CN109906090A - 用于T1-MRI的新型脂质体钆(Gd)造影剂“NMRX” - Google Patents
用于T1-MRI的新型脂质体钆(Gd)造影剂“NMRX” Download PDFInfo
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- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (30)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201662395836P | 2016-09-16 | 2016-09-16 | |
US62/395,836 | 2016-09-16 | ||
PCT/IB2017/055611 WO2018051289A2 (en) | 2016-09-16 | 2017-09-15 | Novel liposomal gadolinium (gd) contrast agent "nmrx" for t1-mri |
Publications (1)
Publication Number | Publication Date |
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CN109906090A true CN109906090A (zh) | 2019-06-18 |
Family
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CN201780068432.8A Pending CN109906090A (zh) | 2016-09-16 | 2017-09-15 | 用于T1-MRI的新型脂质体钆(Gd)造影剂“NMRX” |
Country Status (4)
Country | Link |
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US (1) | US11052162B2 (zh) |
EP (1) | EP3512570A4 (zh) |
CN (1) | CN109906090A (zh) |
WO (1) | WO2018051289A2 (zh) |
Families Citing this family (1)
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WO2021155128A1 (en) * | 2020-01-29 | 2021-08-05 | Texas Children's Hospital | Targeted contrast agents for mri of amyloid deposition |
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US20160101197A1 (en) * | 2014-10-08 | 2016-04-14 | Texas Children's Hospital | MRI Imaging of Amyloid Plaque Using Liposomes |
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US7375202B2 (en) | 2003-03-24 | 2008-05-20 | The University Of Hong Kong | Human virus causing severe acute respiratory syndrome (SARS) and uses thereof |
RU2011137388A (ru) | 2009-02-11 | 2013-03-20 | Конинклейке Филипс Электроникс, Н.В. | Магнитно-резонансная визуализация кальциноза плаценты |
-
2017
- 2017-09-15 WO PCT/IB2017/055611 patent/WO2018051289A2/en unknown
- 2017-09-15 EP EP17850396.7A patent/EP3512570A4/en active Pending
- 2017-09-15 US US16/333,832 patent/US11052162B2/en active Active
- 2017-09-15 CN CN201780068432.8A patent/CN109906090A/zh active Pending
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US20070189974A1 (en) * | 2005-12-09 | 2007-08-16 | Fujifilm Corporation | Glycerophosphoric acid ester derivative having polyfunctional metal chelate structure |
US20080267882A1 (en) * | 2007-04-27 | 2008-10-30 | Stanford University | Imaging compounds, methods of making imaging compounds, methods of imaging, therapeutic compounds, methods of making therapeutic compounds, and methods of therapy |
CN102711840A (zh) * | 2009-11-20 | 2012-10-03 | 医药研究委员会 | 用于肿瘤磁共振成像的脂质体纳米颗粒 |
US20120107232A1 (en) * | 2010-10-29 | 2012-05-03 | Institute Of Nuclear Energy Research Atomic Energy Council, Executive Yuan | Kit for preparing a radiolabeled liposome and a method using the same |
US20130219636A1 (en) * | 2012-02-24 | 2013-08-29 | Nike, Inc. | Methods Of Manufacturing Articles Of Footwear With Tensile Strand Elements |
CN103721271A (zh) * | 2013-12-17 | 2014-04-16 | 福州市传染病医院 | 用于肝癌多模态影像和光热治疗的多功能纳米探针及应用 |
US20160101197A1 (en) * | 2014-10-08 | 2016-04-14 | Texas Children's Hospital | MRI Imaging of Amyloid Plaque Using Liposomes |
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CHOONG MO KANG ET AL: ""64Cu-Labeled tetraiodothyroacetic acid-conjugated liposomes for PET imaging of tumor angiogenesis"", 《NUCLEAR MEDICINE AND BIOLOGY》 * |
KETAN B. GHAGHADA ET AL: ""New Dual Mode Gadolinium Nanoparticle Contrast Agent for Magnetic Resonance Imaging"", 《PLOS ONE》 * |
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YONGYI ZENG ET AL: ""Lipid-AuNPs@PDA Nanohybrid for MRI/CT Imaging and Photothermal Therapy of Hepatocellular Carcinoma"", 《ACS APPL. MATER. INTERFACES》 * |
Also Published As
Publication number | Publication date |
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WO2018051289A3 (en) | 2018-04-26 |
US20190255196A1 (en) | 2019-08-22 |
US11052162B2 (en) | 2021-07-06 |
WO2018051289A2 (en) | 2018-03-22 |
EP3512570A2 (en) | 2019-07-24 |
EP3512570A4 (en) | 2020-06-03 |
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