CN109781827A - The cation of Propofol migrates spectrum detection method in a kind of expiratory air - Google Patents
The cation of Propofol migrates spectrum detection method in a kind of expiratory air Download PDFInfo
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- CN109781827A CN109781827A CN201711115009.7A CN201711115009A CN109781827A CN 109781827 A CN109781827 A CN 109781827A CN 201711115009 A CN201711115009 A CN 201711115009A CN 109781827 A CN109781827 A CN 109781827A
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Abstract
The invention discloses a kind of cations of Propofol in expiratory air to migrate spectrum detection method.Spectral technology is migrated based on time resolution dynamic dilution sampling device and reagent molecule auxiliary photo-ionisation cation, realize the time resolution dynamic dilution sample introduction of propofol molecule and hydrone in expiratory air, eliminate the influence of sevoflurane in humidity and combined anesthesia in expiratory air, it is quantitative to it by the signal strength of time resolution dynamic dilution sample introduction 2s Propofol, realize the clinical continuous on-line monitoring of Propofol in expiratory air.
Description
Technical field
The present invention is based on time resolution dynamic dilution sampling devices and reagent molecule to assist photo-ionisation cation migration spectrum skill
Art devises a kind of ionic migration spectrum detection method of time resolution dynamic dilution sample introduction, realize in expiratory air Propofol and
The time resolution dynamic dilution sample detection of humidity in expiratory air eliminates humidity and suction-type anesthetic sevoflurane in expiratory air
Influence, it is quantitative to it using the signal strength of sample introduction 2s Propofol, realize the continuous online prison of Propofol in expiratory air
It surveys.
Background technique
Propofol is a kind of common Intravenous Anesthesia agent, and existing more than 50 a countries are used at present.It, can in surgical procedure
The Anesthesia Monitoring leaned on is the important leverage of patient vitals' safety, and existing research shows to monitor on-line the third pool in patient's expiratory air
Phenol concentration is expected to become a kind of noninvasive, online Anesthesia Monitoring means.
Sevoflurane is common suction-type anesthetic in a kind of combined anesthesia, and the sevoflurane of trace, which remains in pipeline, to be influenced
The on-line monitoring of Propofol in expiratory air, suction-type anesthetic sevoflurane severe jamming third is moored in combined anesthesia under negative ion mode
The clinical on-line monitoring of phenol.
Ion mobility spectrometry (Ion Mobility Spectrometry, IMS) is a kind of atmosphere risen the 1970s
Gaseous ion isolation technics under the conditions of pressure provides a kind of simple, quick, highly sensitive analysis means for expiratory air.However,
For ion mobility spectrometry, humidity interference is a serious problem, it can both reduce the sensitivity and selectivity of measurement, and
And it also will increase the complexity of spectrogram, and then substantially reduce the accuracy of result.Therefore, for the expiratory air sample of high humidity, often
The input mode of rule is worthless for ion mobility spectrometry.In current application study, usually by more bundles of capillaries
Column (MCC) or film sampling device are combined with ion mobility spectrometry, utilize the pre-separation ability of MCC or the hydrophobicity of film sampling device
To achieve the purpose that eliminate humidity interference.But due to the combination of MCC and film sampling device, so that the response time of IMS is up to
Minute grade, cannot achieve the real time on-line monitoring of expiratory air.
The present invention provides a kind of detection methods of Propofol in clinical continuous on-line monitoring expiratory air, utilize reagent molecule
It assists photo-ionisation cation to migrate spectral technology, eliminates the interference for remaining sevoflurane in combined anesthesia, binding time differentiates dynamic
Sampling device is diluted, different with adsorptivity of the humidity in tetrafluoro sampling ring using the Propofol in expiratory air, hydrone is first dilute
It releasing and, dilution comes out after Propofol, eliminates the influence of humidity in expiratory air, and the method does not need any sample pre-treatments,
Realize the continuous on-line monitoring of clinic of Propofol in expiratory air.
Summary of the invention
The present invention migrates spectral technology by using reagent molecule auxiliary photo-ionisation cation, and binding time differentiates dynamic dilution
Sampling device eliminates the interference of humidity in sevoflurane and expiratory air in combined anesthesia, realizes facing for Propofol in expiratory air
The continuous on-line monitoring of bed.
Sampling process, sample gas is stored in sampling ring under the action of sampling pump, and carrier gas is directly entered ion and moves at this time
Move pipe, sampling time 10-20s.
Sample introduction process, sampling pump stop while switch three solenoid valves, sample carrier gas at this time flow through sampling ring and by its
In sample molecule be sent into transference tube in detected, in the process, in sampling ring each compound concentration by dynamic
Dilution, sample molecule successively enters ionic reaction area, react with the reagent ion in transference tube reaction zone, generation product from
Son is successively separated by migration area, is reached Faraday plate and is detected, sample injection time 10-15s.
Expiratory air 1 is connected through flow sensor 2 with the interface A of the first two-position three way magnetic valve 3 by pipeline, and the one or two
The interface B of three-way magnetic valve 3 is connect with the Single port of sampling ring 4, the another port of sampling ring 4 and the second two-position three way magnetic valve
5 interface A connection, the interface B of the second two-position three way magnetic valve 5 are connect with 6 air inlet of sampling pump；Sample carrier gas inlet 8 passes through
Pipeline is connect with the interface A of third two-position three way magnetic valve 7, the interface B of third two-position three way magnetic valve 7 by pipeline with just from
Sub- mobility spectrometer carrier gas inlet connection；The interface C of the interface C of third two-position three way magnetic valve 7 and the second two-position three way magnetic valve 5
Connection；The interface C of first two-position three way magnetic valve 3 is connect by pipeline with the air inlet of cation mobility spectrometer sample carrier gas；
Reagent molecule carrier gas inlet 10 is by pipeline through reagent molecule generating device 9 and cation mobility spectrometer organic reagent
The air inlet of molecule carrier gas stream connects；
When sampling, expiratory air 1 is connect under the action of sampling pump 6 by flow sensor 2, the first two-position three way magnetic valve 3
Mouth A, 3 interface B of the first two-position three way magnetic valve, sampling ring 4,5 interface A of the second two-position three way magnetic valve, the second two-position three way electricity
5 interface B of magnet valve, sampling pump 6；
Sample carrier gas is through sample carrier gas inlet 8 by pipeline through 7 interface A of third two-position three way magnetic valve, the three or two three
7 interface B of three-way electromagnetic valve and the entrance of cation mobility spectrometer sample carrier gas are directly entered transference tube；
Organic agent molecule carrier gas through reagent molecule carrier gas inlet 10 by pipeline through reagent molecule generating device 9 with just from
The air inlet of sub- mobility spectrometer organic agent molecule carrier gas stream enters transference tube, sampling time 10-20s；
When sample introduction, switch three solenoid valves while sampling pump 6 stops, third two-position three-way electromagnetic is passed through in sample carrier gas 8
7 interface A of valve, 7 interface C of third two-position three way magnetic valve, 5 interface C of the second two-position three way magnetic valve, the second two-position three way magnetic valve
5 interface A, sampling ring 4,3 interface B of the first two-position three way magnetic valve, 3 interface C of the first two-position three way magnetic valve and cation migrate
The entrance of spectrometer sample carrier gas is directly entered cation migration spectrum；
Organic agent molecule carrier gas through reagent molecule carrier gas inlet 10 by pipeline through reagent molecule generating device 9 with just from
The air inlet of sub- mobility spectrometer organic agent molecule carrier gas stream enters transference tube；The four fluorine tube that sampling ring is 150cm is (outer
Diameter 4mm, internal diameter 3mm), there is the hollow volume of 10.6ml, temperature is constant in 25-30 DEG C of range.
Ion mobility spectrometry is the cation migration spectrum that reagent molecule assists photo-ionisation, and the light ionization source 1 used is non-radioactive
Property vacuum UV lamp, the lamp be commercialization low pressure Kr gas discharge lamp (Kr10.6-B12X50PID lamp, Steven
Sepvest Corporation), the main photon for generating 10.0eV and 10.6eV, light intensity is about 5 × 1011Photons/s,
The photon intensity that the photon intensity of middle 10.0eV accounts for 80%, 10.6eV accounts for 20%.
Ion mobility spectrometry includes the transference tube with Faraday plate receiving pole, and the transference tube close to Faraday plate moves
It moves area one end and is equipped with drift gas entrance, transference tube reaction zone one end far from Faraday plate is equipped with total gas outlet, enters in drift gas
End of the transference tube in the reaction zone of migration area between mouth and total gas outlet, the entrance equipped with sample carrier gas.
End of the transference tube in the reaction zone of migration area between drift gas entrance and total gas outlet, is equipped with and carries
Air inlet with organic agent molecule carrier gas stream, organic agent molecule enter reaction zone by air inlet.
Organic agent molecule used by ion mobility spectrometry is benzene, toluene, ortho-xylene, paraxylene and ethylbenzene.
The power supply for the on-radiation vacuum UV lamp that reagent molecule auxiliary photo-ionisation cation migration spectrum uses is to penetrate
Frequency power.
Sample carrier gas is consistent with reagent molecule carrier gas stream direction in reaction zone, consistent with migration area drift airflow direction.
All gas in transference tube leaves transference tube by total gas outlet.
Carrying sample, reagent molecule and floating the gas of gas is the sky crossed through active carbon, silica gel, molecular sieve filtration
Gas.
The air inlet of reagent molecule and the air inlet of sample carrier gas are at 0 ° of -180 ° of angle on transference tube.
The concentration of organic agent molecule is 10-20ppm in carrier gas containing organic agent molecule.
Advantages of the present invention:
The present invention is filled using reagent molecule auxiliary photo-ionisation cation migration spectral technology and time resolution dynamic dilution sample introduction
It sets, eliminates the interference of humidity in sevoflurane and expiratory air in combined anesthesia, the clinic for realizing Propofol in expiratory air is continuous
On-line monitoring.
Detailed description of the invention
Such as Fig. 1 and Fig. 2, the structural representation of time resolution dynamic dilution sampling device and transference tube that this method is related to
Figure, 1 is expiratory air, and 2 be flow sensor, and 3,5 and 7 be solenoid valve, and 4 be sampling ring, and 6 be sampling pump, and 8 enter for sample carrier gas
Mouthful, 9 be reagent molecule generating device, and 10 be reagent molecule carrier gas inlet, and 11 be Bradbury-Nielsen, and 12 be conduction
Ring, 13 be aperture plate, and 14 be total gas outlet, and 15 be radio frequency powered power supply, and 16 be vacuum UV lamp ionization source, and 17 is high for+5000V
Pressure, 18 be amplifier, and 19 be drift gas entrance.
Wherein Fig. 1 is sampling process, and sample gas is stored in sampling ring under the action of sampling pump, and carrier gas is direct at this time
Into transference tube, sampling time 20s；
Fig. 2 is sample introduction process, switches three solenoid valves while sampling pump stops, and sample carrier gas at this time flows through sampling ring simultaneously
Sample molecule therein is sent into transference tube and is detected, in the process, the concentration quilt of each compound in sampling ring
Dynamic dilution, sample molecule successively enter ionic reaction area, react with the reagent ion in transference tube reaction zone, generate and produce
Object ion is successively separated by migration area, is reached Faraday plate and is detected, sample injection time 10s；
Fig. 3, when reagent molecule is benzene, toluene, ortho-xylene, paraxylene and ethylbenzene, the ion mobility spectrometry of reagent ion
Figure；
Fig. 4, when reagent molecule is benzene, toluene, ortho-xylene, paraxylene and ethylbenzene, the Ion transfer of 3ppbv Propofol
Spectrogram；
Fig. 5, when reagent molecule is toluene, the ion transfer spectrogram of 3ppbv Propofol and sevoflurane；
Fig. 6, when reagent molecule is toluene, the ion transfer spectrogram of 3ppbv Propofol under 0%RH and 100%RH；
Fig. 7, when reagent molecule is toluene, the dynamically track spectrogram of 3ppbv Propofol peak height under 0%RH and 100%RH；
Fig. 8, when reagent molecule is toluene, the quantitation curves of Propofol under 100%RH；
Fig. 9, when reagent molecule is toluene, the time resolution dynamic dilution sample introduction ion mobility spectrometry of Propofol in expiratory air
Figure.
Specific embodiment
The invention discloses a kind of ionic migration spectrum detection methods of Propofol in expiratory air, using reagent molecule fill-in light
It ionizes cation and migrates spectral technology, binding time differentiates dynamic dilution sampling device, eliminates sevoflurane in combined anesthesia and exhales
The interference of humidity in outlet, realizes the detection of Propofol in expiratory air.
Expiratory air 1 is connected through flow sensor 2 with the interface A of the first two-position three way magnetic valve 3 by pipeline, and the one or two
The interface B of three-way magnetic valve 3 is connect with the Single port of sampling ring 4, the another port of sampling ring 4 and the second two-position three way magnetic valve
5 interface A connection, the interface B of the second two-position three way magnetic valve 5 are connect with 6 air inlet of sampling pump；Sample carrier gas inlet 8 passes through
Pipeline is connect with the interface A of third two-position three way magnetic valve 7, the interface B of third two-position three way magnetic valve 7 by pipeline with just from
Sub- mobility spectrometer carrier gas inlet connection；The interface C of the interface C of third two-position three way magnetic valve 7 and the second two-position three way magnetic valve 5
Connection；The interface C of first two-position three way magnetic valve 3 is connect by pipeline with the air inlet of cation mobility spectrometer sample carrier gas；
Reagent molecule carrier gas inlet 10 is by pipeline through reagent molecule generating device 9 and cation mobility spectrometer organic reagent
The air inlet of molecule carrier gas stream connects；
When sampling, expiratory air 1 is connect under the action of sampling pump 6 by flow sensor 2, the first two-position three way magnetic valve 3
Mouth A, 3 interface B of the first two-position three way magnetic valve, sampling ring 4,5 interface A of the second two-position three way magnetic valve, the second two-position three way electricity
5 interface B of magnet valve, sampling pump 6；
Sample carrier gas is through sample carrier gas inlet 8 by pipeline through 7 interface A of third two-position three way magnetic valve, the three or two three
7 interface B of three-way electromagnetic valve and the entrance of cation mobility spectrometer sample carrier gas are directly entered transference tube；
Organic agent molecule carrier gas through reagent molecule carrier gas inlet 10 by pipeline through reagent molecule generating device 9 with just from
The air inlet of sub- mobility spectrometer organic agent molecule carrier gas stream enters transference tube, sampling time 20s；That is sampling process,
Sample gas is stored in sampling ring under the action of sampling pump, and carrier gas at this time is directly entered transference tube, sampling time 20s.
When sample introduction, switch three solenoid valves while sampling pump 6 stops, sample carrier gas (8) is by third two-position three way electricity
7 interface A of magnet valve, third two-position three way magnetic valve (7) interface C, the second two-position three way magnetic valve (5) interface C, the second two-position three way
Solenoid valve (5) interface A, sampling ring (4), the first two-position three way magnetic valve (3) interface B, the first two-position three way magnetic valve (3) interface
C and the entrance of cation mobility spectrometer sample carrier gas are directly entered cation migration spectrum；That is sample introduction process, sampling pump stop same
When switch three solenoid valves, sample carrier gas at this time flow through sampling ring and will sample molecule therein be sent into transference tube in carry out
Detection, in the process, the concentration of each compound successively enters ionic reaction area by dynamic dilution, sample molecule in sampling ring,
It is reacted with the reagent ion in transference tube reaction zone, generates product ion, successively separated by migration area, reach faraday
Disk is detected, sample injection time 10s.
Organic agent molecule carrier gas through reagent molecule carrier gas inlet (10) by pipeline through reagent molecule generating device (9) with
The air inlet of cation mobility spectrometer organic agent molecule carrier gas stream enters transference tube；
Sampling ring (4) is the four fluorine tube (outer diameter 4mm, internal diameter 3mm) of long 150cm, the hollow volume with 10.6ml, temperature
It is constant in 28 DEG C of ranges.
Ion mobility spectrometry is the cation migration spectrum that reagent molecule assists photo-ionisation, and the light ionization source used is on-radiation
Vacuum UV lamp.
Ion mobility spectrometry includes the transference tube with Faraday plate receiving pole, and the transference tube close to Faraday plate moves
It moves area one end and is equipped with drift gas entrance, transference tube reaction zone one end far from Faraday plate is equipped with total gas outlet, enters in drift gas
End of the transference tube in the reaction zone of migration area between mouth and total gas outlet, the entrance equipped with sample carrier gas.
End of the transference tube in the reaction zone of migration area between drift gas entrance and total gas outlet, migration area
Front end is equipped with the air inlet of carrier band organic agent molecule carrier gas stream, and organic agent molecule enters reaction zone by air inlet.
Organic agent molecule used by ion mobility spectrometry is benzene, toluene, ortho-xylene, paraxylene and ethylbenzene.
The power supply of on-radiation vacuum UV lamp used in reagent molecule auxiliary photo-ionisation cation migration spectrum is
Radio-frequency power supply.
Sample carrier gas is consistent with reagent molecule carrier gas stream direction in reaction zone, consistent with migration area airflow direction.
All gas in transference tube leaves transference tube by total gas outlet.
Carrying sample, reagent molecule and floating the gas of gas is successively to cross through active carbon, silica gel, molecular sieve filtration
Air.
The air inlet of reagent molecule and the air inlet of sample carrier gas are at 0 ° of angle on transference tube.
The concentration of organic agent molecule is 15ppm in carrier gas containing organic agent molecule.
If the structural schematic diagram of Fig. 1 and Fig. 2, this method transference tube being related to, 1 is expiratory air, 2 be flow-velocity sensing
Device, 3,5 and 7 be the first, second, third two-position three way magnetic valve (one-in-and-two-out), and 4 be sampling ring, and 6 be sampling pump, and 8 be sample
Carrier gas inlet, 9 be reagent molecule generating device, and 10 be reagent molecule carrier gas inlet, and 11 be Bradbury-Nielsen, and 12 are
Conducting ring, 13 be aperture plate, and 14 be total gas outlet, and 15 be radio frequency powered power supply, and 16 be vacuum UV lamp ionization source, and 17 be+5000V
High pressure, 18 be amplifier, and 19 be drift gas entrance；
Wherein Fig. 1 is sampling process, and sample gas is stored in sampling ring under the action of sampling pump, and carrier gas is direct at this time
Into transference tube, sampling time 20s.
Fig. 2 is sample introduction process, switches three solenoid valves while sampling pump stops, and sample carrier gas at this time flows through sampling ring simultaneously
Sample molecule therein is sent into transference tube and is detected, in the process, the concentration quilt of each compound in sampling ring
Dynamic dilution, sample molecule successively enter ionic reaction area, react with the reagent ion in transference tube reaction zone, generate and produce
Object ion is successively separated by migration area, is reached Faraday plate and is detected, sample injection time 10s.
Fig. 3, when reagent molecule is benzene, toluene, ortho-xylene, paraxylene and ethylbenzene, the ion mobility spectrometry of reagent ion
Figure.
Fig. 4, when reagent molecule is benzene, toluene, ortho-xylene, paraxylene and ethylbenzene, the Ion transfer of 3ppbv Propofol
Spectrogram.
Fig. 5, when reagent molecule is toluene, the ion transfer spectrogram of 3ppbv Propofol and sevoflurane.
Fig. 6, when reagent molecule is toluene, the ion transfer spectrogram of 3ppbv Propofol under 0%RH and 100%RH.
Fig. 7, when reagent molecule is toluene, the dynamically track spectrogram of 3ppbv Propofol peak height under 0%RH and 100%RH.
Fig. 8, when reagent molecule is toluene, the quantitation curves of Propofol under 100%RH.
Fig. 9, when reagent molecule is toluene, the time resolution dynamic dilution sample introduction ion mobility spectrometry of Propofol in expiratory air
Figure.
Embodiment 1
Photo-ionisation cation migration spectrum is assisted using reagent molecule, wherein reagent molecule is respectively benzene, toluene, adjacent diformazan
When benzene, paraxylene and ethylbenzene, their reagent ion reduction mobility is respectively 2.22,2.07,1.95,1.96 and
1.96cm2V-1s-1, as shown in Figure 3.
Embodiment 2
3ppbv Propofol is detected using reagent molecule auxiliary photo-ionisation cation migration spectrum, wherein reagent molecule is respectively
When benzene, toluene, ortho-xylene, paraxylene and ethylbenzene, the reduction mobility of Propofol product ion is 1.50cm2V-1s-1,
As shown in Figure 4.
Embodiment 3
3ppbv Propofol and sevoflurane, pilot scale are detected simultaneously using reagent molecule auxiliary photo-ionisation cation migration spectrum
When agent molecule is toluene, the reduction mobility of toluene reagent ion is 2.07cm2V-1s-1, the reduction at Propofol product ion peak moves
Shifting rate is 1.50cm2V-1s-1, sevoflurane do not have signal response, and the dry of sevoflurane in combined anesthesia is eliminated under positive ion mode
It disturbs, as shown in Figure 5.
Embodiment 4
Photo-ionisation cation migration spectrum is assisted using reagent molecule, binding time differentiates the detection of dynamic dilution sampling device
The Propofol of 3ppbv under 0%RH and 100%RH, as shown in fig. 6, the product ion of Propofol is not affected by humidity, reduction is moved
Shifting rate is 1.50cm2V-1s-1Product ion peak.
Embodiment 5
Photo-ionisation cation migration spectrum is assisted using reagent molecule, binding time differentiates the detection of dynamic dilution sampling device
The Propofol of 3ppbv under 0%RH and 100%RH, as shown in fig. 7, being the dynamically track spectrogram of 0%RH and 100%RH, using every
During a 10s sample introduction, the maximum signal of Propofol quantifies it, wherein Propofol peak signal is strong under 0%RH
The relative standard deviation of degree is that the relative standard deviation of Propofol maximum signal under 0.48%, 100%RH is 0.98%, is shown
Good repeatability is shown.
Embodiment 6
Photo-ionisation cation migration spectrum is assisted using reagent molecule, binding time differentiates the detection of dynamic dilution sampling device
The Propofol of various concentration under 100%RH, obtains the quantitation curves of Propofol under 100%RH, as shown in figure 8, linear equation are as follows:
Y=61.83x+87.37, wherein x is the concentration (ppbv) of Propofol, and y is that the peak signal during Propofol 10s sample introduction is strong
It spends (mV), R2=0.99, there is preferable correlation, range of linearity 0.2-16ppbv, detection is limited to 26pptv.
Embodiment 7
Photo-ionisation cation migration spectrum is assisted using reagent molecule, binding time is differentiated the detection of dynamic dilution sampling device and exhaled
Propofol in outlet, the difference of the adsorptivity in tetrafluoro sampling ring due to propofol molecule in expiratory air and hydrone, into
In the 1s of sample process, the hydrone in expiratory air, which first dilutes, to be come out, and 2s Propofol dilutes out, and it is strong to reach peak signal
Degree, it is quantitative using the signal strength of 2s Propofol, to eliminate the influence of humidity in expiratory air, as shown in Figure 9.
Claims (10)
1. the cation of Propofol migrates spectrum detection method in a kind of expiratory air, it is characterised in that:
1) sampling process, sample gas is stored in sampling ring under the action of sampling pump, and carrier gas is directly entered Ion transfer at this time
Pipe, sampling time 10-20s；
2) sample introduction process, switches three solenoid valves while sampling pump stops, sample carrier gas at this time flows through sampling ring and will wherein
Sample molecule be sent into transference tube in detected, in the process, in sampling ring each compound concentration by dynamic it is dilute
Release, sample molecule successively enters ionic reaction area, reacted with the reagent ion in transference tube reaction zone, generate product from
Son is successively separated by migration area, is reached Faraday plate and is detected, sample injection time 10-15s.
2. analysis method according to claim 1, it is characterised in that:
Expiratory air (1) is connected through flow sensor (2) with the interface A of the first two-position three way magnetic valve (3) by pipeline, and the one or two
The interface B of position-3-way solenoid valve (3) is connect with the Single port of sampling ring (4), the another port of sampling ring (4) with the two or two three
The interface B of the interface A connection of three-way electromagnetic valve (5), the second two-position three way magnetic valve (5) is connect with sampling pump (6) air inlet；Sample
Carrier gas inlet (8) is connect by pipeline with the interface A of third two-position three way magnetic valve (7), third two-position three way magnetic valve (7)
Interface B is connect by pipeline with cation mobility spectrometer carrier gas inlet；The interface C and second of third two-position three way magnetic valve (7)
The interface C connection of two-position three way magnetic valve (5)；The interface C of first two-position three way magnetic valve (3) is migrated by pipeline and cation
The air inlet of spectrometer sample carrier gas connects；
Reagent molecule carrier gas inlet (10) is by pipeline through reagent molecule generating device (9) and cation mobility spectrometer organic reagent
The air inlet of molecule carrier gas stream connects；
When sampling, flow sensor (2), the first two-position three way magnetic valve are passed through in expiratory air (1) under the action of sampling pump (6)
(3) interface A, the first two-position three way magnetic valve (3) interface B, sampling ring (4), the second two-position three way magnetic valve (5) interface A, second
Two-position three way magnetic valve (5) interface B, sampling pump (6)；
Sample carrier gas through sample carrier gas inlet (8) by pipeline through third two-position three way magnetic valve (7) interface A, the three or two three
Three-way electromagnetic valve (7) interface B and the entrance of cation mobility spectrometer sample carrier gas are directly entered transference tube；
Organic agent molecule carrier gas through reagent molecule carrier gas inlet (10) by pipeline through reagent molecule generating device (9) with just from
The air inlet of sub- mobility spectrometer organic agent molecule carrier gas stream enters transference tube, sampling time 10-20s；
When sample introduction, switch three solenoid valves while sampling pump (6) stops, third two-position three-way electromagnetic is passed through in sample carrier gas (8)
Valve (7) interface A, third two-position three way magnetic valve (7) interface C, the second two-position three way magnetic valve (5) interface C, the second two-position three way
Solenoid valve (5) interface A, sampling ring (4), the first two-position three way magnetic valve (3) interface B, the first two-position three way magnetic valve (3) interface
C and the entrance of cation mobility spectrometer sample carrier gas are directly entered cation migration spectrum；
Organic agent molecule carrier gas through reagent molecule carrier gas inlet (10) by pipeline through reagent molecule generating device (9) with just from
The air inlet of sub- mobility spectrometer organic agent molecule carrier gas stream enters transference tube；
Sampling ring (4) is the four fluorine tube (outer diameter 4mm, internal diameter 3mm) of long 150cm, has the hollow volume of 10.6ml, and temperature is constant
In 25-30 DEG C of range.
3. analysis method according to claim 1, it is characterised in that:
Ion mobility spectrometry is the cation migration spectrum that reagent molecule assists photo-ionisation, and the light ionization source used (1) is on-radiation
Vacuum UV lamp, the lamp be commercialization low pressure Kr gas discharge lamp (Kr10.6-B12X50PID lamp, Steven
Sepvest Corporation), the main photon for generating 10.0eV and 10.6eV, light intensity is about 5 × 1011Photons/s,
The photon intensity that the photon intensity of middle 10.0eV accounts for 80%, 10.6eV accounts for 20%.
4. analysis method according to claim 3, it is characterised in that:
Ion mobility spectrometry includes the transference tube with Faraday plate receiving pole, close to the transference tube migration area of Faraday plate
One end is equipped with drift gas entrance (19), and transference tube reaction zone one end far from Faraday plate is equipped with total gas outlet (14), in drift
Transference tube between gas entrance (19) and total gas outlet (14) is close to the reaction zone end of migration area, equipped with sample carrier gas
Entrance；
Transference tube between drift gas entrance (19) and total gas outlet (14) is equipped with and carries close to the reaction zone end of migration area
Air inlet with organic agent molecule carrier gas stream, organic agent molecule enter reaction zone by air inlet.
5. analysis method according to claim 3, it is characterised in that:
Organic agent molecule used by ion mobility spectrometry is benzene, toluene, ortho-xylene, paraxylene and ethylbenzene.
6. analysis method according to claim 3, it is characterised in that:
The power supply for the on-radiation vacuum UV lamp that reagent molecule auxiliary photo-ionisation cation migration spectrum uses is radio frequency electrical
Source.
7. analysis method according to claim 4, it is characterised in that:
Sample carrier gas is consistent with reagent molecule carrier gas stream direction in reaction zone, consistent with migration area drift gas airflow direction；
All gas in transference tube leaves transference tube by total gas outlet (14).
8. according to analysis method described in claim 4 and 7, it is characterised in that:
The sample carrier gas, reagent molecule carrier gas and to float the gas of gas be through one in active carbon, silica gel or molecular sieve
Kind or two or more filtered air.
9. analysis method according to claim 4, it is characterised in that:
Reagent molecule air inlet and the air inlet of sample carrier gas are at 0 ° of -180 ° of angle on transference tube.
10. analysis method according to claim 5, it is characterised in that:
The concentration of organic agent molecule is 10-20ppm in gas of carrier gas containing organic agent molecule.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111024798A (en) * | 2019-12-12 | 2020-04-17 | 天津科技大学 | System and method for automatically monitoring environment dimethyl sulfur on line |
| CN112924527A (en) * | 2019-12-06 | 2021-06-08 | 中国科学院大连化学物理研究所 | Method for improving detection sensitivity of exhaled propofol |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008003046A (en) * | 2006-06-26 | 2008-01-10 | Tomiyoshi Kazama | Device for measuring intravenous anesthetic blood concentration |
| CN102478544A (en) * | 2010-11-30 | 2012-05-30 | 中国科学院大连化学物理研究所 | Novel method for identifying and detecting explosive |
| CN103868974A (en) * | 2012-12-12 | 2014-06-18 | 中国科学院大连化学物理研究所 | Method for detecting No and/or propofol in expiratory gas |
| CN103884771A (en) * | 2012-12-21 | 2014-06-25 | 中国科学院大连化学物理研究所 | Accurate method for detecting propofol anesthetic in blood |
| CN105092689A (en) * | 2014-05-20 | 2015-11-25 | 中国科学院大连化学物理研究所 | Real time on-line expired air monitor |
| CN105628783A (en) * | 2014-10-28 | 2016-06-01 | 中国科学院大连化学物理研究所 | Application of reagent molecules in ion mobility spectrometry detection of explosive peroxide HMTD |
| WO2017095921A1 (en) * | 2015-11-30 | 2017-06-08 | Concordia University Inc. | Compositions for cyp450 phenotyping using saliva samples |
| CN106841365A (en) * | 2015-12-07 | 2017-06-13 | 中国科学院大连化学物理研究所 | A kind of online high speed detection method of ammonia |
| CN106841367A (en) * | 2015-12-07 | 2017-06-13 | 中国科学院大连化学物理研究所 | A kind of Ion transfer spectrum detection method of time resolution Dynamic Thermal parsing |
| CN106872553A (en) * | 2015-12-14 | 2017-06-20 | 中国科学院大连化学物理研究所 | A kind of Propofol detection method for eliminating sevoflurane interference |
-
2017
- 2017-11-13 CN CN201711115009.7A patent/CN109781827A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008003046A (en) * | 2006-06-26 | 2008-01-10 | Tomiyoshi Kazama | Device for measuring intravenous anesthetic blood concentration |
| CN102478544A (en) * | 2010-11-30 | 2012-05-30 | 中国科学院大连化学物理研究所 | Novel method for identifying and detecting explosive |
| CN103868974A (en) * | 2012-12-12 | 2014-06-18 | 中国科学院大连化学物理研究所 | Method for detecting No and/or propofol in expiratory gas |
| CN103884771A (en) * | 2012-12-21 | 2014-06-25 | 中国科学院大连化学物理研究所 | Accurate method for detecting propofol anesthetic in blood |
| CN105092689A (en) * | 2014-05-20 | 2015-11-25 | 中国科学院大连化学物理研究所 | Real time on-line expired air monitor |
| CN105628783A (en) * | 2014-10-28 | 2016-06-01 | 中国科学院大连化学物理研究所 | Application of reagent molecules in ion mobility spectrometry detection of explosive peroxide HMTD |
| WO2017095921A1 (en) * | 2015-11-30 | 2017-06-08 | Concordia University Inc. | Compositions for cyp450 phenotyping using saliva samples |
| CN106841365A (en) * | 2015-12-07 | 2017-06-13 | 中国科学院大连化学物理研究所 | A kind of online high speed detection method of ammonia |
| CN106841367A (en) * | 2015-12-07 | 2017-06-13 | 中国科学院大连化学物理研究所 | A kind of Ion transfer spectrum detection method of time resolution Dynamic Thermal parsing |
| CN106872553A (en) * | 2015-12-14 | 2017-06-20 | 中国科学院大连化学物理研究所 | A kind of Propofol detection method for eliminating sevoflurane interference |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112924527A (en) * | 2019-12-06 | 2021-06-08 | 中国科学院大连化学物理研究所 | Method for improving detection sensitivity of exhaled propofol |
| CN111024798A (en) * | 2019-12-12 | 2020-04-17 | 天津科技大学 | System and method for automatically monitoring environment dimethyl sulfur on line |
| CN111024798B (en) * | 2019-12-12 | 2023-04-28 | 天津科技大学 | System and method for automatically monitoring environment dimethyl sulfide on line |
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