CN109953840A - Zero incisura anterior cervical interbody fusion cage of 3D printing - Google Patents
Zero incisura anterior cervical interbody fusion cage of 3D printing Download PDFInfo
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- CN109953840A CN109953840A CN201910271183.3A CN201910271183A CN109953840A CN 109953840 A CN109953840 A CN 109953840A CN 201910271183 A CN201910271183 A CN 201910271183A CN 109953840 A CN109953840 A CN 109953840A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30721—Accessories
- A61F2/30749—Fixation appliances for connecting prostheses to the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30772—Apertures or holes, e.g. of circular cross section
- A61F2002/30784—Plurality of holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30818—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves castellated or crenellated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2002/3093—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth for promoting ingrowth of bone tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Manufacturing & Machinery (AREA)
- Geometry (AREA)
- Physics & Mathematics (AREA)
- Prostheses (AREA)
Abstract
The present invention relates to a kind of backbone intervertebral implants, more particularly to a kind of zero incisura anterior cervical interbody fusion cage of 3D printing, including fusion device ontology and Self-locking screw, the fusion device ontology includes solid framework, porous structure is filled in solid framework, two perforative lock holes of inclination of setting, two Self-locking screws are reversely fixed in two lock holes on front side of the solid framework, and the solid framework and porous structure are all made of 3D printing technique and print.Fusion device ontology of the present invention selects the low bullet titanium alloy material of Ultra-fine Grained to be made into integration through 3D printing, solid framework and porous structure combine, it is good with target gap matching, it can effectively reduce the probability that dysphagia occurs in postoperative patient and Invasive lumbar fusion device sinks, fusion device ontology is fixed by Self-locking screw, provides good long-time stability, and it is small to be open when performing the operation, easy to operate, operating time is short, moderate.
Description
Technical field
The present invention relates to a kind of backbone intervertebral implants, and in particular to a kind of zero incisura anterior cervical vertebrae intervertebral fusion of 3D printing
Device.
Background technique
Spine interbody fusion is the important means for treating cervical vertebra and lumbar degenerative disease, the autologous bone transplanting of early stage because
High concurrent disease and gradually by clinic eliminate, Invasive lumbar fusion device appearance so that the success rate of the art formula greatly promotes.Currently, medical
Grade titanium alloy and the macromolecule polymeric material based on polyether-ether-ketone (PEEK) have become two big mainstream materials of fusion device manufacture
Material, still, macromolecule polymeric material can not provide sufficient space for cell adhesion, cannot have a common boundary well with Integrated implant around
Fibrous connective tissue is easily formed at face；It is also inferior to titanium alloy in terms of promoting osteoblast maturation and creating advantageous skeletonization environment,
Hinder its clinically further genralrlization and development.
In recent years, the 3D printing technique of hot spot has gradually incorporated the field of orthopaedics in medical instrument, 3D printing skill
The vesicular texture of art solves the wind that titanium alloy causes Invasive lumbar fusion device to sink because elasticity modulus is larger to a certain extent
Danger.Currently, a variety of zero incisura anterior cervical interbody fusion cage products such as PEEK PREVAIL, Zero-P, ROI-C it is American-European,
It is used widely on the ground such as Asia.Zero incisura anterior cervical interbody fusion cage of 3D printing also occurs gradually over domestic and international market.
But zero incisura anterior cervical interbody fusion cage majority is to inlay to combine with metal fixing plate with the main body of peek material in the market
Formula or the anterior cervical interbody fusion cage of titanium alloy 3D printing not can guarantee permanently effective stability without locking mechanism.
Chinese patent literature CN107753157A discloses a kind of cervical fusion cage, which is also using 3D
Printing technique manufacture, but the invention is not provided with locking mechanism, mobility is larger after surgery for cervical vertebra, only not by flank of tooth grooving
It can guarantee the slippage for preventing fusion device, need to fix by anterior plate fixation, and the incisura of steel plate is easy to oesophagus etc. and neck
The adjacent tissue of vertebra causes different degrees of compressing and influence, postoperative to be easy to cause the complication such as patient's dysphagia.
Summary of the invention
In order to solve the above technical problems, it is an object of the invention to: a kind of zero incisura anterior cervical vertebrae intervertebral of 3D printing is provided
Fusion device, it is possible to provide at once stable and long-term fixation improves bone grafting fusion or Bone Ingrowth rate, and postoperative patient appearance is effectively reduced
The probability that dysphagia and Invasive lumbar fusion device sink.
The present invention is technical solution used by solving its technical problem are as follows:
The zero incisura anterior cervical interbody fusion cage of 3D printing, including fusion device ontology and Self-locking screw, the fusion
Device ontology includes solid framework, porous structure is filled in solid framework, two inclinations of setting are perforative on front side of the solid framework
Lock hole, two Self-locking screws are reversely fixed in two lock holes, and the solid framework and porous structure are all made of 3D printing
Technology prints.
Fusion device ontology of the present invention is formed using 3D printing, and solid framework provides enough intensity, zero incisura for fusion device
Design reduces the risk of postoperative dysphagia, reduces the influence to soft tissue before centrum, and porous structure can effectively reduce titanium conjunction
Golden elasticity modulus of materials provides optimum structure for osteocyte migration and proliferation, can be not necessarily to bone grafting to reduce sedimentation risk.It adopts
Fusion device ontology is fixed with centrum with Self-locking screw, further increases implantation rear stability.Porous structure outer surface is coarse, has
Stick conducive to osteocyte, be proliferated and initial stability；Internal gutter is cross-linked with each other, and is convenient for bone cell proliferation, migration and vascularization
It is formed, maintains the steady in a long-term of Invasive lumbar fusion device, 70% or more porosity, X-ray can pass through most of region, be conducive to postoperative sight
It examines.
Wherein, preferred embodiment are as follows:
The reserved central bone grafting window in the porous structure centre, in the sufferer for needing bone grafting, using bone grafting fusion side
Formula achievees the purpose that interbody stabilizer and restores intervertebral height, and Bone Ingrowth can be promoted by being equipped with partially porous structure inside solid framework,
Improve initial stability.
The top and bottom of the fusion device ontology are equipped with pawl, it is possible to provide fix at once, prevent implantation material displacement from improving
Implantation position precision.
Using the low bullet titanium alloy material of Ultra-fine Grained, integrally printing is made the fusion device ontology, passes through the electron beam of 3D printing
Fusion technology provides out the solid framework and porous structure for sintering densification into of titanium alloy powder from level to level for growing into for bone
Put the environment of interconnection.The consistency of entity structure frame is up to 99.97%, and structural strength is suitable with forging titanium alloy, it is possible to provide
Enough fusion stability.The cross section of the fusion device ontology is the shape of a hoof, and fusion device ontology sagittal plane is set as raising upward
Cambered surface, shape of a hoof cross section is similar with nucleus pulposus original-shape, more preferably matches with centrum, is preferably bonded anatomical shape, can also
According to patient profiles' customizing print.
The porous structure is the porous network that interconnected microcellular structure is constituted, and aperture is 500-700 μm, hole
Rate is 70%-90%, and Bone Ingrowth demand can be met in this porosity ranges, is conducive to body fluid and transmits in implantation material, is permitted simultaneously
Perhaps bone tissue is grown into porous structure, forms biological fixation, improves the bond strength between implantation material-bone interface；Aperture is 500-
It 700 μm, both can guarantee the transport supported and supplied in osteogenetic process, and promoted the proliferation and maturation of osteoblast, and can guarantee ingrowth,
Guarantee the link stability at bone-implant interface.
Side window is set in the solid framework left end face and right end face, for reducing the overall stiffness of solid framework,
Prevent stress from covering, side window provides visualization on CT and X-ray.
Compared with prior art, the invention has the following advantages:
Fusion device ontology of the present invention selects low the bullets titanium alloy material of Ultra-fine Grained to be made into integration through 3D printing, solid framework with it is more
Pore structure combines, good with target gap matching, can effectively reduce postoperative patient and occurs under dysphagia and Invasive lumbar fusion device
Heavy probability, meanwhile, 3D printing technique can satisfy the individuation demand of different patients in conjunction with medical scanning, may customize implantation
Repairing effect is substantially improved in object.Fusion device ontology of the invention is fixed by Self-locking screw, is provided good initial stage and is fixed and grow
Phase stability, and while performing the operation, is open small, and easy to operate, operating time is short, moderate.
Detailed description of the invention
Fig. 1 is 1 three-dimensional structure diagram of the embodiment of the present invention.
Fig. 2 is 1 top view of the embodiment of the present invention.
Fig. 3 is 1 left view of the embodiment of the present invention.
Fig. 4 is Self-locking screw structural schematic diagram.
Fig. 5 is 2 top view of the embodiment of the present invention.
In figure: 1, porous structure；2, Self-locking screw；3, solid framework；4, locking screw thread；5, lock hole；7, pawl；8, side
Window；9, central bone grafting window.
Specific embodiment
The embodiment of the present invention is described further with reference to the accompanying drawing:
Embodiment 1:
As shown in Figs 1-4, zero incisura anterior cervical interbody fusion cage of 3D printing of the present invention, including fusion device ontology and
Self-locking screw 2, the fusion device ontology include solid framework 3, fill porous structure 1, the solid framework 3 in solid framework 3
Two perforative lock holes 5 of inclination are arranged in front side, and two Self-locking screws 2 are reversely fixed in two lock holes 5, the entity frame
Frame 3 and porous structure 1 are all made of 3D printing technique and print, and lock hole 5 is equipped with locking screw thread 4, and 2 tail portion of Self-locking screw is equipped with
Self-locking thread 4, Self-locking screw 3 are fixed fusion device and centrum by lock hole 5.
Wherein, the top and bottom of fusion device ontology are equipped with pawl 7, it is possible to provide fix at once, prevent implantation material displacement from mentioning
High implantation position precision；Using the low bullet titanium alloy material of Ultra-fine Grained, integrally printing is made fusion device ontology, passes through the electricity of 3D printing
Beamlet fusion technology, by the solid framework 3 and porous structure 1 for sintering densification into of titanium alloy powder from level to level.Solid framework
Consistency is up to 99.97%, and structural strength is suitable with forging titanium alloy, it is ensured that fusion stability；Porous structure 1 is mutually to interconnect
The porous network that logical microcellular structure is constituted, aperture are 500-700 μm, porosity 70%-90%, in this porosity ranges
Bone Ingrowth demand can be met, be conducive to body fluid and transmitted in implantation material, while bone tissue being allowed to grow into porous structure, form life
Object is fixed, and the bond strength between implantation material-bone interface is improved；Aperture is 500-700 μm, both can guarantee and has supported confession in osteogenetic process
Transport, promotes the proliferation and maturation of osteoblast, and can guarantee ingrowth, guarantees the link stability at bone-implant interface；
The cross section of fusion device ontology is the shape of a hoof, and fusion device ontology sagittal plane is set as the cambered surface to raise upward, shape of a hoof cross section with
Nucleus pulposus original-shape is similar, can more preferably match with centrum, preferably be bonded anatomical shape, can also be customized and be beaten according to patient profiles
Print；Side window 8 is arranged in 3 left end face of solid framework and right end face to be prevented from answering for reducing the overall stiffness of solid framework 3
Power shielding, side window 8 provide visualization on CT and X-ray.
Fusion device ontology of the present invention is formed using 3D printing, and solid framework 3 provides enough intensity, zero incisura for fusion device
Design reduces the risk of postoperative dysphagia, reduces the influence to soft tissue before centrum, porous structure 1 can effectively reduce bone grafting
Sedimentation risk, provide optimum structure for osteocyte migration and proliferation, bone grafting can be not necessarily to, using Self-locking screw 2 by fusion device sheet
Body is fixed with centrum, further increases implantation rear stability.1 outer surface of porous structure is coarse, is conducive to osteocyte and sticks, is proliferated
And initial stability；Internal gutter is cross-linked with each other, and is formed convenient for bone cell proliferation, migration and vascularization, maintains Invasive lumbar fusion device
Steady in a long-term, 70% or more porosity, X-ray can pass through most of region, is conducive to clinical follow.
Embodiment 2:
As shown in figure 5, the present invention is on the basis of embodiment 1, central bone grafting window 9 is reserved in 1 centre of porous structure,
Solid framework 3 can meet the needs of bearing capacity, and partially porous structure 1 can promote the rapid fusion of autologous bone, need bone grafting
In sufferer, interbody stabilizer is achieved the purpose that using bone grafting amalgamation mode and restores intervertebral height, is equipped with part inside solid framework 3
Porous structure 1 can promote Bone Ingrowth, improve initial stability.
Claims (8)
1. a kind of zero incisura anterior cervical interbody fusion cage of 3D printing, which is characterized in that including fusion device ontology and Self-locking screw
(2), the fusion device ontology includes solid framework (3), fills porous structure (1) in solid framework (3), the solid framework
(3) two perforative lock holes (5) of inclination of front side setting, two Self-locking screws (2) are reversely fixed in two lock holes (5),
The solid framework (3) and porous structure (1) are all made of 3D printing technique and print.
2. zero incisura anterior cervical interbody fusion cage of 3D printing according to claim 1, which is characterized in that the porous knot
The reserved central bone grafting window (9) in structure (1) centre.
3. zero incisura anterior cervical interbody fusion cage of 3D printing according to claim 1 or 2, which is characterized in that described to melt
The top and bottom of clutch ontology are equipped with pawl (7).
4. zero incisura anterior cervical interbody fusion cage of 3D printing according to claim 1, which is characterized in that the fusion device
Using the low bullet titanium alloy material of Ultra-fine Grained, integrally printing is made ontology.
5. zero incisura anterior cervical interbody fusion cage of 3D printing according to claim 1 or 3, which is characterized in that described to melt
The cross section of clutch ontology is the shape of a hoof.
6. zero incisura anterior cervical interbody fusion cage of 3D printing according to claim 1, which is characterized in that the entity frame
Side window (8) are set in frame (3) left end face and right end face.
7. zero incisura anterior cervical interbody fusion cage of 3D printing according to claim 1, which is characterized in that the fusion device
Ontology sagittal plane is set as the cambered surface to raise upward.
8. zero incisura anterior cervical interbody fusion cage of 3D printing according to claim 1, which is characterized in that the porous knot
Structure (1) is the porous network that interconnected microcellular structure is constituted, and aperture is 500-700 μm, porosity 70%-90%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910271183.3A CN109953840A (en) | 2019-04-04 | 2019-04-04 | Zero incisura anterior cervical interbody fusion cage of 3D printing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910271183.3A CN109953840A (en) | 2019-04-04 | 2019-04-04 | Zero incisura anterior cervical interbody fusion cage of 3D printing |
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| CN109953840A true CN109953840A (en) | 2019-07-02 |
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| CN201910271183.3A Pending CN109953840A (en) | 2019-04-04 | 2019-04-04 | Zero incisura anterior cervical interbody fusion cage of 3D printing |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111265347A (en) * | 2020-03-30 | 2020-06-12 | 广州华钛三维材料制造有限公司 | Intervertebral fusion cage |
| CN112402071A (en) * | 2019-08-23 | 2021-02-26 | 北京智塑健康科技有限公司 | Intervertebral fusion cage |
| CN112773577A (en) * | 2021-02-09 | 2021-05-11 | 北京爱康宜诚医疗器材有限公司 | Vertebral body prosthesis |
| CN112773578A (en) * | 2021-02-09 | 2021-05-11 | 北京爱康宜诚医疗器材有限公司 | Lumbar vertebra fusion cage |
| CN113040981A (en) * | 2021-02-08 | 2021-06-29 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | Polyether-ether-ketone artificial vertebral body |
| CN114886620A (en) * | 2022-04-27 | 2022-08-12 | 大连大学附属中山医院 | Biological tantalum metal knee joint prosthesis |
| CN116919679A (en) * | 2023-09-18 | 2023-10-24 | 吉林大学 | Personalized customization cervical vertebra zero-notch interbody fusion cage and manufacturing method |
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| CN106175999A (en) * | 2016-08-30 | 2016-12-07 | 蒋毅 | A kind of Invasive lumbar fusion device self-locking rock-steady structure |
| CN106580526A (en) * | 2017-01-12 | 2017-04-26 | 上海锐植医疗器械有限公司 | Cervical vertebral fusion cage |
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