CN109855392A - A kind of low-temperature microwave vacuum freeze-drying method rich in starch Chinese medicine - Google Patents
A kind of low-temperature microwave vacuum freeze-drying method rich in starch Chinese medicine Download PDFInfo
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Abstract
The invention belongs to Vacuum Freezing & Drying Technology fields, disclose a kind of low-temperature microwave vacuum freeze-drying method rich in starch Chinese medicine, comprising: take the fresh medicinal material of excavation, clean, dissection, obtain cleaning medicinal material；By above-mentioned clean medicinal material in -30 DEG C~-40 DEG C 3~4h of pre-freeze, pre-freeze medicinal material is obtained；Above-mentioned pre-freeze medicinal material is sliced to 20~40mm, dissection medicinal material is obtained；By dissection medicinal material in -25 DEG C~-10 DEG C 80~120min of continuous jelly, continuous jelly medicinal material is obtained once；Jelly medicinal material will once be continued to be sliced to 3~4mm, obtain slice medicinal material；Slice medicinal material is continued in -25 DEG C~-10 DEG C and freezes 40~60min, obtains secondary slice medicinal material；By secondary slice medicinal material in 60~100Pa of vacuum degree and microwave power be under 80~220W dry 2~3h to get.It is an advantage of the current invention that on the basis of the original appearance and active constituent for remaining Chinese medicine of high degree, substantially reducing the time of lyophilization using gradation dicing method stage by stage, reducing vacuum drying cost, convenient for promoting.
Description
Technical field
The invention belongs to Vacuum Freezing & Drying Technology fields, and in particular to a kind of low-temperature microwave rich in starch Chinese medicine is true
Vacuum freecing-dry method.
Background technique
Chinese medicine is many kinds of, from a wealth of sources, is component part more important in China's medical system.The system of Chinese medicine
During standby, the appropriate drying of fresh medicinal material, to the transport of medicinal material, storage, further preparation and the medicine in subsequent prescription
Property have significant impact, if water content is excessively high, in transport, mildew is easy in storing process, if low moisture content is pursued in transition
Content is then easy to cause drying excessively to substantially reduce in subsequent prescription property of traditional Chinese.Currently, the drying of fresh medicinal material generally have with
Lower several ways:
It air-dries: medicinal material is placed on to shady and cool place, make wind dry, its advantage is that it is at low cost, easy to operate, the disadvantage is that dry
The dry time is long, drying efficiency is low, and is affected by weather.
Stove drying is dry: refers to and medicinal material is dried using stove drying, be the current widely used method of processing of crude drugs factory, it should
Method has the advantages that equipment is simple, low in cost, drying time is short, is not restricted by weather, and medicinal material condition obtained beauty
It sees, quality is hard, can prevent from going mouldy and damaging by worms.However, there is also larger defects for this method, such as heavy metal in the medicinal material after stove drying
It is larger with the residual of sulfur dioxide, and the effective active composition of medicinal material itself retains deficiency, leads to the medicine in subsequent prescription
Effect reduces.
Heated-air drying: being one of modern drying means, i.e., hot wind is blown into baking oven or drying room makes air flow faster
Drying means.This method is a little, easy to operate, at low cost, high-efficient, do not restricted by weather.Although heated-air drying pair
The effective active composition retention of medicinal material makes moderate progress, but the protein component retention in medicinal material is substantially reduced.
Vacuum freeze drying: being refrigerated to the below freezing of water for material, be placed in the container of high vacuum (10~40Pa),
Make a kind of drying means of the moisture in material directly from solid ice distillation for steam by heat supply.Vacuum freeze drying is current
The optimal dewatering type of generally acknowledged drying quality, is widely used in food and pharmaceutical industry, is prepared by vacuum freeze drying
Chinese medicine can save the appearance of medicinal material to the maximum extent, various active constituents or oxidizable substance (such as grease type) in medicinal material
Loss may decrease to bottom line, thoroughly, residual moisture amount etc. is down to 5% or less for dehydration.In addition, Vacuum Freezing & Drying Technology
In, because the moisture that dried material contains directly evaporates in the frozen state, therefore in the drying process, steam will not band
Dynamic solable matter shifts to surface of material, it is thin will not to will form hard in surface of material in surface of material Depositional salts
Skin, also there is no the tension generated when shifting to surface of material because of center moisture to cell or fiber, will not make after dry materials because
Contraction causes to deform, therefore easily water suction restores to the original state.
However, although Vacuum Freezing & Drying Technology has the above advantages, but also suffer from certain drawbacks:
(1) refrigeration operation requires stringent, and energy consumption for drying is big, high production cost, is not easy to be widely applied；
(2) in freezing dry process, lyophilization is the maximum step of energy consumption, occupy the 50% of whole process energy consumption with
On；
(3) China's Chinese medicine is many kinds of, distinct, and the parameter of every kind of medicinal material freeze-drying is different and existing
Technique research and development, such as freeze-drying ginseng, freeze-drying Radix Notoginseng, freeze-drying jujube, every one kind is dried generally be directed to a kind of medicinal material in patent
Medicinal material needs individually to research and develop a set of drying process, in general, more spends human and material resources.If to different Chinese medicines using existing
The same freeze-drying parameter having, then effect is bad, and active constituent retains less.
Therefore, if can be shortened the lyophilization time or research and develop the drying process of a kind of Chinese medicine, to freeze-drying skill
The popularization of art is of great significance.For example, having most Chinese medicine content of starch high in Chinese medicine, such as fritillaria thunbergii, Chinese yam, the tuber of pinellia, ginger
Huang, radices trichosanthis, Radix Glehniae, Rhizoma Gastrodiae, Radix Codonopsis and fleece-flower root etc., in the actual production process, if develop one kind adapt to greatly
The lyophilized technique of the rich amyloid Chinese medicine in part, will avoid researching and developing lyophilized technique, wasting manpower and material resources one by one to single medicinal material.Cause
This, present invention is primarily aimed at a kind of vacuum freeze-drying technique is researched and developed, so as to the more medicine of the content of starch suitable for Chinese medicine
Material.
Summary of the invention
In order to solve the above problems existing in the present technology, it is an object of that present invention to provide a kind of rich in starch Chinese medicine
Low-temperature microwave vacuum freeze-drying method.
The technical scheme adopted by the invention is as follows:
A kind of low-temperature microwave vacuum freeze-drying method rich in starch Chinese medicine, includes the following steps:
(1) it samples: taking the fresh medicinal material of excavation, clean, dissection, obtain cleaning medicinal material；
(2) pre-freeze: by above-mentioned clean medicinal material at -30 DEG C~-40 DEG C 3~4h of pre-freeze, obtain pre-freeze medicinal material；
(3) primary slice: above-mentioned pre-freeze medicinal material is sliced to 20~40mm, dissection medicinal material is obtained；
(4) low-temperature distillations: by the dissection medicinal material at -25 DEG C~-10 DEG C 80~120min of low-temperature distillation, obtain
Primary continuous jelly medicinal material；
(5) secondary slice: the primary continuous medicinal material that freezes is sliced to 3~4mm, slice medicinal material is obtained；
(6) secondary low-temperature distillation: by the slice medicinal material at -25 DEG C~-10 DEG C 40~60min of low-temperature distillation, obtain
Secondary slice medicinal material；
(7) microwave vacuum freeze is dry: will the secondary slice medicinal material in 60~100Pa of vacuum degree and microwave power be 80
Dry 2~3h is under the conditions of~220W to get rich in starch Chinese medicine.
Preferably, the above-mentioned low-temperature microwave vacuum freeze-drying method rich in starch Chinese medicine, the thickness being once sliced
Degree is 30mm.
Preferably, the above-mentioned low-temperature microwave vacuum freeze-drying method rich in starch Chinese medicine, it is described it is primary continuous freeze when
Between be 2h.
Preferably, the above-mentioned low-temperature microwave vacuum freeze-drying method rich in starch Chinese medicine, the secondary continuous jelly when
Between be 1h.
Preferably, the above-mentioned low-temperature microwave vacuum freeze-drying method rich in starch Chinese medicine, the vacuum degree are 80Pa.
Preferably, the above-mentioned low-temperature microwave vacuum freeze-drying method rich in starch Chinese medicine, the microwave vacuum freeze
It is dry to include the following steps, dry 2 under the conditions of being 140W in vacuum degree 80Pa and microwave power by the secondary slice medicinal material~
2.5h is 10~20min dry under the conditions of 220W then at vacuum degree 100Pa and microwave power.
Preferably, the above-mentioned low-temperature microwave vacuum freeze-drying method rich in starch Chinese medicine, the middle rotation of the step (7)
Speed is 7.5~10r/min.
Preferably, the above-mentioned low-temperature microwave vacuum freeze-drying method rich in starch Chinese medicine, the pre-freezing temperature are -35
DEG C, the pre-freeze time is 3.5h.
Preferably, the above-mentioned low-temperature microwave vacuum freeze-drying method rich in starch Chinese medicine, the length of the clean medicinal material
Degree is 8~10cm.
The invention has the benefit that
Low-temperature microwave vacuum freeze-drying method provided by the invention rich in starch Chinese medicine, using low-temperature-rise stage by stage
The method of China and stage by stage microwave drying, on the original appearance for remaining Chinese medicine of high degree and the basis of active constituent
On, the dry time is substantially reduced, vacuum drying cost is reduced, and is applicable to most of rich in starch Chinese medicine
Freeze-drying, such as pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis, Radix Glehniae, Rhizoma Gastrodiae, Radix Codonopsis and the fleece-flower root, convenient for promoting.
Detailed description of the invention
Fig. 1 is cold using vacuum freeze-drying method and the low-temperature microwave vacuum provided by the invention rich in starch Chinese medicine
The relative water content that the dry pueraria lobata of drying method is lyophilized changes schematic diagram；
Fig. 2 is the relative water content variation signal using the pueraria lobata of 1 group of parameter preparation, Chinese yam, the root of Dahurain angelica and radices trichosanthis medicine materical crude slice
Figure；
Fig. 3 is the relative water content variation signal using the pueraria lobata of 2 groups of parameters preparation, Chinese yam, the root of Dahurain angelica and radices trichosanthis medicine materical crude slice
Figure；
Fig. 4 is the relative water content variation signal using the pueraria lobata of 3 groups of parameters preparation, Chinese yam, the root of Dahurain angelica and radices trichosanthis medicine materical crude slice
Figure；
Fig. 5 is the relative water content variation signal using the pueraria lobata of 4 groups of parameters preparation, Chinese yam, the root of Dahurain angelica and radices trichosanthis medicine materical crude slice
Figure.
Specific embodiment
Test example does further explaination to the present invention with reference to the accompanying drawing and specifically.
Test example 1
The purpose of this test example is to compare conventional vacuum freeze-drying method and freeze-drying method provided by the invention
Drying effect.
Fresh Chinese medicine pueraria lobata is taken, is cleaned, surface sludge is removed, dissection to 8~10cm long is spare；By shown in table 1 points
Group, specific as follows:
Table 1
Wherein, each group specific steps are as follows:
A group: fresh pueraria lobata is switched to small cube, with a thickness of 0.5cm~1cm, is sliced；It is pre- by -40 DEG C of previous slice
Freeze 5h；The dry 12h of -20 DEG C of low-temperature distillations；30 DEG C of dry 10h are to get to dry pueraria lobata medicine materical crude slice.
B group: by aforementioned fresh pueraria lobata in -40 DEG C of pre-freeze 4h；Medicine materical crude slice is switched to small cube, with a thickness of 3cm, and in -25 DEG C
Low-temperature distillation 2h；Aforementioned small cube is switched to 3~4mm again, slice is continued at into -25 DEG C of low-temperature distillation 1h；It is revolved in 60Pa, 220W
Become a cadre dry 10h, and rotation speed is 7.5r/min~10r/min to get to dry pueraria lobata medicine materical crude slice.
Prepare two groups of pueraria lobata medicine materical crude slice respectively according to aforesaid operations step, it is as follows, dry in parsing-desiccation or microwave
During dry, piece is drunk every 2h and carries out determination of moisture, determination of moisture mode is as follows:
The Gegen tablets prepared in test group A and B are taken, crushes, obtains powder.It weighs powder 2g to be placed in weighing bottle, open
Bottle cap 100 DEG C~105 DEG C drying 5 hours, cover in bottle cap dislocation drier, cooling 30 minutes, accurately weighed weight, then
Above-mentioned temperature is 1 hour dry, cooling, weighing, until the difference weighed twice in succession is no more than 5mg.Different time sections pueraria lobata
Water content (%) calculation formula is in medicine materical crude slice
, the content water of two groups of pueraria lobata medicine materical crude slice is calculated separately by above-mentioned formula, with the water content of each time point divided by this
Lower water content of the medicine materical crude slice at 0 hour of group obtains the relative water content of each timing node multiplied by 100%.
Each group medicine materical crude slice relative water content changes over time as shown in Figure 1.As shown in Figure 1, relative to vacuum freeze drying side
Method, the low-temperature microwave vacuum freeze-drying method rich in starch Chinese medicine can be in 0~6h, and the major part reduced in medicine materical crude slice is aqueous
It measures (80% or more), shows that (being sliced+be segmented low-temperature distillation+segmentation microwave drying stage by stage) method provided by the invention is obviously excellent
In common vacuum freeze drying.
Test example 2
The purpose of this test example, which is to seek, a kind of can be suitble to a variety of low-temperature microwave vacuum refrigerations rich in starch Chinese medicine
Drying means.
Although clear in test example 1 low-temperature distillation+segmentation method for microwave drying is sliced+be segmented stage by stage be substantially better than tradition
Vacuum freeze-drying method, but in experiments it is found that, it is micro- using being sliced+being segmented low-temperature distillation+segmentation stage by stage in test example 1
The pueraria lobata medicine materical crude slice that the parameter of wave drying means obtains, in 4h, medicine materical crude slice surface has turned yellow, and has removed when 4h big in medicine materical crude slice
Part moisture content reduces nothing to water content and obviously benefits after 4h.By constantly groping, inventors have found that pueraria lobata medicine materical crude slice
Optimum drying technique is as follows: -40 DEG C of pre-freeze 3h；Slice thickness a 30mm, -22 DEG C of low temperature drying 2h；Secondary slice to 3~
4mm, -22 DEG C of low temperature drying 1h；Primary vacuum drying 60Pa, 100W, rotarily dry 2.5h；Secondary vacuum dries 100Pa,
220W rotarily dries 10~20min.But since every kind of Chinese medicine has certain difference, drying parameter is also not quite similar.Cause
This, is dried a variety of medicinal materials using different parameters by following manner, explores the medicine materical crude slice that can adapt to four kinds of Chinese medicines simultaneously
Manufacture craft.
1 grouping: taking fresh pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis, cleans, and removes surface sludge, spare；It is tried by shown in table 2
Parameter grouping is tested, specific as follows:
Table 2
The preparation of 2.1 medicine materical crude slice
Referring to table 2, pharmaceutical decocting piece is prepared as follows:
(1) it samples: taking fresh pueraria lobata, Chinese yam, the root of Dahurain angelica and the radices trichosanthis just excavated, clean, dissection to 8~10cm long obtains
To clean medicinal material；
(2) pre-freeze: by above-mentioned clean medicinal material at -30 DEG C~-40 DEG C 3~4h of pre-freeze, obtain pre-freeze medicinal material；
(3) primary slice: above-mentioned pre-freeze medicinal material is sliced to 20~40mm, dissection medicinal material is obtained；
(4) low-temperature distillations: by the dissection medicinal material at -25 DEG C~-10 DEG C 80~120min of low-temperature distillation, obtain
Primary continuous jelly medicinal material；
(5) secondary slice: the primary continuous medicinal material that freezes is sliced to 3~4mm, slice medicinal material is obtained；
(6) secondary low-temperature distillation: by the slice medicinal material at -25 DEG C~-10 DEG C 40~60min of low-temperature distillation, obtain
Secondary slice medicinal material；
(7) microwave vacuum freeze is dry: will the secondary slice medicinal material in 60~100Pa of vacuum degree and microwave power be 80
2~3h is rotarily dried under the conditions of~220W, rotation speed is preferred 7.5~10r/min to get rich in starch Chinese medicine.
Specific each group parameter is referring to table 2, and by pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis, respectively medicine materical crude slice obtained carries out water content
Measurement (wherein angelica dahurica decoction pieces water content is referring to the 4th method of " Chinese Pharmacopoeia " (2010) general rule 0832), once contains every 0.5h measurement
Water.
Pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis medicine materical crude slice, pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis are prepared using 1 group of technique respectively
Medicine materical crude slice different dry time points relative water content variation as shown in Fig. 2, pueraria lobata medicine materical crude slice eliminates most of moisture content in 1.5h,
Chinese yam medicine materical crude slice eliminates most of moisture content, the root of Dahurain angelica and radices trichosanthis in 2h and eliminates most of moisture content in 2h.
Pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis medicine materical crude slice, pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis are prepared respectively using 2 groups of techniques
Relative water content of the medicine materical crude slice at different dry time points changes as shown in figure 3, pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis medicine materical crude slice exist
1.5h eliminates most of moisture content, and in 2h, relative water content is lower than 15%.
Pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis medicine materical crude slice, pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis are prepared respectively using 3 groups of techniques
Medicine materical crude slice different dry time points relative water content variation as shown in figure 4, pueraria lobata medicine materical crude slice eliminates most of moisture content in 2.5h,
Chinese yam medicine materical crude slice eliminates most of moisture content, the root of Dahurain angelica and radices trichosanthis in 1.5h and eliminates most of moisture content in 2h.
Pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis medicine materical crude slice, pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis are prepared respectively using 4 groups of techniques
Relative water content of the medicine materical crude slice at different dry time points changes as shown in figure 5, pueraria lobata medicine materical crude slice eliminates most of moisture content, mountain in 3h
Medicine and radices trichosanthis medicine materical crude slice eliminate most of moisture content in 2.5h, and the root of Dahurain angelica eliminates most of moisture content in 1.5h.
It follows that being suitable for the best preparation parameter of pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis simultaneously are as follows: -40 DEG C of pre-freezes
3h；Slice thickness a 30mm, -20 DEG C of low temperature drying 2h；It is secondary to be sliced to 3~4mm, -20 DEG C of low temperature drying 1h；Vacuum
Dry 80Pa, 140W, rotarily dry 2h；Secondary vacuum dries 100Pa, 220W, rotarily dries 10~20min.
Test example 3
The purpose of this test example is whether the parameters for verifying the medicine materical crude slice that above-mentioned test example provides are up to standard.
1 test material
Pueraria lobata, Chinese yam, the root of Dahurain angelica and the radices trichosanthis for taking fresh excavation, are cleaned respectively, spare.
2 test methods and result
Pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis medicine materical crude slice are prepared referring to the optimized parameter that test example 2 obtains.
2.1 water content, total ash, extract, total protein and determination of total flavonoids
2.1.1 moisture determination
The moisture determination of pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis is referring to test example 1.
2.1.2 total ash measures
Total ash content mensuration mode is as follows in pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis medicine materical crude slice: by the pueraria lobata of crushing, Chinese yam,
The root of Dahurain angelica and Snakegourd Root sieving, after mixing, take 2g, set in the 25mL crucible of ignition to constant weight, weighed weight is (accurately extremely
0.01g), slowly red-hot, pay attention to avoiding burning, until gradually rising temperature when carbonizing completely to 500-600 DEG C, making to be ashed completely
And to constant weight.According to residue weight, the content (%) of total ash in test sample is calculated.Blazing 5h, later each 30min, continuously
The difference weighed after blazing twice is in 0.3mg or less.
2.1.3 extract content measures
Extract content mensuration mode is as follows in Chinese yam and radices trichosanthis: the Chinese yam of crushing and Snakegourd Root being sieved, mixed
After closing uniformly, Chinese yam and radices trichosanthis sample about 4g are taken, it is accurately weighed, it sets in the conical flask of 250mL, precision plus water 100mL are close
Plug, cold soaking constantly shakes in first 6 hours, then stands 18 hours, is filtered rapidly with dry filter, and precision measures subsequent filtrate 20mL,
It is placed in and has dried into the evaporating dish of constant weight, it is 3 hours dry in 105 DEG C after being evaporated in water-bath, it sets 30 points cooling in drier
Clock, rapid accurately weighed weight.The content (%) of water-soluble extractives in Chinese yam and radices trichosanthis is calculated with dry product.Pueraria lobata and white
Hot dipping under the ash determination reference " Chinese Pharmacopoeia " (2010) general rule 2201 of the root of Dahurian angelica, is measured with Diluted Alcohol as solvent.
2.1.4 total protein content measures
It is specific as follows: accurate using the total protein content in Bradford method measurement Chinese yam, pueraria lobata radices trichosanthis medicine materical crude slice powder
Chinese yam, each 0.1g of pueraria lobata Snakegourd Root are weighed, distilled water is added to grind, constant volume 5mL, 3000r/min are centrifuged 5min, supernatant
For sample liquid.The bovine serum albumen solution (BSA) of various concentration is used as standard solution, takes standard solution and sample liquid each respectively
5mL Coomassie Brillant Blue solution is added thereto, after shaking up, measures absorbance under 595nm by 1mL.With bovine serum albumen solution
(BSA) content draws standard curve to absorbance, calculates pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis sample powder according to standard curve
Middle total protein content.
2.1.5 determination of total flavonoids
The continuous mode of general flavone content is as follows in Chinese yam, pueraria lobata and the root of Dahurain angelica: accurately weighing rutin 1.07mg, ethyl alcohol constant volume
To 5mL, it is made into the rutin standard solution that concentration is 0.214mg/mL.Take respectively rutin standard solution 0.3mL, 0.6mL, 0.9mL,
NaNO is added in 10mL volumetric flask in 1.2mL and 1.5mL2Solution (5%) 0.4mL, which shakes up, places 6min, and Al (NO is added3)3It is molten
Liquid (10%) 0.4mL places 6min.Finally plus NaOH solution (4%) 4mL, rear plus ethyl alcohol are settled to scale.It shakes up, places
15min measures absorbance at 510nm, calculates general flavone content by calibration curve method.
2.2 result
Containing for pueraria lobata under the optimized parameter that test example 2 obtains, Chinese yam, the root of Dahurain angelica and radices trichosanthis medicine materical crude slice is measured according to foregoing manner
Water, total ash, extract, total protein and general flavone content result are as shown in table 3:
Table 3
Note: the optimized parameter that above-mentioned " optimized parameter " i.e. test example 2 obtains is test example, and above-mentioned " routine " is vacuum refrigeration
Drying means.
As shown in Table 3, under the optimized parameter that test example 2 obtains, pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis medicine materical crude slice water content,
Total ash, extract are able to satisfy the requirement of " Chinese Pharmacopoeia " (2010), in addition, under this group of parameter, pueraria lobata, Chinese yam, the root of Dahurain angelica and
The total protein and general flavone of radices trichosanthis medicine materical crude slice are significantly better than normal freeze-drying method, show low-temperature microwave provided by the invention
Vacuum freeze-drying method is applicable to rich amyloid Chinese medicine, is particularly suitable for the drink of pueraria lobata, Chinese yam, the root of Dahurain angelica and radices trichosanthis
Piece production.
The present invention is not limited to above-mentioned optional embodiment, anyone can show that other are each under the inspiration of the present invention
The product of kind form.Above-mentioned specific embodiment should not be understood the limitation of pairs of protection scope of the present invention, protection of the invention
Range should be subject to be defined in claims, and specification can be used for interpreting the claims.
Claims (9)
1. a kind of low-temperature microwave vacuum freeze-drying method rich in starch Chinese medicine, which comprises the steps of:
(1) it samples: taking the fresh medicinal material of excavation, clean, dissection, obtain cleaning medicinal material；
(2) pre-freeze: by above-mentioned clean medicinal material at -30 DEG C~-40 DEG C 3~4h of pre-freeze, obtain pre-freeze medicinal material；
(3) primary slice: above-mentioned pre-freeze medicinal material is sliced to a thickness of 20~40mm, dissection medicinal material is obtained；
(4) low-temperature distillations: by the dissection medicinal material at -25 DEG C~-10 DEG C 80~120min of low-temperature distillation, obtain primary
It is continuous to freeze medicinal material；
(5) secondary slice: the primary continuous medicinal material that freezes is sliced to a thickness of 3~4mm, slice medicinal material is obtained；
(6) secondary low-temperature distillation: by the slice medicinal material at -25 DEG C~-10 DEG C 40~60min of low-temperature distillation, obtain secondary
It is sliced medicinal material；
(7) microwave vacuum freeze is dry: will the secondary slice medicinal material in 60~100Pa of vacuum degree and microwave power for 80~
2~3h is rotarily dried under the conditions of 220W to get starch Chinese medicine is rich in.
2. the low-temperature microwave vacuum freeze-drying method according to claim 1 rich in starch Chinese medicine, it is characterised in that:
It is described be once sliced with a thickness of 30mm.
3. the low-temperature microwave vacuum freeze-drying method according to claim 2 rich in starch Chinese medicine, it is characterised in that:
The primary continuous time frozen is 2h.
4. the low-temperature microwave vacuum freeze-drying method according to claim 3 rich in starch Chinese medicine, it is characterised in that:
The time of the secondary continuous jelly is 1h.
5. the low-temperature microwave vacuum freeze-drying method of starch Chinese medicine is rich according to claim 2-4 any one,
It is characterized by: the vacuum degree is 80Pa.
6. the low-temperature microwave vacuum freeze-drying method according to claim 5 rich in starch Chinese medicine, it is characterised in that:
The microwave vacuum freeze drying includes the following steps, is in vacuum degree 80Pa and microwave power by the secondary slice medicinal material
Dry 2~2.5h under the conditions of 140W is 10~20min dry under the conditions of 220W then at vacuum degree 100Pa and microwave power.
7. the low-temperature microwave vacuum freeze-drying method according to claim 6 rich in starch Chinese medicine, it is characterised in that:
Rotation speed is 7.5~10r/min in the step (7).
8. the low-temperature microwave vacuum freeze-drying method according to claim 1 rich in starch Chinese medicine, it is characterised in that:
The pre-freezing temperature is -35 DEG C, and the pre-freeze time is 3.5h.
9. the low-temperature microwave vacuum freeze-drying method according to claim 1 rich in starch Chinese medicine, it is characterised in that:
The length of the clean medicinal material is 8~10cm.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111772188A (en) * | 2020-07-07 | 2020-10-16 | 河北智同生物制药股份有限公司 | Liver polypeptide for protecting liver and improving liver function and composition thereof |
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