CN109939358A - A kind of low-frequency range broadband magnetic field-therapeutic instrument and its application method for oncotherapy - Google Patents
A kind of low-frequency range broadband magnetic field-therapeutic instrument and its application method for oncotherapy Download PDFInfo
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Abstract
The present invention relates to a kind of low-frequency range broadband magnetic field-therapeutic instruments and its application method for oncotherapy, are mainly used in medical field.It is connected by host computer through main control unit, multi-channel wideband signal generating unit, signal conditioning unit, power amplification unit and Helmholtz coil group, main control unit is connect with signal conditioning unit, power amplification unit respectively, magnetic field measurement unit and temperature feedback unit are connect with host computer respectively, and magnetic field measurement unit adjusts unit through PID/feedback and connect composition with main control unit.The low-frequency range of the frequency band covering 0.1Hz-300Hz of magnetic field-therapeutic instrument according to the present invention, it is convenient to operate, magnetic direction and size are controllable, using when inhibit frequency to study without optimum magnetic field to different tumours in advance, both the time is saved, avoids the unsatisfactory curative effect due to caused by field frequency specificity, and improve efficiency, the universality that magnetic field therapy is applied to different tumours is increased, there can be significant inhibiting effect to kinds of tumors.
Description
Technical field
The present invention relates to magnetic field-therapeutic instrument field, especially a kind of low-frequency range broadband magnetic field treatment for oncotherapy
Instrument and its application method.
Background technique
Tumour is body under the action of various tumorigenesis factors, and the cell of local organization is lost at the genetic level to it
The normal regulation of growth leads to paraplasm and the neoplasm that is formed.It is endanger at present human health most serious disease it
One.Existing tumor therapeuticing method mainly includes chemotherapy and radiotherapy, and curative effect is not ideal enough, very big to function of human body damage,
Thus the more simple and effective novel green therapy of research is very necessary.It is exactly this that tumour is treated using the biological effect in magnetic field
A feasible developing direction in a little new treatments.Magnetic field can be divided into steady magnetic field and variable magnetic field, and the attribute of steady and variation removes
Have outside the Pass with magnetic field sources, also and the relative motion of magnetic field and body is closely related.The type in magnetic field and its difference of physical parameter
The different difference that will lead to biological effect caused by magnetic field.Also can again because frequency height is different, action time length is different variation magnetic field
Generate different biological effects.In recent years, newest research achievement shows that the low frequency electromagnetic field of 0-300Hz can have both at home and abroad
Effect inhibit tumor proliferation, inducing apoptosis of tumour cell, the inhibitory effect of different types of tumour mainly with the parameter of electromagnetic field (frequency
Rate, intensity, type) it is related, wherein field frequency is the most important factor for inhibiting tumor cell proliferation.Article " Cancer cell
Claim in proliferation is inhibited by specific modulation frequencies " text, low frequency electromagnetic
There is surprising effect in field in terms for the treatment of cancerous tumours.The study found that low frequency electromagnetic of the frequency at 0.1 hertz to 114 kilo hertzs
Field energy enough inhibits the growth of part patient's body malignant tumour.It is reported that various cancers correspond to different frequencies, this research at
Fruit perhaps can erase cancer from the list of incurable disease.
United States Patent (USP) US8019414, US8406870 disclose the intermediate frequency magnetic field-therapeutic instrument of 100-300kHz a kind of, can answer
For recurring and initial gliablastoma.United States Patent (USP) US8192969 disclose one can produce 1-1000Hz and
The device of 1-100mT electromagnetic field can intervene the survival of cell.
CN1053555 discloses " cancer curing device using strong magnetic field ", proposes that a kind of magnetic field strength for treating cancer is higher than 0.4
The magnetic therapy type cancer curing device using strong magnetic field of tesla (T).The magnetic field device that high-intensity magnetic field can be generated includes constant high-intensity magnetic field device and arteries and veins
Rush high-intensity magnetic field device.
CN2721133Y discloses " pulse electromagnetic field therapeutic apparatus for treating tumor ", proposes a kind of for treating malignant tumor
Pulse electromagnetic field.
CN207168835U discloses " the power frequency electromagnetic field generating device with tumor inhibition effect ", CN106621050A
" power frequency electromagnetic field generating device and loading method with tumor inhibition effect " is disclosed, a kind of electricity of depression effect is proposed
Magnetic field, loading method have certain expansion, and frequency is static to exist with alternating magnetic field intensity rate within the scope of 30-300Hz
Within the scope of 0.5-2.5, overall strength is within the scope of 1-10mT.It may act on organism, noninvasive low toxicity side effect, to kinds of tumors
With significant inhibiting effect, magnetic fields can increase intracellular superoxide radical content, and promote cell autophagy.
The above technology is all directed to in-vivo tumour treatment or tumor cell in vitro experiment proposes alternating magnetic field or steady magnetic
The device for the treatment of, frequency is adjustable with field strength range, but when running, and is only capable of generating the magnetic field with single-frequency, and tumour
Treatment have frequency dependence, different tumours are not available single-frequency and reach optimum therapeuticing effect, in order to promoted magnetic field application in
The universality of different tumour cell treatments.
Summary of the invention
The purpose of the present invention in view of the above shortcomings of the prior art, provides a kind of low-frequency range broadband for oncotherapy
Magnetic field-therapeutic instrument.
Another object of the present invention is just to provide a kind of answering for low-frequency range broadband magnetic field-therapeutic instrument for oncotherapy
Use method
The invention is realized in this way
A kind of low-frequency range broadband magnetic field-therapeutic instrument for oncotherapy, the therapeutic equipment include: host computer, master control list
Member, multi-channel wideband signal generating unit, signal conditioning unit, power amplification unit, Helmholtz coil group, magnetic-field measurement list
Member, PID/feedback adjust unit and temperature feedback unit, wherein
The host computer is conveyed to main control unit and is instructed；
Main control unit control multi-channel wideband signal generating unit generates direct current signal, via signal conditioning unit with
And it is output in Helmholtz coil group after power amplification unit processing；
The Helmholtz coil group generates magnetic field；
Magnetic field measurement unit measuring center region field strength is sent to after PID/feedback adjusts unit and passes through by PID/feedback tune
Section unit is sent to main control unit, forms closed-loop feedback control system；
The temperature information in the temperature feedback unit measurement measurement each corner of Helmholtz coil group feeds back to host computer
So that temperature is stablized in the received normal temperature range of human body.
Further, the Helmholtz coil group is that radius is identical, and the annulus of the multipair coil composition of equal turn numbers makes
Used time human body is located in annulus, wherein each pair of coil is coaxial, and the spacing between each pair of coil is equal, and each pair of coil is by same root
Copper wire winding forms, and the number of turns is identical, and multipair hub of a spool is generally aligned in the same plane.
Further, the coil is 4 pairs, is revolved clockwise via a pair of of coil therein through plane where each hub of a spool
Turning 45,90,135 degree can be overlapped respectively with other coils.
Further, multi-channel wideband signal generating unit generates the direct current letter that the multichannel current value of corresponding multipair coil is
Number.
Further, the host computer receives the temperature information feedback in each corner of temperature feedback unit testing, if warm
Degree is stablized within the scope of blood heat, then security test passes through；If host computer passes through when subnormal temperature range
Main control unit adjusts the size of current that multi-channel wideband signal generating unit generates, until temperature is stablized in blood heat's model
It encloses, carries out safety test, and extract the current range I of multi-channel wideband signal generating unit output at this timed~Iu, it is denoted as " safety
Input current range ".
Further, the host computer conveys stability test instruction to main control unit, and main control unit controls multi-channel wide
It is I that frequency signal generating unit, which generates multichannel current value,inDirect current signal, pass through main control unit extracts power amplification to host computer simultaneously
The output electric current I of unitout, and utilize current value IoutAnd Helmholtz coil group model carries out physical field emulation, obtains magnetic field
The magnetic field strength B of center homogeneous area0, and by field intensity value B0It is sent to PID/feedback and adjusts unit, as default magnetic field strength；Magnetic
Field measurement unit acquires the field strength and directional information of central magnetic field in real time, all the way through main control unit by Helmholtz coil group center
The magnetic direction that region measures is sent to host computer and records preservation by host computer；Central area field strength is sent to PID by another way
Feedback regulation unit forms closed-loop feedback control system.
A kind of application method of the low-frequency range broadband magnetic field-therapeutic instrument for oncotherapy, comprising: surveyed including safety
Examination, stability test and treatment stage；
Wherein, security test, host computer convey security test instruction to main control unit, and main control unit controls multichannel
It is I that broadband signal generating unit, which generates multichannel current value,0Direct current signal, through signal conditioning unit, power amplification unit and the last of the twelve Earthly Branches
Mu Huozi coil group is connected, and the temperature that temperature feedback unit will be distributed over each corner of Helmholtz coil group through main control unit is believed
Breath feeds back to host computer, if temperature is stablized within the scope of blood heat, security test passes through；If being lower than human normal
When temperature range, then host computer adjusts the size of current that multi-channel wideband signal generating unit generates by main control unit, until
Temperature is stablized within the scope of blood heat, and safety test passes through；Host computer extracts multi-channel wideband at this time through main control unit
The current range I of signal generating unit outputd~Iu, it is denoted as " safe input current range ", is used for follow-up test and treatment, if
Input current is beyond within the scope of this, then system does not work；
Stability test: safe input current range chooses a current value IinAs input current, host computer is to master control list
Member conveys stability test instruction, and host computer extracts the output electric current I of power amplification unit by main control unit simultaneouslyout, and benefit
With current value IoutAnd Helmholtz coil group model carries out physical field emulation, obtains the magnetic field strength of magnetic field center homogeneous area
B0, and by field intensity value B0It is sent to PID/feedback and adjusts unit, as default magnetic field strength, magnetic field measurement unit acquires center in real time
The field strength and directional information in magnetic field, the magnetic direction for all the way measuring Helmholtz coil group central area through main control unit are sent
It is recorded and is saved by host computer to host computer；Central area field strength is sent to PID/feedback and adjusts unit by another way, and it is anti-to form closed loop
Control system is presented, wherein PID/feedback adjusts unit and is responsible for reducing the magnetic field strength currently measured and default magnetic field strength B0Between
Steady-state error, until error is less than setting value, PID/feedback adjusts unit and stops working, host computer record multi-channel wide at this time
The current value I of frequency signal generating unit outputw, it is denoted as " operating current ", stability test passes through；
Treatment stage: host computer conveys firing order, multichannel to multi-channel wideband signal generating unit through main control unit
Broadband signal generating unit generates the white noise signal that intensity is equal to " operating current ", after signal conditioning unit is handled, through function
Signal is inputted Helmholtz coil pair by rate amplifying unit respectively, the uniform magnetic field of certain space is generated in central area, to disease
The tumour in people affected part carries out non-invasively treating.
Further, if being lower than blood heat's range in security test, multi-channel wideband signal is occurred single
The current regulation that member generates is I0+5mA；When higher than blood heat's range, then reduce multi-channel wideband signal generating unit
The electric current of generation is to I0-5mA。
Further, if PID/feedback adjusts the specific regulative mode of unit and shows themselves in that current magnetic field intensity is greater than default magnetic field
Intensity, then by input current IinIt turns down, conversely, then increasing current input current signal IinIt is turned up.
Further, the intensity that magnetic field is irradiated in treatment stage is related with input current, when needing increasing magnetic field, needs
Input current value is improved, and re-start stability test in " safe input current range ".
Compared with prior art, the present invention beneficial effect is: present invention covers the electromagnetism with tumor inhibition effect
Field frequencies range section, magnetic field-therapeutic instrument realize the generation in the magnetic field of random frequency in 0.1Hz-300Hz frequency range, will be several effective
Tumor suppression frequency is integrated together, safety and stability, and it is convenient to operate, and magnetic direction and size are controllable, without in advance to difference when application
The optimum magnetic field of tumour inhibits frequency to be studied, and both saves the time, avoids the curative effect due to caused by field frequency specificity
It is bad, and efficiency is improved, the universality that magnetic field therapy is applied to different tumours is increased, there can be significant suppression to kinds of tumors
Production is used.
Detailed description of the invention
Fig. 1 present invention is used for the low-frequency range broadband magnetic field-therapeutic instrument system block diagram of oncotherapy；
Schematic diagram in Fig. 2 low-frequency range broadband magnetic field-therapeutic instrument application of the present invention；
Fig. 3 Helmholtz coil group distribution schematic diagram of the present invention；
Fig. 4 physical field of the present invention emulates schematic diagram.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
Referring to Fig. 1
The present invention relates to a kind of low-frequency range broadband magnetic field-therapeutic instruments for oncotherapy, are by host computer 1 through master control
Unit 2, multi-channel wideband signal generating unit 3, signal conditioning unit 4, power amplification unit 5 and Helmholtz coil group 6 connect
It connects, main control unit 2 is connect with signal conditioning unit 4 and power amplification unit 5 respectively, temperature feedback unit 8 and 1 phase of host computer
Even, magnetic field measurement unit 7 adjusts unit 9 through PID/feedback and connect composition with main control unit 2.
The host computer is conveyed to main control unit and is instructed；The main control unit control multi-channel wideband signal generating unit produces
Raw direct current signal is output in Helmholtz coil group after handling via signal conditioning unit and power amplification unit；It is described
Helmholtz coil group generates magnetic field；Magnetic field measurement unit measuring center region field strength is sent to PID/feedback and adjusts unit
It is sent to main control unit by unit is adjusted by PID/feedback, forms closed-loop feedback control system；
The temperature information in the temperature feedback unit measurement measurement each corner of Helmholtz coil group feeds back to host computer
So that temperature is stablized in the received normal temperature range of human body.
In the present embodiment, the Helmholtz coil group 6 is that radius is identical, four pairs of coils composition of equal turn numbers, including
First pair of Helmholtz coil, second pair of Helmholtz coil, third to Helmholtz coil and the 4th pair of Helmholtz coil,
Distribution is as shown in figure 3, wherein each pair of coil is coaxial, and spacing is equal, is formed by same root copper wire winding, and the number of turns is identical, and four pairs
Hub of a spool is all generally aligned in the same plane, and first pair of Helmholtz coil rotates clockwise 45,90 through plane where each hub of a spool,
135 degree respectively can be with second pair of Helmholtz coil, and second pair of Helmholtz coil, third is to Helmholtz coil coincidence.
Shown in Figure 2, the Helmholtz coil group 6 is installed on adjustable support 10, and cancer portion can be suffered from according to patient
Position carries out the horizontal adjustment with upright position.
The present invention provides a kind of application method of low-frequency range broadband magnetic field-therapeutic instrument for oncotherapy, by following step
Rapid work: including security test, stability test and treatment stage.
A, security test:
Host computer 1 conveys security test instruction to main control unit 2, and main control unit 2 controls multi-channel wideband signal and occurs
It is I that unit 3, which generates four road current values,0Direct current signal, through signal conditioning unit 4, power amplification unit 5 and Helmholtz coil
Group 6 is connected, and the temperature information that temperature feedback unit 8 will be distributed over each corner of Helmholtz coil group 6 through main control unit 2 is fed back
To host computer 1, real-time monitoring 6 hours, if temperature is stablized in 36-37 degrees Celsius of blood heat's range, safety was surveyed
It pinged；If lower than 36 degrees Celsius or be higher than 37 degrees Celsius, host computer 1 adjusts multi-channel wideband letter by main control unit 2
The size of current that number generating unit 3 generates, until temperature is stablized in 36 to 37 degree Celsius ranges, safety test passes through.It is upper
Machine 1 extracts the current range I that multi-channel wideband signal generating unit 3 exports at this time through main control unit 2d~Iu, it is denoted as " safe defeated
Enter current range ", it is used for follow-up test and treatment, if input current is beyond within the scope of this, system not to work.
Specific regulative mode are as follows: if being lower than 36 degrees Celsius, the electric current tune that multi-channel wideband signal generating unit 3 is generated
Section is I0+5mA；When higher than 37 degrees Celsius, then reduce the electric current of the generation of multi-channel wideband signal generating unit 3 to I0-5mA。
B, stability test: in IdTo IuBetween, choose a current value IinAs input current, host computer 1 is to master control list
Member 2 conveys stability test instruction, and it is I that main control unit 2, which controls multi-channel wideband signal generating unit 3 and generates four road current values,in
Direct current signal, be input in Helmholtz coil group 6 after signal conditioning unit 4, power amplification unit 5.Host computer 1 is simultaneously
The output electric current I of power amplification unit 5 is extracted by main control unit 2out, and utilize current value IoutAnd Helmholtz coil group mould
Type carries out physical field emulation (shown in Figure 3), obtains the magnetic field strength B of magnetic field center homogeneous area0, and by field intensity value B0Hair
It send to PID/feedback and adjusts unit 9, as default magnetic field strength.Magnetic field measurement unit 7 acquires field strength and the side of central magnetic field in real time
To information, all the way through main control unit 2 by the magnetic direction that 6 central area of Helmholtz coil group measures be sent to host computer 1 by
Host computer record saves；Central area field strength is sent to PID/feedback and adjusts unit 9 by another way, forms closed loop feedback control system
System, wherein PID/feedback adjusts unit 9 and is responsible for reducing the magnetic field strength currently measured and default magnetic field strength B0Between stable state miss
Difference, until error, less than 1%, PID/feedback adjusts unit 9 and stops working, multi-channel wideband signal occurs the record of host computer 1 at this time
The current value I that unit 3 exportsw, it is denoted as " operating current ", stability test passes through.
If PID/feedback adjusts the specific regulative mode of unit 9 and shows themselves in that current magnetic field intensity is greater than default magnetic field strength,
By input current IinIt turns down, conversely, then increasing current input current signal IinIt is turned up.
C, treatment stage:
(1) firstly, suffering from the information at tumor position according to patient, the Hai Muhuo on adjustable support 10 is adjusted
The hereby upright position of coil group 6 makes in Helmholtz coil group 6 each coil center of circle suffer from cancer position same with patient
In plane, the horizontal position of Helmholtz coil group 6 is then adjusted, so that patient is suffered from cancer position and is located at the center of coil group 6；
(2) host computer 1 conveys firing order, multi-channel wideband to multi-channel wideband signal generating unit 3 through main control unit 2
Signal generating unit 3 generates the white noise signal that four tunnel intensity are equal to " operating current ", i.e., power spectral density is in entire frequency domain
It is evenly distributed, and intensity constant is IwSignal filtered out frequency greater than 300Hz and small after the processing of signal conditioning unit 4
In the signal of 0.1Hz, four road 0.1Hz-300Hz broad band low frequency signals are exported, it is through power amplification unit 5 that four road signals difference is defeated
Enter Helmholtz coil to 1, Helmholtz coil to 2, Helmholtz coil to 3 and Helmholtz coil to 4, Helmholtz's line
5 central area of circle group generates the uniform magnetic field of certain space, carries out non-invasively treating to the tumour in patient affected part, can be according to disease
Feelings difference, condition irradiate duration and irradiation magnetic field strength.It should be noted that the intensity in irradiation magnetic field is related with input current,
It when needing increasing magnetic field, needs in " safe input current range ", improves input current value, and re-start stability
After test, it could be used to treat.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (10)
1. a kind of low-frequency range broadband magnetic field-therapeutic instrument for oncotherapy, which is characterized in that the therapeutic equipment includes: upper
Machine, main control unit, multi-channel wideband signal generating unit, signal conditioning unit, power amplification unit, Helmholtz coil group,
Magnetic field measurement unit, PID/feedback adjust unit and temperature feedback unit, wherein
The host computer is conveyed to main control unit and is instructed；
The main control unit control multi-channel wideband signal generating unit generates direct current signal, via signal conditioning unit and function
It is output in Helmholtz coil group after the processing of rate amplifying unit；
The Helmholtz coil group generates magnetic field；
Magnetic field measurement unit measuring center region field strength is sent to after PID/feedback adjusts unit and passes through by PID/feedback adjusting list
Member is sent to main control unit, forms closed-loop feedback control system；
The temperature information in the temperature feedback unit measurement measurement each corner of Helmholtz coil group feeds back to host computer and makes
Temperature is stablized in the received normal temperature range of human body.
2. therapeutic equipment described in accordance with the claim 1, which is characterized in that the Helmholtz coil group is that radius is identical, the number of turns
The annulus of equal multipair coil composition, human body is located in annulus when use, wherein each pair of coil is coaxial, and between each pair of coil
Spacing it is equal, each pair of coil is formed by same root copper wire winding, and the number of turns is identical, and multipair hub of a spool is generally aligned in the same plane.
3. therapeutic equipment according to claim 2, which is characterized in that the coil is 4 pairs, is passed through via a pair of of coil therein
Plane where each hub of a spool rotates clockwise 45,90,135 degree and can be overlapped respectively with other coils.
4. therapeutic equipment according to claim 2, which is characterized in that it is multipair that multi-channel wideband signal generating unit generates correspondence
The direct current signal that the multichannel current value of coil is.
5. therapeutic equipment described in accordance with the claim 1, which is characterized in that the host computer receives each of temperature feedback unit testing
The temperature information in a corner is fed back, if temperature is stablized within the scope of blood heat, security test passes through；If lower than just
When normal temperature range, then host computer adjusts the size of current that multi-channel wideband signal generating unit generates by main control unit, directly
Stablize to temperature in blood heat's range, carry out safety test, and it is defeated to extract multi-channel wideband signal generating unit at this time
Current range I outd~Iu, it is denoted as " safe input current range ".
6. therapeutic equipment described in accordance with the claim 1, which is characterized in that the host computer conveys stability test to main control unit
Instruction, it is I that main control unit, which controls multi-channel wideband signal generating unit and generates multichannel current value,inDirect current signal, host computer is same
When by main control unit extract power amplification unit output electric current Iout, and utilize current value IoutAnd Helmholtz coil group mould
Type carries out physical field emulation, obtains the magnetic field strength B of magnetic field center homogeneous area0, and by field intensity value B0It is sent to PID/feedback tune
Unit is saved, as default magnetic field strength；Magnetic field measurement unit acquires the field strength and directional information of central magnetic field in real time, all the way through master
The magnetic direction that Helmholtz coil group central area measures is sent to host computer and records preservation by host computer by control unit；It is another
Central area field strength is sent to PID/feedback and adjusts unit by road, forms closed-loop feedback control system.
7. a kind of application method of the low-frequency range broadband magnetic field-therapeutic instrument for oncotherapy characterized by comprising including
Security test, stability test and treatment stage；
Wherein, security test, host computer convey security test instruction to main control unit, and main control unit controls multi-channel wideband
It is I that signal generating unit, which generates multichannel current value,0Direct current signal, through signal conditioning unit, power amplification unit and Hai Muhuo
Hereby coil group is connected, and the temperature information that temperature feedback unit will be distributed over each corner of Helmholtz coil group through main control unit is anti-
It feeds host computer, if temperature is stablized within the scope of blood heat, security test passes through；If being lower than blood heat
When range, then host computer adjusts the size of current that multi-channel wideband signal generating unit generates by main control unit, until temperature
Stablize within the scope of blood heat, safety test passes through；Host computer extracts multi-channel wideband signal at this time through main control unit
The current range I of generating unit outputd~Iu, it is denoted as " safe input current range ", is used for follow-up test and treatment, if input
Electric current is beyond within the scope of this, then system does not work；
Stability test: safe input current range chooses a current value IinAs input current, host computer is passed to main control unit
It is instructed up to stability test, host computer extracts the output electric current I of power amplification unit by main control unit simultaneouslyout, and utilize electricity
Flow valuve IoutAnd Helmholtz coil group model carries out physical field emulation, obtains the magnetic field strength B of magnetic field center homogeneous area0, and
By field intensity value B0It is sent to PID/feedback and adjusts unit, as default magnetic field strength, magnetic field measurement unit acquires central magnetic field in real time
Field strength and directional information, the magnetic direction that Helmholtz coil group central area measures is sent to through main control unit all the way
Position machine is recorded by host computer and is saved；Central area field strength is sent to PID/feedback and adjusts unit by another way, forms closed loop feedback control
System processed, wherein PID/feedback adjusts unit and is responsible for reducing the magnetic field strength currently measured and default magnetic field strength B0Between it is steady
State error, until error is less than setting value, PID/feedback adjusts unit and stops working, and host computer record at this time believe by multi-channel wideband
The current value I of number generating unit outputw, it is denoted as " operating current ", stability test passes through；
Treatment stage: host computer conveys firing order, multi-channel wideband to multi-channel wideband signal generating unit through main control unit
Signal generating unit generates intensity and puts after signal conditioning unit is handled through power equal to the white noise signal of " operating current "
Signal is inputted Helmholtz coil pair by big unit respectively, is generated the uniform magnetic field of certain space in central area, is suffered to patient
The tumour at place carries out non-invasively treating.
8. the application method for the low-frequency range broadband magnetic field-therapeutic instrument of oncotherapy according to claim 7, special
Sign is, if being lower than blood heat's range, the electricity that multi-channel wideband signal generating unit is generated in security test
Stream is adjusted to I0+5mA；When higher than blood heat's range, then reduce the electric current of multi-channel wideband signal generating unit generation
To I0-5mA。
9. the application method for the low-frequency range broadband magnetic field-therapeutic instrument of oncotherapy according to claim 7, special
Sign is, will if PID/feedback adjusts the specific regulative mode of unit and shows themselves in that current magnetic field intensity is greater than default magnetic field strength
Input current IinIt turns down, conversely, then increasing current input current signal IinIt is turned up.
10. the application method for the low-frequency range broadband magnetic field-therapeutic instrument of oncotherapy according to claim 7, special
Sign is that the intensity that magnetic field is irradiated in treatment stage is related with input current, when needing increasing magnetic field, needs in " safety
In input current range ", input current value is improved, and re-start stability test.
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Cited By (4)
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| CN110947099A (en) * | 2019-11-15 | 2020-04-03 | 郑州和济生物科技股份有限公司 | DC low-frequency pulse rotating magnetic field therapeutic equipment |
| CN112007277A (en) * | 2020-09-28 | 2020-12-01 | 四川大学华西医院 | Pulsed electromagnetic field device for breast cancer treatment |
| CN114019275A (en) * | 2021-10-28 | 2022-02-08 | 中国舰船研究设计中心 | Software-driven electromagnetic environment closed loop generation system and method |
| CN114796874A (en) * | 2022-05-10 | 2022-07-29 | 四川大学 | Magnetic field treatment device and method |
Citations (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1545985A (en) * | 2003-12-03 | 2004-11-17 | 宏 朱 | Magnetic heat treatment therapeutic apparatus for tumour |
| CN202401062U (en) * | 2011-12-16 | 2012-08-29 | 陈克明 | Low-frequency electromagnetic-field cell treater |
| CN102653719A (en) * | 2012-04-28 | 2012-09-05 | 吉林大学 | Cell culture device capable of generating multiple magnetic fields and culture method |
| CN103272332A (en) * | 2013-06-02 | 2013-09-04 | 南方医科大学 | Tumor therapy equipment with non-ionization electromagnetic field exciting autonomous metabolism of human body and application thereof |
| CN103520836A (en) * | 2013-10-14 | 2014-01-22 | 重庆大学 | Uniform pulsed magnetic field generator on basis of Helmholtz coil and IGBT (Insulated Gate Bipolar Transistor) module |
| US8968173B2 (en) * | 2008-07-16 | 2015-03-03 | Frank Sivo | Methods to arrest cancer cell growth and proliferation using electromagnetic energy delivered via electromagnetic coil systems |
| CN104436441A (en) * | 2013-09-16 | 2015-03-25 | 韦兆祥 | Device of treating solid tumors |
| CN105169561A (en) * | 2015-09-01 | 2015-12-23 | 丁建民 | Cancer treatment device |
| KR20160134889A (en) * | 2015-05-13 | 2016-11-24 | 고려대학교 산학협력단 | Treatment Apparatus for cancer by electromagnetic fields |
| WO2018017618A1 (en) * | 2016-07-18 | 2018-01-25 | Neotherma Oncology, Inc. | Systems and methods for targeted deep hyperthermia by time-shared rf inductive applicators |
| WO2018029569A1 (en) * | 2016-08-09 | 2018-02-15 | Politecnico Di Torino | Apparatus and method for the determination and the application of electromagnetic fields for influencing in vitro cell growth |
| CN108079441A (en) * | 2018-02-08 | 2018-05-29 | 四川大学华西医院 | A kind of Intelligent pulse electromagnetic apparatus and system for treating osteoporosis |
| CN108607162A (en) * | 2018-05-25 | 2018-10-02 | 浙江大学 | A kind of tumor suppression device of program control and use |
| CN109459712A (en) * | 2018-12-05 | 2019-03-12 | 三峡大学 | Vector closed loop compensation formula triaxial magnetic field sensor probe based on Helmholtz coil |
| CN109490973A (en) * | 2018-10-30 | 2019-03-19 | 吉林大学 | A kind of device and method for simulating the earth magnetism sudden turn of events |
-
2019
- 2019-04-16 CN CN201910302441.XA patent/CN109939358B/en active Active
Patent Citations (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1545985A (en) * | 2003-12-03 | 2004-11-17 | 宏 朱 | Magnetic heat treatment therapeutic apparatus for tumour |
| US8968173B2 (en) * | 2008-07-16 | 2015-03-03 | Frank Sivo | Methods to arrest cancer cell growth and proliferation using electromagnetic energy delivered via electromagnetic coil systems |
| CN202401062U (en) * | 2011-12-16 | 2012-08-29 | 陈克明 | Low-frequency electromagnetic-field cell treater |
| CN102653719A (en) * | 2012-04-28 | 2012-09-05 | 吉林大学 | Cell culture device capable of generating multiple magnetic fields and culture method |
| CN103272332A (en) * | 2013-06-02 | 2013-09-04 | 南方医科大学 | Tumor therapy equipment with non-ionization electromagnetic field exciting autonomous metabolism of human body and application thereof |
| CN104436441A (en) * | 2013-09-16 | 2015-03-25 | 韦兆祥 | Device of treating solid tumors |
| CN103520836A (en) * | 2013-10-14 | 2014-01-22 | 重庆大学 | Uniform pulsed magnetic field generator on basis of Helmholtz coil and IGBT (Insulated Gate Bipolar Transistor) module |
| KR20160134889A (en) * | 2015-05-13 | 2016-11-24 | 고려대학교 산학협력단 | Treatment Apparatus for cancer by electromagnetic fields |
| CN105169561A (en) * | 2015-09-01 | 2015-12-23 | 丁建民 | Cancer treatment device |
| WO2018017618A1 (en) * | 2016-07-18 | 2018-01-25 | Neotherma Oncology, Inc. | Systems and methods for targeted deep hyperthermia by time-shared rf inductive applicators |
| WO2018029569A1 (en) * | 2016-08-09 | 2018-02-15 | Politecnico Di Torino | Apparatus and method for the determination and the application of electromagnetic fields for influencing in vitro cell growth |
| CN108079441A (en) * | 2018-02-08 | 2018-05-29 | 四川大学华西医院 | A kind of Intelligent pulse electromagnetic apparatus and system for treating osteoporosis |
| CN108607162A (en) * | 2018-05-25 | 2018-10-02 | 浙江大学 | A kind of tumor suppression device of program control and use |
| CN109490973A (en) * | 2018-10-30 | 2019-03-19 | 吉林大学 | A kind of device and method for simulating the earth magnetism sudden turn of events |
| CN109459712A (en) * | 2018-12-05 | 2019-03-12 | 三峡大学 | Vector closed loop compensation formula triaxial magnetic field sensor probe based on Helmholtz coil |
Non-Patent Citations (1)
| Title |
|---|
| YUNZHONG NIE,等: "Low frequency magnetic fields enhance antitumor immune response against mouse H22 hepatocellular carcinoma", 《PLOS ONE》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110947099A (en) * | 2019-11-15 | 2020-04-03 | 郑州和济生物科技股份有限公司 | DC low-frequency pulse rotating magnetic field therapeutic equipment |
| CN112007277A (en) * | 2020-09-28 | 2020-12-01 | 四川大学华西医院 | Pulsed electromagnetic field device for breast cancer treatment |
| CN114019275A (en) * | 2021-10-28 | 2022-02-08 | 中国舰船研究设计中心 | Software-driven electromagnetic environment closed loop generation system and method |
| CN114796874A (en) * | 2022-05-10 | 2022-07-29 | 四川大学 | Magnetic field treatment device and method |
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