CN109228325A - System and method for preparing three-dimensional multi-material multi-scale biological scaffold by adding marker bit information - Google Patents
System and method for preparing three-dimensional multi-material multi-scale biological scaffold by adding marker bit information Download PDFInfo
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- CN109228325A CN109228325A CN201811007239.6A CN201811007239A CN109228325A CN 109228325 A CN109228325 A CN 109228325A CN 201811007239 A CN201811007239 A CN 201811007239A CN 109228325 A CN109228325 A CN 109228325A
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- bit information
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/20—Apparatus for additive manufacturing; Details thereof or accessories therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/30—Auxiliary operations or equipment
- B29C64/386—Data acquisition or data processing for additive manufacturing
- B29C64/393—Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y50/00—Data acquisition or data processing for additive manufacturing
- B33Y50/02—Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Physics & Mathematics (AREA)
- Mechanical Engineering (AREA)
- Optics & Photonics (AREA)
Abstract
The invention discloses a system and a method for preparing a three-dimensional multi-material multi-scale biological scaffold by adding marker bit information. The system comprises a 3D printer, an extrusion nozzle, a marker bit information adding and processing system, a motion control card, a PC and an air pressure controller. The method breaks through an integrated preparation process control method for the multi-material multi-scale biological scaffold, so that the scaffold with different processes, materials and scales is integrally printed, the printing process is shortened, and the forming effect of the biological scaffold is improved. A user has more autonomous selectivity according to different application objects, and a potential technical scheme is provided for tissue engineering. The system has the characteristics of high automation degree, simplicity, reliability, good manufacturability, high controllability, low production cost and the like.
Description
Technical field
The present invention relates to a kind of system by the three-dimensional more multiple dimensioned biological supports of material of addition zone bit information preparation and
Method is applied to Biotechnology field.
Background technique
Increases material manufacturing technology is a kind of in recent years with the novel high-tech of huge Technology Potential, the forming principle of the technology
It is being superimposed using layer and layer, forms the entity with three-D space structure, the technology processing technology is very flexible, will not be limited
In the complicated shape of processome, the structural body of chamfered shape complexity can be processed.Due to the technology and traditional printing technique
It is similar, it is similar to traditional prints technology in two-dimensional space, therefore increases material manufacturing technology is also referred to as 3D printing technique.
Organizational project is a more popular at present cross discipline, the main contents of research be cell, biomaterial,
Growth factor and the technology and method for constructing institutional framework.Adherency and growth of the cell on tissue engineering bracket are all the time
It is the research hotspot in this field, realizes the benign growths of cell, organizational project structure is likely to clinical meaning.In recent years
Come, biological study has been increasingly turned to the research of many cells Combined culture by unicellular culture, with simulated tissue structure in human body
Interior many cells environment.
Biological 3D printing technique is sent out as medicine is to the needs of histoorgan reparation and function remodeling with multi-crossed disciplines
Exhibition is got up dedicated for the emerging technology of medical application.The technology combines the central characteristics of traditional 3D printing technique, is preparing
There is clear advantage with three-D space structure and in terms of carrying the biological supports such as medicine, and the technology personalization is very strong, it can
To prepare required a variety of different biological supports.And there is good repeatability.Therefore, the technology is in organizational project,
Organ model makes, and instructs before surgery and the fields such as medicine controlled releasing administration are got the attention.
Currently, medically histoorgan defect repair and function remodeling have become the forward position Journal of Sex Research side of cash
To.And each tissue of human body and organ are not single structures, their structure is all more complicated.For self defective tissue
Structural constituent, structure are all variant, can not medically provide which kind of material, which kind of structure or which type of drug pair now
Defective tissue is repaired most effective.Multiple dimensioned, more materials of biological 3D printing, bracket and load medicine of more gradients etc. require greatly multiple
Technique is closed to go to realize, it is comparatively laborious in technique, it takes a long time.Biological 3D printing prepares these brackets and needs using different works
Process controls bracket in print procedure, none integrated preparation process control method.Therefore, pass through
Flag bit is added to control the multiple dimensioned of biological support, more materials, more gradients are to realize that biological support integration prints important
Link allows user to have more autonomous selectivity according to different applications, provides potential technical side for organizational project
Case.
Summary of the invention
In order to solve prior art problem, it is an object of the invention to overcome deficiency existing for prior art, one kind is proposed
The system and method for three-dimensional more multiple dimensioned biological supports of material are prepared by addition zone bit information.The side that the invention is proposed
Method breaches the integration system of biological support multiple dimensioned for more materials for course control method for use, makes different process, material, scale
Bracket realize integration printing, shorten print procedure, improve the molding effect of biological support.User is allowed to be answered according to different
There are more autonomous selectivity with object, provides potential technical solution for organizational project.The system has high degree of automation,
It is simple and reliable, the features such as good manufacturability, controllability is high, and production cost is low.
To achieve the above object, the present invention adopts the following technical solutions:
A kind of system and method by the three-dimensional more multiple dimensioned biological supports of material of addition zone bit information preparation, the system
Including 3D printer, spray head, zone bit information addition and processing system, motion control card, PC and gas pressure regulator are squeezed out, it is special
Sign is that the extrusion spray head is mounted on the Z axis of 3D printer, moves up and down with the movement of 3D printer Z axis, described
Zone bit information data processing system is mounted on PC and couples motion control card, handles the zone bit information of input and is converted into
Motion control card identifies file；Motion control card connection starting controller and 3D printer, gas pressure regulator and extrusion spray head phase
Even, it squeezes out spray head and feeding system is connected by material spray head more than one group.
A method of by the three-dimensional more multiple dimensioned biological supports of material of addition zone bit information preparation, using above-mentioned one
The system that kind passes through the three-dimensional more multiple dimensioned biological supports of material of addition zone bit information preparation, comprising the following steps:
A. the biological tissue repaired as needed makes required biological support；
Threedimensional model is converted to STL model, utilizes 3D printing by the threedimensional model that bracket is b. drawn out using 3D printing
STL model with particular appearance is carried out hierarchy slicing processing by CAM software, to obtain preliminary printing path information, by this
Preliminary printing path information is converted to G code file, in order to the identification of motion control card；
C. zone bit information adding module is utilized, is first shown as the G code file containing preliminary printing path information
Printing path figure, the printing path figure and preliminary printing path graphics distinction are to remove the G0 generation for belonging to required path
Code, shows complete biological support printing path information, and the printing path can choose Three-dimensional Display in order to observe life
Object scaffold three-dimensional appearance can choose single-layer showing also in order to zone bit information addition；
D. zone bit information adding module is utilized, flag bit letter is added on complete biological support printing path figure
Breath, the layer for needing to add zone bit information is selected with mouse, then certain point on the layer first, selects to add on certain section of printing path
Machining position information or material information；
E. zone bit information processing module is utilized, the printing path for having added distinctive mark position is converted to comprising special mark
The G code of will position information, motion control card identify that common G code routing information and distinctive mark position information control three-axis platform
Movement and the material for squeezing out spray head squeeze out, to print desired specific biological support.
Compared with prior art, the present invention has following obvious prominent substantive distinguishing features and significant technological progress:
(1) addition flag bit proposed by the present invention prepares biological support and is able to achieve integrated print procedure control, thus greatly
Reduce the print time greatly, while saving printed material, simplifies last handling process.It is artificial due to not needed in print procedure
More conversion materials or manually fixed point printing, the biological support integraty of preparation is more preferable, and controllable degree is higher, repeated experiment of being more convenient for
Or modification micro-structure or parameter prepare new biological support；
(2) method that the present invention prepares biological support using addition flag bit, breaches biology multiple dimensioned for more materials
The integration system of bracket makes different process, material for course control method for use, and the bracket of scale realizes integration printing, allows use
Person has more autonomous selectivity according to different applications, provides potential technical solution for organizational project；
(3) present invention is that the G code file generated based on existing 3D printing CAM software slice inversely generates printing path figure
Shape adds zone bit information on printing path figure, regenerates the new G code file containing flag bit code, leads to the property known
Height can be identified by different motion control cards, the system is allowed to be applied to different 3D printers；
(4) present invention realizes control fixed point and carries medicine or cell printing and control empty real core fibre printing alternate, for
The raising of biological support controllability and complexity is of great significance, and provides potential technical solution for organizational project.
Detailed description of the invention
Fig. 1 is a kind of system by the three-dimensional more multiple dimensioned biological supports of material of addition zone bit information preparation of the present invention
Experimental example structure chart.
Fig. 2 is the flow chart of flag bit addition and processing system.
Fig. 3 is flag bit addition schematic diagram.
Fig. 4 is to combine material gradient biological support print procedure schematic diagram of the invention.
Fig. 5 is in conjunction with empty real core fibre alternating biological support print procedure schematic diagram of the invention.
Specific embodiment
The preferred embodiment of the present invention is described in detail now in conjunction with attached drawing.
Embodiment one:
As shown in Figure 1, this system and side by the three-dimensional more multiple dimensioned biological supports of material of addition zone bit information preparation
Method, the system include 3D printer (1), are squeezed out spray head (2), zone bit information addition and processing system (3), motion control card
(4), PC (5) and gas pressure regulator (6), it is characterised in that the extrusion spray head (2) is mounted on the Z axis of 3D printer (1),
It moves up and down with the movement of 3D printer (1) Z axis, the zone bit information data processing system (3) is mounted on PC (5) simultaneously
Couple motion control card (4), handle the zone bit information of input and is converted into motion control card (4) identification file；Motion control
Block (4) connection starting controller (6) and 3D printer (1), gas pressure regulator (6) is connected with spray head is squeezed out, and it is logical to squeeze out spray head (2)
Cross material spray head more than one group (7) connection feeding system.
Embodiment two:
The present embodiment is basically the same as the first embodiment, and is particular in that:
The zone bit information addition and processing system (3) is artificially added to the zone bit information on bracket by identification
The printing of different station or the extrusion of different spray nozzles are controlled, thus the specific biological support needed for three-dimensional space molding, it should
System allows user to have more autonomous selectivity according to different applications, provides potential technical side for organizational project
Case.
The zone bit information addition includes multiple choices: 1. multiple dimensioned: macroscopical bracket station, Electrospun, electron spray
Different station --- the addition of different station flag information；2. more materials: by means of more material spray head (7) feeding systems, realizing
Multiple material between the layers, between single layer, on single fiber different materials switching --- the addition of marking on materials information；
3. hollow, solid core fiber flag information add；4. fixed point carries medicine or cell: pinpointing setting load medicine at some or beaten in the point
Print cell.
The zone bit information that the zone bit information processing is artificially added for identification, is converted to movement for zone bit information
Control card (4) identifiable code information, motion control card (4) control (1) three axis of 3D printer according to different code informations
Movement or the control pressure controller (6) of platform (8) and control the extrusion for squeezing out spray head (2), to print specific life
Object bracket.
Embodiment three:
This system and method for preparing three-dimensional more multiple dimensioned biological supports of material by addition zone bit information, use are above-mentioned
System operatio, operating characteristics are that operating procedure is as follows:
A. the biological tissue repaired as needed makes required biological support；
Threedimensional model is converted to STL model, utilizes 3D printing by the threedimensional model that bracket is b. drawn out using 3D printing
STL model with particular appearance is carried out hierarchy slicing processing by CAM software, to obtain preliminary printing path information, by this
Preliminary printing path information is converted to G code file, in order to the identification of motion control card；
C. zone bit information adding module is utilized, is first shown as the G code file containing preliminary printing path information
Printing path figure, the printing path figure and preliminary printing path graphics distinction are to remove the G0 generation for belonging to required path
Code, shows complete biological support printing path information, and the printing path can choose Three-dimensional Display in order to observe life
Object scaffold three-dimensional appearance, or selection single-layer showing is in order to zone bit information addition；
D. zone bit information adding module is utilized, flag bit letter is added on complete biological support printing path figure
Breath, the layer for needing to add zone bit information is selected with mouse, then certain point on the layer first, selects to add on certain section of printing path
Machining position information or material information；
E. zone bit information processing module is utilized, the printing path for having added distinctive mark position is converted to comprising special mark
The G code of will position information, motion control card identify that common G code routing information and distinctive mark position information control three-axis platform
Movement and the material for squeezing out spray head squeeze out, to print desired specific biological support.
Example IV:
As shown in figures 1-4, this by the systems of the three-dimensional more multiple dimensioned biological supports of material of addition zone bit information preparation and
A kind of tissue scaffold design preparation method containing microchannel structure of method, includes the following steps:
A. it is needed to design the stent model containing microchannel structure with Three-dimensional CAD Software according to bone tissue reparation, be utilized
Biological CAM Slice Software generates preliminary routing information-G code file；
B. the G code file of generation is imported into flag bit addition and processing system, generates printing path figure, according to setting
The microchannel structure information of meter adds microchannel starting point 1 to n and end point 1 in software and arrives n, starting point and end point one
One is corresponding；
C. after having added zone bit information, the printing path for having added zone bit information is generated into the new flag bit that contains and is believed
The G code file of breath, the zone bit information contained in the G code are the enabled variable that can be identified by motion control card, movement control
Fabrication can issue squeezing for I/O signal control extrusion spray head after recognizing enabled variable when three-axis platform moves to corresponding coordinate
Out；
D. the tissue scaffold design containing microchannel structure is based on removal internal fiber hair, core material F127, shell
Material is the mixed solution of 9% gelatin and 5% sodium alginate 1:1.Squeezing out spray head is the coaxial extrusion spray head on the right side of 3D printer.
When zone bit information is identified as solid core fiber, motion control card exports low level signal, the fibre of the only shell squeezed out at this time
Dimension, when zone bit information is identified as solid core fiber, motion control card output be high level signal, at this time simultaneously squeeze out shell and
The fiber of sandwich layer.
E. after the completion of printing, the tissue scaffold design containing microchannel structure is substantially immersed in 4% calcium chloride solution,
Make it that glue connection occur with sodium alginate.After the completion of abundant glue connection, which is placed in subzero 30 degree of environment and is freezed 3 minutes,
Sandwich layer F127 Thermo-sensitive material can become liquid after taking-up, after being drawn it out with syringe, then impregnate in calcium chloride solution, make
The abundant glue connection of microchannel structure.
In the present embodiment, three-dimensional more multiple dimensioned biologies of material are prepared by addition zone bit information using this patent one kind
The system of bracket is input in motion control card using designed microchannel structure location information as zone bit information, so that
The tissue scaffold design structure can be arbitrarily devised, and printing effect can be improved using this patent, and repeatability is high.
Embodiment five:
The present embodiment is essentially identical with example IV, is particular in that:
In the present embodiment, pass through the three-dimensional more multiple dimensioned biologies of material of addition zone bit information preparation in conjunction with this patent one kind
The system of bracket, prepares bone cartilage three layers of biological support of more materials, and spray head used is that more materials of 3D printer upper left side spray
Head, the step of including, are as follows:
A. this step is identical with example IV
B. this step is identical with example IV
C. this step is identical with example IV
D. three layers of biological support of the more materials of bone cartilage have three layers of different structure, therefore each layer of material is different from.
First layer material be 1:1 mixing hydroxyapatite with the acetic acid that chitosan is dissolved in 0.5M be configured to mass concentration be 75% it is molten
Liquid；The second layer is 14% gelatin and 5% sodium alginate 1:1 mixed configuration；Third layer be sandwich layer F127,14% gelatin of shell and
5% sodium alginate 1:1 mixed solution.When recognizing the zone bit information of different materials, motion control card exports I/O signal,
Different materials is set to squeeze out printing.
E. this step is identical as example IV.
Claims (7)
1. a kind of system by the three-dimensional more multiple dimensioned biological supports of material of addition zone bit information preparation, which includes that 3D is beaten
Print machine (1) squeezes out spray head (2), zone bit information addition and processing system (3), motion control card (4), PC (5) and pressure control
Device (6), it is characterised in that the extrusion spray head (2) is mounted on the Z axis of 3D printer (1), with 3D printer (1) Z axis
Movement moves up and down, and the zone bit information data processing system (3) is mounted on PC (5) and couples motion control card (4),
It handles the zone bit information of input and is converted into motion control card (4) identification file；Motion control card (4) connection starting controller
(6) it is connected with 3D printer (1), gas pressure regulator (6) with spray head is squeezed out, squeezes out spray head (2) and pass through material spray head (7) more than one group
Connect feeding system.
2. according to claim 1 be by the three-dimensional more multiple dimensioned biological supports of material of addition zone bit information preparation
System, it is characterised in that: the zone bit information addition and processing system (3) is artificially added to the mark on bracket by identification
The printing of position information control different station or the extrusion of different spray nozzles, thus the specific biology branch needed for three-dimensional space molding
Frame, the system allow user to have more autonomous selectivity according to different applications, provide potential skill for organizational project
Art scheme.
3. according to claim 2 be by the three-dimensional more multiple dimensioned biological supports of material of addition zone bit information preparation
System, it is characterised in that: the described zone bit information addition includes multiple choices: it is 1. multiple dimensioned: macroscopical bracket station, Electrospun,
Electron spray different station --- the addition of different station flag information；2. more materials: being fed system by means of more material spray heads (7)
System, realize multiple material between the layers, between single layer, on single fiber different materials switching --- marking on materials information
Addition；3. hollow, solid core fiber flag information add；4. fixed point carries medicine or cell: some pinpoint setting carry medicine or
Cell is printed in the point.
4. according to claim 2 be by the three-dimensional more multiple dimensioned biological supports of material of addition zone bit information preparation
System, it is characterised in that: the zone bit information that the zone bit information processing is artificially added for identification converts zone bit information
For motion control card (4) identifiable code information, motion control card (4) controls 3D printer according to different code informations
(1) movement of three-axis platform (8) or control pressure controller (6) and control squeeze out spray head (2) extrusion, to print spy
Fixed biological support.
5. a kind of method by the three-dimensional more multiple dimensioned biological supports of material of addition zone bit information preparation, is wanted using according to right
It is a kind of described in asking 1 to be operated by adding the system and method that zone bit information prepares three-dimensional multi-scale biological support, it beats
Print off the complicated specific three dimensional biological bracket of multiple dimensioned, more materials, more gradients, which is characterized in that including operating step as follows
It is rapid:
A. the biological tissue repaired as needed makes required biological support；
Threedimensional model is converted to STL model by the threedimensional model that bracket is b. drawn out using 3D printing, soft using 3D printing CAM
STL model with particular appearance is carried out hierarchy slicing processing and is tentatively beaten this with obtaining preliminary printing path information by part
Print routing information is converted to G code file, in order to the identification of motion control card；
C. zone bit information adding module is utilized, is shown as printing by the G code file containing preliminary printing path information first
Graphics path, the printing path figure and preliminary printing path graphics distinction are to remove the G0 code for belonging to required path, show
Complete biological support printing path information is shown, and the printing path can choose Three-dimensional Display in order to observe biological support
Three-dimensional appearance, or selection single-layer showing is in order to zone bit information addition；
D. zone bit information adding module is utilized, adds zone bit information on complete biological support printing path figure, is used
Mouse selects to need to add the layer of zone bit information first, then certain point on the layer, selection addition work on certain section of printing path
Position information or material information；
E. zone bit information processing module is utilized, the printing path for having added distinctive mark position is converted to comprising distinctive mark position
The G code of information, motion control card identify the movement of common G code routing information and distinctive mark position information control three-axis platform
It is squeezed out with the material for squeezing out spray head, to print desired specific biological support.
6. according to claim 5 a kind of by adding the three-dimensional more multiple dimensioned biological supports of material of zone bit information preparation
Method, it is characterised in that: in stepb, the preliminary printing path information specifically includes that GO, G1 instruction and coordinate information,
Number of plies information；The printing path information is automatically generated by 3D printing CAM software slicing treatment.
7. according to claim 5 a kind of by adding the three-dimensional more multiple dimensioned biological supports of material of zone bit information preparation
Method, it is characterised in that: in step e, the distinctive mark position information of the motion control card identification is enabled variable, this makes
Energy variable can be identified by motion control card, and when motion control card identifies station zone bit information, replacement station continues printing biology
Bracket；When motion control card identification material zone bit information, I/O signal 1 is exported, controls the nozzle of different gas pressure regulator connections
Squeeze out different materials；When motion control card recognizes empty real core zone bit information, I/O signal 2 is exported, controls Coaxial nozzle sandwich layer
The printing alternate of empty real core is realized with the printing of shell；Motion control card recognizes setpoint information, exports I/O signal 3, control
The load medicine of specific gas pressure regulator connection carries cell spray head fixed point extrusion drug or cell.
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| CN201811007239.6A CN109228325A (en) | 2018-08-31 | 2018-08-31 | System and method for preparing three-dimensional multi-material multi-scale biological scaffold by adding marker bit information |
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| CN201811007239.6A CN109228325A (en) | 2018-08-31 | 2018-08-31 | System and method for preparing three-dimensional multi-material multi-scale biological scaffold by adding marker bit information |
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| US12103231B2 (en) | 2020-07-10 | 2024-10-01 | Triastek, Inc. | High-precision additive manufacturing device and high-throughput additive manufacturing system |
| US11458684B2 (en) | 2020-07-30 | 2022-10-04 | Triastek, Inc. | High-throughput and high-precision pharmaceutical additive manufacturing system |
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| CN115519788A (en) * | 2022-09-06 | 2022-12-27 | 深圳先进技术研究院 | Printing method, printing system, terminal and storage medium of tissue engineering scaffold |
| CN115519788B (en) * | 2022-09-06 | 2024-03-15 | 深圳先进技术研究院 | Printing method, printing system, terminal and storage medium for tissue engineering scaffold |
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