CN109944762B - Four-channel binary high-pressure pump system of high-performance liquid chromatograph - Google Patents
Four-channel binary high-pressure pump system of high-performance liquid chromatograph Download PDFInfo
- Publication number
- CN109944762B CN109944762B CN201910305223.1A CN201910305223A CN109944762B CN 109944762 B CN109944762 B CN 109944762B CN 201910305223 A CN201910305223 A CN 201910305223A CN 109944762 B CN109944762 B CN 109944762B
- Authority
- CN
- China
- Prior art keywords
- inlet
- pump
- plunger rod
- outlet
- valve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 83
- 238000004140 cleaning Methods 0.000 claims abstract description 52
- 238000007789 sealing Methods 0.000 claims description 30
- 230000005540 biological transmission Effects 0.000 claims description 11
- 238000004891 communication Methods 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 230000000149 penetrating effect Effects 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 3
- 238000001802 infusion Methods 0.000 description 11
- 238000001514 detection method Methods 0.000 description 8
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000010295 mobile communication Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000337 buffer salt Substances 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Details Of Reciprocating Pumps (AREA)
Abstract
The invention discloses a four-channel binary high-pressure pump system of a high-performance liquid chromatograph, which comprises a case, wherein a mobile phase channel switching valve assembly, a first pump assembly, a second pump assembly, an evacuation valve, a high-pressure mixer and a plunger rod cleaning pump are arranged on the case, the mobile phase channel switching valve assembly is provided with a first inlet, a second inlet, a third inlet, a fourth inlet, a first outlet and a second outlet, the first outlet can be switched to communicate with the first inlet or the second inlet, the second outlet can be switched to communicate with the third inlet or the fourth inlet, the first outlet is communicated with the first pump assembly, the second outlet is communicated with the second pump assembly, the first pump assembly and the second pump assembly are jointly communicated with the evacuation valve, the evacuation valve is connected with the high-pressure mixer, and the first pump assembly and the second pump assembly are connected with the plunger rod cleaning pump. The invention has the high precision and high stability of the binary high-pressure liquid chromatograph, has the multi-channel transfusion capability of the quaternary low-pressure liquid chromatograph, and can automatically switch flow paths and automatically flush chromatographic columns.
Description
Technical Field
The invention relates to the technical field of high performance liquid chromatographs, in particular to a four-channel binary high-pressure pump system of a high performance liquid chromatograph.
Background
Most high-pressure infusion pump systems of high-performance liquid chromatographs in the current market are divided into two modes of binary high pressure and quaternary low pressure.
First kind: the two high-pressure infusion pumps are used for respectively conveying one liquid, the two liquids conveyed by the two high-pressure infusion pumps are mixed after the pumps, namely high-pressure mixing, each pump independently controls the flow speed accuracy in the working mode, and the two high-pressure infusion pumps have the characteristics of good stability, high accuracy and the like, but only two channels are used for conveying the liquid. If the customer chooses to install the autosampler, the instrument needs to work for more than ten hours, and the instrument can work late or even late to midnight when the instrument is finished and stops working. The most critical component of the high performance liquid chromatograph is the chromatographic column, the chromatographic column generally needs to be washed after the use is finished, otherwise, the performance and the service life of the chromatographic column are greatly influenced, but the washing of the chromatographic column generally needs to be carried out by using water and another organic liquid (commonly used methanol or acetonitrile), but because the binary high pressure liquid chromatograph has only two infusion channels and is occupied by the mobile phase of a normal detection sample, the binary high pressure liquid chromatograph cannot directly carry out automatic washing of the chromatographic column after the normal detection work is finished, the customer is required to have to make normal test work before going off duty, and then the liquid (mobile phase) of the two channels is manually replaced to wash the chromatographic column, so that the customer using the binary high pressure liquid chromatograph needs to be overtime, and the real unattended state cannot be achieved.
Second kind: the four-component low-pressure, namely four electromagnetic valves are added at the liquid inlet of a four-component low-pressure high-performance liquid chromatograph, namely a high-pressure infusion pump, so that four-component and one-component flow path channels are formed, the outlet of the four-component low-pressure liquid chromatograph is the inlet of the high-pressure infusion pump, four liquids (mobile phases) can be placed in the working mode, the four-component low-pressure liquid chromatograph has the capability of automatically switching flow paths, and can directly and automatically flush a chromatographic column after the normal detection work is finished, the structure is simple and low in cost, but the structure sacrifices the performance to a certain extent, because the quantity of liquid flowing into each channel is accurately controlled, the four-component low-pressure infusion pump is realized by the opening time of each electromagnetic valve, if two or more types of liquids are simultaneously conveyed, the liquids need to be respectively sucked into the inlets of the high-pressure infusion pump in sequence, and three problems can be caused: 1. the flow accuracy of the pump liquid is not as accurate and stable as that of the pump liquid directly using the high-pressure infusion pump; 2. the liquid is mixed when not entering the inlet of the high-pressure liquid delivery pump, and at the moment, the liquid is in a low-pressure state, and two different liquids meet in a state without pressure so as to easily generate bubbles, so that the liquid delivery pump system of the quaternary low-pressure high-performance liquid chromatograph is required to be added with an online degasser, the equipment cost is increased in the mode, and the online degasser belongs to a consumable product, so that the use cost is additionally increased for a user. 3. Because a plurality of liquids are sucked into the high-pressure infusion pump respectively from front to back, the requirement on the mixing capability of the liquids is higher, and the situation of uneven mixing is easy to occur, so that the detection result is unstable.
Disclosure of Invention
In view of the shortcomings of the background technology, the invention provides a four-channel binary high-pressure pump system of a high-performance liquid chromatograph, and the technical problem to be solved is how to automatically switch flow paths and realize the function of multi-channel transfusion, and ensure the accuracy and stability of detection results.
In order to solve the technical problems, the invention provides the following technical scheme:
The four-channel binary high-pressure pump system of the high-performance liquid chromatograph comprises a case, wherein a mobile communication channel switching valve assembly, a first pump assembly, a second pump assembly, an evacuation valve, a high-pressure mixer and a plunger rod cleaning pump are arranged on the case, the mobile communication channel switching valve assembly is provided with a first inlet, a second inlet, a third inlet and a fourth inlet, and is also provided with a first outlet and a second outlet, the first outlet is in switchable communication with the first inlet or the second inlet, the second outlet is in switchable communication with the third inlet or the fourth inlet, the first outlet is in communication with the first pump assembly, the second outlet is in communication with the second pump assembly, the first pump assembly and the second pump assembly are in common communication with the evacuation valve, the evacuation valve is connected with the high-pressure mixer, and the first pump assembly and the second pump assembly are connected with the plunger rod cleaning pump.
The first pump assembly comprises a first pump head and a second pump head, the second pump assembly comprises a third pump head and a fourth pump head, the first pump head and the third pump head are identical in structure, and the second pump head and the fourth pump head are identical in structure.
The first pump head comprises a first pump head body, a first plunger rod cleaning seat and a first plunger rod capable of reciprocating, the first pump head body is provided with a first flow passage cavity, a first outlet check valve and a first inlet check valve, the first outlet check valve and the first inlet check valve are communicated with the first flow passage cavity, the first pump head body is fixedly arranged on the first plunger rod cleaning seat, a first channel, a first cleaning inlet and a first cleaning outlet which are communicated with the first channel are arranged on the first plunger rod cleaning seat in a penetrating manner, a first high-pressure sealing ring and a first low-pressure sealing ring are sequentially sleeved on the first plunger rod, the first plunger rod can penetrate through the first channel and enter the first flow passage cavity, in the process, the first high-pressure sealing ring on the first plunger rod always tightly abuts against the inner wall of the first flow passage cavity, and the first low-pressure sealing ring on the first plunger rod always tightly abuts against the inner wall of the first channel.
The first plunger rod is connected with a first push rod, and the first push rod is driven by a first transmission device.
The first transmission device is a first motor.
The second pump head comprises a second pump head body, a second plunger rod cleaning seat and a second plunger rod capable of reciprocating, wherein the second pump head body is provided with a second flow channel cavity, a second outlet and a second inlet, the second outlet and the second inlet are communicated with the second flow channel cavity, the second pump head body is fixedly arranged on the second plunger rod cleaning seat, a second channel, a second cleaning inlet and a second cleaning outlet, which are communicated with the second channel, are arranged on the second plunger rod cleaning seat in a penetrating manner, a second high-pressure sealing ring and a second low-pressure sealing ring are sequentially sleeved on the second plunger rod, the second plunger rod can penetrate through the second channel and enter the second flow channel cavity, in the process, the second high-pressure sealing ring on the second plunger rod always tightly abuts against the inner wall of the second flow channel cavity, and the second low-pressure sealing ring on the second plunger rod always tightly abuts against the inner wall of the second channel.
The second plunger rod is connected with a second push rod, and the second push rod is driven by a second transmission device.
The second transmission device is a second motor.
The emptying valve comprises a valve body, the valve body is provided with a valve cavity, a knob is connected to the valve body in a threaded manner, a sealing cone is arranged on the knob, a conical hole matched with the sealing cone is formed in the front end of the valve body, the conical hole is communicated with the valve cavity, a first liquid inlet hole, a second liquid inlet hole and a liquid outlet hole which are respectively communicated with the valve cavity are formed in the valve body, an emptying hole which is correspondingly communicated with the conical hole is further formed in the valve body, a premixed filter disc used for filtering liquid is arranged in the valve cavity, and a pressure sensor is connected to the rear end of the valve body in a threaded manner.
Compared with the prior art, the invention has the following beneficial effects: the dual high-pressure liquid chromatograph has high accuracy and high stability, has the multi-channel transfusion capability of the quaternary low-pressure liquid chromatograph, realizes the technical effect of high-pressure mixing of liquid, can automatically switch flow paths and automatically flush chromatographic columns after normal detection work is finished, and effectively saves time of staff.
Drawings
The invention has the following drawings:
FIG. 1 is a schematic illustration of the present invention;
FIG. 2 is a partial schematic view of FIG. 1;
FIG. 3 is an exploded view of the first pump head of FIG. 1;
Fig. 4 is an exploded schematic view of the evacuation valve of fig. 1.
Detailed Description
As shown in the figure, the four-channel binary high-pressure pump system of the high-performance liquid chromatograph comprises a machine case 1, wherein a mobile phase channel switching valve assembly 2, a first pump assembly, a second pump assembly, an evacuation valve 5, a high-pressure mixer 3 and a plunger rod cleaning pump 4 are arranged on the machine case 1, the mobile phase channel switching valve assembly 2 is provided with a first inlet 21, a second inlet 22, a third inlet 23 and a fourth inlet 24, and is also provided with a first outlet 25 and a second outlet 26, wherein the first inlet 21, the second inlet 22, the third inlet 23 and the fourth inlet 24 are used for introducing liquid to be tested and are respectively connected with a liquid pipeline, the first outlet 25 is switchably communicated with the first inlet 21 or the second inlet 22, the second outlet 26 is switchably communicated with the third inlet 23 or the fourth inlet 24, the first outlet 25 is communicated with the first pump assembly, the second outlet 26 is communicated with the second pump assembly, the first pump assembly and the second pump assembly are jointly communicated with the evacuation valve 5, the evacuation valve 5 is used for premixing liquid, the evacuation valve 5 is connected with the high-pressure mixer 3, the high-pressure mixer 3 is used for performing the high-performance liquid mixing and the plunger rod cleaning pump 4 is connected with the second pump assembly, and the plunger rod cleaning pump assembly is used for cleaning the plunger rod cleaning pump assembly.
In the present embodiment, the first pump assembly includes the first pump head 7 and the second pump head 8, the second pump assembly includes the third pump head 9 and the fourth pump head 10, the structures of the first pump head 7 and the third pump head 9 are the same, and the structures of the second pump head 8 and the fourth pump head 10 are the same.
The specific structure of the first pump head 7 is as follows: the first pump head 7 comprises a first pump head body 75, a first plunger rod cleaning seat 76 and a first plunger rod 77 capable of reciprocating, wherein the first pump head body 75 is provided with a first flow passage cavity, a first outlet check valve 71 and a first inlet check valve 72 which are communicated with the first flow passage cavity, the first pump head body 75 is fixedly arranged on the first plunger rod cleaning seat 76, a first channel, a first cleaning inlet 73 and a first cleaning outlet 74 which are communicated with the first channel are arranged on the first plunger rod cleaning seat 76 in a penetrating manner, a first high-pressure sealing ring 771 and a first low-pressure sealing ring 772 are sequentially sleeved on the first plunger rod 77, the first plunger rod 77 can penetrate through the first channel and enter the first flow passage cavity, in the process, the first high-pressure sealing ring 771 on the first plunger rod 77 is always tightly abutted against the inner wall of the first flow passage cavity, and the first low-pressure sealing ring 772 on the first plunger rod 77 is always tightly abutted against the inner wall of the first channel. The first plunger rod 77 is connected to a first push rod 78, and the first push rod 78 is driven by a first transmission device, which in this embodiment is a first motor.
The specific structure of the second pump head 8 is as follows: the second pump head 8 comprises a second pump head body, a second plunger rod cleaning seat and a second plunger rod capable of reciprocating, wherein the second pump head body is provided with a second flow channel cavity, a second outlet 26 and a second inlet 22 which are communicated with the second flow channel cavity, the second pump head body is fixedly arranged on the second plunger rod cleaning seat, a second channel, a second cleaning inlet and a second cleaning outlet which are communicated with the second channel are arranged on the second plunger rod cleaning seat in a penetrating manner, a second high-pressure sealing ring and a second low-pressure sealing ring are sequentially sleeved on the second plunger rod, the second plunger rod can penetrate through the second channel and enter the second flow channel cavity, in the process, the second high-pressure sealing ring on the second plunger rod is always tightly abutted against the inner wall of the second flow channel cavity, and the second low-pressure sealing ring on the second plunger rod is always tightly abutted against the inner wall of the second channel. The second plunger rod is connected with a second push rod, the second push rod is driven by a second transmission device, and the second transmission device is a second motor.
It follows that the second pump head 8 differs from the first pump head 7 in that the first pump head 7 body of the first pump head 7 has a first outlet check valve 71 and a first inlet check valve 72 communicating with the first flow path chamber, whereas the second pump head 8 has only a second outlet 26 and a second inlet 22 communicating with the second flow path chamber.
The first pump head 7, the second pump head 8, the third pump head 9, and the fourth pump head 10 cooperate to realize a separation function between the high-pressure flow path and the cleaning flow path, for example: the first pump head body 75 is mainly responsible for high-pressure circulation, and the first plunger rod cleaning seat 76 is mainly responsible for cleaning the first plunger rod 77, so that the influence of the flow of buffer salt on the service life of the high-pressure sealing ring is solved.
In this embodiment, the evacuation valve 5 includes a valve body 51, the valve body 51 has a valve cavity, a knob 54 is screwed on the valve body 51, a sealing cone 55 is provided on the knob 54, a conical hole matched with the sealing cone 55 is provided at the front end of the valve body 51, the conical hole is connected with the valve cavity, a first liquid inlet 57, a second liquid inlet and a liquid outlet 56 respectively connected with the valve cavity are provided on the valve body 51, an evacuation hole 53 corresponding to the conical hole is provided, a premixing filter disc for filtering liquid is provided in the valve cavity, and a pressure sensor is screwed at the rear end of the valve body.
Before the emptying valve 5 performs emptying operation, the knob 54 is screwed, the sealing cone 55 on the knob 54 seals the conical hole on the valve body 1, at this time, the sealing cone 55 also seals the inlet of the emptying hole 53, meanwhile, the pressure sensor 52 is screwed on the valve body 1, in this case, the first liquid inlet hole 57, the second liquid inlet hole and the liquid outlet hole 56 are all communicated with the valve cavity, the pressure sensing surface of the pressure sensor 52 faces the valve cavity and can directly sense the pressure of liquid in the valve cavity, then, two paths of liquid enter the first liquid inlet hole 57 and the second liquid inlet hole through the first liquid inlet pipe and the second liquid inlet pipe respectively, then enter the valve cavity and are mixed, the mixed liquid flows out of the liquid outlet hole 56, and the pressure sensing surface of the pressure sensor 52 always monitors the pressure of the liquid in the valve cavity in the whole process.
When the evacuation valve 5 performs evacuation operation, the knob 54 is unscrewed, a gap is formed between the sealing cone 55 and the conical hole, and a gap is formed between the conical hole and the evacuation hole 53, in this case, the evacuation hole 53, the first liquid inlet hole 57, the second liquid inlet hole and the liquid outlet hole 56 are all communicated with the valve cavity, and the pressure sensing surface of the pressure sensor 52 faces the valve cavity and can directly sense the pressure of liquid in the valve cavity.
The working principle of this embodiment is as follows:
One of the first inlet 21 and the second inlet 22 of the flow channel switching valve assembly 2 is controlled by the programmable controller to communicate with the first pump assembly, while one of the third inlet 23 and the fourth inlet 24 of the flow channel switching valve assembly 2 is controlled to communicate with the second pump assembly, and the combination of the communications is four: 1. the first inlet 21 communicates with the first pump assembly and the third inlet 23 communicates with the second pump assembly; 2. the first inlet 21 communicates with the first pump assembly and the fourth inlet 24 communicates with the second pump assembly; 3. the second inlet 22 communicates with the first pump assembly and the third inlet 23 communicates with the second pump assembly; 4. the second inlet 22 communicates with the first pump assembly and the fourth inlet 24 communicates with the second pump assembly. Assuming the first communication mode is selected, two liquids to be tested can be respectively introduced into the first inlet 21 and the third inlet 23, and organic liquids for flushing the chromatographic column can be introduced into the second inlet 22 and the fourth inlet 24, after the device is started, the two liquids to be tested respectively pass through the first pump assembly and the second pump assembly and enter the exhaust valve 5 to be premixed, then enter the high-pressure mixer 3 to be subjected to precise mixing, and finally flow out of the high-pressure mixer 3. After the detection is completed, the programmable controller can automatically start the cleaning work of the chromatographic column, and under the condition of no supervision, the organic liquid which is introduced into the mobile phase channel switching valve assembly 2 from the second inlet 22 and the fourth inlet 24 is introduced into the corresponding first pump assembly and the second pump assembly, and then flows out through the emptying valve 5 and the high-pressure mixer 3 in sequence, so as to clean the chromatographic column. In this process, the programmable controller may set time, and the cleaning solution is introduced into the cleaning inlet 101 of the fourth pump head 10 of the second pump assembly, and the cleaning solution respectively performs timing cleaning on the plunger rods in the first pump assembly and the second pump assembly under the cooperation of the plunger rod cleaning pump 4, specifically: the cleaning liquid flows out from the cleaning outlet 91 of the third plunger rod cleaning seat of the third pump head 9 via the fourth plunger rod cleaning seat of the fourth pump head 10, the first plunger rod cleaning seat 76 of the first pump head 7, the plunger rod cleaning pump 4, the second plunger rod cleaning seat of the second pump head 8.
In summary, the invention can automatically switch flow paths and realize the function of multi-channel transfusion, and ensure the accuracy and stability of detection results.
Claims (5)
1. Four-channel binary high-pressure pump system of high-performance liquid chromatograph, including the machine case, its characterized in that: the mobile phase channel switching valve assembly is provided with a first inlet, a second inlet, a third inlet and a fourth inlet, and is also provided with a first outlet and a second outlet, the first outlet is in switchable communication with the first inlet or the second inlet, the second outlet is in switchable communication with the third inlet or the fourth inlet, the first outlet is communicated with the first pump assembly, the second outlet is communicated with the second pump assembly, the first pump assembly and the second pump assembly are communicated with the evacuation valve together, the evacuation valve is connected with the high-pressure mixer, and the first pump assembly and the second pump assembly are connected with the plunger rod cleaning pump;
The first pump assembly comprises a first pump head and a second pump head, the second pump assembly comprises a third pump head and a fourth pump head, the first pump head and the third pump head are identical in structure, and the second pump head and the fourth pump head are identical in structure;
The first pump head comprises a first pump head body, a first plunger rod cleaning seat and a first plunger rod capable of reciprocating, wherein the first pump head body is provided with a first flow passage cavity, a first outlet one-way valve and a first inlet one-way valve which are communicated with the first flow passage cavity;
The second pump head comprises a second pump head body, a second plunger rod cleaning seat and a second plunger rod capable of reciprocating, wherein the second pump head body is provided with a second flow channel cavity, a second outlet and a second inlet which are communicated with the second flow channel cavity, the second pump head body is fixedly arranged on the second plunger rod cleaning seat, a second channel, a second cleaning inlet and a second cleaning outlet which are communicated with the second channel are arranged on the second plunger rod cleaning seat in a penetrating manner, a second high-pressure sealing ring and a second low-pressure sealing ring are sequentially sleeved on the second plunger rod, the second plunger rod can penetrate through the second channel and enter the second flow channel cavity, in the process, the second high-pressure sealing ring on the second plunger rod always tightly abuts against the inner wall of the second flow channel cavity, and the second low-pressure sealing ring on the second plunger rod always tightly abuts against the inner wall of the second channel;
The emptying valve comprises a valve body, the valve body is provided with a valve cavity, a knob is connected to the valve body in a threaded manner, a sealing cone is arranged on the knob, a conical hole matched with the sealing cone is formed in the front end of the valve body, the conical hole is communicated with the valve cavity, a first liquid inlet hole, a second liquid inlet hole and a liquid outlet hole which are respectively communicated with the valve cavity are formed in the valve body, an emptying hole which is correspondingly communicated with the conical hole is further formed in the valve body, a premixed filter disc used for filtering liquid is arranged in the valve cavity, and a pressure sensor is connected to the rear end of the valve body in a threaded manner.
2. The four-way binary high pressure pump system of a high performance liquid chromatograph of claim 1, wherein: the first plunger rod is connected with a first push rod, and the first push rod is driven by a first transmission device.
3. The four-way binary high pressure pump system of the high performance liquid chromatograph of claim 2, wherein: the first transmission device is a first motor.
4. The four-way binary high pressure pump system of a high performance liquid chromatograph of claim 1, wherein: the second plunger rod is connected with a second push rod, and the second push rod is driven by a second transmission device.
5. The four-way binary high pressure pump system of the high performance liquid chromatograph of claim 4, wherein: the second transmission device is a second motor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910305223.1A CN109944762B (en) | 2019-04-16 | 2019-04-16 | Four-channel binary high-pressure pump system of high-performance liquid chromatograph |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910305223.1A CN109944762B (en) | 2019-04-16 | 2019-04-16 | Four-channel binary high-pressure pump system of high-performance liquid chromatograph |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109944762A CN109944762A (en) | 2019-06-28 |
| CN109944762B true CN109944762B (en) | 2024-05-14 |
Family
ID=67015286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910305223.1A Active CN109944762B (en) | 2019-04-16 | 2019-04-16 | Four-channel binary high-pressure pump system of high-performance liquid chromatograph |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109944762B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111336078B (en) * | 2020-03-03 | 2022-02-25 | 大连依利特分析仪器有限公司 | Double-plunger liquid chromatography infusion pump, pump regulation and control method and pump system |
| CN212207226U (en) * | 2020-06-10 | 2020-12-22 | 上海贝高医疗科技有限公司 | Static sample introduction and flow fraction collection device matched with liquid chromatograph |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001255316A (en) * | 2000-03-08 | 2001-09-21 | Shimadzu Corp | Liquid chromatograph and flow channel changeover valve |
| CN102053132A (en) * | 2009-11-04 | 2011-05-11 | 北京普源精电科技有限公司 | Liquid chromatograph with plunger rod ejection pin |
| CN105358257A (en) * | 2013-07-19 | 2016-02-24 | 格瑞克明尼苏达有限公司 | Movable breaker system for lumpy material |
| CN207297318U (en) * | 2017-08-08 | 2018-05-01 | 江苏同济分析仪器有限公司 | A kind of automatic cleaning system of leggy liquid chromatograph high pressure pump |
| CN108302029A (en) * | 2018-03-22 | 2018-07-20 | 苏州英赛斯智能科技有限公司 | A kind of infusion pump and liquid chromatographic system |
| CN207764176U (en) * | 2018-01-25 | 2018-08-24 | 无锡赛那尔仪器设备制造有限公司 | A kind of automatic-discharging structure of liquid chromatograph |
| CN109154291A (en) * | 2016-09-26 | 2019-01-04 | 株式会社岛津制作所 | Switching valve, binary pump and the liquid chromatograph for having the binary pump |
| CN209724597U (en) * | 2019-04-16 | 2019-12-03 | 无锡赛那尔仪器设备制造有限公司 | The four-way binary high pressure pump system of high performance liquid chromatograph |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015189927A1 (en) * | 2014-06-11 | 2015-12-17 | 株式会社島津製作所 | Liquid-sample introduction device |
-
2019
- 2019-04-16 CN CN201910305223.1A patent/CN109944762B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001255316A (en) * | 2000-03-08 | 2001-09-21 | Shimadzu Corp | Liquid chromatograph and flow channel changeover valve |
| CN102053132A (en) * | 2009-11-04 | 2011-05-11 | 北京普源精电科技有限公司 | Liquid chromatograph with plunger rod ejection pin |
| CN105358257A (en) * | 2013-07-19 | 2016-02-24 | 格瑞克明尼苏达有限公司 | Movable breaker system for lumpy material |
| CN109154291A (en) * | 2016-09-26 | 2019-01-04 | 株式会社岛津制作所 | Switching valve, binary pump and the liquid chromatograph for having the binary pump |
| CN207297318U (en) * | 2017-08-08 | 2018-05-01 | 江苏同济分析仪器有限公司 | A kind of automatic cleaning system of leggy liquid chromatograph high pressure pump |
| CN207764176U (en) * | 2018-01-25 | 2018-08-24 | 无锡赛那尔仪器设备制造有限公司 | A kind of automatic-discharging structure of liquid chromatograph |
| CN108302029A (en) * | 2018-03-22 | 2018-07-20 | 苏州英赛斯智能科技有限公司 | A kind of infusion pump and liquid chromatographic system |
| CN209724597U (en) * | 2019-04-16 | 2019-12-03 | 无锡赛那尔仪器设备制造有限公司 | The four-way binary high pressure pump system of high performance liquid chromatograph |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109944762A (en) | 2019-06-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20230135114A1 (en) | Sample Injector With Metering Device Balancing Pressure Differences In An Intermediate Valve State | |
| US8048312B2 (en) | Separation analyzer | |
| CN110455970B (en) | Sampling fraction collecting device and system | |
| CN109100458B (en) | Automatic chromatographic sample injector and automatic sample injection method | |
| CN102171562B (en) | Liquid chromatography device and liquid chromatography | |
| CN109944762B (en) | Four-channel binary high-pressure pump system of high-performance liquid chromatograph | |
| EP0022654B1 (en) | Liquid handling device | |
| US20130067997A1 (en) | Single injection valve for hplc combining sample introduction, wash cycles and diagnosis | |
| US11009488B2 (en) | Fluid chromatograph | |
| EP2990791B1 (en) | Switching valve for a flow-type analysis device | |
| JP2015092166A5 (en) | ||
| CN210690498U (en) | Chromatographic system for alternately and reversely cleaning chromatographic column by counting | |
| US20240060939A1 (en) | Sample metering and injection for liquid chromatography | |
| CN209724597U (en) | The four-way binary high pressure pump system of high performance liquid chromatograph | |
| JP2014106213A (en) | Liquid chromatograph auto-sampler | |
| CN217212479U (en) | Mobile phase channel switching structure and binary six-channel high-pressure infusion pump system | |
| CN211505358U (en) | Multi-element high-pressure infusion pump system of high performance liquid chromatograph | |
| JP7357787B2 (en) | Control method for automatic analyzer | |
| CN214750036U (en) | Automatic washing balance test equipment for chromatographic column | |
| CN117329326A (en) | Flow path switching device | |
| CN117582834A (en) | Inspection pretreatment multichannel liquid preparation system and liquid preparation method | |
| JP2022171634A (en) | Lc system and method with backflush of column | |
| CN112433009A (en) | Chromatographic system for alternately and reversely cleaning chromatographic column by counting |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |