CN109893304B

CN109893304B - 3D of specific form and structure prints tissue engineering support

Info

Publication number: CN109893304B
Application number: CN201910302496.0A
Authority: CN
Inventors: 曹博强; 贺镜羽; 汪漫; 牛丽文; 金利玉; 李洪兵
Original assignee: Sir Run Run Hospital Nanjing Medical University
Current assignee: Sir Run Run Hospital Nanjing Medical University
Priority date: 2019-04-16
Filing date: 2019-04-16
Publication date: 2021-03-23
Anticipated expiration: 2039-04-16
Also published as: CN109893304A

Abstract

The invention relates to the technical field of human body bioengineering, in particular to a 3D printing tissue engineering scaffold with a specific shape and structure, which comprises a structural body, wherein the structural body is composed of a plurality of groups of parallel net strips with different directions among each group, and reinforcing ribs for interweaving and connecting the net strips are arranged among the net strips. According to the invention, the mesh strips are connected through the reinforcing ribs distributed at intervals, the physiological shape model is formed in a macroscopic form, the auricle bracket is manufactured by adopting a 3D printing titanium alloy method, the preparation is made for improving the conventional auricle reconstruction operation for the small ear malformation, the trouble of cutting costal cartilage through chest operation is eliminated, the pain of a patient is relieved, the complicated steps for manufacturing the auricle bracket are simplified, the workload and the working strength of doctors are relieved, the operation difficulty is reduced, the operation time is shortened, the occurrence possibility of complications is reduced, more operation modes are provided for the patient and family members thereof, and the mesh-type surgical bracket has good application prospect and market demand.

Description

3D of specific form and structure prints tissue engineering support

Technical Field

The invention relates to the technical field of human body bioengineering, in particular to a 3D printing tissue engineering scaffold with a specific shape and structure.

Background

The treatment of congenital microtia is based on a reconstruction of the external ear pinna. The normal auricle is formed by wrapping an elastic cartilage support by thin and thin skin soft tissue, has an elastic thin shell structure, and consists of an helix, an antihelix, an tragus, an antitragus, an earlobe, an concha, a triangular fossa, a navicular fossa and the like, and is in convex-concave convolution and complex shape, so the auricle reconstruction is a difficult and complex operation. The operation modes mainly applied in clinic at present are mainly divided into two major types, one type is dilator method ear reconstruction, including a half-wrapping method and a full-wrapping method, and the other type is non-dilator method, including Brent-Nagata method (also called direct burial method) and one-time forming method. In any method, part of costal cartilage of a patient needs to be cut and spliced and carved to be made into an auricle shape, and auricle reconstruction is performed in stages.

Although the auricle reconstruction can create a reconstructed ear which is very similar to the normal auricle shape, the factors influencing the reconstructed ear shape are many, and the residual ear and the skin behind the residual ear have elasticity, thickness, size and the like which all influence the operation effect; meanwhile, the costal cartilage itself has a large wound on a patient, and the costal cartilage is left to be lost after operation, so that inconvenience is inevitably caused to future life; in addition, as a difficulty of the operation, the length, shape and thickness of the cut costal cartilage are greatly different, and the carving treatment of the costal cartilage is a great challenge to the aesthetic quality and the skill of the operating physician. Therefore, the operation has the characteristics of high operation difficulty, long operation time, loss of a plurality of costal cartilages after the operation and the like. In view of this, we propose a 3D printed tissue engineering scaffold of a specific morphology and structure.

Disclosure of Invention

The invention aims to provide a specific form and structure of a 3D printing tissue engineering scaffold, and aims to solve the problems of high difficulty, long time and rib cartilage loss of a patient in the conventional auricle reconstruction operation in the background art.

In order to achieve the purpose, the invention provides the following technical scheme:

the utility model provides a 3D of specific form and structure prints tissue engineering support, includes structure body (1), its characterized in that: the structural body (1) is composed of a plurality of groups of parallel net strips, the mutual directions of each group of net strips are different, and reinforcing structures for interweaving the net strips are arranged between different groups of net strips.

The structure body (1) is usually composed of a plurality of groups of parallel net strips, and generally comprises a transverse net strip (11) and a longitudinal net strip (12), a plurality of reinforcing rib structures are arranged on the structure body (1), usually, four ribs form a diamond grid (2) as a reinforcing structure, the diamond grid (2) is composed of a plurality of connecting strips (20), and the connecting strips (20) are sequentially connected and formed through a front fulcrum (201), a left fulcrum (203), a rear fulcrum (202) and a right fulcrum (204).

The transverse net strips (11) are formed by net strips which are transverse and basically parallel to each other, the longitudinal net strips (12) are formed by net strips which are longitudinal and basically parallel to each other, the transverse net strips (11) are perpendicular to the longitudinal net strips (12), the transverse net strips (11) are not in contact with the longitudinal net strips (12), the transverse net strips and the longitudinal net strips are staggered with each other, and the transverse net strips and the longitudinal net strips are in a weaving shape.

The transverse net strips (11) are in a sawtooth shape or a chord wave shape.

The longitudinal net strips (12) are in a sawtooth shape or a chord wave shape, and the longitudinal net strips (12) and the transverse net strips (11) have basically the same structure.

The rhombic reinforcing structures (2) are positioned in the grid units (10), the rhombic grids (2) are distributed in a matrix mode, and one or more grid units (10) can be arranged between every two adjacent rhombic grids (2).

The front fulcrum (201) and the rear fulcrum (202) are respectively located on two adjacent transverse net strips (11), and the left fulcrum (203) and the right fulcrum (204) are respectively located on two adjacent longitudinal net strips (12).

The rhombus grids (2) and the structural body (1) are of an integrally formed structure.

Compared with the prior art, the invention has the beneficial effects that: according to the invention, a plurality of groups of net strips which are in different directions and are not in contact with each other are connected through a plurality of reinforcing structures which are distributed at intervals to form a model with a specific shape, and the auricle bracket is manufactured by adopting a 3D printing titanium alloy method, so that the preparation is made for improving the conventional auricle reconstruction operation for the small ear malformation, the trouble of cutting costal cartilage through chest surgery is eliminated, the pain of a patient is relieved, the complicated steps for manufacturing the auricle bracket are simplified, the workload and the working strength of doctors are relieved, the operation difficulty is reduced, the operation time is shortened, the occurrence possibility of complications is reduced, more operation modes are provided for the patient and family members of the patient, and the application prospect and the market demand are good.

Drawings

FIG. 1 is a schematic front view of a 3D printed tissue engineering scaffold according to certain aspects and structures of the present invention;

FIG. 2 is a schematic view of the backside structure of the present invention;

FIG. 3 is a left side view of the structural body (partial) of the present invention;

fig. 4 is a schematic top view of the structural body (partial) of the present invention.

In the figure: 1. a structural body; 10. a grid; 11. transverse net strips; 12. longitudinal net strips; 2. a diamond grid; 20. a connecting strip; 201. a front fulcrum; 202. a rear fulcrum; 203. a left fulcrum; 204. and (4) a right fulcrum.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it is to be understood that the terms "longitudinal", "lateral", "front", "rear", "left", "right", and the like, indicate orientations or positional relationships based on those shown in the drawings, are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.

Further, in the description of the present invention, "a number" means at least two, e.g., two, three, etc., unless specifically limited otherwise.

Referring to fig. 1-4, the present invention provides a technical solution:

the utility model provides a 3D of specific form and structure prints tissue engineering support, includes structure body 1, and structure body 1 comprises a plurality of vertical nettings 12 and a plurality of vertical nettings 12, and a plurality of vertical nettings 12 constitute a plurality of net 10, and the rule is equipped with a plurality of rhombus check 2 on the structure body 1, and rhombus check 2 comprises four connecting strip 20, and four connecting strip 20 loop through left fulcrum 203, right fulcrum 204 and right fulcrum 204 connection shaping.

In this embodiment, the plurality of longitudinal net strips 12 are parallel to each other, so that two adjacent longitudinal net strips 12 are not in contact with each other; furthermore, the longitudinal net strips 12 are parallel to each other, so that two adjacent longitudinal net strips 12 are not contacted with each other; the longitudinal net strips 12 are perpendicular to the longitudinal net strips 12, and the longitudinal net strips 12 are not in contact with the longitudinal net strips 12, so that the structural body 1 has elasticity.

Further, the longitudinal wires 12 are serrated, which gives the longitudinal wires 12 elasticity.

Further, the longitudinal net strips 12 are in a sawtooth shape, the sawtooth structures of the longitudinal net strips 12 and the longitudinal net strips 12 are the same, so that the longitudinal net strips 12 have elasticity, and when the structural body 1 is under pressure, the deformation degrees of the longitudinal net strips 12 and the longitudinal net strips 12 are the same.

In this embodiment, the diamond lattices 2 are located in the grid 10, the plurality of diamond lattices 2 are distributed in a matrix, one grid 10 is arranged between every two adjacent diamond lattices 2, the structural body 1 is formed into a three-dimensional shape by the diamond lattices 2 distributed at intervals, and when the structural body 1 is made of a hard material, the structural body can also have good elasticity.

In this embodiment, the left fulcrum 203 and the right fulcrum 204 are respectively located on two adjacent longitudinal mesh strips 12, and the left fulcrum 203 and the right fulcrum 204 are respectively located on two adjacent longitudinal mesh strips 12.

Further, only a plurality of left supporting points 203 exist on one longitudinal net strip 12, only a plurality of right supporting points 204 exist on the adjacent longitudinal net strip 12, and specifically, the longitudinal net strip 12 with the left supporting points 203 and the longitudinal net strip 12 with the right supporting points 204 are sequentially distributed in a staggered manner.

Specifically, only a plurality of left supporting points 203 exist on one longitudinal net strip 12, only a plurality of right supporting points 204 exist on the adjacent longitudinal net strip 12, and specifically, the longitudinal net strips 12 with the left supporting points 203 and the longitudinal net strips 12 with the right supporting points 204 are sequentially distributed in a staggered manner, so that the diamond lattices 2 can be distributed at intervals.

In this embodiment, rhombus check 2 is the integrated into one piece structure with structure body 1, specifically, structure body 1 prints the titanium alloy material through the mode of 3D printing and makes, easy operation is swift.

Specifically, the shape of the structural body 1 can be modeled and customized according to the use requirement, the model can be an external auricle, an external nose, a nasal prosthesis, a jaw prosthesis, and the like, and the shape of the structural body 1 in this embodiment is preferably the shape of a small ear cartilage scaffold.

Furthermore, the small ear support can be partitioned according to the requirements of the used strength and elasticity in the modeling process, and different strengths and elasticity are realized by adjusting the shape, density, distribution and structure of the net shape in different areas of the support model, so that the artificial small ear support made of hard materials has the elasticity and texture similar to that of a real small ear support, and the attractiveness of the artificial auricle is improved.

Furthermore, the support is composed of a plurality of groups of parallel net strips, the mutual directions of each group of net strips are different, and the most basic two groups of net strips are respectively horizontal and longitudinal and are arranged according to the requirement of structural strength. The reinforcing structure is set according to the structural strength, for example theoretically, carry out finite element analysis to the model before carrying out 3D printing, and then obtain the evaluation result, later decide as required in what position to consolidate. When the 3D printing tissue engineering scaffold with a specific form and structure is used, a specific tissue structure shape, namely a cartilage scaffold of an outer auricle, is scanned by using CT, an image obtained by CT scanning is converted into a digital model, the digital model adopts a grid structure of a structure body 1, different regions of the model are adjusted in shape, density and the like according to the structure of a normal auricle, after the shape and the size of the model are determined, a powdery titanium alloy material is added into a 3D printer, and the constructed small auricle scaffold model is printed into a solid scaffold.

The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and the preferred embodiments of the present invention are described in the above embodiments and the description, and are not intended to limit the present invention. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims

1. The utility model provides a 3D of specific form and structure prints tissue engineering support, includes structure body (1), its characterized in that: the structural body (1) is composed of a transverse net building strip and a longitudinal net building strip, and a reinforcing structure for interweaving the transverse net building strip and the longitudinal net building strip is arranged between the transverse net building strip and the longitudinal net building strip; the diamond grid (2) is used as a reinforcing structure, the diamond grid (2) is composed of four connecting strips (20), and the four connecting strips (20) are connected and formed sequentially through a front fulcrum (201), a left fulcrum (203), a rear fulcrum (202) and a right fulcrum (204); the transverse net forming strips (11) are formed by net strips which are transverse and basically parallel to each other, the longitudinal net forming strips (12) are formed by net strips which are longitudinal and basically parallel to each other, the transverse net forming strips (11) are perpendicular to the longitudinal net forming strips (12), the transverse net forming strips (11) are not in contact with the longitudinal net forming strips (12), the transverse net forming strips and the longitudinal net forming strips are staggered with each other, and a grid unit is formed; the transverse net assembling strips (11) are in a sawtooth shape or a chord wave shape; the longitudinal net forming strips (12) are in a sawtooth shape or a chord wave shape, and the structures of the longitudinal net forming strips (12) and the transverse net forming strips (11) are basically the same; the rhombic grids (2) are positioned in the grid units (10), a plurality of rhombic grids (2) are distributed in a matrix manner, and one or more grid units (10) are arranged between every two adjacent rhombic grids (2); the front fulcrum (201) and the rear fulcrum (202) are respectively positioned on two adjacent transverse netting strips (11), and the left fulcrum (203) and the right fulcrum (204) are respectively positioned on two adjacent longitudinal netting strips (12); the rhombus grids (2) and the structural body (1) are of an integrally formed structure.