CN109925912B - Equipment for uniformly mixing liquid preparation and application thereof - Google Patents

Abstract

The invention provides equipment for uniformly mixing liquid preparations, which comprises a sample feeding mechanism and a mixing mechanism, wherein the sample feeding mechanism comprises an inner vehicle for placing the liquid preparations, the mixing mechanism comprises a rotating cage body, and the rotating cage body is matched with the inner vehicle and used for rotatably mixing the liquid preparations placed on the inner vehicle. The invention further provides a use method of the equipment for uniformly mixing the liquid preparation. According to the equipment for uniformly mixing the liquid preparation and the application thereof, provided by the invention, manual tray shaking operation is replaced by automatic rotating mechanical equipment, so that the uniform mixing of products in multiple trays can be realized, and the equipment is convenient to operate, reliable in performance, safe and stable, and very worthy of popularization and application.

Description

Equipment for uniformly mixing liquid preparation and application thereof

Technical Field

The invention belongs to the technical field of liquid preparation mixing, relates to equipment for uniformly mixing liquid preparations and application thereof, and particularly relates to equipment for uniformly mixing turbid liquid or emulsion and application thereof.

Background

The liquid preparation injection is added with a certain amount of surfactant polysorbate-80 as a solubilizer according to the requirements of a process formula, wet heat sterilization is needed after the full amount of liquid medicine is encapsulated into a semi-finished product, but the physical property of polysorbate-80 shows that after the polysorbate-80 is heated to 93 ℃ (epiphyllic point), hydrogen bonds formed between polysorbate-80 and water in an aqueous solution are broken, the solubility of polysorbate-80 is sharply reduced and separated out to form a layered product (similar to sugar dissolution), although the process is reversible after cooling, the process of natural re-dissolution is very slow, the stability of the product in the state can be influenced, and the layered product can be mistakenly judged as an unqualified product when a full-automatic light inspection machine is used for visible foreign matter inspection, so that the product loss is caused.

At present, the production workshop adopts a mode of manually turning over a turnover table to uniformly mix sterilized products so as to promote the redissolution of polysorbate-80. However, this method is labor-intensive, and the mixing effect is greatly affected by different tray-shaking force and mode of each person, so it is necessary to design a device for mixing liquid preparation instead of manual tray-shaking operation.

Disclosure of Invention

In view of the above disadvantages of the prior art, an object of the present invention is to provide a device for blending liquid preparations and an application thereof, which are used for blending products in multiple batches, and the device is convenient to operate, reliable in performance, safe and stable.

In order to achieve the above and other related objects, a first aspect of the present invention provides an apparatus for uniformly mixing a liquid preparation, including a sample injection mechanism and a mixing mechanism, where the sample injection mechanism includes an inner vehicle for placing the liquid preparation, and the mixing mechanism includes a rotating cage, and the rotating cage is matched with the inner vehicle for rotatably mixing the liquid preparation placed on the inner vehicle.

Preferably, the sampling mechanism further comprises a tank car, and the tank car is positioned below the inner car and used for carrying the inner car.

More preferably, the tank wagon is a trolley.

More preferably, a plurality of direction wheels are arranged below the loading platform of the tank car. The direction wheels can push the tank car to move.

Further preferably, the number of the direction wheels is 4, and the direction wheels comprise 2 universal wheels and 2 directional wheels, the universal wheels are symmetrically arranged below the loading platform close to the handle of the tank car, and the directional wheels are symmetrically arranged below the loading platform far away from the handle of the tank car.

More preferably, outer guide rails are arranged on two sides above the loading platform of the tank car, rail wheels are arranged on two sides of the bottom of the inner car, and the outer guide rails are matched with the rail wheels and used for placing the inner car. The outer guide rail is matched with the track wheels, namely, the track wheels can be arranged in the outer guide rail to roll, so that the inner vehicle can be driven to move.

Preferably, the sampling mechanism further comprises an interlocking switch, and the inner vehicle is detachably connected with the tank wagon through the interlocking switch.

More preferably, the interlock switch is card sheath formula mechanical interlock switch, the interlock switch is including first card sheath spare, second card sheath spare, first card sheath spare is located on the interior car, second card sheath spare is located on the tank wagon, detachable spacing joint between first card sheath spare and the second card sheath spare.

Particularly, when the first clamping sheath piece and the second clamping sheath piece are in limiting clamping connection, the movement of the inner vehicle on the tank wagon can be limited, and the inner vehicle is prevented from sliding off the tank wagon. The first sheath clamping piece and the second sheath clamping piece can be clamped through manually stirring the handle.

Preferably, be equipped with a plurality of layering supports in the interior car from top to bottom, every a plurality of week carousel has been placed to in the layering support, the turnover dish is used for placing liquid preparation.

Preferably, the inner vehicle is hollow and open at the top. The whole inner vehicle is a cuboid.

More preferably, the turnover table is rectangular parallelepiped, hollow and open at the top.

More preferably, a cushion is arranged in the inner vehicle, and the cushion is arranged between the turnover plates in an auxiliary mode.

Preferably, both ends of the inner vehicle are respectively provided with an openable net fence. The inner circumference turntable is used for blocking and fixing the inner circumference turntable of the layered bracket on the inner vehicle.

Preferably, the mixing mechanism further comprises a frame, the frame is hollow, a frame opening is formed in one side wall of the frame, a rotating cage is arranged in the frame, one end of the rotating cage is communicated with the frame opening, and the rotating cage is matched with the inner vehicle through the frame opening.

More preferably, the frame opening is provided with an openable and closable safety door.

More preferably, a door limit switch is arranged above the frame opening. The lower part of the door limit switch is positioned in the safety door and is contacted with the safety door. The door limiting switch is connected with the controller and used for sending a safety door opening and closing signal of the door limiting switch to the controller.

More preferably, a compressing knob is arranged above the opening of the frame, a compressing plate is arranged at the top of the rotating cage body, the compressing knob is connected with the compressing plate, the compressing knob drives the compressing plate to ascend and descend through rotation, and the rotating cage body is used for covering and compressing the entering inner periphery turntable of the layered support on the inner car.

Further preferably, the pressing knob is rotated by a wrench, and the pressing plate is driven by mechanical threads to lift up and down. The degree of compression of the compression plate on the turnover disc is sensed through the rotation force of the wrench.

More preferably, the bottom of the frame opening is provided with a baffle, two ends of the baffle are provided with limiting holes, and the limiting holes are matched with one end of the outer guide rail on the tank car, which is used for inputting the inner car into the rotating cage body.

The spacing hole with the outer guide rail is used for pushing the interior car into the one end phase-match of rotatory cage body on the tank wagon means, and the front end of outer guide rail can insert spacing downthehole fixing, and the in-process that the interior car of being convenient for pushed into rotatory cage body avoids the tank wagon roll to lead to the interior car to drop.

More preferably, the bottom in the rotating cage body is provided with an inner guide rail, and the inner guide rail is matched with the rail wheels at the bottom of the inner vehicle. The inner guide rail is matched with the rail wheels at the bottom of the inner vehicle, namely, the rail wheels can be arranged in the inner guide rail to roll, so that the inner vehicle can be conveniently pushed to enter the rotating cage body.

More preferably, a proximity switch is provided on the frame. The proximity switch is a positioning switch.

More preferably, a support bottom plate is arranged in the frame, and the rotary cage body is placed on the support bottom plate.

More preferably, a control part is provided at one side of the frame opening, and the control part comprises the following parts:

the power switch is externally connected with a power supply and used for supplying power to equipment;

an alarm;

the emergency stop switch is used for emergently closing the mixed operation of the rotating cage body;

the display screen is used for inputting mixed operation information to the rotating cage body;

a printer;

and the controller is respectively connected with the display screen, the alarm and the printer, and is used for receiving the mixed operation information signal sent by the display screen, sending a mixed operation finishing signal to the alarm and sending a signal for printing the mixed operation information to the printer.

Further preferably, the controller is a PLC controller which is conventionally used. Those skilled in the art will appreciate that the calculation, comparison, judgment and instruction output processes of the controller can be implemented by using integrated circuit modules, programmable logic devices, other hardware or installing corresponding software modules in the prior art. For example, specifically, the controller is a PLC controller model S7-200CN manufactured by SIEMENS Siemens Inc.

In particular, the control means have stored thereon a computer program which, when executed, enables a rotating hybrid operation of the rotating cage in the hybrid means.

Preferably, rotatory cage body is including a plurality of spacing gyro wheels that set gradually along interior car advance kind direction, rotatory cage is equipped with outward and rotates gyro wheel, transmission supporting wheel, gear motor, converter, it is located the middle part of rotatory cage body to rotate the gyro wheel, rotate gyro wheel, transmission supporting wheel, gear motor and connect through gear coupling transmission in proper order, the converter is connected with gear motor and is used for sending rotation signal to gear motor, gear motor receives the rotation signal back rotation that the converter sent. The frequency converter can adjust the rotating speed of the rotating cage body.

More preferably, the frequency converter is connected with the controller, and the frequency converter is used for receiving the rotation signal sent by the controller.

More preferably, the frequency converter is a conventionally used frequency converter. Specifically, the frequency converter is an ATV310HU30N4A type frequency converter manufactured by Schneider.

More preferably, a limiting block is arranged on the limiting roller. The limiting block is in contact with the proximity switch. In the rolling process of the limiting idler wheel, the limiting block can judge which position the rotating cage body rotates to when the limiting block rotates to be close to the proximity switch.

Further preferably, the limit block is located at an edge of the rotating roller.

More preferably, a base is arranged at the lower part of the transmission supporting wheel.

More preferably, the frequency converter is placed in a distribution box.

In a second aspect, the invention provides the use of the apparatus described above in the mixing of liquid formulations and injections.

Preferably, the liquid preparation injection is a pulse-activating injection added with a surfactant as a solubilizer.

More preferably, the surfactant is polysorbate-80.

The third aspect of the invention provides a use method of equipment for uniformly mixing liquid preparations, which comprises the following steps:

1) in a sample injection mechanism, the liquid preparation is put into the inner vehicle;

2) then, after the inner vehicle is pushed into the rotating cage body, the rotating cage body is started to rotate and mix;

3) taking out the inner vehicle from the rotating cage body after rotating and mixing, and opening the inner vehicle to take out the uniformly mixed liquid preparation.

Preferably, in step 1), the inner vehicle is placed on a tank car.

Preferably, in step 1), the liquid formulation is placed in an epicyclic disc placed in a stratified box of an inner vehicle.

More preferably, the liquid formulation is placed in the turnaround tray in an amount of 20 ml ampoules 170 per tray or 10 ml ampoules 270 per tray.

Preferably, in step 1), two ends of the inner vehicle are respectively provided with an openable net fence.

More preferably, the mesh aperture of the net fence is smaller than the opening of the peripheral disc. The leakage of the turnover disc is prevented.

Preferably, in step 2), the inner cart is pushed into the rotating cage through the frame opening.

Preferably, in the step 2), the rotating speed of the rotating cage body is 9-11 circles/min. More preferably, the rotating speed of the rotating cage body is 10 circles/min.

Preferably, in the step 2), the rotating speed of the limiting roller in the rotating cage body is 9-11 circles/min. More preferably, the rotating speed of the limiting roller in the rotating cage body is 10 circles/min.

As mentioned above, the equipment for uniformly mixing the liquid preparation and the application thereof provided by the invention have the following beneficial effects:

(1) according to the equipment for uniformly mixing the liquid preparation and the application thereof, the motor drives the rotating cage body in the equipment to rotate, so that the product is uniformly mixed in a rotating manner, the use is convenient, the operation is easy to control, and the popularization and the application are very worthy.

(2) According to the equipment for uniformly mixing the liquid preparation and the application thereof, provided by the invention, manual tray shaking operation is replaced by automatic rotating mechanical equipment, so that the uniform mixing of products in multiple trays can be realized, and the equipment is convenient to operate, reliable in performance, safe and stable.

(3) The invention provides equipment for uniformly mixing liquid preparations and application thereof, which realize the rotation of products in the equipment by driving a gear to rotate so as to achieve the aim of uniformly mixing liquid medicines. In addition, the motor is controlled by the frequency converter, so that the rotating and uniform mixing at different rotating speeds can be realized.

Drawings

Fig. 1 is a perspective view showing the overall structure of an apparatus for mixing a liquid preparation according to the present invention.

Fig. 2 is a schematic side view of an apparatus for mixing a liquid preparation according to the present invention.

Fig. 3 is a schematic front structural view of an apparatus for mixing liquid preparation according to the present invention.

Fig. 4 is a schematic front structural diagram of a mixing mechanism in the device for uniformly mixing the liquid preparation.

Fig. 5 is a schematic side view of a sample injection mechanism in the apparatus for uniformly mixing liquid preparations according to the present invention.

Fig. 6 is a schematic front structural diagram of a sample injection mechanism in the device for uniformly mixing the liquid preparation according to the present invention.

Reference numerals

1 sample introduction mechanism

11 inner vehicle

111 layered scaffold

112 net fence

113 track wheel

12-tank vehicle

121 outer guide rail

13 interlock switch

2 mixing mechanism

21 frame

211 supporting base plate

22 rotating cage

221 position-limiting roller

2211 stop block

222 rotating roller

223 driving support wheel

224 gear motor

225 frequency converter

226 base

227 inner guide rail

23 opening of frame

24 safety door

25 pressing knob

26 pressure strip

27 baffle plate

271 limit hole

28 control unit

281 power switch

282 alarm

283 emergency stop switch

284 display screen

285 printer

Detailed Description

The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will become apparent to those skilled in the art from the present disclosure.

Please refer to fig. 1 to 6. It should be understood that the structures, ratios, sizes, and the like shown in the drawings and described in the specification are only used for matching with the disclosure of the specification, so as to be understood and read by those skilled in the art, and are not used to limit the conditions under which the present invention can be implemented, so that the present invention has no technical significance, and any structural modification, ratio relationship change, or size adjustment should still fall within the scope of the present invention without affecting the efficacy and the achievable purpose of the present invention. In addition, the terms "upper", "lower", "left", "right", "middle" and "one" used in the present specification are for clarity of description, and are not intended to limit the scope of the present invention, and the relative relationship between the terms and the terms is not to be construed as a scope of the present invention.

As shown in fig. 1 to 6, the present invention provides a device for uniformly mixing a liquid preparation, which comprises a sample injection mechanism 1 and a mixing mechanism 2, wherein the sample injection mechanism 1 comprises an inner vehicle 11 for placing the liquid preparation, the mixing mechanism 2 comprises a rotating cage 22, and the rotating cage 22 is matched with the inner vehicle 11 for rotatably mixing the liquid preparation placed on the inner vehicle 11.

In a preferred embodiment, as shown in fig. 1-3, the sample feeding mechanism 1 further comprises a tank car 12, and the tank car 12 is located below the inner car 11 for carrying the inner car 11.

Further, as shown in FIGS. 1-3, the tank car 12 is a hand truck.

Further, a plurality of direction wheels are arranged below the loading platform of the tank car 12. The direction wheels can push the tank car 12 to move. Specifically, the direction wheels are 4 in number and comprise 2 universal wheels and 2 directional wheels, the universal wheels are symmetrically positioned below the object carrying platform close to the handle of the tank wagon 12, and the directional wheels are symmetrically positioned below the object carrying platform far away from the handle of the tank wagon 12.

Further, as shown in fig. 1-3, outer guide rails 121 are disposed on two sides above the loading platform of the tank car 12, rail wheels are disposed on two sides of the bottom of the inner car 11, and the outer guide rails 121 are matched with the rail wheels for placing the inner car 11. The rail wheels can be arranged in the outer guide rail 121 to roll, so that the inner vehicle 11 can be driven to move.

In a preferred embodiment, as shown in fig. 3, the sample feeding mechanism 1 further includes an interlock switch 13, and the inner cart 11 is detachably connected to the tank cart 12 through the interlock switch 13.

Further, interlock switch 13 is card sheath formula mechanical interlock switch, interlock switch 13 is including first card sheath spare, second card sheath spare, first card sheath spare is located on interior car 11, second card sheath spare is located on tank wagon 12, detachable spacing joint between first card sheath spare and the second card sheath spare.

Specifically, when the first sheath clamping member and the second sheath clamping member are in limited clamping, the movement of the inner vehicle 11 on the tank wagon 12 can be limited, and the inner vehicle 11 is prevented from sliding off the tank wagon 12. The first sheath clamping piece and the second sheath clamping piece can be clamped through manually stirring the handle.

In a preferred embodiment, as shown in fig. 5-6, a plurality of layered supports 111 are provided in the inner vehicle 11 from top to bottom, and a plurality of rotating discs are placed in the layered supports 111, and the rotating discs are used for placing liquid preparations.

Further, the turnover table is cuboid, hollow and open-topped.

Further, a soft cushion is arranged in the inner vehicle 11, and the soft cushion is arranged between the turnover plates in an auxiliary mode. The cushion prevents hard collision, and the cushion ampoule receives the impact, can weaken the clash in rotatory process.

In a preferred embodiment, the interior compartment 11 is hollow and open-topped, as shown in FIGS. 5-6. The whole inner vehicle 11 is a cuboid.

In a preferred embodiment, as shown in fig. 1-4, the inner vehicle 11 is provided with net rails 112 at both ends thereof, which can be opened and closed. For blocking and fixing the inner periphery turntable of the layered bracket 111 on the inner vehicle 11.

In a preferred embodiment, as shown in fig. 1-3, the mixing mechanism 2 further includes a frame 21, the frame 21 is hollow, and a frame opening 23 is formed on a side wall of the frame 21, a rotating cage 22 is disposed in the frame 21, one end of the rotating cage 22 is communicated with the frame opening 23, and the rotating cage 22 is matched with the inner vehicle 11 through the frame opening 23.

Further, as shown in fig. 1-2, the frame opening 23 is provided with an openable and closable safety door 24. A door limit switch is arranged above the frame opening 23, and the lower part of the door limit switch is positioned in the safety door 24 and is contacted with the safety door 24. The door limiting switch is connected with the controller and used for sending a safety door opening and closing signal of the door limiting switch to the controller. The safety door 24 is a single door. When the emergency exit 24 is closed, the emergency exit 24 pushes down the door limit switch, and when the emergency exit 24 is opened, the door limit switch bounces.

Further, as shown in fig. 1, a pressing knob 25 is disposed above the frame opening 23, a pressing plate 26 is disposed at the top of the rotating cage 22, the pressing knob 25 is connected to the pressing plate 26, the pressing knob 25 drives the pressing plate 26 to move up and down by rotation, and the rotating cage 22 is used for covering and pressing the inner circumference turntable of the layered support 111 on the inner vehicle 11. Preventing the liquid preparation in the rotating disc from being poured out during the rotating process. Specifically, the pressing knob 25 is rotated by a wrench, and the pressing plate 26 is driven by the mechanical thread to move up and down. The degree of compression of the compression plate 26 against the epicyclic is sensed by the strength of the wrench rotation.

Further, as shown in fig. 1 and 3, a baffle 27 is disposed at the bottom of the frame opening 23, two ends of the baffle 27 are provided with limiting holes 271, and the limiting holes 271 are matched with one end of the outer guide rail 121 on the tank car 12, which is used for pushing the inner car 11 into the rotating cage 22. That is, the front end of the outer guide rail 121 can be inserted into the limiting hole 271 for fixing, so that the inner car 11 is prevented from falling off due to rolling of the tank car 12 in the process of pushing the inner car 11 into the rotating cage body 22.

Further, as shown in fig. 4, an inner guide rail 227 is disposed at the bottom inside the rotating cage 22, and the inner guide rail 227 is matched with the rail wheel at the bottom of the inner vehicle 11. Namely, the rail wheels can be arranged in the inner guide rail 227 to roll, so that the inner vehicle 11 can be conveniently pushed into the rotating cage 22.

Further, as shown in fig. 2, a proximity switch is provided on the frame 21. The proximity switch is a positioning switch.

Further, as shown in fig. 1 and 2, a support base plate 211 is disposed in the frame 21, and the rotating cage 22 is disposed on the support base plate 211.

Further, as shown in fig. 1, a control part 28 is provided at one side of the frame opening 23, and the control part 28 includes the following parts:

the power switch 281 is externally connected with a power supply and used for supplying power to equipment;

an alarm 282;

an emergency stop switch 283, wherein the emergency stop switch 283 is used for emergency closing of the hybrid operation of the rotating cage body 22;

a display screen 284, the display screen 284 being used to input hybrid operation information to the rotating cage 22;

a printer 285;

and the controller is respectively connected with the display screen 284, the alarm 282 and the printer 285, and is used for receiving the mixed operation information signal sent by the display screen 284, sending a mixed operation completion signal to the alarm 282 and sending a signal for printing the mixed operation information to the printer 285.

Still further, the controller is a conventionally used PLC controller. Those skilled in the art will appreciate that the calculation, comparison, judgment and instruction output processes of the controller can be implemented by using integrated circuit modules, programmable logic devices, other hardware or installing corresponding software modules in the prior art. For example, specifically, the controller is a PLC controller model S7-200CN manufactured by SIEMENS Siemens Inc. The control means have stored thereon a computer program which, when executed, enables a rotating hybrid operation of the rotating cage 22 in the mixing means 2.

In a preferred embodiment, as shown in fig. 1, 2 and 4, the rotating cage 22 includes a plurality of limiting rollers 221 sequentially arranged along the interior sampling direction, a rotating roller 222, a transmission supporting wheel 223, a gear motor 224 and a frequency converter 225 are arranged outside the rotating cage 22, the rotating roller 222 is located in the middle of the rotating cage 22, the rotating roller 222, the transmission supporting wheel 223 and the gear motor 224 are sequentially connected through gear coupling transmission, the frequency converter 225 is connected with the gear motor 224 for sending a rotating signal to the gear motor 224, and the gear motor 224 rotates after receiving the rotating signal sent by the frequency converter 225. The frequency converter 225 can regulate the rotational speed of the rotating cage 22. The frequency converter 225 is a frequency converter which is conventionally used, and specifically, the frequency converter 225 is an ATV310HU30N4A frequency converter manufactured by Schneider. The frequency converter 225 is connected to the controller, and the frequency converter 225 is configured to receive the rotation signal sent by the controller.

Further, as shown in fig. 1 and 2, a limiting block 2211 is disposed on the limiting roller 221. The limiting block 2211 is in contact with the proximity switch. In the rolling process of the limit roller 221, each time the limit block 2211 rotates to approach the proximity switch, the position to which the rotating cage 22 rotates can be determined. The stopper 2211 is located at an edge of the rotating roller 222.

Further, as shown in fig. 4, a base 226 is provided at a lower portion of the transmission support wheel 223.

Further, as shown in fig. 1, 2 and 4, the frequency converter 225 is disposed in the distribution box.

The invention further provides a use method of the equipment for uniformly mixing the liquid preparation, which comprises the following steps:

1) in a sample injection mechanism, the liquid preparation is put into the inner vehicle;

2) then, after the inner vehicle is pushed into the rotating cage body, the rotating cage body is started to rotate and mix;

3) taking out the inner vehicle from the rotating cage body after rotating and mixing, and opening the inner vehicle to take out the uniformly mixed liquid preparation.

Example 1

Inner car 11 is mounted on tanker 12 by rail wheels 113 engaging with lateral outer rails 121 on tanker 12. The interlocking switch 13 in the middle of the outer guide rails 121 on the two sides is toggled, the interlocking switch 13 is a clamping sheath type mechanical interlocking switch, a first clamping sheath piece of the interlocking switch 13, which is arranged on the inner vehicle 11, and a second clamping sheath piece of the interlocking switch 13, which is arranged on the tank wagon 12, are in limited clamping connection, so that the inner vehicle 11 cannot move back and forth on the tank wagon 12, and the inner vehicle 11 is prevented from sliding down from the tank wagon 12. Respectively placing the liquid preparation into a plurality of week rotary tables, wherein the liquid preparation is pulse-activating injection added with surfactant as solubilizer, the surfactant is polysorbate-80, and the placing amount is 170 ampoules per disc of 20 ml or 270 ampoules per disc of 10 ml. The net fence 112 at one end of the inner vehicle 11 is opened, a plurality of turnover discs are respectively placed in a plurality of layered supports 111 in the inner vehicle 11, soft pads are arranged between adjacent turnover discs in an auxiliary mode, therefore, the impact in the rotating process is weakened, the net fence 112 is closed, the mesh aperture of the net fence 112 is smaller than the opening of the turnover discs, and the turnover discs are prevented from leaking. The tanker 12 is pushed by the steering wheel at the bottom of the tanker 12 to the frame opening 23 of the mixing mechanism 2. The safety door 24 on the frame opening 23 is opened, the front end of the guide rail 121 of the tank car 12 is aligned and inserted into the limit hole 271 of the baffle 27 for fixing, so that the tank car 12 is prevented from rolling to cause the falling of the tank car 11 in the process that the tank car 11 is pushed into the rotating cage body 22. The handle on the interlocking switch 13 is manually pulled, so that the tank car 12 and the interlocking switch 13 on the inner car 11 are unlocked, the inner car 11 is pushed into the rotating cage body 22 through the frame opening 23, the rail wheels at the bottom of the inner car 11 are matched with the inner guide rail 227, and the inner car 11 is smoothly pushed into the rotating cage body 22. After the inner vehicle 11 is completely pushed into the rotating cage 22, the pressing plate 26 is lowered by rotating the pressing knob 25, and the pressing plate 26 covers and presses the inner circumference turntable of the layered bracket 111 on the inner vehicle 11, so that the liquid preparation in the inner circumference turntable is prevented from being poured out in the rotating process.

The emergency gate 24 is closed, the power switch 281 on the control unit 28 is opened, and the display screen 284 is turned on. In order to ensure the safety of the equipment in the using process, only under the condition that the safety door 24 is closed, the door limit switch is triggered, the safety door closing signal is sent through the door limit switch, and after the controller receives the safety door closing signal of the door limit switch, the mixing mechanism can operate. The control screen 28 is controlled by the controller, mixed operation information is input into the rotating cage body 22 through control screen parameter setting or mode selection on the operation interface of the display screen 284, the display screen 284 displays two programs of automatic and manual operation, the rotating cage body 22 can rotate at fixed time, orientation and fixed speed in the automatic program, and the rotating time and speed can be determined through the parameter input display screen 284; the manual procedure can be used to rotate and position the rotating cage 22 (to fix the position of the rotating cage 22 for easy access of the interior vehicle 11). During specific operation, mixed operation information is input to the rotating cage 22 through the display screen 284, after the controller receives a mixed operation information signal sent by the display screen 284, a rotating signal is sent to the frequency converter 225, and then the frequency converter 225 sends a rotating signal to the gear motor 224, after the gear motor 224 receives the rotating signal, the gear motor drives the transmission supporting wheel 223 to rotate through gear coupling transmission at a certain rotating speed, so as to drive the rotating roller 222 to rotate, so that the limiting roller 221 rotates, and finally, the rotating cage 22 performs self-rotation motion under the guidance and limiting of the limiting roller 221, so that liquid preparations in the upper peripheral turntable of the inner vehicle 11 are uniformly mixed.

In the process of mixing the liquid preparation, the rotating speed of the rotating cage body 22 is 9-11 circles/min, preferably 10 circles/min; the rotation speed of the limit roller 221 is 9-11 circles/min, preferably 10 circles/min. If the mixing mechanism 2 is in an emergency, the emergency stop switch 283 can be pressed to emergently close the mixing operation of the rotating cage 22. After the liquid preparation is mixed completely, namely after the rotating mixing time reaches the set time, the program automatically positions, the controller sends a rotation stopping signal to the frequency converter 225, the gear motor 224 receives the rotation stopping signal sent by the frequency converter 225 and then performs low-speed positioning operation, and when the limiting block 2211 is close to the proximity switch on the frame 21, the controller sends a rotation stopping signal. Through gear coupling transmission, drive transmission supporting wheel 223 stop rotating, and then drive and rotate gyro wheel 222 and stop rotating to make spacing gyro wheel 221 stop rotating, make finally on the rotatory cage 22 slowly rotate to the initial position under the guide of spacing gyro wheel 221 and spacing and stop, rotatory cage 22 location relies on the positioning switch to feed back the signal. After the positioning is completed, the controller sends a mixed operation completion signal to the alarm 282, and the alarm 282 gives an alarm sound to confirm that the mixed operation of the rotating cage 22 is completed. The printer 285 is started, and the printer 285 prints the mixing operation information of the rotating cage 22 in the rotating and blending process displayed on the display screen 284 through the controller.

When the emergency gate 24 is opened, the gate limit switch is triggered, and the controller sends an emergency gate opening signal to the display screen 284 according to the gate limit switch 251. Through the rotation of the pressing knob 25, the pressing plate 26 is lifted, the inner vehicle 11 is pulled out from the rotating cage 22, then the tank wagon 12 and the inner vehicle 11 are locked through the interlocking switch 13, the front section of the outer guide rail 121 of the tank wagon 12 is separated from the limiting hole 271 on the rotating cage 22, and the inner vehicle 11 is pulled out of the rotating cage 22 through the frame opening 23. The tank wagon 12 is pushed to a subsequent process place through a direction wheel at the bottom of the tank wagon 12, a net fence 112 at one end of the inner wagon 11 is opened, a plurality of turnover tables are taken out from a plurality of layered supports 111 in the inner wagon 11, the turnover tables are opened, and the uniformly mixed liquid preparation is taken out for subsequent processes. At the same time, the power switch 281 on the control panel 28 is closed.

The above steps are repeated again using the above apparatus.

Comparative example 1

The liquid preparation is mixed according to the conventional manual method, namely the liquid preparation is taken and put into a week rotary table, a cover with a soft cushion at the edge is taken to cover the week rotary table, the week rotary table is manually moved up to the position in front of the chest, and the liquid preparation is turned over for a plurality of times up, down, left and right. And opening the cover, and taking out the uniformly mixed liquid preparation for subsequent processes.

Example 2

Comparing the mixing method of example 1 with that of comparative document 1, the mixing method of the present invention using the apparatus can save labor; moreover, a plurality of circumference rotating discs such as 36 discs can be loaded on the inner vehicle at the same time, so that the production efficiency is obviously improved; and a plurality of week carousel carries out synchronous revolution, and the rocking disc is stable good, and the uniformity of mixing liquid is good. Therefore, the automatic rotation of the device is obviously superior to manual tray-rocking operation.

In conclusion, according to the equipment for uniformly mixing the liquid preparation and the application thereof provided by the invention, the automatic rotating mechanical equipment is adopted to replace manual tray shaking operation, so that the uniform mixing of products in multiple trays can be realized, and the equipment is convenient to operate, reliable in performance, safe and stable, and very worthy of popularization and application. Therefore, the invention effectively overcomes various defects in the prior art and has high industrial utilization value.

The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.

Claims (6)

1. The equipment for uniformly mixing the liquid preparations is characterized by comprising a sample injection mechanism (1) and a mixing mechanism (2), wherein the sample injection mechanism (1) comprises an inner vehicle (11) for placing the liquid preparations, the mixing mechanism (2) comprises a rotating cage body (22), and the rotating cage body (22) is matched with the inner vehicle (11) and is used for rotatably mixing the liquid preparations placed on the inner vehicle (11);

the sample feeding mechanism (1) further comprises a tank car (12), and the tank car (12) is positioned below the inner car (11) and used for carrying the inner car (11);

a plurality of layered supports (111) are arranged in the inner vehicle (11) from top to bottom, a plurality of turnover discs are placed in each layered support (111), and the turnover discs are used for placing liquid preparations;

the mixing mechanism (2) further comprises a frame (21), the frame (21) is hollow, a frame opening (23) is formed in the side wall of one side of the frame (21), a rotating cage body (22) is arranged in the frame (21), one end of the rotating cage body (22) is communicated with the frame opening (23), and the rotating cage body (22) is matched with the inner vehicle (11) through the frame opening (23);

the mixing mechanism includes any one or more of the following conditions:

B1) the frame opening (23) is provided with an openable safety door (24);

B2) a pressing knob (25) is arranged above the frame opening (23), a pressing plate (26) is arranged at the top of the rotating cage body (22), the pressing knob (25) is connected with the pressing plate (26), the pressing knob (25) is driven by rotation to lift the pressing plate (26) up and down, and an inner peripheral turntable of a layered support (111) on the inner vehicle (11) entering the rotating cage body (22) is covered and pressed;

B3) a baffle (27) is arranged at the bottom of the frame opening (23), two ends of the baffle (27) are provided with limiting holes (271), and the limiting holes (271) are matched with one end, used for pushing the inner vehicle (11) into the rotary cage body (22), of the upper outer guide rail (121) of the tank car (12);

B4) an inner guide rail (227) is arranged at the bottom inside the rotary cage body (22), and the inner guide rail (227) is matched with a rail wheel at the bottom of the inner vehicle (11);

B5) a supporting base plate (211) is arranged in the frame (21), and a rotary cage body (22) is placed on the supporting base plate (211).

2. The equipment for uniformly mixing the liquid preparation according to claim 1, wherein outer guide rails (121) are arranged on two sides above a loading platform of the tank car (12), rail wheels are arranged on two sides of the bottom of the inner car (11), and the outer guide rails (121) are matched with the rail wheels and used for placing the inner car (11).

3. The device for the homogeneous mixing of liquid preparations according to claim 1, wherein a control member (28) is provided at one side of the frame opening (23), the control member (28) comprising:

the power switch (281), the said power switch (281) connects the power, is used for delivering the power to the apparatus;

an alarm (282);

an emergency stop switch (283), the emergency stop switch (283) being used for emergency shutdown of hybrid operation of the rotating cage (22);

a display screen (284), the display screen (284) for inputting hybrid operation information to the rotating cage (22);

a printer (285);

the controller is respectively connected with the display screen (284), the alarm (282) and the printer (285), is used for receiving the mixed operation information signal sent by the display screen (284), sends a mixed operation completion signal to the alarm (282) and sends a signal for printing the mixed operation information to the printer (285).

4. The device for uniformly mixing the liquid preparations according to claim 1, wherein the rotating cage body (22) comprises a plurality of limiting rollers (221) which are sequentially arranged along the sample introduction direction of the inner vehicle (11), a rotating roller (222), a transmission supporting wheel (223), a gear motor (224) and a frequency converter (225) are arranged outside the rotating cage body (22), the rotating roller (222) is positioned in the middle of the rotating cage body (22), the rotating roller (222), the transmission supporting wheel (223) and the gear motor (224) are sequentially connected through gear coupling transmission, and the frequency converter (225) is connected with the gear motor (224) and used for sending a rotating signal to the gear motor (224).

5. Use of an apparatus for mixing liquid formulations according to any of claims 1-4 in the mixing of liquid formulations.

6. The use method of the device for uniformly mixing the liquid preparation according to any one of claims 1 to 4, comprising the following steps:

1) in a sample injection mechanism, the liquid preparation is put into the inner vehicle;

2) then, after the inner vehicle is pushed into the rotating cage body, the rotating cage body is started to rotate and mix;

3) taking out the inner vehicle from the rotating cage body after rotating and mixing, opening the inner vehicle and taking out the uniformly mixed liquid preparation;

in the step 1), the inner vehicle is placed on a tank car.

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