CN109990964A - Fretting damage simulation system in a kind of nerve electrode body - Google Patents
Fretting damage simulation system in a kind of nerve electrode body Download PDFInfo
- Publication number
- CN109990964A CN109990964A CN201910208097.8A CN201910208097A CN109990964A CN 109990964 A CN109990964 A CN 109990964A CN 201910208097 A CN201910208097 A CN 201910208097A CN 109990964 A CN109990964 A CN 109990964A
- Authority
- CN
- China
- Prior art keywords
- nerve electrode
- execution module
- lifting platform
- electrode body
- simulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
- G01D21/00—Measuring or testing not otherwise provided for
- G01D21/02—Measuring two or more variables by means not covered by a single other subclass
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G01M7/00—Vibration-testing of structures; Shock-testing of structures
- G01M7/02—Vibration-testing by means of a shake table
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G01M7/00—Vibration-testing of structures; Shock-testing of structures
- G01M7/02—Vibration-testing by means of a shake table
- G01M7/022—Vibration control arrangements, e.g. for generating random vibrations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G01M7/00—Vibration-testing of structures; Shock-testing of structures
- G01M7/02—Vibration-testing by means of a shake table
- G01M7/025—Measuring arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G01M7/00—Vibration-testing of structures; Shock-testing of structures
- G01M7/02—Vibration-testing by means of a shake table
- G01M7/027—Specimen mounting arrangements, e.g. table head adapters
Abstract
The invention discloses fretting damage simulation systems in a kind of nerve electrode body, are related to medical instrument testing field, including fretting simulation part and vivo environment analog portion；Fretting simulation part includes control drive module and execution module；Controlling drive module includes waveform generator and piezo controller, and waveform generator is connected with piezo controller；Execution module includes lifting platform, L shape conversion tool, piezoelectric ceramics brake, electrode holder and nerve electrode；Lifting platform top plate is arranged on execution module top plate, and one end of L shape conversion tool is connect with lifting platform bottom plate；Piezoelectric ceramics brake is cylinder, and the other end of L shape conversion tool is arranged in；One end of piezoelectric ceramics brake is arranged in electrode holder, and one end of nerve electrode is arranged on electrode holder.The invention can accurate analog neuron electrode et al. Ke environment, the fretting damage of electrode in vivo is included in assessment scope, compared with Bioexperiment, experimental period is short and at low cost.
Description
Technical field
The present invention relates to fretting damage simulation systems in medical instrument testing field more particularly to a kind of nerve electrode body.
Background technique
Neuscience and neural requirement of engineering carry out quantitative study to the electrical activity situation of brain neuroblastoma member, big to understand
The mechanism of brain generation, transmission and processing information.Embedded nerve electrode can recorde nervous system as a kind of senser element
Electrical activity situation.By nerve electrode, electro photoluminescence can also be applied to brain specific region or peripheral nerve, inhibited abnormal
Nerve signal can also be restored by functional electrostimulation for treating the diseases such as Parkinson's disease or other chronic aches
The movement of paralyzed limbs.Since in nerve electrode implantation patient, service life is vital parameter.If the electrode longevity
It orders too short, needs to be performed a plurality of times surgical operation and be implanted into new electrode again, can greatly aggravate the difficulty and cost for the treatment of in this way,
It will increase the pain of sufferer.For decades, scientific research personnel is seeking always the mind that design performance is more excellent, the service life is longer
Through electrode, however this work also encounters very big challenge, because the premise that the nerve electrode service life is quantitatively evaluated is building
One is implanted into the consistent Evaluation Environment of environment high with practical, and realizes that this test environment is very difficult.It is domestic at present
The method in outer assessment nerve electrode service life is divided into experiment in vivo and two kinds of experiment in vitro.
Experiment in vivo is by internal, the service life of recording electrode, such as Barrese of electrode implantation experiment animal to be assessed
Et al. with regard to use such method assessed.The greatest problem of this method is that at high cost, experimental period is long, and experiment is dynamic in addition
Had differences between object with other accidentalia, therefore this method is not found broad application.Experiment in vitro impregnates electrode
In imitated biological tissue's solution, a more severe experimental situation is generated by the method for heating, applying ultrasonic activation,
To assess the durability of nerve electrode, assessed as Takmakov et al. just uses such method.Compared to internal reality
It tests, the test condition of experiment in vitro is easier to realize, but the Evaluation Environment of its application and the environment in true biological tissue
It is far apart.More in recent years documents point out that the actual life after electrode is implanted into vivo and assessment test obtained expection
Service life is not consistent, because the fretting damage of nerve electrode in vivo is not included in assessment scope by this kind of appraisal procedure.Aaron
Gilletti et al. is pointed out, due to beat pulse and respiration, cerebral tissue can generate a few micrometers of amplitude of periodical fine motion.
According to the conclusion of Ma Yakun et al.: about 10 microns of the amplitude of fine motion, about 4 hertz of frequency.Tissue fine motion can make nerve electrode and big
Micron-sized relative motion is constantly generated between cerebral cortex, according to current clinical research experience, this relative motion is
Cause nerve electrode surface that fatigue damage, the one of the major reasons of functional deterioration occurs.Aging of this factor in nerve electrode
It occupies an leading position, cannot ignore in the process.But existing nerve electrode service life evaluation system being capable of not simulated tissue fine motion
Equipment, this is also the maximum reason for causing evaluation method less accurate.
The technical problem to be solved by the present invention is to how accurate analog neuron electrode in vivo micron order movement system, solution
The problem of certainly experimental cost is high, time-consuming and laborious and poor durability.
Therefore, those skilled in the art is dedicated to developing fretting damage simulation system in a kind of nerve electrode body, can essence
The et al. Ke environment of true analog neuron electrode, is included in assessment scope for the fretting damage of electrode in vivo, with Bioexperiment phase
Than experimental period is short and at low cost.
Summary of the invention
In view of the above drawbacks of the prior art, the technical problem to be solved by the present invention is to how accurate analog neuron is electric
The system of pole micron order movement in vivo, solves the problems, such as that experimental cost is high, time-consuming and laborious and poor durability.
To achieve the above object, the present invention provides fretting damage simulation systems in a kind of nerve electrode body, including fine motion
Analog portion and vivo environment analog portion；The fretting simulation part includes control drive module and execution module；The control
Drive module processed includes waveform generator and piezo controller, and the waveform generator is connected with the piezo controller；It is described
Execution module includes execution module top plate, execution module bottom plate, execution module bracket, lifting platform, L shape conversion tool, piezoelectricity pottery
Porcelain brake, electrode holder and nerve electrode；The lifting platform top plate is arranged on the execution module top plate, and the L shape turns
The one end for changing tooling is connect with the lifting platform bottom plate；The piezoelectric ceramics brake is cylinder, and setting is converted in the L shape
The other end of tooling, the piezoelectric ceramics brake are parallel with the execution module bracket；The electrode holder is arranged described
One end of one end of piezoelectric ceramics brake, the nerve electrode is arranged on the electrode holder.
Further, the vivo environment analog portion includes water-bath, simulation brain tissue and simulation celiolymph；It is described
Simulating brain tissue is the silica gel comprising softening agent；The simulation celiolymph is the easy mixing with deionized water of phosphate-buffered salt
Solution.
Further, the simulation brain tissue is arranged on the execution module bottom plate, the other end of the nerve electrode
It is placed in the simulation brain tissue.
Further, the lifting platform top plate is removably disposed on the execution module top plate.
Further, the lifting platform top plate and the execution module top plate are to be bolted.
Further, one end of the L shape conversion tool and the lifting platform bottom plate are to be detachably connected.
Further, one end of the L shape conversion tool and the lifting platform bottom plate are to be bolted.
Further, the piezoelectric ceramics brake is removably disposed in the L shape conversion tool.
Further, the other end of the L shape conversion tool is provided with brake transfer hole, the piezoelectric ceramics brake
It can be inserted into the brake transfer hole.
Further, the lifting platform includes fine motion nut and braking organ, the fine motion nut and the braking organ
One end be in contact.
The present invention can accurate analog neuron electrode et al. Ke environment, the fretting damage of electrode in vivo is included in assessment
Scope, compared with Bioexperiment, experimental period is short and at low cost.
It is described further below with reference to technical effect of the attached drawing to design of the invention, specific structure and generation, with
It is fully understood from the purpose of the present invention, feature and effect.
Detailed description of the invention
Fig. 1 is fretting damage simulation system schematic diagram in the nerve electrode body of a preferred embodiment of the invention；
Fig. 2 is the execution module structural schematic diagram of fretting damage simulation system in nerve electrode body；
Fig. 3 is the lifting platform structural schematic diagram of fretting damage simulation system in nerve electrode body；
Fig. 4 is the braking lifting platform organ structural schematic diagram of fretting damage simulation system in nerve electrode body；
Fig. 5 is the L shape conversion tool structural schematic diagram of fretting damage simulation system in nerve electrode body；
Wherein, 1- nerve electrode, 2- execution module bottom plate, 3- simulation brain tissue, 4- electrode holder, 5-L shape conversion tool,
6- piezoelectric ceramics brake, 7- lifting platform, 8- execution module bracket, 9- execution module top plate, 10- lifting platform top plate, 11- lifting
Platform roof hole, 12- fine motion nut, 13- lifting platform bottom plate, 14- lifting platform bottom plate hole, 15- brake organ, and 16- conversion tool is solid
Determine hole, 17- fixing bolt, 18- fixation hole, 19- brake transfer hole.
Specific embodiment
Multiple preferred embodiments of the invention are introduced below with reference to Figure of description, keep its technology contents more clear and just
In understanding.The present invention can be emerged from by many various forms of embodiments, and protection scope of the present invention not only limits
The embodiment that Yu Wenzhong is mentioned.
In the accompanying drawings, the identical component of structure is indicated with same numbers label, everywhere the similar component of structure or function with
Like numeral label indicates.The size and thickness of each component shown in the drawings are to be arbitrarily shown, and there is no limit by the present invention
The size and thickness of each component.Apparent in order to make to illustrate, some places suitably exaggerate the thickness of component in attached drawing.
As shown in Figure 1, fretting damage simulation system includes fretting simulation part and vivo environment simulation in nerve electrode body
Part.Vivo environment analog portion includes thermostat water bath, simulation brain tissue 3 and simulation spinal fluid.Thermostat water bath is for adjusting
Analog temperature is saved, simulation brain tissue 3 is the silica gel comprising softening agent, is placed in the rectangular channel of execution module bottom plate 2.Fretting simulation
Part includes control drive module and execution module.Controlling drive module includes waveform generator and piezo controller.Execute mould
Block includes lifting platform 7, L shape conversion tool 5, piezoelectric ceramics brake 6, electrode holder 4 and nerve electrode 1.
As shown in Fig. 2, lifting platform top plate 10 is fixed across lifting platform roof hole 11 by bolt in execution module structure
On execution module top plate 9, the elemental height of nerve electrode 1 is adjusted by rotary fine adjustment nut 12；L shape conversion tool 5 passes through
Bolt passes through lifting platform bottom plate hole 14 and is fixed on lifting platform bottom plate 13, and piezoelectric ceramics brake 6 is transferred across L shape conversion tool
Hole 19, piezoelectric ceramics brake 6 are parallel with execution module bracket 8；Electrode holder 4 is connected through a screw thread and piezoelectric ceramics brake
6 displacement end face connects, it can be achieved that vertical direction fine motion；Nerve electrode 1 is bonded on electrode holder 4 by adhesive of medical.
As shown in Figure 3 and Figure 4, it is provided with braking organ 15 between lifting platform top plate 10 and lifting platform bottom plate 13, passes through rotation
Turning fine motion nut 12 can control the height braked between the adjusting lifting platform top plate 10 of organ 15 and lifting platform bottom plate 13.
As shown in figure 5, the side of the brake transfer hole 19 of L shape conversion tool 5 is provided with fixation hole 18 and fixing bolt
17, fixing bolt 17 passes through fixation hole 18, can fix piezoelectric ceramics brake 10.
The following are specific embodiments of the present invention:
Embodiment 1
Formula of the experimental situation temperature to microelectronic component aging acceleration:
t37=tT×2(T-37)/10
Wherein: t37It is simulation in the ageing time (i.e. under 37 DEG C of environment) under body temperature environment, T is actual experimental situation
Temperature, yTFor the duration of senile experiment.Nerve electrode 1 is bonded on electrode holder 4 using adhesive of medical, fine tuning rises
Drop platform 7 makes in the insertion simulation brain tissue 3 of nerve electrode 1.Waveform generator can produce the signal of any amplitude, frequency, phase
Waveform.Signal waveform is applied on piezoelectric ceramics brake 6 after piezo controller enhanced processing, makes its band moving electrode
Fixture 4 generates fine motion, to make the fine motion opposite with the simulation generation vertical direction of brain tissue 3 of nerve electrode 1, analog neuron and brain
Oligodynamics between tissue.Execution module is soaked in simulation cerebrospinal fluid, is added by water bath heating by cerebrospinal fluid is simulated
Heat adjusts waveform generator and piezo controller, so that nerve electrode 1 is generated amplitude 10 micro- to 67 DEG C (practical body temperature is 37 DEG C)
Rice, the vertical fine motion that frequency is 32 hertz (actual tissue vibration frequency is 4 hertz) form the ageing environment of 8 speeds, continue 24
The senile experiment of hour, it can aging in the nerve electrode body that more accurate simulation continues 192 hours.
Embodiment 2
Nerve electrode 1 is bonded on electrode holder 4 using adhesive of medical, fine tuning lifting platform 7 is inserted into nerve electrode 1
It simulates in brain tissue.Waveform generator can produce the signal waveform of any amplitude, frequency, phase.Signal is passing through voltage control
It after device enhanced processing processed, is applied on piezoelectric ceramics brake 6, makes it that electrode holder 4 be driven to generate fine motion, to make neuroelectricity
The fine motion opposite with the simulation generation vertical direction of brain tissue 3 of pole 1, the oligodynamics between analog neuron and cerebral tissue.It will execute
Module is placed on vibration isolation experiment porch, accesses precision mechanics measuring device in the tail end of piezoelectric ceramics brake 6.Mould will be executed
Block is immersed in simulation cerebrospinal fluid, is heated to 37 DEG C for cerebrospinal fluid is simulated using thermostat water bath, is adjusted waveform generator and pressure
Electric controller makes the vertical fine motion that nerve electrode 1 generates 10 microns of amplitude, frequency is 4 hertz.It is surveyed by reading in precision mechanics
Device is measured, the mechanical function between tissue after the implantation of nerve electrode 1 is assessed, thus for optimization 1 dimensional structure of nerve electrode
Active force between surface topography, reduction electrode and tissue provides reference.
Embodiment 3
The electrode of new type nerve currently, the novel degradables material such as hydrogel, fibroin, PLGA has been widely used
In design.It is limited by the limitation of Bioexperiment, degradation material degradation speed in vivo and degradation process are difficult to observe.?
1 surface of nerve electrode one layer of PLGA coating is smeared by the method for 3D printing.Nerve electrode 1 is bonded in using adhesive of medical
On electrode holder 4, fine tuning lifting platform 7 makes in the insertion simulation brain tissue 7 of nerve electrode 1.Waveform generator can produce any width
Value, frequency, the signal waveform of phase.Signal is applied to piezoelectric ceramics brake 6 after piezo controller enhanced processing
On, make it that electrode holder 4 be driven to generate fine motion, to keep nerve electrode 1 and the simulation generation vertical direction of brain tissue 3 opposite micro-
It is dynamic, the oligodynamics between the electrode and cerebral tissue of analog neuron.Execution module is immersed in simulation cerebrospinal fluid, water is passed through
Bath heating is heated to 37 DEG C for cerebrospinal fluid is simulated, and adjusts waveform generator and piezo controller, nerve electrode 1 is made to generate amplitude
The vertical fine motion for being 4 hertz for 10 microns, frequency.By the variation of electrode surface pattern after optical microscopy record implantation, comment
The degradation speed of the novel degradables such as PLGA material after the implantation is estimated, to be development and Application in the electrode novel degradable of nerve
Material provides reference.
The preferred embodiment of the present invention has been described in detail above.It should be appreciated that the ordinary skill of this field is without wound
The property made labour, which according to the present invention can conceive, makes many modifications and variations.Therefore, all technician in the art
Pass through the available technology of logical analysis, reasoning, or a limited experiment on the basis of existing technology under this invention's idea
Scheme, all should be within the scope of protection determined by the claims.
Claims (10)
1. fretting damage simulation system in a kind of nerve electrode body, which is characterized in that including fretting simulation part and vivo environment
Analog portion；The fretting simulation part includes control drive module and execution module；The control drive module includes waveform
Generator and piezo controller, the waveform generator are connected with the piezo controller；The execution module includes executing mould
Block top plate, execution module bottom plate, execution module bracket, lifting platform, L shape conversion tool, piezoelectric ceramics brake, electrode holder and
Nerve electrode；The lifting platform top plate is arranged on the execution module top plate, one end of the L shape conversion tool and the liter
The connection of platform bottom plate is dropped；The piezoelectric ceramics brake is cylinder, and the other end of the L shape conversion tool, the pressure is arranged in
Electroceramics brake is parallel with the execution module bracket；The one of the piezoelectric ceramics brake is arranged in the electrode holder
The one end at end, the nerve electrode is arranged on the electrode holder.
2. fretting damage simulation system in nerve electrode body as described in claim 1, which is characterized in that the vivo environment mould
Quasi- part includes water-bath, simulation brain tissue and simulation celiolymph；The simulation brain tissue is the silica gel comprising softening agent；Institute
Stating simulation celiolymph is the easy mixed solution with deionized water of phosphate-buffered salt.
3. fretting damage simulation system in nerve electrode body as claimed in claim 2, which is characterized in that the simulation brain tissue
It is arranged on the execution module bottom plate, the other end of the nerve electrode is placed in the simulation brain tissue.
4. fretting damage simulation system in nerve electrode body as described in claim 1, which is characterized in that the lifting platform top plate
It is removably disposed on the execution module top plate.
5. fretting damage simulation system in nerve electrode body as claimed in claim 4, which is characterized in that the lifting platform top plate
It is to be bolted with the execution module top plate.
6. fretting damage simulation system in nerve electrode body as described in claim 1, which is characterized in that the L shape converts work
One end of dress is to be detachably connected with the lifting platform bottom plate.
7. fretting damage simulation system in nerve electrode body as claimed in claim 6, which is characterized in that the L shape converts work
One end of dress is to be bolted with the lifting platform bottom plate.
8. fretting damage simulation system in nerve electrode body as described in claim 1, which is characterized in that the piezoelectric ceramics system
Dynamic device is removably disposed in the L shape conversion tool.
9. fretting damage simulation system in nerve electrode body as described in claim 1, which is characterized in that the L shape converts work
The other end of dress is provided with brake transfer hole, and the piezoelectric ceramics brake can be inserted into the brake transfer hole.
10. fretting damage simulation system in nerve electrode body as described in claim 1, which is characterized in that the lifting platform packet
Fine motion nut and braking organ are included, the fine motion nut is in contact with one end of the braking organ.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910208097.8A CN109990964A (en) | 2019-03-19 | 2019-03-19 | Fretting damage simulation system in a kind of nerve electrode body |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910208097.8A CN109990964A (en) | 2019-03-19 | 2019-03-19 | Fretting damage simulation system in a kind of nerve electrode body |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109990964A true CN109990964A (en) | 2019-07-09 |
Family
ID=67129110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910208097.8A Pending CN109990964A (en) | 2019-03-19 | 2019-03-19 | Fretting damage simulation system in a kind of nerve electrode body |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109990964A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112370064A (en) * | 2020-10-28 | 2021-02-19 | 上海交通大学 | Clamping die, auxiliary electrode implantation device utilizing ultrasonic vibration and implantation method |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050021116A1 (en) * | 2003-07-21 | 2005-01-27 | Jiping He | Electrode for implant in live tissue with flexible region to accommodate micro-movement |
| CN102590001A (en) * | 2012-02-24 | 2012-07-18 | 西南交通大学 | Testing method for multi-directional fretting fatigue and testing machine therefor |
| CN102607976A (en) * | 2012-03-12 | 2012-07-25 | 西南交通大学 | Tester and method for testing test environment controllable multi-directional fine motion fatigue |
| KR20130063968A (en) * | 2011-12-07 | 2013-06-17 | 한림대학교 산학협력단 | Micro-drive device for sampling the electical signal of the nerve |
| US8498706B2 (en) * | 2004-11-12 | 2013-07-30 | Pacesetter, Inc. | Capture threshold and lead condition analysis |
| CN103604713A (en) * | 2013-11-21 | 2014-02-26 | 西南交通大学 | Multidirectional fretting wear device and testing method for heat transmission pipe of steam generator |
| CN104799816A (en) * | 2015-04-17 | 2015-07-29 | 上海交通大学 | Evaluation device for implant damage and fretting damage of neural electrode |
| CN109128400A (en) * | 2017-06-16 | 2019-01-04 | 科锐精密工业（深圳）有限公司 | A kind of high frequency fine motion Electrodes fixture |
-
2019
- 2019-03-19 CN CN201910208097.8A patent/CN109990964A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050021116A1 (en) * | 2003-07-21 | 2005-01-27 | Jiping He | Electrode for implant in live tissue with flexible region to accommodate micro-movement |
| US8498706B2 (en) * | 2004-11-12 | 2013-07-30 | Pacesetter, Inc. | Capture threshold and lead condition analysis |
| KR20130063968A (en) * | 2011-12-07 | 2013-06-17 | 한림대학교 산학협력단 | Micro-drive device for sampling the electical signal of the nerve |
| CN102590001A (en) * | 2012-02-24 | 2012-07-18 | 西南交通大学 | Testing method for multi-directional fretting fatigue and testing machine therefor |
| CN102607976A (en) * | 2012-03-12 | 2012-07-25 | 西南交通大学 | Tester and method for testing test environment controllable multi-directional fine motion fatigue |
| CN103604713A (en) * | 2013-11-21 | 2014-02-26 | 西南交通大学 | Multidirectional fretting wear device and testing method for heat transmission pipe of steam generator |
| CN104799816A (en) * | 2015-04-17 | 2015-07-29 | 上海交通大学 | Evaluation device for implant damage and fretting damage of neural electrode |
| CN109128400A (en) * | 2017-06-16 | 2019-01-04 | 科锐精密工业（深圳）有限公司 | A kind of high frequency fine motion Electrodes fixture |
Non-Patent Citations (1)
| Title |
|---|
| W. ZHANG ET.AL: ""Experimental evaluation of neural probe"s insertion induced injury based on digital image correlation method"", 《MEDICAL PHYSICS》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112370064A (en) * | 2020-10-28 | 2021-02-19 | 上海交通大学 | Clamping die, auxiliary electrode implantation device utilizing ultrasonic vibration and implantation method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Bonmassar et al. | Microscopic magnetic stimulation of neural tissue | |
| CN104548390B (en) | It is a kind of to obtain the method and system that the ultrasound emission sequence that cranium focuses on ultrasound is worn for launching | |
| Mercanzini et al. | In vivo electrical impedance spectroscopy of tissue reaction to microelectrode arrays | |
| Lee et al. | Enhanced control of cortical pyramidal neurons with micromagnetic stimulation | |
| Rojas et al. | Acoustic stimulation can induce a selective neural network response mediated by piezoelectric nanoparticles | |
| EP2377572A1 (en) | A bio-hybrid implant for connecting a neural interface with a host nervous system | |
| Pothof et al. | Chronic neural probe for simultaneous recording of single-unit, multi-unit, and local field potential activity from multiple brain sites | |
| EP1464952B1 (en) | Apparatus for stimulating an animal cell and recording its physiological signal and production and use methods thereof | |
| US20150148710A1 (en) | Ultrasound Modulation of the Brain for Treatment of Stroke, Brain Injury, and Other Neurological Disorders | |
| Olson et al. | Closed-loop cortical control of direction using support vector machines | |
| Wang et al. | The use of a double-layer platinum black-conducting polymer coating for improvement of neural recording and mitigation of photoelectric artifact | |
| Muthuswamy et al. | Electrostatic microactuators for precise positioning of neural microelectrodes | |
| Rutten et al. | Neuro-electronic interfacing with multielectrode arrays | |
| Viveros et al. | Advanced one-and two-dimensional mesh designs for injectable electronics | |
| Poppendieck et al. | Development, manufacturing and application of double-sided flexible implantable microelectrodes | |
| Ritaccio et al. | Proceedings of the second international workshop on advances in electrocorticography | |
| CN109990964A (en) | Fretting damage simulation system in a kind of nerve electrode body | |
| Tannan et al. | A portable tactile sensory diagnostic device | |
| Lee et al. | Scalable three-dimensional recording electrodes for probing biological tissues | |
| Sugai et al. | Numerical Analysis of Microcoil‐Induced Electric Fields and Evaluation of In vivo Magnetic Stimulation of the Mouse Brain | |
| Zhang et al. | Carbon multi‐electrode arrays as peripheral nerve interface for neural recording and nerve stimulation | |
| Marino et al. | Nanomaterial-Assisted Acoustic Neural Stimulation | |
| Zhang et al. | Implantable neural electrodes: from preparation optimization to application | |
| Zeveke et al. | An integrative framework of the skin receptors activation: Mechanoreceptors activity patterns versus" labeled lines" | |
| Xu et al. | Noninvasive Electrical Stimulation Basics and Devices |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190709 |