CN109853054A - A kind of device and building method of coaxial electrostatic spinning 3 D-printing biological support - Google Patents
A kind of device and building method of coaxial electrostatic spinning 3 D-printing biological support Download PDFInfo
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- CN109853054A CN109853054A CN201910183074.6A CN201910183074A CN109853054A CN 109853054 A CN109853054 A CN 109853054A CN 201910183074 A CN201910183074 A CN 201910183074A CN 109853054 A CN109853054 A CN 109853054A
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- coaxial electrostatic
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- 238000010041 electrostatic spinning Methods 0.000 title claims abstract description 49
- 238000007639 printing Methods 0.000 title claims abstract description 43
- 238000000034 method Methods 0.000 title claims abstract description 19
- 238000009987 spinning Methods 0.000 claims abstract description 35
- 239000007921 spray Substances 0.000 claims abstract description 23
- 238000005070 sampling Methods 0.000 claims description 9
- 230000033001 locomotion Effects 0.000 claims description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
- 239000000741 silica gel Substances 0.000 claims description 5
- 229910002027 silica gel Inorganic materials 0.000 claims description 5
- 239000012530 fluid Substances 0.000 claims description 4
- 239000003814 drug Substances 0.000 abstract description 8
- 238000005516 engineering process Methods 0.000 abstract description 7
- 239000000835 fiber Substances 0.000 abstract description 7
- 238000007306 functionalization reaction Methods 0.000 abstract description 5
- 239000002105 nanoparticle Substances 0.000 abstract description 4
- 108090000623 proteins and genes Proteins 0.000 abstract description 4
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000004372 Polyvinyl alcohol Substances 0.000 description 5
- 239000003658 microfiber Substances 0.000 description 5
- 239000002121 nanofiber Substances 0.000 description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 description 5
- 229960003405 ciprofloxacin Drugs 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000005684 electric field Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000011258 core-shell material Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229920001610 polycaprolactone Polymers 0.000 description 2
- 239000004632 polycaprolactone Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000007711 solidification Methods 0.000 description 2
- 230000008023 solidification Effects 0.000 description 2
- BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical compound FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 description 1
- SDGKUVSVPIIUCF-UHFFFAOYSA-N 2,6-dimethylpiperidine Chemical compound CC1CCCC(C)N1 SDGKUVSVPIIUCF-UHFFFAOYSA-N 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- -1 hexafluoro isopropyl Chemical group 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000000110 selective laser sintering Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Landscapes
- Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
Abstract
The invention belongs to three dimensional biological printing technique fields, the in particular a kind of device and building method of coaxial electrostatic spinning 3 D-printing biological support, described device includes rack body, feeding device is fixedly connected at the top of the rack body, the building method specifically comprises the following steps: that spinning nozzle is connect with high pressure generator, reception device is placed in underface, adjusts mobile station to control spinning distance；Barrel temperature control device is installed outside feeding device；The present invention passes through setting coaxial electrostatic spinning spray head, feeding device, temperature control device, mobile station, reception device, HV generator, kinetic control system and temperature and humidity control system, this device combines coaxial electrostatic spinning technology with 3 D-printing, the precision of 3 D-printing can be improved, it can be conducive to the raising and functionalization of the precision of 3 D-printing biological support in stratum nucleare carrying medicaments, cell factor, gene and the nanoparticle in electrospun fibers.
Description
Technical field
The invention belongs to three dimensional biological printing technique fields, and in particular to a kind of coaxial electrostatic spinning 3 D-printing biology branch
The device and building method of frame.
Background technique
Three dimensional biological printing technique quickly prepares the technology of biological support by way of successively printing stacking, can be by life
Object file printing becomes the three-dimensional structure being pre-designed.At present the major technique of 3 D-printing have fusion sediment rapid shaping,
The modes such as Stereolithography, selective laser sintering, wherein in 3 D-printing bracket using it is wider be FDM mode.It is logical
It crosses and squeezes out biomaterial heating melting from nozzle again, track and deposition velocity according to the movement of default fuse, can be quick
To 3 D-printing bracket.But due to by jet diameters limited and fiber squeeze out after bulking effect so that squeeze out fibre
It is thicker to tie up diameter, causes three-dimensional structure accuracy made of accumulating with this poor, the printing for not being able to satisfy micro/nano structure is wanted
It asks.
Coaxial electrostatic spinning technology can obtain the micro/nano-fibre material with core-shell structure, can pass through stratum nucleare material
Material improves mechanical strength, or by stratum nucleare carrying medicaments, bioactie agent etc., so that material has more the spy of functionalization
Point, practicability are stronger.Coaxial electrostatic spinning technology can improve the precision of 3 D-printing, and obtaining has core-shell structure micro-/ nano fine
The three-dimensional structure of dimension and more conducively biocompatible.The solidification of electrospun fibers is acted on by electrostatic drawing-off, band Electrospun
Solvent volatilization and jet stream pre-cooling solidification rapidly in the movement of liquid in the electric field, drug, bioactie agent are in the curing process
It is less subject to influence, coaxial electrostatic spinning technology is combined with 3 D-printing, the precision of 3 D-printing can be improved, it can be quiet
Stratum nucleare carrying medicaments, cell factor, gene and nanoparticle in electricity spinning fibre etc. are conducive to the essence of 3 D-printing bracket
The raising and functionalization of degree.
Summary of the invention
To solve the problems mentioned above in the background art.It is raw that the present invention provides a kind of coaxial electrostatic spinning 3 D-printings
The device and building method of object bracket have the characteristics that can be improved 3 D-printing precision.
To achieve the above object, the invention provides the following technical scheme: a kind of coaxial electrostatic spinning 3 D-printing biology branch
The device of frame, including rack body are fixedly connected with feeding device, the bottom of the feeding device at the top of the rack body
It is provided with coaxial electrostatic spinning spray head, the outside of the coaxial electrostatic spinning spray head is provided with temperature control device, the right side of the bracket
Side is provided with temperature and humidity control system and HV generator, and the HV generator is located at temperature and humidity control system
Lower section, the coaxial electrostatic spinning spray head are connect with HV generator, and the bracket is internally provided with mobile station and connects
Receiving apparatus, and connection is fixed by the connecting rod at the top of the bottom of reception device and mobile station, the input terminal of the mobile station is logical
It crosses conducting wire and is electrically connected with kinetic control system, the kinetic control system is located at the left side of bracket.
Preferably, the coaxial electrostatic spinning spray head is made of inside and outside two layers of coaxial pipes, and inside and outside two layers of pipeline leads to respectively
Excessively high elastic silica gel hose is connected with internal layer and outer layer Fluid feeding devices.
Preferably, the feeding device is internally provided with barrel, and the outside of barrel is provided with temperature control device.
Preferably, the coaxial electrostatic spinning spray head can add multiple groups.
A kind of building method of coaxial electrostatic spinning 3 D-printing biological support, the building method specifically include following step
It is rapid:
(1) spinning nozzle is connect with high pressure generator, underface place reception device, adjust mobile station come control spinning away from
From；
(2) barrel temperature control device is installed outside feeding device, spray head temperature control device is installed outside spinning nozzle；
(3) coaxial electrostatic spinning silk device is fixed on bracket, is connected with external control system, regulation and control system, control
Reception device completes three-dimensional motion；
(4) temperature and humidity of whole device is controlled to keep the external environment of entire spinning process；
(5) high pressure generator and sampling device are opened, spinning jet is made to be in semi-solid preparation under the action of high-pressure electrostatic
State is simultaneously constantly stacked into reception device, obtains coaxial electrostatic spinning 3 D-printing biological support.
Compared with prior art, the beneficial effects of the present invention are:
The present invention passes through setting coaxial electrostatic spinning spray head, feeding device, temperature control device, mobile station, reception device, high pressure
Electrostatic generator, kinetic control system and temperature and humidity control system, this device is by coaxial electrostatic spinning technology and 3 D-printing phase
In conjunction with, the precision of 3 D-printing can be improved, can in electrospun fibers stratum nucleare carrying medicaments, cell factor, gene with
And nanoparticle, be conducive to the raising and functionalization of the precision of 3 D-printing biological support.
Detailed description of the invention
Attached drawing is used to provide further understanding of the present invention, and constitutes part of specification, with reality of the invention
It applies example to be used to explain the present invention together, not be construed as limiting the invention.In the accompanying drawings:
Fig. 1 is the schematic diagram of the section structure of coaxial electrostatic spinning spray head of the present invention amplification；
Fig. 2 is a kind of structural schematic diagram of the device of coaxial electrostatic spinning 3 D-printing biological support of the present invention；
Fig. 3 is present invention printing biological support schematic diagram；
In figure: 1, coaxial electrostatic spinning spray head；2, feeding device；3, temperature control device；4, mobile station；5, reception device；6,
HV generator；7, kinetic control system；8, temperature and humidity control system；9, rack body.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Please refer to Fig. 1-3, the present invention is the following technical schemes are provided: a kind of coaxial electrostatic spinning 3 D-printing biological support
Device, including rack body 9, the top of the rack body 9 are fixedly connected with feeding device 2, the bottom of the feeding device 2
It is provided with coaxial electrostatic spinning spray head 1, the outside of the coaxial electrostatic spinning spray head 1 is provided with temperature control device 3, the bracket sheet
The right side of body 9 is provided with temperature and humidity control system 8 and HV generator 6, and the HV generator 6 is located at temperature and humidity
The lower section of control system 8, the coaxial electrostatic spinning spray head 1 are connect with HV generator 6, and the inside of the bracket 9 is set
It is equipped with mobile station 4 and reception device 5, and the bottom of reception device 5 is fixed by the connecting rod with the top of mobile station 4 and connect, institute
The input terminal for stating mobile station 4 is electrically connected with kinetic control system 7 by conducting wire, and the kinetic control system 7 is located at a left side for bracket 9
Side, the present invention pass through setting coaxial electrostatic spinning spray head 1, feeding device 2, temperature control device 3, mobile station 4, reception device 5, high pressure
Electrostatic generator 6, kinetic control system 7 and temperature and humidity control system 8, this device is by coaxial electrostatic spinning technology and 3 D-printing
It combines, the precision of 3 D-printing can be improved, it can be in stratum nucleare carrying medicaments, cell factor, the gene in electrospun fibers
And nanoparticle, be conducive to the raising and functionalization of the precision of 3 D-printing biological support.
Specifically, the coaxial electrostatic spinning spray head 1 is made of inside and outside two layers of coaxial pipes, inside and outside two layers of pipeline leads to respectively
Excessively high elastic silica gel hose is connected with internal layer and outer layer Fluid feeding devices 2, by using high resiliency silica gel hose so as to
It enough prevents from leaking outside.
Specifically, the feeding device 2 is internally provided with barrel, and the outside of barrel is provided with temperature control device 3, passes through
Temperature control device 3 is controlled to keep the external environment of entire spinning process.
Specifically, the coaxial electrostatic spinning spray head 1 can add multiple groups, it can satisfy different materials by adding multiple groups
The demand that can be printed simultaneously improves spinning efficiency.
A kind of building method of coaxial electrostatic spinning 3 D-printing biological support, the building method specifically include following step
It is rapid:
(1) coaxial spinning nozzle is made of inside and outside two layers of coaxial pipes, and inside and outside two layers of pipeline passes through high resiliency silica gel respectively
Hose is connected (Fig. 1) with internal layer and outer layer Fluid feeding devices, and coaxial spinning nozzle can add multiple groups, meet different materials
The demand that can be printed simultaneously improves spinning efficiency, and spinning nozzle is connect with high pressure generator, and reception device is placed in underface, adjusts
Mobile station is saved to control spinning distance；
(2) barrel temperature control device is installed outside feeding device, spray head temperature control device is installed outside spinning nozzle；
(3) coaxial electrostatic spinning silk device is fixed on bracket, is connected with external control system, regulation and control system, control
Reception device completes three-dimensional motion；
(4) temperature/humidity of whole device is controlled to keep the external environment of entire spinning process；
(5) high pressure generator and sampling device are opened, spinning jet is made to be in semi-solid preparation under the action of high-pressure electrostatic
State is simultaneously constantly stacked into reception device, is obtained coaxial electrostatic spinning 3 D-printing biological support (Fig. 3).
Embodiment 1
(1) 15% polycaprolactone is in hexafluoroisopropanol solution as shell solution, and 20% polyvinyl alcohol is in hexafluoro isopropyl
Alcoholic solution adds the 1-10% that ciprofloxacin pharmaceutical accounts for polyvinyl alcohol quality in core solution, solution is distinguished as core solution
It injects in two sampling devices of nucleocapsid, it is 0.5mm/min that rate is injected in adjustment；
(2) both ends of ac high voltage source are connected with syringe needle and reception device respectively, adjusts ac high voltage source voltage
For 5-25kV；
(3) distance for adjusting receiver board and syringe needle is 5-15cm, makes the drop injected out under the action of high voltage electric field
Drawing-off is obtained, micro/nano-fibre is formed；
(4) temperature/humidity of whole device is adjusted at 4 DEG C, 20%, and the external environment of entire spinning process is kept to stablize；
(5) motion profile for adjusting mobile station, so that micro/nano-fibre is according to the three-dimensional structure being pre-designed mobile
It is deposited in reception device.
Embodiment 2
(1) polycaprolactone is separately heated to melt with granule of polyvinyl alcohol, Ciprofloxacin medicine is added in polyvinyl alcohol
Object, addition ciprofloxacin pharmaceutical account for the 1-10% of polyvinyl alcohol quality, remove the bubble inside melt, melt is injected separately into core
In two sampling devices of shell, it is 0.5mm/min that rate is injected in adjustment；
(2) both ends of ac high voltage source are connected with syringe needle and reception device respectively, adjusts ac high voltage source voltage
For 5-25kV；
(3) distance for adjusting receiver board and syringe needle is 5-15cm, makes the drop injected out under the action of high voltage electric field
Drawing-off is obtained, micro/nano-fibre is formed；
(4) temperature/humidity of whole device is adjusted at 4 DEG C, 20%, and the external environment of entire spinning process is kept to stablize；
(5) motion profile of mobile station is adjusted, so that micro/nano-fibre is according to the three-dimensional structure of pre-selection design mobile
It is deposited in reception device.
The working principle of the invention and process for using:
1. the installation of device: two kinds of spinning solutions of nucleocapsid being packed into sampling device, drug, biology can be added in core solution
Active factors etc., sampling device is installed together with charging barrel heating device, and spinning nozzle is placed on barrel, outside coaxial spinning nozzle
Injector heating arrangement is installed, coaxial spinning nozzle is connected (Fig. 2) with high-voltage power-line；
2. the setting of spinning parameter: controlling temperature/humidity of whole device to keep the external environment of entire spinning process steady
It is fixed, mobile station is adjusted to control spinning distance, and the voltage for adjusting high voltage power supply enables spinning solution to form stable jet stream, adjusts
The flow velocity for saving sampling device, controls the speed of spinning；
3. starting coaxial electrostatic spinning 3 D-printing bracket: high pressure generator and sampling device are opened, in high-pressure electrostatic
Effect is lower so that spinning jet is in semi-cured state and is constantly stacked into reception device, and acquisition coaxial electrostatic spinning three-dimensional is beaten
Print biological support.
Finally, it should be noted that the foregoing is only a preferred embodiment of the present invention, it is not intended to restrict the invention,
Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, still may be used
To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features.
All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in of the invention
Within protection scope.
Claims (5)
1. a kind of device of coaxial electrostatic spinning 3 D-printing biological support, including rack body (9), it is characterised in that: described
It is fixedly connected at the top of rack body (9) feeding device (2), the bottom of the feeding device (2) is provided with coaxial electrostatic spinning
Silk spray head (1), the outside of the coaxial electrostatic spinning spray head (1) is provided with temperature control device (3), sets on the right side of the bracket (9)
It is equipped with temperature and humidity control system (8) and HV generator (6), the HV generator (6) is located at Temperature and Humidity Control
The lower section of system (8), the coaxial electrostatic spinning spray head (1) connect with HV generator (6), the bracket (9) it is interior
Portion is provided with mobile station (4) and reception device (5), and passes through connecting rod at the top of the bottom of reception device (5) and mobile station (4)
It is fixedly connected, the input terminal of the mobile station (4) is electrically connected with kinetic control system (7) by conducting wire, the motion control system
System (7) is located at the left side of bracket (9).
2. a kind of device of coaxial electrostatic spinning 3 D-printing biological support according to claim 1, it is characterised in that: institute
It states coaxial electrostatic spinning spray head (1) to be made of inside and outside two layers of coaxial pipes, it is soft that inside and outside two layers of pipeline passes through high resiliency silica gel respectively
Pipe is connected with internal layer and outer layer Fluid feeding devices (2).
3. a kind of device of coaxial electrostatic spinning 3 D-printing biological support according to claim 1, it is characterised in that: institute
The barrel that is internally provided with of feeding device (2) is stated, and the outside of barrel is provided with temperature control device (3).
4. a kind of device of coaxial electrostatic spinning 3 D-printing biological support according to claim 2, it is characterised in that: institute
Multiple groups can be added by stating coaxial electrostatic spinning spray head (1).
5. a kind of building method of coaxial electrostatic spinning 3 D-printing biological support, it is characterised in that: the building method is specific
Include the following steps:
(1) spinning nozzle is connect with high pressure generator, and reception device is placed in underface, adjusts mobile station to control spinning distance；
(2) barrel temperature control device is installed outside feeding device, spray head temperature control device is installed outside spinning nozzle；
(3) coaxial electrostatic spinning silk device is fixed on bracket, is connected with external control system, and regulation and control system controls and receives
Device completes three-dimensional motion；
(4) temperature and humidity of whole device is controlled to keep the external environment of entire spinning process；
(5) high pressure generator and sampling device are opened, spinning jet is made to be in semi-cured state under the action of high-pressure electrostatic
And be constantly stacked into reception device, obtain coaxial electrostatic spinning 3 D-printing biological support.
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| CN201910183074.6A CN109853054A (en) | 2019-02-27 | 2019-02-27 | A kind of device and building method of coaxial electrostatic spinning 3 D-printing biological support |
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| CN113085174A (en) * | 2019-12-23 | 2021-07-09 | 财团法人工业技术研究院 | Electrostatic-assisted three-dimensional printing equipment |
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| CN110394985A (en) * | 2019-06-21 | 2019-11-01 | 南京大学 | A kind of devices and methods therefor constructing the three-dimensional continuous molecular self-assembling of the double-deck liquid coning row using Taylor injection effect |
| CN113085174A (en) * | 2019-12-23 | 2021-07-09 | 财团法人工业技术研究院 | Electrostatic-assisted three-dimensional printing equipment |
| CN112281303A (en) * | 2020-10-27 | 2021-01-29 | 福建师范大学 | Biological friendly medical rib fracture bandage preparation facilities |
| CN113262325A (en) * | 2021-06-10 | 2021-08-17 | 四川大学 | 3D printing customized programmed specific biological function bone tissue repair regeneration promoting scaffold material and preparation method thereof |
| CN114672889A (en) * | 2022-03-22 | 2022-06-28 | 温州大学 | Core-shell structure piezoelectric fiber force-control coaxial electrostatic spinning process |
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