CN109847167A - Local anaesthesia slow releasing pharmaceutical coating bracket and conveying application system - Google Patents
Local anaesthesia slow releasing pharmaceutical coating bracket and conveying application system Download PDFInfo
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- CN109847167A CN109847167A CN201910275554.5A CN201910275554A CN109847167A CN 109847167 A CN109847167 A CN 109847167A CN 201910275554 A CN201910275554 A CN 201910275554A CN 109847167 A CN109847167 A CN 109847167A
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- sacculus
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Abstract
The present invention relates to medical instruments fields, in particular to a kind of local anaesthesia slow releasing pharmaceutical coating bracket and conveying application system；The present invention includes coating layer and for coating layer to be delivered to lumen inner close fitting in the conduit mechanism of bracket；It is uniformly distributed on coating layer and is provided with the medicament plaster layer for adhering to solid sustained release anesthetic and the particle clad for loading radion；Conduit mechanism includes the second casing of first sleeve and third casing, and running through in third casing has seal wire, and coating layer is set in first sleeve and between the second casing and third casing；In the present invention, pass through the elongation of the second casing and third casing in conduit mechanism, the coating layer of set therebetween is pulled open and is attached on bracket, anesthesia and the radion progress radiotherapy in particle clad are carried out using anesthetic is sustained on the medicament plaster layer on coating layer, without being taken out original bracket and replacing iodine particle bracket, secondary injury not will cause.
Description
Technical field
The present invention relates to medical instruments fields, apply in particular to a kind of local anaesthesia slow releasing pharmaceutical coating bracket and conveying
Patch system.
Background technique
Over range surgical discectomy is still cavity tumour (lumen cancer, cholangiocarcinoma, tumour in enteron aisle, endotracheal tumors, blood
Comedocarcinoma bolt, carcinoma of ureter etc.) unique radical-ability method.But it has occurred and that local infiltration when most of patient assessment and is far apart
The transfer of internal organs.For such patient, improves the quality of living and extend life cycle as main therapeutic purpose.Such as cavity interplantation
Enter metallic support and open Stenosis with Palliative reduction of patient clinical symptoms, the metallic support of implantation generally requires to be more than tumour
Organize both ends at least 2cm or more.Bracket physical expansion squeezes tumor tissues to tube wall.The prolonged expansion of metallic support
Some patientss are caused local discomfort symptom occur, for example the cough that trachea bracket causes patient lasting, especially night can not enter
It sleeps, seriously affects quality of life.High-order intraluminal stent causes patient serious foreign body sensation occur, and intestinal stent causes patient to occur
Serious abdominal pain, ureter bracket cause patient the serious sense of discomfort of lumbosacral region occur.Local anaesthesia drug (such as Bupivacaine/benefit
More cards) use can be substantially reduced the local discomfort of patient and improve the quality of living.I carries medicine skill by the film of proposed adoption modernization
Art, such as PGLA, nano coating, graphene etc. are used as carrier, in the outer membrane that topical remedy is carried to bracket, discharge metallic support
Afterwards, the symptoms such as related discomfort caused by stenter to implant compressing tumour are reduced by the slow release of local anaesthesia drug, due to medicine
Object is the release of localized sustained low dosage, therefore will not cause the related complications such as drug accumulation, is worth clinic further genralrlization.
In addition to this, liver cancer is also clinically common malignant tumour, and the patient of liver cancer is usually because of tumor invading portal vein
And forming portal vein tumor thrombus leads to disease rapid progression, long-dated survival is very poor.Therefore the processing of portal vein tumor thrombus is to liver cancer patient
Long-dated survival have decisive significance effect.Outer radiotherapy in the treatment portal vein tumor thrombus is clinically usually used, but due to cancer embolus wave
And range is wide, and leads to positioning radiation treatment difficulty along the distribution of curved vascular system, and since respiratory movement leads to patient's liver
Movement needs the outer radiotherapy range of exposures of expansion in turn to cause liver compared with macrolesion to cover range of tumor.Clinically appease
Property therapeutic scheme restore mainly around portal vein lumen is opened into hepatic blood flow, and then improve patients ' life quality.It needs using Jie
Enter minimally invasive puncture technique, implantation portal vein bracket opens blood vessel, but bracket is only capable of opening lumen, to tumour without therapeutic effect, companion
With the progress of tumour, the patient in 3 months more than 50% or more can occur to block generation in bracket again.Therefore there is scholar in the country
Chain structure is conspired to create using short distance radioactive particle, and 125I particle chain is pressed in outside bracket using interventional technique, passes through grain
The plesioradiotherapy control section cancer embolus of son, thus the unobstructed time of extending bracket.But since the particle chain of implantation has
Randomness, frequent particle chain, which has been implanted to non-tumour, once causes brachytherapy to fail.And clinical research shows using grain
Subchain is only capable of extending the unobstructed time of the 2-3 month.Analysis the reason is as follows that: the quantity of particle is few, causes dosage cold-zone excessive；Particle chain
Positioned at tumor tissues opposite side, in addition particle is farther apart from tumour after stent expansion, better antitumor action can not be played.Cause
On the one hand this solves the problems, such as that dosage is unevenly distributed, reduces there is an urgent need to research and develop a whole set of helical form 125I seeds implanted system
Dosage cold-zone.On the one hand, it enables to tumour to come into full contact with particle, improves brachytherapy curative effect.
Summary of the invention
To solve the above problems, the purpose of the present invention is to provide a kind of local anaesthesia slow releasing pharmaceutical coating bracket and conveying applications
The coating layer of set therebetween is pulled open by the elongation of the second casing and third casing in conduit mechanism and is attached to bracket by system
On, the radion in anesthesia and particle clad, which is carried out, using sustained release anesthetic on the medicament plaster layer on coating layer is radiated
Treatment, without being taken out original bracket and replacing I125 particle bracket, not will cause secondary injury.
The purpose of the present invention is what is be achieved through the following technical solutions:
A kind of local anaesthesia slow releasing pharmaceutical coating bracket provided by the invention and conveying application system, wherein including for being tightly attached to branch
The coating layer of frame and for the coating layer to be delivered to lumen inner close fitting in the conduit mechanism of bracket；On the coating layer uniformly
Distribution is provided with the medicament plaster layer for adhering to solid sustained release anesthetic and the particle clad for loading radion；Institute
Conduit mechanism is stated to include first sleeve, the second casing being socketed in the first sleeve and be socketed in second casing
Third casing, through there is a seal wire in the third casing, the coating layer is set in the first sleeve and in described the
Between two casings and the third casing, the coating layer is pulled open after second casing stretching and is attached to by the third casing
On bracket.
As an improvement of the present invention, gathering chamber is provided in the first sleeve, outside the lower end of second casing
It is connected with upper layer sacculus on wall, lower layer's sacculus is connected on the lower end outer wall of the third casing, the gathering chamber can collapse institute
State upper layer sacculus and lower layer's sacculus；It is provided with the first air flue in the first sleeve, is provided with first in first air flue and fills
Tracheae, the upper layer sacculus pass through first gas tube and the first inflation check valve fittings；It is set in the third casing
Be equipped with the second air flue, be provided with the second gas tube in second air flue, lower layer's sacculus by second gas tube with
Second inflation check valve fittings.
As a further improvement of the present invention, the upper layer sacculus and lower layer's sacculus are respectively provided with that there are two balloon cavities.
As a further improvement of the present invention, the upper and lower ends of the coating layer are provided with retainer ring, on the retainer ring
It is provided with the stent clamping slot for being stuck on bracket.
As a further improvement of the present invention, for storing the sustained release of sustained release anesthetic there are two being arranged on the retainer ring
Medicine cavity is anaesthetized, is provided with retainer ring permeability hole in the sustained release anesthesia medicine cavity.
As a further improvement of the present invention, two sustained release anesthesia medicine cavities are communicated by connectivity slot.
As a further improvement of the present invention, inclined-plane, the upper layer sacculus and the lower layer are provided on the retainer ring
The outer ring of sacculus is provided with the resigning groove face coincideing with the inclined-plane.
As a further improvement of the present invention, several overlay film permeability holes are provided on the medicament plaster layer.
As a further improvement of the present invention, it is provided with spiral in the first sleeve and collapses pipe, the third casing
Lower end be provided with conductor housing, lacing jacket is coaxially connected on the conductor housing, between second casing and the lacing jacket
It is cased with clamping bracket, the spiral, which collapses pipe, can entangle the clamping bracket, and the clamping bracket and the spiral collapse pipe
Between entangle the coating layer.
As a further improvement of the present invention, the first sleeve, the second casing and third casing are provided with handle
End.
In the present invention, by the elongation of the second casing and third casing in conduit mechanism, by the coating layer of set therebetween
It pulls open and is attached on bracket, carry out anesthesia and the radiation in particle clad using anesthetic is sustained on the medicament plaster layer on coating layer
Particle carries out radiotherapy and not will cause secondary injury without being taken out original bracket and replacing iodine particle bracket.
Detailed description of the invention
The drawings described herein are used to provide a further understanding of the present invention, constitutes part of this application, this hair
Bright illustrative embodiments and their description are used to explain the present invention, and are not constituted improper limitations of the present invention.In the accompanying drawings:
Fig. 1 is the structural diagram of the present invention；
Fig. 2 is front view of the invention；
Fig. 3 is that coating layer of the invention and bracket are close to structural schematic diagram one；
Fig. 4 is that coating layer of the invention and bracket are close to structural schematic diagram two；
Fig. 5 is the structural schematic diagram one of coating layer of the invention；
Fig. 6 is the structural schematic diagram one of retainer ring of the invention；
Fig. 7 is the structural schematic diagram two of retainer ring of the invention；
Fig. 8 is the structural schematic diagram two of coating layer of the invention；
Fig. 9 is the structural schematic diagram three of coating layer of the invention；
Figure 10 is the schematic diagram of internal structure one of conduit mechanism of the invention；
Figure 11 is the schematic diagram of internal structure two of conduit mechanism of the invention；
Figure 12 is the schematic diagram of internal structure three of conduit mechanism of the invention；
Figure 13 is the schematic diagram of internal structure four of conduit mechanism of the invention；
Figure 14 is the schematic diagram of internal structure five of conduit mechanism of the invention；
Figure 15 is the attachment structure schematic diagram of upper layer sacculus and retainer ring of the invention；
Figure 16 is the structural schematic diagram one of the embodiment of the present invention one；
Figure 17 is the structural schematic diagram two of the embodiment of the present invention one；
Figure 18 is the expanded schematic diagram one of the embodiment of the present invention one；
Figure 19 is the expanded schematic diagram two of the embodiment of the present invention one；
Figure 20 is the attachment structure schematic diagram of clamping bracket and bracket of the invention；
Figure 21 is the attachment structure schematic diagram one of clamping bracket of the invention；
Figure 22 is the attachment structure schematic diagram two of clamping bracket of the invention；
Figure 23 is the structural schematic diagram one for clamping bracket, coating layer and bracket of clamping bracket of the invention；
Figure 24 is the structural schematic diagram two for clamping bracket, coating layer and bracket of clamping bracket of the invention；
Figure 25 is the connection structure perspective view of the explosion for clamping bracket, coating layer and bracket of clamping bracket of the invention；
Figure 26 is the structural schematic diagram one that spiral of the invention collapses pipe；
Figure 27 is the structural schematic diagram two that spiral of the invention collapses pipe；
Figure 28 is the schematic internal view that spiral of the invention collapses pipe.
Wherein appended drawing reference are as follows: 1- coating layer, 11- medicament plaster layer, 111- overlay film permeability hole, 12- particle clad, 13-
Retainer ring, 131- stent clamping slot, 132- sustained release anesthesia medicine cavity, 133- connectivity slot, the inclined-plane 134-, 135- retainer ring permeability hole, 2- are led
Pipe mechanism, 21- first sleeve, 211- collapse chamber, the first air flue of 212-, the first gas tube of 213-, the inflation check valve of 214- first
Connector, the second air flue of 215-, the second gas tube of 216-, 217- second inflate unidirectional valve union, and 218- spiral collapses pipe, 22- the
Two casings, the upper layer 221- sacculus, 222- balloon cavity, 223- resigning groove face, 23- third casing, 231- lower layer sacculus, 24- seal wire,
25- handle end, 3- bracket.
Specific embodiment
In order to enable those skilled in the art to better understand the solution of the present invention, below in conjunction in the embodiment of the present invention
Attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is only
The embodiment of a part of the invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill people
The model that the present invention protects all should belong in member's every other embodiment obtained without making creative work
It encloses.
As shown in Fig. 1 to Figure 28, a kind of local anaesthesia slow releasing pharmaceutical coating bracket of the invention and conveying application system, including with
In the coating layer 1 for being tightly attached to bracket 3 and for coating layer 1 to be delivered to lumen inner close fitting in the conduit mechanism 2 of bracket 3.
As shown in figure 5, being uniformly distributed the medicament plaster layer being provided with for adhering to solid sustained release anesthetic on coating layer 1
11 and the particle clad 12 for loading radion.
Conduit mechanism 2 includes first sleeve 21, the second casing 22 for being socketed in first sleeve 21 and is socketed in second set
Third casing 23 in pipe 22, through there is a seal wire 24 in third casing 23, coating layer 1 is set in first sleeve 21 and in the
Between two casings 22 and third casing 23, coating layer 1 is pulled open after the stretching of the second casing 22 and is attached to bracket 3 by third casing 23
On.
In the present invention, by the elongation of the second casing 22 and third casing 23 in conduit mechanism 2, by set covering therebetween
Film layer 1, which is pulled open, to be attached on bracket 3, carries out anesthesia and particle storehouse using anesthetic is sustained on the medicament plaster layer 11 on coating layer 1
Radion in layer 12 carries out radiotherapy not will cause without being taken out original bracket and replacing I125 particle bracket
Secondary injury.
Bracket 3 is to be originally present in patient's lumen wall to play channeling, and 3 structure of bracket uses Weaving type, the volume of bracket 3
Type silk screen is knitted to be made of Nitinol material.There is coating layer 1 with what 3 length of bracket and circumference were coincide, coating layer 1 is cylindrical shape
It opens and is close on the inside of Shi Keyu bracket 3, coating layer 1 is that macromolecule flexible material is formed.The circle on the coating layer 1 of 3 mesh of bracket
Weekly interval is provided with medicament plaster layer 11 and particle clad 12.Medicament plaster layer 11 and particle clad 12 are in 3 mesh of bracket
Along bracket outer wall, axially several peripheral helicals are uniformly distributed overlay film.The I125 grain of bar shaped is mounted with inside particle clad 12
Son is attached with solid sustained release anesthetic inside medicament plaster layer 11, and sustained release anesthetic is in round pie, can make surface most
Limits are fitted on patient's wall of the lumen and are anaesthetized.Particle clad 12 is uniform using single spiral spiral at 3 mesh of bracket
Distribution, this can be designed so that the drug of bracket overlay film and I125 particle can be with circumference integrally to the tumor locus of lumen area
It carries out radiotherapy and drug assists in the treatment of；And several overlay film infiltrations is provided in 11 outer layer of medicament plaster layer of coating layer 1
Hole 111, overlay film permeability hole 111 facilitate the infiltration to drug, so that the drug therapy of more convenient pair of lumen area tumour is made
With.
As shown in Fig. 3, Fig. 6 and Fig. 7, the upper and lower ends of coating layer 1 are provided with retainer ring 13, are provided with and are used on retainer ring 13
The stent clamping slot 131 being stuck on bracket 3；For storing the sustained release anesthesia medicine cavity of sustained release anesthetic there are two being arranged on retainer ring 13
132, sustained release anaesthetizes and is provided with retainer ring permeability hole 135 in medicine cavity 132；Two sustained release anesthesia medicine cavities 132 pass through 133 phase of connectivity slot
It is logical；Several overlay film permeability holes 111 are provided on medicament plaster layer 11；In particular, in the 1 upper and lower side port of coating layer of tubular
It is connected with the retainer ring 13 of annular, retainer ring 13 is made of the medical macromolecular materials with elastic deformation characteristic.Retainer ring 13 is towards branch
Circumference is provided with the stent clamping slot 131 of annular in the corresponding end surface of 3 upper and lower end face of frame, and stent clamping slot 131 is towards on bracket 3
Lower end surface is provided with gap towards face circumference, and it is more than half-circle area and the volume with bracket 3 that stent clamping slot 131, which clamps section,
Knitmesh silk thickness is coincide, and is allowed stent clamping slot 131 to carry out clamping to the bracket twine of 3 upper and lower port of bracket, is worked as overlay film
The retainer ring 13 of 1 upper and lower side of layer can make the tension of coating layer 1 it to be close to together in 3 inside of bracket to after 3 upper and lower port clamping of bracket
Wall；As shown in Figure 6 and Figure 7, the stent clamping slot 131 inside retainer ring 13 in the outer part at upper skew angle respectively design have ring
The cavity of shape is sustained release anesthesia medicine cavity 132, and sustained release is anaesthetized equipped with sustained release arcotic inside medicine cavity 132, in two annular sustained releases
It anaesthetizes even circumferential on the lateral wall of medicine cavity 132 and is provided with several retainer ring permeability holes 135, retainer ring permeability hole 135 can make internal delay
Arcotic is released to penetrate to patient's wall of the lumen to play anaesthetic effect.Two sustained releases fiber crops in the inner and outer side wall in 13 oblique angle of retainer ring
It is provided with interval between liquor-saturated medicine cavity 135, and even circumferential is provided with several connectivity slots 133 on septal surface, convenient for two sustained release fiber crops
Liquor-saturated 132 interior liquid of medicine cavity sustained release anesthetic liquid medicine can interpenetrate connection, prevent wherein a chamber medical fluid is dry can not be to lumen
Wall is anaesthetized.
As shown in FIG. 10 to 14, it is provided in first sleeve 21 and collapses chamber 211, connected on the lower end outer wall of the second casing 22
It is connected to upper layer sacculus 221, lower layer's sacculus 231 is connected on the lower end outer wall of third casing 23, upper layer ball can be collapsed by collapsing chamber 211
Capsule 221 and lower layer's sacculus 231；It is provided with the first air flue 212 in first sleeve 21, is provided with the first inflation in the first air flue 212
Pipe 213, upper layer sacculus 221 are connected to by the first gas tube 213 with the first unidirectional valve union 214 of inflation；It is set in third casing 21
It is equipped with the second air flue 215, the second gas tube 216 is provided in the second air flue 215, lower layer's sacculus 231 passes through the second gas tube 216
It is connected to the second unidirectional valve union 217 of inflation；As shown in Figure 10 and Figure 15, upper layer sacculus 221 is provided with lower layer sacculus 231
Two balloon cavities 222；In particular, 2 outermost layer of conduit mechanism is first sleeve 21,21 lower end surface of first sleeve is axially upward
It is provided with the gathering chamber 211 of certain depth blind hole, is collapsed inside chamber 211 convenient for gathering upper layer sacculus 221 and lower layer's sacculus 231.
The handle end 25 of "-" type is fixedly installed on 21 upper end end point outer wall of first sleeve, handle end 25 pushes away convenient for hand-held control
It draws and anti-rotation acts on.The second casing 22,22 upper end end of the second casing are socketed at through hole at the axle center of first sleeve 21
It is provided with handle end 25 identical with first sleeve 21 on head outer wall, is provided on outer wall at 22 lower end port of the second casing
Layer sacculus 221, the expansion of upper layer sacculus 221 are round pie when full, are provided with wall at 221 bosom height of upper layer sacculus
It is set to be divided into two balloon cavities 222, respectively two chamber of one chamber of upper layer sacculus and upper layer sacculus.Two are set as by wall
The purpose of chamber is can be by the support of wall, so that outer ring middle position of the upper layer sacculus 221 after full has one
Fixed intensity will not be easy depressed deformation as other regions of upper layer sacculus 221 after pressing.In the interior of first sleeve 21
It is provided with the first air flue 212 along axial direction, 212 lower end of the first air flue is respectively arranged with venthole in one chamber of upper layer sacculus and two chambers,
21 the first air flue of upper end of first sleeve is connected with the first gas tube 213 at 212 port, connects in 213 end point of the first gas tube
There is the unidirectional valve union 214 of the first inflation, it can be to 221 two chambers in inside of upper layer air bag by the first unidirectional valve union 214 of inflation
It synchronizes and is inflated.It is socketed with third casing 23 inside the second casing 22, it is same on 23 upper end end side wall of third casing
It is provided with "-" type handle end 25,23 lower end end outer wall of third casing is provided with lower layer's sacculus 231,231 knot of lower layer's sacculus
Structure is identical as upper layer sacculus 221, and lower layer's sacculus 231 is same to be divided into two chambers by intermediate wall, and works as lower layer's sacculus 231
Outer ring circumference resigning groove face 223 can be equally stuck at 13 inclined-plane 134 of retainer ring of lower section after expansion is full.21 lower end of first sleeve
Gathering chamber 211 have certain length can be by upper layer sacculus 221,1 dependency structure of coating layer, lower layer's sacculus 231 successively revenue and expenditure
Wherein.The second air flue 215 is axially provided with inside 23 tube wall of third casing, the second air flue 215 is in 231 two chambers of lower layer's sacculus
Tube wall at be provided with aperture as venthole, be connected with the second gas tube 216 in the upper end of third casing 23 and the second inflation be single
To valve union 217 for being inflated to lower layer's sacculus 231.Through there is seal wire 24 inside at 23 axle center of third casing, it is used for
Guiding function is played when conduit promotes in vivo.
In the present invention, it is provided with inclined-plane 134 on retainer ring 13, upper layer sacculus 221 and the outer ring of lower layer sacculus 231 are provided with
The resigning groove face 223 coincideing with inclined-plane 134；In particular, being set as oblique in the end plane angle separate with 3 port of bracket of retainer ring 13
Face 134, and the long inside in outside is short so that inclined-plane 134 is that outside tilts inwardly.On upper layer 221 circumference outer ring of sacculus be designed as with
The identical resigning groove face 223 in 13 inclined-plane 134 of retainer ring so that upper layer sacculus 221 retainer ring 13 be fitted into after full it is swollen
Tight clamping, and the wall of upper layer sacculus 223 is sitting at circumferential groove face height can play firm effect to retainer ring.
When needing to I125 particle radiation therapy is carried out at patient's lumen internal stent 3, original state first sleeve
21, the second casing 22, third casing 23, seal wire 25 are successively inserted in, while 21 lower section of first sleeve is collapsed what intracavitary portion was collapsed
1 dependency structure of coating layer is inserted between upper layer sacculus 221 and lower layer's sacculus 231, is delivered to patient support 3 to conduit mechanism 2
When setting, it is pulled upwardly first sleeve 21 and second casing 22 and the lower end of third casing 23 can be exposed.First filled to second
The unidirectional valve union 217 of gas is inflated, and gas enters to lower layer's sacculus by the second air flue 215 inside 23 tube wall of third casing
231 keep its expansion full, and lower layer's sacculus 231 drives the lower section support of retainer ring 13 to circumferential shapes, and by the stent clamping slot of retainer ring 13
131 are clamped at the port of bracket 3.When 13 clamping 3 lower end of bracket of retainer ring of lower section, by above-mentioned same operation by top
The inflation of upper layer sacculus 221 is full and the retainer ring of top 13 is clamped at the port of 3 upper end of bracket, in 13 clamping fixed of retainer ring
It is should be noted in the process by the mesh grid mesh of the particle storehouse 12 of coating layer 1 bracket 3 corresponding with medicament plaster layer 11, so that particle
Clad 12 and medicament plaster layer 11 can contact wall of the lumen tissue to carry out particle radiation therapy and anesthesia to its Tumors
Slow release effect.Coating layer 1 can be tightly attached to rack inner wall after the equal clamping fixed of upper and lower retainer ring 13, and opposite snap-fit makes up and down
Total is fixed more firm.The sustained release anesthesia medicine cavity 132 of upper and lower retainer ring 13 can be right always while clamping consolidates
Patient's wall of the lumen discharges anesthetic liquid medicine, and solid sustained release anesthetic in the medicament plaster layer 11 of coating layer 1 is cooperated to cooperate particle storehouse
I125 treats tumour in layer 12.
The local anaesthesia slow releasing pharmaceutical coating bracket and conveying application system, have the advantages that
1, coating layer 1 is detached from 3 individualism of bracket, so that no replacement is required that bracket 3 can pass through coating layer 1 and original bracket by patient
3, which keep relatively fixed, treats tumour at lumen wall, and causing in the process to patient so as to avoid replacement bracket 3 need not
The increase of the injury and expenses of surgical treatment wanted；This design simultaneously is but also coating layer 1 can be convenient for changing or withdraw from
Subsequent procedures operation provides great convenience.Several spiral-distributed particle clads 12 that even circumferential is distributed on coating layer 1
The medicament plaster layer 11 for having several overlay film permeability holes 111 with design can load I125 particle and sustained release anaesthetic to tumour
It is treated.
2, the stent clamping slot 131 that the retainer ring 13 of 1 upper and lower side of coating layer connection is arranged facilitates to the upper and lower port of bracket 3
Clamping is carried out so that coating layer 1 can not be loosened with the opposite clamping fixed of bracket 3, retainer ring 13 in the outer part design by upper and lower position
Two interconnected sustained release anesthesia medicine cavities 132 anaesthetize the sustained release inside medicine cavity by the retainer ring permeability hole 135 of lateral wall
Medicament it is continual and steady sustained release anesthetic effect is played to lumen wall.
3, upper layer sacculus 221 and lower layer's sacculus after the design cooperation of inclined-plane 134 at 13 port of upper and lower two retainer rings fills
The resigning groove face 223 of 231 intermediate outer ring circumference is fitted into clamping and can strut retainer ring 13, is clamped in 3 port of bracket convenient for retainer ring 13
Place.Being by the purpose that wall is set as two chambers can be by the support of wall, so that upper layer sacculus 221 is full
Outer ring middle position afterwards has certain intensity, depressed deformation will not be easy after pressing as other regions of upper layer sacculus 231.
In the present invention, as shown in Figure 15 to Figure 28, the present invention provides one embodiment one, in the embodiment one, the
It is provided with spiral in sleeve 21 and collapses pipe 218, the lower end of third casing 23 is provided with conductor housing 232, coaxial on conductor housing 232
It is connected with lacing jacket 233, is cased between the second casing 22 and lacing jacket 233 and clamps bracket 224, spiral collapses pipe 218 and can entangle
Bracket 224 is clamped, bracket 224 is clamped and spiral collapses and entangles coating layer 1 between pipe 218；First sleeve 21, the second casing 22 with
Third casing 23 is provided with handle end 25；It is successively cased in particular, conduit mechanism 2 is similarly first sleeve 21 from outside to inside
Second casing 22 and third casing 23, a word of first sleeve 21, the second casing 22 and the setting of 23 rear manipulatable end of third casing
Type handle end 25 is consistent with conduit mechanism 2 above-mentioned.The gathering chamber 211 of 21 lower end of first sleeve is internally provided with spiral gathering
Pipe 218, spiral collapse that pipe 218 is generally cylindric, and collapsing 218 inner wall of pipe in spiral is the distribution of several even circumferentials to axis
Direction spiral ridge wire type angular shape.The spiral collapses 218 length of pipe and is longer than in the elongated clamping bracket 224 for tightening state, makes
Bracket 224, which must be clamped, can be received completely to spiral gathering pipe 218.The second casing 22 being nested with inside first sleeve 21
Inner wall to inside certain depth region is designed as step-like structure at front-end port, so that at 22 front-end port of the second casing
The wall thickness of wall is less than remaining position.Third casing 23 is cased with inside the second casing 22,23 leading portion of third casing can be extended out
Two casings 22 simultaneously extend certain distance, and the conductor housing 232 of cone is fixedly and coaxially connected at 23 front-end port of third casing,
It is coaxially fixed with lacing jacket 233 in 232 rear end face of conductor housing, whole lacing jacket 233 is in sleeve-shaped, and 233 gap of lacing jacket is matched
For trap on third casing 23, inner wall and 23 tube wall of third casing have spacing.It is placed on 22 leading portion of the second casing of third casing 23
It is cased between 23 tube wall of inner wall and third casing of lacing jacket 233 and clamps bracket 224, clamped 224 length of bracket and be longer than bracket
3.Second casing, 22 front end and lacing jacket 233 are tightened respectively in the both ends for clamping bracket 224, when first sleeve 21 pushes forward top
When to conductor housing 232, the spiral of 21 front end of first sleeve, which collapses pipe 218, can be placed on the outside for clamping bracket 224.When spiral collapses
When the recession of pipe 218 will clamp 224 sections of exposings of bracket, increased by the handle end of hand-held the second casing of control 22 and third casing 23
Relative distance between second casing 22 and lacing jacket 233 can will clamp bracket 224 and discharge.Clamping bracket 224 and spiral
It collapses and is cased with coating layer 1 between pipe 218, the coating layer 1 of the embodiment one is consistent with 1 structure of coating layer above-mentioned seldom to be repeated.
In the embodiment one, original state will first clamp bracket 224 and be pulled to elongated and collar be distinguished in second in both ends
Inside 22 leading portion of casing and 232 rear end lacing jacket of conductor housing, clamping 224 periphery of bracket is wrapped in by 1 set of coating layer, and by first set
Pipe 21 push forward so that clamp bracket 224 and coating layer 1 collapses in be placed on inside spiral gathering pipe 218.Spiral collapses pipe
Several even circumferentials distribution of 218 inner walls can prevent coating layer 1 and clamping bracket to axis direction spiral ridge wire type wedge angle
Situations such as 224 generation Relative slidings even slip occurs, when first sleeve 21 relative to the second casing 22 and third casing 23 to
When drive spiral gathering pipe 218 being pulled gradually to discharge coating layer 1 and clamping bracket 224 afterwards, it can be collapsed always by spiral
The spiral ridge wire type wedge angle of 218 inner wall of pipe plays firm effect, Neng Gou to the coating layer 1 and clamping bracket 224 of non-releasing section
To be able to maintain the two always relatively fixed with bracket 224 is clamped before completely disengaging spiral and collapsing pipe 218 for coating layer 1.
After spiral collapses pipe 218, and 21 post-tensioning of first sleeve is followed to discharge lacing jacket completely and clamp bracket 224, the second casing 22 is only remained
Front end step section and the both ends of 233 pairs of clamping brackets 224 of lacing jacket are tightened, and are pulled back while pushing the second casing 22 forward
Third casing 23 so that the second casing 22 becomes smaller with 233 relative distance of lacing jacket, 22 step section end face of the second casing with tighten
It covers and makes to clamp 224 interlude expansion upheaval of bracket under the thrusting action of 233 nose catheter head, 232 rear end face, to clamp branch
Thick shape between the detail of both ends is integrally formed in frame 223, and the interlude for clamping bracket 224 props up the support of coating layer 1 to inside lumen
Frame 3 is close to.After the relative position of coating layer 1 and bracket 3 determines errorless, third casing 23, third casing 23 are pushed forward
It drives lacing jacket 233 to push forward so that the front-end port for clamping bracket 224 progressively disengages and tightens 233 sets, finally clamps bracket
224 front end discharges completely shores on lumen wall to clamp bracket 224 and wall of the lumen is relatively fixed.It pulls back at this time
Second casing 22, the other end that release clamps bracket 224 shore the clamping completion of bracket 224 to lumen wall, coating layer 1
It is fixedly clamped completely between bracket 3 and clamping bracket 224, so that the solid-state sustained release anaesthetic of 1 round pie of coating layer is matched
I125 particle is closed to treat the tumour of lumen wall.
The embodiment one has following advantage:
1, coating layer 1 is clamped in bracket 3 and clamped between bracket 224 by the clamping bracket 224 for being longer than bracket 3 using length, is made
Coating layer 1 is completely fixed to carry out radiotherapy to lumen wall, such mode can according to the length of original bracket 3 with
Specification arbitrarily replaces corresponding clamping bracket, treats with universal convenient for doctor, Conventional coverlay film formula bracket abutting occurs
In causing medicament because the insufficient or overlay film frame of the too short treatment of length overlay film frame is too long on original bracket vacantly and can not be bonded
It is unable to fully treat to lumen wall.
2, the step section of the second casing 22 and lacing jacket 233, which are tightened, clamps 224 both ends of bracket, and spiral collapses 218 pairs of pipe folders
The interlude of locking bracket 224 collapse and is tightened, and clamping bracket 224 is tightened completely, and spiral collapses 218 inner wall of pipe
Spiral ridge wire type wedge angle to the coating layer of non-releasing section and clamp bracket 224 and play firm effect, can be in coating layer 1 and folder
It is relatively fixed that locking bracket 224 is able to maintain the two before completely disengaging spiral and collapsing pipe 218 always, convenient for clamping bracket
224 control coating layers 1 conform to 3 accurate location of bracket, behind 22 step section end face of the second casing and 233 nose catheter head of lacing jacket
Play thrusting action in end face.
3, using control 224 interlude expansion upheaval of bracket can be clamped in release, to clamp the whole shape of bracket 224
At shape thick between the detail of both ends, the support of coating layer 1 is extremely close to lumen internal stent 3 by the interlude for clamping bracket 224, so that
Coating layer 1 is close to subsequent release complete again behind centering position, has very high serious forgiveness, avoids the occurrence of as conventional stent release side
Formula directly tightens state release by elongated, and position can not slide after there is deviation.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of local anaesthesia slow releasing pharmaceutical coating bracket and conveying application system, which is characterized in that including for being tightly attached to bracket
Coating layer and for the coating layer to be delivered to lumen inner close fitting in the conduit mechanism of bracket；It is uniformly distributed on the coating layer
It is provided with the medicament plaster layer for adhering to solid sustained release anesthetic and the particle clad for loading radion；It is described to lead
Pipe mechanism includes first sleeve, the second casing being socketed in the first sleeve and the third being socketed in second casing
Casing, the third casing is interior through there is seal wire, and the coating layer is set in the first sleeve and in described second set
Between pipe and the third casing, the coating layer is pulled open after second casing stretching and is attached to bracket by the third casing
On.
2. a kind of local anaesthesia slow releasing pharmaceutical coating bracket according to claim 1 and conveying application system, which is characterized in that institute
It states and is provided with gathering chamber in first sleeve, upper layer sacculus, the third casing are connected on the lower end outer wall of second casing
Lower end outer wall on be connected with lower layer's sacculus, the gathering chamber can collapse the upper layer sacculus and lower layer's sacculus；The first set
It is provided with the first air flue in pipe, the first gas tube is provided in first air flue, the upper layer sacculus is filled by described first
Tracheae and the first inflation check valve fittings；The second air flue, setting in second air flue are provided in the third casing
There is the second gas tube, lower layer's sacculus passes through second gas tube and the second inflation check valve fittings.
3. a kind of local anaesthesia slow releasing pharmaceutical coating bracket according to claim 2 and conveying application system, which is characterized in that institute
It states upper layer sacculus and lower layer's sacculus is respectively provided with that there are two balloon cavities.
4. a kind of local anaesthesia slow releasing pharmaceutical coating bracket according to claim 3 and conveying application system, which is characterized in that institute
The upper and lower ends for stating coating layer are provided with retainer ring, and the stent clamping slot for being stuck on bracket is provided on the retainer ring.
5. a kind of local anaesthesia slow releasing pharmaceutical coating bracket according to claim 4 and conveying application system, which is characterized in that institute
It states and is arranged on retainer ring there are two for storing the sustained release anesthesia medicine cavity for being sustained anesthetic, be provided with card in the sustained release anesthesia medicine cavity
Enclose permeability hole.
6. a kind of local anaesthesia slow releasing pharmaceutical coating bracket according to claim 5 and conveying application system, which is characterized in that two
A sustained release anesthesia medicine cavity is communicated by connectivity slot.
7. a kind of local anaesthesia slow releasing pharmaceutical coating bracket according to claim 6 and conveying application system, which is characterized in that institute
It states and is provided with inclined-plane on retainer ring, the outer ring of the upper layer sacculus and lower layer's sacculus is provided with the resigning coincideing with the inclined-plane
Groove face.
8. a kind of local anaesthesia slow releasing pharmaceutical coating bracket according to claim 7 and conveying application system, which is characterized in that institute
It states and is provided with several overlay film permeability holes on medicament plaster layer.
9. a kind of local anaesthesia slow releasing pharmaceutical coating bracket according to claim 1 and conveying application system, which is characterized in that institute
It states and is provided with spiral in first sleeve and collapses pipe, the lower end of the third casing is provided with conductor housing, coaxial on the conductor housing
It is connected with lacing jacket, clamping bracket is cased between second casing and the lacing jacket, the spiral, which collapses pipe, can cover residence
Clamping bracket is stated, the clamping bracket and the spiral collapse and entangle the coating layer between pipe.
10. a kind of local anaesthesia slow releasing pharmaceutical coating bracket according to claim 1 and conveying application system, which is characterized in that
The first sleeve, the second casing and third casing are provided with handle end.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910275554.5A CN109847167B (en) | 2019-04-08 | 2019-04-08 | Local anesthesia slow-release drug coating stent and conveying application system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910275554.5A CN109847167B (en) | 2019-04-08 | 2019-04-08 | Local anesthesia slow-release drug coating stent and conveying application system |
Publications (2)
| Publication Number | Publication Date |
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| CN109847167A true CN109847167A (en) | 2019-06-07 |
| CN109847167B CN109847167B (en) | 2023-03-31 |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030032851A1 (en) * | 2001-07-13 | 2003-02-13 | Apple Marc G. | Catheter with concentric balloons for radiogas delivery and booster radiosources for use therewith |
| US20050209674A1 (en) * | 2003-09-05 | 2005-09-22 | Kutscher Tuvia D | Balloon assembly (V) |
| US20100070015A1 (en) * | 2008-09-10 | 2010-03-18 | Ev3 Inc. | Stents and catheters having improved stent deployment |
| CN104174110A (en) * | 2013-05-23 | 2014-12-03 | 微创心脉医疗科技（上海）有限公司 | Medicine balloon and preparation method thereof |
| CN105997314A (en) * | 2016-06-30 | 2016-10-12 | 魏诗荣 | Thrombus removing system with compound function |
| CN106983950A (en) * | 2017-04-12 | 2017-07-28 | 牛洪欣 | Rechargeable type particle conduit |
-
2019
- 2019-04-08 CN CN201910275554.5A patent/CN109847167B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030032851A1 (en) * | 2001-07-13 | 2003-02-13 | Apple Marc G. | Catheter with concentric balloons for radiogas delivery and booster radiosources for use therewith |
| US20050209674A1 (en) * | 2003-09-05 | 2005-09-22 | Kutscher Tuvia D | Balloon assembly (V) |
| US20100070015A1 (en) * | 2008-09-10 | 2010-03-18 | Ev3 Inc. | Stents and catheters having improved stent deployment |
| CN104174110A (en) * | 2013-05-23 | 2014-12-03 | 微创心脉医疗科技（上海）有限公司 | Medicine balloon and preparation method thereof |
| CN105997314A (en) * | 2016-06-30 | 2016-10-12 | 魏诗荣 | Thrombus removing system with compound function |
| CN106983950A (en) * | 2017-04-12 | 2017-07-28 | 牛洪欣 | Rechargeable type particle conduit |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109847167B (en) | 2023-03-31 |
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