CN109824647B - 4-羟基二苯甲酮腙-2-乙酰基噻吩席夫碱的制备和用途 - Google Patents
4-羟基二苯甲酮腙-2-乙酰基噻吩席夫碱的制备和用途 Download PDFInfo
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- CN109824647B CN109824647B CN201910274635.3A CN201910274635A CN109824647B CN 109824647 B CN109824647 B CN 109824647B CN 201910274635 A CN201910274635 A CN 201910274635A CN 109824647 B CN109824647 B CN 109824647B
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- hydroxybenzophenone
- hydrazone
- acetylthiophene
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- 239000002262 Schiff base Substances 0.000 title description 11
- -1 4-hydroxybenzophenone hydrazone-2-acetylthiophene Schiff base Chemical class 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 17
- 239000013078 crystal Substances 0.000 claims abstract description 17
- 239000000126 substance Substances 0.000 claims abstract description 9
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 claims abstract description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 8
- 238000002844 melting Methods 0.000 claims abstract description 3
- 230000008018 melting Effects 0.000 claims abstract description 3
- WYJOVVXUZNRJQY-UHFFFAOYSA-N 2-Acetylthiophene Chemical compound CC(=O)C1=CC=CS1 WYJOVVXUZNRJQY-UHFFFAOYSA-N 0.000 claims description 14
- 238000006243 chemical reaction Methods 0.000 claims description 13
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 239000003960 organic solvent Substances 0.000 claims description 11
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 239000000047 product Substances 0.000 claims description 8
- MBBAQOHSSWERBC-UHFFFAOYSA-N 4-(C-phenylcarbonohydrazonoyl)phenol Chemical compound OC1=CC=C(C=C1)C(C1=CC=CC=C1)=NN MBBAQOHSSWERBC-UHFFFAOYSA-N 0.000 claims description 7
- 238000003746 solid phase reaction Methods 0.000 claims description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 6
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- 239000002994 raw material Substances 0.000 claims description 5
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- 206010006187 Breast cancer Diseases 0.000 claims description 2
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- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract description 7
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
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- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN110590763B (zh) * | 2019-09-30 | 2022-09-30 | 齐鲁工业大学 | 2-噻唑甲醛-噻吩席夫碱的结构、制备和用途 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104945302A (zh) * | 2015-06-12 | 2015-09-30 | 齐鲁工业大学 | 苯偶酰二腙-3-吲哚甲醛双西弗碱的结构、制备和用途 |
CN105541660A (zh) * | 2016-01-15 | 2016-05-04 | 华南理工大学 | 一种芳基水杨醛-二苯基-吖嗪联肼类化合物及制备与应用 |
CN106749167A (zh) * | 2017-03-29 | 2017-05-31 | 齐鲁工业大学 | 二(噻吩‑2‑亚甲基)丙烷‑1,3‑二胺的制备和用途 |
CN106866618A (zh) * | 2017-03-29 | 2017-06-20 | 齐鲁工业大学 | 二(噻吩‑2‑亚甲基)丁烷‑1,4‑二胺的制备和用途 |
CN107118147A (zh) * | 2017-06-20 | 2017-09-01 | 齐鲁工业大学 | 联苯乙酮腙‑3‑乙酰基吲哚西弗碱的制备、结构和用途 |
CN107266348A (zh) * | 2017-06-20 | 2017-10-20 | 齐鲁工业大学 | 联苯乙酮腙‑3‑吲哚甲醛西弗碱的制备、结构和用途 |
CN107266349A (zh) * | 2017-06-20 | 2017-10-20 | 齐鲁工业大学 | 联苯乙酮腙‑2‑吲哚甲醛西弗碱的制备、结构和用途 |
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Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104945302A (zh) * | 2015-06-12 | 2015-09-30 | 齐鲁工业大学 | 苯偶酰二腙-3-吲哚甲醛双西弗碱的结构、制备和用途 |
CN105541660A (zh) * | 2016-01-15 | 2016-05-04 | 华南理工大学 | 一种芳基水杨醛-二苯基-吖嗪联肼类化合物及制备与应用 |
CN106749167A (zh) * | 2017-03-29 | 2017-05-31 | 齐鲁工业大学 | 二(噻吩‑2‑亚甲基)丙烷‑1,3‑二胺的制备和用途 |
CN106866618A (zh) * | 2017-03-29 | 2017-06-20 | 齐鲁工业大学 | 二(噻吩‑2‑亚甲基)丁烷‑1,4‑二胺的制备和用途 |
CN107118147A (zh) * | 2017-06-20 | 2017-09-01 | 齐鲁工业大学 | 联苯乙酮腙‑3‑乙酰基吲哚西弗碱的制备、结构和用途 |
CN107266348A (zh) * | 2017-06-20 | 2017-10-20 | 齐鲁工业大学 | 联苯乙酮腙‑3‑吲哚甲醛西弗碱的制备、结构和用途 |
CN107266349A (zh) * | 2017-06-20 | 2017-10-20 | 齐鲁工业大学 | 联苯乙酮腙‑2‑吲哚甲醛西弗碱的制备、结构和用途 |
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Denomination of invention: Preparation and application of 4-hydroxybenzophenone hydrazone 2-acetylthiophene Schiff base Effective date of registration: 20231122 Granted publication date: 20210406 Pledgee: Qilu bank Limited by Share Ltd. Ji'nan Changqing branch Pledgor: Shandong Jiqing Technology Service Co.,Ltd. Registration number: Y2023980067041 |
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