CN109893304A - A kind of 3D printing tissue engineering bracket of specific modality and structure - Google Patents
A kind of 3D printing tissue engineering bracket of specific modality and structure Download PDFInfo
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- CN109893304A CN109893304A CN201910302496.0A CN201910302496A CN109893304A CN 109893304 A CN109893304 A CN 109893304A CN 201910302496 A CN201910302496 A CN 201910302496A CN 109893304 A CN109893304 A CN 109893304A
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Abstract
The present invention relates to human-body biological field of engineering technology, the 3D printing tissue engineering bracket of in particular a kind of specific modality and structure, including structural body ontology, structural body ontology is made of the different parallel net item in direction between multiple groups and every group, is equipped between net item by the reinforcement rib of their intertexture connections.The present invention is connected several net items by several reinforcement ribs being spaced apart, the model of its macroscopic form composition physiology shape, Auricular framework is made using the method for 3D printing titanium alloy, it prepares to improve auricle reconstruction surgery outside currently used microtia, eliminate the trouble that costal cartilage is intercepted by thoracic operation, alleviate the pain of patient, simplify the tedious steps of Auricular framework production, alleviate the workload and working strength of doctor, reduce operating difficulty, shorten operating time, reduce the possibility occurrence of complication, the selection of more modus operandis is provided for patient and its family members, it has a good application prospect and the market demand.
Description
Technical field
The present invention relates to human-body biological field of engineering technology, the 3D printing group weaver of specially a kind of specific modality and structure
Engineering support.
Background technique
The basis of the treatment of congenital microtia is outer total auricular reconstruction.Normal auricle is by thin thin skin soft tissue packet
It wraps up in composed by elastic cartilage bracket, flexible shell structure, and by helix, anthelix, tragus, antitragus, ear-lobe, ear
First, fossa triangularis, navicula etc. are constituted, convex-concave convolution, complex shape, therefore total auricular reconstruction is a difficulty, complicated operation.Mesh
Preceding clinical main modus operandi to be applied is broadly divided into two major classes, and one kind is expander method ear reconstruction, including half bag method and complete
Bag method, another kind of is on-expansible method, including Brent-Nagata method (also known as method of directly burring), once moulding method.No matter which kind of method,
It requires interception patient part's costal cartilage to splice, carve, is fabricated to auricle form, by stages row reconstruction of auricle.
Although row reconstruction of auricle can produce the reconstruction ear closely similar with normal auricle shape state, reconstruction ear shape is influenced
There are many factor of state, the elastic of skin, thickness, size etc. after residual ear and residual ear, these conditions can all influence the effect of operation；Together
When, take costal cartilage itself to have compared with major trauma patient, it is postoperative to leave costal cartilage missing, inevitably bring inconvenience to later life；This
Outside, as the difficult point of the operation, the engraving processing of costal cartilage all very big with the length, shape, thickness difference of costal cartilage is cut,
Even more to the aesthetic of surgical doctor and with the great challenge of knife skill.Therefore, which has operating difficulty height, operating time
It is long, postoperative the features such as causing more costal cartilage missings.In consideration of it, it is proposed that a kind of 3D printing tissue of specific modality and structure
Engineering rack.
Summary of the invention
The purpose of the present invention is to provide a kind of specific modality and structure, the purpose of the present invention is to provide a kind of specific shapes
The 3D printing tissue engineering bracket of state and structure, to solve to propose existing auricle reconstruction surgery difficulty in above-mentioned background technique
The problem of high, time is long and patient's costal cartilage is caused to lack.
To achieve the above object, the invention provides the following technical scheme:
A kind of 3D printing tissue engineering bracket of specific modality and structure, including structural body ontology (1), it is characterised in that:
The structural body ontology (1) is made of the parallel net item of multiple groups, and mutual direction is different between every networking item, the net items of difference group it
Between be equipped with they interweave the reinforcement structure of connection.
The structural body ontology (1) is usually made of the parallel net item of multiple groups, is generally divided into lateral networking item (11) and is indulged
To networking item (12), the structural body ontology (1) is equipped with several reinforcement rib structures, and usual four ribs constitute diamond-plaid (2) and make
For reinforcement structure, diamond-plaid (2) You Duogen connection strap (20) composition, four connection straps (20) pass sequentially through front fulcrum
(201), Zuo Zhidian (203), rear fulcrum (202) and right fulcrum (204) connection molding.
The transverse direction net item (11) by being all transverse direction and the net item that is substantially parallel to one another is constituted, the longitudinal network item (12) by
It is all longitudinal direction and the net item composition being substantially parallel to one another, the transverse direction net item (11) and the longitudinal network item (12) are orthogonal,
And the lateral net item (11) and the longitudinal network item (12) are not in contact with each other, and interlaced, are in braided.
The transverse direction net item (11) is serrated or string is wavy.
The longitudinal network item (12) is serrated or string is wavy, the longitudinal network item (12) and the lateral net item (11)
Structure it is essentially identical.
The diamond shape reinforcement structure (2) is located in grid cell (10), and several diamond-plaids (2) are distributed in matrix, often
One or more grid cells (10) can be separated between two adjacent diamond-plaids (2).
The front fulcrum (201) and the rear fulcrum (202) are located on the lateral net item (11) of adjacent two, described
Left fulcrum (203) and the right fulcrum (204) are located on two adjacent longitudinal network items (12).
The diamond-plaid (2) is an integral molding structure with the structural body ontology (1).
Compared with prior art, the beneficial effects of the present invention are: the present invention will by several reinforcement structures being spaced apart
Multiple groups different directions and between each other non-touching net item connect, the model of specific shape is formed, using 3D printing titanium
The method of alloy makes Auricular framework, prepares, eliminates logical to improve auricle reconstruction surgery outside currently used microtia
The trouble for crossing thoracic operation interception costal cartilage, alleviates the pain of patient, simplifies the tedious steps of Auricular framework production, mitigates
The workload and working strength of doctor, reduces operating difficulty, shortens operating time, and the generation for reducing complication may
Property, provides the selection of more modus operandis for patient and its family members, has a good application prospect and the market demand.
Detailed description of the invention
Fig. 1 is the positive structure schematic of the 3D printing tissue engineering bracket of specific modality of the present invention and structure；
Fig. 2 is structure schematic diagram of the invention；
Fig. 3 is the left view structural representation of structural body ontology (part) of the invention；
Fig. 4 is the overlooking structure diagram of structural body ontology (part) of the invention.
In figure: 1, structural body ontology；10, grid；11, lateral net item；12, longitudinal network item；2, diamond-plaid；20, connection strap；
201, front fulcrum；202, rear fulcrum；203, Zuo Zhidian；204, right fulcrum.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that, term " longitudinal direction ", " transverse direction ", "front", "rear", "left", "right" etc.
The orientation or positional relationship of instruction is to be based on the orientation or positional relationship shown in the drawings, and is merely for convenience of the description present invention and letter
Change description, rather than the device or element of indication or suggestion meaning must have a particular orientation, with specific orientation construct and
Operation, therefore be not considered as limiting the invention.
In addition, in the description of the present invention, " several " are meant that at least two, such as two, three etc., unless otherwise
Clear specific restriction.
Fig. 1-4 is please referred to, the present invention provides a kind of technical solution:
A kind of 3D printing tissue engineering bracket of specific modality and structure, including structural body ontology 1, structural body ontology 1 by
Several longitudinal network items 12 and several longitudinal network items 12 composition, several longitudinal network items 12 and several longitudinal network items 12 constitute several grids
10, rule is equipped with several diamond-plaids 2 on structural body ontology 1, and diamond-plaid 2 is made of four connection straps 20, four connection straps 20 according to
Secondary connected by left fulcrum 203, Zuo Zhidian 203, right fulcrum 204 and right fulcrum 204 forms.
In the present embodiment, several longitudinal network items 12 are parallel to each other, and two adjacent longitudinal network items 12 is made to be not in contact with each other；Into one
Step ground, several longitudinal network items 12 are parallel to each other, and two adjacent longitudinal network items 12 is made to be not in contact with each other；Longitudinal network item 12 and longitudinal network
Item 12 is orthogonal, and longitudinal network item 12 and longitudinal network item 12 are not in contact with each other, and structural body ontology 1 is made to have elasticity.
Further, longitudinal network item 12 is serrated, and longitudinal network item 12 is made to have elasticity.
Further, longitudinal network item 12 is serrated, and longitudinal network item 12 is identical as the broached-tooth design of longitudinal network item 12, makes to indulge
There is elasticity to net item 12, and when structural body ontology 1 is under pressure, longitudinal network item 12 and the degree that deformation occurs of longitudinal network item 12
It is identical.
In the present embodiment, diamond-plaid 2 is located in grid 10, and several diamond-plaids 2 are distributed in matrix, every two adjacent diamond shape
It is separated with a grid 10 between lattice 2, so that structural body ontology 1 is constituted stereo structure by the diamond-plaid 2 being spaced apart, when structural body sheet
When body 1 is made of hard material, can also have good elasticity.
In the present embodiment, Zuo Zhidian 203 and right fulcrum 204 are located on two adjacent longitudinal network items 12, Zuo Zhidian
203 and right fulcrum 204 be located on two adjacent longitudinal network items 12.
Further, several left fulcrums 203 are only existed on a longitudinal network item 12, are only deposited on adjacent longitudinal network item 12
In several right fulcrums 204, specifically, longitudinal network item 12 with left fulcrum 203 and the longitudinal network item 12 with right fulcrum 204 according to
It is secondary to be interspersed.
Specifically, several left fulcrums 203 are only existed on a longitudinal network item 12, are only existed on adjacent longitudinal network item 12
Several right fulcrums 204, specifically, the longitudinal network item 12 with left fulcrum 203 and the longitudinal network item 12 with right fulcrum 204 are successively
It is interspersed, ensures that diamond-plaid 2 can be spaced apart with this.
In the present embodiment, diamond-plaid 2 is an integral molding structure with structural body ontology 1, and specifically, structural body ontology 1 passes through
Titanium alloy material printing is made the mode of 3D printing, simple and quick.
Specifically, the shape of structural body ontology 1 can carry out modeling customization according to use demand, and model can be external ear
Exterior feature, external nose, ose implant and jaw prosthese etc., structural body ontology 1 is preferably shaped to small ear cartilage frame in the present embodiment
Shape.
Further, can be divided according to the demand of the intensity and elasticity that use to small ear support in modeling process
Area realizes different intensity in the different zones of stent model by adjusting netted shape, density, distribution and structure
And elasticity, so that artificial small ear support made of hard material be made to have and elasticity and matter similar in genuine small ear support
Sense improves the aesthetics of artificial outer auricle.
Further, this bracket is made of the parallel net item of multiple groups, and mutual direction is different between every networking item, most basic
For two networking items, it is lateral, longitudinal direction respectively, is configured according to the needs of structural strength.Reinforcement structure is set according to structural strength
It sets, such as theoretically, finite element analysis is carried out to model before carrying out 3D printing, and then obtain assessment result, later as needed
Determine where reinforced.The 3D printing tissue engineering bracket of the specific modality of the present embodiment and structure when in use,
Go out specific tissue structure shape, i.e., the cartilage frame of outer auricle with CT scan first, and the image that CT scan is obtained is converted
At mathematical model, and the mathematical model is using the network of structural body ontology 1, is according to right with the structure of normal auricle
The different zones of model carry out the adjustment of shape, density etc., after the shape and size for determining model, finally in 3D printer
It is interior that powdered titanium alloy material is added, the small ear stent model of building is printed as entity bracket.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
For personnel it should be appreciated that the present invention is not limited to the above embodiments, described in the above embodiment and specification is only the present invention
Preference, be not intended to limit the invention, without departing from the spirit and scope of the present invention, the present invention also has various
Changes and improvements, these changes and improvements all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by institute
Attached claims and its equivalent thereof.
Claims (6)
1. the 3D printing tissue engineering bracket of a kind of specific modality and structure, including structural body ontology (1), it is characterised in that: institute
It states structural body ontology (1) to be made of the parallel net item of multiple groups, mutual direction is different between every networking item, between the net item of difference group
Equipped with they are interweaved the reinforcement structure of connection；It is characterized by: the net item that the structural body ontology (1) is usually parallel by multiple groups
It constitutes, is generally divided into lateral networking item (11) and longitudinal networking item (12), the structural body ontology (1) is equipped with several reinforcement ribs
Structure, usual four ribs constitute diamond-plaid (2) and are used as reinforcement structure, and diamond-plaid (2) the You Duogen connection strap (20) forms, and four
Connection strap described in root (20) passes sequentially through front fulcrum (201), Zuo Zhidian (203), rear fulcrum (202) and right fulcrum (204) even
It is connected into type；It is characterized by: the transverse direction net item (11) is by being all transverse direction and the net item that is substantially parallel to one another is constituted, the longitudinal direction
Net item (12) is by being all longitudinal direction and the net item that is substantially parallel to one another is constituted, the transverse direction net item (11) and the longitudinal network item (12)
It is orthogonal, and the lateral net item (11) and the longitudinal network item (12) are not in contact with each other, and interlaced, are in braided.
2. the 3D printing tissue engineering bracket of specific modality according to claim 1 and structure, it is characterised in that: the cross
It is serrated to net item (11) or string is wavy.
3. the 3D printing tissue engineering bracket of specific modality according to claim 1 and structure, it is characterised in that: described vertical
It is serrated to net item (12) or string is wavy, the basic phase of structure of the longitudinal network item (12) and the lateral net item (11)
Together.
4. the 3D printing tissue engineering bracket of specific modality according to claim 1 and structure, it is characterised in that: the water chestnut
Shape reinforcement structure (2) is located in grid cell (10), and several diamond-plaids (2) are distributed in matrix, every two adjacent described
One or more grid cells (10) can be separated between diamond-plaid (2).
5. the 3D printing tissue engineering bracket of specific modality according to claim 1 and structure, it is characterised in that: before described
Fulcrum (201) and the rear fulcrum (202) are located on adjacent two lateral net items (11), the left fulcrum (203) and
The right fulcrum (204) is located on two adjacent longitudinal network items (12).
6. the 3D printing tissue engineering bracket of specific modality according to claim 1 and structure, it is characterised in that: the water chestnut
Shape lattice (2) are an integral molding structure with the structural body ontology (1).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910302496.0A CN109893304B (en) | 2019-04-16 | 2019-04-16 | 3D of specific form and structure prints tissue engineering support |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910302496.0A CN109893304B (en) | 2019-04-16 | 2019-04-16 | 3D of specific form and structure prints tissue engineering support |
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| CN109893304A true CN109893304A (en) | 2019-06-18 |
| CN109893304B CN109893304B (en) | 2021-03-23 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104383602A (en) * | 2011-12-26 | 2015-03-04 | 蔡淑芬 | Medical implant |
| CN108888386A (en) * | 2018-07-11 | 2018-11-27 | 西安增材制造国家研究院有限公司 | Porous ear supporter of local enhancement and preparation method thereof |
| CN108904880A (en) * | 2018-06-15 | 2018-11-30 | 南京市第医院 | A kind of 3D printing PCL-PDA-BMP2 bone tissue engineering scaffold and preparation method thereof |
| CN109172051A (en) * | 2018-10-16 | 2019-01-11 | 北京航空航天大学 | Novel energy-absorbing damping acetabular cup |
-
2019
- 2019-04-16 CN CN201910302496.0A patent/CN109893304B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104383602A (en) * | 2011-12-26 | 2015-03-04 | 蔡淑芬 | Medical implant |
| CN108904880A (en) * | 2018-06-15 | 2018-11-30 | 南京市第医院 | A kind of 3D printing PCL-PDA-BMP2 bone tissue engineering scaffold and preparation method thereof |
| CN108888386A (en) * | 2018-07-11 | 2018-11-27 | 西安增材制造国家研究院有限公司 | Porous ear supporter of local enhancement and preparation method thereof |
| CN109172051A (en) * | 2018-10-16 | 2019-01-11 | 北京航空航天大学 | Novel energy-absorbing damping acetabular cup |
Non-Patent Citations (1)
| Title |
|---|
| 常玉萍: ""负泊松比经编间隔织物制备与性能研究"", 《中国优秀硕士学位论文全文数据库 工程科技Ⅰ辑》 * |
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Denomination of invention: A 3D printing tissue engineering scaffold with specific shape and structure Effective date of registration: 20221209 Granted publication date: 20210323 Pledgee: China Merchants Bank Co.,Ltd. Nanjing Branch Pledgor: SIR RUN RUN HOSPITAL NANJING MEDICAL University Registration number: Y2022980026297 |
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