CN109875975A - A kind of natural vitamin E soft capsule preparation process - Google Patents

A kind of natural vitamin E soft capsule preparation process Download PDF

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Publication number
CN109875975A
CN109875975A CN201910263796.2A CN201910263796A CN109875975A CN 109875975 A CN109875975 A CN 109875975A CN 201910263796 A CN201910263796 A CN 201910263796A CN 109875975 A CN109875975 A CN 109875975A
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CN
China
Prior art keywords
preparation process
vitamin
soft capsule
sizing
glue
Prior art date
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Pending
Application number
CN201910263796.2A
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Chinese (zh)
Inventor
韦家华
刘玉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HAINAN HISHEN TONGZHOU PHARMACEUTICAL CO Ltd
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HAINAN HISHEN TONGZHOU PHARMACEUTICAL CO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by HAINAN HISHEN TONGZHOU PHARMACEUTICAL CO Ltd filed Critical HAINAN HISHEN TONGZHOU PHARMACEUTICAL CO Ltd
Priority to CN201910263796.2A priority Critical patent/CN109875975A/en
Publication of CN109875975A publication Critical patent/CN109875975A/en
Pending legal-status Critical Current

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  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses a kind of natural vitamin E soft capsule preparation process, the preparation process is as follows: raw material preparation, prepares, and changes glue, and pelleting, sizing are dry, pick ball, packaging;The beneficial effects of the present invention are: materials are few, the time-consuming of preparation is saved, improves the efficiency of preparation;Temperature control is good, high yield rate, increases curative effect of the natural vitamin E soft capsule in terms of Cardial or cerebral vascular diseases and habitual abortion, infertility.

Description

A kind of natural vitamin E soft capsule preparation process
Technical field
The invention belongs to vitamin E soft capsule preparation technical fields, and in particular to a kind of natural vitamin E soft capsule preparation Technique.
Background technique
Vitamin E soft capsule, indication are for Cardial or cerebral vascular diseases and habitual abortion, the adjuvant treatment of infertility.
There is the deficiencies of following aspect in existing natural vitamin E soft capsule preparation process:
1. preparation process is cumbersome, the time-consuming of preparation is increased;
2. the soft capsule of preparation is insufficient in terms of curative effect.
Summary of the invention
The purpose of the present invention is to provide a kind of natural vitamin E soft capsule preparation processes, to solve above-mentioned background technique The preparation process of middle proposition is cumbersome, increases the time-consuming of preparation;The soft capsule of preparation problem insufficient in terms of curative effect.
To achieve the above object, the invention provides the following technical scheme: a kind of natural vitamin E soft capsule preparation process, The preparation process is as follows:
Step 1: raw material preparation: natural type vitamin E, soybean oil, gelatinum pro capsulae, glycerol, ethyl hydroxy benzoate, purified water, Its composition by weight are as follows: natural type vitamin e1 00g, soybean oil 200g, gelatinum pro capsulae 260g, glycerol 90g, ethyl hydroxy benzoate 2g, purified water 250g;
Step 2: it prepares: being added in ingredients pot by recipe quantity weighing natural type vitamin E, soybean oil, after mixing evenly, Cross mesh, semi-finished product inspection;
Step 3: change glue: will be carried out in recipe quantity gelatinum pro capsulae, purified water, glycerol and ethyl hydroxy benzoate investmentization glue tank Colloidal sol vacuumizes;Glue is put in spare in insulation barrel by mesh;
Step 4: according to the detection level of semi-finished product, prepared natural type vitamin E medical fluid and glue pelleting, sizing: are taken Liquid carries out pelleting, regular check content uniformity, and adjusts in time, and the capsule and pill of extrusion is formed in sizing rotating cage, dry after sizing;
Step 5: dry: the good capsule and pill of pressed sizing is pulled to drying room and is dried, temperature control, controls relative humidity.
Step 6: ball, packaging are picked: carrying out picking ball after dry, rejects unqualified ball;The qualified ball picked is subjected to plastic-aluminum packet Dress, and product inspection is sampled, mounted box, vanning.
As a preferred technical solution of the invention, in the step 2, after mixing evenly, cross 200 meshes, half at Product inspection.
As a preferred technical solution of the invention, in the step 3, by recipe quantity gelatinum pro capsulae, purifying Temperature control is stirred 2 hours at 80~90 DEG C in water, glycerol and ethyl hydroxy benzoate investmentization glue tank, carries out colloidal sol.
As a preferred technical solution of the invention, in the step 3, glue is put in insulation barrel by 120 meshes Middle heat preservation 24 hours spare.
As a preferred technical solution of the invention, in the step 4, the capsule and pill of extrusion is default in sizing rotating cage It is type 2~3 hours, dry after sizing.
As a preferred technical solution of the invention, in the step 5,18 DEG C~26 DEG C of temperature control is relatively wet Degree≤26%.
Compared with prior art, the beneficial effects of the present invention are:
(1) materials are few, save the time-consuming of preparation, improve the efficiency of preparation;
(2) temperature control is good, high yield rate, increases natural vitamin E soft capsule in Cardial or cerebral vascular diseases and habitual stream It produces, the curative effect in terms of infertility.
Detailed description of the invention
Fig. 1 is preparation technology flow chart of the invention.
Specific embodiment
Embodiment 1
A kind of natural vitamin E soft capsule preparation process, including following preparation step:
Step 1: raw material preparation: natural type vitamin E, soybean oil, gelatinum pro capsulae, glycerol, ethyl hydroxy benzoate, purified water, Its composition by weight are as follows: natural type vitamin e1 00g, soybean oil 200g, gelatinum pro capsulae 260g, glycerol 90g, ethyl hydroxy benzoate 2g, purified water 250g;
Step 2: it prepares: being added in ingredients pot by recipe quantity weighing natural type vitamin E, soybean oil, after mixing evenly, Cross 200 meshes, semi-finished product inspection;
Step 3: change glue: by temperature in recipe quantity gelatinum pro capsulae, purified water, glycerol and ethyl hydroxy benzoate investmentization glue tank Control is stirred 2 hours at 80 DEG C, is carried out colloidal sol, is vacuumized;Glue be put in insulation barrel by 120 meshes keep the temperature 24 hours it is standby With;
Step 4: according to the detection level of semi-finished product, prepared natural type vitamin E medical fluid and glue pelleting, sizing: are taken Liquid carries out pelleting, regular check content uniformity, and adjusts in time, and the capsule and pill of extrusion is formed 2 hours in sizing rotating cage, after sizing It is dry;
Step 5: dry: the good capsule and pill of pressed sizing is pulled to drying room and is dried, and temperature controls 18 DEG C, relative humidity ≤ 26%.
Step 6: ball, packaging are picked: carrying out picking ball after dry, rejects unqualified ball;The qualified ball picked is subjected to plastic-aluminum packet Dress, and product inspection is sampled, mounted box, vanning.
Embodiment 2
The preparation step of embodiment 2 is consistent with the preparation step of embodiment 1, and difference is:
Step 3: change glue: by temperature in recipe quantity gelatinum pro capsulae, purified water, glycerol and ethyl hydroxy benzoate investmentization glue tank Control is stirred 2 hours at 85 DEG C, is carried out colloidal sol, is vacuumized;Glue be put in insulation barrel by 120 meshes keep the temperature 24 hours it is standby With;
Step 4: according to the detection level of semi-finished product, prepared natural type vitamin E medical fluid and glue pelleting, sizing: are taken Liquid carries out pelleting, regular check content uniformity, and adjusts in time, and the capsule and pill of extrusion is formed 2.5 hours in sizing rotating cage, is formed After dry;
Step 5: dry: the good capsule and pill of pressed sizing is pulled to drying room and is dried, and temperature controls 22 DEG C, relative humidity ≤ 26%.
Step 6: ball, packaging are picked: carrying out picking ball after dry, rejects unqualified ball;The qualified ball picked is subjected to plastic-aluminum packet Dress, and product inspection is sampled, mounted box, vanning.
Embodiment 3
The preparation step of embodiment 3 is consistent with the preparation step of embodiment 1, and difference is:
Step 3: change glue: by temperature in recipe quantity gelatinum pro capsulae, purified water, glycerol and ethyl hydroxy benzoate investmentization glue tank Control is stirred 2 hours at 90 DEG C, is carried out colloidal sol, is vacuumized;Glue be put in insulation barrel by 120 meshes keep the temperature 24 hours it is standby With;
Step 4: according to the detection level of semi-finished product, prepared natural type vitamin E medical fluid and glue pelleting, sizing: are taken Liquid carries out pelleting, regular check content uniformity, and adjusts in time, and the capsule and pill of extrusion is formed 3 hours in sizing rotating cage, after sizing It is dry;
Step 5: dry: the good capsule and pill of pressed sizing is pulled to drying room and is dried, and temperature controls 26 DEG C, relative humidity ≤ 26%.
Step 6: ball, packaging are picked: carrying out picking ball after dry, rejects unqualified ball;The qualified ball picked is subjected to plastic-aluminum packet Dress, and product inspection is sampled, mounted box, vanning.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding And modification, the scope of the present invention is defined by the appended.

Claims (6)

1. a kind of natural vitamin E soft capsule preparation process, it is characterised in that: the preparation process is as follows:
Step 1: raw material preparation: natural type vitamin E, soybean oil, gelatinum pro capsulae, glycerol, ethyl hydroxy benzoate, purified water, group Point by weight are as follows: natural type vitamin e1 00g, soybean oil 200g, gelatinum pro capsulae 260g, glycerol 90g, ethyl hydroxy benzoate 2g, Purified water 250g;
Step 2: it prepares: being added in ingredients pot by recipe quantity weighing natural type vitamin E, soybean oil, after mixing evenly, look over so as to check Sieve, semi-finished product inspection;
Step 3: changing glue: will carry out colloidal sol in recipe quantity gelatinum pro capsulae, purified water, glycerol and ethyl hydroxy benzoate investmentization glue tank, It vacuumizes;Glue is put in spare in insulation barrel by mesh;
Step 4: pelleting, sizing: according to the detection level of semi-finished product, take prepared natural type vitamin E medical fluid and glue into Row pelleting, regular check content uniformity, and adjust in time, the capsule and pill of extrusion is formed in sizing rotating cage, dry after sizing;
Step 5: dry: the good capsule and pill of pressed sizing is pulled to drying room and is dried, temperature control, controls relative humidity.
Step 6: ball, packaging are picked: carrying out picking ball after dry, rejects unqualified ball;The qualified ball picked progress is aluminum-plastic packaged, And product inspection is sampled, mounted box, vanning.
2. a kind of natural vitamin E soft capsule preparation process according to claim 1, it is characterised in that: the step 2 In, after mixing evenly, cross 200 meshes, semi-finished product inspection.
3. a kind of natural vitamin E soft capsule preparation process according to claim 1, it is characterised in that: the step 3 In, temperature control in recipe quantity gelatinum pro capsulae, purified water, glycerol and ethyl hydroxy benzoate investmentization glue tank is stirred at 80~90 DEG C It mixes 2 hours, carries out colloidal sol.
4. a kind of natural vitamin E soft capsule preparation process according to claim 1, it is characterised in that: the step 3 In, glue be put in insulation barrel by 120 meshes keep the temperature 24 hours it is spare.
5. a kind of natural vitamin E soft capsule preparation process according to claim 1, it is characterised in that: the step 4 In, the capsule and pill of extrusion is formed 2~3 hours in sizing rotating cage, dry after sizing.
6. a kind of natural vitamin E soft capsule preparation process according to claim 1, it is characterised in that: the step 5 In, temperature controls 18 DEG C~26 DEG C, relative humidity≤26%.
CN201910263796.2A 2019-04-02 2019-04-02 A kind of natural vitamin E soft capsule preparation process Pending CN109875975A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112891316A (en) * 2021-02-01 2021-06-04 吉林万通药业有限公司 Vitamin E soft capsule and preparation method thereof

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CN103751146A (en) * 2013-12-11 2014-04-30 天津凯镛药业有限公司 Vitamin E softgel and preparation method thereof
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CN104095826A (en) * 2013-04-12 2014-10-15 宣城柏维力生物工程有限公司 Preparation method of natural vitamin E soft capsule
CN105963350A (en) * 2016-03-16 2016-09-28 安徽珠峰生物科技有限公司 A natural vitamin e soft capsule
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Publication number Priority date Publication date Assignee Title
CN104095826A (en) * 2013-04-12 2014-10-15 宣城柏维力生物工程有限公司 Preparation method of natural vitamin E soft capsule
CN103751146A (en) * 2013-12-11 2014-04-30 天津凯镛药业有限公司 Vitamin E softgel and preparation method thereof
CN104068401A (en) * 2014-06-27 2014-10-01 安徽先知缘食品有限公司 Preparation method for natural vitamin E soft capsules
CN105963350A (en) * 2016-03-16 2016-09-28 安徽珠峰生物科技有限公司 A natural vitamin e soft capsule
CN106666751A (en) * 2016-12-02 2017-05-17 芜湖市诺康生物科技有限公司 Preparation method of vitamin E soft capsule
CN108851063A (en) * 2018-08-03 2018-11-23 汤臣倍健股份有限公司 A kind of Co-Q10 natural vitamin E soft capsule and preparation method thereof

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112891316A (en) * 2021-02-01 2021-06-04 吉林万通药业有限公司 Vitamin E soft capsule and preparation method thereof

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Application publication date: 20190614

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