CN101380049B - Black tea extract rich in statins and preparation technique and use thereof - Google Patents
Black tea extract rich in statins and preparation technique and use thereof Download PDFInfo
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a black tea extract which is rich in statins compounds and the preparation technology and usages thereof. The black tea extract comprises the following main chemical constituents: 10-80 percent of the statins compounds and the balance tea polyphenol, theophyline and tea pigment in terms of dry basis or dry matter content; the physical form can be slime, paste, granula, powder and block. The preparing techniques include the following steps: the black tea is ground, the solution is ultrasonically extracted and centrifugalized, thus the extracted solution and tea residue are obtained; the extracted solution can be obtained by concentration and dryness. The black tea extract preparation technology provide a novel way for the tea deep processing and has the advantages of high added value, extensive application of products, easy obtaining of the crude materials, easy and rapid technology and high production efficiency, etc.
Description
Technical field
The present invention relates to a kind of black tea extract and preparation technology and purposes that is rich in statins, is from black tea, to extract statin compound, is used to prepare tablet, capsule, oral liquid as healthy food, functional food, health food and medicine.
Background technology
Tea is one of the world's three big beverages (tea, cocoa, coffee), the model that function such as that tea integrates is medicinal, drink, view and admire, static stability is human material progress highly to be combined with spiritual civilization.Black tea is traditional large teas of China; Mainly contain with Fu brick and black brick be the black tea in Hunan of representative, with the blue bricks be representative the black tea in Hubei, be the black tea in Yunnan, river of representative, be the black tea (tea science 2006 in osmanthus, Yunnan of representative with Pu'er tea and six fort tea with health brick and Fang Bao; 26 (3): 159); China Dark Tea stub NW China, western border areas are called " limit tea " usually in history, and 1,000 for many years drink for the western numerous residents of China always in a large number; In the area of fleshiness food, few vegetables, black tea is proved by long-term practice the importance of health of people.In modern times, the defatting beauty that had of black tea with the antilipoid compound, prevent that the effect of angiocardiopathy also causes people's attention day by day.It is generally acknowledged; Quality style that black tea is exclusive and physiological action are because it has passed through special wet heap manufacturing procedure; The variation different with other teas taken place in chemical composition, and this has significantly shown on the organoleptic feature, but a lot of (the Guangdong chemical industry that on chemical theory, still leaves a question open; 2007,6:126).
3 years Taiwan's scholars Hwang etc. have reported and in Pu'er tea, have found to have statin substance (ACS Symp.2003; 859:87); Measure subsequently and show that Lovastatin is a statin substance unique in the Pu'er tea; Use content that ethyl acetate extraction measures as 139ug/kg (J Chromatogr A, 2006,1119:277).Beijing Xie Chunsheng etc. reported and from Pu'er tea, have detected statin substance in 2006, content be 61.8～260.1mg/kg (Hebei medical science, 2006,12:1362).Our mensuration result shows that the content difference of Lovastatin in the black tea of different productive years, different brackets, different grown places is bigger, and high-load can reach more than 2%.
Statin substance is one type of tissue selectivity HMG CoA (HMG-CoA) reductase inhibitor; Can suppress the biosynthesis of cholesterol competitively; Causing the cell inner cholesterol reduces; The vigor of feedback regulation cell surface low-density lipoprotein (LDL) acceptor promotes that the LDL-C level descends in the blood plasma.Along with growth in the living standard and population astogeny, the cardiovascular and cerebrovascular disease incidence of disease rises year by year, and cardiovascular and cerebrovascular disease is because of due to the dyslipidemia mostly.At present be used for treating the medicine of high fat of blood clinically, statins because of its good effect, safe and reliable, characteristics such as can take for a long time, uses the most extensively, globally formed nearly 40,000,000,000 dollars market, potential market can reach 70,000,000,000 dollars.Statin compound has a little less than the polarity, is insoluble in water, is dissolved in lower alcohol, acetone, ethyl acetate, butyl acetates such as methyl alcohol, ethanol, is insoluble to benzinum, normal hexane.
Pu'er tea paste in patent of invention " a kind of preparation method of novel Pu'er tea paste (Ye Jingchang; Chen Chaoyin: 200810058102.3) " is to utilize warm water ultrasonic extraction and squeezing, cryogenic vacuum to concentrate the Pu'er tea paste that obtains low-temperature extraction, and the tea grounds of then low-temperature extraction being crossed and tea cake are through hot water high temperature extraction squeezing and concentrate and obtain the Pu'er tea paste that high temperature extracts." Pu'er tea and application thereof (Gong Jiashun, Zhou Hongjie., 200510010871.2) " Pu'er tea in the patent of invention is water-soluble, is insoluble to ethanol, methyl alcohol, and chloroform; Main chemical constituent with butt or dry rate count tea polysaccharide 15%～45%, theabrownin class 50%～70%, protein 4.7%～14.0%, all the other be minute quantity tealeaves self material such as congo red is plain, theaflavin and water soluble pectin etc.Patent of invention " a kind of technology of from Pu'er tea, extracting statin compound and products thereof (Xie Chunsheng; thank to the bosom friend; 200610165193.1) " be utilize Pu'er fannings zymotic fluid as raw material through centrifugal filtrating, the tea grounds of obtaining; Filtrating is adsorbed, is obtained eluent with 70% ethanol elution through the macroporous absorbent resin post, and tea grounds obtains leaching liquor through the acetone lixiviate, merges eluent and leaching liquor final vacuum and concentrates; After adding butyl acetate dissolving, through washing, decompression distillation, concentrate, promptly obtain statin compound after leaving standstill crystallization.
Summary of the invention
The purpose of this invention is to provide a kind of black tea extract that is rich in statins; The preparation technology of this black tea extract also is provided; Also have a purpose to provide the purposes of this black tea extract; This technology has been opened up a new way for black tea deep processing and utilization thereof, has that added value of product height, applied range, raw material are easy to get, characteristics such as technology is simple fast, productive rate height.
The objective of the invention is to realize like this: the main chemical constituent of this black tea extract that is rich in statins with butt or dry rate count statin compound 10%～80%, all the other are Tea Polyphenols, theophylline and Tea Pigment, its physical aspect comprises sposh shape, paste, graininess, powdery, bulk.
This preparation technology who is rich in the black tea extract of statins is to be raw material with the black tea that is rich in statin compound, and technical process comprises that pulverizing, solvent extraction, centrifugation obtain extract and tea grounds, extract concentrate, are drying to obtain the black tea extract that is rich in statins through decompression distillation.
This preparation technology who is rich in the black tea extract of statins, described extraction mode comprises cable-styled extraction, counter-current extraction, ultrasonic extraction and refluxing extraction.
This preparation technology who is rich in the black tea extract of statins; The black tea bag of described raw material is drawn together with Pu'er tea and six fort tea and is the black tea in osmanthus, Yunnan of representative, is limit, the Sichuan tea of representative with health brick and Fang Bao; With Fu brick and black brick be the black tea in Hunan of representative, with the blue bricks be representative the black tea in Hubei etc. all adopt pile-fermentations more than 24 hours or the black tea of ageing more than 1 year; Its form comprises pressed tea, loose tea, fannings, tea stalk, tea powder; In addition, the tea dust that obtains during the refining tealeaves of screening and water are carried black tea ointment and water and are carried and deceive tea instant tea tea grounds afterwards and also can be used as raw material of the present invention.In the black tea of raw material, the content of statin compound generally should be between 0.1%～5%.
This preparation technology who is rich in the black tea extract of statins, described liquid-solid extraction solvent is methyl alcohol, ethanol, acetone, ethyl acetate, butyl acetate, solid-to-liquid ratio 1:2～20.
Said statins mainly is a Lovastatin.
The extract that statin compound is rich in the present invention's preparation from black tea can be used for preparing food and drink and health food and medicines such as granule, pulvis, tablet, capsule, oral liquid.
The present invention directly uses black tea to be raw material; And with solvent directly extract, centrifugal obtain filtrating; Through concentrate can obtain being rich in statin compound black tea extract, in food, health food and medicine, extensive use is arranged, also can be further as the raw material of his spit of fland medicine of purifying preparation.The present invention with an organic solvent carries out ultrasonic extraction, and the extract that obtains is insoluble in water, is the Pu'er tea paste that is rich in statin compound.Extract of the present invention is for being soluble in organic solvents such as ethanol, methyl alcohol and chloroform; It is the extract that is insoluble in water; Contained compound is also different, by butt or dry rate count Statins 10%～80%, all the other are for Tea Polyphenols, theophylline and a small amount of Tea Pigment etc., for a new way has been opened up in the tealeaves deep processing; Have the added value of product height, purposes is wide, characteristics such as raw material is easy to get, technology is simple fast, productive rate height.
The specific embodiment
Embodiment 1
The ripe tea loose tea of the Pu'er tea 200g that contains Lovastatin 1.2%; Be crushed to more than 40 orders; Add 1000ml methyl alcohol mixing, ultrasonic circulating extraction 30 minutes, centrifugation; Extract concentrates to such an extent that Pu'er tea methyl alcohol extracts medicinal extract 20g through vacuum, and Lovastatin content 10.6%, surplus are Tea Polyphenols, theophylline, pigment and water.
Embodiment 2
The old tea 200g of Pu'er tea seven sub-cakes that contains Lovastatin 1.3%; Be crushed to more than 40 orders; Add 95% ethanol 2000ml mixing, refluxing extraction 60 minutes, centrifugation; Extract through vacuum concentrate the about 20g of Pu'er tea alcohol extract medicinal extract, Lovastatin content 10.2%, surplus are Tea Polyphenols, theophylline, pigment and water.
Embodiment 3
Six fort tea 400g (containing Lovastatin more than 0.1%); Be crushed to more than 40 orders; Carry out cable-styled extracting with 10 times of amount acetone, extract concentrates and the dry six fort tea acetone extract 42g of getting through vacuum, and Lovastatin content 4.3%, surplus are Tea Polyphenols, theophylline, pigment and water.
Embodiment 4
Contain Lovastatin 2% above Pu'er tea tea dust 300g, carry out cable-styled extracting with ethyl acetate, extract through vacuum concentrate, crystallisation by cooling and dry Pu'er tea ethyl acetate extract 15g, Lovastatin content 36%, surplus are Tea Polyphenols, theophylline, pigment.
Embodiment 5
Water is carried the tea grounds 500g behind the ripe tea extraction of Pu'er tea; Add the 1000ml butyl acetate and carry out ultrasonic extraction; The centrifuging and taking ester concentrates, cools off and separate out crystallization and the dry Pu'er tea butyl acetate extract 5g of getting through 45 ℃ of vacuum mutually, and Lovastatin content 80%, surplus are Tea Polyphenols, theophylline, pigment.
Claims (4)
1. preparation technology who is rich in the black tea extract of statins; It is characterized in that: its main chemical constituent of black tea extract with butt or dry rate count statin compound 10%～80%, all the other are Tea Polyphenols, theophylline and Tea Pigment, its physical aspect comprises sposh shape, paste, graininess, powdery, bulk;
The extraction concrete steps are: with the black tea that is rich in statin compound is raw material, and technical process comprises that pulverizing, solvent extraction, centrifugation obtain extract and tea grounds, and extract concentrates, is drying to obtain the black tea extract that is rich in statins through decompression distillation;
The black tea of said raw material is the black tea in osmanthus, Yunnan, limit, Sichuan tea, the black tea of black tea in Hunan or Hubei; All black tea adopt pile-fermentations more than 24 hours or ageing more than a year; Its form is that the tea dust that obtains when refining of pressed tea, loose tea, fannings, tea stalk, tea powder and screening and water are carried black tea ointment and water and carried the tea grounds after the black instant tea, the content 0.1%～5% of statin compound.
2. the described preparation technology who is rich in the black tea extract of statins of root a tree name claim 1, it is characterized in that: described extraction mode comprises cable-styled extraction, counter-current extraction, ultrasonic extraction and refluxing extraction.
3. the described preparation technology who is rich in the black tea extract of statins of root a tree name claim 1, it is characterized in that: described liquid-solid extraction solvent is methyl alcohol, ethanol, acetone, ethyl acetate, butyl acetate.
4. use and be used to prepare pulvis, granule, tablet, capsule, oral liquid as food and drink, health food and medicine with the said black tea extract that is rich in statins of claim 1.
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| CN102086183B (en) * | 2009-12-04 | 2014-04-16 | 北大方正集团有限公司 | Method for extracting and separating statins substance |
| CN104774691A (en) * | 2015-02-12 | 2015-07-15 | 云南中烟工业有限责任公司 | Perfume originated from Pu'er tea and application of same in flavor enhancement and harm reduction of tobacco products |
| CN104738252A (en) * | 2015-03-07 | 2015-07-01 | 西安康坊食品有限公司 | Method for preparing instant tea from fu brick tea |
| CN107361398A (en) * | 2017-06-26 | 2017-11-21 | 河南中烟工业有限责任公司 | A kind of tea extraction in May and preparation method thereof and the application in cigarette |
| CN110887713A (en) * | 2019-12-04 | 2020-03-17 | 湖南农业大学 | Dark tea brown reference substance and application thereof |
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| CN1973875A (en) * | 2006-12-14 | 2007-06-06 | 谢春生 | Process of extracting Tatine compounds from Puer tea and the product |
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| CN1973875A (en) * | 2006-12-14 | 2007-06-06 | 谢春生 | Process of extracting Tatine compounds from Puer tea and the product |
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| Title |
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| 谢春生等.普洱茶中降血脂的有效成分他汀类化合物的新发现.《河北医学》.2006,(第12期), * |
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