CN109966428B - Formula of nasopharynx traditional Chinese medicine flushing fluid - Google Patents
Formula of nasopharynx traditional Chinese medicine flushing fluid Download PDFInfo
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- CN109966428B CN109966428B CN201910349688.7A CN201910349688A CN109966428B CN 109966428 B CN109966428 B CN 109966428B CN 201910349688 A CN201910349688 A CN 201910349688A CN 109966428 B CN109966428 B CN 109966428B
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Abstract
The invention discloses a nasopharynx traditional Chinese medicine flushing fluid, which comprises the following raw material medicines in parts by weight: 1-3 parts of chrysanthemum, 1-3 parts of pogostemon cablin, 0.5-1.5 parts of liquorice, 0.5-1.5 parts of mint, 0.5-1.5 parts of scutellaria baicalensis, 1-3 parts of radix pseudostellariae, 2-10 parts of semen coicis, 1-3 parts of gardenia, 3-7 parts of oldenlandia diffusa, 3-7 parts of ternate buttercup root, 2-5 parts of astragalus membranaceus, 1-10 parts of spina gleditsiae and 0.5-1.5 parts of trichosanthes root. The nasopharynx traditional Chinese medicine flushing liquid has a physical or mechanical cleaning effect, can reduce inflammatory factors, can obviously reduce nasopharynx mucous membrane edema, improves the immunity state of the nasopharynx mucous membrane and improves the function of the nasopharynx mucous membrane, and is beneficial to recovering the nasopharynx function.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a nasopharynx traditional Chinese medicine flushing fluid formula.
Background
Nasopharynx is a respiratory tract portal, and due to aggravation of air pollution in the environment, a large amount of dust and smoke are inhaled through the nose, and then the nose is high in disease, such as nasosinusitis, allergic rhinitis and the like, secretion flows to the nasopharynx to cause nasopharynx discomfort, and nasopharynx dryness, more scabs and the like appear after radiotherapy of nasopharyngeal carcinoma, so that the health of a human body is seriously affected. The reason for discomfort of nasopharynx can be divided into two categories, one is through physical reasons such as dust, secretion and crusty skin to stay in nasopharynx, the other is through inflammation of nasopharynx mucous membrane caused by cell factor, infection and the like, and long-term nasopharyngitis in the south of five Ridges is also indirectly related to nasopharyngeal carcinoma. Thus, nasopharyngeal health is very important.
Lingnan is a high incidence area of nasopharyngeal carcinoma, and radiotherapy is the first choice for treatment of nasopharyngeal carcinoma. Radiation can effectively kill nasopharyngeal carcinoma cells, but still kill healthy tissues around the nasopharyngeal carcinoma, so that patients can have serious side effects. The nasopharynx mucous membrane can be dry, even atrophied, rich in secretion, sticky, even plugged by crust skin, foul smell and the like, inspection shows that the nasopharynx mucous membrane is congested, edematous and ulcerated, even has secondary infection and tissue necrosis, and part of patients can not tolerate the treatment and stop the radiotherapy. For such patients, it is necessary to administer a timely flush of the nasopharynx to remove nasopharynx secretions, keeping the nasopharynx clean and moist, while administering conventional treatments.
Disclosure of Invention
The invention aims to provide a nasopharynx traditional Chinese medicine washing liquid.
The invention also provides a use method of the nasopharynx traditional Chinese medicine irrigation solution.
The technical scheme adopted by the invention is as follows:
provides a nasopharynx traditional Chinese medicine flushing fluid, the active ingredients of which comprise the following raw material medicines in parts by weight: 1-3 parts of chrysanthemum, 1-3 parts of pogostemon cablin, 0.5-1.5 parts of liquorice, 0.5-1.5 parts of mint, 0.5-1.5 parts of scutellaria baicalensis, 1-3 parts of radix pseudostellariae, 2-10 parts of semen coicis, 1-3 parts of gardenia, 3-7 parts of oldenlandia diffusa, 3-7 parts of ternate buttercup root, 2-5 parts of astragalus membranaceus, 1-10 parts of spina gleditsiae and 0.5-1.5 parts of trichosanthes root.
Preferably, the active ingredients of the medicine comprise the following raw material medicines in parts by weight: 2 parts of chrysanthemum, 2 parts of patchouli, 1 part of liquorice, 1 part of mint, 1 part of scutellaria baicalensis, 2 parts of radix pseudostellariae, 3 parts of semen coicis, 2 parts of gardenia, 5 parts of oldenlandia diffusa, 2 parts of radix ranunculi ternati, 3 parts of astragalus mongholicus, 2 parts of spina gleditsiae and 1 part of trichosanthes root.
Further, the effective components of the mint and the patchouli are volatile oil of the mint and the patchouli, and are extracted by a steam distillation method to obtain the component A.
Further, the rest raw materials except the mint and the patchouli are decocted with water and precipitated with alcohol to obtain the component B, the component A, B is mixed, sterilized and the pH value and osmotic pressure of the nasopharyngeal wash are adjusted.
Preferably, the pH value of the nasopharynx traditional Chinese medicine flushing liquid is 7.0-7.5.
Preferably, the nasopharynx traditional Chinese medicine washing liquid is isotonic with 0.9-1.5% of normal saline.
The application method of the nasopharynx traditional Chinese medicine flushing fluid is provided, and the nasopharynx flushing fluid with the temperature of 35-37 ℃ is used for flushing the nasal cavity through a disposable sputum suction tube.
Preferably, the dosage of the nasopharynx washing liquid is 400-500 ml each time, and the nasopharynx washing liquid is washed 2-3 times a day.
The invention has the beneficial effects that:
1. the traditional Chinese medicine nasopharynx washing liquid has a physical or mechanical washing effect. The washing liquid enters from the anterior naris, flows through the posterior naris after infiltration, dilution and scrubbing, and then is discharged from the oral cavity, thereby achieving the effects of moistening and removing nasopharyngeal secretions, dust and crusts.
2. The traditional Chinese medicine nasopharynx flushing fluid can reduce inflammatory factors, can greatly thin secretion on the surface of nasopharynx mucous membrane, and enables the secretion to be easily discharged, thereby reducing adverse effects of the inflammatory factors.
3. The traditional Chinese medicine nasopharynx flushing liquid disclosed by the invention can be used for remarkably reducing nasopharynx mucous membrane edema, improving the immunity state and improving the function of nasopharynx mucous membranes and is beneficial to recovering the nasopharynx function.
Drawings
FIG. 1 shows the results of nasal endoscope before and after treatment with nasopharynx irrigating solution after radiotherapy for nasopharyngeal carcinoma patients. A: after radiotherapy, B: after the rinsing treatment.
FIG. 2 nasal endoscope results before and after nasopharynx irrigation fluid treatment after radiotherapy for nasopharyngeal carcinoma patients. A: after radiotherapy, B: after the rinsing treatment.
Detailed Description
The invention is further described with reference to the following detailed description of embodiments in conjunction with the accompanying drawings. The following examples are for illustrative purposes only and are not to be construed as limiting the invention. Unless otherwise specified, the raw materials used in the following examples, raw materials for reagents, were raw materials conventionally commercially available or commercially available. The apparatus used in the following examples is an apparatus conventionally used in the art unless otherwise specified.
The pharmacology of the raw material medicaments of the invention is as follows:
the formula adopts chrysanthemum to dispel wind and dredge orifices, clear heat and detoxify, and the chrysanthemum is named as chrysanthemum in Rihuazi materia Medica: promoting blood circulation, treating wind-wandering in limbs, carbuncle and headache. Oldenlandia, herba Hedyotidis Diffusae, QUANZHOU materia Medica, is used for clearing away heat and toxic materials, promoting blood circulation, and relieving swelling: clearing heat, removing blood stasis, eliminating carbuncle and removing toxicity. For carbuncle, deep-rooted carbuncle, sore and ulcer and scrofula, modern researches also find that oldenlandia has an inhibiting effect on various tumors. The two medicines are the monarch medicines together. Scutellaria baicalensis and cape jasmine for clearing heat and drying dampness, purging fire and removing toxicity, ternate buttercup root for reducing phlegm and resolving masses, removing toxicity and reducing swelling, spina gleditsiae for drawing out toxicity, reducing swelling and discharging pus, and is called spina gleditsiae in the book of materia medica: the rice vinegar is decocted to make the needle tender and decocted thickly, and the wound is applied to tinea to treat carbuncle swelling and sore toxin, the radices trichosanthis is used for clearing heat and promoting fluid, reducing swelling and expelling pus, and the medicaments are used as ministerial medicaments for detoxifying and removing putrefaction. Patchouli, mint and aromatic resuscitation inducing herbs, radix pseudostellariae, semen coicis and astragalus root are used as adjuvant drugs for supplementing qi and nourishing yin, and liquorice is used as a guiding drug for harmonizing the effects of the other drugs.
The traditional Chinese medicine has the functions of combining the medicines: aromatic resuscitation inducing, yin nourishing, salivation promoting, toxic materials clearing away, and putrefaction removing effects.
Example 1
A nasopharynx traditional Chinese medicine flushing fluid comprises the following raw material medicines in parts by weight as active ingredients: 2 parts of chrysanthemum, 2 parts of patchouli, 1 part of liquorice, 1 part of mint, 1 part of scutellaria baicalensis, 2 parts of radix pseudostellariae, 3 parts of semen coicis, 2 parts of gardenia, 5 parts of oldenlandia diffusa, 2 parts of radix ranunculi ternati, 3 parts of astragalus mongholicus, 2 parts of spina gleditsiae and 1 part of trichosanthes root.
Wherein, the mint and the patchouli which contain volatile oil are extracted by a steam distillation extraction method to keep the aromatic smell, other traditional Chinese medicines are decocted by a conventional traditional Chinese medicine water and alcohol precipitation method, the sterilization is carried out, the PH value is adjusted to be 7.0-7.5, and the isotonic with normal saline is adjusted to prepare the nasopharynx washing liquid.
Example 2
A nasopharynx traditional Chinese medicine flushing fluid comprises the following raw material medicines in parts by weight as active ingredients: 1 part of chrysanthemum, 1 part of patchouli, 1.5 parts of liquorice, 1.5 parts of mint, 0.5 part of scutellaria baicalensis, 1 part of radix pseudostellariae, 2 parts of semen coicis, 3 parts of gardenia, 7 parts of oldenlandia diffusa, 7 parts of radix ranunculi ternate, 2 parts of astragalus mongholicus, 10 parts of spina gleditsiae and 1.5 parts of trichosanthes root.
Wherein, the mint and the patchouli which contain volatile oil are extracted by a steam distillation extraction method to keep the aromatic smell, other traditional Chinese medicines are decocted by a conventional traditional Chinese medicine water and alcohol precipitation method, the sterilization is carried out, the PH value is adjusted to be 7.0-7.5, and the isotonic with normal saline is adjusted to prepare the nasopharynx washing liquid.
Example 3
A nasopharynx traditional Chinese medicine flushing fluid comprises the following raw material medicines in parts by weight as active ingredients: 3 parts of flower, 3 parts of patchouli, 0.5 part of liquorice, 0.5 part of mint, 1.5 parts of scutellaria baicalensis, 3 parts of radix pseudostellariae, 10 parts of semen coicis, 1 part of gardenia, 3 parts of oldenlandia diffusa, 3 parts of radix ranunculi ternate, 5 parts of astragalus mongholicus, 1 part of spina gleditsiae and 0.5 part of trichosanthes root.
Wherein, the mint and the patchouli which contain volatile oil are extracted by a steam distillation extraction method to keep the aromatic smell, other traditional Chinese medicines are decocted by a conventional traditional Chinese medicine water and alcohol precipitation method, the sterilization is carried out, the PH value is adjusted to be 7.0-7.5, and the isotonic with normal saline is adjusted to prepare the nasopharynx washing liquid.
Example 4 curative Effect test of Chinese medicine nasopharyngeal wash
1. The source of the cases is: 60 nasopharyngeal carcinoma patients are diagnosed through nasopharynx biopsy pathology, are from traditional Chinese medicine institute in Zhongshan city of Guangdong, age is 45-68 years old, and are randomly divided into A, B groups, each group comprises 30 cases, A group comprises 20 cases of men and 10 cases of women, the average age is 51.4 years old, and the nasopharyngeal carcinoma stage is as follows: 5 cases in II phase, 20 cases in III phase and 5 cases in IV phase. 18 men and 12 women with an average age of 50.2 years, 6 nasopharyngeal carcinoma stages II, 19 nasopharyngeal carcinoma stages III and 5 nasopharyngeal carcinoma stages IV.
2. Inclusion and rejection criteria: inclusion criteria were: (1) the diagnosis of nasopharyngeal carcinoma is satisfied, and (2) the patient receives conventional radiotherapy and nasopharynx irrigation.
Rejection standard: (1) the whole course of the treatment is completed for nasopharyngeal carcinoma. (2) Do not want to join the research cohort. (3) Those < 18 years of age or > 70 years of age.
3. The treatment method comprises the following steps: the two groups are treated by linear accelerator and three-dimensional adaptive intensity-modulated radiation, and the radiation dose is 70Gy of nasopharyngeal primary focus. The radiotherapy is generally completed in 2 months, patients with nasopharyngeal carcinoma all carry out nasopharyngeal irrigation, the patients with nasopharyngeal carcinoma who carry out nasopharyngeal irrigation by using the traditional Chinese medicine formula after the nasopharyngeal carcinoma radiotherapy are taken as group A, and the patients with nasopharyngeal carcinoma who carry out nasopharyngeal irrigation by using normal saline are taken as group B.
The nasopharynx flushing method comprises the following steps: 500mL of Chinese medicinal liquid or raw buried saline is connected with a disposable sputum suction tube, the washing liquid is preferably 36 ℃, a patient is ordered to take a sitting position, the body slightly leans forward and lowers the head, mouth opening breathing is performed, and the patient is connected with a basin. The nasal cavity or the affected side, which is less unobstructed, is flushed first, and then the other side is flushed. The frequency of washing is 3 times per day during radiotherapy, and is respectively in the morning, noon and half an hour before sleep.
4. Observation indexes and inspection methods:
(1) mucosal response standard: level 0: the mucous membrane is normal and has no congestion and red swelling; level 1: congestion, mild pain; and 2, stage: congestion and redness and swelling of mucous membrane, or secretion, moderate pain; and 3, level: severe congestion or exudation of mucous membranes, severe pain; 4, level: ulceration of the mucosa, bleeding, necrosis, severe pain.
(2) Tumor necrosis factor (TNF- α), all cases were examined by blood draw before and after treatment, and TNF- α kits were purchased from shanghai constant distance biotechnology limited, cat #: e-10110.
TNF- α assay: ELISA method detection, according to the kit instruction operation, the experimental apparatus includes: an enzyme-labeling instrument: finland (LabsystemsMultiskan MS): the instrument model is as follows: type 352; washing the plate machine: finland (Thermo Labsystems): the instrument model is as follows: AC 8; a centrifuge: micro high-speed centrifuge (homemade): the instrument model is as follows: TG 16W; an incubator: water-proof constant temperature incubator (made in China): the instrument model is as follows: GNP-9080 type.
4. The curative effect is as follows: and evaluating the curative effect when the radiotherapy of the patient is finished.
(1) The curative effects of radiotherapy and nasopharyngeal wash of nasopharyngeal mucosa of two groups of nasopharyngeal carcinoma patients are compared:
during the radiotherapy period, the nasopharyngeal mucosa reactions of two groups of patients are light, mostly 1 grade and 2 grade, and no 3 grade or 4 grade severe nasopharyngeal mucosa reactions occur. Group A: the proportion of nasopharyngeal mucosa reactions appearing in grade 1 and grade 2 is 36.4% and 63.6% respectively; group B: the proportion of nasopharyngeal mucosa reaction appearing in the 1-grade and the 2-grade is 28.2 percent and 81.8 percent respectively; the grade 2 reaction rate of the group B is obviously higher than that of the group A, P is less than 0.05, and the statistical result is shown in table 1.
TABLE 1 nasopharyngeal mucosa reaction after treatment of two groups of nasopharyngeal carcinoma patients
The results show that the mucosa reaction of patients who take nasopharynx washing with the traditional Chinese medicine formula after the radiotherapy of the nasopharynx cancer is obviously lighter than that of the patients who take the nasopharynx washing with the normal saline, and the statistical analysis shows that the difference is significant, and P is less than 0.05.
(2) TNF-alpha change before and after treatment of two groups of nasopharyngeal carcinoma patients
TNF-alpha is an important cytokine, is mainly produced by monocytes and macrophages, is related to tumors, inflammations and the like, is increased in two groups of nasopharyngeal carcinoma patients, and is reduced in different degrees after treatment (radiotherapy). However, the TNF-alpha in group A is reduced more obviously, the curative effect is obviously better than that in group B, the difference is significant, P is less than 0.05, and the statistical result is shown in table 2.
TABLE 2 TNF- α (ng/L) before and after treatment of two groups of nasopharyngeal carcinoma patients
EXAMPLE 5 exemplary cases
Case 1: liangguxx, male, 51 years old, Guangdong Zhongshan City, with bloody nasal discharge and swollen left cervical lymph node for 3 months, nasopharyngeal endoscopy shows nasopharyngeal lump, after biopsy, nasopharyngeal carcinoma is confirmed, and nasopharyngeal carcinoma MR and cervical lymph full body color ultrasound examination are performed to diagnose nasopharyngeal carcinoma stage 3. When the conventional radiotherapy and chemotherapy is performed, the patient has the symptoms of sticky phlegm, nasal obstruction and dry throat. As shown in FIG. 1A, the nasopharyngeal lump disappeared but the nasopharyngeal mucosa was congested and edema and there were many secretions on the surface. A red tongue with yellow and greasy coating and a thready and rapid pulse. Namely, nasopharynx washing liquid is used for washing nasopharynx, 3 times a day, 300ml each time, after 15 days of continuous washing, the sticky yellow sputum of the nasopharynx of a patient is obviously reduced, and nasal obstruction and dry and sore throat are obviously improved. Endoscopic examination shows that congestion and red swelling of nasopharyngeal mucosa are obviously relieved, and secretion disappears. See fig. 1B.
Case 2: li xxx, male, 31 years old, Zhongshan Guangdong, were diagnosed by sputum flowing backwards towards the nasopharynx for 3 months. As shown in FIG. 2A, nasopharyngeal endoscopy shows that nasopharyngeal mucosa is congested and edematous, has more secretion on the surface, no neoplasms in nasopharynx, no lymphadenectasis in neck, and blood EB virus examination is negative. The tongue is slightly red, the coating is greasy, the pulse is thready and rapid, and chronic nasopharyngitis is diagnosed. The nasopharynx is flushed with nasopharynx flushing liquid 3 times a day, 200ml each time, after 10 days of continuous flushing, the lumen of the nasopharynx sputum of a patient is obviously reduced, and the nasopharynx mucosa is free of congestion, red and swelling and the secretion disappears as shown by endoscopy. See FIG. 2B
Results of two groups of patients before and after treatment show that after treatment by the nasopharynx traditional Chinese medicine flushing liquid, nasopharynx secretion is obviously reduced, and nasopharynx red swelling and congestion are also obviously relieved.
Claims (6)
1. A nasopharynx traditional Chinese medicine flushing liquid is characterized by being prepared from the following raw material medicines in parts by weight: 1-3 parts of chrysanthemum, 1-3 parts of pogostemon cablin, 0.5-1.5 parts of liquorice, 0.5-1.5 parts of mint, 0.5-1.5 parts of scutellaria baicalensis, 1-3 parts of radix pseudostellariae, 2-10 parts of semen coicis, 1-3 parts of gardenia, 3-7 parts of oldenlandia diffusa, 3-7 parts of ternate buttercup root, 2-5 parts of astragalus membranaceus, 1-10 parts of spina gleditsiae and 0.5-1.5 parts of trichosanthes root.
2. The nasopharynx traditional Chinese medicine irrigation solution as claimed in claim 1, which is prepared from the following raw material medicines in parts by weight: 2 parts of chrysanthemum, 2 parts of patchouli, 1 part of liquorice, 1 part of mint, 1 part of scutellaria baicalensis, 2 parts of radix pseudostellariae, 3 parts of semen coicis, 2 parts of gardenia, 5 parts of oldenlandia diffusa, 2 parts of radix ranunculi ternati, 3 parts of astragalus mongholicus, 2 parts of spina gleditsiae and 1 part of trichosanthes root.
3. A nasopharyngeal washing liquid according to any one of claims 1 or 2, wherein the effective ingredients of the mint and the patchouli are volatile oils thereof, and the component A is obtained by extracting the volatile oils by steam distillation.
4. The nasopharyngeal wash according to claim 3, wherein the remaining raw materials except for the mint and the patchouli are decocted with water and precipitated with ethanol to obtain component B, which is prepared by mixing A, B, sterilizing, and adjusting the pH and osmotic pressure of the nasopharyngeal wash.
5. The nasopharyngeal traditional Chinese medicine washing liquid according to claim 4, wherein the pH value of the nasopharyngeal traditional Chinese medicine washing liquid is 7.0-7.5.
6. The nasopharyngeal traditional Chinese medicine irrigation solution according to claim 4, wherein said nasopharyngeal traditional Chinese medicine irrigation solution is isotonic with normal saline.
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