the cylindrical surface of the head part of the catheter is provided with a sampling port, the head part of the sampling box is attached to the sampling port on the catheter, the two rotating shafts penetrate through the sampling box and are inserted at two ends in the length direction of the sampling port, the pair of clamping knives are symmetrically arranged at the head part of the sampling box, the tail part of each clamping knife can be rotatably sleeved on the rotating shaft at the corresponding position, and the sampling mechanism is arranged in the sampling box and the catheter. The invention has simple structure and convenient operation, all the structures are positioned in the catheter or attached to the outer wall of the catheter, the digestive tract can not be damaged, and the sampling tissue is cut and clamped by the clamping knife during sampling, so that the sampling tissue is not easy to fall and lose.

Description

Special sampler of alimentary canal tumour biopsy tissue
Technical Field
The invention relates to the technical field of medical treatment, in particular to a sampler special for digestive tract tumor biopsy tissues.
Background
The digestive tract diseases are common diseases affecting the body health of modern people, but because the digestion is in the human body, diagnosis and treatment of related diseases need corresponding observation and inspection, visual detection has very important effect on prevention and diagnosis and treatment of the digestive tract diseases, the shape of the digestive tract of the human body belongs to a long and thin pipeline and is distributed among various organs of the trunk of the human body, the structure of the digestive tract is irregular, the total length of the digestive tract in the human body reaches 8m, and the detection and sampling of the digestive tract diseases in clinic are greatly challenged. Clinically, in order to determine the nature of the alimentary canal tumor, biopsy sampling must be carried out, the traditional method is to swallow an air bag by a patient, the alimentary canal is expanded, then a doctor holds an instrument by hand to carry out biopsy sampling, so the operation is troublesome, the doctor is more strenuous, the patient is painful, the existing alimentary canal tumor biopsy sampler adopts a scraping blade arranged on a soft supporting arm, the patient does not need to swallow the air bag, the biopsy sampling is carried out by directly adopting the scraping blade, the sampler with the structure does not need to swallow the air bag, but the protruded scraping blade can cause harm to the oral cavity and the alimentary canal when being inserted into and pulled out from the alimentary canal, the use is very unsafe, meanwhile, the taken tissue sample is on the scraping blade, and the tissue sample is easy to fall off and can not be taken out when being pulled out.
Disclosure of Invention
The invention aims to provide a sampler special for digestive tract tumor biopsy tissues.
In order to achieve the purpose, the invention adopts the following technical scheme:
the utility model provides a special sampler of alimentary canal tumour biopsy tissue, which comprises a guide pipe, the sample box, sampling mechanism and a pair of double-layered sword, the sample box sets up at the pipe head through two pivots, the face of cylinder of pipe head is provided with the sample connection, the head of sample box and the sample connection laminating on the pipe, two pivots are passed the sample box and are inserted the both ends of establishing sample connection length direction, a pair of double-layered sword symmetry sets up the head at the sample box, every afterbody homoenergetic pivoted cover that presss from both sides the sword is established in the pivot that corresponds the position, sampling mechanism sets up in sample box and pipe.
As an optimal selection scheme of the special sampler of alimentary canal tumour biopsy tissue, sampling mechanism includes push pedal, push rod and a pair of ejector pin, and the push pedal sets up in the sample box through two extension springs, the both ends of two extension springs all respectively with the afterbody and the push pedal fixed connection of sample box, the top of push rod sets up perpendicularly in the push pedal and keeps away from one side of pressing from both sides the sword and pass the afterbody of sample box outwards to extend to the pipe center, a pair of ejector pin is perpendicular respectively and the push pedal is close to the fixed both ends that set up at push pedal length direction in one side of pressing from both sides the sword, two ejector pin tops are contradicted with two intermediate positions that press from both sides the sword and be located the sample box medial surface that correspond respectively.
As an optimal scheme of the sampler special for the alimentary canal tumor biopsy tissue, one side of each clamping knife, which is positioned at the inner side of the sampling box, is connected with the inner wall of the sampling box through an elastic pull ring, and the two ends of each elastic pull ring are respectively arranged in the sampling box through buckles and on each clamping knife, and each buckle is respectively arranged at the corresponding position of the sampling box and the clamping knife.
As a preferred scheme of a special sampler for digestive tract tumor biopsy tissues, the tail parts of the push rod and the sampling box are respectively provided with a thread buckle, the push rod and the thread buckles on the sampling box are connected through a pull rope, one end of the pull rope is tightly tied on the thread buckle on the push rod, and the other end of the pull rope passes through the thread buckle on the sampling box and extends out of the tail part of the catheter.
As a preferable scheme of the sampler special for the alimentary canal tumor biopsy tissue, a plurality of illuminating lamps and cameras are arranged at the top end of the head part of the conduit and in the circumferential direction of the conduit, and one camera is over against the sampling port.
The invention has the beneficial effects that: during the sample, stretch into the alimentary canal with the pipe, seek and observe the sample tissue through light and camera, make the sample process clear more accurate. When the sample position was confirmed at the pipe head, make the push rod move at the length direction of sampling the box through the pulling stay cord, and then promote push pedal and ejector pin motion, promote the push pedal through the push rod and slide in sampling the box for two extension springs are tensile, and the push pedal promotes two ejector pins and then promotes two double-layered swoves and rotate round the device, makes two double-layered swoves open certain angle. When the ejector pin promotes to press from both sides the sword, press from both sides the sword pulling elasticity pull ring, press from both sides to aim at the sample tissue between the sword and open certain angle, take a sample to the sample tissue, then loosen the stay cord and let two extension springs shrink and make the ejector pin not with the double-layered sword contact that corresponds, two elasticity pull rings shrink simultaneously and stimulate two clamp sword directions and rotate, take a sample to the sample tissue and withdraw to the sample box.
The invention has simple structure and convenient operation, all the structures are positioned in the catheter or attached to the outer wall of the catheter, the digestive tract can not be damaged, and the sampling tissue is cut and clamped by the clamping knife during sampling, so that the sampling tissue is not easy to fall and lose.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required to be used in the embodiments of the present invention will be briefly described below. It is obvious that the drawings described below are only some embodiments of the invention, and that for a person skilled in the art, other drawings can be derived from them without inventive effort.
Fig. 1 is a schematic perspective view of the present invention.
Fig. 2 is a front view of the present invention.
Fig. 3 is a top view of the present invention.
Fig. 4 is a schematic perspective view of the present invention.
Fig. 5 is a schematic view of the internal structure of the present invention.
Fig. 6 is a sectional view at B-B in fig. 3.
Fig. 7 is a partially enlarged view of a portion a in fig. 5.
In the figure:
catheter 1, sample box 2, sampling mechanism 3, press from both sides sword 4, sample connection 5, pivot 6, elasticity pull ring 7, latch closure 8, line is detained 9, stay cord 10, light 11, camera 12, push pedal 3a, push rod 3c, ejector pin 3b, extension spring 3 d.
Detailed Description
The technical scheme of the invention is further explained by the specific implementation mode in combination with the attached drawings.
Wherein the showings are for the purpose of illustration only and are shown by way of illustration only and not in actual form, and are not to be construed as limiting the present patent; to better illustrate the embodiments of the present invention, some parts of the drawings may be omitted, enlarged or reduced, and do not represent the size of an actual product; it will be understood by those skilled in the art that certain well-known structures in the drawings and descriptions thereof may be omitted.
The same or similar reference numerals in the drawings of the embodiments of the present invention correspond to the same or similar components; in the description of the present invention, it should be understood that if the terms "upper", "lower", "left", "right", "inner", "outer", etc. are used for indicating the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, it is only for convenience of description and simplification of description, but it is not indicated or implied that the referred device or element must have a specific orientation, be constructed in a specific orientation and be operated, and therefore, the terms describing the positional relationship in the drawings are only used for illustrative purposes and are not to be construed as limitations of the present patent, and the specific meanings of the terms may be understood by those skilled in the art according to specific situations.
In the description of the present invention, unless otherwise explicitly specified or limited, the term "connected" or the like, if appearing to indicate a connection relationship between the components, is to be understood broadly, for example, as being fixed or detachable or integral; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or may be connected through one or more other components or may be in an interactive relationship with one another. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
As shown in fig. 1-7 a special sampler of alimentary canal tumour biopsy tissue, including pipe 1, sample box 2, sampling mechanism 3 and a pair of double-layered sword 4, sample box 2 sets up at pipe 1 head through two pivot 6, the face of cylinder of pipe 1 head is provided with sample connection 5, sample box 2's head and the 5 laminating of sample connection on the pipe 1, two pivot 6 pass sample box 2 and insert the both ends of establishing at sample connection 5 length direction, a pair of double-layered sword 4 symmetry sets up the head at sample box 2, every afterbody that presss from both sides sword 4 all can the pivoted cover establish on the pivot 6 of corresponding position, sampling mechanism 3 sets up in sample box 2 and pipe 1.
Sampling mechanism 3 includes push pedal 3a, push rod 3c and a pair of ejector pin 3b, push pedal 3a sets up in sampling box 2 through two extension springs 3d, two extension springs 3 d's both ends all with sampling box 2's afterbody and push pedal 3a fixed connection respectively, push rod 3 c's top sets up perpendicularly in push pedal 3a keeps away from one side of pressing from both sides sword 4 and passes the afterbody of sampling box 2 and outwards extend to pipe 1 center, a pair of ejector pin 3b is perpendicular respectively and is close to the fixed both ends that set up in push pedal 3a length direction in one side of pressing from both sides sword 4 with push pedal 3a, two ejector pin 3b tops are contradicted with the intermediate position that two clamp sword 4 that correspond are located sampling box 2 medial surfaces respectively. Stretch into the alimentary canal with pipe 1 during the sample in, when the sample position was solved to pipe 1 head, slide in sampling box 2 through push rod 3c promotion push pedal 3a for two extension springs 3d are tensile, and push pedal 3a promotes two ejector pins 3b and then promotes two double-layered sword 4 and rotates round the device, makes two double-layered sword 4 open certain angle.
Two one side that presss from both sides sword 4 to be located sampling box 2 inboard respectively through an elasticity pull ring 7 with the interior wall connection of sampling box 2, every elasticity pull ring 7's both ends all set up respectively in sampling box 2 and on pressing from both sides sword 4 through latch closure 8 and every latch closure 8 sets up respectively on sampling box 2 and the corresponding position of pressing from both sides sword 4. When ejector pin 3b promoted to press from both sides sword 4, press from both sides sword 4 pulling elasticity pull ring 7, press from both sides to aim at the sample tissue between the sword 4 and open certain angle, take a sample to the sample tissue, then two extension springs 3d shrink make ejector pin 3b not with the clamp sword 4 contact that corresponds, two elasticity pull rings 7 shrink simultaneously and stimulate two clamp sword 4 directions and rotate, take a sample to the sample tissue and withdraw to sample box 2.
The tail parts of the push rod 3c and the sampling box 2 are provided with wire buckles 9, the push rod 3c and the wire buckles 9 on the sampling box 2 are connected through a pull rope 10, one end of the pull rope 10 is tightly tied to the wire buckle 9 on the push rod 3c, and the other end of the pull rope 10 penetrates through the wire buckle 9 on the sampling box 2 and extends out of the tail part of the guide pipe 1. The push rod 3c moves in the length direction of the sampling box 2 by pulling the pull rope 10, and then pushes the push plate 3a and the push rod 3b to move.
The top end of the head part of the conduit 1 and the circumferential direction thereof are provided with a plurality of illuminating lamps 11 and cameras 12, wherein one camera 12 is over against the sampling port 5. The sampling tissue is searched and observed through the illuminating lamp 11 and the camera 12, so that the sampling process is clearer and more accurate.
The working principle is as follows: during the sample, stretch into the alimentary canal with pipe 1, look for and observe the sample tissue through light 11 and camera 12, make the sample process clear more accurate. The push rod 3c moves in the length direction of the sampling box 2 by pulling the pull rope 10, and then pushes the push plate 3a and the push rod 3b to move. When the sampling position is solved at the head of the catheter 1, the push plate 3a is pushed by the push rod 3c to slide in the sampling box 2, so that the two tension springs 3d are stretched, the push plate 3a pushes the two ejector rods 3b to further push the two clamping knives 4 to rotate around the device, and the two clamping knives 4 are opened by a certain angle. When ejector pin 3b promoted to press from both sides sword 4, press from both sides sword 4 pulling elasticity pull ring 7, press from both sides to aim at the sample tissue between the sword 4 and open certain angle, take a sample to the sample tissue, then two extension springs 3d shrink make ejector pin 3b not with the clamp sword 4 contact that corresponds, two elasticity pull rings 7 shrink simultaneously and stimulate two clamp sword 4 directions and rotate, take a sample to the sample tissue and withdraw to sample box 2.
It should be understood that the above-described embodiments are merely preferred embodiments of the invention and the technical principles applied thereto. It will be understood by those skilled in the art that various modifications, equivalents, changes, and the like can be made to the present invention. However, such variations are within the scope of the invention as long as they do not depart from the spirit of the invention. In addition, certain terms used in the specification and claims of the present application are not limiting, but are used merely for convenience of description.

Claims (2)

1. The utility model provides a special sampler of alimentary canal tumour biopsy tissue, which comprises a conduit (1), sample box (2), sampling mechanism (3) and a pair of double-layered sword (4), sample box (2) sets up at conduit (1) head through two pivot (6), the face of cylinder of conduit (1) head is provided with sample connection (5), the head of sample box (2) and the sample connection (5) laminating on conduit (1), two pivot (6) pass sample box (2) and insert and establish the both ends of sample connection (5) length direction, a pair of double-layered sword (4) symmetry sets up the head at sample box (2), the afterbody of every double-layered sword (4) all can the pivoted cover establish on pivot (6) of corresponding position, sampling mechanism (3) set up in sample box (2) and conduit (1);
the sampling mechanism (3) comprises a push plate (3a), a push rod (3c) and a pair of ejector rods (3b), the push plate (3a) is arranged in the sampling box (2) through two tension springs (3d), two ends of the two tension springs (3d) are respectively fixedly connected with the tail part of the sampling box (2) and the push plate (3a), the top part of the push rod (3c) is vertically arranged on one side, away from the clamping knife (4), of the push plate (3a) and penetrates through the tail part of the sampling box (2) to extend outwards to the center of the guide pipe (1), the pair of ejector rods (3b) are respectively and vertically fixed at two ends of the push plate (3a) in the length direction with one side, close to the clamping knife (4), of the push plate (3a), and the tops of the two ejector rods (3b) are respectively abutted against the middle positions, located on the inner side surface of the sampling box (2), of the two corresponding clamping knives (4);
one side, located on the inner side of the sampling box (2), of each of the two clamping knives (4) is connected with the inner wall of the sampling box (2) through an elastic pull ring (7), and two ends of each elastic pull ring (7) are respectively arranged in the sampling box (2) through a buckle (8) and each buckle (8) on each clamping knife (4) is respectively arranged on the corresponding positions of the sampling box (2) and the clamping knife (4);
the tail parts of the push rod (3c) and the sampling box (2) are provided with wire buckles (9), the wire buckles (9) on the push rod (3c) and the sampling box (2) are connected through a pull rope (10), one end of the pull rope (10) is tightly tied to the wire buckle (9) on the push rod (3c), and the other end of the pull rope (10) penetrates through the wire buckles (9) on the sampling box (2) and extends out of the tail part of the guide pipe (1).
2. The sampler special for digestive tract tumor biopsy tissue according to claim 1, characterized in that the top end of the head of the catheter (1) and the circumference direction thereof are provided with a plurality of illuminating lamps (11) and cameras (12), wherein one camera (12) is opposite to the sampling port (5).
CN201910327971.XA 2019-04-23 2019-04-23 Special sampler of alimentary canal tumour biopsy tissue Expired - Fee Related CN109998602B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910327971.XA CN109998602B (en) 2019-04-23 2019-04-23 Special sampler of alimentary canal tumour biopsy tissue

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910327971.XA CN109998602B (en) 2019-04-23 2019-04-23 Special sampler of alimentary canal tumour biopsy tissue

Publications (2)

Publication Number Publication Date
CN109998602A CN109998602A (en) 2019-07-12
CN109998602B true CN109998602B (en) 2022-02-08

Family

ID=67173685

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910327971.XA Expired - Fee Related CN109998602B (en) 2019-04-23 2019-04-23 Special sampler of alimentary canal tumour biopsy tissue

Country Status (1)

Country Link
CN (1) CN109998602B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111588413B (en) * 2020-05-19 2021-08-03 郴州市第一人民医院 Portable oropharynx swab

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110124961A1 (en) * 2006-05-16 2011-05-26 David Zimmon Automated actuator for spring based multiple purpose medical instruments
CN201234986Y (en) * 2008-08-11 2009-05-13 徐重人 Biopsy pliers
CN204618305U (en) * 2015-04-20 2015-09-09 江苏安特尔医疗科技有限公司 Portable type disposable endoscope biopsy forceps
CN204839666U (en) * 2015-07-01 2015-12-09 杜顺达 Surgery operation is with multi -functional titanium clamp scissors
CN205107768U (en) * 2015-11-20 2016-03-30 于峰 Sampler for digestive tract tumor biopsy
CN105615930A (en) * 2016-04-04 2016-06-01 王茂玉 Specific sampler for gastrointestinal tumor biopsy tissue
CN106361380A (en) * 2016-08-31 2017-02-01 杭州富阳精锐医疗科技有限公司 Disposable use biopsy forceps
CN207804282U (en) * 2017-09-14 2018-09-04 遵义医学院附属医院 A kind of sampler of tumor of base of skull

Also Published As

Publication number Publication date
CN109998602A (en) 2019-07-12

Similar Documents

Publication Publication Date Title
CN105686855A (en) Continuous-sampling biopsy forceps
CN205831834U (en) A kind of activity pincers for puncturing
CN201861674U (en) Endoscopic multi-angle sampling device
CN207075919U (en) A kind of endoscopic surgery puncture needle
CN109998602B (en) Special sampler of alimentary canal tumour biopsy tissue
CN110403567B (en) Magnet and 'wheat and mango' bionic combined power down reverse colon examination device
CN217525290U (en) Variable angle's nipper for digestive endoscopy
CN209252978U (en) A kind of enteral surgical retractor
CN205514705U (en) Continuous sampling biopsy forceps
CN205514703U (en) Special sampler of alimentary canal tumour biopsy tissue
CN212788658U (en) Device for taking out foreign matters in digestive tract
CN202223270U (en) Cutting-type puncture biopsy needle under electronic endoscope
CN1094749C (en) Multi-function suction device for medical use
CN212996375U (en) Mouth strutting arrangement is used in intestines and stomach detection
CN204181656U (en) The disposable gastroscope biopsy forceps improved
Waye REMOVAL OF FOREIGN BODIES FROM THE UPPER INTESTINAL TRACT WITH FIBEROPTIC INSTRUMENTS.
CN203662812U (en) Device used for taking out diseased tissue cut off in minimally invasive surgery
CN114533149A (en) Biopsy forceps for bladder cancer biopsy
CN215306559U (en) Foreign matter safe storage and catching device for outer sliding sleeve structure of digestive endoscopy
CN221331399U (en) Foreign matter and tumor body taking-out device under endoscope
CN208464140U (en) A kind of stomach and intestine living body sampling sample pickup tongs
KR101931242B1 (en) Mouthpiece for medical treatment
CN209808293U (en) Protective sleeve for biopsy plug of digestive endoscopy
CN217013981U (en) Gastrointestinal endoscope inspection device
CN204600544U (en) Locking type disposable endoscope biopsy forceps

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20220208