CN109893626A - It is a kind of for treating the Chinese medicine composition of eczema - Google Patents
It is a kind of for treating the Chinese medicine composition of eczema Download PDFInfo
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- CN109893626A CN109893626A CN201910247981.2A CN201910247981A CN109893626A CN 109893626 A CN109893626 A CN 109893626A CN 201910247981 A CN201910247981 A CN 201910247981A CN 109893626 A CN109893626 A CN 109893626A
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Abstract
It is especially a kind of for treating the Chinese medicine composition of eczema the present invention relates to technical field of traditional Chinese medicine；The Chinese medicine composition is made of the natural drug composition of following parts by weight: 1 ~ 10 part of Cortex Phellodendri, 1 ~ 8 part of the tuber of stemona, 1 ~ 8 part of kuh-seng, 1 ~ 6 part of paniculate swallowwort, 0.1 ~ 0.2 part of borneol；Complex clinical test and pharmacological evaluation, drug of the invention have a good curative effect for eczema caused by treatment a variety of causes, and it is quick, cure rate is high, controls difficulty in relapse after healing.
Description
Technical field
It is especially a kind of for treating the Chinese medicine composition of eczema the present invention relates to technical field of traditional Chinese medicine.
Background technique
Eczema (alias: wet ulcer, English: Eczema) is the common epidermis as caused by a variety of internal and external factors of one kind and corium
The inflammatory dermatoses of shallow-layer.Head, the four limbs positions such as side and perineum in the wrong are mainly in, are often in general hair or symmetry distribution.It is clinical
Performance has the characteristics that symmetry, exudative, pruritus dermatopathy, pleomorphism and recurrent.Generally with the close phase of allergy
It closes.Part and endocrine dysfunction, vegetative nerve functional disturbance are related；Inherent cause is also one of this cause of disease element.A variety of diseases
Because more complicated, it is difficult to treat.
Treatment eczema mostly uses wipe outside the drug containing cortin greatly at present, and curative effect is affirmative, to mild or range
Small eczema can choose；The eczema of the eczema or recurrent exerbation big to area, if frequent or a large amount of or prolonged application contains skin
The drug of matter hormone has the side effect of whole body and local skin, including topical remedy's dependence facial dermatitis and rebound dermatitis, leads
It causes whole body class adrenal cortex function hyperfunction, induces digestive tract ulcer, hypertension and atherosclerosis etc..
Chinese medicine treatment eczema overcomes this drawback at present, treats more safe and secure.Chinese medicine thinks that eczema mainly has
Wind, cold, wet, dry, fiery, worm poison, wound, natural disposition is intolerant to, disharmony between ying and wei and visceral dysfunction hot and humid ecchymosis inner product, foreign aggression six
Excessive, climate change the change of living environment, internal damage by the excessive seven emotions, overworks, stress, emotional change, intra focal, metabolism
Obstacle.Endocrine disorder etc. is related.With internal heat spleen it is wet based on, it is raw in internal heat to cause blood-head because mind is fidgety, and can be because of intemperance of taking food
Or the product of overfeeding raw meat hair, injuring taste, the dysfunction of the spleen in transport is overflow from humorously, and it is wet mutually to fight with hot two heresy, it is altered under upper steaming, exuberant skin institute
It causes, lesion the disease being located in the exterior skin, but root is in blood.It is treated using Chinese medicine, it is without side-effects, it can achieve sample and grasp and control, thoroughly cure
Eczema.But the Chinese medicine of existing treatment eczema, specific aim is not strong, unsatisfactory curative effect.
Summary of the invention
In view of the above-mentioned problems existing in the prior art, the present invention provides a kind of Chinese medicine composition for treating eczema, in this
Drug composition can cure eczema and any side effect.
In order to solve the above technical problems, The technical solution adopted by the invention is as follows:
It is a kind of for treating the Chinese medicine composition of eczema, the Chinese medicine composition is combined by the natural drug of following parts by weight
Object composition: 1~10 part of Cortex Phellodendri, 1~8 part of the tuber of stemona, 1~8 part of kuh-seng, 1~6 part of paniculate swallowwort, 0.1~0.2 part of borneol.
Further, the Chinese medicine composition is made of the natural drug composition of following parts by weight: 10 parts of Cortex Phellodendri, the tuber of stemona
8 parts, 8 parts of kuh-seng, 5 parts of paniculate swallowwort, 0.1 part of borneol.
Further, the Chinese medicine composition is made of the natural drug composition of following parts by weight: 6 parts of Cortex Phellodendri, the tuber of stemona 6
Part, 6 parts of kuh-seng, 6 parts of paniculate swallowwort, 0.1 part of borneol.
Further, the Chinese medicine composition is made of the natural drug composition of following parts by weight: 5 parts of Cortex Phellodendri, the tuber of stemona 2
Part, 2 parts of kuh-seng, 5 parts of paniculate swallowwort, 0.2 part of borneol.
Further, the Chinese medicine composition further includes 4 parts of Chinese prickly ash.
Further, the Chinese medicine composition is made of the natural drug composition of following parts by weight: 10 parts of Cortex Phellodendri, hundred
8 parts of portion, 8 parts of kuh-seng, 5 parts of paniculate swallowwort, 4 parts of Chinese prickly ash, 0.2 part of borneol.
Further, the Chinese medicine composition further includes 6 parts of frutus cnidii.
Further, the Chinese medicine composition is made of the natural drug composition of following parts by weight: 10 parts of Cortex Phellodendri, hundred
8 parts of portion, 8 parts of kuh-seng, 5 parts of paniculate swallowwort, 6 parts of frutus cnidii, 0.2 part of borneol.
Cortex Phellodendri: it is bitter, cold, return kidney, bladder meridian, heat-clearing is dry, purging intense heat, except steaming, detoxification sore treatment, is monarch drug in a prescription.
The tuber of stemona: it is sweet, bitter, it is distributed in lung channel.Tepor, desinsection are ministerial drug.
Kuh-seng: bitter, cold, return heart, liver, stomach, large intestine, bladder meridian.Heat-clearing and damp-drying drug, desinsection are ministerial drug.
Paniculate swallowwort: it is pungent, warm, return liver, stomach meridian.Wind-dispelling dampness elimination, antalgesic-antipruritic are adjutant.
Borneol: pungent, bitter, slightly cold, return heart, spleen, lung channel.Clearing away heat to and alleviating pain, to make medicine.
The above five tastes enter conscience spleen and lung kidney the five internal organs, gather altogether purging fire for removing toxin, wind-dispelling dampness elimination, antalgesic-antipruritic, desinsection the effect of,
For treating the dysfunction of the spleen in transport, endogenous damp formation, wet accumulateing is fiery, and exogenous wind invasion with interior wet knot of fighting, accumulate the eczema generated in fleshy exterior.
It has a good effect.
If patient belongs to deficiency-cold in spleen and stomach person, can add Chinese prickly ash is adjutant.
Chinese prickly ash: pungent, warm, returns spleen, stomach, kidney channel.With the antipruritic effect of warm in pain, desinsection.
Such as patient's internal organs virtual loss, deficiency-cold in spleen and stomach, blood deficiency, wind formation from blood deficiency person are caused, can add frutus cnidii is adjutant.
Frutus cnidii: acrid, bitter, warm returns kidney channel.Eliminating dampness wind-dispelling, desinsection are antipruritic.For the eczema person that sees wind.
Complex clinical test and pharmacological evaluation, drug of the invention have very well eczema caused by treatment a variety of causes
Curative effect, and it is quick, cure rate is high, controls difficulty in relapse after healing.
It is using the beneficial effect of technical solution of the present invention:
Complex clinical test and pharmacological evaluation, drug of the invention have very well eczema caused by treatment a variety of causes
Curative effect, and it is quick, cure rate is high, controls difficulty in relapse after healing.
Specific embodiment
Below by specific embodiment, invention is further described in detail.Unless stated otherwise, embodiment party below
Technology used in formula is routine techniques known to those skilled in the art；Used instrument and equipment and reagent
Deng being that those skilled in the art can be by for example commercially available equal acquisitions of public approach.
Embodiment 1: a kind of Chinese medicine composition for treating eczema, Cortex Phellodendri 50g, tuber of stemona 40g, kuh-seng 40g, paniculate swallowwort 25g add
70% ethyl alcohol 300ml impregnates for 24 hours, and filtration takes filtrate, be added borneol 0.5g make dissolution to get.
Embodiment 2: a kind of Chinese medicine composition for treating eczema, Cortex Phellodendri 30g, tuber of stemona 30g, kuh-seng 30g, paniculate swallowwort 30g add
70% ethyl alcohol 300ml impregnates for 24 hours, and filtration takes filtrate, be added borneol 0.6g make dissolution to get.
Embodiment 3: a kind of Chinese medicine composition for treating eczema, Cortex Phellodendri 50g, tuber of stemona 20g, kuh-seng 20g, paniculate swallowwort 50g add
70% ethyl alcohol 300ml impregnates for 24 hours, and filtration takes filtrate, be added borneol 2g make dissolution to get.
Embodiment 4: a kind of Chinese medicine composition for treating eczema, Cortex Phellodendri 50g, tuber of stemona 40g, kuh-seng 40g, paniculate swallowwort 25g, flower
Green pepper 20g, adds 70% ethyl alcohol 300ml, impregnates for 24 hours, and filtration takes filtrate, be added borneol 1g make dissolution to get.
Embodiment 5: a kind of Chinese medicine composition for treating eczema, Cortex Phellodendri 50g, tuber of stemona 40g, kuh-seng 40g, paniculate swallowwort 25g, snake
Machine tool 30g, adds 70% ethyl alcohol 300ml, impregnates for 24 hours, and filtration takes filtrate, be added borneol 1g make dissolution to get.
Clinical application efficacy analysis:
Case 1: river, female, 1 years old.Its mother is fond of pungent object, and infant early stage Face and cheek plays red millet appearance skin
Rash has scratch, and big loose stool, tongue fur is white, is diagnosed as spleen deficiency damp-heat type eczema.Drug described in Example 1, because infant skin is tender
It is tender, with 3 times a day, affected part is put in painting on the skin after the dilution of appropriate cold water.After painting puts 1 day on the skin, itch significantly first less, eczema range no longer increases
Add, eczema range is reduced significantly after 3 days, and dry scab starts shedding off, spiritual amelioration, continues medication, further consultation again, decrustation are complete after 10 days
More.
Case 2: Huang, female, 7 years old.Early stage Face and cheek plays red millet appearance fash, clear water is oozed out after scratching, gradually
Chest and four limbs are spread to, haves the fidgets, is diagnosed as eczema.Drug described in Example 2,3 times a day, painting put affected part on the skin.It applies
After putting 1 day on the skin, itch significantly first less, eczema range be not further added by, eczema range is reduced significantly after 3 days, and dry scab starts shedding off, spirit
Amelioration continues medication, and further consultation again, decrustation are cured entirely after 10 days.
Case 3: Mr. Wang, male, 30 years old.Happiness is drunk, and back and four limbs play red millet appearance fash, oozes out clear water after scratching,
Surprise is itched unbearably, is examined as eczema.Drug described in Example 3,3 times a day, painting put affected part on the skin.After painting puts 1 day on the skin, itch is significantly first
It is few.Further consultation after 3 days, eczema range shorter, dry scab start shedding off.Continue medication, further consultation again, decrustation are cured entirely after 7 days.Advise patient
Be careful in one's diet habit, drinks less.
Case 4: Lee, female, 22 years old.Deficiency of food, frequent indigestion usually, with chilly, white and greasy fur, femoribus internus is moist
Have an itch, there is red papules and sepage, it is touching not to be cured, it examines as eczema.Drug described in Example 4,3 times a day, painting put affected part on the skin.
After painting puts 1 day on the skin, itch is significantly first few.Further consultation after 5 days, eczema range shorter, dry scab start shedding off.Continue medication, after 10 days again
Secondary further consultation, decrustation are cured entirely.
Case history 5: Mr. Wang, female, 45 years old.Four limbs play red millet appearance fash, the visible localized erythema of thigh axillary region, scratching
After ooze out clear water, conscious itch unbearably has scratch, to the wind or flu after aggravate, examine as eczema.Drug described in Example 5,
3 times a day, it applies and puts affected part on the skin.After painting puts 1 day on the skin, itch is significantly first few.Further consultation after 5 days, eczema range shorter, dry scab start shedding off.
Continue medication, further consultation again, decrustation are cured entirely after 10 days.
Experimental analysis is carried out to the curative effect of the traditional Chinese medicine for external application of the treatment eczema of the above embodiment of the present invention below:
Influence to chmice acute contact eczema model is investigated
1 experiment purpose
Above-described embodiment is observed to 1-CHLORO-2,4-DINITROBENZENE (DNCB) acetone soln induced mice acute contact eczema
Effect.
2 experimental methods
2.1 unhairing preserved skin methods
Groups of animals back was first pushed into hair with baby's electric hair in experiment first 1 day, then de- with 8% sodium sulfide solution
Hair, also variant (mouse: 2cm × 2cm) according to the different depilation areas of animal species, movement should be carefully soft when depilation, with
It is impaired to exempt from animal skin, is gently cleaned after depilation with warm water and removes hair-fields skin, checks afterwards go whether hair-fields skin has damage for 24 hours.
2.2 medication
After each group is applied relative medicine by the weight of animals outside 70% ethyl alcohol of weight such as (control group and model group) being coated with, in coating
Position applies nonirritant gauze, encloses above and below medical proof fabric around one after being fixed, then of corresponding size viscous back-to-back with area
The fixed entire coating area of adhesive tape pitch of the laps, and guarantee that drug comes into full contact with animal skin in 6h, coating drug removes medicine after reaching 6h
Object removes hair-fields skin with warm water cleaning.
2.3 specific tests
NIH mouse 80 are chosen, blank control group, model control group, mometasone furoate gel group, embodiment are randomly divided into
1,2,3,4,5 groups, every group 10.Mometasone furoate gel group 2.500g gel kg-1, each embodiment are 0.5g containing crude drug
Crude drug/ml, according to method preserved skin, the topical application of drug and the fixation of " 2.1 and 2.2 ", groups of animals adjusts coating relative medicine according to weight
It measures, removes drug after 6h, hair-fields skin is gone with warm water cleaning.1 time a day, continuous 11d.Blank control group, model control group are same
Method applies 70% ethyl alcohol.
1d each group (in addition to blank control group) is tested in going to hair-fields to be coated with 7%DNCB liquid (acetone: peanut oil=4:1)
100 μ L sensitization 1 time.6d is tested, each group (in addition to blank control group) applies 10 μ L of 1%DNCB acetone solution and swashs on the inside of mouse right ear
Hair excited 1 time, 3 times totally every 2 days.Mouse is put to death for 24 hours after the 3rd excitation, is made ear device with diameter 8mm auricle and is removed left and right
Auricle is weighed and is calculated according to formula one and two, using auricle swelling degree as chmice acute contact eczema response value, system
Meter analysis each group of data difference.
Acute contact eczema response value=auricle swelling degree=auris dextra weight-left ear weight
Inhibiting rate=(administration group response value-model group response value)/model group response value × 100%
2.4 experimental result
Table 1 the result shows that, compared with blank control group, the response value of model control group murine contact eczema is significantly increased
(P<0.01)；Compared with model control group, the response value of Examples 1 to 5 group murine contact eczema be substantially reduced (P <
0.05).There was no significant difference (P > 0.05) with mometasone furoate gel group for Examples 1 to 5 group response value.
Table 1 to chmice acute contact eczema influence (N=10)
Note: 1. compared with blank control group, P < 0.01 * P < 0.05, * *；Compared with model control group, #P < 0.05, ##P <
0.01.2. compared with momestasone furoate group, P < 0.01 △ P < 0.05, △ △.
2.5 experiment conclusion
The response value of the substantially reduced DNCB induced mice acute contact eczema of each embodiment energy, inhibiting rate are more than
30%.
Taking the above-mentioned ideal embodiment according to the present invention as inspiration, through the above description, relevant staff is complete
Various changes and amendments can be carried out without departing from the scope of the technological thought of the present invention' entirely.It is all in essence of the invention
Within mind and principle, any modification, equivalent substitution, improvement and etc. done be should all be included in the protection scope of the present invention.This
The technical scope of item invention is not limited to the contents of the specification, it is necessary to its technology is determined according to scope of the claims
Property range.
Claims (8)
1. a kind of for treating the Chinese medicine composition of eczema, it is characterised in that: the Chinese medicine composition by following parts by weight day
Right pharmaceutical composition composition: 1 ~ 10 part of Cortex Phellodendri, 1 ~ 8 part of the tuber of stemona, 1 ~ 8 part of kuh-seng, 1 ~ 6 part of paniculate swallowwort, 0.1 ~ 0.2 part of borneol.
2. according to claim 1 a kind of for treating the Chinese medicine composition of eczema, it is characterised in that: the Chinese traditional medicine composition
Object is made of the natural drug composition of following parts by weight: 10 parts of Cortex Phellodendri, 8 parts of the tuber of stemona, 8 parts of kuh-seng, 5 parts of paniculate swallowwort, borneol 0.1
Part.
3. according to claim 1 a kind of for treating the Chinese medicine composition of eczema, it is characterised in that: the Chinese traditional medicine composition
Object is made of the natural drug composition of following parts by weight: 6 parts of Cortex Phellodendri, 6 parts of the tuber of stemona, 6 parts of kuh-seng, 6 parts of paniculate swallowwort, borneol 0.1
Part.
4. according to claim 1 a kind of for treating the Chinese medicine composition of eczema, it is characterised in that: the Chinese traditional medicine composition
Object is made of the natural drug composition of following parts by weight: 5 parts of Cortex Phellodendri, 2 parts of the tuber of stemona, 2 parts of kuh-seng, 5 parts of paniculate swallowwort, borneol 0.2
Part.
5. according to claim 1 a kind of for treating the Chinese medicine composition of eczema, it is characterised in that: the Chinese traditional medicine composition
Object further includes 4 parts of Chinese prickly ash.
6. according to claim 5 a kind of for treating the Chinese medicine composition of eczema, it is characterised in that: the Chinese traditional medicine composition
Object is made of the natural drug composition of following parts by weight: 10 parts of Cortex Phellodendri, 8 parts of the tuber of stemona, 8 parts of kuh-seng, 5 parts of paniculate swallowwort, Chinese prickly ash 4
Part, 0.2 part of borneol.
7. according to claim 1 a kind of for treating the Chinese medicine composition of eczema, it is characterised in that: the Chinese traditional medicine composition
Object further includes 6 parts of frutus cnidii.
8. according to claim 7 a kind of for treating the Chinese medicine composition of eczema, it is characterised in that: the Chinese traditional medicine composition
Object is made of the natural drug composition of following parts by weight: 10 parts of Cortex Phellodendri, 8 parts of the tuber of stemona, 8 parts of kuh-seng, 5 parts of paniculate swallowwort, frutus cnidii 6
Part, 0.2 part of borneol.
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| CN201910247981.2A CN109893626A (en) | 2019-03-29 | 2019-03-29 | It is a kind of for treating the Chinese medicine composition of eczema |
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| CN201910247981.2A CN109893626A (en) | 2019-03-29 | 2019-03-29 | It is a kind of for treating the Chinese medicine composition of eczema |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110604768A (en) * | 2019-09-29 | 2019-12-24 | 杨淑明 | Composition for treating eczema dermatitis |
| CN111067961A (en) * | 2020-01-17 | 2020-04-28 | 北京中医药大学 | Traditional Chinese medicine composition for treating eczema and preparation method thereof |
-
2019
- 2019-03-29 CN CN201910247981.2A patent/CN109893626A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 张正伟等: "中药薰洗治疗皮肤瘙痒162例", 《中国现代药物应用》 * |
| 黄洪坤: "穴注药物加苦柏合剂熏洗治疗肛门湿疹及双下肢顽固性湿疹20例疗效观察", 《广州医药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110604768A (en) * | 2019-09-29 | 2019-12-24 | 杨淑明 | Composition for treating eczema dermatitis |
| CN111067961A (en) * | 2020-01-17 | 2020-04-28 | 北京中医药大学 | Traditional Chinese medicine composition for treating eczema and preparation method thereof |
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Application publication date: 20190618 |