CN109966377A - A kind of externally applied drug - Google Patents

A kind of externally applied drug Download PDF

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Publication number
CN109966377A
CN109966377A CN201910364339.2A CN201910364339A CN109966377A CN 109966377 A CN109966377 A CN 109966377A CN 201910364339 A CN201910364339 A CN 201910364339A CN 109966377 A CN109966377 A CN 109966377A
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parts
externally applied
applied drug
grams
filtrate
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CN201910364339.2A
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Chinese (zh)
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李国伦
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A61K36/855—Clerodendrum, e.g. glorybower
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides a kind of externally applied drug, it is characterised in that is made of the raw material of following mass parts: 25~40 parts of lycopod, 15~35 parts of climbing groundsel, 20~40 parts of Chinese coriaria leaf, 15~30 parts of Radix Angelicae Pubescentis, 15~30 parts of clerodendrum bungei.With dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, clearing heat and detoxicating, anti-inflammatory, antipruritic, swelling and pain relieving, arthritis analgesic, promoting blood circulation to remove blood stasis, subdhing swelling and detoxicating and other effects, there is significant therapeutic effect to traumatic injury bone, osteoarthrosis pain, skin disease, tinea pedis, and restore fast, recurrence rate is low, it is highly-safe, have no toxic side effect, while it is easy to make.

Description

A kind of externally applied drug
Technical field
The present invention relates to a kind of externally applied drug, especially it is a kind of treat traumatic injury, osteoarthrosis pain, skin disease, tinea pedis it is outer Medication belongs to biomedicine technical field.
Background technique
Traumatic injury: refer to people because of the soft tissue injury caused by the reasons such as falling, beating, touch, knock, be mainly shown as red and swollen, swollen Bitterly.
Osteoarthrosis pain: the pain caused by the wounds such as ligament injury, soft tissue injury, redness, inflammation and joint mostly Synovitis etc. causes and with symptoms such as activity is blocked, function limitations.Less serious case can due to pain influence activity withSleep, severe one meeting Work and life are influenced, causes the disease of osteoarthrosis pain above, it may occur that in knee, shoulder, elbow, wrist, ankle-joint or refer to, toe joint Pain and inconvenience are brought to patient in equal positions.
Skin disease: skin disease is the general name occurred in skin and skin accessory organ's disease.Skin is the maximum device of human body Official, it is dermopathic many kinds of, such as the skin disease because of caused by leprosy, scabies, fungi, bacterial skin infections, some skin diseases It is also accompanied by certain infectiousness, not only influences health, and social fear can be caused.
Tinea pedis: being that fungal infection causes, and skin lesion is often that first unilateral (i.e. single foot) occurs, meeting after several weeks or several months It infects to the other side.Blister mainly appears on toe abdomen and toe side, is common between three or four toes, and vola also may occur in which, mostly phlysis, Bleb can be gradually fused into.The skin lesion of tinea pedis has a feature, i.e. clear border, can gradually extend to the outside.Because of progression of the disease Or scratching, it may occur in which erosion, sepage, warts etc..
Treatment to above-mentioned disease, current drug are only capable for the treatment of a kind of or two kinds of illnesss, it is difficult to can to above-mentioned illness It is treated.
Summary of the invention
To solve the above problems, the present invention provides a kind of external application for treating traumatic injury, osteoarthrosis pain, skin disease, tinea pedis Medicine.
The present invention is realized by following technical proposal: a kind of externally applied drug is made of the raw material of following mass parts:
25~40 parts of lycopod, 15~35 parts of climbing groundsel, 20~40 parts of Chinese coriaria leaf, 15~30 parts of Radix Angelicae Pubescentis, 15~30 parts of clerodendrum bungei.
In the present invention:
Lycopod: nature and flavor: slight bitter, pungent, warm；Function: dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, analgesic.
Climbing groundsel: nature and flavor: bitter, cold；Function: clearing heat and detoxicating, anti-inflammatory, it is antipruritic.
Chinese coriaria leaf: nature and flavor: bitter, acrid, cold；Function: clearing heat and detoxicating, swelling and pain relieving.
Radix Angelicae Pubescentis: nature and flavor: bitter, pungent, tepor；Function: dispelling wind and eliminating dampness, arthritis analgesic.
Clerodendrum bungei: nature and flavor: pungent, warm；Function: promoting blood circulation to remove blood stasis, subdhing swelling and detoxicating.
The pharmacological action of externally applied drug provided by the invention: lycopod has effects that dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, analgesic；Thousand In light have clearing heat and detoxicating, anti-inflammatory, antipruritic effect；Chinese coriaria leaf has effects that clearing heat and detoxicating, swelling and pain relieving；Radix Angelicae Pubescentis, which has, dispels The effect of wind dehumidifying, arthritis analgesic；Clerodendrum bungei has effects that promoting blood circulation to remove blood stasis, subdhing swelling and detoxicating；The reasonably combined and phase of five kinds of Chinese medicine Mutually synergistic effect enables drug of the invention to have apparent treatment effect to traumatic injury, osteoarthrosis pain, skin disease, tinea pedis Fruit.
Said medicine provided by the invention follows these steps to prepare:
A1, it stocks up by following parts by weight: 25~40 parts of lycopod, 15~35 parts of climbing groundsel, 20~40 parts of Chinese coriaria leaf, Radix Angelicae Pubescentis 15~30 Part, 15~30 parts of clerodendrum bungei；
B1, by after the standby each bulk pharmaceutical chemicals removal impurity of A1 step institute, be separated by filtration through conventional medical after alcoholic extraction, then through conventional Filtrate and filter residue out abandon filter residue, and filtrate is externally applied drug.
Said medicine provided by the invention follows these steps to prepare:
A2, it stocks up by following parts by weight: 25~40 parts of lycopod, 15~35 parts of climbing groundsel, 20~40 parts of Chinese coriaria leaf, Radix Angelicae Pubescentis 15~30 Part, 15~30 parts of clerodendrum bungei；
B2, it after the standby each bulk pharmaceutical chemicals of A2 step institute are removed impurity, is directly placed into 50 ° or more of 1000 parts of edible wines, impregnates 15 Day or more, filtrate and filter residue are filtered to isolate, abandons filter residue, filtrate is externally applied drug.
In use, externally applied drug obtained by step B is applied directly to affected part or is soaked in hospital gauze or medical non-woven fabrics Or on medical paper handkerchief, spread on affected part, wrap up coating or topical application of drug affected part 1-2 hour with preservative film, one day it is most twice, medication After can have obvious therapeutic effect.
The effect and advantage that the present invention has: the treatment traumatic injury that obtains by adopting the above technical scheme, osteoarthrosis pain, skin The externally applied drug of skin disease, tinea pedis, relieved pain with dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, clearing heat and detoxicating, anti-inflammatory, antipruritic, swelling and pain relieving, arthritis, Promoting blood circulation to remove blood stasis, subdhing swelling and detoxicating and other effects have significant therapeutic effect to traumatic injury bone, osteoarthrosis pain, skin disease, tinea pedis, and Restore fast, recurrence rate is low, it is highly-safe, have no toxic side effect, while it is easy to make.
Specific embodiment
The present invention will be further described combined with specific embodiments below.
Above content of the invention is described in detail in specific implementation method by the following examples.But it should not be by this It is interpreted as above content of the present invention and is only limitted to embodiment below.All technologies realized based on above content of the present invention are belonged to The scope of the present invention.
Embodiment 1
A, by the material preparation of following mass parts:
25 grams of lycopod, 15 grams of climbing groundsel, 20 grams of Chinese coriaria leaf, 15 grams of Radix Angelicae Pubescentis, 15 grams of clerodendrum bungei；
B, it by after the standby each bulk pharmaceutical chemicals removal impurity of step A institute, is directly placed into 1000 grams of medical grade alcohol and impregnates 15, filtering point Filtrate and filter residue are separated out, filter residue is abandoned；
C, filtrate obtained by step B is externally applied drug.
Embodiment 2
A, by the material preparation of following mass parts:
40 grams of lycopod, 35 grams of climbing groundsel, 40 grams of Chinese coriaria leaf, 30 grams of Radix Angelicae Pubescentis, 30 grams of clerodendrum bungei；
B, 55 ° will be directly placed into, will be impregnated 25 in 1000 grams of corn wines, filtering divides after the standby each bulk pharmaceutical chemicals removal impurity of step A institute Filtrate and filter residue are separated out, the filter residue is abandoned；
C, filtrate obtained by step B is externally applied drug.
Embodiment 3
A, by the material preparation of following mass parts:
30 grams of lycopod, 25 grams of climbing groundsel, 30 grams of Chinese coriaria leaf, 20 grams of Radix Angelicae Pubescentis, 20 grams of clerodendrum bungei；
B, 65 ° will be directly placed into, will be impregnated 20 in 1000 grams of kaoliang spirits, filtering divides after the standby each bulk pharmaceutical chemicals removal impurity of step A institute Filtrate and filter residue are separated out, the filter residue is abandoned；
C, filtrate obtained by step B is externally applied drug.
Embodiment 4
A, by the material preparation of following mass parts:
26 grams of lycopod, 35 grams of climbing groundsel, 22 grams of Chinese coriaria leaf, 16 grams of Radix Angelicae Pubescentis, 28 grams of clerodendrum bungei；
B, 58 ° will be directly placed into, will be impregnated 25 in 1000 grams of corn wines, filtering divides after the standby each bulk pharmaceutical chemicals removal impurity of step A institute Filtrate and filter residue are separated out, the filter residue is abandoned；
C, filtrate obtained by step B is externally applied drug.
Embodiment 5
A, by the material preparation of following mass parts:
36 grams of lycopod, 18 grams of climbing groundsel, 36 grams of Chinese coriaria leaf, 20 grams of Radix Angelicae Pubescentis, 18 grams of clerodendrum bungei；
B, 59 ° will be directly placed into, will be impregnated 30 in 1000 grams of kaoliang spirits, filtering divides after the standby each bulk pharmaceutical chemicals removal impurity of step A institute Filtrate and filter residue are separated out, the filter residue is abandoned；
C, filtrate obtained by step B is externally applied drug.
By the resulting externally applied drug of above-described embodiment 1, treated for following clinical:
One, treatment object
Selection traumatic injury case 60, is randomly divided into treatment group and control group each 30.
Two, treatment method
The filtrate of the embodiment of the present invention 1 is embrocated by treatment group, wraps up coating affected part 2 hours with preservative film, and 15 grams every time, 2 times a day, It is used in conjunction 1 week.
Control group routinely embrocates the ZHENGHONGHUA YOU of conventional therapy traumatic injury, is used in conjunction 1 week.
Three, result
Externally applied drug provided by the invention is to the efficient up to 100%, obvious effective rate 87%, clinical cure rate 77% of traumatic injury；And Control group is to the efficient up to 52% of traumatic injury.
Externally applied drug obtained by above-described embodiment 1-4 is taken, is treated for following clinical:
One, treatment object
Selection treating rheumatic ostealgia 35, arthralgia 35, cervical vertebra pain 35, pain in the loins 35.
Above-mentioned all kinds of cases are bisected into four treatment groups (every group 30) and one control group 20 at random.
Two, usage
Four treatment groups respectively soak externally applied drug obtained by embodiment 1-4 on hospital gauze, and infusion medicine yarn cloth is spread on affected part, use Preservative film wraps up topical application of drug affected part 1 hour, 2 times a day, 25 grams every time, is used in conjunction 2 weeks.
Control group uses the Yunnan Baiyao of conventional therapy osteoarthrosis pain, is used in conjunction 2 weeks.
Three, result
Externally applied drug provided by the invention is to the efficient up to 100%, obvious effective rate 86%, clinical cure rate 73% for the treatment of rheumatic ostealgia；To joint Pain it is efficient up to 100%, obvious effective rate 85%, clinical cure rate 75%；To cervical vertebra pain effective percentage up to 100%, obvious effective rate 87%, face Bed cure rate 74%；To the efficient up to 100%, obvious effective rate 83%, clinical cure rate 77% of pain in the loins.
And control group is to the efficient up to 49% for the treatment of rheumatic ostealgia；To arthralgic efficient up to 43%；To the effective of lumbar vertebra pain Rate is up to 37%；To the efficient up to 51% of pain in the loins.
Externally applied drug obtained by above-described embodiment 3-5 is taken, is treated for following clinical:
One, treatment object
Select jock itch case 40, tinea pedis case 40, psoriasis example 40.
Above-mentioned all kinds of cases are bisected into three treatment groups (every group 30) and one control group 30 at random.
Two, usage
Externally applied drug obtained by embodiment 3-5 is embrocated respectively by three treatment groups, wraps up coating affected part 2 hours with preservative film, and 10 grams every time, 2 times a day, it is used in conjunction 2 weeks.
Control group is used in conjunction 2 weeks using the drug Da Kening of conventional therapy skin disease and tinea pedis.
Three, result
Externally applied drug provided by the invention is to the efficient up to 100%, obvious effective rate 88%, cure rate 80% of tinea pedis and manus；To the effective of tinea pedis Rate is up to 100%, obvious effective rate 89%, cure rate 83%；The efficient up to 100%, obvious effective rate 80%, cure rate 72% of disease is cut to silver.
And control group is to the efficient up to 60% of tinea pedis and manus；To the efficient up to 65% of tinea pedis；The effective percentage for cutting disease to silver reaches 35%。
Four, conclusion
The ingredient of externally applied drug provided by the invention is all Chinese herbal medicine, does not have a toxic side effect to human body, then by medical grade ethyl alcohol or Edible wine impregnates, and activates herbal nature, human body corresponding site is acted on, thus to traumatic injury, osteoarthrosis pain, skin disease, foot Discomfort caused by tinea has the function of rapid recovery and treatment, small with medicinal application safety, toxic side effect, significant in efficacy, without after Disease is lost, not recurrent exerbation, securely and reliably.

Claims (3)

1. a kind of externally applied drug, it is characterised in that be made of the raw material of following mass parts:
25~40 parts of lycopod, 15~35 parts of climbing groundsel, 20~40 parts of Chinese coriaria leaf, 15~30 parts of Radix Angelicae Pubescentis, 15~30 parts of clerodendrum bungei.
2. a kind of externally applied drug as described in claim 1, it is characterised in that prepared by the following steps:
A, it stocks up by following parts by weight: 25~40 parts of lycopod, 15~35 parts of climbing groundsel, 20~40 parts of Chinese coriaria leaf, Radix Angelicae Pubescentis 15~30 Part, 15~30 parts of clerodendrum bungei；
B, it by after the standby each bulk pharmaceutical chemicals removal impurity of step A institute, is directly placed into 50 ° or more of 1000 parts of edible wines, impregnates 15 More than, filtrate and filter residue are filtered to isolate, abandons filter residue, filtrate is externally applied drug.
3. a kind of externally applied drug as described in claim 1, it is characterised in that prepared by the following steps:
A, it stocks up by following parts by weight: 25~40 parts of lycopod, 15~35 parts of climbing groundsel, 20~40 parts of Chinese coriaria leaf, Radix Angelicae Pubescentis 15~30 Part, 15~30 parts of clerodendrum bungei；
B, it by after the standby each bulk pharmaceutical chemicals removal impurity of step A institute, is filtered to isolate after conventional medical grade alcoholic extraction, then through conventional Filtrate and filter residue abandon filter residue, and filtrate is externally applied drug.
CN201910364339.2A 2019-04-30 2019-04-30 A kind of externally applied drug Pending CN109966377A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910364339.2A CN109966377A (en) 2019-04-30 2019-04-30 A kind of externally applied drug

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Application Number Priority Date Filing Date Title
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1895316A (en) * 2006-05-31 2007-01-17 王浩贵 Medicine for treating skin titillation, tinea pedis and beriberi
CN104873721A (en) * 2015-05-07 2015-09-02 刘海明 Bleeding-stopping pain-relieving paste

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1895316A (en) * 2006-05-31 2007-01-17 王浩贵 Medicine for treating skin titillation, tinea pedis and beriberi
CN104873721A (en) * 2015-05-07 2015-09-02 刘海明 Bleeding-stopping pain-relieving paste

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
朱可俭 主编: "《使用临床中药手册》", 31 December 2008 *

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Application publication date: 20190705

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