CN109966333A - A kind of plaster - Google Patents
A kind of plaster Download PDFInfo
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- CN109966333A CN109966333A CN201910337372.6A CN201910337372A CN109966333A CN 109966333 A CN109966333 A CN 109966333A CN 201910337372 A CN201910337372 A CN 201910337372A CN 109966333 A CN109966333 A CN 109966333A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Botany (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Insects & Arthropods (AREA)
- Zoology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Animal Husbandry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
A kind of plaster, it is characterized in that material medicine is 20~30 parts by weight of olibanum, 20~30 parts by weight of myrrh, 20~30 parts by weight of calamitas urinae hominis, 20~30 parts by weight of Chinese gall, 7~12 parts by weight of safflower；Iron pan is added after above-mentioned raw materials drug is crushed, after adding 20~60min of vinegar immersion of 800~1200 parts by weight, is spread evenly across on cotton after being boiled into paste to obtain the final product.
Description
Technical field
The present invention relates to one kind to stick class drug for external application.
Background technique
Traditional Chinese medicine thinks that promoting flow of qi and blood circulation stagnation resolvation is the principle of fractures.Chinese traditional treatment bone fracture mostly uses plaster, but
Traditional plaster can not play the role of fixed affected part, need separately to fix using such as gypsum mode, to affect the treatment.And it presses
Have the drug of promoting flow of qi and blood circulation stagnation resolvation effect numerous according to theory of traditional Chinese medical science, how preferably to go out most in the drug of existing set a broken bone
Suitable prescription, and the preparation process by improving plaster, can be more conducive to the healing of fracture, become the prior art
Middle urgent problem to be solved.
Summary of the invention
To solve aforementioned technical problem, the technical solution that we provide is:
A kind of plaster, material medicine are 20~30 parts by weight of olibanum, 20~30 parts by weight of myrrh, 20~30 weight of calamitas urinae hominis
Part, 20~30 parts by weight of Chinese gall, 7~12 parts by weight of safflower；Iron pan is added after above-mentioned raw materials drug is crushed, adds 800
After the vinegar of~1200 parts by weight impregnates 20~60min, it is spread evenly across on cotton after being boiled into paste to obtain the final product.
A kind of plaster, further, material medicine are 25 parts by weight of olibanum, and 25 parts by weight of myrrh, calamitas urinae hominis 25
Parts by weight, 25 parts by weight of Chinese gall, 10 parts by weight of safflower；Will above-mentioned raw materials drug crush after iron pan is added, add 800~
After the vinegar of 1200 parts by weight impregnates 25~40min, it is spread evenly across on cotton after being boiled into paste to obtain the final product.
Any plaster, further, it is 120 mesh medicinal powder that the material medicine, which crushes,.
Any plaster, further, soaking time of the material medicine powder in making vinegar is
25min~35min.
Any plaster, further, the vinegar are preferably adopted as day and found health-care vinegar.
Any plaster, further, the iron pan are casting iron pan.
Any plaster, further, the tanning process of the plaster are as follows: after the completion of immersion, heat iron pan
It boils to the making vinegar for impregnating material medicine, then is slowly heated and is brewed within 40~60 minutes paste, kept during tanning
Stirring avoids being burned.
A kind of plaster provided by the invention, the preferred special ratios in the existing Chinese medicine with promoting flow of qi and blood circulation stagnation resolvation
The medicinal materials such as olibanum, myrrh, calamitas urinae hominis, Chinese gall, and use be added vinegar impregnate after, with iron pan boil plaster production side
Method is found surprisingly that the raw medicinal material prescription of special ratios, and in conjunction with special plaster manufacture craft, obtained plaster has anti-inflammatory
The effect of relieving pain and activating blood circulation stagnation resolvation especially produces unexpected effect when for bone healings such as fracture, can promote
The quick healing of fracture, and plaster can be hardened when sticking 3 days or so, can play the role of being auxiliarily fixed, moreover it can be used to
Cervical spondylosis, prolapse of lumbar intervertebral disc, bulging, the external application application treatment of the diseases such as pulled muscle.In prescription screening it was found that this hair
Each component cooperates in bright plaster, and in conjunction with the plaster that special manufacture craft obtains, can be improved bone healing effect, reduce it
It is middle any one component, or using copper pot boil plaster, all can plaster treatment bone fracture effect decline.Secondly, using Tianjin
The health-care vinegar of Tian Li DULIU vinegar limited liability company, city production can further increase bone injury healing instead of common vinegar
While effect, the lotion quality of plaster is improved, the problems such as making plaster after curing, will not crack in validity period.
Specific embodiment
A kind of plaster provided by the invention, a kind of plaster, material medicine are that olibanum A weight is divided, myrrh B parts by weight, in people
White C parts by weight, Chinese gall D parts by weight, safflower E parts by weight；Above-mentioned raw materials drug is crushed for cast iron is added after 120 mesh medicinal powder
Pot is spread evenly across on cotton after being boiled into paste after adding the vinegar immersion 30min of F parts by weight to obtain the final product.
The tanning process of the plaster are as follows: after the completion of immersion, moderate heat heats iron pan to the brewing for impregnating material medicine and eats
Vinegar boiling, then mild fire are slowly heated 50 minutes and are brewed into paste, are kept stirring during tanning with scoop and avoid being burned.
The vinegar used is common vinegar (founding old vinegar in the day of Tianjin Tian Li DULIU vinegar Co., Ltd production) or health care
Vinegar (health-care vinegar of Tianjin Tian Li DULIU vinegar Co., Ltd production, hygienic food and health number (1997) the 174th)
Chinese gall, Chinese medicine name are Anacardiaceae plant Chinese sumac Rhuschinensis Mill. potanin sumac
Rhuspotaninii Maxim. or redpunjab sumac root RhuspunjabensisStew.var.sinica (Diels) Rehd.et
Wils. the insect gall on leaf.
Safflower, Chinese medicine name are the dry flower of compositae plant safflower Carthamustinctorius L..
Olibanum, Chinese medicine name.For olive subject plant Boswellia carterii BoswelliacarteriiBirdw. and congener
BoswelliabhaurdajianaBirdw. the resin of bark exudation
Myrrh, Chinese medicine name.For olive subject plant Chinese violet tree Commiphoramyrrha Engl. or Ha Didingshu
The dry resin of Commiphoramolmol Engl..
Calamitas urinae hominis, Chinese medicine name.For the solids of Hominidae healthy human urine's natural sedimentation.
Embodiment, the raw material of comparative example and proportion see the table below (unit: parts by weight)
| Number | A | B | C | D | E | F |
| Embodiment 1 | 25 | 25 | 25 | 25 | 10 | 950/ common vinegar |
| Embodiment 2 | 20 | 30 | 20 | 30 | 7 | 800/ common vinegar |
| Embodiment 3 | 30 | 20 | 30 | 20 | 12 | 1200/ common vinegar |
| Embodiment 4 | 25 | 25 | 25 | 25 | 10 | 960/ health-care vinegar |
| Comparative example 1 | 0 | 32.5 | 32.5 | 32.5 | 13 | 960/ health-care vinegar |
| Comparative example 2 | 32.5 | 0 | 32.5 | 32.5 | 13 | 960/ health-care vinegar |
| Comparative example 3 | 32.5 | 32.5 | 0 | 32.5 | 13 | 960/ health-care vinegar |
| Comparative example 4 | 32.5 | 32.5 | 32.5 | 0 | 13 | 960/ health-care vinegar |
| Comparative example 5 | 27.5 | 27.5 | 27.5 | 27.5 | 0 | 960/ health-care vinegar |
| Comparative example 6 | 25 | 25 | 25 | 25 | 10 | 960/ health-care vinegar/copper pot tanning |
Pharmacological Examples
Experimental animal is using the male 3 monthly age Japan large ear rabbits of health, weight 2kg ± 0.5kg.Every group 5
Experimental animal performed the operation cause it is double scratch bone middle section about 3mm, the defective fracture model as deep as pulp cavity,
Medication group is applied with the plaster of embodiment or comparative example, and all animal patterns are with fixed outside plaster splint, postoperative company
Continuous three days intramuscular injection penicillin, daily 400,000 IU, once a day.
Medication are as follows: by the plaster being coated on cotton around scratch bone be applied with fracture (away from operation interface 0.5cm with
Do not have to inside), external application plaster splint is fixed, and blank group only gives fixed outside plaster splint.
After administration 7 days, experimental animal is put to death, bone side position X-ray is scratched in shooting under similarity condition, using Lane-
SandhuX ray standards of grading, which observe to X-ray, to be compared and scores, and standards of grading include three aspects, and the new bone in defective region is raw
At area ratio, defect boundary line clarity and bone plasticity.Defective region New born formation the area ratio: it is bone-free to organize the formation of, 0 point；New bone
The area ratio 25% is generated, is 1 point, New born formation the area ratio 50% is 2 points, and New born formation the area ratio 75% is 3 points, and new bone is raw
It is 4 points at the area ratio 100%；Defect boundary line is evident as 0 point, and obscurity boundary is 1 point, and it is 2 points that boundary, which disappears,；Without ossis
Be formed as 0 point, ossis is formed as 2 points, and cortex bone is formed as 4 points.The sum of each item rating is overall score.To the overall score of each group
Data are handled with EXCEL software, are indicated in a manner of mean ± standard deviation (means ± s).Simultaneously after observation experiment
The ordinary circumstance of plaster
Grouping and administrations and scoring (means ± s, n=10)
| Number | Administration | Scoring | Plaster |
| Experimental group 1 | Embodiment 1 | 3.3±0.48 | Hardening, there is breakage |
| Experimental group 2 | Embodiment 2 | 3.1±0.32 | Hardening, there is breakage |
| Experimental group 3 | Embodiment 3 | 3.2±0.42 | Hardening, there is breakage |
| Experimental group 4 | Embodiment 4 | 3.8±0.63 | Hardening, no breakage |
| Experimental group 5 | Comparative example 1 | 2.4±0.52 | Badly broken |
| Experimental group 6 | Comparative example 2 | 2.3±0.48 | Badly broken |
| Experimental group 7 | Comparative example 3 | 2.1±0.32 | Hardening, there is breakage |
| Experimental group 8 | Comparative example 4 | 2.2±0.42 | Hardening, there is breakage |
| Experimental group 9 | Comparative example 5 | 2.3±0.48 | Hardening, there is breakage |
| Experimental group 10 | Comparative example 6 | 2.6±0.52 | Hardening, there is breakage |
| Control group | Nothing | 1.3±0.48 |
The result shows that being apparently higher than blank control group using its union of each test group of animals of embodiment plaster scoring
It scores using the experimental group 4 of 4 plaster of embodiment also above experiment and in each experimental group with the experimental group using comparative example
Group 1~3 shows the effect for preferably promoting bone injury healing.In addition, only in experimental group 4, plaster in application after-hardening but
Without breakage, it can play the role of being auxiliarily fixed and the long period keeps good working condition on limbs.
Claims (7)
1. a kind of plaster, it is characterized in that material medicine is 20~30 parts by weight of olibanum, 20~30 parts by weight of myrrh, calamitas urinae hominis 20~
30 parts by weight, 20~30 parts by weight of Chinese gall, 7~12 parts by weight of safflower；Will above-mentioned raw materials drug crush after be added iron pan, then plus
After the 20~60min of vinegar immersion for entering 800~1200 parts by weight, it is spread evenly across on cotton after being boiled into paste to obtain the final product.
2. a kind of plaster as described in claim 1, material medicine are 25 parts by weight of olibanum, 25 parts by weight of myrrh, calamitas urinae hominis 25
Parts by weight, 25 parts by weight of Chinese gall, 10 parts by weight of safflower；Will above-mentioned raw materials drug crush after iron pan is added, add 800~
After the vinegar of 1200 parts by weight impregnates 25~40min, it is spread evenly across on cotton after being boiled into paste to obtain the final product.
3. a kind of plaster as claimed in claim 1 or 2, it is characterized in that it is 120 mesh medicinal powder that the material medicine, which crushes,.
4. a kind of plaster as claimed in claim 1 or 2, it is characterized in that soaking time of the material medicine powder in making vinegar
For 25min~35min.
5. a kind of plaster as claimed in claim 1 or 2, it is characterized in that the vinegar, which is preferably adopted as day, founds health-care vinegar.
6. a kind of plaster as claimed in claim 1 or 2, it is characterized in that the iron pan is casting iron pan.
7. a kind of plaster as claimed in claim 1 or 2, it is characterized in that the tanning process of the plaster are as follows: after the completion of immersion, add
Hot iron pot to the making vinegar for impregnating material medicine boils, then is slowly heated and is brewed within 40~60 minutes paste, boils process
In be kept stirring and avoid being burned.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910337372.6A CN109966333A (en) | 2019-04-25 | 2019-04-25 | A kind of plaster |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910337372.6A CN109966333A (en) | 2019-04-25 | 2019-04-25 | A kind of plaster |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109966333A true CN109966333A (en) | 2019-07-05 |
Family
ID=67086336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910337372.6A Pending CN109966333A (en) | 2019-04-25 | 2019-04-25 | A kind of plaster |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109966333A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101507784A (en) * | 2009-03-30 | 2009-08-19 | 孙建行 | Traditional Chinese medicine capable of promoting fracture healing |
| CN102416033A (en) * | 2011-12-06 | 2012-04-18 | 韩远乐 | Plaster for external use and preparation method thereof |
-
2019
- 2019-04-25 CN CN201910337372.6A patent/CN109966333A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101507784A (en) * | 2009-03-30 | 2009-08-19 | 孙建行 | Traditional Chinese medicine capable of promoting fracture healing |
| CN102416033A (en) * | 2011-12-06 | 2012-04-18 | 韩远乐 | Plaster for external use and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 卢梅生: "中草药促进骨折愈合的研究近况", 《新中医》 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
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Application publication date: 20190705 |