CN109923125B - 免疫原性组合物 - Google Patents

免疫原性组合物 Download PDF

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Publication number
CN109923125B
CN109923125B CN201780051719.XA CN201780051719A CN109923125B CN 109923125 B CN109923125 B CN 109923125B CN 201780051719 A CN201780051719 A CN 201780051719A CN 109923125 B CN109923125 B CN 109923125B
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China
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gly
asn
leu
ile
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CN201780051719.XA
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English (en)
Chinese (zh)
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CN109923125A (zh
Inventor
C·汤普森
S·古普塔
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Oxford University Innovation Ltd
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Oxford University Innovation Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/275—Poxviridae, e.g. avipoxvirus
    • A61K39/285—Vaccinia virus or variola virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201780051719.XA 2016-08-25 2017-08-25 免疫原性组合物 Active CN109923125B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1614485.9A GB201614485D0 (en) 2016-08-25 2016-08-25 Immunogenic composition
GB1614485.9 2016-08-25
PCT/GB2017/052510 WO2018037246A1 (en) 2016-08-25 2017-08-25 Immunogenic composition

Publications (2)

Publication Number Publication Date
CN109923125A CN109923125A (zh) 2019-06-21
CN109923125B true CN109923125B (zh) 2024-05-31

Family

ID=57119951

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780051719.XA Active CN109923125B (zh) 2016-08-25 2017-08-25 免疫原性组合物

Country Status (8)

Country Link
US (2) US11123422B2 (https=)
EP (1) EP3504235A1 (https=)
JP (2) JP7203015B2 (https=)
CN (1) CN109923125B (https=)
AU (3) AU2017315238A1 (https=)
CA (1) CA3034328A1 (https=)
GB (1) GB201614485D0 (https=)
WO (1) WO2018037246A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201614485D0 (en) * 2016-08-25 2016-10-12 Univ Oxford Innovation Ltd Immunogenic composition
WO2020061443A2 (en) * 2018-09-21 2020-03-26 Board Of Regents Of The University Of Nebraska Methods of making and using universal centralized influenza vaccine genes
GB2578163A (en) * 2018-10-19 2020-04-22 Univ Pretoria Plant produced avian influenza antigens and their uses in diagnostic assays and devices
GB202204478D0 (en) * 2022-03-29 2022-05-11 Univ Oxford Innovation Ltd Immunogenic compositions

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1200147A (zh) * 1995-09-01 1998-11-25 科里克萨有限公司 用于免疫治疗和诊断结核病的化合物和方法
WO2003075952A1 (en) * 2002-03-05 2003-09-18 Board Of Regents, The University Of Texas System Methods of enhancing immune induction involving mda-7
CN102939102A (zh) * 2010-04-09 2013-02-20 乌得勒支大学控股有限责任公司 重组多聚流感蛋白
WO2013177444A2 (en) * 2012-05-23 2013-11-28 The Board Of Trustees Of The Leland Stanford Junior University Influenza vaccine constructs
CN103435697A (zh) * 2006-05-15 2013-12-11 航道生物技术有限责任公司 流感病毒的中和抗体
CN104278014A (zh) * 2006-08-09 2015-01-14 米迪缪尼有限公司 流感血凝素和神经氨酸酶变体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235877A (en) 1979-06-27 1980-11-25 Merck & Co., Inc. Liposome particle containing viral or bacterial antigenic subunit
CA2035576A1 (en) 1990-02-07 1991-08-08 Alexander R. Neurath Conformational epitopes of human immunodeficiency virus envelope glycoprotein gp120 hiv-1
AU2006236910B2 (en) * 2005-04-11 2012-06-07 Purdue Research Foundation Vaccine against pandemic strains of influenza viruses
NZ590351A (en) 2008-07-18 2012-11-30 Medicago Inc HA1 domain totally or partially free of N-linked glycosylation operatively linked to a regulatory region
CA2807664A1 (en) * 2010-08-12 2012-02-16 Theraclone Sciences, Inc. Anti-hemagglutinin antibody compositions and methods of use thereof
US8883171B2 (en) 2010-09-14 2014-11-11 University of Pittsburgh—of the Commonwealth System of Higher Education Computationally optimized broadly reactive antigens for influenza
WO2012089231A1 (en) 2010-12-30 2012-07-05 Okairòs Ag Paramyxovirus vaccines
US8932598B2 (en) * 2012-08-28 2015-01-13 Vaxinnate Corporation Fusion proteins and methods of use
ES2803508T3 (es) 2013-03-28 2021-01-27 Medicago Inc Producción de partículas similares al virus de la gripe en plantas
GB201614485D0 (en) * 2016-08-25 2016-10-12 Univ Oxford Innovation Ltd Immunogenic composition

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1200147A (zh) * 1995-09-01 1998-11-25 科里克萨有限公司 用于免疫治疗和诊断结核病的化合物和方法
WO2003075952A1 (en) * 2002-03-05 2003-09-18 Board Of Regents, The University Of Texas System Methods of enhancing immune induction involving mda-7
CN103435697A (zh) * 2006-05-15 2013-12-11 航道生物技术有限责任公司 流感病毒的中和抗体
CN104278014A (zh) * 2006-08-09 2015-01-14 米迪缪尼有限公司 流感血凝素和神经氨酸酶变体
CN102939102A (zh) * 2010-04-09 2013-02-20 乌得勒支大学控股有限责任公司 重组多聚流感蛋白
WO2013177444A2 (en) * 2012-05-23 2013-11-28 The Board Of Trustees Of The Leland Stanford Junior University Influenza vaccine constructs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A virus-like particle that elicits cross-reactive antibodies to the conserved stem of influenza virus hemagglutinin;Anette Schneemann等;《J Virol》;20121130(第21期);全文 *

Also Published As

Publication number Publication date
WO2018037246A4 (en) 2018-04-19
US20190201521A1 (en) 2019-07-04
AU2026200025A1 (en) 2026-01-22
JP2019534242A (ja) 2019-11-28
JP2023052092A (ja) 2023-04-11
US20220054625A1 (en) 2022-02-24
GB201614485D0 (en) 2016-10-12
AU2017315238A1 (en) 2019-02-21
CN109923125A (zh) 2019-06-21
WO2018037246A1 (en) 2018-03-01
US11123422B2 (en) 2021-09-21
EP3504235A1 (en) 2019-07-03
AU2024227680A1 (en) 2024-11-21
JP7762643B2 (ja) 2025-10-30
US12390518B2 (en) 2025-08-19
CA3034328A1 (en) 2018-03-01
JP7203015B2 (ja) 2023-01-12

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