CN109833450A - A kind of Chinese medicine and preparation method thereof for treating frequency symptoms - Google Patents
A kind of Chinese medicine and preparation method thereof for treating frequency symptoms Download PDFInfo
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- CN109833450A CN109833450A CN201711208658.1A CN201711208658A CN109833450A CN 109833450 A CN109833450 A CN 109833450A CN 201711208658 A CN201711208658 A CN 201711208658A CN 109833450 A CN109833450 A CN 109833450A
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Abstract
The present invention relates to a kind of for treating the Chinese medicine of frequency symptoms, which is mainly made of intelligence development, dog bone, bacterium osmanthus, filliform cassytha herb, chicken yellow skin, the sub- Six-element medicine of ginkgo.The present invention further refers to the preparation method of the medicine, first adds water to cook the above medicinal material or volatile oil first is extracted in intelligence development, bacterium osmanthus before decoction, and extracting solution is then condensed into thick paste and auxiliary material or volatile oil granulation is added.Pre-clinical animal studies show warm kidney reducing urination of the present invention, and it is excessive to cure mainly children's functionality enuresis nocturna.The number of micturitions of the normal mouse and deficiency of yang mouse of giving Water l oad can significantly be reduced；Significantly reduce the urine volume that first subtracts type deficiency of yang rat；There is significantly relexation to rabbit in vitro bladder detrusor, the contraction to rabbit in vitro bladder detrusor caused by anti-acetylcholine.
Description
Technical field
The invention belongs to a kind of Chinese medicines, specifically a kind of for treating the Chinese medicine of frequency symptoms, the present invention is further mentioned
For preparation method.
Background technique
It is high, short treating period for treating the drug of frequency symptoms to lack a kind of curative effect for the country at present, generallys use traditional Chinese and western medicine
In conjunction with being treated, but treatment is not thorough, easy to recur, has side effect.
Summary of the invention
Mesh of the invention it is to provide a kind of curative for effect, few side effects, has and specifically treat infantile enuresis effect
Chinese patent drug, it is above-mentioned to overcome the shortcomings of.
To achieve the above object, the invention has the characteristics that it is the medicament made of the raw material of following weight proportions:
1-5 parts of bacterium osmanthus of 4-15 parts of dog bone of 10-25 parts of intelligence development
30-45 parts of chicken yellow skin of 10-30 parts of filliform cassytha herb
The preferable raw material weight proportions for constituting above-mentioned medicament are:
2-4 parts of bacterium osmanthus of 6-12 parts of dog bone of 15-20 parts of intelligence development
25-35 parts of chicken yellow skin of 16-24 parts of filliform cassytha herb
The optimum feed stock weight ratio proportion for constituting above-mentioned medicament is:
16 parts of 10 parts of dog bone, 3 parts of bacterium osmanthus of intelligence development
20 parts of filliform cassytha herb, 30 parts of chicken yellow skin
The above-mentioned Chinese medicine for being used to treat frequency symptoms, can also be added the corrigent of drug excipient or drug.Drug excipient
It can be one of sucrose, starch, magnesium stearate, sorbierite, microcrystalline cellulose, superfine silica gel powder, sodium carboxymethyl starch or one
Kind or more combination, by medicine preparation of the invention at convenient for the particle taken or tablet or capsule.Drug corrigent can be with
It is one of stevioside, oligomeric maltose, lactose, edible essence or more than one combination, so that prepared medicament
With good sweet felling, after overcoming several taste Chinese herbal medicine compatibilities, the five tastes mix, bitter peppery acid salty the drawbacks of having a nasty taste.Drug
Coating can be one of film-coating, semi-film coating, enteric coating etc., to reach moisture-proof, reduction bad smell, mitigate and pierce to stomach
Swash or destroyed and achieved the effect that by gastric juice beauty, easily take.
Specifically, when preparing drug of the invention, comprising the following steps:
(1) weigh raw material by component proportion, add water to cook together or first by intelligence development, bacterium osmanthus extract volatile oil again with other raw materials
It adds water to cook together, collecting decoction is condensed into medicinal extract.
(2) auxiliary material is added into medicinal extract corresponding pharmaceutical dosage form is made or auxiliary material and intelligence development, bacterium osmanthus are added into medicinal extract
Corresponding dosage form is made to get Chinese medicine of the invention in volatile oil.
The step of one of optimal preparation method are as follows:
(1) intelligence development, bacterium osmanthus Jia Shui 5-10 hours extraction volatile oil of distillation are weighed by component proportion, collects volatile oil and is simultaneously pasted with β-ring
Spermatophore closes, and obtains the inclusion compound of intelligence development, bacterium osmanthus volatile oil.
(2) weigh that dog bone, filliform cassytha herb, chicken yellow skin are added to intelligence development, bacterium osmanthus mentions in the dregs of a decoction after oil by component proportion, together
It decocts twice, collecting decoction is condensed into medicinal extract.
(3) by step (2) medicinal extract and starch and volatile oil clathrate compound mixing granulation to get drug of the invention
Grain.
Characteristic of the invention is warming and invigorating kidney Yang, takes into account promoting the dispersing function of the lung fortune spleen, three dirty weaknesses is improved, tightly the generation enuresis
The lung spleen kidney three of disease dirty deficient and the insufficient emphasis as treatment, clinical long-term practice, fructus alpiniae oxyphyllae, bacterium osmanthus, filliform cassytha herb temperature compensation
Kidney spleen, with warm lower member；The warm lung of dog bone rises clearly, and lung qi must declare, and astringes the lung to stop cough and is reduced just with the sub- warming lung, benefiting vital energy of ginkgo, two medicines are simultaneously
A conjunction is opened with one, the function of lung qi tonneau water channel is made more to bring out the best in each other；Chicken yellow skin help digestion transport spleen only drown, its warm kidney of Six-element Chinese medicine a surname
The rules for the treatment of of lung fortune spleen obtain good effect repeatly in clinic, and drug effect can be such that first tremble with fear under infant goes, and the lung qi of the part of the body cavity above the diaphragm housing the heart and lungs is sensible, middle coke
Spleen is transported strong, and qiactivity of triple energizer is sensible along adjusting, and the gasification of aqueous restores normal, then the disease of the enuresis can speed be cured.
Dog bone has been the common medicine of this disease of clinical treatment at present, and it is theoretical in ancient times for being applied to medicine treatment enruesis
On the basis of the new harvest constantly explored with modern age clinician, new experience.ZHANG Jie bin refers in " a Jing Yue's complete work incontinence of urine piece "
Out " all persons that controls urinary incontinence, ancient prescription are mostly used astringent method, this is solid preferably so, agent of right astringent method, but its solid portal, this meaning also treated the symptoms,
Rather than the road Sai Yuanzhi, though Gai little Shui is conducive to kidney, and connect lung on kidney, kidney water cannot be taken the photograph eventually if lung qi is had no right, therefore the person of harnessing the river must
Gas must be controlled, controlling kidney, person must control lung ".This opinion and directive function very enlightening to the treatment of this disease of Zhang Shi.Dog bone pungent-warm slight bitter, people
Lung and bladder meridian lead to water source up and down, and all medicine perforations three that can unite are burnt, and warm-natured energy activating YANG and prormoting functioning of QI promoting the dispersing function of the lung, regulating fluid apssage makes bladder
Gasification is restored, and folding degree of the having enuresis must stop.
Bacterium osmanthus, Gan Xinre return kidney spleen conscience to pass through, the fire of energy pyretic tonification of kidney yang." collected statements on the herbal foundation " thinks that the medicine is to control the inferior first void
It is cold, the insufficiency of the kidney yang, the key medicine of lung cold cough and asthma.Osmanthus liver ball in " return of spring of ten thousand medicines " is i.e. using bacterium osmanthus and chicken gizzard as ball, also specially to control
The efficacious prescriptions of infantile enuresis.Above two medicine is ministerial drug.
Filliform cassytha herb, Xin Ganping, people's liver kidney two warp have the effect of tonifying kidney and benefiting sperm reducing urination, cure mainly frequent urination, it is dripping not to the utmost,
The diseases such as incontinence of urine.The wuzi yanzong pills in Fu rabbit ball and " prescriptions worth thousand gold " in " disease controls criterion " point out the medicine beneficial to kidney, contracting
Urine controls the effect of the enuresis.
Chicken yellow skin, sweet put down remove food retention into the spleen channel, transport taste, control the function of incontinence of urine.There is chicken in Shennong's Herbal, " Bie Lu "
Calusena lansium, chicken ribs have the effect of " main incontinence of urine ", " main diuresis, except heat is only tired ".There are chicken intestines to dissipate in " Qianjin Yao Fang " of SUN Si miao,
" the new collection side of children children " has the record of the special for treating children enuresis such as chicken yellow skin, mantis egg-case." pediatrics releases mystery " points out " to sleep middle urine from out
Person, name are wet the bed, and dissipate master's with chicken ribs intestines." this medicine be adjutant.
Pre-clinical animal studies warm kidney reducing urination according to the present invention, cures mainly frequency symptoms, has selected to normal mouse and the deficiency of yang
The influence of mouse Water l oad number of micturitions；The influence of type deficiency of yang rat Water l oad urine volume is subtracted to first and in vitro bladder smooth muscle is received
The influence of contracting has carried out experimental study.The result shows that: drug of the present invention can significantly reduce give Water l oad normal mouse and
The number of micturitions of deficiency of yang mouse；Significantly reduce the urine volume that first subtracts type deficiency of yang rat；Have significantly to rabbit in vitro bladder detrusor
Relexation, the contraction to rabbit in vitro bladder detrusor caused by anti-acetylcholine.The concrete outcome of test is as follows:
1. the present invention can be reduced number of micturitions.To normal mouse large dosage 39.2g/kg containing crude drug (20 times of suitable quantity),
Middle dosage 19.6g/kg containing crude drug (10 times of suitable quantity), low dose 9.8g/kg containing crude drug (5 times of suitable quantity),
Continuous gavage 11 days with blank control group than can make Water l oad mouse number of micturitions reduce within the regular hour.The present invention
It can be reduced the number of micturitions of deficiency of yang type mouse.Hydrocortisone causes deficiency of yang mouse number of micturitions to increase, and model is set up, with blank group
Comparing difference is significant.Suoquan Wan and kidney Bao oral liquid two positive groups are same to deficiency of yang type mouse in 1 hour to 4 hours after Water l oad
Sample has the function of reducing number of micturitions.The large, medium and small each dosage group number of micturitions of drug of the present invention is considerably less than model group.
2. the urine volume that the present invention can be reduced rat.The present invention causes first to subtract type deficiency of yang rat to bilateral thyroid gland is extractd
Urine volume is also reduced effect, 1-2 hours drug bolus 19.6g/kg containing crude drug (suitable quantities 10 of the present invention after Water l oad
Again) and two positive groups reduce within the regular hour urine volume of deficiency of yang rat；Low dose (the phase of 9.8g/kg containing crude drug
When 5 times of quantity) in Water l oad after reduction in 2 hours urinate (P < 0.01=；It is consistent with blank group after 3 hours, no conspicuousness
Difference.
3. the present invention has relexation to rabbit in vitro bladder detrusor.Large dosage 12mg/ml containing crude drug；Middle dosage is containing life
Medicine 6mg/ml；Low dose 3mg/ml containing crude drug makes the relaxation of rabbit in vitro bladder detrusor, and tension reduces, and each dosage repeats
More than 10 times, as a result unanimously.Energy antagonism acetylcholine of the present invention shrinks the effect of rabbit in vitro bladder detrusor, dosage increasing action
Enhancing, effect are obvious.
Specific embodiment
The present invention is described in detail with reference to embodiments, but should not be construed as limiting the invention.
Embodiment 1:
It takes intelligence development 6kg, dog bone 4kg, bacterium osmanthus 1kg, filliform cassytha herb 10kg, chicken yellow skin 20kg to add water to cook together 2 times, filters, merge
Filtrate is simultaneously condensed into thick paste, and by thick paste and appropriate amount of starch mixing granulation, appropriate magnesium stearate is added as profit in the particle made
Lubrication prescription, tabletting is up to tablet of the present invention.
The tablet of the present invention has the function of warm kidney promoting the dispersing function of the lung, transporting taste, reducing urination for preventing enuresis, can be used for treating 5 years old or more youngster
Child not can control after falling asleep to urinate and bed-wetting person.Or see usually refreshing tired, easy cough, receive less, tongue nature is light, whitish tongue, deep,thready and forceless pulse
Functional nocturnal enuresis.
Embodiment 2:
It takes intelligence development 12kg, bacterium osmanthus 3kg that water is added to distill 6 hours, collect volatile oil and beta-cyclodextrin inclusion compound is added, obtain inclusion compound；Medicine
Slag and dog bone 10kg, filliform cassytha herb 20kg, chicken yellow skin 30kg is admixed together adds water to cook 2 times, filters, merging filtrate is simultaneously condensed into
The thick paste that relative density is 1.35.The inclusion compound of starch and volatile oil is added into thick paste, mixing granulation is about made 20kg
Grain dispenses (every bag of 5g) to get drug granule of the invention.
Major function of the invention is the same as 1 warm water delivery service of embodiment.
Embodiment 3:
In the present embodiment, the preparation method, major function of the medicine and usage and dosage are with embodiment 2, except that prescription
The dosage different from of Chinese medicine, medicinal material dosage is respectively: intelligence development 20kg, dog bone 10kg, bacterium osmanthus 2kg, filliform cassytha herb 10kg, chicken
Calusena lansium 40kg.
Claims (6)
1. a kind of for treating the Chinese medicine of frequency symptoms, it is characterised in that it is made of the raw material of following weight proportions
Medicament:
1-5 parts of bacterium osmanthus of 4-15 parts of dog bone of 10-25 parts of intelligence development
30-45 parts of chicken yellow skin of 10-30 parts of filliform cassytha herb.
2. it is as described in claim 1 for treating the Chinese medicine of frequency symptoms, wherein the weight ratio proportion of each raw material is:
2-4 parts of bacterium osmanthus of 6-12 parts of dog bone of 15-20 parts of intelligence development
25-35 parts of chicken yellow skin of 16-24 parts of filliform cassytha herb.
3. it is as described in claim 1 for treating the Chinese medicine of frequency symptoms, wherein the weight ratio proportion of each raw material is:
16 parts of 10 parts of dog bone, 3 parts of bacterium osmanthus of intelligence development
20 parts of filliform cassytha herb, 25 parts of chicken yellow skin.
4. Chinese medicine as claimed in any one of claims 1-3, pharmaceutical composition can be with according to conventional process of Chinese material medica preparation
Any pharmaceutical dosage form for being suitable for clinical use is made.
5. Chinese medicine as claimed in any one of claims 1-3, it is characterised in that drug excipient or drug corrigent is added.
6. the step of Chinese medicine as claimed in any one of claims 1-3, preparation method are as follows:
(1) weigh raw material by component proportion, add water to cook together or first by intelligence development, bacterium osmanthus extract volatile oil again with other raw materials
It adds water to cook together, collecting decoction is condensed into medicinal extract；
(2) auxiliary material is added into medicinal extract corresponding pharmaceutical dosage form is made or auxiliary material and intelligence development, the volatilization of bacterium osmanthus are added into medicinal extract
Corresponding dosage form is made in oil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711208658.1A CN109833450A (en) | 2017-11-27 | 2017-11-27 | A kind of Chinese medicine and preparation method thereof for treating frequency symptoms |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711208658.1A CN109833450A (en) | 2017-11-27 | 2017-11-27 | A kind of Chinese medicine and preparation method thereof for treating frequency symptoms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109833450A true CN109833450A (en) | 2019-06-04 |
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ID=66879168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711208658.1A Pending CN109833450A (en) | 2017-11-27 | 2017-11-27 | A kind of Chinese medicine and preparation method thereof for treating frequency symptoms |
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| Country | Link |
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| CN (1) | CN109833450A (en) |
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2017
- 2017-11-27 CN CN201711208658.1A patent/CN109833450A/en active Pending
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Application publication date: 20190604 |