CN109893309A - The degradable esophagus pipe holder of the antiskid self expandable of negative poisson's ratio structure and its preparation - Google Patents
The degradable esophagus pipe holder of the antiskid self expandable of negative poisson's ratio structure and its preparation Download PDFInfo
- Publication number
- CN109893309A CN109893309A CN201910162678.2A CN201910162678A CN109893309A CN 109893309 A CN109893309 A CN 109893309A CN 201910162678 A CN201910162678 A CN 201910162678A CN 109893309 A CN109893309 A CN 109893309A
- Authority
- CN
- China
- Prior art keywords
- negative poisson
- degradable
- rack body
- pipe holder
- ratio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Media Introduction/Drainage Providing Device (AREA)
- Prostheses (AREA)
Abstract
The present invention provides a kind of degradable esophagus pipe holders of the antiskid self expandable of negative poisson's ratio structure, it is characterized in that, including the rack body made of all or part of degradable material, the rack body includes sequentially connected upper end, middle part and lower end, the top of upper end and the bottom end of lower end are respectively formed upper port and lower port, and the internal diameter of upper port and lower port is all greater than the internal diameter at the middle part.The present invention can utilize Negative poisson's ratio, realize the minimally invasive implantation of esophagus pipe holder, esophageal wall uniform stressed effectively avoids damage to and avoids stent migration without axial shrinkage during stent expansion;Negative poisson's ratio structure meets patient during feed is swallowed simultaneously, and for bracket while avoiding displacement, the radial process of bracket can reduce the discomfort of patients diet's process.The problems such as present invention independently gradually expands under dynamic excitation and biodegradable, effectively avoids in-stent restenosis and further takes out difficulty after being implanted into.
Description
Technical field
The present invention relates to a kind of degradable esophagus pipe holder of the antiskid self expandable of negative poisson's ratio structure and its preparations.
Background technique
Current clinically common esophagus pipe holder can substantially be divided into three classes according to the use of material: metallic support, high
Molecularly Imprinted Polymer bracket and compound bracket;According to whether overlay film is divided into naked bracket, part overlay film frame and full overlay film frame,
According to whether degradable be divided into permanent support and biodegradable stent.
The clinical application course of metallic support at most, from the stainless steel stent of early stage, is closed to memory mature at present
Golden bracket has many advantages, such as intensity height, and shape-retaining ability is good, but has biocompatibility poor simultaneously, and when taking-up will cause secondary wound
The defects of hurting.
Biodegradable stent usually select through FDA certification degradation material such as polycaprolactone (polycaprolactone,
PCL), polyglycolic acid (Polyglycolic acid, PGA), polydioxanone (Poly (p-dioxanone), PPDO)
It is prepared with materials such as polylactic acid (Polylactic acid, PLA).
Compound bracket is generally to be aided with coated by high-molecular film based on metallic support to the integrated application of two kinds of materials.
Researcher carries out purposive exploitation also directed to different clinical pathologies, there is the bracket for eluting medicament of drug slow release function, additional to put
The anti-cancer of the esophagus bracket of penetrating property, the self-expandable stent etc. with anti back-flow valve.
Existing Esophageal Stent will receive food to its shearing stress, in the effect of shearing stress during patients diet
Under, the diameter of bracket can reduce, so that bracket is easy sliding, while when patient swallows may experience discomfort.
Summary of the invention
The purpose of the present invention is to provide a kind of tool Negative poisson's ratio and the Esophageal Stent of degradable function is had both, it is main
Solve the problems, such as Esophageal Stent easily shift or slip and non-degradation material caused by complication obviously and later period taking-up difficulty etc.
Problem.
In order to achieve the above object, the present invention provides a kind of degradable esophaguses of antiskid self expandable of negative poisson's ratio structure
Pipe holder, which is characterized in that including the rack body made of all or part of degradable material, the rack body packet
Sequentially connected upper end, middle part and lower end are included, the top of upper end and the bottom end of lower end are respectively formed upper port
And lower port, the internal diameter (interior diameter) of upper port and lower port are all greater than the internal diameter (interior diameter) at the middle part.
Preferably, the middle part of the rack body or all with negative poisson's ratio.
Preferably, the rack body is tubular structure.
Preferably, the upper and lower end is in the shape of a trumpet.
Preferably, the total length of the rack body is 40~80mm, and the internal diameter at the middle part of the rack body is (interior
Diameter) it is 16~18mm, upper port is concordant with the section of lower port, and the internal diameter (interior diameter) of upper port and lower port is 20~
24mm。
Preferably, it the middle part of the rack body or is all made of the structural unit with negative poisson's ratio.
Preferably, developer, drug or radioactive particle are contained in the material of the rack body.
The present invention also provides the preparations of the degradable esophagus pipe holder of the antiskid self expandable of above-mentioned negative poisson's ratio structure
Method characterized by comprising
Step 1: using the middle part of Three-dimensional warp knitting interval needle technology braided support main body;
Step 2: supportting the form for maintaining the middle part of rack body with ring steel, PE cylindrical body is woven in using circular knitting machine
Upper braiding upper and lower end, wherein upper end, lower end and the central integration of the rack body;
Step 3: carrying out thermal finalization processing, obtain the degradable esophagus pipe holder of antiskid self expandable of negative poisson's ratio structure.
Preferably, upper end and lower end are adjusted by adjusting ring steel support with PE cylindrical body spacing in the step 2
The length in portion.
Preferably, during the braiding of the step 1, successively horizontal sawtooth shape arranges to be formed with negative pool positive and negative coil
The tubular structure of loose ratio.
Preferably, the heat setting temperature is 85-95 DEG C, and the time is 0.5-1.5 hours.
The degradable esophagus pipe holder of the self expandable antiskid of negative poisson's ratio structure of the invention is thick by both ends, intermediate slightly thin
Three sections it is smooth be formed by connecting, the transition portion of thickness section expands shape in horn mouth.Positive and negative coil as structural unit is successively
When horizontal sawtooth shape arranges and forms tubular structure, the product with negative poisson's ratio performance is obtained.
Compared with prior art, the beneficial effects of the present invention are:
1, bracket of the present invention has self-expanding, and when implantation is compressible, facilitates implantation oesophagus.After implantation based on itself from
Dilatancy and bounce expansion.
2, bracket of the present invention has axial negative poisson's ratio characteristic, and esophageal peristalsis drives food folding process, food when swallowing
Make its axially loaded with bracket wall friction, causes order at the point of contact of positive and negative coil to pull down, as a result bracket more attaches oesophagus
Wall significantly reduces during swallowing because of a possibility that the bracket sliding caused by esophageal peristalsis and food factor.
3, the end diameter of bracket of the present invention is greater than mid diameter, makes it at lemostenosis and normal place's smooth transition,
More attach esophageal wall.The possibility of stent migration and slippage is also further reduced simultaneously.
4, bracket of the present invention prepares at the middle part of bracket with upper/lower terminal portion by being segmented integrally formed method respectively,
Obtain the degradable esophagus pipe holder of antiskid self expandable of negative poisson's ratio structure, and in the way of thermal finalization center rest knot
Structure.Have both again while having ensured good radial support power by biodegradability, by adjust high molecular material at
Divide and degradation time is adjusted to control the decomposition of bracket in ratio.It is difficult that its degradability overcomes the taking-up of permanent stents later period
Deng limitation.Material has good biocompatibility simultaneously, further reduces the possibility for causing complication.Particularly, good
Property oesophagus tumor caused by stenosis apply, remodeling (or purpose needed for other clinics) is completed at lemostenosis position after certain period,
Bracket, which is slowly degraded, during it makes its mechanical property reach critical, is gradually fragmented into small pieces, and enter with certain feeding activities
Until excreting in subsequent alimentary canal.
5, bracket expansibility of the present invention is strong, cost performance is high.The objects such as developer can be added when preparing weaving fiber (material)
Matter, and can be further processed and make its medicine-carried, radioactive particle etc., or surface coating etc. is carried out to it.
6, for the present invention based on negative poisson's ratio structural unit, design is radial and axially has the oesophagus of Negative poisson's ratio
Rack body position, both side ends expand the trend that section itself is expanded outward using bracket and are fixed on oesophagus using structure is expanded
To reduce stent migration on wall, while the esophageal stents main paragraph of negative poisson's ratio structure plays the role of expanding esophageal stricture;Then,
Using Three-dimensional warp knitting interval needle technology knitting forming method;Finally, the performance of test Esophageal Stent;Using Negative poisson's ratio,
Realize the minimally invasive implantation of esophagus pipe holder, esophageal wall uniform stressed effectively avoids damage to and do not have axial receive during stent expansion
Contracting avoids stent migration;Simultaneously negative poisson's ratio structure meet patient during feed is swallowed, bracket avoid displacement while,
The radial process of bracket can reduce the discomfort of patients diet's process.The degradable esophagus pipe holder of self expandable is autonomous in the case where outer boundary motivates
It gradually expands and biodegradable, effectively avoids the problems such as further taking out difficulty after in-stent restenosis and implantation.
Detailed description of the invention
Fig. 1 is the overall structure diagram of bracket of the present invention;
Fig. 2 is rack body structural unit schematic diagram.
Specific embodiment
Present invention will be further explained below with reference to specific examples.It should be understood that these embodiments are merely to illustrate the present invention
Rather than it limits the scope of the invention.In addition, it should also be understood that, after reading the content taught by the present invention, those skilled in the art
Member can make various changes or modifications the present invention, and such equivalent forms equally fall within the application the appended claims and limited
Range.
The preparation method of the PCL multifilament looping PPDO monofilament of load medicine (Rabdosia rubescens active constituent KY3) in following embodiment
Are as follows:
The preparation of PCL multifilament looping PPDO monofilament: it is mono- that 4 PCL multifilament are uniformly coated on PPDO using weaving
Silk table face obtains PPDOCY.It the use of PPDO monofilament is middle mandrel yarn using C12 ingot braider, four ingot PCL multifilament are equal around axis yarn
It is even to be placed on braiding track, it is woven after all yarns are connected with drawing loading.In PPDOCYBraiding preparation process
In, draw rate is reduced by control appropriateness and obtains biggish count, so that the braiding clad structure of PCL is even closer.
Observe the PPDO of knitting formingCY, PCL multifilament forms apparent braiding structure in PPDO monofilament surface, and covered effect is close.Make
It is measured with MB-Ruler, measuring PPDO filament diameter is 0.23 ± 0.02mm, PPDOCYThe diameter of wrap yarn be 0.32 ±
0.01mm.(Wu Siwei, the design and preparation of self-reinforcing artificial esophagus's stand tube, [D], 2018.)
The solution for the Rabdosia rubescens active constituent KY3 that concentration is 30 μm of ol/l is coated on bracket, 40 DEG C dry 30 minutes,
Obtain carrying the PCL multifilament looping PPDO of medicine (Rabdosia rubescens active constituent KY3).
The Three-dimensional warp knitting interval needle technology knitting skill that preparation uses in the middle part of rack body in following embodiment is with reference to text
It offers: Ma Pibo, Chang Yuping, Jiang Gaoming negative poisson's ratio knitted structure and its application [J] weaving Leader, 2015,7,47-50.
Rack body upper/lower terminal portion in following embodiment uses the method bibliography worked out: Wu Siwei, self-reinforcing
The design and preparation of artificial esophagus's stand tube, D, 2018.
Embodiment 1
As shown in Figure 1, the degradable esophagus pipe holder of the antiskid self expandable of the negative poisson's ratio structure of the present embodiment includes pipe
The rack body of shape, the rack body include sequentially connected upper end 1, middle part 2 and lower end 3, the top of upper end 1
The bottom end of end and lower end 3 is respectively formed upper port and lower port, and the internal diameter (interior diameter) of upper port and lower port is all greater than
The internal diameter (interior diameter) at the middle part 2.To realize radial support effect, expand its both ends, upper and lower end is in loudspeaker
Mouth shape is changeover portion between middle part 2 and upper and lower port.
The rack body passes through weaving by the PCL multifilament looping PPDO monofilament of load medicine (Rabdosia rubescens active constituent KY3)
Means building.There is negative poisson's ratio in the middle part of the rack body.The upper port of the rack body and the section of lower port
Concordantly, the internal diameter (interior diameter) of upper port and lower port is 20mm.Food meatus stent length is adjusted according to affected part in 40-80mm
Between, in addition to that cannot use at the food meatus tumour of throat, remaining position be can be used.
The preparation method of the degradable esophagus pipe holder of the antiskid self expandable of above-mentioned negative poisson's ratio structure, specific steps
Are as follows:
Step 1: using the middle part of Three-dimensional warp knitting interval needle technology braided support main body, middle part is by negative poisson's ratio structure list
The PCL multifilament looping PPDO monofilament straight pipe for the load medicine (Rabdosia rubescens active constituent KY3) that member 21 is constituted, straight pipe interior diameter
16mm, length are preferably 40mm, are woven using Three-dimensional warp knitting interval needle technology, pay attention to respectively retaining the free yarn of 100mm at both ends
Section, the reserved material as upper and lower ends braiding.During the braiding of the step 1, positive and negative coil successively horizontal sawtooth shape
Arrangement forms the tubular structure with negative poisson's ratio.As shown in Fig. 2, the structural unit 21 is by positive coil 11, reverse line
Successively horizontal sawtooth shape arranges and connects formation in tie point 13 circle 12, and rack body has negative poisson's ratio in the axial direction.
Step 2: after completing middle part weaving, the form for maintaining the middle part of rack body is supportted with ring steel, using annular weaving
Machine weaves upper and lower end (not having above structure unit 21) on the PE cylindrical body that diameter is 20mm.The bracket
Upper end, lower end and the central integration of main body;The changeover portion projected length between middle part and upper and lower port is kept to exist
5mm ± 0.03mm can adjust the length of upper and lower end by adjusting ring steel support and PE cylindrical body spacing.Above and below
The length of end is preferably 8mm.
Step 3: using the structure of thermal finalization processing center rest, heat setting temperature is 90 DEG C, and the time is 1 hour, is obtained
The degradable esophagus pipe holder of the antiskid self expandable of negative poisson's ratio structure.
The present invention is in use, by narrow section in food meatus stenter to implant food meatus, the upper/lower terminal portion of esophagus pipe holder
Narrow section both ends are located at, the process to implant can suitably be compressed, and place affected part and finish, the self-expanding of itself can support
Stenosis is played, so that patient can normally feed digestion, the compatibility of the good radial support power of bracket and good biology is convenient for
Close to attach esophageal wall, simultaneously because the design of negative poisson's ratio structure, in swallowing activity, esophageal peristalsis drives and moves past under food
Journey, cradle wall axially loaded, order drop-down at the point of contact of positive and negative coil in structural unit, bracket ring-type perimeter increases, section
Area increases, and radial expansion force causes bracket that can more attach esophageal wall.Significantly reduce shipper pole under esophageal peristalsis and food
A possibility that stent migration come.
According to above-described embodiment, the present invention can be realized well.Be worth explanation when based on the more of negative poisson's ratio structure
Sample, the implementation of similar structures can all come therefrom.
Embodiment 2
As shown in Figure 1, the degradable esophagus pipe holder of the antiskid self expandable of the negative poisson's ratio structure of the present embodiment includes pipe
The rack body of shape, the rack body include sequentially connected upper end 1, middle part 2 and lower end 3, the top of upper end 1
The bottom end of end and lower end 3 is respectively formed upper port and lower port, and the internal diameter (interior diameter) of upper port and lower port is all greater than
The internal diameter (interior diameter) at the middle part 2.To realize radial support effect, expand its both ends, upper and lower end is in loudspeaker
Mouth shape is changeover portion between middle part 2 and upper and lower port.
The rack body passes through weaving by the PCL multifilament looping PPDO monofilament of load medicine (Rabdosia rubescens active constituent KY3)
Means building.There is negative poisson's ratio in the middle part of the rack body.The upper port of the rack body and the section of lower port
Concordantly, the internal diameter (interior diameter) of upper port and lower port is 22mm.Food meatus stent length is adjusted according to affected part in 40-80mm
Between, in addition to that cannot use at the food meatus tumour of throat, remaining position be can be used.
The preparation method of the degradable esophagus pipe holder of the antiskid self expandable of above-mentioned negative poisson's ratio structure, specific steps
Are as follows:
Step 1: using the middle part of Three-dimensional warp knitting interval needle technology braided support main body, middle part is by negative poisson's ratio structure list
The PCL multifilament looping PPDO monofilament straight pipe for the load medicine (Rabdosia rubescens active constituent KY3) that member 21 is constituted, straight pipe interior diameter
17mm, length are preferably 60mm, are woven using Three-dimensional warp knitting interval needle technology, pay attention to respectively retaining the free yarn of 140mm at both ends
Section, the reserved material as upper and lower ends braiding.During the braiding of the step 1, positive and negative coil successively horizontal sawtooth shape
Arrangement forms the tubular structure with negative poisson's ratio.As shown in Fig. 2, the structural unit 21 is by positive coil 11, reverse line
Successively horizontal sawtooth shape arranges and connects formation in tie point 13 circle 12, and rack body has negative poisson's ratio in the axial direction.
Step 2: after completing middle part weaving, the form for maintaining the middle part of rack body is supportted with ring steel, using annular weaving
Machine weaves upper and lower end (not having above structure unit 21) on the PE cylindrical body that diameter is 22mm.The bracket
Upper end, lower end and the central integration of main body;The changeover portion projected length between middle part and upper and lower port is kept to exist
5mm ± 0.03mm can adjust the length of upper and lower end by adjusting ring steel support and PE cylindrical body spacing.Above and below
The length of end is preferably 10mm.
Step 3: using the structure of thermal finalization processing center rest, heat setting temperature is 90 DEG C, and the time is 1 hour, is obtained
The degradable esophagus pipe holder of the antiskid self expandable of negative poisson's ratio structure.
The present invention is in use, by narrow section in food meatus stenter to implant food meatus, the upper/lower terminal portion of esophagus pipe holder
Narrow section both ends are located at, the process to implant can suitably be compressed, and place affected part and finish, the self-expanding of itself can support
Stenosis is played, so that patient can normally feed digestion, the compatibility of the good radial support power of bracket and good biology is convenient for
Close to attach esophageal wall, simultaneously because the design of negative poisson's ratio structure, in swallowing activity, esophageal peristalsis drives and moves past under food
Journey, cradle wall axially loaded, order drop-down at the point of contact of positive and negative coil in structural unit, bracket ring-type perimeter increases, section
Area increases, and radial expansion force causes bracket that can more attach esophageal wall.Significantly reduce shipper pole under esophageal peristalsis and food
A possibility that stent migration come.
According to above-described embodiment, the present invention can be realized well.Be worth explanation when based on the more of negative poisson's ratio structure
Sample, the implementation of similar structures can all come therefrom.
Embodiment 3
As shown in Figure 1, the degradable esophagus pipe holder of the antiskid self expandable of the negative poisson's ratio structure of the present embodiment includes pipe
The rack body of shape, the rack body include sequentially connected upper end 1, middle part 2 and lower end 3, the top of upper end 1
The bottom end of end and lower end 3 is respectively formed upper port and lower port, and the internal diameter (interior diameter) of upper port and lower port is all greater than
The internal diameter (interior diameter) at the middle part 2.To realize radial support effect, expand its both ends, upper and lower end is in loudspeaker
Mouth shape is changeover portion between middle part 2 and upper and lower port.
The rack body passes through weaving by the PCL multifilament looping PPDO monofilament of load medicine (Rabdosia rubescens active constituent KY3)
Means building.There is negative poisson's ratio in the middle part of the rack body.The upper port of the rack body and the section of lower port
Concordantly, the internal diameter (interior diameter) of upper port and lower port is 24mm.Food meatus stent length is adjusted according to affected part in 40-80mm
Between, in addition to that cannot use at the food meatus tumour of throat, remaining position be can be used.
Step 1: using the middle part of Three-dimensional warp knitting interval needle technology braided support main body, middle part is the structure by negative poisson's ratio
The PCL multifilament looping PPDO monofilament straight pipe for the load medicine (Rabdosia rubescens active constituent KY3) that unit 21 is constituted, straight pipe interior diameter
18mm, length are preferably 50mm, are woven using Three-dimensional warp knitting interval needle technology, pay attention to respectively retaining the free yarn of 120mm at both ends
Section, the reserved material as upper and lower ends braiding.During the braiding of the step 1, positive and negative coil successively horizontal sawtooth shape
Arrangement forms the tubular structure with negative poisson's ratio.As shown in Fig. 2, the structural unit 21 is by positive coil 11, reverse line
Successively horizontal sawtooth shape arranges and connects formation in tie point 13 circle 12, and rack body has negative poisson's ratio in the axial direction.
Step 2: after completing middle part weaving, the form for maintaining the middle part of rack body is supportted with ring steel, using annular weaving
Machine weaves upper and lower end (not having above structure unit 21) on the PE cylindrical body that diameter is 24mm.The bracket
Upper end, lower end and the central integration of main body;The changeover portion projected length between middle part and upper and lower port is kept to exist
5mm ± 0.03mm can adjust the length of upper and lower end by adjusting ring steel support and PE cylindrical body spacing.Above and below
The length of end is preferably 10mm.
Step 3: the structure of center rest in the way of thermal finalization, heat setting temperature are 90 DEG C, and the time is 1 hour, are obtained
To the degradable esophagus pipe holder of antiskid self expandable of negative poisson's ratio structure.
The present invention is in use, by narrow section in food meatus stenter to implant food meatus, the upper/lower terminal portion of esophagus pipe holder
Narrow section both ends are located at, the process to implant can suitably be compressed, and place affected part and finish, the self-expanding of itself can support
Stenosis is played, so that patient can normally feed digestion, the compatibility of the good radial support power of bracket and good biology is convenient for
Close to attach esophageal wall, simultaneously because the design of negative poisson's ratio structure, in swallowing activity, esophageal peristalsis drives and moves past under food
Journey, cradle wall axially loaded, order drop-down at the point of contact of positive and negative coil in structural unit, bracket ring-type perimeter increases, section
Area increases, and radial expansion force causes bracket that can more attach esophageal wall.Significantly reduce shipper pole under esophageal peristalsis and food
A possibility that stent migration come.
According to above-described embodiment, the present invention can be realized well.Be worth explanation when based on the more of negative poisson's ratio structure
Sample, the implementation of similar structures can all come therefrom.
Claims (10)
1. a kind of degradable esophagus pipe holder of the antiskid self expandable of negative poisson's ratio structure, which is characterized in that including by all or
Rack body made of the degradable material in part, the rack body include sequentially connected upper end, middle part and under
End, the top of upper end and the bottom end of lower end are respectively formed upper port and lower port, the internal diameter of upper port and lower port
All it is greater than the internal diameter at the middle part.
2. the degradable esophagus pipe holder of the antiskid self expandable of negative poisson's ratio structure as described in claim 1, which is characterized in that
The middle part of the rack body or all with negative poisson's ratio.
3. the degradable esophagus pipe holder of the antiskid self expandable of negative poisson's ratio structure as described in claim 1, which is characterized in that
The rack body is tubular structure.
4. the degradable esophagus pipe holder of the antiskid self expandable of negative poisson's ratio structure as described in claim 1, which is characterized in that
The upper and lower end is in the shape of a trumpet.
5. the degradable esophagus pipe holder of the antiskid self expandable of negative poisson's ratio structure as described in claim 1, which is characterized in that
The total length of the rack body is 40~80mm, and the internal diameter at the middle part of the rack body is 16~18mm, upper port
Concordant with the section of lower port, the internal diameter of upper port and lower port is 20~24mm.
6. the degradable esophagus pipe holder of the antiskid self expandable of negative poisson's ratio structure as described in claim 1, which is characterized in that
The middle part of the rack body is all made of the structural unit with negative poisson's ratio.
7. the degradable esophagus pipe holder of the antiskid self expandable of negative poisson's ratio structure as described in claim 1, which is characterized in that
Contain developer, drug or radioactive particle in the material of the rack body.
8. the system of the degradable esophagus pipe holder of the antiskid self expandable of negative poisson's ratio structure of any of claims 1-7
Preparation Method characterized by comprising
Step 1: using the middle part of Three-dimensional warp knitting interval needle technology braided support main body;
Step 2: supportting the form for maintaining the middle part of rack body with ring steel, be woven on PE cylindrical body and compiled using circular knitting machine
Knit upper and lower end, wherein upper end, lower end and the central integration of the rack body;
Step 3: carrying out thermal finalization processing, obtain the degradable esophagus pipe holder of antiskid self expandable of negative poisson's ratio structure.
9. the preparation method of the degradable esophagus pipe holder of the antiskid self expandable of negative poisson's ratio structure as claimed in claim 8,
It is characterized in that, adjusting upper and lower end by adjusting ring steel support with PE cylindrical body spacing in the step 2
Length.
10. the preparation method of the degradable esophagus pipe holder of the antiskid self expandable of negative poisson's ratio structure as claimed in claim 8,
It is characterized in that, successively horizontal sawtooth shape arranges to be formed with negative poisson's ratio positive and negative coil during the braiding of the step 1
Tubular structure.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910162678.2A CN109893309B (en) | 2019-03-05 | 2019-03-05 | Anti-slip self-expanding degradable esophageal tube support with negative Poisson ratio structure and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910162678.2A CN109893309B (en) | 2019-03-05 | 2019-03-05 | Anti-slip self-expanding degradable esophageal tube support with negative Poisson ratio structure and preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109893309A true CN109893309A (en) | 2019-06-18 |
CN109893309B CN109893309B (en) | 2021-06-18 |
Family
ID=66946402
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910162678.2A Active CN109893309B (en) | 2019-03-05 | 2019-03-05 | Anti-slip self-expanding degradable esophageal tube support with negative Poisson ratio structure and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109893309B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111544170A (en) * | 2020-05-13 | 2020-08-18 | 东华大学 | Anti-slip narrow-resistance esophageal stent with mesoporous structure |
CN113679936A (en) * | 2021-10-27 | 2021-11-23 | 上海微创医疗器械(集团)有限公司 | Degradable drug stent system and intranasal drug stent |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1586655A (en) * | 2004-07-02 | 2005-03-02 | 清华大学 | Method for preparing multilayer medicine composite degradable biliary tract rack visible under X-ray |
CN101513367A (en) * | 2009-04-02 | 2009-08-26 | 中国人民解放军总医院第二附属医院 | Degradable esophagus tubular intervention support and preparation method thereof |
CN102335052A (en) * | 2011-07-15 | 2012-02-01 | 南京微创医学科技有限公司 | Anti-restenosis digestive tract stent |
CN106236338A (en) * | 2016-09-27 | 2016-12-21 | 吉林大学 | Negative poisson's ratio degradable shape-memory polymer intravascular stent increases material manufacture method |
CN108309522A (en) * | 2018-02-10 | 2018-07-24 | 青岛大学 | A kind of biodegradable anti-displacement Esophageal Stent and preparation method |
-
2019
- 2019-03-05 CN CN201910162678.2A patent/CN109893309B/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1586655A (en) * | 2004-07-02 | 2005-03-02 | 清华大学 | Method for preparing multilayer medicine composite degradable biliary tract rack visible under X-ray |
CN101513367A (en) * | 2009-04-02 | 2009-08-26 | 中国人民解放军总医院第二附属医院 | Degradable esophagus tubular intervention support and preparation method thereof |
CN102335052A (en) * | 2011-07-15 | 2012-02-01 | 南京微创医学科技有限公司 | Anti-restenosis digestive tract stent |
CN106236338A (en) * | 2016-09-27 | 2016-12-21 | 吉林大学 | Negative poisson's ratio degradable shape-memory polymer intravascular stent increases material manufacture method |
CN108309522A (en) * | 2018-02-10 | 2018-07-24 | 青岛大学 | A kind of biodegradable anti-displacement Esophageal Stent and preparation method |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111544170A (en) * | 2020-05-13 | 2020-08-18 | 东华大学 | Anti-slip narrow-resistance esophageal stent with mesoporous structure |
CN111544170B (en) * | 2020-05-13 | 2021-12-10 | 东华大学 | Anti-slip narrow-resistance esophageal stent with mesoporous structure |
CN113679936A (en) * | 2021-10-27 | 2021-11-23 | 上海微创医疗器械(集团)有限公司 | Degradable drug stent system and intranasal drug stent |
Also Published As
Publication number | Publication date |
---|---|
CN109893309B (en) | 2021-06-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2961287B2 (en) | Biological duct dilator, method for producing the same, and stent | |
US6613077B2 (en) | Stent with controlled expansion | |
JP4469816B2 (en) | Moldable implant material and use thereof | |
US11969337B2 (en) | In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material | |
US20120116492A1 (en) | Medical device | |
JPH11188109A (en) | Bioabsorptive inplantable artificial organ having reservoir and its use method | |
CN109893309A (en) | The degradable esophagus pipe holder of the antiskid self expandable of negative poisson's ratio structure and its preparation | |
CN108066048B (en) | It is thermally bonded degradable intraluminal stent of composite construction and its preparation method and application | |
Wang et al. | In vitro degradation behaviours of PDO monofilament and its intravascular stents with braided structure | |
CN104382671A (en) | Degradable human body stent capable of effectively preventing transposition and reducing hyperplasia and manufacturing method | |
JP2008253297A (en) | Medical tube | |
CN108025108A (en) | A kind of individual polymer stent and its preparation method and application | |
US11883275B2 (en) | In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material | |
US20230248551A1 (en) | Coated stent | |
Fukunishi et al. | Formation of neoarteries with optimal remodeling using rapidly degrading textile vascular grafts | |
Feng et al. | Intestinal stents: Structure, functionalization and advanced engineering innovation | |
CN204169954U (en) | A kind of degradable human body alimentary canal support that effectively can prevent displacement, reduce hypertrophy | |
JPH01277567A (en) | Prosthetic product | |
JP2018175776A (en) | Covered stent | |
CN108309522B (en) | A kind of biodegradable anti-displacement Esophageal Stent and preparation method | |
CN210990958U (en) | Layered degradable polymer stent | |
JP2008011942A (en) | Medical tube | |
JP2004033579A (en) | Biological absorptive stent and manufacturing method for the same | |
CN113101022A (en) | Preparation method of specific in-vivo lumen implant | |
EP3677227B1 (en) | Stent and medical device comprising same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |