CN109922818B - Cxcr4拮抗剂及使用方法 - Google Patents

Cxcr4拮抗剂及使用方法 Download PDF

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Publication number
CN109922818B
CN109922818B CN201780054250.5A CN201780054250A CN109922818B CN 109922818 B CN109922818 B CN 109922818B CN 201780054250 A CN201780054250 A CN 201780054250A CN 109922818 B CN109922818 B CN 109922818B
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CN
China
Prior art keywords
lys
ipr
gly
misc
peptide
Prior art date
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Expired - Fee Related
Application number
CN201780054250.5A
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English (en)
Chinese (zh)
Other versions
CN109922818A (zh
Inventor
J·张
L·Z·严
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Mainline Biosciences Inc
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Mainline Biosciences Inc
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Publication of CN109922818A publication Critical patent/CN109922818A/zh
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201780054250.5A 2016-09-06 2017-09-05 Cxcr4拮抗剂及使用方法 Expired - Fee Related CN109922818B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662384132P 2016-09-06 2016-09-06
US62/384,132 2016-09-06
US201762505064P 2017-05-11 2017-05-11
US62/505,064 2017-05-11
PCT/US2017/050106 WO2018048806A1 (en) 2016-09-06 2017-09-05 Cxcr4 antagonists and methods of use

Publications (2)

Publication Number Publication Date
CN109922818A CN109922818A (zh) 2019-06-21
CN109922818B true CN109922818B (zh) 2024-02-20

Family

ID=61281979

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780054250.5A Expired - Fee Related CN109922818B (zh) 2016-09-06 2017-09-05 Cxcr4拮抗剂及使用方法

Country Status (6)

Country Link
US (2) US10351601B2 (enExample)
EP (1) EP3509612A4 (enExample)
JP (1) JP7100639B2 (enExample)
CN (1) CN109922818B (enExample)
CA (1) CA3032885C (enExample)
WO (1) WO2018048806A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11123437B2 (en) 2017-09-05 2021-09-21 Mainline Biosciences, Inc. Selective CXCR4 binding peptide conjugate and methods for making and using the same
US10639379B2 (en) * 2017-09-05 2020-05-05 Mainline Biosciences Llc High affinity CXCR4 selective binding conjugate and method for using the same
WO2019126796A1 (en) * 2017-12-21 2019-06-27 Mainline Biosciences Llc Composition comprising a therapeutic agent and a cxcr4 selective antagonist and methods for using the same
EP4097120A4 (en) * 2020-01-26 2024-05-01 Mainline Biosciences (Shanghai) Co., Ltd. ISOTOPE-LABELED CXCR4 SELECTIVELY BINDING PEPTIDE CONJUGATE AND METHODS OF MAKING AND USE THEREOF
US12486304B2 (en) * 2022-02-11 2025-12-02 C-Biomex Co., Ltd. Peptide ligand targeting carbonic anhydrase IX, peptide construct comprising same, and uses thereof
GB2628421A (en) * 2023-03-24 2024-09-25 Syntherix Ltd Peptides and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001085196A2 (en) * 2000-05-09 2001-11-15 The University Of British Columbia Cxcr4 antagonist treatment of hematopoietic cells
CN1968964A (zh) * 2004-06-18 2007-05-23 Ipf医药有限公司 寡聚肽及其治疗hiv感染的用途
CN101678213A (zh) * 2007-05-30 2010-03-24 伊莱利利公司 环肽cxcr4拮抗剂
CN102869675A (zh) * 2010-01-26 2013-01-09 国家研究委员会 结合cxcr4受体的环状肽和相对医疗和诊断用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058243A1 (ja) * 2002-12-26 2004-07-15 Ajinomoto Co., Inc. 肝癌発生・進展抑制剤
CA2643744A1 (en) * 2006-02-27 2007-08-30 Technische Universitaet Muenchen Cancer imaging and treatment
SG11201400354PA (en) * 2011-10-07 2014-09-26 Polyphor Ag Template -fixed peptidomimetics as inhibitors of fpr1
CN102626522B (zh) * 2012-04-12 2014-09-10 韩彦江 基于趋化因子受体cxcr4多肽类拮抗剂的多肽放射性诊断与治疗药物
CA2875733C (en) * 2012-06-06 2019-09-10 Polyphor Ag Beta-hairpin peptidomimetics
US9790286B2 (en) * 2013-01-02 2017-10-17 Lucia Irene Gonzalez Stereoisomer peptides, their polymer conjugates, their encapsulation into nanoparticles, and uses thereof for the treatment of diseases caused by abnormal angiogenesis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001085196A2 (en) * 2000-05-09 2001-11-15 The University Of British Columbia Cxcr4 antagonist treatment of hematopoietic cells
CN1968964A (zh) * 2004-06-18 2007-05-23 Ipf医药有限公司 寡聚肽及其治疗hiv感染的用途
CN101678213A (zh) * 2007-05-30 2010-03-24 伊莱利利公司 环肽cxcr4拮抗剂
CN102869675A (zh) * 2010-01-26 2013-01-09 国家研究委员会 结合cxcr4受体的环状肽和相对医疗和诊断用途

Also Published As

Publication number Publication date
US10870681B2 (en) 2020-12-22
EP3509612A4 (en) 2021-07-21
CA3032885A1 (en) 2018-03-15
US20190309023A1 (en) 2019-10-10
CN109922818A (zh) 2019-06-21
EP3509612A1 (en) 2019-07-17
CA3032885C (en) 2023-06-20
WO2018048806A1 (en) 2018-03-15
US10351601B2 (en) 2019-07-16
JP7100639B2 (ja) 2022-07-13
US20180066021A1 (en) 2018-03-08
JP2019534893A (ja) 2019-12-05

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