CN104799816A - Evaluation device for implant damage and fretting damage of neural electrode - Google Patents
Evaluation device for implant damage and fretting damage of neural electrode Download PDFInfo
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Abstract
The invention relates to an evaluation device for implant damage and fretting damage of a neural electrode. The evaluation device comprises a control module, a driving module and a post processing module, wherein the control module and the driving module can finish experimental simulation of the implant process and the fretting state of the neutral electrode by setting different fretting frequencies and wave forms as well as selectable implant parameters; the post processing module is used for calculating the size and the range of tissue damage by a microscopical technique and the digital image correlation theory and comparing the size and the range of the tissue damage with a numerical simulation result. By preparing a soft tissue model of which mechanical properties are close to those of brain tissues, the repeatability of experimental results can be guaranteed, and the problem that the histology experiment is intervened by biological factors is avoided. According to the evaluation device, the verification can be provided for the previous finite element numerical simulation results, the research on mutual action of the neutral electrode and the brain tissues is improved to the experimental stage, design reference is provided for a novel low-damage neutral electrode more effectively, and the long-term service life of the neutral electrode is prolonged.
Description
Technical field
The present invention relates to medical apparatus and instruments field tests, specifically relate to the apparatus for evaluating that a kind of nerve electrode implants damage and fretting damage, mainly for assessment of nerve electrode wound to tissue generation under implantation process and fine motion state.
Background technology
Nerve electrode, as the critical component connecting nervous tissue and external equipment, is with a wide range of applications in the clinical practices such as epilepsy, Parkinson disease, spinal cord injury and other nervous system disease auxiliary treatment.At present, due to cerebral tissue autoimmune response, the long term life of nerve electrode is restricted, and this is after acute injury because electrode produces cerebral tissue in implantation process and electrode are implanted and the fretting damage that produces of cerebral tissue Long Term Contact.Namely cerebral tissue immunoreation can cause electrode surface to produce threadiness or cellular tissue parcel after triggering, thus the electric signal transmission between block nerves electrode and neuron.
At present, the Liang Zhong tissue injury produced after implanting for electrode, more existing scholars have carried out evaluation studies, comprise the Rigidity Matching between electrode and cerebral tissue, physical coupling degree, electrode material selection, electrode geometry etc.These researchs generally adopt numerical value emulation method, arranged corresponding boundary condition, load and contact by definition cerebral tissue, computation organization's internal strain field with electrode material.But for a long time, result that this employing Method of Numerical Simulation draws lacks experimental verification, reason is mainly that biological cerebral tissue is difficult to obtain, and be placed in external after have ageing, organization mechanics character easily changes.
Find by prior art documents, in the Effects of insertion conditions on tissue strain and vascular damage during neuroprosthetic device insertion article that Bjornsson etc. write on Journal of neural engineering magazine, measuring has been carried out to the distortion of Different electrodes implantation parameter undertissue.Employ biological tissue's Mus brain in literary composition, be made into the section of 500 micron thickness.By changing different implantation parameters, comprising the key groove of electrode, the speed etc. of implantation, calculating the mean strain of tissue surface area.Obtain the sensitivity of mean strain to given parameters.But find in experimentation, histology's biotic experiment can affect by the biological factor of multiple the unknown and make metaplasia, not easily investigates certain single factors, causes same electrode parameter to draw different experimental results.And means of testing only can for implantation process in literary composition, for cerebral tissue fine motion state, due to amplitude little (~ 25 μm), metaplasia cannot Measurement accuracy.
Obviously, existing nerve electrode damage measure means need to obtain experimental verification on the one hand, need to overcome the biological factor impact of tissue in experiment itself on the other hand.In addition, optimal experiment test system should organize acute injury in evaluate electrode implantation process, can assess again the chronic injury organized under fine motion state.Integrating, mainly there is following difficult point in the design of Novel experimental test macro:
(1) driving applied electrode can carry out the fine motion of micron order small magnitude simultaneously and grade amplitude is implanted;
(2) the detection means spatial resolution used is enough high with the metaplasia caught under implantation process especially fine motion state;
(3) repeatability of experimental result is enough high to guarantee that identical experiment parameter draws consistent experimental result.
Summary of the invention
The present invention is based on and implant damage and the deficiency of fretting damage aspect for assessing nerve electrode at present, provide a kind of nerve electrode of assessing and implant the test macro damaged with fretting damage.Based on loading by means of digital image correlation method and digital micrograph technology, by arranging different fine motion frequencies and waveform, and the implantation parameter that can select, complete the experimental simulation of nerve electrode implantation process and fine motion state.Test macro can calculate tissue injury's size, compensate for numerical simulation result of calculation and can not get verifying and the defect that is easily disturbed of histology experiment, more effectively provides design reference for novel low injured nerve electrode, extends nerve electrode Long Service Life.
Technical solution of the present invention is as follows:
Nerve electrode implants an apparatus for evaluating for damage and fretting damage, and its feature is, is simulated part by implantation and fretting simulation part, soft tissue and is organized strain calculation part to form;
Described implantation and simulation part are made up of control module and driver module;
Described soft tissue simulation part is divided into band artificial nano speckle soft tissue model;
Described strain calculation part of organizing comprises micro imaging system and computer;
Described control module produces the pulse signal of assigned frequency and waveform, makes driver module drive electrode implantation belt artificial nano speckle soft tissue model or back and forth fine motion in band artificial nano speckle soft tissue model; Described micro imaging system carries out imaging to band artificial nano speckle soft tissue model surface, and image is reached computer, computer forms digital speckle sequence by storing each width image, and obtain being organized in the displacement field under electrode implantation or fine motion process and strain field by digital picture related operation, by contrasting with numerical simulation result of calculation, complete the checking of Numerical Simulation Results.
The stepper motor driver that described control module comprises signal generator and is connected with this signal generator.
Described driver module comprises motor, drive mechanism, L-type pedestal, motion platform, fine gasket, electrode base, electrode base screw, neural silicon electrode, organizes pedestal, tissue container and microscope carrier;
Described L-type pedestal is fixed on described microscope carrier, the bottom surface of this L-type pedestal is provided with two guide grooves be parallel to each other, match with the boss of the bottom being arranged on described motion platform, this boss is embedded in L-type pedestal guide groove, motion platform is moved on L-type pedestal, the end face of described motion platform is provided with groove, described electrode base and fine gasket are from top to bottom placed in this groove successively, and be connected by electrode base screw and motion platform, described neural silicon electrode is placed on described electrode base, both are affixed by biomedical glue,
Described pedestal of organizing is fixed on described microscope carrier, and the end face of this tissue pedestal is provided with groove, and described tissue container fixed placement is in groove, and the soft tissue described in placing in this tissue container simulates part.
Motion platform described in described motor drives through described drive mechanism moves on described L-type pedestal.
Drive mechanism comprises master gear, secondary gear, screw shaft, nut, bearing block, key and thrust bearing;
Described master gear and motor are connected, and secondary gear is connected with screw shaft by key, and is located by the shaft shoulder, and nut is fixed;
Described screw shaft one end is connected with thrust bearing, and the other end is passed the metapore of L-type pedestal and connected with motion platform by screw;
Described thrust bearing is placed in the circular groove of bearing block side, and described bearing block is upper and lower dissection type, and with screw fastening; Described bearing block opposite side is fixedly connected with the L shape side of L-type pedestal.
Described band artificial nano speckle soft tissue model sample makes raw material: silicone rubber, softening agent, ethanol, dodecylbenzene sodium sulfonate, graphite powder, molybdenum bisuphide.
Described soft tissue strain calculation part is post-processing module, comprises digit microscope and computer, and described digit microscope is communicated by LAN intersection cable with computer.Described digit microscope carries out imaging to the organize models surface in tissue container in 0.5 second with Fixed Time Interval, and image is reached computer, and computer forms digital speckle sequence by storing each width image.Described computer run digital picture related algorithm obtains being organized in electrode implantation process or fine motion state bottom offset field and strain field.Described computer is also for further processing to strain field, calculates the number of pixels exceeding and specify strain threshold, and is converted into area physical quantity by the calibration coefficient that microscope magnification is corresponding.
Compared with prior art, technique effect of the present invention is as follows:
The present invention realizes nerve electrode implantation process and fine motion state simulation, by preparing homodisperse nano artificial speckle, in conjunction with microtechnique and digital picture correlation theory, can carry out high-acruracy survey to organize models's internal strain field.The Finite Element Numerical Simulation result of study that be can be in the past by this experimental system provides checking, and nerve electrode and the interactional research of cerebral tissue are brought up to the experimental stage.By the soft tissue model that preparation is close with cerebral tissue mechanical property, the repeatability of experimental result can be ensured, avoid the problem that histology experiment is disturbed by biological factor.
The present invention meets the movement needs of implantation process and fine motion state bottom electrode simultaneously; Based on digital picture correlation theory, in conjunction with digital microtechnique, and the soft tissue sample of preparation band artificial nano speckle, meet certainty of measurement requirement; By the repeatability using the organize models similar to soft tissue mechanics character effectively can ensure experimental result.
Accompanying drawing explanation
Fig. 1 is that nerve electrode implants damage and fretting damage apparatus for evaluating systematic survey schematic diagram;
Fig. 2 is that nerve electrode implants damage and driver module structural representation in fretting damage apparatus for evaluating;
Fig. 3 is driver module drive mechanism schematic diagram;
Fig. 4 is electrode and organize models's clamping schematic diagram;
Fig. 5 is organize models's clamping schematic diagram in driver module
In figure: 1-signal generator; 2-stepper motor driver; 3-driver module; 4-micro imaging system; 5-computer; 6-digital speckle sequence; 7a-experimental calculation result; 7b-Numerical Simulation Results; 8-motor; 9-master gear; 10-secondary gear; 11-screw shaft; 12-nut; 13a-top chock; 13b-step; 14-key; 15-thrust bearing; 16-bearing groove; 17-bearing block top screw; 18-bearing block rear end screw; 19-L-type pedestal; 20-soket head cap screw; 21-guide groove; 22-motion platform; 23-fine gasket; 24-electrode base; 25-electrode base screw; 26-neural silicon electrode; 27-organize pedestal; 28-organize pedestal screw; 29-tissue container; 30-band nano artificial speckle organize models; 31-tissue container screw; 32-microscope carrier.
Detailed description of the invention
Below in conjunction with accompanying drawing, embodiments of the invention are elaborated: the present embodiment is implemented under premised on technical solution of the present invention, give concrete implementation method, but protection scope of the present invention is not limited to following embodiment.
Nerve electrode is implanted damage and is specifically implemented as follows with fretting damage apparatus for evaluating:
As Fig. 1, for nerve electrode implants damage and fretting damage apparatus for evaluating systematic survey schematic diagram.Nerve electrode is implanted damage and simulate with fretting simulation part, soft tissue partly with fretting damage evaluating system by implanting and organize strain calculation part to form; Described implantation and simulation part are made up of control module and driver module; Described control module comprises signal generator 1 and stepper motor driver 2; This control module can produce the pulse signal of assigned frequency and waveform, makes driver module 3 drive silicon electrode complete fine motion or implant action; Described driver module 3 drive electrode implants soft tissue model or reciprocal fine motion in soft tissue model; Described post-processing module comprises micro imaging system 4 and computer 5, the 4 pairs of metaplasias of described micro imaging system form digital speckle sequence 6, and by digital picture related operation output organization internal strain field 7a, by contrasting with numerical simulation result of calculation 7b, complete the checking of Numerical Simulation Results.
As Fig. 2, implant damage for nerve electrode and assemble schematic diagram with driver module in fretting damage apparatus for evaluating, described driver module comprises motor 8, master gear 9 and secondary gear 10, screw shaft 11, bearing block 13, thrust bearing 15, L-type pedestal 19, motion platform 22, fine gasket 23, electrode base 24, neural silicon electrode 26, organizes pedestal 27 and tissue container 29.
Fig. 3 is drive mechanism schematic diagram in driver module, and in described primary gear speed reducing mechanism, master gear 9 is connected by D type mouth and motor 8, and reducing gear another gear 10 is connected with screw shaft 11 by key 14, and is located by the shaft shoulder, and nut 12 is fixed; Described screw shaft 11 carries out one end support for using thrust bearing 15, and the other end is passed L-type pedestal 19 metapore and connected with motion platform 22 by electrode base screw 25; Described thrust bearing 15 is placed in bearing block 13 one end bearing groove 16, and described bearing block 13 is upper and lower dissection type, and fastening with bearing block top screw 17; Described bearing block 13 other end and L-type pedestal 19 are connected by the screw 18 be arranged symmetrically with; When receiving stepper motor driver 2 pulse signal, motor 8 rotates an angle, by gear reduction, screw shaft 11 is rotated, due to the effect of screw shaft 11 tail end thrust bearing 15, make its axial freedom restricted, therefore generation moves linearly by motion platform 22.
Fig. 4 is electrode base schematic diagram in driver module, and described L-type pedestal 19 is connected with microscope carrier 32 by soket head cap screw 20, and this base bottom surface is shaped with the guide groove 21 be parallel to each other; Be provided with boss bottom described motion platform 22, this boss is embedded in guide groove 21, can carry out linear reciprocating motion; Described motion platform 22 end face is shaped with groove, has fine gasket 23 and electrode base 24 in groove; Described fine gasket 23 and electrode base 24 are connected by electrode base screw 25 and motion platform 22; Described electrode base 24 is equipped with neural silicon electrode 26, and both are affixed by biomedical glue.
Fig. 5 is organize models's clamping schematic diagram in driver module, and described pedestal 27 and the microscope carrier 32 organized is connected by organizing pedestal screw 28, and this base top surface is shaped with groove, is placed with tissue container 29 in this groove; Described tissue container 29 is built-in with soft tissue simulation part, and described soft tissue simulation part is divided into band artificial nano speckle soft tissue model sample 30, and described tissue container 29 side direction is provided with shrinkage pool, organizing by tissue container screw 31 pedestal 27 is located and is connected.
Described band artificial nano speckle soft tissue model sample 30 makes raw material and is: silicone rubber, softening agent, ethanol, dodecylbenzene sodium sulfonate, graphite powder, molybdenum bisuphide.Described dodecylbenzene sodium sulfonate is a kind of anion surfactant, can promote that graphite powder is evenly distributed on silastic surface to form high-quality nano artificial speckle.Described molybdenum bisuphide adjustable silicone rubber coefficient of friction is to simulate the Frotteurism between silicon electrode and organize models better.Described band artificial nano speckle soft tissue model sample 30, by uniaxial tension compression test, regulates softening agent ratio until mate with cerebral tissue mechanical property.
Described strain calculation part of organizing is post-processing module, comprises digit microscope 4 and computer 5, and described digit microscope 4 is communicated by LAN intersection cable with computer 5.Described digit microscope 4 carries out imaging to band artificial nano speckle soft tissue model 30 surface in tissue container 29 in 0.5 second with Fixed Time Interval, and image is reached computer 5, computer forms digital speckle sequence 6 by storing each width image, and described computer 5 runs following digital picture related algorithm and obtains being organized in electrode implantation process or fine motion state bottom offset field and strain field:
Wherein: f
m, g
mbe respectively digit microscope 4 take reference picture and present image in subset average gray, (x, y) is subset pixel coordinate, and (u, v) is displacement to be solved.When C value in formula more close to 0 time, then represent in present image, search out the subset area the highest with subset area degree of association in reference picture, the displacement of selected coordinate points can be determined in present image thus.
Described computer 5 is also for further processing to strain field 7a, calculates the number of pixels exceeding strain threshold, and described strain threshold is 5%, this be due to when organize strain higher than 5% time have a large amount of Neuronal cell death.Gained number of pixels is also converted into area physical quantity by the calibration coefficient that microscope magnification is corresponding by described computer 5, thus display nerve electrode implants damage and fretting damage scope more intuitively.
Claims (7)
1. nerve electrode implants damage and an apparatus for evaluating for fretting damage, it is characterized in that, is simulated part by implantation and fretting simulation part, soft tissue and is organized strain calculation part to form;
Described implantation and simulation part are made up of control module and driver module;
Described soft tissue simulation part is divided into band artificial nano speckle soft tissue model;
Described strain calculation part of organizing comprises micro imaging system and computer;
Described control module produces the pulse signal of assigned frequency and waveform, makes driver module drive electrode implantation belt artificial nano speckle soft tissue model or back and forth fine motion in band artificial nano speckle soft tissue model; Described micro imaging system carries out imaging to band artificial nano speckle soft tissue model surface, and image is reached computer, computer forms digital speckle sequence by storing each width image, and obtain being organized in the displacement field under electrode implantation or fine motion process and strain field by digital picture related operation, by contrasting with numerical simulation result of calculation, complete the checking of Numerical Simulation Results.
2. nerve electrode according to claim 1 implants damage and fretting damage apparatus for evaluating, it is characterized in that, the stepper motor driver (2) that described control module comprises signal generator (1) and is connected with this signal generator (1).
3. nerve electrode according to claim 1 implants damage and fretting damage apparatus for evaluating, it is characterized in that, described driver module comprises motor (8), drive mechanism, L-type pedestal (19), motion platform (22), fine gasket (23), electrode base (24), electrode base screw (25), neural silicon electrode (26), organizes pedestal (27), tissue container (29) and microscope carrier (32);
Described L-type pedestal is fixed on described microscope carrier, the bottom surface of this L-type pedestal is provided with two guide grooves be parallel to each other, match with the boss of the bottom being arranged on described motion platform, this boss is embedded in L-type pedestal guide groove, motion platform is moved on L-type pedestal, the end face of described motion platform is provided with groove, described electrode base and fine gasket are from top to bottom placed in this groove successively, and be connected by electrode base screw and motion platform, described neural silicon electrode is placed on described electrode base, both are affixed by biomedical glue,
Described pedestal of organizing is fixed on described microscope carrier, and the end face of this tissue pedestal is provided with groove, and described tissue container fixed placement is in groove, and the soft tissue described in placing in this tissue container simulates part.
Motion platform (22) described in described motor (8) drives through described drive mechanism moves on described L-type pedestal.
4. nerve electrode according to claim 3 implants damage and fretting damage apparatus for evaluating, it is characterized in that, described drive mechanism comprises master gear (9), secondary gear (10), screw shaft (11), nut (12), bearing block (13), key (14) and thrust bearing (15);
Described master gear and motor are connected, and secondary gear (10) is connected with screw shaft by key, and is located by the shaft shoulder, and nut is fixed;
Described screw shaft one end is connected with thrust bearing, and the other end is passed the metapore of L-type pedestal and connected with motion platform by screw;
Described thrust bearing is placed in the circular groove of bearing block side, and described bearing block is upper and lower dissection type, and with screw fastening; Described bearing block opposite side is fixedly connected with the L shape side of L-type pedestal.
5. nerve electrode according to claim 1 implants damage and fretting damage apparatus for evaluating, it is characterized in that, described strain calculation part of organizing belongs to post-processing module, comprise digit microscope and computer, described digit microscope carries out imaging to the organize models surface in tissue container in 0.5 second with Fixed Time Interval, and image is reached computer.
6. implant damage and fretting damage apparatus for evaluating according to the arbitrary described nerve electrode of claim 1-4, it is characterized in that, described computer obtains being organized in electrode implantation process or fine motion state bottom offset field and strain field by digital picture related algorithm, and strain field is processed, calculate the number of pixels exceeding and specify strain threshold, and be converted into area physical quantity by the calibration coefficient that microscope magnification is corresponding.
7. implant damage and fretting damage apparatus for evaluating according to the arbitrary described nerve electrode of claim 1-4, it is characterized in that, described band artificial nano speckle soft tissue model sample makes raw material and is: silicone rubber, softening agent, ethanol, dodecylbenzene sodium sulfonate, graphite powder, molybdenum bisuphide.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109990964A (en) * | 2019-03-19 | 2019-07-09 | 上海交通大学 | Fretting damage simulation system in a kind of nerve electrode body |
| CN112834367A (en) * | 2020-12-31 | 2021-05-25 | 中国人民解放军陆军特色医学中心 | Skull collision test system and dynamic measurement method of brain tissue strain |
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Application publication date: 20150729 |