CN109998105A - A kind of preparation method of fructus lycii flavone powder capsule - Google Patents
A kind of preparation method of fructus lycii flavone powder capsule Download PDFInfo
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- CN109998105A CN109998105A CN201910245730.0A CN201910245730A CN109998105A CN 109998105 A CN109998105 A CN 109998105A CN 201910245730 A CN201910245730 A CN 201910245730A CN 109998105 A CN109998105 A CN 109998105A
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- fructus lycii
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- 229930003944 flavone Natural products 0.000 title claims abstract description 37
- 235000011949 flavones Nutrition 0.000 title claims abstract description 37
- 239000002775 capsule Substances 0.000 title claims abstract description 31
- 239000000843 powder Substances 0.000 title claims abstract description 29
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 title claims abstract description 21
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 title claims abstract description 20
- 150000002212 flavone derivatives Chemical class 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 45
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 42
- 239000000284 extract Substances 0.000 claims abstract description 25
- 108010010803 Gelatin Proteins 0.000 claims abstract description 21
- 229920000159 gelatin Polymers 0.000 claims abstract description 21
- 239000008273 gelatin Substances 0.000 claims abstract description 21
- 235000019322 gelatine Nutrition 0.000 claims abstract description 21
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229930003935 flavonoid Natural products 0.000 claims abstract description 12
- 150000002215 flavonoids Chemical class 0.000 claims abstract description 12
- 235000017173 flavonoids Nutrition 0.000 claims abstract description 12
- 238000001035 drying Methods 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 10
- 239000003813 safflower oil Substances 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 235000019441 ethanol Nutrition 0.000 claims description 27
- 239000007901 soft capsule Substances 0.000 claims description 24
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims description 18
- 244000241838 Lycium barbarum Species 0.000 claims description 17
- 235000015459 Lycium barbarum Nutrition 0.000 claims description 17
- 150000002213 flavones Chemical class 0.000 claims description 17
- 235000015468 Lycium chinense Nutrition 0.000 claims description 16
- 235000013399 edible fruits Nutrition 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- 238000005406 washing Methods 0.000 claims description 12
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- 238000007493 shaping process Methods 0.000 claims description 10
- 235000012754 curcumin Nutrition 0.000 claims description 9
- 229940109262 curcumin Drugs 0.000 claims description 9
- 239000004148 curcumin Substances 0.000 claims description 9
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims description 9
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 claims description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- 239000003921 oil Substances 0.000 claims description 8
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- 238000007873 sieving Methods 0.000 claims description 4
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- 238000000227 grinding Methods 0.000 claims description 2
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- 239000006071 cream Substances 0.000 claims 1
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- 206010013786 Dry skin Diseases 0.000 abstract 1
- 230000003712 anti-aging effect Effects 0.000 abstract 1
- 230000004438 eyesight Effects 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 5
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 5
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 4
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 description 4
- 235000013402 health food Nutrition 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 102100020895 Ammonium transporter Rh type A Human genes 0.000 description 2
- 101100301844 Arabidopsis thaliana RH50 gene Proteins 0.000 description 2
- UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 description 2
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- 241001310146 Ilex cornuta Species 0.000 description 2
- 235000010326 Osmanthus heterophyllus Nutrition 0.000 description 2
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 2
- 101150107345 Rhag gene Proteins 0.000 description 2
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 2
- KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
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- 235000008777 kaempferol Nutrition 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 235000005875 quercetin Nutrition 0.000 description 2
- 229960001285 quercetin Drugs 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 1
- 244000163122 Curcuma domestica Species 0.000 description 1
- 235000003392 Curcuma domestica Nutrition 0.000 description 1
- -1 Flavone compound Chemical class 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 235000015463 Lycium carolinianum Nutrition 0.000 description 1
- IKMDFBPHZNJCSN-UHFFFAOYSA-N Myricetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC(O)=C(O)C(O)=C1 IKMDFBPHZNJCSN-UHFFFAOYSA-N 0.000 description 1
- PEFASEPMJYRQBW-HKWQTAEVSA-N Robinin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)C=C3OC=2C=2C=CC(O)=CC=2)=O)O1 PEFASEPMJYRQBW-HKWQTAEVSA-N 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 235000003373 curcuma longa Nutrition 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000010247 heart contraction Effects 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- DDELFAUOHDSZJL-UHFFFAOYSA-N kaempferol 3-O-rutinoside-7-O-rhamnoside Natural products OC1C(O)C(O)C(C)OC1OC1C(O)C(O)C(CO)OC1OC1=C(C=2C=CC(O)=CC=2)OC2=CC(OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C1=O DDELFAUOHDSZJL-UHFFFAOYSA-N 0.000 description 1
- PEFASEPMJYRQBW-UHFFFAOYSA-N kaempferol 7-O-alpha-L-rhamnopyradoside 3-O-beta-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(OC4C(C(O)C(O)C(C)O4)O)C=C3OC=2C=2C=CC(O)=CC=2)=O)O1 PEFASEPMJYRQBW-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 description 1
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 description 1
- 235000009498 luteolin Nutrition 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- PCOBUQBNVYZTBU-UHFFFAOYSA-N myricetin Natural products OC1=C(O)C(O)=CC(C=2OC3=CC(O)=C(O)C(O)=C3C(=O)C=2)=C1 PCOBUQBNVYZTBU-UHFFFAOYSA-N 0.000 description 1
- 235000007743 myricetin Nutrition 0.000 description 1
- 229940116852 myricetin Drugs 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000001869 rapid Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- PEFASEPMJYRQBW-XMWKPCQISA-N robinin Natural products O(C[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@H](OC2=C(c3ccc(O)cc3)Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@@H](O)[C@@H](C)O4)c3)C2=O)O1)[C@H]1[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O1 PEFASEPMJYRQBW-XMWKPCQISA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 235000021404 traditional food Nutrition 0.000 description 1
- 235000013976 turmeric Nutrition 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
To be made fructus lycii dry powder after crushing deseeding using fructus lycii as raw material the present invention relates to a kind of fructus lycii flavone powder capsule and preparation method thereof, fructus lycii dry powder through alcohol extracting, extract, be concentrated to get fructus lycii Flavonoid extract；Using Flavonoid extract as main component, fructus lycii flavone powder capsule is made by techniques such as pelleting, sizing, dryings with auxiliary materials such as safflower seed oil, gelatin, glycerol, water with it.Preparation process of the invention is scientific and reasonable, strong operability, and the fructus lycii flavone powder capsule of preparation has the health-care efficacies such as anti-oxidant, anti-aging, improving eyesight eyeshield, antiultraviolet damage.
Description
Technical field
The present invention relates to the health food characterized by capsule preparations, especially a kind of fructus lycii extracting flavonoids composition soft capsule and
Preparation method.
Background technique
Flavone compound be fructus lycii in be distributed most wide a kind of compound, have anti-oxidant, coronary artery dilator,
Reduction cholesterolemia and enhancing heart contraction reduce the effects of heartbeat, and have the effect of cough-relieving, flat rapids, eliminating the phlegm.State
Outer research identifies aglucon myricetin, Quercetin and Kaempferol in fructus lycii by hydrolysis.The clear and melodious equal use of Chu
Capillary Electrophoresis-ampere detection method separation identifies the flavones such as 4',5,7-trihydroxyflavone, robinin, luteolin, Kaempferol and Quercetin
Substance.Currently, traditional food and alcohol product are concentrated mainly on for the development and application of fructus lycii, it is more in terms of health food
Using polysaccharides, Boxthorn Seed Oil, carotenoid as functional component study based on, not to the active constituent flavones in fructus lycii
Class is developed.
In consideration of it, the present invention is to a kind of extracting method of the flavones in fructus lycii is provided, with the chromocor extract of acquisition
For functional component, a kind of capsule health food containing is developed by packaging material of capsule, for reducing cholesterolemia, enhancing heart is received
Contracting, prevent aging etc. has adjustment effect.
Summary of the invention
The purpose of the present invention is to provide a kind of fructus lycii flavone powder capsule and preparation method thereof, the Huang extracted from fructus lycii
Ketone extract is embedded in soft capsule, can get more effective health-care effect.
To achieve the goals above, technical solution of the invention are as follows:
A kind of preparation method of fructus lycii flavone powder capsule, comprising the following steps:
(1) it pre-processes: selecting the mildew and rot grain and imperfect grain removed in raw material dry wolfberry, wash off impurity, the dust on surface,
It is placed in 60-65 DEG C of baking oven after drying and crushes, sieving removes fructus lycii seed, and it is spare to leave and take wolfberry fruit powder.
(2) alcohol extracting: weighing wolfberry fruit powder and pour into extractor, and it is 85% that the volume fraction of 10 times of quality of wolfberry fruit powder is used in water-bath
Alcohol reflux extract 2-3 time, each 1-2 h, combined extract, after being concentrated into no alcohol taste, 3 times of concentrate quality of body of addition
Fraction is that 95% ethyl alcohol stands 8-12h, filters and solution is concentrated into no alcohol taste.
(3) it extracts, be concentrated: by solution that step (2) is concentrated to get in proportion being that 1:2-1:4 extract with petroleum ether
2-3 times, petroleum ether layer is discarded, fructus lycii flavones crude extract is obtained, and concentrate it to sticky paste, obtains Flavonoid extract.
(4) ingredient: weighing a certain amount of Flavonoid extract and be dissolved in the safflower seed oil of 1-1.5 times of quality, and stirring makes it sufficiently
It mixes, three times by colloid mill grinding, vacuum outgas steeps to obtain flavones oil.
(5) colloidal sol: weighing gelatin, glycerol, water and curcumin in proportion, first makes it sufficiently with a part of water soaking gelatin
Swelling obtains gelatin solution；Remaining water, glycerol and gelatin solution are mixed, is placed in glue pot and is heated to 65-75 DEG C, stirring makes it
Melting 1-1.5h completely；Curcumin is added, stirring is uniformly mixed it, lets cool, and 60 DEG C of standings are kept, the foam of floating is removed,
Filtering, obtains glue.
(6) pelleting: above-mentioned glue is put into incubator, and temperature is maintained at machine between 80-90 DEG C and suppresses film, will be made
Film and flavones oil by rotating capsule machine processed be automatically pressed into soft capsule.
(7) it is formed: forming that the soft capsule being pressed into is dried at 20 DEG C in net machine, the shaping after shaping 4 hours.
(8) it washes ball: washing away capsule surface oil reservoir in soft capsule washing machine with ethyl alcohol, dry up washing lotion.
(9) it picks up ball: the soft capsule after drying manually being picked up into ball or machinery picks up ball, pick up underproof pellet.
(10) it packs: taking the soft capsule inspection of above-mentioned shape qualification, dispensed after indices all qualifications.
Further, during program step (2) alcohol extracting, the vacuum degree of refluxing extraction is 0.50-0.55MPa, temperature
It is 62-65 DEG C.
Further, the concentration process in program step (3) vacuum degree be 0.40-0.49MPa, temperature 65-70
DEG C rotary evaporation in vacuo equipment in carry out.
Further, the viscosity of Flavonoid extract is 40-44mps in program step (3)-1。
Further, in program step (5), gelatin: glycerol: water ratio by weight claims for 1.8-2:0.8-1:1.6-2
Take, curcumin additive amount account for gelatin, glycerol, water gross mass 0.4-0.6%.
Further, the specification of compacting pellet is 250-300mg/ in program step (6), and every general flavone content is
37.5-45.5mg。
Further, it is rotated in capsule machine production process processed automatically in program step (6), controls 35-40 DEG C of pelleting temperature,
Roll mould revolving speed 3-5r/min.
Extraction, the extraction, concentration technology " mild " for the fructus lycii flavones that this programme provides prevent high temperature and pressure from destroying flavones
Bioactivity；On the other hand, oxidation deterioration can be prevented by mixing and being embedded in safflower seed oil in capsule, ensure that containing for flavones
Amount and biochemical stability, can play preferable health-care effect, convenient to take.
Detailed description of the invention
Fig. 1 is fructus lycii flavone powder capsule preparation technology flow chart of the invention.
Specific embodiment
Below with reference to embodiment, the present invention will be further described.
Embodiment 1
(1) preparation of Flavonoid extract:
The mildew and rot grain and unsound grain removed in raw material dry wolfberry is selected, impurity, the dust on surface is washed off, is placed in 60
It is crushed after being dried in DEG C baking oven, sieving removes the fructus lycii seed on sieve, takes the lower wolfberry fruit powder of sieve spare.
It weighs wolfberry fruit powder and pours into extractor, the ethyl alcohol for being 85% with the volume fraction that quality is 10 times of wolfberry fruit powder in water-bath,
Refluxing extraction 3 times in the refluxing extraction tower that vacuum degree is 0.50Mpa, temperature is 62 DEG C, 1 h, combined extract are concentrated every time
To no alcohol taste, the volume fraction for being added 3 times of concentrate quality is that 95% ethyl alcohol stands 8h, filters and solution is concentrated into no alcohol
Taste.
In proportion it is that 1:2 carries out extraction 2 times by the solution being concentrated to get and petroleum ether, discards petroleum ether layer, obtain Chinese holly
Qi flavones crude extract, and be sent in the vacuum rotary evaporator that vacuum degree is 0.40Mpa, temperature is 65 DEG C and be concentrated, flavones
The viscosity of medicinal extract is concentrated into 40mps-1When concentration process terminate.
(2) ingredient:
It weighs a certain amount of Flavonoid extract to be dissolved in etc. in the safflower seed oil of quality, stirring mixes well it, crosses 150 meshes, will
Obtained mixtures of materials, which is placed in colloid mill, to be ground three times, then in vacuum kettle, controls vacuum degree -0.10Mpa or less
With temperature 60 C or so degassing 2 hours, weighing area was kept for 18-25 DEG C of room temperature, RH50% or less.
(3) colloidal sol:
Ratio is that 1.8:0.8:1.6 weighs gelatin: glycerol: 0.4% turmeric of water and gelatin, glycerol and water total amount by weight
Element；After gelatin is first swollen it sufficiently with the immersion of about 80% water, remaining water and glycerol are mixed, sets and is heated to 65 in glue pot
DEG C, gelatin solution is added, stirring makes it melt about 1h completely, and curcumin is added, and stirring is uniformly mixed it, lets cool, and is kept for 60 DEG C
It stands, removes the foam of floating, filter, measure colloid viscosity.
(4) pelleting:
Above-mentioned glue is put into incubator, temperature is maintained between 80-90 DEG C machine and suppresses film, will be made qualified film and
Content medical fluid is pressed into soft capsule by rotating capsule machine processed automatically.In automatic rotation capsule machine production process processed, pelleting temperature is controlled
35 DEG C of degree rolls 3 revs/min of mould revolving speed；Room temperature is controlled at 20-25 DEG C, 40% or less relative air humidity.To compacting pellet into
Performing check, the specification of pellet are 250-300mg/, and every general flavone content is that 37.5-45.5mg can be determined as qualification.
(5) sizing and shaping:
The soft capsule being pressed into is dried at 20 DEG C in net machine and is shaped, after shaping 4 hours, and shaping.
(6) ball is washed:
Capsule surface oil reservoir is washed away in soft capsule washing machine with ethyl alcohol, dries up washing lotion.By the soft capsule after ethanol washing in net machine
Interior drying about 6 hours.
(7) ball is picked up:
Soft capsule after drying is manually picked up into ball or machinery picks up ball, big piller is picked up, different row ball, obvious wire mark ball, leaks ball, is flat
Qualified soft capsule ball is put into the container of clean dried by ball, thin-walled ball, bubble ball etc., is weighed, and should have state outside container
Mark, indicates name of product, weight, lot number, date, after being sealed with stainless steel barrel capping, send intermediate station.
(8) it packs:
Quantitatively sieve ball enters bottle, 100/bottle of loading amount, and opens drying machine and fill in machine automatically.Outer packing is carried out again.
Embodiment 2
(1) preparation of Flavonoid extract:
The mildew and rot grain and unsound grain removed in raw material dry wolfberry is selected, impurity, the dust on surface is washed off, is placed in 65 DEG C of bakings
It is crushed after being dried in case, sieving removes the fructus lycii seed on sieve, takes the lower wolfberry fruit powder of sieve spare.
It weighs wolfberry fruit powder and pours into extractor, the ethyl alcohol for being 85% with 10 times of wolfberry fruit powder quality of volume fraction in water-bath,
Refluxing extraction 2 times in the refluxing extraction tower that vacuum degree is 0.55Mpa, temperature is 65 DEG C, 2 h, combined extract are concentrated into every time
After alcohol taste, the volume fraction for being added 3 times of concentrate quality is that 95% ethyl alcohol stands 12h, filters and solution is concentrated into no alcohol
Taste.
In proportion it is that 1:4 carries out extraction 3 times by the solution being concentrated to get and petroleum ether, discards petroleum ether layer, obtain Chinese holly
Qi flavones crude extract, and be sent in the vacuum rotary evaporator that vacuum degree is 0.49Mpa, temperature is 70 DEG C and be concentrated, flavones
The viscosity of medicinal extract is concentrated into 44mps-1When concentration process terminate.
(2) ingredient:
A certain amount of Flavonoid extract is weighed to be dissolved in the safflower seed oil of 1.5 times of quality, stirring mixes well it, 150 meshes are crossed,
Obtained mixtures of materials is placed in colloid mill and is ground three times, then in vacuum kettle, control vacuum degree -0.10Mpa with
It deaerates 2 hours with 65 DEG C of temperature or so down, weighing area is kept for 18-25 DEG C of room temperature, RH50% or less.
(3) colloidal sol:
Ratio is that 2:1:2 weighs gelatin: glycerol: 0.6% curcumin of water and gelatin, glycerol and water total amount by weight；Gelatin
After being first swollen it sufficiently with the immersion of about 80% water, remaining water and glycerol are mixed, sets and is heated to 75 DEG C in glue pot, is added
Gelatin solution, stirring make it melt about 1.5h completely, and curcumin is added, and stirring is uniformly mixed it, lets cool, and keep 60 DEG C of standings,
The foam to float is removed, filtering measures colloid viscosity.
(4) pelleting:
Above-mentioned glue is put into incubator, temperature is maintained between 80-90 DEG C machine and suppresses film, will be made qualified film and
Content medical fluid is pressed into soft capsule by rotating capsule machine processed automatically.In automatic rotation capsule machine production process processed, pelleting temperature is controlled
35-40 DEG C of degree rolls 5 revs/min of mould revolving speed；Room temperature is controlled at 20-25 DEG C, 40% or less relative air humidity.To compacting pellet
It tests, the specification of pellet is 250-300mg/, and every general flavone content is that 37.5-45.5mg can be determined as qualification.
(5) sizing and shaping:
The soft capsule being pressed into is dried at 20 DEG C in net machine and is shaped, after shaping 4 hours, and shaping.
(6) ball is washed:
Capsule surface oil reservoir is washed away in soft capsule washing machine with ethyl alcohol, dries up washing lotion.By the soft capsule after ethanol washing in net machine
Interior drying about 6 hours.
(7) ball is picked up:
Soft capsule after drying is manually picked up into ball or machinery picks up ball, big piller is picked up, different row ball, obvious wire mark ball, leaks ball, is flat
Qualified soft capsule ball is put into the container of clean dried by ball, thin-walled ball, bubble ball etc., is weighed, and should have state outside container
Mark, indicates name of product, weight, lot number, date, after being sealed with stainless steel barrel capping, send intermediate station.
(8) it packs:
Quantitatively sieve ball enters bottle, 100/bottle of loading amount, and opens drying machine and fill in machine automatically, then carry out outer packing.
Claims (7)
1. a kind of preparation method of fructus lycii flavone powder capsule, comprising the following steps:
(1) it pre-processes: selecting the mildew and rot grain and imperfect grain removed in raw material dry wolfberry, wash off impurity, the dust on surface,
It is placed in 60-65 DEG C of baking oven after drying and crushes, sieving removes fructus lycii seed, and it is spare to leave and take wolfberry fruit powder；
(2) alcohol extracting: weighing wolfberry fruit powder and pour into extractor, the second for being 85% with the volume fraction of 10 times of quality of wolfberry fruit powder in water-bath
Alcohol reflux extracts 2-3 times, each 1-2 h, combined extract, and after being concentrated into no alcohol taste, 3 times of concentrate quality of volume point is added
Number is that 95% ethyl alcohol stands 8-12h, filters and solution is concentrated into no alcohol taste；
(3) it extracts, be concentrated: being in proportion that 1:2-1:4 carries out extraction 2-3 by solution that step (2) is concentrated to get and petroleum ether
It is secondary, petroleum ether layer is discarded, fructus lycii flavones crude extract is obtained, and concentrate it to sticky paste, obtains Flavonoid extract；
(4) ingredient: weighing a certain amount of Flavonoid extract and be dissolved in the safflower seed oil of 1-1.5 times of quality, and stirring mixes well it,
Three times by colloid mill grinding, vacuum outgas steeps to obtain flavones oil；
(5) colloidal sol: weighing gelatin, glycerol, water and curcumin in proportion, is first swollen it sufficiently with a part of water soaking gelatin
Obtain gelatin solution；Remaining water, glycerol and gelatin solution are mixed, is placed in glue pot and is heated to 65-75 DEG C, stirring makes it completely
Melt 1-1.5h；Curcumin is added, stirring is uniformly mixed it, lets cool, and 60 DEG C of standings are kept, the foam of floating is removed, are filtered,
Obtain glue；
(6) pelleting: above-mentioned glue is put into incubator, and temperature is maintained at machine between 80-90 DEG C and suppresses film, by manufactured glue
Piece and flavones oil pass through rotation capsule machine processed automatically and are pressed into soft capsule；
(7) it is formed: forming that the soft capsule being pressed into is dried at 20 DEG C in net machine, the shaping after shaping 4 hours；
(8) it washes ball: washing away capsule surface oil reservoir in soft capsule washing machine with ethyl alcohol, dry up washing lotion；
(9) it picks up ball: the soft capsule after drying manually being picked up into ball or machinery picks up ball, pick up underproof pellet；
(10) it packs: taking the soft capsule inspection of above-mentioned shape qualification, dispensed after indices all qualifications.
2. a kind of preparation method of fructus lycii flavone powder capsule as described in claim 1, it is characterised in that step (2) alcohol extracting process
In, the vacuum degree of refluxing extraction is 0.50-0.55Mpa, temperature is 62-65 DEG C.
3. a kind of preparation method of fructus lycii flavone powder capsule as described in claim 1, it is characterised in that the concentration in step (3)
Process carries out in the rotary evaporation in vacuo equipment that vacuum degree is 0.40-0.49Mpa, temperature is 65-70 DEG C.
4. a kind of preparation method of fructus lycii flavone powder capsule as described in claim 1, it is characterised in that flavones soaks in step (3)
The viscosity of cream is 40-44mps-1。
5. a kind of preparation method of fructus lycii flavone powder capsule as described in claim 1, it is characterised in that in step (5), gelatin:
Glycerol: water ratio by weight weighs for 1.8-2:0.8-1:1.6-2, and curcumin additive amount accounts for gelatin, glycerol, water gross mass
0.4-0.6%。
6. a kind of preparation method of fructus lycii flavone powder capsule as described in claim 1, it is characterised in that suppress ball in step (6)
The specification of grain is 250-300mg/, and every general flavone content is 37.5-45.5mg.
7. a kind of preparation method of fructus lycii flavone powder capsule as described in claim 1, it is characterised in that step is revolved automatically in (6)
In transformation of ownership capsule machine production process, 35-40 DEG C of pelleting temperature is controlled, rolls mould revolving speed 3-5r/min.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000208A (en) * | 2010-11-09 | 2011-04-06 | 中国科学院西北高原生物研究所 | Method for extracting and preparing medlar leaf flavone |
| CN103006899A (en) * | 2012-12-02 | 2013-04-03 | 陕西方舟制药有限公司 | Medlar general flavones extracting and purifying technology and medlar general flavone detecting method as well as applications of medlar general flavone |
| CN103005449A (en) * | 2013-01-14 | 2013-04-03 | 王跃进 | Medlar soft capsule enriched nutriment |
-
2019
- 2019-03-28 CN CN201910245730.0A patent/CN109998105A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000208A (en) * | 2010-11-09 | 2011-04-06 | 中国科学院西北高原生物研究所 | Method for extracting and preparing medlar leaf flavone |
| CN103006899A (en) * | 2012-12-02 | 2013-04-03 | 陕西方舟制药有限公司 | Medlar general flavones extracting and purifying technology and medlar general flavone detecting method as well as applications of medlar general flavone |
| CN103005449A (en) * | 2013-01-14 | 2013-04-03 | 王跃进 | Medlar soft capsule enriched nutriment |
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