CN109831915A - 具有强力抗肿瘤活性的靶向tlr9的球形核酸 - Google Patents

具有强力抗肿瘤活性的靶向tlr9的球形核酸 Download PDF

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Publication number
CN109831915A
CN109831915A CN201780038253.XA CN201780038253A CN109831915A CN 109831915 A CN109831915 A CN 109831915A CN 201780038253 A CN201780038253 A CN 201780038253A CN 109831915 A CN109831915 A CN 109831915A
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sna
cancer
core
oligonucleotide
cell
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Pending
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CN201780038253.XA
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English (en)
Chinese (zh)
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S·纳拉加特拉
B·安德森
E·坎迪马拉
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Exicure Inc
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Aurasense Therapeutics Inc
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Priority to CN202310498290.6A priority Critical patent/CN116875609A/zh
Publication of CN109831915A publication Critical patent/CN109831915A/zh
Pending legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
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    • A61K9/10—Dispersions; Emulsions
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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CN201780038253.XA 2016-05-06 2017-05-05 具有强力抗肿瘤活性的靶向tlr9的球形核酸 Pending CN109831915A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310498290.6A CN116875609A (zh) 2016-05-06 2017-05-05 具有强力抗肿瘤活性的靶向tlr9的球形核酸

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662333139P 2016-05-06 2016-05-06
US62/333,139 2016-05-06
US201762480936P 2017-04-03 2017-04-03
US62/480,936 2017-04-03
PCT/US2017/031423 WO2017193084A1 (en) 2016-05-06 2017-05-05 Tlr9-targeted spherical nucleic acids having potent antitumor activity

Related Child Applications (1)

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CN202310498290.6A Division CN116875609A (zh) 2016-05-06 2017-05-05 具有强力抗肿瘤活性的靶向tlr9的球形核酸

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CN109831915A true CN109831915A (zh) 2019-05-31

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CN201780038253.XA Pending CN109831915A (zh) 2016-05-06 2017-05-05 具有强力抗肿瘤活性的靶向tlr9的球形核酸
CN202310498290.6A Pending CN116875609A (zh) 2016-05-06 2017-05-05 具有强力抗肿瘤活性的靶向tlr9的球形核酸

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US (1) US20250304974A1 (https=)
EP (1) EP3452600A4 (https=)
JP (1) JP7062599B2 (https=)
KR (1) KR20190005184A (https=)
CN (2) CN109831915A (https=)
AU (2) AU2017261357B2 (https=)
CA (1) CA3023449A1 (https=)
WO (1) WO2017193084A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114514015A (zh) * 2019-09-19 2022-05-17 丹麦科技大学 免疫刺激胶束组合物
CN117233391A (zh) * 2023-08-28 2023-12-15 南方医科大学南方医院 一种用于预测胃癌免疫治疗和/或化疗疗效的生物标志物及其应用

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TR201908550T4 (tr) 2014-06-04 2019-07-22 Exicure Inc Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi.
US11696954B2 (en) 2017-04-28 2023-07-11 Exicure Operating Company Synthesis of spherical nucleic acids using lipophilic moieties
US20210189397A1 (en) * 2018-05-10 2021-06-24 Northwestern University Self-manageable abnormal scar treatment with spherical nucleic acid (sna) technology
WO2020168005A1 (en) * 2019-02-12 2020-08-20 Exicure, Inc. Combined spherical nucleic acid and checkpoint inhibitor for antitumor therapy
US20220249684A1 (en) * 2019-07-11 2022-08-11 Good T Cells, Inc. Composition for preventing, ameliorating or treating immune checkpoint inhibitor-resistant cancer
US20230102924A1 (en) * 2020-03-10 2023-03-30 Emory University Methods of Treating Cancer Using Checkpoint Inhibitors in Combination with Purine Cleaving Enzymes
TW202206083A (zh) * 2020-04-22 2022-02-16 美商胡桃夾子治療公司 mRNA治療奈米粒子
WO2022050369A1 (ja) 2020-09-04 2022-03-10 国立大学法人大阪大学 抗菌薬を含有するリポソーム製剤
JP7825997B2 (ja) * 2020-12-28 2026-03-09 財團法人工業技術研究院 免疫刺激性リポプレックス、免疫刺激性リポプレックスを含む医薬組成物、およびその用途
US20220370490A1 (en) * 2021-05-21 2022-11-24 Northwestern University Synergistic immunostimulation through the dual activation of tlr3/9 with spherical nucleic acids

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CN101268101A (zh) * 2005-07-07 2008-09-17 科利制药集团公司 用于癌症治疗的抗-CTLA-4抗体和含有CpG基序的合成寡脱氧核苷酸联合治疗
WO2015013673A1 (en) * 2013-07-25 2015-01-29 Aurasense Therapeutics, Llc Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
WO2015187966A1 (en) * 2014-06-04 2015-12-10 Aurasense Therapeutics, Llc Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
WO2016057898A1 (en) * 2014-10-10 2016-04-14 Idera Pharmaceuticals, Inc. Treatment of cancer using tlr9 agonist with checkpoint inhibitors

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CN101268101A (zh) * 2005-07-07 2008-09-17 科利制药集团公司 用于癌症治疗的抗-CTLA-4抗体和含有CpG基序的合成寡脱氧核苷酸联合治疗
WO2015013673A1 (en) * 2013-07-25 2015-01-29 Aurasense Therapeutics, Llc Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
WO2015187966A1 (en) * 2014-06-04 2015-12-10 Aurasense Therapeutics, Llc Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
WO2016057898A1 (en) * 2014-10-10 2016-04-14 Idera Pharmaceuticals, Inc. Treatment of cancer using tlr9 agonist with checkpoint inhibitors

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ARTHUR M. KRIEG 等: "Induction of Systemic TH1-Like Innate Immunity in Normal Volunteers Following Subcutaneous but Not Intravenous Administration of CPG 7909, a Synthetic B-Class CpG Oligodeoxynucleotide TLR9 Agonist", 《J IMMUNOTHER》 *
SARA M MANGSBO等: "Enhanced tumor eradication by combining CTLA-4 or PD-1 blockade with CpG therapy", 《J IMMUNOTHER》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114514015A (zh) * 2019-09-19 2022-05-17 丹麦科技大学 免疫刺激胶束组合物
CN117233391A (zh) * 2023-08-28 2023-12-15 南方医科大学南方医院 一种用于预测胃癌免疫治疗和/或化疗疗效的生物标志物及其应用

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AU2024227671A1 (en) 2024-12-12
CA3023449A1 (en) 2017-11-09
AU2017261357B2 (en) 2024-08-01
EP3452600A1 (en) 2019-03-13
CN116875609A (zh) 2023-10-13
JP7062599B2 (ja) 2022-05-06
KR20190005184A (ko) 2019-01-15
JP2019514985A (ja) 2019-06-06
WO2017193084A1 (en) 2017-11-09
AU2017261357A1 (en) 2018-11-29
EP3452600A4 (en) 2020-01-15
US20250304974A1 (en) 2025-10-02

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