CN109966461A - A kind of Chinese medicine composition and its application for treating dilated cardiomyopathy - Google Patents

A kind of Chinese medicine composition and its application for treating dilated cardiomyopathy Download PDF

Info

Publication number
CN109966461A
CN109966461A CN201910288517.8A CN201910288517A CN109966461A CN 109966461 A CN109966461 A CN 109966461A CN 201910288517 A CN201910288517 A CN 201910288517A CN 109966461 A CN109966461 A CN 109966461A
Authority
CN
China
Prior art keywords
parts
radix
chinese medicine
heart
medicine composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201910288517.8A
Other languages
Chinese (zh)
Other versions
CN109966461B (en
Inventor
李军
陈恒文
谭雨晴
武庆娟
田盼盼
高健
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guanganmen Hospital of CACMS
Original Assignee
Guanganmen Hospital of CACMS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guanganmen Hospital of CACMS filed Critical Guanganmen Hospital of CACMS
Priority to CN201910288517.8A priority Critical patent/CN109966461B/en
Publication of CN109966461A publication Critical patent/CN109966461A/en
Application granted granted Critical
Publication of CN109966461B publication Critical patent/CN109966461B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention discloses a kind of for treating the Chinese medicine composition of dilated cardiomyopathy, and the bulk pharmaceutical chemicals such as radix aconiti lateralis preparata, rhizoma zingiberis, Radix Glycyrrhizae, Radix Astragali, Radix Codonopsis, Radix Ophiopogonis, Schisandra chinensis, ramulus cinnamomi, raw oyster that the effective component of the composition is matched by constant weight are made.The Chinese medicine composition has the effect of yang-tonic tongmai, activating microcirculation and removing stasis medicinal, has significant curative effect for dilated cardiomyopathy.

Description

A kind of Chinese medicine composition and its application for treating dilated cardiomyopathy
Technical field
The present invention relates to a kind of for treating the Chinese medicine composition of dilated cardiomyopathy, belongs to tcm field.
Background technique
Summarize: dilated cardiomyopathy (Dilated Cardiomyopathy, DCM) be with the unilateral or bilateral chambers of the heart expand, Myocardium shrinkage function decline, companion or without congestive heart failure be main clinical manifestation heart disease, such as chronic heart function It can not complete, arrhythmia cordis, thromboembolism, sudden death etc..Domestic epidemiological survey discovery, 5 years case fatality rate of DCM are 80%, and 5 years case fatality rate of external DCM are about 50%, and U.S.'s epidemiological survey finds that advanced stage DCM illness rate is about 36.5/10 ten thousand, are given Patient home and society cause serious financial burden.This disease cause of disease is unknown at present, and clinical manifestation is without specificity, also without special efficacy Treatment method and drug, it is clinical mainly to improve heart function, optimization myocardial metabolism, improve arrhythmia cordis, anti-infective, prevention bolt Based on plug complication and the treatment such as delay progression of the disease.
Western medical treatment: in DCM patient's early stage, feritin-angiotensins-aldosterone system, adrenergic system quilt Activation, can cause myocardial remodelling, further result in DCM deterioration, and ACEI, ARB pass through antagonism RAAS system, beta-blocker Inhibit sympathetic activation, to inhibit myocardial remodelling, improves patient's prognosis.When DCM develops to heart failure Decompensated stage, occur Fluid retention can add inotropic agent and diuretics with digitalis, such as digoxin, frusemide, improve clinical symptoms. On the basis of application said medicine, non-digitalis positive inotropic and sorbide nitrate class can be used with terminal phase CHF in DCM in short term Drug.
Symptom cannot still be alleviated using medical treatment, it can be by surgical means.For left room systolic dyssynchrony and drug Invalid DCM heart failure patient is treated, ventricular synchronous can be made to shrink by following cardiac resynchronization therapy (CRT), improves heart function Can be with haemodynamics without increasing oxygen consumption, and then reduce the death of advanced heart failure；Pass through bone marrow stem cell Transplantation treatment DCM patient improves patients ' life quality etc. to improve the late heart function and activity tolerance of patient.Meanwhile also The heart can be improved by surgical operation, such as dynamic cardiomyoplasty art, left room volume reduction surgery, left ventricular assist, heart transplant Function, to reduce the DCM death rate.
Chinese traditional treatment: nothing " dilated cardiomyopathy " name of disease in motherland's medicine, but successive dynasties TCM Document retouching about distention related to the heart In stating, including its etiology and pathogenesis, symptom and principle of reatment etc., similitude is all had with dilated cardiomyopathy, therefore by the expanding heart Myopathy is attributed to the sick scope of Chinese medicine " distention related to the heart ".
At present country's Chinese medicine for dilated cardiomyopathy differentiation of symptoms and signs for classification of syndrome still disunity, according to ancient books and modern doctor to this The understanding of sick etiology and pathogenesis has scholar from negative and positive of qi and blood, is to treat big method with warming heart yang, activating blood and promoting diuresis, by DCM points Are as follows: type of deficiency of both QI and YIN, main side's Shengmai San plus-minus；QIXUELIANGXU type, main side's Bao Yuan Tang close guipi decoction plus-minus；Qi deficiency blood stasis type is protected First soup closes Xuefu Zhuyu Decoction；Edema due to yang insufficiency, main side's Zhen Wu Tang, Decoction for strengthening the Spleen-Yang；There is heart-yang failure card in disease to the later period, and therapy is returned for first aid Sun reinforces vital energy, and recipe Sini Jia Renshen Tang adds taste, can also use shengmai injection or Shenmai injection.There is scholar by involving Dilated cardiomyopathy is divided into 3 basic card types: type of deficiency of QI of both the heart and lung by internal organs, and Bao Yuan Tang closes Chun Zetang plus-minus；Heart-kidney yang deficiency type, very Military soup closes Sini Tang plus-minus；Type of deficiency of both QI and YIN, Shengmai San close lilii and Anemarrhenae Decoction plus-minus.In addition there is scholar according to disease progression, again By DCM divide for early stage and treatment after Restoration stage, mostly syndrome of blood stasis due to qi deficiency, control with inrigorating qi and promoting blood circulation；If gas undermines yin, or evil Poison consumption impairment of yin liquid, can behave as deficiency of both qi and yin stasis syndrome, controls with reinforcing both QI and YIN, activating microcirculation and removing stasis medicinal, can give Shengmai San, Taohong Siwu Tang Deng；When DCM develops to the heart failure stage, often have qi deficiency to blood stasis water and stop demonstrate,proving, control suitable tonifying Qi Li Shui, activating microcirculation and removing stasis medicinal, can add with five Siberian cockleburs Dissipate benefit gas row water.DCM develops to heart failure Decompensated stage, belong to deficiency of yang blood stasis causing water retention card more, controls with warming yang for diuresis, activating microcirculation and removing stasis medicinal, can Select Zhen Wu Tang, Decoction for strengthening the Spleen-Yang warming yang for diuresis.DCM develops to the terminal stage, often has syndrome of depletion of yin causing yang collapse, controls with recuperating depleted yang, can add with Shenfu dragon It is male to rescue inverse soup, Du Shen Tang.
As it can be seen that treating the field DCM in traditional Chinese medicine, therapeutic rule emphasizes particularly on different fields, feature is different, does not form consistent sight Point needs more clinical practices to explore.
Summary of the invention
It is an object of that present invention to provide a kind of new Chinese medicine compositions, according to new principle of reatment, for treating expanding Cardiomyopathy, the especially syndrome of yang deficiency and blood stasis of Chinese medicine distention related to the heart.
The effective component of Chinese medicine composition of the present invention is made of the bulk pharmaceutical chemicals of following weight proportion: radix aconiti lateralis preparata 10-30 parts, 3-10 parts of rhizoma zingiberis, 2-10 parts of Radix Glycyrrhizae, 15-30 parts of Radix Astragali, 9-30 parts of Radix Codonopsis, Radix Ophiopogonis 6-12 part, 2-6 parts of Schisandra chinensis, 3-10 parts of ramulus cinnamomi, 9-30 parts of raw oyster.
Preferably, the proportion of each bulk pharmaceutical chemicals are as follows: 20-30 parts of radix aconiti lateralis preparata, 6-10 parts of rhizoma zingiberis, 5-10 parts of Radix Glycyrrhizae, Radix Astragali 20-30 Part, 20-30 parts of Radix Codonopsis, Radix Ophiopogonis 9-12 part, 4-6 parts of Schisandra chinensis, 6-10 parts of ramulus cinnamomi, 20-30 parts of raw oyster.
Further preferably, each bulk pharmaceutical chemicals can be following any specific proportion mode:
(1) 30 parts of radix aconiti lateralis preparata, 10 parts of rhizoma zingiberis, 10 parts of Radix Glycyrrhizae, 30 parts of Radix Astragali, 30 parts of Radix Codonopsis, 12 parts of Radix Ophiopogonis, 6 parts of Schisandra chinensis, 10 parts of ramulus cinnamomi, 30 parts of raw oyster.；
(2) 20 parts of radix aconiti lateralis preparata, 6 parts of rhizoma zingiberis, 5 parts of Radix Glycyrrhizae, 20 parts of Radix Astragali, 20 parts of Radix Codonopsis, 9 parts of Radix Ophiopogonis, 4 parts of Schisandra chinensis, osmanthus 6 parts, 20 parts of raw oyster of branch.；
(3) 25 parts of radix aconiti lateralis preparata, 8 parts of rhizoma zingiberis, 8 parts of Radix Glycyrrhizae, 25 parts of Radix Astragali, 25 parts of Radix Codonopsis, 10 parts of Radix Ophiopogonis, 5 parts of Schisandra chinensis, osmanthus 8 parts, 25 parts of raw oyster of branch.
In order to improve therapeutic effect, improves patient symptom, any in following flavour of a drug can also be added according to clinical needs Any combination more than taste or two tastes: 6-15 parts of Radix Paeoniae Alba, 3-10 parts of Cortex Magnoliae Officinalis, 10-15 parts of radix rehmanniae recen, 3-10 parts of the dried immature fruit of citron orange.Preferably, The dosage of these bulk pharmaceutical chemicals is Radix Paeoniae Alba 9-12 parts, 7-9 parts of Cortex Magnoliae Officinalis, 2-13 parts of radix rehmanniae recen, 7-9 parts of the dried immature fruit of citron orange.Most common, these are former The dosage for expecting medicine is 12 parts of Radix Paeoniae Alba, 9 parts of Cortex Magnoliae Officinalis, 12 parts of radix rehmanniae recen, 9 parts of the dried immature fruit of citron orange.
It has been recognised by the inventors that dilated cardiomyopathy is by hypofunction of YANG QI in chest, caused by heart vessel blockage stasis.Deficiency of heart-YANG, exopathogen disturb the heart, sun The deficiency of vital energy decline it is powerless push blood, with the passing of time stagnation resolvation, the obstructed hair of heart vessel blockage stasis is this disease, and heart-yang virtual loss, deficiency of heart-QI, yin heresy is superior, Sering is unfavorable, not general rule pain, therefore symptoms include the symptoms such as pectoralgia, chest distress, preferably control with yang-tonic tongmai, activating microcirculation and removing stasis medicinal.Monkshood in side, Radix Codonopsis is combined into monarch drug in a prescription, the big heat of monkshood, recuperating depleted yang, mends fire supporing yang, above helps heart-yang, medium temperature spleen sun, lower kidney-replenishing, and Radix Codonopsis qi and blood is double It mends, strengthening the spleen and replenishing qi, nourishes blood and promotes the production of body fluid, two monarchs are harmonious, warmly invigorating heart yang, nourishing blood and promoting blood circulation；The sweet temperature of Radix Astragali is the key medicine of air making-up and spleen enlivening, does Jiang Xinlie is scorching, and during Wen Yang is kept, recover Yang and smooth venation mutually must be used with monkshood, " rhizoma zingiberis, keeps without walking, and monkshood is walked without keeping " Hui Yang Have immediate effect, Radix Ophiopogonis nourishing heart yin, clear away heart-fire heat, tranquilizing mind, Schisandra chinensis, Gan Wen and moisten, astringing lung-QI gas, lower nourishing kidney-yin, with Radix Codonopsis, Radix Ophiopogonis can be gone up With use, such as Shengmai San, nourishing generate fluid.Ramulus cinnamomi pungent-warm helps heart-yang, and promoting blood circulation is only palpitated from nervousness, and the warm nature of monkshood, tonneau week are helped with assistant Body, the salty-cold product of raw oyster, matter Beijing South Maxpower Technology Co. Ltd town is transquilization with heavy material.Radix Glycyrrhizae both the help motive, Yiqi and vein recovery, and this medicine is mild, row " state Monkshood toxicity, the property of anti-drug temperate-dryness drop in the function of reconciliation and all medicines always ".With the card such as deficiency of blood yin deficiency is seen, add Radix Paeoniae Alba, blood-nourishing is held back Yin, soft liver analgesic；With seeing that retention of phlegmatic dampness etc. demonstrate,proves, Piao, eliminating dampness dissolving phlegm, during lower gas is wide are thickeied；With the card such as yin asthenia generating intrinsic heat is seen, add Radix Rehmanniae Huang, blood system of joining the army, clearing heat and cooling blood, nourishing Yin and promoting production of body fluid；Card is waited with seeing that feeling of fullness is not relaxed, adds dried immature fruit of citron orange relieving stagnant Qi except full, promoting qi circulation and relieving pain.Full side's group Fang Yanjin, concurrence yang-tonic tongmai, the function of activating microcirculation and removing stasis medicinal.
Beneficial effect
For the effect for verifying technical solution of the present invention, inventor has successively carried out animal effect experiment and has ground with clinical efficacy Study carefully, and has carried out Contrast on effect with another existing prescription.Research process and result are as follows.
Experiment one: animal drug efficacy study
1.1 experimental animal
Male Wistar rat totally 120, weight (200 ± 10) g, SPF grade, have purchased from Beijing dimension tonneau China experimental animal Limit company, production licence number SCXK (capital) 2015-0007.By wanting for the related zooscopy guideline of the Chinese Ethical committee It asks, raising is in China Academy of Sciences Guanganmen Hospital animal house, indoor maintaining constant temperature state (25 ± 1 DEG C), feed and drinking-water Without restriction, standard feed is fed.
1.2 key instrument
SSD-5000 doppler ultrasound (Japan, Aloka company), BSA1245 electronic analytical balance (Germany, Sartorius company), PowerLab polygraph (Australia, Adinstruments company), HX-300 animal Ventilator (Chengdu TME Technology Co., Ltd.).
1.3 experimental drug
From quasi- expansion heart side, side are as follows: radix aconiti lateralis preparata 25g (being decocted first), rhizoma zingiberis 8g, Radix Glycyrrhizae 8g, Radix Astragali 25g, Radix Codonopsis 25g, Radix Ophiopogonis 10g, Schisandra chinensis 5g, ramulus cinnamomi 8g, raw oyster 25g (being decocted first).
The heart tonifying side of promoting blood circulation, side are as follows: radix aconiti lateralis preparata (is decocted first) 15g, ginger 10g, radix glycyrrhizae preparata 10g, Radix Astragali 50g, ginseng 20g, osmanthus Branch 20g, Rhizoma Atractylodis Macrocephalae 15g, Poria cocos 15g, Radix Paeoniae Alba 15g, Radix Angelicae Sinensis 15g, peach kernel 15g, safflower 10g.
1.4 expand the foundation and grouping of heart trouble rat model
By to injecting doxorubicin hydrochloride modeling in rat abdominal cavity: experimental group we by adriamycin be with normal saline dilution 2mg/mL, by lower abdomen straight line, intraperitoneal injection.Totally 6 times, each 2.5mg/kg, every rat co-injection 15mg/ in two weeks The case where kg, control group is injected intraperitoneally the physiological saline of equivalent volumes, during which observes them daily.Two after stopping injection adriamycin In week, verify whether modeling succeeds by transthoracic echocardiography detection.
Experimental group: dividing them into 4 groups, normal group, expand heart trouble group, expands heart trouble+certainly quasi- expansion heart side's low dose group (1.35g extract kg-1·d-1), expand heart trouble+certainly quasi- expansion heart side's high dose group (5.40g extract kg-1·d-1), expand the heart Disease+heart tonifying the side of promoting blood circulation low dose group (1.87g extract kg-1·d-1), expand the heart trouble+heart tonifying side of promoting blood circulation high dose group (7.50g Extract kg-1·d-1).Middle dose group dosage is 70kg weight adult equivalent dose (converting by body surface area), high agent Amount is 2 times of 70kg weight adult equivalent dose (converting by body surface area), and low dose group is 1/2 times of adult equivalent dose, Drinking-water and feed are normally given, is raised 12 weeks, daily stomach-filling 1 time.
1.5 overview
Main detection appearance hair color, activity condition, the state of mind, food-intake, amount of drinking water, weight, excrement etc..
There is no rats death in experimentation.During treatment, except for the normal group, remaining each group rat occurs in various degree The symptoms such as syntexis, depilation, anorexia, loose stool, weight loss, wherein the most serious to expand heart trouble model group rats symptom, and from Quasi- heart side's group surviving rats state that expands has clear improvement, hence it is evident that better than the heart tonifying side of promoting blood circulation group.
The detection of 1.6 heart functions
Chest shaving preserved skin is fixed on by each group rat with 10% chloraldurate through intraperitoneal anesthesia with carrying on the back position before materials Station carries out Cardiac ultrasound, measures left ventricular end diastolic (LvIDd), end systolic diameter (LVIDs), and left room is short Axis shortening rate (LVFS), left ventricular ejection fraction (LVEF).
Influence of 1 XBF of table to Rat of Myocardial Infarction heart function
Note: compared with normal group:1)P<0.01；Compared with expanding heart trouble group:3)P < 0.05,4)P<0.01。
Detect the cardiac function and structure of each group rat, LvIDd and LVIDs respectively with animal specific echocardiograph More normal group is (P < 0.01) significantly increased in expanding heart trouble group, and is (P < 0.01) being obviously reduced from expansion heart side is intended, and Better than the heart tonifying side of promoting blood circulation group；LVFS and LVEF is (P < 0.01) being substantially reduced for more normal group in expanding heart trouble group, and is expanded from quasi- Heart side's group is then obviously improved (P < 0.01), and the heart tonifying side of promoting blood circulation group LVEF function makes moderate progress, but is not obvious, and is expanded heart side's group and is existed Improve and is substantially better than metancenter soup group on the heart functions such as LVFS and LVEF.
Experiment two: lanqin oral solutions
2.1 test objectives: paired observation treats the clinical efficacy of dilated cardiomyopathy from quasi- heart side and the heart tonifying side of promoting blood circulation of expanding With safety.
2.2 research contents:
2.2.1 research object: being included in clinical diagnosis is dilated cardiomyopathy 60, and case is 2012.06- The dilated cardiomyopathy that 2018.06 China Academy of Sciences Guanganmen Hospital Cardiological outpatient service wards are accepted for medical treatment.
Diagnostic criteria: diagnostic criteria refers to nineteen ninety-five WHO/ISFC standard, cardiovascular disease branch, Chinese Medical Association in 2007 DCM diagnostic criteria of proposition etc., cardiac functional grading belong to II-IV grade by USA New York heart disease association (NYHA) classification.Through detailed The auxiliary examinations such as electrocardiogram, cardiac ultrasonic clarify a diagnosis as dilated cardiomyopathy and exclude vital myocarditis, the rheumatic heart The specific organic heart disease of other causes of disease such as myopathy, congenital heart disease, coronary atherosclerotic heart disease.
It is included in standard: 1. meeting above-mentioned diagnostic criteria；2. the age 18-70 years old, male or female, patient signed informed consent Book；3. not taking other Chinese materia medica preparations of suiting the medicine to the illness in nearly 2 weeks.
Exclusion criteria: 1. there is serious hepatic and renal function and damage the wounded, tumour and mental patient etc.；2. gestation, nursing period woman Female；3. merging severe cardiac, liver, kidney, blood, the nervous system disease person；4. patients such as other reasons are mismatched, compliance differences.
2.2.2 experimental design: 60 patients being included in are divided into treatment group (30) and control group according to random digits table (30)
2.2.3 treatment method: two groups are given conventional western medicine treatment, and treatment group expands the heart on basis of conventional therapy plus with from quasi- Side, side are as follows: radix aconiti lateralis preparata 30g (is decocted first), rhizoma zingiberis 10g, radix glycyrrhizae preparata 10g, Radix Astragali 30g, Radix Codonopsis 30g, Radix Ophiopogonis 12g, Schisandra chinensis 6g, osmanthus Branch 10g, raw oyster 30g (is decocted first).It is added and subtracted with disease.It daily 1 dose, is decocted in water for oral dose, 2 sub-services, 2 months are 1 course for the treatment of, are continuously taken 3 courses for the treatment of.Control group is on basis of conventional therapy plus with the heart tonifying side of promoting blood circulation, side are as follows: radix aconiti lateralis preparata (is decocted first) 15g, ginger 10g, toast Radix Glycyrrhizae 10g, Radix Astragali 50g, ginseng 20g, ramulus cinnamomi 20g, Rhizoma Atractylodis Macrocephalae 15g, Poria cocos 15g, Radix Paeoniae Alba 15g, Radix Angelicae Sinensis 15g, peach kernel 15g, safflower 10g.It is added and subtracted with disease.It daily 1 dose, is decocted in water for oral dose, 2 sub-services, 2 months are 1 course for the treatment of, are continuously taken 3 course for the treatment of.
2.2.4 observation index: 1. Symptom Observation: the efficacy determination formulated referring to " new Chinese medicine guideline of clinical investigations " Standard.Effective: heart function improves II grade or more, and symptom, sign and every parameters of left ventricular function significantly improve；It is effective: the heart after treatment Function improves I grade, and symptom, sign and every parameters of left ventricular function make moderate progress；Invalid: heart function is not improved or aggravates.② Cardiac ultrasonic index of correlation observes Left Ventricular Ejection Fraction (LVEF), left ventricular end diastolic diameter (LVEDD), heart rate (HR) 3. 6 minutes Walking distance；4. safety indexes: blood urine just conventional, hepatic and renal function inspection, record adverse drug reaction etc..
2.2.5 statistical method: all statistical data are analyzed using SPSS20.0 software, and measurement data is using variance point Analysis, it is statistically significant to be set to difference for P < 0.05.
2.3 ordinary circumstance
Being included in clinical diagnosis is dilated cardiomyopathy 60, and case is 2012.06-2018.06 China department of traditional Chinese medicine The dilated cardiomyopathy that institute's Gate of Pervasive Peace heart internal medicine in hospital outpatient service ward is accepted for medical treatment.It is divided into two groups according to table of random number.It controls Treatment group 30, male 17, female 13, the age 28-70 year old, average age (42.5 ± 7.2) year, expand heart trouble course of disease 3-20, it is flat The equal course of disease is (9.5 ± 5.2) year；Control group 30, male 19, female 11, the age 31-68 years old, average age (40.3 ± 8.3) In year, expand heart trouble course of disease 4-19, average course of disease is (8.1 ± 6.7) year.Two groups in basic datas such as gender, age, the courses of disease without system Meter learns difference (P > 0.05).
2.4 result
2.4.1 Clinical efficacy comparison
Treatment group's total effective rate 93.3%, control group total effective rate 86.7%, treatment group's effective percentage are higher than control group (P < 0.05)。
2 Clinical efficacy comparison of table
2.4.2 cardiac ultrasonic index of correlation
Treatment group and each parameter index of the pretherapy and post-treatment cardiac ultrasonic of control group have improvement, and treatment group improves more compared with control group Obviously, two groups of contrast differences have statistical significance (P < 0.05).Two groups of pretherapy and post-treatment left ventricular end diastolic diameter and ejection fraction As shown in the table.
3 cardiac ultrasonic result of table
2.4.3 heart rate
Treatment group and control group have significant advantage in terms of adjusting heart rate, and pretherapy and post-treatment difference is obvious, but two groups are not deposited At statistical difference (P > 0.05).
4 heart rate of table adjusts situation
2.4.4 6 minutes walking distances
Treatment group and control group increase 6 minutes walking distances, and pretherapy and post-treatment difference is obvious, and two groups that there are statistics is poor Different (P < 0.05).
56 minutes walking distances of table
2.4.5 adverse reaction
Two groups occur without hepatic and kidney function obstacle, arrhythmia cordis 1 during treatment group's treatment, the rhythm of the heart during control group is treated Not normal 2, difference does not have statistical significance (P > 0.05).
2.5 result
Treatment group's total effective rate is 93.3%, and control group total effective rate is 83.3%, and two groups have statistical difference, together When, for improve heart function, improve symptom, the optimization heart it is super it is related treat the symptoms, exercise tolerance etc., treatment group is also significantly better than pair According to group (P < 0.05).There is certain adjustment effect for two groups of heart rate.Adverse Event incidence is lower, and does not have It is statistically significant.
2.6 conclusion
Combine conventional western medicine treatment dilated cardiomyopathy that there is better curative effect compared with the heart tonifying side of promoting blood circulation from quasi- expansion heart side, it can be bright It is aobvious to improve Cardiac Function of Patients, improve symptom, improve ejection fraction, shorten left room diastole end of term diameter, increase walking distance, adjust the heart Rate, and it is highly-safe, it is worthy of further application.
Specific embodiment
Following selected part clinical typical case proves the concrete application mode of technical solution of the present invention.In practical application, More cases can prove the prescription and dosage of technical solution of the present invention covering, can obtain similar effect.
Embodiment 1: patient field, female, 40 years old, first visit on March 7 in 2017.
Main suit: discontinuity asthma is suppressed more than 1 year.
Present illness history: patient's in March, 2016 suppresses without breathing heavily after obvious inducement appearance activity, night suppress it is awake, by systematic treating disease Shape mitigates.In December, 2016, medical in General Hospital, Shenyang Military Command, row cardiac ultrasonic showed: atrium sinistrum 44mm because of symptom recurrent exerbation, Left ventricle 56mm, left posterior wall 10mm, chamber interval thickness 10mm, EF:39%, FS:19%.Prompt: whole-heartedly increase, heart function subtracts It is low；Two tritubercular cycloids (slight)；Pulmonary hypertension (slight).Non- row special treatment, to improve symptom, the outpatient service of Sui Lai our hospital is just It examines.
It inscribes disease: being suppressed without obvious asthma, no shortness of breath and fatigue, night can lie down, without suppressing awake, double lower limb oedema, chilly, night sweat, Without dry mouth with bitter taste, temper is anxious, receive can, difficulty falling asleep, 1 row of day of defecating, forming, matter is dry, and urine amount is few.
Tongue vein: pink tongue, tongue fur is thin white, veins string.
Past medical history: hypertension monitors blood pressure 120-130/80-90mmHg.
It now takes medicine: Betaloc 25mg bid, dabigatran etcxilate 10mg bid
Diagnosis: tcm diagnosis: distention related to the heart card type: syndrome of yang deficiency and blood stasis
Doctor trained in Western medicine diagnosis: dilated cardiomyopathy；Hypertension
Therapy: yang-tonic tongmai, activating microcirculation and removing stasis medicinal
Prescription: radix aconiti lateralis preparata 30g (being decocted first), rhizoma zingiberis 9g, Radix Glycyrrhizae 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Ophiopogonis 12g, Schisandra chinensis 6g, Ramulus cinnamomi 10g, raw oyster 30g (being decocted first)
On April 11st, 2017, two examine:
Inscribe disease: taking all disease in top and alleviate, double lower limb oedema is alleviated, and chilly, night sweat mitigate, receive can, sleep improves, greatly Just day a line, forming, matter can, urine amount is few.
Tongue vein: pink tongue, tongue fur is thin white, veins string.
Prescription: radix aconiti lateralis preparata 30g (being decocted first), rhizoma zingiberis 9g, Radix Glycyrrhizae 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Ophiopogonis 12g, Schisandra chinensis 6g, Ramulus cinnamomi 10g, raw oyster 30g (being decocted first), Radix Rehmanniae 12g, Radix Paeoniae Alba 12g, dried immature fruit of citron orange 9g
Note: square foundation adds the radix rehmanniae recen with sweet cold matter profit, and the blood-head of removing summer-heat ying blood point is supported with compatibilities, heat-clearing such as Radix Ophiopogonis Yin and promoting production of body liquid, the Schisandra chinensis that compatibility acid is held back restrain hidroschesis, care for shield body fluid, sweet cold property can restrict monkshood again, rhizoma zingiberis warms it Property；Add Radix Paeoniae Alba and ramulus cinnamomi compatibility, harmonizing yingfen and weifen；The dried immature fruit of citron orange is pungent to open bitter drop, and disappear in the heart full bored.
On August 8th, 2017, three examine:
Inscribe disease: unparalleled edema of lower extremity, easy sweating, no dry mouth with bitter taste, even sighing frequently, abdominal distension is unrelated with feed, no sour regurgitation Heartburn, the peace that can sleep is received in no asthma, day 3-4 row of defecating, shapeless, and urine amount is few.
Tongue vein: pink tongue, tongue fur is thin white, veins string.
Prescription: radix aconiti lateralis preparata 30g (being decocted first), rhizoma zingiberis 9g, Radix Glycyrrhizae 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Ophiopogonis 12g, Schisandra chinensis 6g, Ramulus cinnamomi 10g, raw oyster 30g (being decocted first), Radix Rehmanniae 12g
Note: being added Radix Rehmanniae in square foundation, and clearing heat and nourishing yin is promoted the production of body fluid, the Schisandra chinensis that compatibility acid is held back, and restrains hidroschesis, cares for shield saliva Liquid prevents sweating impairment of yin.
On August 21st, 2018, the four methods of diagnosis:
Inscribe disease: symptom is obviously improved therefore breaks and take traditional Chinese medicine May, and January, cause hot weather, even to feel chest distress, in cool place Place, which voluntarily take a momentary rest, can be relieved.Even dizzy, sweat is more, receives the peace that can sleep, and stool 2 row of day is shapeless, small.
Tongue vein: pink tongue has indentation, and tongue fur is thin white, forceless deep pulse.
Auxiliary examination: Color Sonography: left atrial diameter 36mm, internal diameter of right ventricle 24mm, chamber interval thickness 8mm, left room end-diastolic Internal diameter 49mm, left ventricular posterior wall thickness 8mm, chamber interval thickness 8mm, EF:57%, FS:29%.Prompt: intracardiac structure is substantially normal, Diastole Function lowers；Left room overall shrinkage function is normal under quiescent condition.
Prescription: radix aconiti lateralis preparata 30g (being decocted first), rhizoma zingiberis 9g, Radix Glycyrrhizae 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Ophiopogonis 12g, Schisandra chinensis 6g, Ramulus cinnamomi 10g, raw oyster 30g (being decocted first), dried immature fruit of citron orange 15g, Cortex Magnoliae Officinalis 9g
Note: in the dosage of the square foundation increasing dried immature fruit of citron orange, effect is more high violent, and relieving stagnant Qi is scattered full bored in the heart except completely, opening；Summer heat is smoked It steams, appropriate Cortex Magnoliae Officinalis, eliminating dampness dissolving phlegm, ventilating is added.
Embodiment 2: patient's Mr. Wang, male, 47 years old, first visit on December 13 in 2014.
Main suit: paroxysmal chest distress more than 1 year.
Present illness history: there is chest distress without obvious inducement within patient 2013.Medical in local county people's hospital, row heart is super Sound shows: atrium sinistrum 40mm, left ventricle 59mm, right ventricle 18mm, left posterior wall 7mm, EF:58%, FS:29%.Prompt: Zuo Xinzeng Greatly；Mitral regurgitation (slight)；Tricuspid regurgitation (slight).Conventional therapy is not improved, Sui Lai our hospital outpatient clinic.
Inscribe disease: paroxysmal is uncomfortable in chest, feels suffocated, and without awake, out of strength, shortness of breath is suppressed, chilly is timid easily frightened, tinnitus, no dry mouth Hardship, receives the peace that can sleep, day a line of defecating, forming, matter can, it is small.
Tongue vein: tongue is dark red, moss thin yellow, and arteries and veins is thin.
Diagnosis: tcm diagnosis: distention related to the heart card type: syndrome of yang deficiency and blood stasis
Doctor trained in Western medicine diagnosis: dilated cardiomyopathy
Therapy: yang-tonic tongmai, activating microcirculation and removing stasis medicinal
Prescription: radix aconiti lateralis preparata 30g (being decocted first), rhizoma zingiberis 9g, Radix Glycyrrhizae 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Ophiopogonis 12g, Schisandra chinensis 6g, Ramulus cinnamomi 10g, raw oyster 30g (being decocted first), Radix Rehmanniae 12g
Note: Radix Rehmanniae is added in square foundation, can not only restrict the property of monkshood, rhizoma zingiberis temperate-dryness, but also can nourish the heart-yin.
On April 9th, 2015, two examine:
Inscribe disease: chest distress is alleviated after taking top, lacks of energy and shortness of breath improvement, receives the peace that can sleep, two just adjust.
Auxiliary examination: cardiac ultrasonic: atrium sinistrum 36mm, left ventricle 56mm, left posterior wall 9mm, EF:64%, FS:30%. Prompt: left room is bigger；Mitral regurgitation (slight)；Tricuspid regurgitation (slight)；Diastole Function lowers.
Tongue vein: tongue is dark red, moss thin yellow, small and wiry pulse.
Prescription: radix aconiti lateralis preparata 30g (being decocted first), rhizoma zingiberis 9g, Radix Glycyrrhizae 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Ophiopogonis 12g, Schisandra chinensis 6g, Ramulus cinnamomi 10g, raw oyster 30g (being decocted first), Radix Rehmanniae 12g, Radix Paeoniae Alba 12g
Note: with the passing of time, tongue color is dark red for patient's blood stasis, moss thin yellow, square foundation addition Radix Rehmanniae, Radix Paeoniae Alba, blood system of joining the army, and heat-clearing is cool Yin is held back in blood, blood-nourishing.
On August 29th, 2015, three examine:
Inscribe disease: all diseases alleviates, even palpitaition, receives the peace that can sleep, and two just adjust.
Auxiliary examination: cardiac ultrasonic: atrium sinistrum 34mm, left ventricle 49mm, left posterior wall 8mm, EF:65%, FS:30%. Prompt: mitral regurgitation (slight)；Tricuspid regurgitation (slight).
Tongue vein: pale tongue is dark, moss thin yellow, veins string.
Prescription: radix aconiti lateralis preparata 30g (being decocted first), rhizoma zingiberis 9g, Radix Glycyrrhizae 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Ophiopogonis 12g, Schisandra chinensis 6g, Ramulus cinnamomi 10g, raw oyster 30g (being decocted first), Radix Paeoniae Alba 12g
Note: stagnant heat is gradually light, removes Radix Rehmanniae, still plus Radix Paeoniae Alba, deposits the benefits of yin is held back in its blood-nourishing, compatibility ramulus cinnamomi, harmonizing yingfen and weifen.
Embodiment 3: patient it is smooth certain, female, 53 years old, first visit on January 27 in 2015.
Main suit: paroxysmal chest distress more than 1 year.
Present illness history: there is chest distress without obvious inducement within patient 2014.On January 26th, 2015 is in the Chinese People's Liberation Army 305th hospital admission, row cardiac ultrasonic show: whole-heartedly expanding, based on left ventricular enlargement, left atrial diameter about 53 × 57 × 72mm is left Room anteroposterior diameter about 62mm, right room about 42 × 61mm, right ventricle's anteroposterior diameter about 33mm；Locular wall and chamber interval thickness no abnormality seen, movement Amplitude power is not equal, generally weakens.Front and back cavum pericardiale is visited and opaque dark area of fluid, thick about 5.9mm, 4.8mm respectively.Right ventricular apex Portion is visited and more small beam structure.Each valve form, echo no abnormality seen, open reduced activity.Two, a large amount of anti-in tricuspid valve Stream, a small amount of reflux of aorta petal.EF:38%, FS:19%.It is diagnosed as dilated cardiomyopathy.Non- row special treatment carrys out our hospital's door It examines medical.
Inscribe disease: paroxysmal chest distress, it is out of strength, it is dynamic then more so.Without dry mouth with bitter taste, no sour regurgitation is heartburn, receives the peace that can sleep, greatly Just day a line, forming, matter can, it is small.
Tongue vein: pale tongue is dark, and tongue fur is thin white, weak pulse.
Diagnosis: tcm diagnosis: distention related to the heart card type: syndrome of yang deficiency and blood stasis
Doctor trained in Western medicine diagnosis: dilated cardiomyopathy
Therapy: yang-tonic tongmai, activating microcirculation and removing stasis medicinal
Prescription: radix aconiti lateralis preparata 30g (being decocted first), rhizoma zingiberis 9g, Radix Glycyrrhizae 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Ophiopogonis 12g, Schisandra chinensis 6g, Ramulus cinnamomi 10g, raw oyster 30g (being decocted first), Radix Paeoniae Alba 12g
Note: the Radix Paeoniae Alba of benefiting yin blood, the ramulus cinnamomi of compatibility warming and activating meridian, harmonizing yingfen and weifen, the medicines such as Compatibility with Radix Astragali are added in square foundation Object can replenish qi to invigorate the spleen again, and yin is held back in blood-nourishing.
On 2 16th, 2016, two examined:
Inscribe disease: all diseases alleviates, even out of strength, receives the peace that can sleep, and two just adjust.
Auxiliary examination: cardiac ultrasonic: atrium sinistrum, room expand, and left atrial diameter about 41 × 46 × 58mm, left room anteroposterior diameter is about 52mm, right chamber diameter is in range of normal value；Locular wall and chamber interval thickness no abnormality seen, motion amplitude power speed differ.Pericardium Chamber no abnormality seen.Each valve form, echo, movable no abnormality seen.The a small amount of reflux of bicuspid valve, tricuspid valve, aorta petal.EF: 56%, FS:32%.
Tongue vein: pale tongue, tongue fur is thin white, veins string.
Prescription: radix aconiti lateralis preparata 30g (being decocted first), rhizoma zingiberis 9g, Radix Glycyrrhizae 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Ophiopogonis 12g, Schisandra chinensis 6g, Ramulus cinnamomi 10g, raw oyster 30g (being decocted first), Radix Rehmanniae 12g, Radix Paeoniae Alba 12g
Note: the Radix Paeoniae Alba of benefiting yin blood, the ramulus cinnamomi of compatibility warming and activating meridian, harmonizing yingfen and weifen, the medicines such as Compatibility with Radix Astragali are added in square foundation Object can replenish qi to invigorate the spleen again, and yin is held back in blood-nourishing.Radix rehmanniae recen, the drugs such as compatibility Radix Ophiopogonis, Schisandra chinensis is added, clearing heat and nourishing yin is promoted the production of body fluid.
Embodiment 4: patient pays certain, female, and 50 years old, first visit on April 12 in 2016.
Main suit: pectoralgia more than 2 years after activity.
Present illness history: two years ago mostly occurs with after activity or after nervous, rests 5 minutes because there is pectoralgia after unhappy Left and right can voluntarily be alleviated.On January 12nd, 2016 in Fuwai Hospital's outpatient clinic, ultrasonic cardiography diagram: left atrium diameter l is looked into 35mm, left ventricular end diastolic diameter 54mm, left ventricular posterior wall thickness 8mm, chamber interval thickness 9mm, EF:54%.Prompt: Zuo Xinzeng Greatly, regional wall motion abnormality, left heart function lower, and aorta petal is micro to backflow.Conventional western medicine treatment, symptom improve slightly Mitigate, it is now to our hospital further to improve.
Inscribe: pectoralgia after activity, without uncomfortable in chest, palpitation, without out of strength, no chilly, no dry mouth with bitter taste, day a line of defecating, matter is dry, Amount is few laborious, receives the peace that can sleep.
Tongue vein: pale tongue is dark, and tongue fur is thin white, weak pulse.
Diagnosis: tcm diagnosis: distention related to the heart card type: syndrome of yang deficiency and blood stasis
Doctor trained in Western medicine diagnosis: dilated cardiomyopathy
Therapy: yang-tonic tongmai, activating microcirculation and removing stasis medicinal
Prescription: radix aconiti lateralis preparata 30g (being decocted first), rhizoma zingiberis 9g, Radix Glycyrrhizae 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Ophiopogonis 12g, Schisandra chinensis 6g, Ramulus cinnamomi 10g, raw oyster 30g (being decocted first), dried immature fruit of citron orange 9g
Note: square foundation adds with the dried immature fruit of citron orange, the pungent row hardship drop of the dried immature fruit of citron orange, can promoting the circulation of qi resolving sputum with disappear ruffian and with relieving stagnant Qi except it is full only Bitterly, clear phlegm is turbid, vibration chest sun.
3 days two May in 2016 examines:
Inscribe disease: symptom after taking medicine improve, bitter taste, receive can, even difficulty falling asleep, two just adjust.
Tongue vein: pink tongue, tongue fur is thin white, veins string.
Prescription: radix aconiti lateralis preparata 30g (being decocted first), rhizoma zingiberis 9g, Radix Glycyrrhizae 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Ophiopogonis 12g, Schisandra chinensis 6g, Ramulus cinnamomi 10g, raw oyster 30g (being decocted first), dried immature fruit of citron orange 9g, Radix Paeoniae Alba 12g
Note: square foundation adds with the dried immature fruit of citron orange, Radix Paeoniae Alba, and the dried immature fruit of citron orange, ramulus cinnamomi share, rouse oneself chest sun, solution in the heart full bored, relieving stagnant Qi except it is full only Bitterly；Yin is held back in Radix Paeoniae Alba blood-nourishing.
It examines on August 30, three 2016:
Inscribe disease: it is out of strength obvious, have phlegm in larynx, pharynx is itched, and phlegm white matter is glutinous, shortness of breath, no dry mouth with bitter taste, receive can, sleep it is simple and easy wake up, Matter of defecating is dry, and matter is glutinous, small.
Tongue vein: pink tongue, tongue fur is thin white, veins string.
Prescription: radix aconiti lateralis preparata 30g (being decocted first), rhizoma zingiberis 9g, Radix Glycyrrhizae 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Ophiopogonis 12g, Schisandra chinensis 6g, Ramulus cinnamomi 10g, raw oyster 30g (being decocted first), Cortex Magnoliae Officinalis 9g, Radix Paeoniae Alba 12g
Note: square foundation adds with Cortex Magnoliae Officinalis, Radix Paeoniae Alba, and turbid phlegm obstructing lung, Cortex Magnoliae Officinalis is eliminating dampness and eliminating phlegm, and lower gas is relievingd asthma.
The four methods of diagnosis on November 15 in 2016:
Inscribe disease: pectoralgia, symptom uncomfortable in chest mitigate earlier above, even dry mouth with bitter taste, easily raw canker sore, no dizziness headache, receive dormancy Can, 1 row of day of defecating, matter is partially dry, urine tune.
Tongue vein: tongue body hypertrophy, tongue fur is thin white, veins string.
Auxiliary examination: ultrasonic cardiography diagram: left atrium diameter l 29mm, left ventricular end diastolic diameter 49mm, left posterior wall is looked into Thickness 8mm, chamber interval thickness 9mm, EF:66%.Prompt: intracardiac structure and blood flow no abnormality seen under quiescent condition.
Prescription: radix aconiti lateralis preparata 30g (being decocted first), rhizoma zingiberis 9g, Radix Glycyrrhizae 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Ophiopogonis 12g, Schisandra chinensis 6g, Ramulus cinnamomi 10g, raw oyster 30g (being decocted first), Radix Paeoniae Alba 12g
Note: behind clothes top, the symptoms such as phlegm retention mitigate, and go Cortex Magnoliae Officinalis, still deposit the function that yin is held back in Radix Paeoniae Alba blood-nourishing.
Embodiment 5: patient's Mr. Wang, male, 26 years old, the first visit on the 18th of August in 2015.
Main suit: more than January uncomfortable in chest.
Present illness history: patient caught a cold at the beginning of 6 months this year.There is symptom uncomfortable in chest in July, goes to a doctor in local county people's hospital, Cha Xin Dirty ultrasound is shown: atrium sinistrum: 47mm, left ventricle: 58mm, right ventricle: 20mm, left ventricular posterior wall thickness: 10mm, EF:44%, FS: 22%.Prompt: the left heart increases, and mitral regurgitation is (slight) with tricuspid regurgitation (slight), and left heart function lowers, hydropericardium. It is diagnosed as vital myocarditis, later Beijing is medical.PLA Air Force General Hospital's cardiac ultrasonic: meet the expanding heart Myopathy changes, cardiac insufficiency, a small amount of hydrops of pericardium.Left room expands obvious left locular wall interventricular septum motion amplitude and generally lowers, and transports It is dynamic to owe to coordinate.(shrink end/end-diastolic) anteroposterior diameter 59/74mm, transverse diameter 59/66mm, major diameter 84/92mm, rear wall thickness 11mm, between room Every 11mm.Right ventricle: anteroposterior diameter 27mm, minor axis 32mm, major diameter 75mm, efferent tract 33mm.EF:38%, FS:17%.It is now into one It is to our hospital that step improves symptom.
Inscribe: even uncomfortable in chest, activity is few usually, profuse perspiration, halitosis, no dry mouth with bitter taste, receive dormancy can, two just adjust.
Tongue vein: tongue is red, tongue body hypertrophy, and tongue fur is thin white, deep wiry pulse.
Diagnosis: tcm diagnosis: distention related to the heart card type: syndrome of yang deficiency and blood stasis
Doctor trained in Western medicine diagnosis: dilated cardiomyopathy
Therapy: yang-tonic tongmai, activating microcirculation and removing stasis medicinal
Prescription: radix aconiti lateralis preparata 30g (being decocted first), rhizoma zingiberis 9g, Radix Glycyrrhizae 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Ophiopogonis 12g, Schisandra chinensis 6g, Ramulus cinnamomi 10g, raw oyster 30g (being decocted first), Radix Rehmanniae 12g, dried immature fruit of citron orange 9g
Note: Radix Rehmanniae, the dried immature fruit of citron orange is added in square foundation, the heat to purify the blood point, nourishing Yin and promoting production of body fluid and blood gas, qi and blood tune then all kinds of diseases and ailments oneself Disappear.
It examines on 2 24th, 2016 two:
Inscribe disease: improvement uncomfortable in chest, no dry mouth with bitter taste, remaining no significant discomfort, receive dormancy can, two just adjust.
Tongue vein: tongue body hypertrophy, tongue fur is thin white, veins string.
Auxiliary examination: cardiac ultrasonic shows: atrium sinistrum 38mm, left room: (shrinking end/end-diastolic) anteroposterior diameter 33/50mm, transverse diameter 30/45mm, major diameter 62/75mm, rear wall thickness 9mm, remaining each intracavitary diameter normal range (NR) of chamber.EF:59%, FS:30%.Prompt: the heart Accumulation of yin cold in viscera structure is shown no obvious abnormalities, and Diastole Function lowers, and contractile function is normal.
Prescription: radix aconiti lateralis preparata 30g (being decocted first), rhizoma zingiberis 9g, Radix Glycyrrhizae 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Ophiopogonis 12g, Schisandra chinensis 6g, Ramulus cinnamomi 10g, raw oyster 30g (being decocted first), Cortex Magnoliae Officinalis 9g
Note: Cortex Magnoliae Officinalis is added in square foundation, looks into patient's tongue vein, thickeies the medicine warms sun such as Piao Peiwu monkshood, rhizoma zingiberis, ramulus cinnamomi It is wet, dispel relieve boredom chest water drink.
65 groups of typical case therapeutic effects of table

Claims (8)

1. a kind of for treating the Chinese medicine composition of dilated cardiomyopathy, it is characterised in that the effective component of the composition is by such as Made of the bulk pharmaceutical chemicals of lower weight proportion: 10-30 parts of radix aconiti lateralis preparata, 3-10 parts of rhizoma zingiberis, 2-10 parts of Radix Glycyrrhizae, 15-30 parts of Radix Astragali, Radix Codonopsis 9-30 parts, Radix Ophiopogonis 6-12 part, 2-6 parts of Schisandra chinensis, 3-10 parts of ramulus cinnamomi, 9-30 parts of raw oyster.
2. Chinese medicine composition according to claim 1, it is characterised in that the proportion of each bulk pharmaceutical chemicals are as follows: 20-30 parts of radix aconiti lateralis preparata is done 6-10 parts of ginger, 5-10 parts of Radix Glycyrrhizae, 20-30 parts of Radix Astragali, 20-30 parts of Radix Codonopsis, Radix Ophiopogonis 9-12 part, 4-6 parts of Schisandra chinensis, ramulus cinnamomi 6-10 Part, 20-30 parts of raw oyster.
3. Chinese medicine composition according to claim 2, it is characterised in that the proportion of each bulk pharmaceutical chemicals are as follows: 30 parts of radix aconiti lateralis preparata, rhizoma zingiberis 10 parts, 10 parts of Radix Glycyrrhizae, 30 parts of Radix Astragali, 30 parts of Radix Codonopsis, 12 parts of Radix Ophiopogonis, 6 parts of Schisandra chinensis, 10 parts of ramulus cinnamomi, 30 parts of raw oyster.
4. Chinese medicine composition according to claim 2, it is characterised in that the proportion of each bulk pharmaceutical chemicals are as follows: 20 parts of radix aconiti lateralis preparata, rhizoma zingiberis 6 Part, 5 parts of Radix Glycyrrhizae, 20 parts of Radix Astragali, 20 parts of Radix Codonopsis, 9 parts of Radix Ophiopogonis, 4 parts of Schisandra chinensis, 6 parts of ramulus cinnamomi, 20 parts of raw oyster.
5. Chinese medicine composition according to claim 2, it is characterised in that the proportion of each bulk pharmaceutical chemicals are as follows: 25 parts of radix aconiti lateralis preparata, rhizoma zingiberis 8 Part, 8 parts of Radix Glycyrrhizae, 25 parts of Radix Astragali, 25 parts of Radix Codonopsis, 10 parts of Radix Ophiopogonis, 5 parts of Schisandra chinensis, 8 parts of ramulus cinnamomi, 25 parts of raw oyster.
6. Chinese medicine composition described in any one of claims 1 to 5, it is characterised in that further include in following flavour of a drug in bulk pharmaceutical chemicals Any combination more than any taste or two tastes: 6-15 parts of Radix Paeoniae Alba, 3-10 parts of Cortex Magnoliae Officinalis, 10-15 parts of radix rehmanniae recen, 3-10 parts of the dried immature fruit of citron orange.
7. Chinese medicine composition described in any one of claims 1 to 6 is in preparing the drug for treating dilated cardiomyopathy Using.
8. Chinese medicine composition described in any one of claims 1 to 6 is preparing the syndrome of yang deficiency and blood stasis for treating Chinese medicine distention related to the heart disease Drug in application.
CN201910288517.8A 2019-04-11 2019-04-11 Traditional Chinese medicine composition for treating dilated cardiomyopathy and application thereof Active CN109966461B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910288517.8A CN109966461B (en) 2019-04-11 2019-04-11 Traditional Chinese medicine composition for treating dilated cardiomyopathy and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910288517.8A CN109966461B (en) 2019-04-11 2019-04-11 Traditional Chinese medicine composition for treating dilated cardiomyopathy and application thereof

Publications (2)

Publication Number Publication Date
CN109966461A true CN109966461A (en) 2019-07-05
CN109966461B CN109966461B (en) 2021-08-10

Family

ID=67084049

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910288517.8A Active CN109966461B (en) 2019-04-11 2019-04-11 Traditional Chinese medicine composition for treating dilated cardiomyopathy and application thereof

Country Status (1)

Country Link
CN (1) CN109966461B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113750146A (en) * 2021-09-02 2021-12-07 吴绍伟 External application traditional Chinese medicine formula for treating cardiac hypertrophy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102048895A (en) * 2011-01-17 2011-05-11 王仁平 Pure traditional Chinese medicine preparation for treating dilated cardiomyopathy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102048895A (en) * 2011-01-17 2011-05-11 王仁平 Pure traditional Chinese medicine preparation for treating dilated cardiomyopathy

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
汪艳丽 等: "中西医结合对慢性心力衰竭患者生命质量的影响", 《中国中医药信息杂志》 *
白玉生 等: "中西医结合治疗扩张型心肌病疗效观察", 《中西医结合实用临床急救》 *
程继昆 等: "中药治疗扩张型心肌病25例", 《吉林中医药》 *
黄煌 等: "《名中医方药传真》", 30 September 2018 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113750146A (en) * 2021-09-02 2021-12-07 吴绍伟 External application traditional Chinese medicine formula for treating cardiac hypertrophy

Also Published As

Publication number Publication date
CN109966461B (en) 2021-08-10

Similar Documents

Publication Publication Date Title
CN101229312A (en) Medicine compounds capable of regulating hypertension, hyperlipemia and angina
CN104491342A (en) Medicament for treating diabetes and preparation method thereof
CN109966461A (en) A kind of Chinese medicine composition and its application for treating dilated cardiomyopathy
CN103191331B (en) Traditional Chinese medicine composition for treating bronchial asthma in remission stage
CN102526631B (en) Traditional Chinese medicine preparation, tablet and capsule for curing dilated cardiomyopathy and preparation method
CN104784670A (en) Pharmaceutical composition for treating myocarditis and preparation method of pharmaceutical composition
CN105055967B (en) A kind of complex health care product and preparation method with auxiliary hyperglycemic function
CN105833055A (en) Traditional Chinese medicine composition for treating hypertension, hyperlipidemia and hyperglycemia and preparing method and application thereof
CN105902897A (en) Pharmaceutical preparation for treating pancreatic cancer and application thereof
CN109758497A (en) For the Chinese medicine composition of chronic heart failure, drug and its preparation method and application
CN100558387C (en) The Chinese medicinal capsule of treatment heart failure
CN104383443A (en) Traditional Chinese medicine composition for treating arrhythmia
CN104277958A (en) Health wine for reducing blood sugar level
CN104857459B (en) A kind of Chinese medicine composition for treating heart failure and preparation method thereof
CN107126547A (en) A kind of Chinese medicine composition with antitumaous effect and preparation method thereof
CN103055299B (en) Traditional Chinese medicine composition for treating slow arrhythmia and preparation method thereof
CN102078367B (en) Use of aidi preparation in preparation of medicaments for treating multiple organ dysfunction syndrome in elderly
CN105535454A (en) Medicine for treating diastolic cardiac dysfunction
CN105106884B (en) Qi and activate blood circulation lets out turbid side
CN104189424A (en) Traditional Chinese medicine composition for treating heart failure
CN116036192A (en) Liver nourishing and fiber dissolving granule
CN105998842A (en) Traditional Chinese medicine preparation for treating cholecystitis due to qi stagnation and blood stasis
CN100333769C (en) Chinese herbal granule for treating viral myocarditis and its preparing process
CN104208570A (en) Traditional Chinese medicinal composition for treating heart failure, and preparation method thereof
CN102961680B (en) Traditional Chinese medicine preparation for treating gallstone and cholecystitis and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant