CN109893545A - A kind of polysaccharide Chinese medicine combination preparation for treating virus - Google Patents
A kind of polysaccharide Chinese medicine combination preparation for treating virus Download PDFInfo
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- CN109893545A CN109893545A CN201711307266.0A CN201711307266A CN109893545A CN 109893545 A CN109893545 A CN 109893545A CN 201711307266 A CN201711307266 A CN 201711307266A CN 109893545 A CN109893545 A CN 109893545A
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- calcium
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Abstract
A kind of polysaccharide Chinese medicine combination preparation for treating virus.The present invention is to combine aminoglycan under conditions of pH2.7 to pH5.7 under the action of catalyst with Chinese medicine manufactured composition, and composition significantly improves the validity of disease caused by Chinese medicine treatment human body and animal virus.
Description
Technical field
The present invention relates to biomedicine fields, specifically, be biological agent preparation and its treatment skin disease on
Application.
Background technique
Human body caused by virus and Animal diseases threaten increasingly serious, Er Qieren to human health and aquaculture bring
Poultry suffers from the disease altogether, mainly has virus to cause.In human history, the society and economic loss that viral disease causes are very tight
Weight.Only influenza virus just constitutes very big threat to the life and health of the mankind, in recent years global annual Influenza Outbreak
Infecting case is more than 1,000,000,000 people.
China has summed up many for treating the Chinese herbal and crude drugs preparations of human body diseases in thousands of years development of civilization histories.
As a kind of patent application " preparation method for treating cold medicine " of publication number CN101468156A discloses one kind by flutterring hot breath
Bitterly, campanulaceae, Fructus Forsythiae, Fermented Soybean, Radix Glycyrrhizae, henon bamboo；The patent application of publication number CN1425449A is " a kind of to treat in anemopyretic cold
Drug composition and preparation method thereof " discloses one kind by radix bupleuri, honeysuckle flower, radix scutellariae, pueraria lobata, schizonepeta, sweet wormwood, Fructus Forsythiae, campanulaceae, apricot
Oral preparation made of benevolence, peppermint and cordate houttuynia.The patent application of publication number CN1883651A is " a kind of to treat in anemopyretic cold
Drug composition and preparation method thereof " disclose it is a kind of by radix bupleuri, radix scutellariae, gypsum, sweet wormwood, isatis root, honeysuckle flower, rheum officinale, dandelion,
Oral preparation made of rhizoma anemarrhenae and Fructus Forsythiae, for treating flu caused by influenza virus.Wherein Radix Isatidis is as traditional heat-clearing solution
Malicious Chinese medicine, antiviral activity, and it is adjustable body's immunity, there is certain antiviral activity.But up to now, clinically
Still lack safe and effective and economical and practical antiviral drugs.
Summary of the invention
The endpoint of disclosed range and any value are not limited to the accurate range or value herein, these ranges or
Value should be understood as comprising the value close to these ranges or value.For numberical range, between the endpoint value of each range, respectively
It can be combined with each other between the endpoint value of a range and individual point value, and individually between point value and obtain one or more
New numberical range, these numberical ranges should be considered as specific open herein.
For overcome the deficiencies in the prior art, the present invention is by aminoglycan and Chinese medicine under the action of catalyst in pH2.7
Biological agent made of being combined under conditions of to pH5.7, as the group for being applied to disease caused by treatment human body and animal virus
Close preparation.
The aminoglycan of selection is to constitute the base of these glycan by the polysaccharide being polymerize by 2-7000 monosaccharide containing amino
Plinth molecular formula is the monosaccharide of 6 carbon atoms, can come from plant, animal or microorganism, including but not limited to: glycosaminoglycan,
Amino-oligosacchride, chitosan, glycosaminoglycan, chitosan, astragalus polyose, panaxan, notoginseng polysaccharide, dictyophora fungus polysaccharide, ganoderma lucidum are more
At least one of sugar and zymosan.Most preferably, the aminoglycan is amino-oligosacchride.
The Chinese medicine of selection includes but is not limited to radix bupleuri, radix scutellariae, gypsum, sweet wormwood, isatis root, honeysuckle flower, rheum officinale, Pu Gong
English, rhizoma anemarrhenae, Fructus Forsythiae, pueraria lobata, honeysuckle flower, schizonepeta, cape jasmine, Fructus Forsythiae, radix scrophulariae, bombyx batryticatus, Radix Rehmanniae, campanulaceae, peppermint, cicada slough, radix saposhnikoviae and sweet
One or more manufactured preparations of grass.More preferably schizonepeta, campanulaceae, isatis root, radix bupleuri, pueraria lobata, radix saposhnikoviae and Radix Glycyrrhizae system
At preparation.
In the present invention, the catalyst includes inorganic compound or biocatalyst, it is preferable that including but not limited to,
Calcium chloride, sodium chloride, potassium chloride, zinc oxide, calcium oxide, calcium superphosphate, sodium tripolyphosphate, sodium bicarbonate, sodium polyphosphate, di(2-ethylhexyl)phosphate
Hydrogen potassium, dipotassium hydrogen phosphate, disodium-hydrogen, sodium sulphate, zinc sulfate, copper sulphate, zinc acetate, potassium sulfate, calcium carbonate, amino acid
Calcium, amino-acid zinc, glucan calcium, glucan zinc, sodium carbonate, calcium bicarbonate, saleratus, calcium sulfate, calcium nitrate, glucose
In calcium, potassium carbonate, Bacillus acidi lactici, bacillus, Lactococcus, Bacillus acidi lactici, saccharomycete, biological enzyme and pseudomonad at least
It is a kind of.The more preferably biocatalyst of Bacillus acidi lactici and saccharomycetes to make fermentation liquid.
The material of above-mentioned material composition used can be commercially.
The polysaccharide Chinese medicine combination preparation for the treatment of virus provided by the invention is by aminoglycan and Chinese medicine containing catalysis
PH is combined under conditions of being 2.7-5.7 and is made in the liquid of agent.
The present invention also provides the applications of above-mentioned viral therapy.
In the present invention, the human body or animal virus addressed include but is not limited to influenza virus, hepatitis virus, herpesviral
Deng.
Present invention solves the technical problem that being that aminoglycan and Chinese medicine are made in the fermentation liquid of Bacillus acidi lactici and saccharomycete
The combination preparation obtained.This preparation can be used for human body or Animal diseases caused by treating virus.
Innovative point of the invention is will be containing the polysaccharide and one or more Chinese medicines that the monosaccharide of the 2-7000 of amino polymerize
There is the combination preparation of synergistic function, this preparation can be used for made of in the fermentation liquid of Bacillus acidi lactici and saccharomycete
Disease caused by treatment virus.
Specific embodiment
The present invention is further described according to following examples, one skilled in the art will appreciate that following embodiments are to this hair
The bright effect for functioning only as explanation.Without departing from the premise in the spirit of the present invention, any improvement and the substitution present invention done
Within the protection scope of the present invention.
Embodiment 1
Fermentation liquid preparation: saccharomycete is cultivated 48 hours at MEB culture medium, 28 DEG C, cell concentration reaches 5.1 x 109
cfu/ml.Bacillus acidi lactici is cultivated 48 hours at 28 DEG C of LB culture medium, cell concentration reaches 3.6 x 1010cfu/ml.By ferment
Female fermented liquid is mixed with lactobacillus fermentation liquid by 2:1, shakes up and 1000 milliliters of mixed fermentation liquids are made, and amino-oligosacchride 6 is added
Gram, it being sufficiently mixed uniformly, 1000 milliliters of medical fluid that Chinese medicine tanning is added are sufficiently mixed uniformly, it cultivates 24 hours, spray drying,
Aminoglycan Chinese medicine antiviral compound preparation is made.
Claims (8)
1. a kind of polysaccharide Chinese medicine combination preparation for treating virus, which is characterized in that by aminoglycan and Chinese medicine in catalyst
Under effect under conditions of pH2.7 to pH5.7 combine made of composition, composition significantly improve Chinese medicine treatment human body and
The validity of disease caused by animal virus.
2. composition according to claim 1, wherein the aminoglycan be by containing amino by 2-7000 monosaccharide
The polysaccharide of polymerization, the base molecule formula for constituting these glycan is the monosaccharide of 6 carbon atoms, can come from plant, animal or micro- life
Object, including but not limited to: glycosaminoglycan, amino-oligosacchride, chitosan, glycosaminoglycan, chitosan, astragalus polyose, ginseng are more
Sugar, notoginseng polysaccharide, dictyophora fungus polysaccharide, at least one of ganoderma lucidum polysaccharide and zymosan, it is more preferred to amino-oligosacchride.
3. composition according to claim 1, wherein the Chinese medicine include but is not limited to radix bupleuri, radix scutellariae, gypsum,
Sweet wormwood, isatis root, honeysuckle flower, rheum officinale, dandelion, rhizoma anemarrhenae, Fructus Forsythiae, pueraria lobata, honeysuckle flower, schizonepeta, cape jasmine, Fructus Forsythiae, radix scrophulariae, bombyx batryticatus, life
Ground, campanulaceae, peppermint, cicada slough, radix saposhnikoviae and one or more manufactured preparations of Radix Glycyrrhizae.
4. more preferably preparation made of schizonepeta, campanulaceae, isatis root, radix bupleuri, pueraria lobata, radix saposhnikoviae and Radix Glycyrrhizae.
5. composition according to claim 1, wherein the human body or animal virus include but is not limited to influenza disease
Poison, hepatitis virus, herpesviral etc..
6. composition according to claim 1, wherein the catalyst includes but is not limited to: inorganic compound and/or
Biocatalyst.
7. composition according to claim 5, wherein the catalyst includes but is not limited to calcium chloride, sodium chloride, chlorine
Change potassium, zinc oxide, calcium oxide, calcium superphosphate, sodium tripolyphosphate, sodium bicarbonate, sodium polyphosphate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate,
Disodium-hydrogen, sodium sulphate, zinc sulfate, copper sulphate, zinc acetate, potassium sulfate, calcium carbonate, amino acid calcium, amino-acid zinc, glucan
Calcium, glucan zinc, sodium carbonate, calcium bicarbonate, saleratus, calcium sulfate, calcium nitrate, calisanin, potassium carbonate, Bacillus acidi lactici,
At least one of bacillus, Lactococcus, leukonid, saccharomycete, biological enzyme and pseudomonad.
8. more preferably saccharomycete and lactobacillus fermentation liquid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711307266.0A CN109893545A (en) | 2017-12-11 | 2017-12-11 | A kind of polysaccharide Chinese medicine combination preparation for treating virus |
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| CN201711307266.0A CN109893545A (en) | 2017-12-11 | 2017-12-11 | A kind of polysaccharide Chinese medicine combination preparation for treating virus |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112336788A (en) * | 2019-08-09 | 2021-02-09 | 成都澳立生态科技发展有限公司 | Composition for improving sleep quality |
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2017
- 2017-12-11 CN CN201711307266.0A patent/CN109893545A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112336788A (en) * | 2019-08-09 | 2021-02-09 | 成都澳立生态科技发展有限公司 | Composition for improving sleep quality |
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Application publication date: 20190618 |
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