CN109939171B - Traditional Chinese medicine composition for treating cough after infection and application thereof - Google Patents
Traditional Chinese medicine composition for treating cough after infection and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating cough after infection, which comprises the following raw materials in parts by weight: 10 parts of mulberry leaf, 5-10 parts of almond, 10-12 parts of radix glehniae, 10-30 parts of prepared rehmannia root, 10 parts of ligusticum wallichii, 6 parts of mint, 10 parts of liquorice root-soaking earthworm, 5 parts of pummelo peel, 5-10 parts of loquat leaf and 10 parts of thunberg fritillary bulb. The traditional Chinese medicine composition is obtained by a large number of researches and optimizations on the basis of decades of clinical experiences of an inventor, can more effectively treat cough caused by wind-dryness invading lung and more effectively relieve the symptoms of cough, pharynx itch and foreign body sensation in pharynx of a patient in the daytime and at night.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating cough after infection and application thereof.
Background
Cough after infection is a disease in which cough persists and is difficult to heal as early symptoms subside after respiratory tract infection. It is usually manifested as irritative dry cough and a small amount of white sticky phlegm. The etiology of this disease is currently thought to be respiratory viral infection, with some cases of concurrent mycoplasma pneumoniae, chlamydia, or bacterial infection becoming a persistent post-infectious cough. The pathogenesis is unknown, and is thought to be related to airway inflammation, airway mucosal loss, airway hyperresponsiveness and the like. The treatment mainly comprises symptomatic treatment, can relieve cough symptoms, but is easy to repeat and has a long course of disease.
At present, the pathogenesis of cough after infection is not exact, foreign researches mostly relate to the pathogenesis and clinical tests of medicines, and domestic researches mostly lack large-scale epidemiological data on cough after infection, and at present, clinical reports mostly concentrate on the research on medicine curative effect comparison, less clinical treatment scale, more centers and large sample content. The medicine treatment has no specific medicine, mainly aims at treating diseases and relieving clinical symptoms, has larger difference of clinical curative effects of different medicines, and has adverse reactions such as somnolence, dizziness and the like on part of medicines.
In recent years, traditional Chinese medicine obtains a happy effect for treating cough after infection. Modern doctors believe that the disease characteristics of cough and irritant dry cough after infection are similar to those of 'dry cough' and 'wind cough' in the traditional Chinese medicine, and can be classified into the categories of 'dry cough' and 'wind cough'. The inventor summarizes the cough characteristics after infection in the south of Ling, and finds that the south of Ling is damp-heat, is easy to be affected by damp-heat and wind-heat, and the wind-heat dampness is lingering and difficult to cure, is easy to enter the interior to dissolve dryness and refine liquid to form phlegm, forms the pathogenesis of wind dryness attacking the lung and body fluid damaging the pathogen, and presents the discomfort of irritative dry cough, dry and itchy throat and the like. Clinically, a few irritant phlegm remains after treatment of dispelling wind, moistening dryness and reducing phlegm for some patients with cough caused by wind-dryness invading the lung, and the phlegm is difficult to eliminate, thereby causing troubles to the life of the patients. In previous researches, the inventor of the application finds that the modified mulberry-apricot decoction A (10 parts of mulberry leaf, 15 parts of adenophora stricta, 10 parts of cape jasmine fruit, 10 parts of fermented soybean, 15 parts of dwarf lilyturf tuber, 10 parts of rhizoma anemarrhenae, 15 parts of almond, 15 parts of thunberg fritillary bulb, 15 parts of loquat leaf and 10 parts of ligusticum wallichii) can effectively treat cough caused by wind-dryness invading lung type infection, and particularly can relieve symptoms of pharynx itch and foreign body sensation in pharynx, but further researches find that the treatment effect can be further improved.
Disclosure of Invention
Based on the above, the invention aims to overcome the defects of the prior art and provide the traditional Chinese medicine composition for treating post-infection cough, which can more effectively treat the wind-dryness lung type post-infection cough and more effectively relieve the symptoms of cough, pharynx itch and foreign body sensation in the pharynx of a patient in the daytime and at night.
In order to achieve the purpose, the invention adopts the technical scheme that:
a traditional Chinese medicine composition for treating cough after infection comprises the following raw materials in parts by weight: 10 parts of mulberry leaf, 5-10 parts of almond, 10-12 parts of radix glehniae, 10-30 parts of prepared rehmannia root, 10 parts of ligusticum wallichii, 6 parts of mint, 10 parts of liquorice root-soaking earthworm, 5 parts of pummelo peel, 5-10 parts of loquat leaf and 10 parts of thunberg fritillary bulb.
Preferably, the traditional Chinese medicine composition for treating cough after infection comprises the following raw materials in parts by weight: 10 parts of mulberry leaf, 5 parts of almond, 10 parts of radix glehniae, 10 parts of prepared rehmannia root, 10 parts of ligusticum wallichii, 6 parts of mint, 10 parts of liquorice bulb earthworm, 5 parts of pummelo peel, 5 parts of loquat leaf and 10 parts of thunberg fritillary bulb.
Preferably, the traditional Chinese medicine composition for treating cough after infection comprises the following raw materials in parts by weight: 10 parts of mulberry leaf, 10 parts of almond, 12 parts of radix glehniae, 15 parts of prepared rehmannia root, 10 parts of ligusticum wallichii, 6 parts of mint, 10 parts of liquorice bulb earthworm, 5 parts of pummelo peel, 10 parts of loquat leaf and 10 parts of thunberg fritillary bulb.
Preferably, the traditional Chinese medicine composition for treating cough after infection comprises the following raw materials in parts by weight: 10 parts of mulberry leaf, 10 parts of almond, 10 parts of radix glehniae, 30 parts of prepared rehmannia root, 10 parts of ligusticum wallichii, 6 parts of mint, 10 parts of liquorice bulb earthworm, 5 parts of pummelo peel, 10 parts of loquat leaf and 10 parts of thunberg fritillary bulb.
The invention also provides application of the traditional Chinese medicine composition for treating post-infection cough in preparation of a medicine for treating post-infection cough.
The traditional Chinese medicine composition for treating cough after infection can be used for preparing a medicine for treating cough after infection.
Another object of the present invention is to provide a medicament for treating cough after infection.
In order to achieve the purpose, the invention adopts the technical scheme that: a medicine for treating cough after infection comprises the traditional Chinese medicine composition for treating cough after infection.
Preferably, the medicament may further comprise a pharmaceutically acceptable carrier.
Preferably, the medicament is in an oral dosage form.
Preferably, the medicament is a granule, solution, tablet, capsule, powder, emulsion or suspension.
More preferably, the medicament is a granule.
Compared with the prior art, the invention has the beneficial effects that: the traditional Chinese medicine composition for treating cough after infection is obtained by the inventor through a large number of researches and optimizations on the basis of decades of clinical experiences, can more effectively treat cough after wind-dryness invading lung type infection, and more effectively relieve the symptoms of cough, pharynx itch and foreign body sensation in pharynx of patients in the daytime and at night.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Example 1
One embodiment of the traditional Chinese medicine composition for treating cough after infection comprises the following raw materials in parts by weight: 10 parts of mulberry leaf, 5 parts of almond, 10 parts of radix glehniae, 10 parts of prepared rehmannia root, 10 parts of ligusticum wallichii, 6 parts of mint, 10 parts of liquorice bulb earthworm, 5 parts of pummelo peel, 5 parts of loquat leaf and 10 parts of thunberg fritillary bulb.
Example 2
One embodiment of the traditional Chinese medicine composition for treating cough after infection comprises the following raw materials in parts by weight: 10 parts of mulberry leaf, 10 parts of almond, 12 parts of radix glehniae, 15 parts of prepared rehmannia root, 10 parts of ligusticum wallichii, 6 parts of mint, 10 parts of liquorice bulb earthworm, 5 parts of pummelo peel, 10 parts of loquat leaf and 10 parts of thunberg fritillary bulb.
Example 3
One embodiment of the traditional Chinese medicine composition for treating cough after infection comprises the following raw materials in parts by weight: 10 parts of mulberry leaf, 10 parts of almond, 10 parts of radix glehniae, 30 parts of prepared rehmannia root, 10 parts of ligusticum wallichii, 6 parts of mint, 10 parts of liquorice bulb earthworm, 5 parts of pummelo peel, 10 parts of loquat leaf and 10 parts of thunberg fritillary bulb.
Comparative example 1
In previous researches, the inventor of the application finds that the modified mulberry-apricot decoction A (10 parts of mulberry leaf, 15 parts of adenophora stricta, 10 parts of cape jasmine fruit, 10 parts of fermented soybean, 15 parts of dwarf lilyturf tuber, 10 parts of rhizoma anemarrhenae, 15 parts of almond, 15 parts of thunberg fritillary bulb, 15 parts of loquat leaf and 10 parts of ligusticum wallichii) can effectively treat cough caused by wind-dryness invading lung type infection, and particularly can relieve symptoms of pharynx itch and foreign body sensation in pharynx, but further researches find that the traditional Chinese medicine composition has a better treatment effect.
The comparative example studies the treatment effect of the modified mulberry-apricot decoction A on cough caused by wind-dryness invading lung.
Effect example 1
In this example, the treatment effect of the compositions of examples 1 to 3 and comparative example 1 on cough after infection was investigated.
(I) Experimental method
80 patients meeting the inclusion standard are randomly divided into 4 groups, and each group comprises 20 patients, wherein experimental groups 1 to 3 are respectively treated by the traditional Chinese medicine composition in examples 1 to 3 in combination with western medicine compound methoxamine capsules and montelukast sodium, a control group is treated by the prescription of the flavored mulberry apricot decoction A in the comparative example 1 in combination with western medicine compound methoxamine capsules and montelukast sodium, a western medicine group is treated by the compound methoxamine capsules and the montelukast sodium, the treatment medication of each group is 1 week, the change of cough visual simulation scores, cough symptom scores and traditional Chinese medicine symptom scores of 4 th day and 8 th day of each group is observed, and the curative effect and the safety of each group are evaluated. The using method of the composition comprises the following steps: decocting with water to 200ml, and taking warm once after breakfast and supper.
1. Patient inclusion criteria were:
(1) the age is 18-70 years old;
(2) the duration time is more than or equal to 3 weeks and less than or equal to 8 weeks according to the diagnosis standard of cough after infection;
(3) those who meet the diagnostic criteria of wind-dryness attacking the lung type cough.
2. Patient exclusion criteria:
(1) those who do not meet the criteria for post-infection cough;
(2) patients who do not meet the diagnostic criteria of traditional Chinese medicine;
(3) refusing to participate in the test;
(4) patients with prior test drug allergy history;
(5) pregnant and lactating women;
(6) complicated with serious basic diseases, such as insufficiency of the liver and kidney;
(7) the former patients with cough caused by chronic diseases such as lung cancer, pulmonary tuberculosis, asthma, etc.;
(8) diseases caused by respiratory tract infection and similar to cough after infection, such as CVA, acute and chronic bronchitis, upper airway cough syndrome, etc.;
3. standards for rejection, shedding and termination of experiments
The reason and time for the subject to terminate the clinical trial were recorded in detail. And eliminating any 1 standard person in the following 6 items:
(1) leading to serious adverse events;
(2) in the process of taking the medicine, the subject has the original serious progress of the disease condition and is combined with other serious diseases or serious adverse reactions;
(3) the observed subject has low compliance and is not in compliance with the doctor;
(4) the subject quits by himself due to personal factors;
(5) other drugs are taken by the patient during the treatment period, and study results are interfered;
(6) those who are missed or unable to follow up.
(II) evaluation index and evaluation standard of curative effect
1. Safety index
Blood analysis, liver function (AST, ALT), and renal function (serum creatinine), before and after treatment.
2. Index of therapeutic efficacy
(1) Degree of improvement and efficiency;
(2) cough visual analogue score (VAS score);
(3) cough symptom score (table 1);
(4) TCM syndrome integration (Table 2).
3. Criteria for evaluating therapeutic effects
(1) Criteria for judging cough curative effect
Referring to the cough symptom score table in "guideline for diagnosing and treating cough" in 2015, the following score table (table 1) was used for the subject. Before treatment, on the 4 th and 8 th days after the start of treatment, the observation subjects were monitored for symptoms, and scored and the treatment effect was judged according to the tables.
TABLE 1 cough symptom score-chart (points)
The treatment effect judgment standard is as follows: cough symptoms completely disappeared (score decreased to 0 after treatment); the effect is shown: cough symptoms were significantly reduced (score reduction > 1 point after treatment); the method has the following advantages: cough symptoms were reduced (score was reduced by 1 point after treatment); and (4) invalidation: there was no significant improvement in cough symptoms (score did not change or even increased after treatment).
(2) Visual simulation scoring
The scale marks of 0, 1 and 2-10 cm are made by adopting a linear scoring method, wherein the 0 scale represents no cough, and the 10 scale represents the heaviest cough degree. The larger the number, the most severe cough was indicated and was self-scored by the patient for longitudinal comparisons before and after treatment. All patients were scored before treatment, on day 4 and day 8 after the start of treatment, respectively.
(3) Chinese medicine symptom curative effect judgment standard
According to the clinical research guiding principle of new traditional Chinese medicine, according to the characteristics of the syndrome of traditional Chinese medicine, the method integrates cough, foreign body sensation in pharynx, pharyngalgia, pharynx itch and dry pharynx, and the degree of severity of symptoms is divided into 4 grades of 0, plus and minus, and the scores are respectively and correspondingly calculated by 0, 1, 2 and 3 minutes to quantify the integral.
TABLE 2 hierarchical quantization standard (score) for observation index of TCM syndrome
The traditional Chinese medicine syndrome curative effect index is (integration before treatment-integration after treatment)/integration before treatment x 100%
Firstly, healing: clinical symptoms and physical signs disappear or basically disappear, and n percent is more than or equal to 95 percent;
secondly, effect is displayed: clinical symptoms and physical signs are obviously improved, and n is more than or equal to 70 percent and less than 95 percent;
③ effective: the clinical symptoms and physical signs are improved, and n is more than or equal to 30 percent and less than 70 percent;
fourthly, invalidation: clinical symptoms and physical signs are not obviously improved or even aggravated, and n percent is less than 30 percent;
the fifth is recovery, obvious effect and effective, which are called total effective rate.
4. Data processing and statistical analysis
The database was organized using Excel, statistical analysis was performed using SPSS20.0 statistical software, and all data are expressed as x ± S. The measured data are subjected to variance analysis or t test when being in accordance with normality, the comparison of the counting data is subjected to chi-square test, the rank sum test is carried out on the grade data and the data which are not in accordance with normal distribution, and the difference P <0.05 has statistical significance.
(III) results of the experiment
The safety index detection results show that after treatment, the liver and kidney functions of the experimental groups 1-3 are rechecked, liver and kidney dysfunction is avoided, gastrointestinal reactions such as nausea, vomiting, abdominal pain and diarrhea and discomfort such as rash do not occur to all patients taking the medicines, the control group does not drop and remove cases, and 7 western medicines are removed after self-stopping due to discomfort such as dizziness, somnolence and the like. Specific data is omitted.
Through analysis, the patients in each group have no statistical difference in sex, age and disease course, and have comparability.
1. Visual simulation score comparison results
All groups of vision simulation scores before treatment, and data variance is uniform through the check of the variance; through analysis of variance, the differences of the visual simulation scores of the three groups before treatment have no statistical significance (P is more than 0.05), and the visual simulation scores have comparability. The results of the visual simulation scores for each group after treatment are shown in table 3:
table 3 comparison of visual simulation scores for each group after treatment (score,
)
the results show that the experimental groups 1-3 and the control group can effectively improve the cough symptom compared with the western medicine group. Analysis of variance was designed using repeated measurements. According to detection, as for a spherical detection result, P is less than 0.05, the spherical distribution hypothesis is not satisfied, Greenhouse-Geisser is selected in the detection of the main body internal effect, the time point F is 50.00, P is 0.000, and the difference of the visual simulation scores of all the time points has statistical significance; and the P of the time points and different groups is less than 0.05, which shows that the VAS scores of all groups gradually decrease along with the passage of treatment time, and the decrease speed of the experimental group is faster than that of the control group and the western medicine group.
2. Cough symptom score comparison results
Before treatment, the daytime cough symptom scores of all groups do not conform to normal distribution, and through the rank sum test, P is more than 0.05, and the difference has no statistical significance and is comparable; before treatment, the integration of the symptoms of the cough at night in each group accords with normal distribution, P is more than 0.05 through variance analysis, the difference has no statistical significance, and the method has contrast.
The comparison results after daytime cough symptom score treatment for each group are shown in table 4, and the comparison results after nighttime cough symptom score treatment for each group are shown in table 5:
table 4 comparison of daytime cough symptom scores for each group after treatment (score,
)
table 5 comparison of the night cough symptom scores for each group after treatment (score,
)
the effect of treatment time points and different groups on daytime and nighttime cough symptom scores are shown in table 4. Each group of data is subjected to repeated measurement and design variance analysis, the football-shaped distribution assumption is detected, multivariate analysis or freedom degree adjustment is adopted, Greenhouse-Geisser is selected in the test of the main body internal effect, the time point P is less than 0.05, the day and night cough symptom integral difference of each time point has statistical significance, and the day and night symptom integral is gradually reduced along with the time. The P of the packet is more than 0.05, the time and the packet have no interaction effect, and the effect of the time factor is not different from packet to packet. Univariate variance analysis is carried out on the western medicine groups, P is more than 0.05, and the Greenhouse-Geisser result is combined, so that the integral of the daily and nighttime cough symptoms of the western medicine groups is reduced to some extent along with the time, but the difference has no statistical significance.
At fixed time points, multivariate analysis of variance was performed on each group of night cough symptom integrals. Before treatment, the score of cough symptoms of each group is greater than 0.05, and the difference is not statistically abnormal and is comparable. On day 4 of treatment, the group comparisons P >0.05, with no statistical significance for the differences; on the 8 th day of treatment, comparison of each group shows that integral difference of cough symptoms at night of each group has statistical significance, further pairwise comparison is carried out, an SNK method is adopted, experimental groups are 1-3, a control group is compared with a western medicine group, and P is less than 0.05; compared with the control group, P is more than 0.05, which shows that the experimental groups 1-3 and the control group can relieve day and night cough symptoms to the same extent, and the relieving degree is more obvious than that of the western medicine group.
According to the judgment standard of the western medicine curative effect, the total effective rate of each group on the treatment day 4 is shown in table 6, and the total effective rate of each group on the treatment day 8 is shown in table 7:
table 6 comparison of total effective rate of each group for treating cough on day 4 [ case (%) ]
*: compared with the control group and the western medicine group, P is less than 0.05
Table 7 comparison of total effective rate of each group for treating cough on day 8 [ case (%) ]
*: compared with western medicine group, P is less than 0.05
According to the judgment standard of the western medicine curative effect, the experimental group 3 heals 0 cases, has 11 significant effects, 3 effective cases and 1 ineffective case on the treatment day 4, the total effective rate is 87.5 percent, and the total significant efficiency is 68.8 percent. The control group heals 0 cases, has obvious effect of 7 cases, has 10 cases and 3 cases, has total effective rate of 85 percent and total effective rate of 35 percent. The western medicine composition cures 0 cases, has 0 obvious effect, 8 effective cases and 5 ineffective cases, the total effective rate is 61.54 percent, and the total effective rate is 0 percent. The effective rate of each group is proved by chi fang test, P is more than 0.05, the difference has no statistical significance, the use rank sum test of each group of grade data, and P is more than 0.05, which shows that the curative effect of each group has no significant difference. However, the results show that the significant efficiency of the experimental group 3 on the 4 th day is less than 0.05 compared with the control group and the western medicine group, which indicates that the cough onset time is faster after the experimental group 3 treats the infection.
According to the judgment standard of the western medicine curative effect, 4 experimental groups in the experimental group 3 on the 8 th day of treatment cure, 10 effective cases, 1 effective case and 1 ineffective case, the total effective rate is 93.75%, the effective rate is 87.5%, and the cure rate is 25%; the control group is cured for 3 cases, the effective rate is 12 cases, the effective rate is 4 cases, the ineffective rate is 1 case, the total effective rate is 95%, the effective rate is 75%, and the cure rate is 25%; the western medicine composition cures 0 case, has obvious effect of 7 cases, has 3 cases and 7 cases of no effect, has the total effective rate of 76.7 percent, the obvious effective rate of 53.8 percent and the cure rate of 0 percent. The effective rate of each group is tested by chi fang, P is less than 0.05, grade data of each group is tested by rank sum, P is less than 0.05, and the difference has statistical significance, which indicates that the difference of the curative effect of each group on the 8 th day of treatment has statistical significance. The curative effects of each group were compared pairwise, Bonferroni correction was performed on the test level, P <0.05, and the differences were statistically significant. Wherein, the curative effect of the experimental group 1-3 is compared with that of the control group, the difference has no statistical significance, and the experimental group and the control group both have good curative effect on PIC. The curative effects of the experimental groups 1-3 and the control group are respectively compared with the western medicine group, and the Mann-whitney test shows that the P is less than 0.05, the difference has statistical significance, and the experimental groups 1-3 have better curative effect than the western medicine group. The cure rate of the experimental groups 1-3 on the 8 th day is obviously different from that of the western medicine group (P is less than 0.05) and is also higher than that of the control group by 10 percent, but the obvious difference is not seen, which indicates that the experimental group possibly has a higher curative effect trend than the control group in treating the cough caused by wind-dryness invading lung type infection, and the sample can be further expanded for research in the future.
3. Integral comparison of Chinese medicine symptoms
Before treatment, the total integral of each group of symptoms is compared to obtain P more than 0.05, and the difference has no statistical significance, which indicates that the total integral of each group of symptoms has comparability.
The total integral comparison results of the traditional Chinese medicine symptoms after the treatment of each group are shown in table 8, the integral comparison results of cough, pharynx itch, dry throat and foreign body sensation in the pharyngeal portion on the 4 th day of the treatment of each group are shown in table 9, and the integral comparison results of cough, pharynx itch, dry throat and foreign body sensation in the pharyngeal portion on the 8 th day of the treatment of each group are shown in table 10:
table 8 total integral comparison of chinese medical symptoms after each group of treatments (score,
)
table 9 total score comparison of symptoms on day 4 of treatment for each group (score,
)
table 10 total score comparison of symptoms on day 8 of treatment for each group (score,
)
the results show that compared with a control group and a western medicine group, the experimental group 1-3 can effectively relieve the cough, and is obviously superior to western medicine groups in the aspects of relieving the daytime cough, improving the dry throat, foreign body sensation in the throat and the like.
According to the curative effect standard of Chinese medicine syndrome, the total effective rate of each group on the treatment day 4 is tested by chi fang, P is more than 0.05, and the difference has no statistical significance. On the 8 th day of treatment, the total effective rate of each group is proved by chi fang test, P is less than 0.05, and the difference of the curative effect of each group has statistical significance. The curative effects of the groups are compared pairwise, and the differences have statistical significance when the P is less than 0.05 by Bonferroni correction. Wherein, the curative effect of the experimental group 1-3 is compared with that of the control group, P is more than 0.05, and the difference has no statistical significance. Compared with the western medicine group and the control group, the experimental groups 1 to 3 and the control group have P <0.05 and have statistical significance through Mann-whitney test, which indicates that the curative effects of the experimental groups 1 to 3 and the control group are better than those of the western medicine group.
According to the therapeutic effect standard of the traditional Chinese medicine symptoms, the total effective rate of each group on the treatment day 4 is shown in table 11, and the total effective rate of each group on the treatment day 8 is shown in table 12:
table 11 comparison of total effective rate on treatment day 4 of each group [ case (%) ]
Table 12 comparison of total effective rate on day 8 of treatment [ examples (%) ]
In conclusion, the experimental groups 1-3 (the traditional Chinese medicine composition of the invention) and the control group (the modified mulberry-apricot decoction A formula) have exact curative effects on cough caused by wind-dryness invading lung type infection, the clinical curative effects are as high as more than 90%, and the clinical application values are clear.
The obvious effect of the traditional Chinese medicine composition on the treatment day 4 is obviously higher than that of the prescription A of the modified mulberry-apricot decoction (P <0.05), and the traditional Chinese medicine composition has shorter and faster onset time and higher obvious effect on improving cough symptoms.
Although the total effective rate of the prescription A of the modified mulberry-apricot decoction on the 8 th day of treatment is higher than that of the traditional Chinese medicine composition, the combined cure rate and the significant effect rate are higher than those of the prescription A of the modified mulberry-apricot decoction, and the fact that the total effective rate is lower due to fewer studied cases can be inferred, and the problem can be further researched in future researches.
In the aspect of symptom improvement, compared with the prescription A of the modified mulberry-apricot decoction, the traditional Chinese medicine composition can effectively relieve the symptoms of cough, pharynx itch and foreign body sensation in pharynx during the day and at night, and the score of cough symptom score and cough life quality questionnaire score after treatment is obviously superior to that of the modified mulberry-apricot decoction.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for treating cough after infection is characterized by comprising the following raw material medicines in parts by weight: 10 parts of mulberry leaf, 5-10 parts of almond, 10-12 parts of radix glehniae, 10-30 parts of prepared rehmannia root, 10 parts of ligusticum wallichii, 6 parts of mint, 10 parts of liquorice root-soaking earthworm, 5 parts of pummelo peel, 5-10 parts of loquat leaf and 10 parts of thunberg fritillary bulb.
2. The traditional Chinese medicine composition for treating cough after infection according to claim 1, which is characterized by comprising the following raw material medicines in parts by weight: 10 parts of mulberry leaf, 5 parts of almond, 10 parts of radix glehniae, 10 parts of prepared rehmannia root, 10 parts of ligusticum wallichii, 6 parts of mint, 10 parts of liquorice bulb earthworm, 5 parts of pummelo peel, 5 parts of loquat leaf and 10 parts of thunberg fritillary bulb.
3. The traditional Chinese medicine composition for treating cough after infection according to claim 1, which is characterized by comprising the following raw material medicines in parts by weight: 10 parts of mulberry leaf, 10 parts of almond, 12 parts of radix glehniae, 15 parts of prepared rehmannia root, 10 parts of ligusticum wallichii, 6 parts of mint, 10 parts of liquorice bulb earthworm, 5 parts of pummelo peel, 10 parts of loquat leaf and 10 parts of thunberg fritillary bulb.
4. The traditional Chinese medicine composition for treating cough after infection according to claim 1, which is characterized by comprising the following raw material medicines in parts by weight: 10 parts of mulberry leaf, 10 parts of almond, 10 parts of radix glehniae, 30 parts of prepared rehmannia root, 10 parts of ligusticum wallichii, 6 parts of mint, 10 parts of liquorice bulb earthworm, 5 parts of pummelo peel, 10 parts of loquat leaf and 10 parts of thunberg fritillary bulb.
5. Use of the traditional Chinese medicine composition for treating cough after infection according to any one of claims 1 to 4 in preparation of a medicine for treating cough after infection.
6. A medicament for treating cough after infection, which is characterized by comprising the traditional Chinese medicine composition for treating cough after infection as claimed in any one of claims 1-4.
7. The medicament for treating cough after infection according to claim 6, wherein the medicament further comprises a pharmaceutically acceptable carrier.
8. The medicament for treating cough after infection according to claim 6 or 7, wherein the medicament is an oral dosage form.
9. The medicament for treating cough after infection according to claim 8, wherein the medicament is granule, solution, tablet, capsule, powder, emulsion or suspension.
10. The medicament for treating cough after infection according to claim 9, wherein the medicament is a granule.
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| CN102772652A (en) * | 2012-07-12 | 2012-11-14 | 严中明 | Traditional Chinese medicine composition for treating cough and preparation method thereof |
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| "刘琼治疗亚急性咳嗽经验";黄琦玢 等;《河南中医》;20181231;40-41 * |
| "国医大师李振华教授临证验案举隅";郭淑云 等;《中医研究》;20131231;1012-1015 * |
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