CN109998560A - Separation power supply Dynamic Blood Glucose Monitoring transmitter, system and signal sampling method - Google Patents

Separation power supply Dynamic Blood Glucose Monitoring transmitter, system and signal sampling method Download PDF

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Publication number
CN109998560A
CN109998560A CN201910366312.7A CN201910366312A CN109998560A CN 109998560 A CN109998560 A CN 109998560A CN 201910366312 A CN201910366312 A CN 201910366312A CN 109998560 A CN109998560 A CN 109998560A
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CN
China
Prior art keywords
module
battery
transmitter
sensor
adc
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Granted
Application number
CN201910366312.7A
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Chinese (zh)
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CN109998560B (en
Inventor
钱成
肖林春
卞庆祥
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Diascience Medical Co Ltd
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Diascience Medical Co Ltd
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Priority to CN201910366312.7A priority Critical patent/CN109998560B/en
Publication of CN109998560A publication Critical patent/CN109998560A/en
Priority to PCT/CN2020/087965 priority patent/WO2020221331A1/en
Priority to ES202190028U priority patent/ES1282999Y/en
Priority to CZ202139300U priority patent/CZ35661U1/en
Priority to DE202020005637.5U priority patent/DE202020005637U1/en
Priority to ATGM50219/2021U priority patent/AT17919U1/en
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Publication of CN109998560B publication Critical patent/CN109998560B/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6832—Means for maintaining contact with the body using adhesives
    • A61B5/6833—Adhesive patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6848—Needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6848—Needles
    • A61B5/6849—Needles in combination with a needle set
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
    • A61B2560/0443—Modular apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted

Abstract

It include transmitter and sensor base device in structure the invention discloses separation power supply Dynamic Blood Glucose Monitoring transmitter, system and signal sampling method；Sensor base device is divided into pedestal and adhesive plaster, there is battery case and groove in pedestal, battery is installed in battery case, rotating seat is installed, rotating seat side is articulated in groove, has silica gel seat in rotating seat in groove, a pair of conductive rubber is provided in the silica gel seat, transmitter includes circuit board module, and there are four conductive pins for tool on circuit board module, can contact the positive and negative anodes and two conductive rubbers of battery.Compared with prior art, the present invention can separate button cell from transmitter, it is combined with sensor, when being not used, transmitter is also not loaded into sensor base, therefore, transmitter is in off-position, button cell also non-power consumption, when use, transmitter buckles into sensor base, and the battery in sensor base is powered by electrical connection to transmitter.

Description

Separation power supply Dynamic Blood Glucose Monitoring transmitter, system and signal sampling method
Technical field
The present invention relates to a kind of separation power supply Dynamic Blood Glucose Monitoring transmitter, system and signal sampling methods, and belonging to can wear Wear the field of medical instrument technology.
Background technique
Traditional dynamic glucose transmitter mainly consists of three parts, button cell, wiring board and plastic shell.Because of waterproof Demand and volumetric constraint generally place button cell and wiring board in the transmitter together, usually by the two one plastic packaging at Type, therefore transmitter battery is non-exchange, and disposable sensor was generally differed at 3-14 days using the time, having used will give up It abandons when battery life use finishes, transmitter can not reuse substantially.And from cost angle, transmitter plastic shell and wiring board Cost is much larger than battery cost, and transmitter plastic shell and wiring board service life are also much larger than battery life.Therefore this mode Meeting significant wastage wiring board and plastic shell increase Material Cost and waste.
Cost waste problem can be improved using polymer charged lithium cells, but polymer battery can have asking for loss Topic, after considering charging times, the service life is still far below the service life of wiring board and plastic shell, cannot fundamentally solve State problem.Along with polymer rechargeable battery is not suitable for the standardized product of transmitter, it usually needs battery supplier carries out The nonstandard supply of material increases buying difficulty.
In addition, reducing cost and waste to efficiently use transmitter line plate and plastic shell service life.It would generally select The button cell of volume slightly larger (electricity is bigger), the volume that so again cannot design transmitter is smaller, reduces wearing experience Property.
To solve the above-mentioned problems, using a kind of suitable mode, battery is separated from transmitter, makes wiring board Do not limited by battery life with plastic packaging shell service life, on the one hand to reduce cost and waste just seem very significant, separately On the one hand, the battery of smaller volume can be selected, system bulk is reduced, improves and wears experience.
In addition, dynamic glucose transmitter is to calculate blood sugar concentration by sampling sensor current value, therefore sample Sensor accuracy, which directly influences, calculates blood sugar concentration precision, and built-in ADC sampling electricity is generally had in wireless SOC module Road, the circuit precision are usually nominally 10~12 or so, and effective accuracy might be slightly below nominal value.If necessary to more high-precision Degree then needs to increase expensive external adc circuit.
Summary of the invention
The technical problem to be solved in the invention be in view of the above shortcomings of the prior art, and provide it is a kind of separation power supply Dynamic High-accuracy blood sugar monitoring transmitter, system and signal sampling method.
In order to solve the above technical problems, the technical solution adopted by the present invention is that:
A kind of separation power supply Dynamic Blood Glucose Monitoring transmitter, including transmitter and sensor base device；The sensor Base device includes pedestal and adhesive plaster, and pedestal is located on adhesive plaster；The pedestal top is opening, and pedestal is interior with battery case and recessed Slot is equipped with battery and battery cover in the battery case, and rotating seat is equipped in the groove, and rotating seat depends on the one of battery case Side is articulated in groove, has silica gel seat in rotating seat, is provided with a pair of conductive rubber in the silica gel seat, through-silicon rubber base and Rotating seat is provided with sensor, and sensor may pass through two conductive rubbers, and the groove has opening, institute by the side of battery case It states adhesive plaster and offers hole, sensor may pass through the hole of opening and adhesive plaster；The transmitter includes plastic shell and circuit board module, The plastic shell is covered on pedestal, and the circuit board module is mounted on plastic shell inner top, is had on circuit board module Four conductive pins can contact the positive and negative anodes and two conductive rubbers of battery.
Scheme as a further preference is provided with the first conductive rubber hole and the second conductive rubber on the silica gel seat Hole, two conductive rubbers are separately mounted in the first conductive rubber hole and the second conductive rubber hole；It is also set up in the silica gel seat There are two square hole, two conductive rubbers and two square holes are linearly distributed, and the sensor passes through two conductive rubbers.
Scheme as a further preference, the two sides in the groove respectively offer a semicircle orifice, the rotating seat End two sides are respectively provided with the extension bar of a toughness, and the outside of extension bar has a cylindrical shaft, and cylindrical shaft is placed in semicircle orifice Rotation.
Scheme as a further preference is separately installed with an electrode adapter on the positive and negative anodes of the battery, each An electrode connecting parts are configured on electrode adapter, are opened up on the battery cover there are two circular hole, a circular hole corresponds to an electricity Pole connector, electrode connecting parts pass through circular hole portion and are placed in outside battery cover.
Scheme as a further preference, four conductive pins on the circuit board module are two battery guide pins and two A rubber guide pin, two battery guide pins are separately connected an electrode connecting parts, and two rubber guide pins are separately connected a conductive rubber Glue.
The end of scheme as a further preference, the pedestal has pedestal snap open, the end of the plastic shell Portion has the edge lug boss for being inserted in pedestal snap open；The side of plastic shell has shell card slot, the inside of the groove There is the Elastic buckle for being caught in shell card slot on wall.
The circle of edge one of scheme as a further preference, the battery case has sealing strip, the edge of the silica gel seat One circle has muscle position.
The system of separation power supply Dynamic Blood Glucose Monitoring transmitter, including LC filter energy-storage module, wireless SOC module, function Circuit power module, sensor excitation and conditioning module, ADC precision enhancing module, battery and sensor, the anode of the battery Pass through connection LC filtering energy-storage module respectively with cathode, has between LC filtering energy-storage module and the vdd terminal of wireless SOC module There is connecting line, there is double control switch on the connecting line, double control switch can connect the end Da or the functional circuit power supply of wireless SOC module Module, functional circuit power module connection sensor excitation and conditioning module, the end Db of the wireless SOC module also route Connect sensor excitation and conditioning module, wireless SOC module has a built-in ADC module, the end Dc of wireless SOC module and built-in ADC module is all connected with ADC precision enhancing module, and ADC precision enhances module circuitry connection sensor excitation and conditioning module, sensing The positive and negative anodes of device excitation and conditioning module distinguish connection sensor.
A kind of high-precision signal method of sampling of ADC precision enhancing module, which is characterized in that include the following steps, step One: injecting the noise voltage that an amplitude is 0 in sampled signal, carry out ADC sampling, result Read1；Step 2: sampling letter An amplitude is injected in number isNoise voltage, wherein VADC_REFFor ADC reference voltage, d is aimed at precision digit, Carry out ADC sampling, result Read2；Step 3: final result Read=(Read1+Read2)/2, obtained result precision can Enhancing 1.
Compared with prior art, the beneficial effects of the present invention are: button cell is separated from transmitter, and sensing Device placement combines.When being not used, transmitter is also not loaded into sensor base, and therefore, transmitter is in off-position, Button cell also non-power consumption.When in use, transmitter buckles into sensor base, the battery in sensor base is by electrically connecting It connects and powers to transmitter.When after use, removing transmitter, button cell is discarded together with sensor.In this way, button cell is only The electricity of sensor a cycle need to be supported.On the one hand the volume of button cell can be reduced, on the other hand, can reduce battery at This.Further, since transmitter can reuse, cost will also be greatly reduced.
Newly-designed ADC precision enhances circuit, can make sampling precision that can enhance 1；LC filters accumulator, on the one hand may be used To reduce battery capacity (volume), transmitter power supply on the other hand can be made more stable；And wireless SOC module power supply and function Energy circuit power supply separates power supply mode, effectively reduces power consumption.And devising the soft method powered on makes transmitter work more Add reliable and stable.
Detailed description of the invention
Fig. 1 is the structural diagram of the present invention；
Fig. 2 is transmitter explosive view；
Fig. 3 is sensor base device explosion figure；
Fig. 4 is the cross-sectional view of silica gel seat；
Fig. 5 is the structural schematic diagram of pedestal；
Fig. 6 is structure of battery corer schematic diagram；
Fig. 7 is rotating seat and silica gel holder structure schematic diagram；
Fig. 8 is system module schematic diagram of the invention；
Fig. 9 is functional circuit module circuit diagram；
Figure 10 is the soft upper electrical schematic of functional circuit power supply；
Figure 11 is sensor excitation and conditioning module circuit；
Figure 12 is that ADC precision enhances modular circuit；
Figure 13 is that LC filters energy storage modular circuit；
Figure 14 is wireless SOC module circuit.
Specific embodiment
The optimal technical scheme that the invention will now be described in detail with reference to the accompanying drawings.
As shown in Figure 1, ejector system distributes emitter 200 and 300 two parts of sensor base device composition from structure. The sensor electrode 301 connected on sensor base device 300 can be by assisting implanted device to be implanted in receptor tissue.Auxiliary Implanted device can be found in published patent CN206424078U.
As shown in Fig. 2, transmitter 200, hardware includes circuit board module 201 and plastic shell 202.Transmitter size is about 32mm*16mm*5mm is conveniently affixed on receptor skin, carries after being packed into sensor base device 300.
The circuit board module 201, includes four conductive pins, and conductive pin generally uses conductive metal, preferably brass. Conductive pin is drawn from plastic shell 202, is flushed with plastic shell bottom surface.When transmitter 200 snaps into sensor base device After 300, conductive pin is connected with sensor S+, S- and battery V+V- respectively.Battery 304 in sensor base 300 can be to hair Emitter 200 is powered, and the signal value measured from sensor 301 can be converted into corresponding physiological parameter, be sent to by transmitter 200 User receiving end.
Plastic shell 202, it is fully wrapped around, it can be achieved that waterproof action by circuit board module (in addition to 4 conductive pins).Plastic packaging There is edge lug boss 2021 on the left of shell, respectively there are a shell card slot 2022 in two sides, after transmitter is packed into sensor base, Transmitter 200 can be fixed on the base by edge lug boss 2021 and shell card slot 2022
Such as Fig. 3, sensor base device 300 mainly includes battery 304 and sensor 301.Wherein battery 304 and transmitter 200 are connected by electrical contact V+ with V-.Sensor 301 is connected with transmitter 200 by electrical contact S+S-.
Sensor base device 300 include sensor 301, pedestal 302, adhesive plaster 303, battery 304, battery adapter 305, Electrode connecting parts 306, battery cover 307, the waterproof grommet 308 of battery connecting piece, rotating seat 309, silica gel seat 310, conductive rubber Glue etc. 311.
Battery adapter 305 can be the metal parts such as nickel strap.Battery adapter 305 is connect with battery 304 and battery Part 306 is connected with by modes such as welding.
Battery 304, outside batteries are equipped with insulating paper, battery plus-negative plate are prevented to be connected.
Battery connecting piece 306 is placed on battery adapter 305, and the installation by battery cover 307 is compressible.
Battery connecting piece 306 has elasticity, can carry out elastomeric electrical with transmitter and connect.Preferably, battery connecting piece 306 It can be spring pin, inside is equipped with spring, when transmitter 200 is packed into, the contact of battery connecting piece is pushed, to guarantee Battery connecting piece contact and transmitter contact reliable contacts.
There is a circle waterproof grommet 308 on pedestal 302, surface, and waterproof grommet can be silica gel, the elasticity material such as TPE, TPU Material.Waterproof grommet can be directly injection-moulded on pedestal, can also be bonded on pedestal by the later period.Waterproof grommet is trapezoidal Or triangle, transmitter can be preferably disposed, and can better waterproof.After in conjunction with transmitter bottom plane, it can play Waterproof action, waterproofing grade can reach IPX7.
Under unused state, transmitter 200 is also not loaded on sensor base device 300, and therefore, transmitter 200 is in Off-position, the also non-power consumption of battery 304.When in use, transmitter 200 buckles on sensor base device 300, sensor base Battery on device 300 is powered by electrical connection to transmitter 200.When after use, removing transmitter, 304 simultaneous interpretation of battery Sensor is discarded together.
As shown in figure 4, sensor 301 is implanted into organism subcutaneous tissue, for sensing the original signal of analyte.Sensing Device 301 includes at least 1 working electrode and a reference electrode.Working electrode and reference electrode S+S- pass through conductive rubber respectively 311 and transmitter 200 battery guide pin 2011 and rubber guide pin 2012 realize electrical connection.
On the one hand pedestal 302 is fixed on receptor skin by the adhesive plaster 303 of non-woven fabrics material, on the other hand for solid Surely transmitter 200 is connected.
As shown in figure 5, pedestal 302, there is the battery case 3021 of a φ 12mm at middle part, is used for placing battery 304.Battery is positive and negative Pole is connected to battery connecting piece 306 by battery adapter 305, then guides to base outer surface by battery connecting piece.
Pedestal 302, end are equipped with a pedestal snap open 3023.Open top is plane, and bottom is equipped with certain angle Inclined-plane.Top surface is used for and the edge lug boss 2021 of transmitter 200 cooperates, and limits transmitter.Bottom bevel is convenient for transmitter peace Dress.
Pedestal 302, right part have a groove 3024, and the groove is for placing rotating seat 309.After sensor 301 is implanted into, rotation Swivel base rotates clockwise certain angle, is finally bonded with groove floor.3024 lower left side of groove has an opening 3025, passes Sensor 301 can pass through from the opening.
3024 two sides of groove are respectively provided with a semicircle orifice 3026, and the cooperation of cylindrical shaft 3092 of semicircle orifice and rotating seat 309 makes Obtaining rotating seat can rotate along the axially bored line.
Inclined-plane is equipped with above semicircle orifice 3026, which is caught in semicircle orifice for the ease of rotating seat cylindrical shaft.
302 two sides of pedestal are equipped with Elastic buckle 3027, and Elastic buckle is used for and the shell card slot 2022 of transmitter two sides is matched It closes, when transmitter is packed into, the Elastic buckle of pedestal two sides is flared out, and after transmitter is packed into place, Elastic buckle is retracted.Bullet Property buckle bottom surface and transmitter card slot it is stuck, limitation transmitter move.
As shown in fig. 6, battery cover 307, for cooperating with pedestal 302, fixed battery connecting piece 306 and battery 304.Electricity Battery cover groove 3071 is equipped among pond lid 307, for accommodating battery 304.Respectively there is a cylindrical hole step surface 3072 at both ends, lead to 2 cylinder steps 3022 cooperation corresponding with base end face is crossed, so that battery connecting piece is fixed.2 circles at 307 top of battery cover Hole 3073 can make the elastomeric element of battery connecting piece pass through, so as to contact with transmitter contact.
As shown in fig. 7, the rotating seat 309, on the one hand, under non-installation condition, provided to silica gel seat 310 thereon Support；On the other hand, it when being installed, can be rotated around pedestal to installation condition.
There are 2 extension bars 3091 in 309 two sides of rotating seat, which has certain elasticity, can be inside when extension bar stress It shrinks side；After applied force is cancelled, extension bar can be restored to original position.
Boom end respectively has 1 cylindrical shaft 3092 out, cooperates with pedestal semicircle orifice.
Cylindrical shaft 3092, side have an inclined-plane, and when rotating seat is packed into pedestal, cylindrical shaft inclined-plane connects with pedestal inclined-plane Touch guiding.Under extruding force effect, extension bar 3091 is shunk inwardly, and cylindrical shaft is caught in pedestal semicircle orifice, and extension bar Original position can be restored to.Rotating seat and base portion freedom degree are limited at this time, and rotating seat can only be rotated around cylinder axis.
Silica gel seat 310, on the one hand, be used to store conductive rubber 311, provide deformation space to conductive rubber and limit conduction Rubber；On the other hand, after silica gel seat is in conjunction with transmitter plane, waterproof action can be played, waterproofing grade can reach IPX7.
There are the first conductive rubber hole 3101 and the second conductive rubber hole 3102 in the silica gel seat 310, centre.The circular hole is used To place conductive rubber 311.
The conductive rubber 311 shares 2, after the completion of implantation, and sensor 301 passes through conductive rubber, each conduction rubber Glue respectively with sensor 301 and transmitter 200 electrical contact S+, S- connection, thus realize sensor and transmitter it Between elastomeric electrical connection.Conductive rubber is except when circuit connection effect is outer, and under pressure, by frictional force, holding is passed The position of sensor.
The silica gel seat 310, there are also 2 square holes 3103.The purpose of square hole is to reduce guide pin and wear Pricker withdraws resistance when silica gel seat.
The silica gel seat 310, top have a circle trapezoidal or the muscle position 3104 of triangle, which can make transmitter Installation is lighter, and can better waterproof.
Before use, rotating seat 309 and the arrangement at 45 ° of pedestal 302, the hollow guide pin in implanting device is parallel across rotation Seat 309 and silica gel seat 310, and pass through the first conductive rubber hole 3101 and the second conductive rubber hole 3102；Hollow puncture needle In guide pin, needle point is the solid needle body of soft material for puncturing receptor skin, sensor 301, is located at puncture needle It is interior.In use, by the driving force of implanting device, puncture needle is made to enter human body with sensor 301, can extract out later puncture needle with And guide pin, it remaines in sensor 301 in human body, finally dismantles implanting device, transmitter 200 is mounted on pedestal 302.This When, the battery on pedestal is powered by the battery guide pin 2011 being connected with V+V- to transmitter.The rubber being connected with transmitter S+S- Glue guide pin 2012, conductive rubber 311 and sensor 301 form an electric loop.When the glucose oxidase on sensor When reacting with the glucose inside receptor, faint electric current can be generated.Transmitter can be measured by above-mentioned electric loop Current value.And measured current value is converted to by receptor blood glucose value by transmitter internal algorithm.Then by wirelessly passing Blood glucose value is transferred in corresponding display equipment by defeated module.
As shown in figure 8, VDD is the supply voltage of SOC in SOC module, Da, Db, Dc are SoC module digital output pin. Da pin is used for the disconnection and closure of control switch S1, controls whether battery powers to functional circuit power module with this.Db is used In the level of selection sensor excitation circuit, sensor excitation module can be made to provide high level and two kinds of low level to sensor Driving voltage signal.Dc is used to inject noise signal to ADC precision enhancing module.Ain1 and Ain2 is ADC input, for sampling ADC precision enhances the sensor voltage after improving and noise injects of module output.
As shown in figure 9, Q2 (the switch S1 corresponding to Fig. 1) realizes switch S1 functions of modules.Its gate pole VPER_SHDN is (right Should be in the Da signal of Fig. 1) it is connected to the Pin37 of bluetooth main control chip U0 in wireless SOC module circuit.
When VPER_SHDN is low level, VBAT and V_PER conducting.Battery starts to include sensor excitation to functional circuit And conditioning module circuit and ADC precision enhancing modular circuit start to power.
When VPER_SHDN is high level, VBAT and V_PER are disconnected, and functional circuit includes sensor excitation and conditioning module Circuit and ADC precision enhancing modular circuit do not work, and can save power consumption.L1, L2 inductance mainly divide digital circuit and simulation Circuit, since analog circuit signal belongs to tiny signal sampling, the segmentation of digital and analog circuit can guarantee analog signal more Add clean.U1 is Precision reference power supply, and precision is one thousandth, inputs as analog power VCCA, exports as benchmark voltage signal VS_REF, VS_REF are used as the reference level for applying sensor excitation.C1, C2 are power filtering capacitor.
Present invention employs being powered on to functional circuit power supply is soft, when functional circuit needs to work on power, wireless SOC module Apply the PWM chopped waveform of a long t of timing to Q2 gate pole, such as Figure 10, PWM duty cycle is gradually increased, at this time analog switch Output voltage slowly rises, and electric current can maintain a smaller value range between voltage rising period, size of current and PWM weeks Phase and duty ratio have relationship.Can be according to PWM perdurabgility using the soft size of current that powers on for powering on mode of PWM, duty is when PWM cycle adjustment, institute in this way under.If do not use it is soft power on, but directly adopt and allocated to one height of Q2 gate pole, firmly The mode opened, due to there is a large amount of filter capacitor in functional circuit, momentary charge electric current (and pulse current form) at this time Often very big, the capacity in possible LC filter capacitor is inadequate, will lead to cell voltage and drags down, and makes system that deficient reset occur existing As.
As shown in figure 11, R1, R2, R3, R4, R5, R6, Q1, U5 constitute sensor excitation circuit, and the gate pole of Q1 is connected to nothing The Pin39 of bluetooth main control chip U0 in line soc module.Sensor excitation circuit output VS+ is connect by transmitter electrical contact S+ Sensor anode.VS_REF is the Precision reference voltage source output in functional circuit power module.Export the meter of VS+ and VS_REF Calculation relationship is as follows,
When VS_SEL (the Db signal corresponding to Fig. 1) is high level:
Wherein, R4//R5 indicates R4, R5 parallel equivalent resistance value
When VS_SEL (the Db signal corresponding to Fig. 1) is low level:
R7, R8, C5, U6 form conditioning circuit, are substantially I-V computing circuit, and effect will mainly flow into the electric current of VS- Signal is converted to voltage signal ADC_GLU and is converted to digital signal for ADC module.The Pin3 of U6 passes through transmitter electrical contact S- It is connected to sensor cathode, according to amplifier analysis method, it is known that the voltage of S- should be equal with VS_REF.C3 and C39 is U5, U6 electricity Source decoupling capacitor.C8 is filter capacitor, controls the noise bandwidth of circulating current signal.
Assuming that the sensor current for flowing into S- is I0, ADC_GLU and input I0Relationship are as follows:
ADC_GLU=VS_REF+I0*R8
Since the electric current of sampling is microampere rank, R8 is preferably 1M Ω.
Analog to digital conversion circuit ADC its precision built in general main control chip is fixed, limited, sometimes often not It is able to satisfy application demand.Usual solution is to use the outer ADC chip of a plug-in block piece, but the outer ADC of piece is typically relatively expensive. For this purpose, this example has invented ADC precision enhancing circuit module, ADC precision enhances circuit and uses noise injection method, can be wireless On the basis of the built-in ADC of SOC module main control chip fixed precision, sampling precision enhances 1 again.The method of sampling are as follows: first It walks, the noise voltage that one amplitude of injection is 0 in sampled signal carries out ADC sampling, result Read1；Step 2, sampled signal One amplitude of middle injection isNoise voltage (VADC_REFFor ADC reference voltage, d is aimed at precision digit), carry out ADC Sampling, result Read2；Step 3, final result Read=(Read1+Read2)/2, obtained result precision can enhance 1.
As shown in figure 12, it is sampled in sampled signal two-stage noise signal injected above, is averaged after sampling respectively Afterwards, precision can increase by 1 bit resolution.
The circuit for injecting noise signal realizes that every road sampling needs an adder operation circuit using adder operation circuit. As the precision of figure, U8, R13, R14, R15, the pairs of VS_REF of R16 group enhances circuit.U9, R17, R18, R19, R20 group are pairs of The precision of ADC_GLU enhances circuit.Every road ADC precision enhancing circuit structure is the same.Precision enhances circuit warp Output ADC_R and ADC_G is connected to the bluetooth in wireless SOC module after the rear class filtering circuit filtering of R9R10C8C9C10 composition Analog-to-digital conversion is carried out on built-in ADC the pin Pin41 and Pin42 of main control chip U0.Bit11 (the Dc signal corresponding to Fig. 1) is Noise Injection Signal is connected to the Pin38 of U0.The signal of injection only has height to allocate 3V or low level 0V.
By taking the road VS_REF as an example, R is enabled13=k*R14, R19=k*R20, soWherein k= 2d.At ADC available accuracy 10, aimed at precision 11, k should take 2048 proximity values.
Step1:Bit11 exports low level, VBit11=0, carry out ADC sampling, result Read1；
Step2:Bit11 exports high level, VBit11=3, carry out ADC sampling, result Read2；
Step3: final result Read=(Read1+Read2)/2, the as result after enhancing precision.
In this example, ADC standard handovers precision 10 of the bluetooth main control chip when over-sampling does not occur, reference voltage presses 1 (100%) it calculates, precision isIf result register is 12 bit registers, as a result a high position is aligned in result register. After 1 table 2 of table provides signal injection, the calculating process of precision enhancing.
1. 10 ADC and 11 ADC coding schedules of table
Table 2.ADC precision enhances signal calculated example table
By table 2, it is known that, by injecting (superposition) noise signal by method on sampled voltage signal, to each note Enter the summation of noise signal sampled result, then after average computation, the result of acquisition can increase by 1 sampling precision.
As shown in figure 13, LC filters accumulator, can select the button cell of more low capacity (volume), nothing is effectively reduced Influence of pulse current of the line SOC module when radio-frequency event occurs to cell voltage, keeps transmitter power supply more stable, accordingly Pulse current pair of the wireless SOC module when radio-frequency event occurs is effectively reduced in the battery that can choose more low capacity (volume) The influence of cell voltage keeps transmitter power supply more stable, can choose the battery of more low capacity (volume) accordingly；
LC is filtered in accumulator, and V+V- connects battery plus-negative plate, and VDD_NRF is to the bluetooth master control core in wireless SOC module Piece power supply.
L6, C34, C35, C36, C37 constitute LC and filter accumulator.Since the discharge capability of battery is related to capacity, often Rule, general low capacity CR series button cell pulsed discharge ability is 5mA or so, and Bluetooth chip is when occurring radio-frequency event (when wireless transmission data or reception data), current loading is up to 12mA or more, considerably beyond cell pulse discharge ability.
When cell pulse discharge scarce capacity, battery both end voltage can be dragged down, when brownout, bluetooth master can be made Control chip resets, and whole system owes electric fault.On the other hand, pulse current repeatedly will also result in damage to battery itself Wound, i.e. pulse current can make the actual motion capacity of battery much smaller than nominal capacity.
Consider that radio-frequency event is intermittent, therefore this example increases inductance capacitor filtering accumulator, when non-pulsing When electric current, C34, C35, C36, C37 main function is energy storage, when not occurring the radio frequency time, entire circuit power consumption very little, therefore Battery is greater than capacitor to capacitor charging and discharges circuit system, and extra energy storage is in capacitor.When radio-frequency event occurs, The pulse current that circuit system needs preferentially is obtained from capacitor, therefore battery does not need to provide pulse current, to make battery In the entire duty cycle, all in more gentle discharge condition, effectively inhibit Voltage Drop event, and prevent pulse current pair The damage of battery.
Inductance L6 is mainly to inhibit battery to the current amplitude of capacitor charging, because pulse current is high frequency characteristics electric current, Big impedance operator can be presented to high frequency in inductance L6.When pulsing electric current, L6 can make battery discharge prior to battery discharge, I.e. preferentially using the electricity stored in capacitor.
As shown in figure 14, wireless SOC module circuit, the preferred Bluetooth chip U0 of this example is as main control chip.
Wireless SOC module power supply and functional circuit power supply separate, respectively independently-powered.Functional circuit power supply master To enhance circuit power supply for sensor excitation and conditioning circuit and precision.Using the method for separated power supply, worked according to whom, The principle of whose power supply.When functional circuit is not necessarily to work, battery capacity can not be consumed, power consumption is effectively reduced.In order to make function Circuit reliably powers on, and devises the soft method powered on, effectively inhibits the pulse current amplitude of powered on moment, transmitter is made to work It is relatively reliable.
Capacitor C27, C28 and crystal Y1 provide high frequency clock source, the preferred 16MHz of crystal Y1 for Bluetooth chip.Capacitor C21, C22 and crystal Y2 provides low-frequency clock source, the preferred 32.768kHz of crystal Y2 for Bluetooth chip.
DV, DIO, DCK, DG are artificial mouth, for emulating and programming program.C23, C24, C25, C26, C29, C30, C33 For Bluetooth chip power supply coupling capacitor.L4, C31 and antenna ANT1 constitute Bluetooth RF circuit, for modulating wireless signal.
The Pin37 of U0 is connected to the gate pole of switch S1 circuit Q2, the on-off for control function circuit power.When not needing When functional circuit works, low level is exported, functional circuit is in off position at this time, achievees the purpose that save power consumption.
Pin41, Pin42 of U0 is the sensor current sampled signal by ADC precision reinforcing module circuit, for calculating Blood sugar concentration.
The Pin6 of U0 is connected to anode, acquires the voltage value of battery, based on the voltage-capacity curve according to battery Calculate the electricity of battery.
The Pin39 of U0 is connected to the gate pole of Q1 in sensor excitation and conditioning module circuit, for selecting sensor to apply The level of excitation can apply the excitation of two-stage level by a mosfet in this example for sensor.
Above-described specific embodiment has carried out further the purpose of the present invention, technical scheme and beneficial effects It is described in detail, it should be understood that being not limited to this hair the foregoing is merely a specific embodiment of the invention Bright, all within the spirits and principles of the present invention, any modification, equivalent substitution, improvement and etc. done should be included in the present invention Protection scope within.

Claims (9)

1. separation power supply Dynamic Blood Glucose Monitoring transmitter, it is characterised in that: including transmitter (200) and sensor base device (300)；The sensor base device (300) includes pedestal (302) and adhesive plaster (303), and pedestal (302) is located at adhesive plaster (303) On；Pedestal (302) top is opening, has battery case (3021) and groove (3024), the battery case in pedestal (302) (3021) battery (304) and battery cover (307) are installed in, are equipped with rotating seat (309) in the groove (3024), is rotated Seat (309) is articulated in groove (3024) by the side of battery case (3021), has silica gel seat (310) in rotating seat (309), institute It states and is provided with a pair of conductive rubber (311) in silica gel seat (310), through-silicon rubber base (310) and rotating seat (309) are provided with sensing Device (301), sensor (301) may pass through two conductive rubbers (311), and the groove (3024) leans on the side of battery case (3021) With opening (3025), the adhesive plaster (303) offers hole, and sensor (301) may pass through opening (3025) and adhesive plaster (303) Hole；The transmitter (200) includes plastic shell (202) and circuit board module (201), and the plastic shell (202) is covered on On pedestal (302), the circuit board module (201) is mounted on plastic shell (202) inside, and circuit board module has on (201) Four conductive pins, the positive and negative anodes of accessible battery (304) and two conductive rubbers (311).
The Dynamic Blood Glucose Monitoring transmitter 2. separation according to claim 1 is powered, it is characterised in that: the silica gel seat (310) the first conductive rubber hole (3101) and the second conductive rubber hole (3102) are provided on, two conductive rubbers (311) are respectively It is mounted in the first conductive rubber hole (3101) and the second conductive rubber hole (3102)；It is additionally provided in the silica gel seat (310) Two square holes (3103), two conductive rubbers (311) and two square holes (3103) are linearly distributed, the sensor (301) two conductive rubbers (311) are passed through.
The Dynamic Blood Glucose Monitoring transmitter 3. separation according to claim 1 is powered, it is characterised in that: the groove (3024) Interior two sides respectively offer a semicircle orifice (3026), and the end two sides of the rotating seat (309) are respectively provided with stretching for a toughness The outside of rod (3091), extension bar (3091) has a cylindrical shaft (3092), and cylindrical shaft (3092) is placed in semicircle orifice (3026) rotation in.
The Dynamic Blood Glucose Monitoring transmitter 4. separation according to claim 1 is powered, it is characterised in that: the battery (304) Positive and negative anodes on be separately installed with an electrode adapter (305), one electrode connection of configuration on each electrode adapter (305) Part (306), opens up that there are two circular hole (3073), the corresponding electrode connections of a circular hole (3073) on the battery cover (307) Part (306), electrode connecting parts (306) pass through circular hole (3073) and are partially disposed in battery cover (307) outside.
The Dynamic Blood Glucose Monitoring transmitter 5. separation according to claim 4 is powered, it is characterised in that: the circuit board module (201) four conductive pins on are two battery guide pins (2011) and two rubber guide pins (2012), two battery guide pins (2011) it is separately connected an electrode connecting parts (306), two rubber guide pins (2012) are separately connected a conductive rubber (311)。
The Dynamic Blood Glucose Monitoring transmitter 6. separation according to claim 1 is powered, it is characterised in that: the pedestal (302) End there are pedestal snap open (3023), the end of the plastic shell (202), which has, is inserted in pedestal snap open (3023) edge lug boss (2021)；The side of plastic shell (202) has shell card slot (2022), the groove (3024) There is the Elastic buckle (3027) for being caught in shell card slot (2022) on inner sidewall.
The Dynamic Blood Glucose Monitoring transmitter 7. separation according to claim 1 is powered, it is characterised in that: the battery case (3021) the circle of edge one has sealing strip (308), and the circle of edge one of the silica gel seat (310) has muscle position (3104).
8. according to the system for arbitrarily separating power supply Dynamic Blood Glucose Monitoring transmitter in the claims 1-7, it is characterised in that: packet LC filtering energy-storage module, wireless SOC module, functional circuit power module, sensor excitation and conditioning module, ADC precision is included to increase Strong module, battery and sensor, the anode and cathode of the battery pass through connection LC filtering energy-storage module, LC filtering respectively There is connecting line between energy-storage module and the vdd terminal of wireless SOC module, there is double control switch on the connecting line, double control switch can Connect the end Da or the functional circuit power module of wireless SOC module, functional circuit power module connection sensor excitation and Conditioning module, also connection sensor excitation and conditioning module, wireless SOC module have at the end Db of the wireless SOC module Built-in ADC module, the end Dc of wireless SOC module and built-in ADC module are all connected with ADC precision enhancing module, and ADC precision enhances mould The positive and negative anodes difference connection sensing of block connection sensor excitation and conditioning module, sensor excitation and conditioning module Device.
9. a kind of high-precision signal method of sampling of ADC precision enhancing module, which is characterized in that include the following steps, step 1: The noise voltage that an amplitude is 0 is injected in sampled signal, carries out ADC sampling, result Read1；Step 2: in sampled signal Injecting an amplitude isNoise voltage, wherein VADC_REFFor ADC reference voltage, d is aimed at precision digit, is carried out ADC sampling, result Read2；Step 3: final result Read=(Read1+Read2)/2, obtained result precision can enhance 1.
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ES202190028U ES1282999Y (en) 2019-04-30 2020-04-30 Dynamic Blood Glucose Monitoring Transmitter with an Independent Power Supply
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DE202020005637.5U DE202020005637U1 (en) 2019-04-30 2020-04-30 Dynamic blood glucose measurement and transmission device with separate power supply and system
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CN114711765B (en) * 2022-06-07 2022-10-14 苏州百孝医疗科技有限公司 Continuous analyte concentration monitoring system
CN114711765A (en) * 2022-06-07 2022-07-08 苏州百孝医疗科技有限公司 Continuous analyte concentration monitoring system

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