CN109893785B - Focused ultrasound scientific research platform - Google Patents
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- CN109893785B CN109893785B CN201910208512.XA CN201910208512A CN109893785B CN 109893785 B CN109893785 B CN 109893785B CN 201910208512 A CN201910208512 A CN 201910208512A CN 109893785 B CN109893785 B CN 109893785B
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Abstract
The invention discloses a focused ultrasound scientific research platform, which relates to the technical field of high-strength focused ultrasound, and comprises the following components: the ultrasonic testing device comprises focusing ultrasonic equipment, an experimental operation table and a display device, wherein the focusing ultrasonic equipment is used for generating high-intensity focusing ultrasonic waves, the experimental operation table is used for fixing a test object, the display device captures image information in the experimental process and projects and displays the image information, and the ultrasonic scientific research platform which is low in cost, complete in function and suitable for teaching is provided through organically combining the focusing ultrasonic equipment, the experimental operation table and the display device.
Description
Technical Field
The invention relates to the technical field of high-strength focused ultrasound, in particular to a focused ultrasound scientific research platform.
Background
HIFU, high intensity focused ultrasound (HIFU, high Intensity Focused Ultrasound) refers to the use of ultrasound to focus low energy ultrasound in vitro at a target region in vivo, to generate biological effects such as transient high temperature, cavitation, mechanical action, etc. in a tumor, and to kill tumor cells in the target region.
In order to enable the HIFU technology to act on the tumor treatment mechanism, many basic experimental researches and verification are needed in the process, the existing HIFU treatment equipment and scientific research equipment are independent, and the pure HIFU treatment equipment aims at human body treatment, has high cost and cannot be well applied to scientific research and teaching tasks.
Disclosure of Invention
The present invention aims to solve at least one of the technical problems in the related art to some extent. Therefore, the invention aims to provide a focused ultrasonic scientific research platform suitable for scientific research and teaching.
The technical scheme adopted by the invention is as follows:
A focused ultrasound scientific research platform, comprising: the device comprises focusing ultrasonic equipment, an experiment operating table and a display device, wherein the focusing ultrasonic equipment is used for generating high-intensity focusing ultrasonic waves, the experiment operating table is used for fixing an experiment object, and the display device is used for capturing image information in the experiment process and displaying in a projection mode.
Further, the focused ultrasound apparatus includes: the system comprises an upper computer, a power source, a transducer unit, a positioning system and a three-dimensional motion control platform, wherein the output end of the upper computer is respectively connected with the input end of the power source and the input end of the three-dimensional motion control platform, the transducer unit is assembled on the three-dimensional motion control platform, the output end of the power source is connected with the input end of the transducer unit, and the positioning system is used for acquiring image information of a test process and transmitting the image information to the upper computer so as to monitor the test process.
Further, the focused ultrasound device further comprises an auxiliary system for preparing the medium water, and the transducer unit comprises a transducer module, and the transducer module is placed in the medium water.
Further, the power source comprises a signal source, a first-stage power amplification module and a second-stage power amplification module, wherein the input end of the signal source is connected with the output end of the upper computer, the output end of the signal source is connected with the input end of the first-stage power amplification module, the output end of the first-stage power amplification module is connected with the input end of the second-stage power amplification module, and the output end of the second-stage power amplification module is connected with the input end of the transducer unit.
Further, the transducer unit comprises: the transducer unit includes: the ultrasonic cavitation transducer comprises a HIFU thermal ablation transducer and/or an ultrasonic cavitation transducer, a wiring terminal, a first matching circuit and/or a second matching circuit, wherein the input end of the wiring terminal is connected with the output end of the power source, the output end of the wiring terminal is connected with the input end of the first matching circuit and/or the input end of the second matching circuit, the output end of the first matching circuit is connected with the input end of the HIFU thermal ablation transducer, and the output end of the second matching circuit is connected with the input end of the ultrasonic cavitation transducer.
Further, the positioning system comprises a B-ultrasonic instrument or a magnetic resonance imager, and the output control parameters of the upper computer and the transducer unit are adjusted according to the imaging result of the B-ultrasonic instrument or the magnetic resonance imager.
Further, the display device comprises a high-speed camera and a projector, the high-speed camera and the projector are respectively arranged on the experiment operation table, the high-speed camera is used for collecting image information in the experimental process, and the projector is used for amplifying the image information in the experimental process.
Further, the focusing ultrasonic equipment further comprises a direct current stabilized power supply, wherein the output end of the direct current stabilized power supply is connected with the input end of the power source, and the voltage of the direct current stabilized power supply is adjustable.
Further, the experiment operation table comprises an animal experiment clamp and a bionic system, wherein the animal experiment clamp is used for restraining animal actions and ensuring that experiments are carried out smoothly, and the bionic system is an experiment material and has acoustic characteristics and thermal characteristics similar to those of human tissues.
The beneficial effects of the invention are as follows:
The invention discloses a focused ultrasonic scientific research platform, which comprises the following components: the ultrasonic scientific research platform which is low in cost, complete in function and suitable for teaching is provided by organically combining the focused ultrasonic equipment, the experimental operation table and the display device.
Drawings
FIG. 1 is a schematic diagram of a focused ultrasound scientific research platform according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of an embodiment of a focused ultrasound apparatus in a focused ultrasound scientific research platform according to the present invention;
FIG. 3 is a schematic diagram of a transducer unit in a focused ultrasound scientific research platform according to an embodiment of the present invention;
Fig. 4 is a schematic structural diagram of a power source in a focused ultrasound scientific research platform according to an embodiment of the present invention.
Detailed Description
It should be noted that, without conflict, the embodiments of the present application and features of the embodiments may be combined with each other.
Referring to fig. 1, fig. 1 is a block diagram of a focused ultrasound scientific research platform according to an embodiment of the present invention, including: the device comprises focusing ultrasonic equipment, an experiment operating table and a display device, wherein the focusing ultrasonic equipment is used for generating high-intensity focusing ultrasonic waves, the experiment operating table is used for fixing an experiment object, and the display device is used for capturing image information in the experiment process and displaying in a projection mode. The output end of the generating device of the focusing ultrasonic equipment is erected above the experimental operation table, and the experimental operation table is connected with the display device.
The focusing ultrasonic equipment is used for positioning and destroying focus tissues, the experiment operation table comprises an animal clamping experiment clamp used for restraining animal behaviors or fixing in-vitro tissues so as to ensure that ultrasonic experiments are carried out smoothly, the display device is used for assisting teaching and demonstration, and specifically comprises a high-speed camera and a projector, the high-speed camera and the projector are respectively arranged on the experiment operation table in a supporting mode, the high-speed camera is used for collecting image information in the experimental process, and the projector is used for amplifying the image information in the collecting experimental process.
According to the embodiment, the ultrasonic scientific research platform which is low in cost, complete in function and suitable for teaching is provided by organically combining the focused ultrasonic equipment, the experimental operation table and the display device.
Specifically, as shown in fig. 2, fig. 2 is a schematic structural diagram of a focused ultrasound device in a focused ultrasound scientific research platform according to an embodiment of the present invention, where the focused ultrasound device includes: the system comprises an upper computer, a power source, a transducer unit, a positioning system and a three-dimensional motion control platform, wherein the output end of the upper computer is respectively connected with the input end of the power source and the input end of the three-dimensional motion control platform, the transducer unit is assembled on the three-dimensional motion control platform, the output end of the power source is connected with the input end of the transducer unit, and the positioning system is used for acquiring image information of a test process and transmitting the image information to the upper computer so as to monitor the test process.
The upper computer is used for outputting a treatment planning experiment scheme and transmitting the striking parameters to the power source through the serial port.
The power source receives the treatment parameters from the upper computer, generates an excitation signal and outputs the excitation signal to the transducer unit, and the transducer unit generates high-intensity focused ultrasound.
The direct current stabilized power supply is used for providing voltage in a corresponding treatment mode to the power source.
The transducer unit is assembled on the three-dimensional motion control platform, the upper computer drives the transducer unit through the three-dimensional motion control platform to realize accurate positioning, and the transducer unit and the three-dimensional motion control platform are in an assembling relationship and are detachable.
The auxiliary system is a medium water preparation device and is used for providing steam removal, automatic water pumping and self-service drainage, the energy converter unit comprises an energy converter module, the energy converter module is arranged in the medium water, and an ultrasonic transmission channel is optimized through the medium water, so that energy loss is reduced.
The positioning system is used for detecting the focusing dynamic information and feeding back to the upper computer. Specifically, the positioning system comprises a B-ultrasonic instrument or a magnetic resonance imager, and the output control parameters of the upper computer and the transducer unit are regulated according to the imaging result of the B-ultrasonic instrument or the magnetic resonance imager.
As shown in fig. 3, the transducer unit in this embodiment includes: the ultrasonic cavitation transducer comprises a HIFU thermal ablation transducer and/or an ultrasonic cavitation transducer, a wiring terminal, a first matching circuit and/or a second matching circuit, wherein the input end of the wiring terminal is connected with the output end of the power source, the output end of the wiring terminal is connected with the input end of the first matching circuit and/or the input end of the second matching circuit, the output end of the first matching circuit is connected with the input end of the HIFU thermal ablation transducer, and the output end of the second matching circuit is connected with the input end of the ultrasonic cavitation transducer.
The power source supports a HIFU thermal ablation mode and an ultrasonic cavitation mode, and the HIFU thermal ablation mode enables biological focus tissues to coagulate and necrotize through a thermal effect generated by the transducer; the ultrasonic cavitation mode bursts the inside of the biological focus tissue through cavitation effect generated by the transducer to form homogenate.
In the HIFU thermal ablation mode, a direct-current voltage stabilizing source outputs 40-100V voltage, a high-current signal output by a power source passes through a wiring terminal and a matching circuit to form a stable sine wave, the sine wave is loaded at two ends of the HIFU thermal ablation transducer, so that the ultrasonic transducer generates high-intensity ultrasonic waves, the ultrasonic waves penetrate through a coupling layer and enter normal tissues and are focused in focus tissues to form an ellipsoidal focal region, the temperature in the focal region is rapidly increased to more than 65 ℃, irreversible coagulation necrosis occurs to the tissues in the focal region, and the treatment purpose is achieved.
In the ultrasonic cavitation mode, a DC voltage stabilizing source outputs 150-250V voltage, a high-current signal output by a power source passes through a wiring terminal and a matching circuit to form stable pulse waves, the pulse waves are loaded on an ultrasonic cavitation transducer to generate high-intensity ultrasonic waves, the ultrasonic waves penetrate through a coupling layer to enter normal tissues and are focused in focus tissues to form an ellipsoidal focal region, and sound pressure in the focal region rapidly reaches an air threshold value to enable tissue cells to undergo a compression expansion process until finally burst to form tissue homogenate.
As shown in fig. 4, the power source includes a signal source, a first-stage power amplifier module and a second-stage power amplifier module, where an input end of the signal source is connected with an output end of the upper computer, an output end of the signal source is connected with an input end of the first-stage power amplifier, an output end of the first-stage power amplifier is connected with an input end of the second-stage power amplifier, and an output end of the second-stage power amplifier is connected with an input end of the transducer.
Only the modules of the focused ultrasound equipment necessary for scientific research and teaching are reserved, and the equipment cost can be obviously reduced.
The experiment operation table also comprises a bionic system, and a bionic simulation system, namely a bionic system, is constructed according to the structural characteristics, the acoustic characteristics and the thermal characteristics of a human body. The bionic system has acoustic characteristics and thermal characteristics similar to those of human tissues, and the output of the focused ultrasonic equipment acts on the bionic system to simulate the human treatment effect, so that the energy change rule of ultrasonic focusing is analyzed, and the safety and performance evaluation of ultrasonic focusing treatment dosage are realized.
While the preferred embodiment of the present application has been described in detail, the present application is not limited to the embodiments, and those skilled in the art can make various equivalent modifications or substitutions without departing from the spirit of the present application, and the equivalent modifications or substitutions are included in the scope of the present application as defined in the appended claims.
Claims (5)
1. The utility model provides a focused ultrasound scientific research platform which characterized in that includes: the device comprises a focusing ultrasonic device, an experiment operating table and a display device, wherein the focusing ultrasonic device is used for generating high-intensity focusing ultrasonic waves, the experiment operating table is used for fixing an experiment object, and the display device is used for capturing image information in the experiment process and projecting and displaying;
The display device comprises a high-speed camera and a projector, the high-speed camera and the projector are respectively arranged on the experiment operation table, the high-speed camera is used for collecting image information in the experiment process, and the projector is used for amplifying the image information in the collection experiment process;
The display device is used for assisting teaching and demonstration;
The focused ultrasound apparatus includes: the system comprises an upper computer, a power source, a transducer unit, a positioning system and a three-dimensional motion control platform, wherein the output end of the upper computer is respectively connected with the input end of the power source and the input end of the three-dimensional motion control platform, the transducer unit is assembled on the three-dimensional motion control platform, the output end of the power source is connected with the input end of the transducer unit, and the positioning system is used for acquiring image information of a test process and transmitting the image information to the upper computer so as to monitor the test process;
The transducer unit includes: the ultrasonic cavitation transducer comprises a HIFU thermal ablation transducer and/or an ultrasonic cavitation transducer, a wiring terminal, a first matching circuit and/or a second matching circuit, wherein the input end of the wiring terminal is connected with the output end of the power source, the output end of the wiring terminal is connected with the input end of the first matching circuit and/or the input end of the second matching circuit, the output end of the first matching circuit is connected with the input end of the HIFU thermal ablation transducer, and the output end of the second matching circuit is connected with the input end of the ultrasonic cavitation transducer;
the focused ultrasound device further comprises an auxiliary system for preparing medium water, wherein the transducer unit comprises a transducer module, and the transducer module is arranged in the medium water;
The auxiliary system is the medium water preparing device and is used for providing steam and water removal, automatic water pumping and self-service water drainage.
2. The focused ultrasound scientific research platform according to claim 1, wherein the power source comprises a signal source, a first-stage power amplification module and a second-stage power amplification module, the input end of the signal source is connected with the output end of the upper computer, the output end of the signal source is connected with the input end of the first-stage power amplification module, the output end of the first-stage power amplification module is connected with the input end of the second-stage power amplification module, and the output end of the second-stage power amplification module is connected with the input end of the transducer unit.
3. The focused ultrasound scientific research platform according to claim 1, wherein the positioning system comprises a B-ultrasonic instrument or a magnetic resonance imager, and the output control parameters of the upper computer and the transducer unit are adjusted according to the imaging result of the B-ultrasonic instrument or the magnetic resonance imager.
4. The focused ultrasound scientific research platform according to claim 1, wherein the focused ultrasound equipment further comprises a direct current stabilized power supply, an output end of the direct current stabilized power supply is connected with an input end of the power source, and a voltage of the direct current stabilized power supply is adjustable.
5. The focused ultrasound scientific research platform according to any one of claims 1 to 4, wherein the experiment operation table comprises an animal experiment clamp and a bionic system, the animal experiment clamp is used for restraining animal actions to ensure that experiments are carried out smoothly, and the bionic system is an experiment material and has acoustic characteristics and thermal characteristics similar to human tissues.
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| CN201910208512.XA CN109893785B (en) | 2019-03-19 | 2019-03-19 | Focused ultrasound scientific research platform |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1215616A (en) * | 1998-01-25 | 1999-05-05 | 重庆医科大学附属第二医院 | High-intensity focus supersonic tumor scanning therapy system |
| CN1456128A (en) * | 2002-05-10 | 2003-11-19 | 绵阳索尼克电子有限责任公司 | Focus ultrasonic knife for treating cancers |
| CN109173100A (en) * | 2018-10-17 | 2019-01-11 | 无锡海鹰医疗科技股份有限公司 | Have the focused ultrasound devices of two-dimensional imaging and HIFU Treatment one for toy |
| CN210750947U (en) * | 2019-03-19 | 2020-06-16 | 深圳市声科生物医学研究院 | Focused ultrasound scientific research platform |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100198065A1 (en) * | 2009-01-30 | 2010-08-05 | VyntronUS, Inc. | System and method for ultrasonically sensing and ablating tissue |
| CN102169108A (en) * | 2011-01-12 | 2011-08-31 | 四川大学 | Partially adjustable supersonic wave biological effect experiment loading device and supersonic wave loading method |
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- 2019-03-19 CN CN201910208512.XA patent/CN109893785B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1215616A (en) * | 1998-01-25 | 1999-05-05 | 重庆医科大学附属第二医院 | High-intensity focus supersonic tumor scanning therapy system |
| CN1456128A (en) * | 2002-05-10 | 2003-11-19 | 绵阳索尼克电子有限责任公司 | Focus ultrasonic knife for treating cancers |
| CN109173100A (en) * | 2018-10-17 | 2019-01-11 | 无锡海鹰医疗科技股份有限公司 | Have the focused ultrasound devices of two-dimensional imaging and HIFU Treatment one for toy |
| CN210750947U (en) * | 2019-03-19 | 2020-06-16 | 深圳市声科生物医学研究院 | Focused ultrasound scientific research platform |
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