CN109846494A - Fixing piece and sensing system for implanted analyte sensor - Google Patents
Fixing piece and sensing system for implanted analyte sensor Download PDFInfo
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- CN109846494A CN109846494A CN201811348478.8A CN201811348478A CN109846494A CN 109846494 A CN109846494 A CN 109846494A CN 201811348478 A CN201811348478 A CN 201811348478A CN 109846494 A CN109846494 A CN 109846494A
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- receiving portion
- fixing piece
- conductive path
- analyte sensor
- sensor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6879—Means for maintaining contact with the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6879—Means for maintaining contact with the body
- A61B5/6882—Anchoring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/22—Arrangements of medical sensors with cables or leads; Connectors or couplings specifically adapted for medical sensors
- A61B2562/225—Connectors or couplings
- A61B2562/227—Sensors with electrical connectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring pH
Abstract
The present invention provides a kind of fixing piece for implanted analyte sensor, and for the sensor with double-sided microelectrodes, the fixing piece includes support portion, receiving portion, conductive path and through hole；Receiving portion is made of receiving portion top, receiving portion side wall, receiving portion bottom and receiving portion inner wall, and support portion is connected to receiving portion bottom and forms receiving portion bottom platform；Through hole is located on support portion, open at one end in receiving portion bottom platform；Conductive path is located in receiving portion；The conductive path includes at least two ends.The present invention also provides the implanted analyte sensing systems including fixing piece.The invention has the benefit that the fixing piece makes double-sided microelectrodes sensor prepare difficulty relative reduction, cost can effectively reduce.In addition the anchor structure is simple, and manufacture craft is low, and the replacement of sensor is simple and convenient.
Description
Technical field
The present invention relates to the fixing pieces for implanted analyte sensor and the implanted analyte including the fixing piece
Sensing system belongs to technical field of electroanalytical chemistry detection.
Background technique
For previous analyte detection technique, by taking the patient with diabetes as an example, they need periodic detection blood
In glucose content, then to puncture skin by puncture needle, utilize colorimetric method, electrochemical methods or optics after acquiring blood
Detection method is detected.These methods are not only cumbersome but also also increase the burden of patient.Therefore, in order to solve asking above
Topic, and for the needs continuously detected are changed to analyte concentration in vivo, many is for continuously analyzing the dress of analyte detection
It sets and is developed.
In the prior art, the method for electrochemical analysis is generally used.For this purpose, the sensor for testing and analyzing object is at least
Equipped with working electrode, to electrode and reference electrode.These electrodes are typically in the same side, or are distributed in opposite two sides.Such as
The patent of Publication No. CN102665549B, CN104887242A, CN103750819B are disclosed distribution of electrodes in sensor
The method of the same side, this distribution mode needs are distributed a variety of electrodes in limited area, undoubtedly increase technology difficulty with
And technical requirements.And as the patent of Publication No. CN102469964B, US9795326B2 is disclosed distribution of electrodes in sensor
The method of two sides, can reduce the technology difficulty of sensor production in this way, but fix the fixing piece of the sensor
It needs that electric contact is arranged on different sides, therefore increases the complexity of fixing piece or the difficulty of sensor is installed.
Summary of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of fixations for implanted analyte sensor
Part, especially suitable for the sensor with double-sided microelectrodes, basic ideas of the invention are towards microelectrode (opposite electrode)
Side first end is set, the interface of the first end and opposite electrode is electrically connected.At the same time, the second end and first
End is electrically connected, and the second end interface corresponding with sensor current data generating device is connected, so that sensor
Current data generating device can connect the sensor microelectrode with two-sided structure, to carry out analyte testing.
The purpose of the present invention is to provide a kind of fixing pieces for implanted analyte sensor, two-sided micro- for having
The sensor of electrode, the fixing piece include support portion, receiving portion, conductive path and through hole；Receiving portion by the top of receiving portion,
Receiving portion side wall, receiving portion bottom and receiving portion inner wall are constituted, and it is flat that support portion is connected to receiving portion bottom formation receiving portion bottom
Platform；Through hole is located on support portion, open at one end in receiving portion bottom platform；Conductive path is located in receiving portion；The conduction
Access includes at least two ends.
In some preferred embodiments, the conductive path includes first end and the second end, the second end and
One end is electrically connected.
In some preferred embodiments, conductive path runs through receiving portion.
In some preferred embodiments, conductive path is located at receiving portion outer surface.
In some preferred embodiments, conductive path a part runs through receiving portion, and another part is located at receiving portion appearance
Face.
In some preferred embodiments, receiving portion has the conductive vias for accommodating conductive path.
In some preferred embodiments, first end is located at receiving portion inner wall, the second end be located at the top of receiving portion or
Side wall.
In some preferred embodiments, conductive path further includes the third end in receiving portion；Third end with
The second end and first end are electrically connected.
In some preferred embodiments, described accommodation section is equipped with one to three groove；Groove is located in receiving portion
Wall or bottom.
In some preferred embodiments, the fixing piece also wraps the conductive sheet being located in receiving portion；The conductive sheet with
The end of conductive path is electrically connected.
It further include sealing ring in some preferred embodiments, sealing ring is surrounded on support portion side wall.
It further include interconnecting piece in some preferred embodiments, interconnecting piece is connected on support portion.
On the other hand, the present invention also provides a kind of implanted analyte sensor systems, including detection unit, signal to transmit
Device, data processing unit；
Detection unit and signal transmitting apparatus are fixed in a shell, and a power supply is additionally provided in the shell, are used
It powers in for the electronic component in shell；
Detection unit includes implanted analyte sensor, of the invention for fixing consolidating for implanted analyte sensor
Determine part and sensor current data generating device.
Specifically, fixing piece includes support portion, receiving portion, conductive path and through hole；Receiving portion is by receiving portion top, appearance
Receiving portion's side wall, receiving portion bottom and receiving portion inner wall is constituted, and support portion is connected to receiving portion bottom and forms receiving portion bottom platform；
Through hole is located on support portion, open at one end in receiving portion bottom platform；Conductive path is located in receiving portion；The conductive path
Including at least two ends.
In some preferred embodiments, fixing piece is fixed on outer casing base by the interconnecting piece being connected on support portion
On.
In some preferred embodiments, the conductive path includes first end and the second end, the second end and
One end is electrically connected.
In some preferred embodiments, conductive path runs through receiving portion.
In some preferred embodiments, conductive path is located at receiving portion outer surface.
In some preferred embodiments, conductive path a part runs through receiving portion, and another part is located at receiving portion appearance
Face.
In some preferred embodiments, receiving portion has the conductive vias for accommodating conductive path.
In some preferred embodiments, first end is located at receiving portion inner wall, the second end be located at the top of receiving portion or
Side wall.
In some preferred embodiments, conductive path further includes the third end in receiving portion；Third end with
The second end and first end are electrically connected.
In some preferred embodiments, described accommodation section is equipped with one to three groove；Groove is located in receiving portion
Wall or bottom.
In some preferred embodiments, the fixing piece also wraps the conductive sheet being located in receiving portion；The conductive sheet with
The end of conductive path is electrically connected.
The invention has the benefit that the fixing piece makes double-sided microelectrodes sensor prepare difficulty relative reduction, it can be effective
Reduce cost.In addition the anchor structure is simple, and manufacture craft is low, and the replacement of sensor is simple and convenient.Also, it is fixed with this
The implanted analyte sensor system detection efficiency of part improves.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of sensor tow sides；
Fig. 2-1, Fig. 2-1 and Fig. 2-3 are the schematic top plan view of the fixing piece of different structure；
Fig. 3-1 is fixing piece front schematic view: where Fig. 3-1a is conductive vias schematic diagram, and Fig. 3-1b is conductive path
Schematic diagram, Fig. 3-1c are conductive sheet schematic diagram；
Fig. 3-2 is fixing piece schematic rear view: where Fig. 3-2a is conductive vias schematic diagram, and Fig. 3-2b is conductive path
Schematic diagram, Fig. 3-2c are conductive sheet schematic diagram；
Fig. 3-3 (Fig. 3-3a and 3-3b) is that the schematic diagram after sensor is inserted on fixing piece；
Conductive path runs through the schematic layout pattern of receiving portion in Fig. 3-4 (Fig. 3-4a and 3-4b) fixing piece；
Schematic diagram of Fig. 4-1 (Fig. 4-1a and 4-1b) conductive path in receiving portion outer surface；
Another schematic diagram of Fig. 4-2 (Fig. 4-2a, 4-2b and 4-2c) conductive path in receiving portion outer surface；
Another schematic diagram after sensor is inserted on Fig. 4-3 (Fig. 4-3a and 4-3b) fixing piece；
Another schematic diagram of Fig. 4-4 (Fig. 4-4a, 4-4b and 4-4c) conductive path in receiving portion outer surface；
Receiving portion is run through in Fig. 5 conductive path part, is partially located at the schematic top plan view on receiving portion surface；
Fig. 6 is implanted analyte sensing system schematic diagram.
Specific embodiment
Following embodiment further illustrates the present invention.These embodiments are not intended to limit the scope of the invention, and are to provide
A further understanding of the present invention.
A kind of implanted analyte sensor system (can be used in continuing to monitor the analyte concentration in blood of human body, wrap
Include but be not limited to glucose, sodium ion and potassium ion), as shown in fig. 6, including detection unit, signal transmitting apparatus, data processing
Unit；
Detection unit and signal transmitting apparatus are fixed in a shell, which plays the work of protection internal electronic element
With, and a power supply (not shown in figures) is additionally provided in the shell, for powering for the electronic component in shell.
Detection unit includes implanted analyte sensor 20, the fixing piece 10 for fixing implanted analyte sensor
With sensor current data generating device, the present invention in sensor 20 refer to have double-sided microelectrodes sensor.
In general, as shown in Figure 1, the sensor 20 of double-sided microelectrodes includes front 22 and reverse side 23, in obverse and reverse
Upper end is respectively provided with electrode interface 21 (be located at interface area), is equipped with working electrode 25 in positive 22 lower ends and to electrode 24,
Reference electrode 26 is equipped in 23 lower end of reverse side.Wherein, working electrode 25, human body is implanted to electrode 24 and reference electrode 26 etc.
Interior detecting electrode is summarised as electrode district.Electrode district and interface area are indicated with box in the figure.
As Figure 2-Figure 5, the fixing piece 10 for implanted analyte sensor of the invention includes support portion 2, is held
Receive portion 1, conductive path 3 and through hole 4.Wherein, receiving portion 1 by 14, receiving portion side wall 12 at the top of receiving portion, receiving portion bottom and
Receiving portion inner wall 13 is constituted, and support portion 2 is connected to 1 bottom of receiving portion and forms receiving portion bottom platform 11；Through hole 4 is located at branch
It is open at one end in receiving portion bottom platform 11 on support part 2；Conductive path 3 is located in receiving portion 1；The conductive path 3 includes extremely
Few two ends.
Fixing piece 10 is fixed on the pedestal 30 of shell, there is a hole on pedestal 30, corresponding with through hole 4, for implanted
The electrode district of analyte sensor 20 passes through.Wherein, working electrode 25, to the implantation such as electrode 24 and reference electrode 26 into the human body
Detecting electrode be summarised as electrode district.
The electrode district of implanted analyte sensor 20 is implanted under human skin by through hole 4, implanted analyte
The interface of 20 reverse side of sensor is electrically connected (conductive path and biography by conductive path 3 and sensor current data generating device
Other existing conductive materials can also be increased between sensor current data generating device, be electrically connected), implanted analysis
The positive interface of object sensor 20 is then electrically connected with existing conductive material, conductive material include but is not limited to graphite,
Conductive tape and copper conductor.
Data exchange is carried out between signal transmitting apparatus and sensor current data generating device, the two can pass through data line
Carry out data exchange, can also by wireless signal (the existing wireless data exchange mode of such as bluetooth, WiFi, radiofrequency signal) into
Row data exchange.To realize any data transmission mode in the prior art, signal transmitting apparatus need to be used and be corresponded in the prior art
Element.
Data exchange is carried out between data processing unit and signal transmitting apparatus, the two can carry out data friendship by data line
It changes, wireless signal can also be passed through.
Sensor current data generating device controls implanted analyte sensor by electric signal and detects subcutaneous analyte,
And the data that implanted analyte sensor generates are received, the data received are transmitted at data by signal transmitting apparatus
Reason unit is processed and displayed.Such as the function may be implemented in miniature processing chip on the market.
Data processing unit can be intelligent terminal (smart phone, computer, plate etc.), be also possible to contain display
One component of screen, data processing chip, wherein inside the shell, display screen is installed on the shell for data processing chip installation.
In above-mentioned implanted analyte sensor system, in addition to fixing piece 10, other components and connection type are simultaneously
Without creative technical characteristic.
The present invention provides a kind of fixing pieces for implanted analyte sensor, for the biography with double-sided microelectrodes
Sensor (refers to Fig. 1).
Such as Fig. 2-1~Fig. 2-3, Fig. 3-1~Fig. 3-4, Fig. 4-1~Fig. 4-4, the cross section of through hole 4 can be triangle,
Round or semicircle etc., for passing through for 20 implant part of sensor (including electrode district), implant part is inserted after passing through through hole 4
Enter it is subcutaneous to human body, quantity be 1.Through hole 4 and 1 two side walls of receiving portion are equidistant, such as Fig. 2-1~Fig. 2-2；It can also be biased to
On one side, such as Fig. 2-3.Since sensor 20 is possible to be not enough to pierce through skin, need thus and puncture needle commonly used in the art
Want to combine, so that the detecting electrode of sensor 20 is satisfactorily implanted subcutaneous.
Such as Fig. 3-1~Fig. 3-4, shown in Fig. 4-1~Fig. 4-4 and Fig. 5, conductive path 3 is used for and the reverse side of sensor 20 electricity
The interface 21 of pole is electrically connected with reference to Fig. 1, which at least has there are two end, such as Fig. 4-2b, in addition to first
There are also the second end 32 and third ends 33 outside end 31.3 quantity of conductive path is at least one, or two and with
On, quantity is related to the opposite electrode interface quantity of sensor 20.Such as when reverse side increases by a temperature sense electrode, conduction is logical
The quantity on road need to increase by one.When the quantity of conductive path is greater than one, conductive path 3 can be arranged along same layout type
Cloth can also be arranged using various ways.The material of conductive path 3 can be conductive metal, conducting polymer or its
It has the material (such as graphite) of electric action, is the shape property of can choose threadiness, column, sheet etc..The present invention with
There are two for the conductive path of end, be specifically first end 31 and the second end 32 for tool.Wherein, first end 31 is located at
The side of fixing piece 10, and between the interface between opposite electrode and fixing piece 10, the second end 32 is located at fixing piece 10
Other side, and interface corresponding with sensor current data generating device is connected.
Opposite electrode refers to the electrode towards fixing piece, and example is located at the reference electrode 26 of lower surface as shown in figure 1；If certain work
Make electrode 25 and to electrode 24 towards fixing piece 10, opposite electrode can also refer to the two electrodes 24 and 25.Technology of the invention
For scheme description is all using reference electrode 26 as opposite electrode.In addition, being electricity to electrode 24, working electrode 25 and reference electrode 26
The common technology of chemical analysis field, the technical characteristic without other creativeness.
With reference to Fig. 2-1~2-3, Fig. 3-1, Fig. 3-4, Fig. 4-1, Fig. 4-4, receiving portion 1 is by receiving portion side wall 12, receiving portion top
Portion 14, receiving portion bottom and receiving portion inner wall 13 are constituted, and are formed together receiving portion bottom platform 11 with support portion, for accommodating
The upper end electrode 21 of sensor 20.When being equipped with groove 5 in some embodiments, in receiving portion 1, groove 5 is for engaging and fixing
The upper end of sensor 20.Such as Fig. 3-3 and Fig. 4-3.
Support portion 2 is used to support receiving portion 1, and through hole 4 also passes through support portion 2.
In the present invention, fixing piece 10 can also include interconnecting piece (not shown in the figure), and interconnecting piece is used for fixing piece 10
It is fixed on the pedestal 30 of analyte detection apparatus, fixed mode can be detachable (buckle, be screwed on, plugging) or non-disconnectable
Unload formula (be bonded using adhesive, be integrally formed with pedestal 30).Wherein, the fixed form of buckle is best.In use, can
Sensor 20 is directly inserted into the corresponding position of fixing piece 10 or is pulled out.It can be passed in this way with quick-replaceable
Sensor 20, not only reduces replacing construction, also simplifies replacement step.
Analyte detection apparatus, which refers to, contains the device of detection unit, signal transmitting apparatus and power supply, which passes through viscous
The modes such as knot, binding are fixed on the skin.
In the present invention, fixing piece can also include sealing ring 8, can also be with hydrophobic thin such as the O-shaped rubber ring in Fig. 3-1
Film or other current materials with sealing function replace, and sealing ring quantity is at least 1, is arranged in around support portion 2,
Such as Fig. 3-1~Fig. 3-4, shown in Fig. 4-1~Fig. 4-4.Sealing ring 8 is used for waterproof, specifically, to prevent the fixed position of human body from touching
It (such as has a bath, swim) when touching water, water penetrates into inside monitoring device, to influence internal electronic component.
5 quantity of groove is 1~3, is located at receiving portion side wall 12 or receiving portion bottom platform 11 or the group of both
It closes.The recessed poor 5 setting distribution in part can refer to Fig. 2-1~Fig. 2-3.Groove 5 is used for the interface area 27 of alignment sensor 20 and limits
Interface area 27 processed is mobile, positioned at the groove 5 of side wall also has the function of that interface area 27 is guided to be inserted into.Wherein, such as Fig. 2-1~2-3,
The width x of groove 5 is greater than the edge thickness of interface area 27, and the range of difference is to be less than or equal to 0.5mm, further greater than 0mm
It can be 0.05~0.2mm, preferably 0.1mm, prevent difference is too small from causing insertion difficult, difference is excessive to be caused also for preventing
The effect for limiting interface area reduces；Similarly, the width y for accommodating inner wall is greater than the length of interface area, the range of difference be greater than
0mm is less than or equal to 0.5mm, may further be 0.05~0.2mm, preferably 0.1mm, prevent difference is too small from causing to be inserted into
Difficulty, also for preventing, difference is excessive to cause the effect for limiting interface area to reduce.Above-mentioned receiving inner wall width y, numerical value model
It encloses for 2~5mm.
Such as Fig. 3-1-c, Fig. 3-2c, Fig. 3-3b, Fig. 4-1b, Fig. 4-2c, Fig. 4-3b, Fig. 4-4a, the material that conductive sheet 6 uses
It can be conductive metal, conducting polymer or other materials (such as graphite) with electric action.6 quantity of conductive sheet can be with
1, or multiple.An end or multiple ends for conductive sheet and conductive channel is electrically connected.It is connected when needing to increase
When intensity, conductive adhesives (conducting resinl, conductive tape) can be used conductive sheet 6 and first end 31 and/or second end
Portion 32 is electrically connected: when connecting with first end 31, the interface 21 of first end 31 and opposite electrode can be made to be conductively connected
It obtains more preferably；When connecting with the second end 32, the electric conductivity of the second end 32 Yu sensor current data generating device can also be made
It is more stable outstanding.
In the present invention, conductive channel 3 can run through the receiving portion 1 of fixing piece, and two ports of conductive channel 3 is made to distinguish position
It is located at the inner wall 13 of accommodating chamber, another port in 12/ top 14 of inner wall 13 and side wall of receiving portion 1, that is, a port
Positioned at side wall 12 or top 14.At this point, fixing piece is equipped with conductive vias 7, such as Fig. 2-1~Fig. 2-3, Fig. 3-1~Fig. 3-2, this is led
Electric duct 7 (Fig. 3-1a and Fig. 3-2a) for conductive path 3 for passing through, so that it is solid to be directed toward the first end 31 of conductive path 3
The receiving portion inner wall 13 for determining part 10, such as Fig. 3-1b, and the second end 32 of conductive path 3 is located on other faces of receiving portion 1, such as
The second end 32 in Fig. 3-2b is located at the back side side wall 12 of fixing piece receiving portion 1, but this does not imply that the second end 32 must
The face must be located at, be also possible to side in addition to this, such as Fig. 3-4.
In one embodiment, first end 31 is directed toward receiving portion inner wall 13, and it can be with the reverse side of sensor 20
The interface 21 of electrode is electrically connected, as shown in Fig. 3-1b.
In one embodiment, conductive sheet 6, opposite electrode are equipped between first end 31 and the opposite electrode of sensor 20
Interface 21 and conductive sheet 6 be electrically connected, be electrically connected between first end 31 and conductive sheet 6, conductive sheet 6 is located in receiving portion
13 surface of wall, as shown in Fig. 3-1c.
In one embodiment, the second end 32 is located at the back side side wall 12 of fixing piece 10, can be with sensor electricity
The interface of flow data generating device is electrically connected, as shown in Fig. 3-2b.
In one embodiment, the back side side wall 12 of fixing piece 10 is equipped with conductive sheet 6,6 electricity of the second end 32 and conductive sheet
Property connection, while conductive sheet 6 can be also electrically connected with the interface of sensor current data generating device, and enhance electric signal
Bonding strength, as shown in Fig. 3-2c.
In one embodiment, conductive vias 7 is curve or broken line, and the first end 31 of conductive path 3 is directed toward receiving portion
Inner wall 13, and the second end 32 is directed toward on side wall 12 or the top 14 of fixing piece, such as Fig. 3-4a and Fig. 3-4b.
In a preferred embodiment, conductive sheet 6 is equipped between first end 31 and the opposite electrode 21 of sensor 20,
The back side of fixing piece also is provided with a conductive sheet 6, and the second end 32 and conductive sheet 6 are electrically connected, and sensor 20 is inserted into fixing piece 10
Effect afterwards is as shown in Fig. 3-3a and Fig. 3-3b.
In the present invention, conductive channel 3 can be located at the outer surface of the receiving portion 1 of fixing piece, also, the two of conductive channel 3
A port is located at 12/ top 14 of inner wall 13 and side wall of receiving portion 1, that is, a port is located at the inner wall of accommodating chamber
13, another port is located at side wall 12 or top 14.At this point, receiving portion 1 does not set conductive vias 7, conductive path 3 is along receiving portion 1
Surface distribution, so that the first end 31 of conductive path 3 be made to be located at receiving portion inner wall 13 (such as Fig. 4-1, Fig. 4-4, Fig. 4-3a institute
Show), the second end 32 is located at the side wall 12 of the top 14 (shown in Fig. 4-2a) of fixing piece, side (shown in Fig. 4-4a, Fig. 4-4c)
Or the side wall 12 (shown in Fig. 4-2b, Fig. 4-2c, Fig. 4-3b, Fig. 4-4b) at the back side.In order to increase conductive path 3 in 10 table of fixing piece
The adhesion strength in face can be arranged one layer of adhesion layer between 10 surface of conductive path 3 and fixing piece or be carried out with adhesive
Bonding, in addition to this, can also be fixed with the mode inlayed.
In the present invention, conductive channel 3 a part of can run through receiving portion 1, and another part is located at the receiving portion 1 of fixing piece
Outer surface, also, two ports of conductive channel 3 are located at the inner wall and sidewall/top of receiving portion 1.Such as shown in Fig. 5,
A part of (black dotted lines part) can be extended through fixing piece by conductive path 3, and another part (solid black lines part) is along appearance
Receiving 1 surface of portion extends to the side wall 12 at 1 back side of receiving portion, is also possible to the side wall 12 of top 14 or side, otherwise can also be with.
Claims (12)
1. a kind of fixing piece for implanted analyte sensor, for the sensor with double-sided microelectrodes, feature exists
In the fixing piece includes support portion, receiving portion, conductive path and through hole；Receiving portion is by receiving portion top, receiving portion side
Wall, receiving portion bottom and receiving portion inner wall are constituted, and support portion is connected to receiving portion bottom and forms receiving portion bottom platform；Through hole
It is open at one end in receiving portion bottom platform on support portion；Conductive path is located in receiving portion；The conductive path includes extremely
Few two ends.
2. the fixing piece according to claim 1 for implanted analyte sensor, which is characterized in that described conductive logical
Road includes first end and the second end, and the second end and first end are electrically connected.
3. the fixing piece according to claim 2 for implanted analyte sensor, which is characterized in that conductive path passes through
Wear receiving portion.
4. the fixing piece according to claim 2 for implanted analyte sensor, which is characterized in that conductive path position
In receiving portion outer surface.
5. the fixing piece according to claim 2 for implanted analyte sensor, which is characterized in that conductive path one
Receiving portion is run through in part, and another part is located at receiving portion outer surface.
6. being used for the fixing piece of implanted analyte sensor according to claim 3 or 5, which is characterized in that receiving portion
With the conductive vias for accommodating conductive path.
7. being used for the fixing piece of implanted analyte sensor according to one of claim 3-5, which is characterized in that first
End is located at receiving portion inner wall, and the second end is located at the top of receiving portion or side wall.
8. the fixing piece according to claim 2 for implanted analyte sensor, which is characterized in that conductive path is also
Including the third end being located in receiving portion；Third end and the second end and first end are electrically connected.
9. the fixing piece according to claim 1 for implanted analyte sensor, which is characterized in that described accommodation section
It is equipped with one to three groove；Groove is located at receiving portion inner wall or bottom.
10. the fixing piece according to claim 1 for implanted analyte sensor, which is characterized in that the fixation
Part also wraps the conductive sheet being located in receiving portion；The end of the conductive sheet and conductive path is electrically connected.
11. a kind of implanted analyte sensor system, which is characterized in that at detection unit, signal transmitting apparatus, data
Manage unit；
Detection unit and signal transmitting apparatus are fixed in a shell, and a power supply is additionally provided in the shell, for for
Electronic component power supply in shell；
Detection unit includes described in one of implanted analyte sensor, claim 1-10 for fixing implanted analyte
The fixing piece and sensor current data generating device of sensor.
12. implanted analyte sensor system according to claim 11, which is characterized in that fixing piece is by being connected to
Interconnecting piece on support portion is fixed on outer casing base.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811348478.8A CN109846494B (en) | 2018-11-13 | 2018-11-13 | Anchors and sensor systems for implantable analyte sensors |
| CN202210313887.4A CN114732401A (en) | 2018-11-13 | 2018-11-13 | Detection unit of implantable analyte sensor |
| PCT/CN2019/117011 WO2020098583A1 (en) | 2018-11-13 | 2019-11-11 | Fixed member for implanted analyte sensor and sensor system |
| EP19884806.1A EP3881762B1 (en) | 2018-11-13 | 2019-11-11 | Fixed member for implanted analyte sensor and sensor system |
| US17/293,420 US20220117519A1 (en) | 2018-11-13 | 2019-11-11 | Fixed member for implanted analyte sensor and sensor system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811348478.8A CN109846494B (en) | 2018-11-13 | 2018-11-13 | Anchors and sensor systems for implantable analyte sensors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210313887.4A Division CN114732401A (en) | 2018-11-13 | 2018-11-13 | Detection unit of implantable analyte sensor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109846494A true CN109846494A (en) | 2019-06-07 |
| CN109846494B CN109846494B (en) | 2022-04-19 |
Family
ID=66889997
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210313887.4A Pending CN114732401A (en) | 2018-11-13 | 2018-11-13 | Detection unit of implantable analyte sensor |
| CN201811348478.8A Active CN109846494B (en) | 2018-11-13 | 2018-11-13 | Anchors and sensor systems for implantable analyte sensors |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210313887.4A Pending CN114732401A (en) | 2018-11-13 | 2018-11-13 | Detection unit of implantable analyte sensor |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20220117519A1 (en) |
| EP (1) | EP3881762B1 (en) |
| CN (2) | CN114732401A (en) |
| WO (1) | WO2020098583A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020098583A1 (en) * | 2018-11-13 | 2020-05-22 | 利多(香港)有限公司 | Fixed member for implanted analyte sensor and sensor system |
| CN112057084A (en) * | 2020-09-07 | 2020-12-11 | 浙江大学 | Double-sided screen printing electrode based on flexible plastic substrate and method thereof |
| CN112294312A (en) * | 2019-08-02 | 2021-02-02 | 华广生技股份有限公司 | Physiological signal monitoring device and sensor bracket thereof |
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2018
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2019
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| CN112057084A (en) * | 2020-09-07 | 2020-12-11 | 浙江大学 | Double-sided screen printing electrode based on flexible plastic substrate and method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3881762A1 (en) | 2021-09-22 |
| CN109846494B (en) | 2022-04-19 |
| EP3881762A4 (en) | 2022-08-31 |
| EP3881762B1 (en) | 2023-12-20 |
| CN114732401A (en) | 2022-07-12 |
| WO2020098583A1 (en) | 2020-05-22 |
| US20220117519A1 (en) | 2022-04-21 |
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