CN109908408A - A kind of preparation method and application of the pure Zinc material of human body degradable biological - Google Patents
A kind of preparation method and application of the pure Zinc material of human body degradable biological Download PDFInfo
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Abstract
The present invention provides a kind of preparation method of pure Zinc material of human body degradable biological, the following steps are included: (1) is forged: keeping the temperature 2.5-4h after zinc ingot metal is heated to 150-180 DEG C, then it is forged using the pneumatic hammer of 250Kg in the axial direction of zinc ingot metal, 85-90% is reduced to the length of zinc ingot metal in the axial direction, obtains bar；(2) Equal-channel Angular Pressing: being again heated to 130-140 DEG C for bar, then squeezes bar 3-5 times by Equal-channel Angular Pressing.The pure Zinc material of human body degradable biological can be used for preparing medical degradable instrument.Preparation method provided by the invention can make the tensile strength of pure Zinc material improve 76-83% or so, make it possible to and apply in the preparation of medical degradable instrument.Since the cost of zinc is low, after the tensile strength of zinc is improved, compared with degradable zinc alloy material, the material cost of medical degradable instrument is reduced.
Description
Technical field
The invention belongs to biodegradable metals technical fields, and in particular to a kind of pure Zinc material of human body degradable biological
Preparation method and application.
Background technique
Zinc ion is the essential trace elements of the human body, participates in many metabolic activities of human body.Wherein, the one of zinc ion
A critical function is exactly that it can promote bone tissue to generate.Research finds that aminoacyl tRNA in osteoblast can be activated due to zinc ion
Synzyme, and the differentiation and growth of osteoclast can be effectively suppressed, this illustrates that zinc ion has direct rush osteogenesis function.
Pure zinc is a kind of degradable material under human body environment, but pure zinc only has 120Mpa tensile strength, plasticity and anti-
Tensile strength is poor, can not apply in medical degradable material.It is all at present by being added to it other metallic element alloys
Change to improve its mechanical strength, kirsite is prepared by the way that other metallic elements are added, although its intensity can be improved, but
It is at high cost.This is not very high human body implantable apparatus for intensity requirement, is that cost is too high nothing but.And the price pole of pure zinc
It is low.But in the prior art due to the intensity difference of the pure zinc of metal, the pure zinc of metal is not applied to the feelings of human body implantable apparatus
Condition.
Equal-channel Angular Pressing is to generate big cut by repeatedly extruding under the premise of not changing the cross-sectional area of material
Shear deformation repeatedly extrudes the dependent variable accumulation superposition that can make each deformation and obtains sizable overall strain amount.It is squeezed in channel
During out, high deformation energy storage promotes sub boundary to convert to wide-angle Jing Du circle, the material of fine-grain is generated, to improve
The mechanical performances such as the tensile strength of sample.Forging is that blank applies pressure with forging hammer hammering or press machine after heating, real
It is now plastically deformed to obtain the plastic molding method of certain shapes, size and performance forging.
But Equal Channel Angular Pressing can the mechanical performances such as larger raising intensity to metals such as steel, titanium, Nitinols
There is preferable effect.But the effect is unsatisfactory for the metal material all low to this tensile strength of pure zinc and plasticity, through squeezing
The requirement of the not high bone implanting appliance of Maxillary region and intensity requirement is still much not achieved in tensile strength afterwards.
In the prior art, the tensile strength of high molecular degradable material (polylactic acid) only has 100MPa or so, can be used for
Degradable miniature bone plate, bone nail, bone set and bone folder are prepared, but due to its intensity difference, there is broken apparatus accident hair when in operation
It is raw.
Summary of the invention
In view of the drawbacks of the prior art, the present invention provides a kind of preparation method of pure Zinc material of human body degradable biological, institute
The tensile strength of high purity zinc can be proposed by stating preparation method, can prepare the miniature bone plate of biodegradable, bone nail, bone set or bone
Folder.
A kind of preparation method of the pure Zinc material of human body degradable biological, comprising the following steps:
(1) it forges: keeping the temperature 2.5-4h after zinc ingot metal is heated to 150-180 DEG C, then use the pneumatic hammer of 250Kg in the axis of zinc ingot metal
It is forged to direction, until the length of zinc ingot metal in the axial direction reduces 85-90%, obtains bar；
(2) Equal-channel Angular Pressing: being again heated to 130-140 DEG C for bar, then squeezes bar by Equal-channel Angular Pressing
Pressure 3-5 times.
Preferably, the hammering frequency of the forging is that pneumatic hammer hammers 30 times per minute.
Preferably, the Equal-channel Angular Pressing specifically comprises the processes of: use squeeze pressure for 400 tons of vertical extruder
Extruded bars are removed with the extruding rate of 4mm/s, it includes first by bar by again rotating bar counterclockwise after squeezing that 1 time, which squeezes,
90 ° are squeezed.
Preferably, the mass percentage of zinc is 99-99.9% in the zinc ingot metal, remaining is impurity.
Preferably, the mass percentage of zinc is 99-99.5% in the zinc ingot metal, remaining is impurity.
The pure Zinc material of human body degradable biological is preparing the application in medical degradable instrument.
Preferably, the medical degradable instrument is that Esophageal Stent, urethra rack, intestinal stent, trachea bracket or bone are planted
Enter instrument.
Preferably, the bone implanting appliance is miniature bone plate, bone nail, bone set or bone folder.
Of the present invention be forged to hammers zinc ingot metal using pneumatic hammer, is referred to as hammering.
Advantages of the present invention:
(1) preparation method provided by the invention can make the tensile strength of pure Zinc material improve 76-83% or so, make it possible to and answer
In the preparation of medical degradable instrument.
(2) since the cost of zinc is low, after method provided by the invention improves the tensile strength of zinc, with degradable kirsite
Material is compared, and the material cost of medical degradable instrument is reduced.
Detailed description of the invention
The scanning electron microscope (SEM) photograph of the pure Zinc material of human body degradable biological prepared by Fig. 1 embodiment 1.
Specific embodiment
The zinc ingot metal used in the embodiment of the present invention for diameter is 50mm, the zinc ingot metal that length is 100mm.Zinc ingot metal of the present invention
Length, refer to the length of zinc ingot metal in the axial direction.
Embodiment 1
A kind of preparation method of the pure Zinc material of human body degradable biological, comprising the following steps:
(1) it forges: the zinc ingot metal that diameter is 50mm, length 100mm, Zn content are 99.8% being pulled down into crust, is then heated to
3h is kept the temperature after 180 DEG C, is then forged using the pneumatic hammer of 250Kg in the axial direction of zinc ingot metal, the hammering frequency of forging is
Pneumatic hammer hammers 30 times per minute, and forging to the length of zinc ingot metal is 15mm, and the length of axial direction reduces 85%；
(2) Equal-channel Angular Pressing: being again heated to 140 DEG C for bar, then uses squeeze pressure for 400 tons of vertical extruder
Extruded bars are removed with the extruding rate of 4mm/s, it includes first by bar by again rotating bar counterclockwise after squeezing that 1 time, which squeezes,
90 ° are squeezed, and are iterated through Equal-channel Angular Pressing and are squeezed 3 times.
Embodiment 2
A kind of preparation method of the pure Zinc material of human body degradable biological, comprising the following steps:
(1) it forges: the zinc ingot metal that diameter is 50mm, length 100mm, Zn content are 99.3% being pulled down into crust, is then heated to
2.5h is kept the temperature after 170 DEG C, is then forged using the pneumatic hammer of 250Kg in the axial direction of zinc ingot metal, the hammering frequency of forging
It is hammered per minute for pneumatic hammer 30 times, the length of forging to zinc ingot metal is 10mm, and the length of axial direction reduces 90%；
(2) Equal-channel Angular Pressing: being again heated to 140 DEG C for bar, then uses squeeze pressure for 400 tons of vertical extruder
Extruded bars are removed with the extruding rate of 4mm/s, it includes first by bar by again rotating bar counterclockwise after squeezing that 1 time, which squeezes,
90 ° are squeezed, and are iterated through Equal-channel Angular Pressing and are squeezed 4 times.
Embodiment 3
A kind of preparation method of the pure Zinc material of human body degradable biological, comprising the following steps:
(1) it forges: the zinc ingot metal that diameter is 50mm, length 100mm, Zn content are 99.9% being pulled down into crust, is then heated to
2.5h is kept the temperature after 170 DEG C, is then forged using the pneumatic hammer of 250Kg in the axial direction of zinc ingot metal, the hammering frequency of forging
It is hammered per minute for pneumatic hammer 30 times, the length of forging to zinc ingot metal is 12mm, and the length of axial direction reduces 88%；
(2) Equal-channel Angular Pressing: being again heated to 140 DEG C for bar, then uses squeeze pressure for 400 tons of vertical extruder
Extruded bars are removed with the extruding rate of 4mm/s, it includes first by bar by again rotating bar counterclockwise after squeezing that 1 time, which squeezes,
90 ° are squeezed, and are iterated through Equal-channel Angular Pressing and are squeezed 4 times.
Embodiment 4
A kind of preparation method of the pure Zinc material of human body degradable biological, comprising the following steps:
(1) it forges: the zinc ingot metal that diameter is 50mm, length 100mm, Zn content are 99.5% being pulled down into crust, is then heated to
4h is kept the temperature after 150 DEG C, is then forged using the pneumatic hammer of 250Kg in the axial direction of zinc ingot metal, the hammering frequency of forging is
Pneumatic hammer hammers 30 times per minute, and forging to the length of zinc ingot metal is 13mm, and the length of axial direction reduces 87%；
(2) Equal-channel Angular Pressing: being again heated to 130 DEG C for bar, then uses squeeze pressure for 400 tons of vertical extruder
Extruded bars are removed with the extruding rate of 4mm/s, it includes first by bar by again rotating bar counterclockwise after squeezing that 1 time, which squeezes,
90 ° are squeezed, and are iterated through Equal-channel Angular Pressing and are squeezed 5 times.
Embodiment 5
A kind of preparation method of the pure Zinc material of human body degradable biological, comprising the following steps:
(1) it forges: the zinc ingot metal that diameter is 50mm, length 100mm, Zn content are 99.0% being pulled down into crust, is then heated to 16
3.5h is kept the temperature after DEG C, is then forged using the pneumatic hammer of 250Kg in the axial direction of zinc ingot metal, and the hammering frequency of forging is sky
Pneumatic hammer hammers 30 times per minute, and forging to the length of zinc ingot metal is 14mm, and the length of axial direction reduces 86%；
(2) Equal-channel Angular Pressing: being again heated to 135 DEG C for bar, then uses squeeze pressure for 400 tons of vertical extruder
Extruded bars are removed with the extruding rate of 4mm/s, it includes first by bar by again rotating bar counterclockwise after squeezing that 1 time, which squeezes,
90 ° are squeezed, and are iterated through Equal-channel Angular Pressing and are squeezed 5 times.
Blank example
The zinc ingot metal of any processing is not done as blank example using each embodiment.
Comparative example
Two comparative examples are arranged in each embodiment, and a comparative example is the step of zinc ingot metal only passes through forging, i.e., only carries out the embodiment
(1)；Another comparative example is the step of zinc ingot metal only passes through Equal-channel Angular Pressing, i.e., only carries out the embodiment (2), such as:
Two comparative examples, respectively comparative example 1.1 and comparative example 1.2 are arranged in embodiment 1:
Comparative example 1.1
The zinc ingot metal that diameter is 50mm, length 100mm, Zn content are 99.8% is pulled down into crust, is protected after being then heated to 180 DEG C
Then warm 3h is forged using the pneumatic hammer of 250Kg in the axial direction of zinc ingot metal, the hammering frequency of forging is every point of pneumatic hammer
Striker is hit 30 times, and forging to the length of zinc ingot metal is 12mm, and the length of axial direction reduces 76%.
Comparative example 1.2
Zinc ingot metal is heated to 140 DEG C, then using squeeze pressure is that 400 tons of vertical extruder is gone with the extruding rate of 4mm/s
It squeezes, squeezing for 1 time includes iterating through etc. logical first by zinc ingot metal by being rotated by 90 ° squeeze counterclockwise by zinc ingot metal again after squeezing
Road corner extrusion squeezes 3 times.
The material that one, obtains each embodiment and comparative example measures its tensile strength, the results are shown in Table 1.
1 tensile strength result of table
Two, grain sizes
The pure Zinc material of human body degradable biological that embodiment 1 is prepared, does scanning electron microscope, as a result such as Fig. 1, as shown in Figure 1,
Its grain size is at 2-5 μm.
Four, material provided by the invention, final strength in 210-220MPa or so, be used to prepare miniature bone plate, bone nail,
Bone set and bone folder, intensity can meet the requirements, crack conditions do not had in art, it is degradable can to prepare Medical orthopedic
Instrument.
Claims (8)
1. a kind of preparation method of the pure Zinc material of human body degradable biological, it is characterised in that: the following steps are included:
(1) it forges: keeping the temperature 2.5-4h after zinc ingot metal is heated to 150-180 DEG C, then use the pneumatic hammer of 250Kg in the axis of zinc ingot metal
It is forged to direction, until the length of zinc ingot metal in the axial direction reduces 85-90%, obtains bar；
(2) Equal-channel Angular Pressing: being again heated to 130-140 DEG C for bar, then squeezes bar by Equal-channel Angular Pressing
Pressure 3-5 times.
2. the preparation method of the pure Zinc material of human body degradable biological according to claim 1, it is characterised in that: the forging
Hammering frequency is that pneumatic hammer hammers 30 times per minute.
3. the preparation method of the pure Zinc material of human body degradable biological according to claim 1, it is characterised in that: the equal channels
Corner extrusion specifically comprises the processes of: using squeeze pressure is that 400 tons of vertical extruder goes extruded rod with the extruding rate of 4mm/s
Material, it includes first squeezing bar by being again rotated by 90 ° bar counterclockwise after squeezing that 1 time, which squeezes,.
4. the preparation method of the pure Zinc material of human body degradable biological according to claim 1, it is characterised in that: in the zinc ingot metal
The mass percentage of zinc is 99-99.9%, remaining is impurity.
5. the preparation method of the pure Zinc material of human body degradable biological according to claim 1, it is characterised in that: in the zinc ingot metal
The mass percentage of zinc is 99-99.5%, remaining is impurity.
6. a kind of pure Zinc material of human body degradable biological is preparing the application in medical degradable instrument, it is characterised in that: described
The pure Zinc material of human body degradable biological is prepared by any one of the claim 1-5 preparation method.
7. applying according to claim 6, it is characterised in that: the medical degradable instrument be Esophageal Stent, urethra rack,
Intestinal stent, trachea bracket or bone implanting appliance.
8. applying according to claim 7, it is characterised in that: the bone implanting appliance be miniature bone plate, bone nail, bone set or
Bone folder.
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Cited By (1)
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| CN110512117A (en) * | 2019-09-27 | 2019-11-29 | 石家庄新日锌业有限公司 | Medical zinc alloy material and preparation method thereof |
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