CN109966633A - A kind of transdermal delivery system and its application - Google Patents
A kind of transdermal delivery system and its application Download PDFInfo
- Publication number
- CN109966633A CN109966633A CN201910009561.0A CN201910009561A CN109966633A CN 109966633 A CN109966633 A CN 109966633A CN 201910009561 A CN201910009561 A CN 201910009561A CN 109966633 A CN109966633 A CN 109966633A
- Authority
- CN
- China
- Prior art keywords
- delivery system
- transdermal delivery
- fixed cell
- unit
- administration unit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000037317 transdermal delivery Effects 0.000 title claims abstract description 55
- 239000003814 drug Substances 0.000 claims abstract description 44
- 229940079593 drug Drugs 0.000 claims abstract description 37
- 206010061218 Inflammation Diseases 0.000 claims abstract description 6
- 239000000730 antalgic agent Substances 0.000 claims abstract description 6
- 229940035676 analgesics Drugs 0.000 claims abstract description 4
- 238000010438 heat treatment Methods 0.000 claims description 27
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 239000002552 dosage form Substances 0.000 claims description 6
- 239000006071 cream Substances 0.000 claims description 5
- 229920000049 Carbon (fiber) Polymers 0.000 claims description 3
- 230000003213 activating effect Effects 0.000 claims description 3
- 239000003435 antirheumatic agent Substances 0.000 claims description 3
- 239000004917 carbon fiber Substances 0.000 claims description 3
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 3
- 230000002040 relaxant effect Effects 0.000 claims description 3
- 230000008961 swelling Effects 0.000 claims description 3
- 210000002435 tendon Anatomy 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000011505 plaster Substances 0.000 abstract description 14
- 230000007812 deficiency Effects 0.000 abstract description 7
- 239000002246 antineoplastic agent Substances 0.000 abstract description 5
- 229940041181 antineoplastic drug Drugs 0.000 abstract description 5
- 230000008859 change Effects 0.000 abstract description 3
- 238000007876 drug discovery Methods 0.000 abstract description 2
- 230000001225 therapeutic effect Effects 0.000 description 6
- 206010033372 Pain and discomfort Diseases 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 239000003349 gelling agent Substances 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 210000003423 ankle Anatomy 0.000 description 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 208000035824 paresthesia Diseases 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0625—Warming the body, e.g. hyperthermia treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
Abstract
The invention belongs to Field of Drug Discovery more particularly to a kind of transdermal delivery system and its applications.The present invention provides a kind of transdermal delivery system, the transdermal delivery system includes: fixed cell and administration unit, and the fixed cell is used to the administration unit being fixed on default administering position；The administration unit is detachably connected with the fixed cell.The present invention also provides a kind of application of above-mentioned transdermal delivery system in anti-inflammation drugs, analgesic drug product and anti-tumor drug.In technical solution provided by the invention, administration unit is set in the cavity of fixed cell, is detachably connected with fixed cell, in replacement, only needs to change administration unit, and when dressing there will be no pain, effectively improves comfort level.A kind of transdermal delivery system provided by the invention and its application, solve in the prior art, and comfort level is poor when in use and the technological deficiency for taking pain is torn after for plaster.
Description
Technical field
The invention belongs to Field of Drug Discovery more particularly to a kind of transdermal delivery system and its applications.
Background technique
Patche (plaster) is a traditional ancient technology, has been used and has been used in many a centuries deliver medicine
Object has very ancient long history.Traditional plaster is applied by drug in toughness made of drug and adhesive patches
Plaster made of patch can glue on the skin, carry out the delivering of drug.
However, adhesive plaster patch is on the skin, after use, when tearing peeling, it frequently can lead to skin and hair and fall off,
And can usually cause extremely not accommodating severe pain, after being stained with, it is not suitable for tearing it down immediately.Traditional patch cannot connect
Water is touched, adhesive patches are also easy to cause user's skin allergy.
Therefore, a kind of transdermal delivery system and its application are developed, for solving in the prior art, plaster relaxes when in use
Appropriateness is poor and the technological deficiency for taking pain is torn after, becomes those skilled in the art's urgent problem to be solved.
Summary of the invention
In view of this, the present invention provides a kind of transdermal delivery system and its application, for solving in the prior art, plaster
Comfort level is poor when in use and the technological deficiency for taking pain is torn after.
The present invention provides a kind of transdermal delivery system, the transdermal delivery system includes: fixed cell and administration unit,
The fixed cell is used to the administration unit being fixed on default administering position；
The administration unit is detachably connected with the fixed cell, and the fixed cell is equipped with a cavity, the administration
Unit is set in the cavity.
Preferably, the transdermal delivery system further include: heating unit, the heating unit are described to prescription for heating
Member.
Preferably, the heating unit is infrared ray auxiliary heating element.
Preferably, the temperature of the heating unit is adjustable.
Preferably, the fixed cell is carbon fiber fixed cell.
Preferably, the transdermal delivery system further include: adjust unit, the adjusting unit and the fixed cell connect
It connects, for adjusting the length of the fixed cell.
Preferably, the adjusting unit is an air pump.
Preferably, the dosage form of the administration unit is selected from: in gelling agent, gelatum agent, creams agent, granule and nanometer agent
Any one or more.
Preferably, the fixed cell is scalable fixed cell.
The present invention also provides a kind of including transdermal delivery system described in any of the above one in anti-inflammation drugs, anodyne
Object, anti-tumor drug, relaxing tendons and activating collaterals drug, antirheumatic drug and go application in swelling drug.
From above-mentioned technical proposal, it can be concluded that, a kind of transdermal delivery system provided by the invention and its application have following
Advantage:
1, administration unit and fixed cell are to be detachably connected, and can replace different administrations according to different use requirements
Unit, and, cooperate the different medication stages to adjust dosage, medication unit can take out at any time and replace at any time；
2, in replacement, no replacement is required, and fixed cell is replaced there is no need to remove transdermal delivery system monolith to prescription
When first, pain and discomfort will not be caused.
3, it is additionally provided with heating unit, the heat radiation that heating unit generates aid blood circulation and can accelerate drug release, into
One step improves therapeutic effect.
4, administration unit and fixed cell are to be detachably connected, and can replace different administrations according to different use requirements
Unit, and, cooperate the different medication stages to adjust dosage, medication unit can take out at any time and replace at any time；
5, in replacement, no replacement is required, and fixed cell is replaced there is no need to remove transdermal delivery system monolith to prescription
When first, pain and discomfort will not be caused.
6, it is additionally provided with heating unit, the heat radiation that heating unit generates aid blood circulation and can accelerate drug release, into
One step improves therapeutic effect.
In conclusion the present invention provides a kind of transdermal delivery system, the transdermal delivery system include: fixed cell and
Administration unit, the fixed cell are used to the administration unit being fixed on default administering position；The administration unit with it is described
Fixed cell is detachably connected.The present invention also provides a kind of above-mentioned transdermal delivery system anti-inflammation drugs, analgesic drug product and
Application in anti-tumor drug.In technical solution provided by the invention, administration unit is set in the cavity of fixed cell, and solid
Order member is detachably connected, and in replacement, only needs to change administration unit, and when dressing there will be no pain, is effectively improved easypro
Appropriateness.A kind of transdermal delivery system provided by the invention and its application, solve in the prior art, plaster comfort level when in use
Difference and tear the technological deficiency for taking pain after.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
The embodiment of invention for those of ordinary skill in the art without creative efforts, can also basis
The attached drawing of offer obtains other attached drawings.
Fig. 1 is a kind of structural schematic diagram of transdermal delivery system in technical solution provided in an embodiment of the present invention；
Wherein, fixed cell 1, administration unit 2, heating unit 3 and adjusting unit 4.
Specific embodiment
The embodiment of the invention provides a kind of transdermal delivery system and its applications, and for solving in the prior art, plaster exists
Comfort level is poor when use and the technological deficiency for taking pain is torn after.
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
Technical staff's every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
In order to which the present invention is described in more detail, below with reference to embodiment to a kind of transdermal delivery system provided by the invention and its
Using being specifically described.
Referring to Fig. 1, the embodiment of the invention provides a kind of transdermal delivery systems, comprising: fixed cell 1 and administration unit
2, fixed cell 1 is used to administration unit 2 being fixed on default administering position；Administration unit 2 is detachably connected with fixed cell 1,
Fixed cell 1 is equipped with a cavity, and administration unit 2 is set in cavity.The embodiment of the invention provides a kind of transdermal delivery systems
And its application, for solving in the prior art, comfort level is poor when in use and the technological deficiency for taking pain is torn after for plaster.
In technical solution provided in an embodiment of the present invention, administration unit 2 is fixed on preset administration position by fixed cell 1
It sets, administration unit 2 releases drug and carries out cutaneous penetration by skin, at this point, since fixed cell 1 and administration unit 2 are removable
Connection is unloaded, so different administration units 2 can be replaced according to the dosage of different administration requirements and different phase, it is limited to keep away
Exempted to need to tear plaster monolith after drug release due to traditional plaster to user's bring tingling sensation and uncomfortable
Sense effectively optimizes user experience, improves usage comfort.
During practical application, in order to further improve the comfort level and air permeability of transdermal delivery system, especially
It is the problems such as will not causing exanthemv because of the airtight of fixed cell 1 when summer, in practical application, solid
Order member 1 can be the ventilative material such as cotton fabric, carbon cloth, Nature Fibre Textile product.
Equally, to provide diversified form of medication to different users, meet different use preference and difference
The specific administration requirements of drug, the dosage form of administration unit 2 can be gel, frozen glue shape, creams shape, graininess, nanoscale grain
Any one in a variety of dosage forms such as son, particle, or it is also possible to the combining form of wherein certain several dosage form.
Equally, drug is also possible to multiplicity, and such as: Chinese medicine, Western medicine are ok or magnet therapeutic plaster.Both it may be implemented cold
It applies, hot compress also may be implemented.
For the administration requirements for cooperating different parts, in the application, the specific administering position of transdermal delivery system is not limited,
The different structure of fixed cell 1 can be designed according to actual administering position, such as ancon, arm, leg, wrist, ankle,
The each position of the human bodies such as head, finger, toe.
In practical application, administration unit 2 can with additional labor intelligence cream piece, be applied to dermovaccine field, skin
Area of medical diagnostics, cutaneous immunisation therapy field, artificial skin smart field and skin identifying system field.
Further optimisation technique scheme promotes the absorption of the discharged drug of administration unit 2, meanwhile, promote user's
Usage experience comfort level, a kind of transdermal delivery system provided in an embodiment of the present invention further include: heating unit 3, heating unit 3 are used
In heating administration unit 2.
For the usage experience for further improving user, optimize the therapeutic effect of transdermal delivery system, the present invention is implemented
In the technical solution that example provides, heating unit 3 is infrared ray auxiliary heating element 3.
For the different types of demand for heat convenient for meeting different users, one kind provided in an embodiment of the present invention is percutaneously given
In medicine system, the temperature of heating unit 3 is adjustable.It, can be according to different topical application of drug demands and individual during actual use
For the hobby of temperature, it is adjusted to suitable temperature, meets different types of demand.
Effectively to avoid during using transdermal delivery system, there are the situations such as discomfort in user, improves using comfortable
It spends, in technical solution provided in an embodiment of the present invention, fixed cell 1 is carbon fiber fixed cell 1.
For meet different statures user's different parts administration requirements, effectively ensure that fixed cell 1 can will be administered
Unit 2 is affixed on the skin surface of user, a kind of transdermal delivery system provided in an embodiment of the present invention further include: unit 4 is adjusted,
It adjusts unit 4 to connect with fixed cell 1, for adjusting the length of fixed cell 1.
Similarly, during practical application, fixed cell 1 can also be set to a scalable fixed cell 1, equally may be used
Realize that administration unit 2 is fixed on the effect of skin surface by fixed cell 1.
Further optimisation technique scheme preferably adjusts the elasticity of fixed cell 1, skill provided in an embodiment of the present invention
In art scheme, adjusting unit 4 is an air pump.
The application range for further expanding transdermal delivery system, spreads on skin surface for different types of drug and controls
It treats, in technical solution provided in an embodiment of the present invention, the dosage form of administration unit 2 is selected from: gelling agent, gelatum agent, creams agent, particle
Any one or more in agent and nanometer agent.
During practical application, as long as can make in such a way that the skin surface topical application of drug is treated
With above-mentioned transdermal delivery system, i.e., the present invention also provides transdermal delivery system, can be widely applied to anti-inflammation drugs, anodyne
Object, anti-tumor drug, relaxing tendons and activating collaterals drug, antirheumatic drug, anti-diabetic, stop smoking medicine, cardiovascular and cerebrovascular medicine, gout
Drug, senile dementia and remove swelling drug.From above-mentioned technical proposal, it can be concluded that, one kind provided by the invention is percutaneous
Drug delivery system and its application, have the advantage that
1, administration unit and fixed cell are to be detachably connected, and can replace different administrations according to different use requirements
Unit, and, cooperate the different medication stages to adjust dosage, medication unit can take out at any time and replace at any time；
2, in replacement, no replacement is required, and fixed cell is replaced there is no need to remove transdermal delivery system monolith to prescription
When first, pain and discomfort will not be caused.
3, it is additionally provided with heating unit, the heat radiation that heating unit generates aid blood circulation and can accelerate drug release, into
One step improves therapeutic effect.
4, administration unit and fixed cell are to be detachably connected, and can replace different administrations according to different use requirements
Unit, and, cooperate the different medication stages to adjust dosage, medication unit can take out at any time and replace at any time；
5, in replacement, no replacement is required, and fixed cell is replaced there is no need to remove transdermal delivery system monolith to prescription
When first, pain and discomfort will not be caused.
6, it is additionally provided with heating unit, the heat radiation that heating unit generates aid blood circulation and can accelerate drug release, into
One step improves therapeutic effect.
In conclusion the present invention provides a kind of transdermal delivery system, the transdermal delivery system include: fixed cell and
Administration unit, the fixed cell are used to the administration unit being fixed on default administering position；The administration unit with it is described
Fixed cell is detachably connected.The present invention also provides a kind of above-mentioned transdermal delivery system anti-inflammation drugs, analgesic drug product and
Application in anti-tumor drug.In technical solution provided by the invention, administration unit is set in the cavity of fixed cell, and solid
Order member is detachably connected, and in replacement, only needs to change administration unit, and when dressing there will be no pain, is effectively improved easypro
Appropriateness.A kind of transdermal delivery system provided by the invention and its application, solve in the prior art, plaster comfort level when in use
Difference and tear the technological deficiency for taking pain after.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of transdermal delivery system, which is characterized in that the transdermal delivery system includes: fixed cell and administration unit, institute
Fixed cell is stated for the administration unit to be fixed on default administering position；
The administration unit is detachably connected with the fixed cell, and the fixed cell is equipped with a cavity, the administration unit
It is set in the cavity.
2. transdermal delivery system according to claim 1, which is characterized in that the transdermal delivery system further include: heating
Unit, the heating unit is for heating the administration unit.
3. transdermal delivery system according to claim 2, which is characterized in that the heating unit is infrared ray auxiliary heating
Unit.
4. transdermal delivery system according to claim 2 or 3, which is characterized in that the temperature of the heating unit is adjustable.
5. transdermal delivery system according to claim 1, which is characterized in that the fixed cell is that carbon fiber is fixed single
Member.
6. transdermal delivery system according to claim 1, which is characterized in that the transdermal delivery system further include: adjust
Unit, the adjusting unit is connect with the fixed cell, for adjusting the length of the fixed cell.
7. transdermal delivery system according to claim 6, which is characterized in that the adjusting unit is an air pump.
8. transdermal delivery system according to claim 1, which is characterized in that the dosage form of the administration unit is selected from: gel
Any one or more in agent, gelatum agent, creams agent, granule and nanometer agent.
9. transdermal delivery system according to claim 1, which is characterized in that the fixed cell is scalable fixed single
Member.
10. it is a kind of including transdermal delivery system described in claim 1 to 9 any one in anti-inflammation drugs, analgesic drug product, anti-swollen
Tumor medicine, relaxing tendons and activating collaterals drug, antirheumatic drug and go application in swelling drug.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910009561.0A CN109966633A (en) | 2019-01-04 | 2019-01-04 | A kind of transdermal delivery system and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910009561.0A CN109966633A (en) | 2019-01-04 | 2019-01-04 | A kind of transdermal delivery system and its application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109966633A true CN109966633A (en) | 2019-07-05 |
Family
ID=67076558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910009561.0A Pending CN109966633A (en) | 2019-01-04 | 2019-01-04 | A kind of transdermal delivery system and its application |
Country Status (1)
| Country | Link |
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| CN (1) | CN109966633A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0481939A2 (en) * | 1990-10-18 | 1992-04-22 | Mli Acquisition Corp. Ii | Twin patch applicator |
| CN204951563U (en) * | 2015-09-23 | 2016-01-13 | 尚淑梅 | Rehabilitation and nursing area |
| CN106345049A (en) * | 2016-09-07 | 2017-01-25 | 胡晋阳 | Device for far infrared traditional Chinese medicine plastering thermal therapy and manufacturing method of device |
| CN106377408A (en) * | 2016-10-31 | 2017-02-08 | 林丽芳 | Medical heat-care device |
| CN107929951A (en) * | 2017-12-26 | 2018-04-20 | 登封市绿奥农林科技有限公司 | A kind of massage waistband |
| CN208002973U (en) * | 2017-11-14 | 2018-10-26 | 贵阳中医学院第一附属医院 | Chinese medicine respiratory disease hot application belt |
| CN208243920U (en) * | 2017-07-20 | 2018-12-18 | 广州陶鑫电器有限公司 | A kind of graphene physiotherapeutic waistband |
-
2019
- 2019-01-04 CN CN201910009561.0A patent/CN109966633A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0481939A2 (en) * | 1990-10-18 | 1992-04-22 | Mli Acquisition Corp. Ii | Twin patch applicator |
| CN204951563U (en) * | 2015-09-23 | 2016-01-13 | 尚淑梅 | Rehabilitation and nursing area |
| CN106345049A (en) * | 2016-09-07 | 2017-01-25 | 胡晋阳 | Device for far infrared traditional Chinese medicine plastering thermal therapy and manufacturing method of device |
| CN106377408A (en) * | 2016-10-31 | 2017-02-08 | 林丽芳 | Medical heat-care device |
| CN208243920U (en) * | 2017-07-20 | 2018-12-18 | 广州陶鑫电器有限公司 | A kind of graphene physiotherapeutic waistband |
| CN208002973U (en) * | 2017-11-14 | 2018-10-26 | 贵阳中医学院第一附属医院 | Chinese medicine respiratory disease hot application belt |
| CN107929951A (en) * | 2017-12-26 | 2018-04-20 | 登封市绿奥农林科技有限公司 | A kind of massage waistband |
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| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190705 |
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| RJ01 | Rejection of invention patent application after publication |