CN206725500U - A kind of blood concentration assay instrument detecting system - Google Patents
A kind of blood concentration assay instrument detecting system Download PDFInfo
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- CN206725500U CN206725500U CN201621249138.6U CN201621249138U CN206725500U CN 206725500 U CN206725500 U CN 206725500U CN 201621249138 U CN201621249138 U CN 201621249138U CN 206725500 U CN206725500 U CN 206725500U
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Abstract
A kind of blood concentration assay instrument detecting system, including transference tube are the utility model is related to, transference tube includes the light ionization source and Faraday plate positioned at its both ends, and ionized region, migration area are followed successively by Faraday plate side close to light ionization source；In ionized region sample gas carrier gas inlet is provided with close to the transference tube side wall of light ionization source, transference tube offgas outlet is provided with transference tube side wall of the ionized region at migration area, drift gas entrance is provided with close to the transference tube side wall of Faraday plate in migration area；Chemical dopant entrance is provided with close to the transference tube side wall of light ionization source in ionized region, sample gas carrier gas inlet is oppositely arranged with chemical dopant entrance.Detection means in the utility model, chemical doping agent concentration is effectively controlled between 1 10ppm.Sampling device uses pulsed input mode, substantially increases detection sensitivity.
Description
Technical field
The utility model belongs to blood drug concentration analysis detecting system field, and this detecting system is based on ion mobility spectrometry skill
Art, and in particular to blood drug concentration analyzing detecting method after clinician is administered.Detecting system in the utility model is led to
Cross and use light ionization source, by changing chemical dopant addition manner and regulation chemical doping agent concentration, and strobe pulse sample introduction
Mode, substantially increase detection sensitivity.Clinical administration depth analysis is can be widely used for, instructs the accurate medication of clinician.
Background technology
Blood concentration real-time dynamic monitoring is that research medicine is studied patient's body mechanism of action and accurate medication
Crucial, difficulties, real-time, online effective analysis means are there is no both at home and abroad.Therapeutic drug monitoring home and abroad uses color at present
Spectrometry and mass spectrography, because these methods monitor time-consuming, laborious, complex pretreatment, so also only some are reported both at home and abroad,
With less in clinical practice.Detecting system in the present invention is to be based on Ion mobility spectrometry, with reference to vacuum ultraviolet ionized
Technology, avoid63The radioactive pollution in Ni sources.But because light ionization source is unstable, chemical dopant is not easy addition and concentration
It is whard to control.At present its detection sensitivity or some do not reach requirement.
Ion mobility spectrometry (Ion Mobility Spectrometry, IMS) technology is the one kind occurred the 1970s
Quick separating detection technique, compared with traditional mass spectrum, chromatographic apparatus, have it is simple in construction, high sensitivity, analyze speed is fast,
The characteristics of reliable results.The IMS that we study at present has been widely used in multiple fields.Ionic migration spectrometer core component master
To be made up of ionization source, ion gate, migration area and detector.Ion gun makes sample molecule, N2、O2Ionize, produce with vapor
Ion be easy to molecule occur ion molecule reaction, obtain multi-products ion.Ion passes through week under the driving of electric field
The ion gate that phase property is opened enters migration area, is continually colliding with neutral drift qi leel of adverse current, because these ions are in electric field
In there is different migration rates so that different ions are separated, and successively reach detector.Significantly, since
Difference of the different compounds in the chemical property such as ionization energy, proton affinity, electronegativity, it is electric in atmospheric pressure ionization source
From when to produce the efficiency of positive and negative polar ion different with selectivity.
In order to reduce tradition63Ni ionization sources produce the risk of radioactive pollution in clinical practice, are easy in operating room existing
The security and clinic of field application are widely applied, and the design of ionization source is using the photoelectricity based on on-radiation in this detecting system
From source.In the design in atmospheric pressure photoionization source, ionization is improved by the way of dopant (Dopant) is added into ionization source
Efficiency and selectivity.Chemical dopant (such as acetone, butanone) molecule of the photon ionization high concentration of light ionization source transmitting, is produced
Substantial amounts of photoelectron and chemical dopant cation.In atmospheric environment, these photoelectrons and dopant cation can pass through one
Sequence of ion-molecule reaction produces the reagent ion of different positive and negative polarity.Then, these reagent ions and anesthetic to be measured point
Effectively ionized by chemi-ionization reaction between son, produce the characteristic ion of respective opposed polarity, and eventually through bimodulus
Transference tube realizes separation and detection according to the different of mobility.
Utility model content
The purpose of this utility model is：It is lower slightly not to overcome prior art optical ionization ion mobility to compose detection sensitivity
Foot, a kind of blood concentration assay instrument detecting system based on Ion mobility spectrometry is proposed, have that analysis detection speed is fast, structure
Simply, small volume and the characteristics of be easy to carry, detection sensitivity is improved, and has met clinical practice demand；
A kind of blood concentration assay instrument detecting system, including transference tube, transference tube are included positioned at its both ends
Light ionization source and Faraday plate, ionized region, migration area are followed successively by Faraday plate side close to light ionization source；In ionized region close to light
The transference tube side wall of ionization source is provided with sample gas carrier gas inlet, in transference tube side of the ionized region at migration area
Wall is provided with transference tube offgas outlet, and being provided with drift gas close to the transference tube side wall of Faraday plate in migration area enters
Mouthful；
In ionized region chemical dopant (dopant) entrance, sample are provided with close to the transference tube side wall of light ionization source
Product gas carrier gas inlet is oppositely arranged with chemical dopant (dopant) entrance.
Magnetic valve is provided with the sample gas carrier gas inlet pipeline outside transference tube；In the sample gas outside transference tube
Carrier gas inlet pipeline is provided with the branch line being connected with air, and magnetic valve is provided with branch line.
Including：Medical air, gas source purification device, thermal desorption sampling device transference tube；
Integrated connection relation is：Medical air is connected with gas source purification device by converting interface；Along airflow direction, source of the gas
Include molecular sieve purification device, activated-charcoal purifier, pressure-reducing valve, the organic filtration device contacted successively in purifier, source of the gas is net
The clean source of the gas that outflow is put in makeup divides the flow into three tunnels by gas circuit shunting connection three-way connection, respectively through mass flow controller
Flow is controlled, is connected all the way through chemical dopant bottle with chemical dopant (dopant) entrance, this road gas is chemical dopant
Gas entrance；Second tunnel is divided into two-way A and B, A road after thermal desorption sampling device and is connected through magnetic valve with sample gas carrier gas inlet,
Sample gas is analyzed through this mouth into migration tube, and B roads are connected through magnetic valve with air, and this is that sample gas shunting exports, redundant sample
Gas removes through this separation panel；3rd tunnel is connected with drift gas entrance.
Transference tube offgas outlet is connected with device for absorbing tail gas.
Transference tube dopant gas entrance and sample gas carrier gas inlet are located at adjacent two electrode retaining collar of transference tube respectively
Between opposite sides be located at reaction zone.
The advantages of the utility model, is as follows：
1. compared with traditional chromatographic process, an independent detecting system is formed with reference to Medical air.Analysis detection speed
The characteristics of spending fast, simple in construction, small volume and being easy to carry, can meet clinical application on site.
2. compared with the Ion mobility spectrometry of routine, optical ionization ion mobility pipe is selected, chemistry is added into ionization source
Dopant, individually gas enters migration tube reaction zone, stable control concentration of dopant to chemical dopant all the way, it is possible to achieve accurate
Quantitative analysis.
3. compared with the Thermal desorption technology of routine, before this detecting system thermal desorption sampling device enters migration tube, pass through gas
Two magnetic valves in parallel, take intermittent impulse sampling technique in road, realize example enrichment and redundant sample shunting, improve detection
Sensitivity, and avoid the residual of sample gas in detecting system.
Brief description of the drawings
Fig. 1 is a kind of blood concentration assay instrument detecting system schematic diagram；1 is light ionization source, and 2 be chemical dopant
(dopant) entrance, 3 be sample gas carrier gas inlet, and 4 be drift gas entrance, and 5 be transference tube offgas outlet, and 6 be medical air
Source, 7 be Medical air and gas source purification device converting interface, and 8 be gas source purification device, and 9,10,25 be gas circuit shunting connection threeway
Joint, 14,15,16 be respectively mass flow controller, and 11,12,13 be respectively mass flow controller air source inlet, and 17 be change
Dopant bottle is learned, 18 be chemical dopant air flow inlet, and 19 be thermal desorption sampling device, and 20 be thermal desorption sampling device carrier gas
Entrance, 21,26 be magnetic valve, and 22 be that sample gas exports through thermal desorption sampling device flow export, 23 for sample gas shunting, and 24 are
Sample gas is through two three-way electromagnetic valve flow exports, and 27 be device for absorbing tail gas, and 28 be Faraday plate, and 29 be signal reception and data processing
Device.
Fig. 2 is the ion transfer spectrogram that the different addition manners of chemical dopant (chemical dopant is acetone) are formed；
Fig. 3 is continuous or interval sample detection 2.5ppm Propofol ion mobility spectrometry Thermal desorption figures；
Embodiment
A kind of blood concentration assay instrument detecting system, including：Medical air 6, gas source purification device 8, Thermal desorption sample introduction dress
Put 19, transference tube 1-5, chemical dopant bottle 17, gas circuit gas flow control device 14-16, signal and receive and handle dress
Put 28, high-pressure modular and control system device.Transference tube offgas outlet 5 is connected with device for absorbing tail gas 27.
Transference tube signal receives and processing unit module 29 is responsible for whole detecting system signal output and processing, including
The signal amplifier of connection, A/D converter successively, PC processors, signal amplifier are connected with the signal of Faraday plate 28.
Chemical dopant (dopant) entrance 2 is provided with close to the transference tube side wall of light ionization source 1 in ionized region,
Sample gas carrier gas inlet 3 is oppositely arranged with chemical dopant (dopant) entrance 2.
Magnetic valve is provided with the pipeline of sample gas carrier gas inlet 3 outside transference tube；In the sample outside transference tube
The pipeline of gas carrier gas inlet 3 is provided with the branch line being connected with air, and magnetic valve is provided with branch line.Thermal desorption sample introduction fills
Put and detection sensitivity is improved by pulsed interval sample introduction.
Embodiment 1
Chemical dopant (dopant) addition manner conventional method is to add sample gas carrier gas inlet 3, but pyrolysis every time
Analyse injector and open sample introduction moment chemical dopant almost through injection port blowout system, cause the reduction of chemical doping agent concentration,
But chemical doping agent concentration is related to detection sensitivity.
Method is provided with chemical dopant in ionized region close to the transference tube side wall of light ionization source 1 in the present invention
(dopant) entrance 2, sample gas carrier gas inlet 3 are oppositely arranged with chemical dopant (dopant) entrance 2.Pass through chemical doping
Agent independent control is added directly into ionized region, and injector opens sample introduction moment dopant concentration and is almost constant.
Fig. 2 is that chemical dopant is the ion transfer spectrogram that acetone difference addition manner is formed；Chemical dopant is acetone
During 1ppm, two kinds of sample injection methods, acetone signal when Fig. 2 (left side) is the method detection injector unlatching in the present invention, Fig. 2 are selected
(right side) is acetone signal when traditional sample injection method detection injector is opened.Method detects in the present invention when other conditions are identical
Acetone signal (>4500mv) intensity is significantly stronger than the signal (600mv) that traditional technique in measuring arrives.But photo-ionisation ion moves
Spectrum is moved, acetone concentration enhancing is advantageous for improving detection sensitivity.
Embodiment 2
The second road gas that Medical air is formed is divided into two-way A and B, A road through magnetic valve after thermal desorption sampling device (19)
It is connected with sample gas carrier gas inlet 3, sample gas is analyzed through this mouth into migration tube.B roads are connected through magnetic valve with air, and this is sample
Product qi leel flow export, redundant sample gas remove through this separation panel；
Sample gas enters before transference tube, and two closed electromagnetic valve 3S, Thermal desorption sample introduction are controlled during sample Thermal desorption
Example enrichment in device；After 3S, A roads connection magnetic valve is opened, B roads connection closed electromagnetic valve, sample introduction 6S；After 6S, the connection of A roads
Closed electromagnetic valve, B roads connection magnetic valve are opened, and redundant sample gas avoids residual interference from influenceing quantitative point through B roads SHUNT state
Analysis.
Fig. 3 is continuous or interval sample detection 2.5ppm Propofol ion mobility spectrometry Thermal desorption figures；Fig. 3 (left side) is traditional
The Thermal desorption ion transfer spectrogram of Propofol in direct injected method detection 2.5ppm blood；Fig. 3 (right side) is above-mentioned in the present invention
The Thermal desorption ion transfer spectrogram of Propofol in pulse spacing sample injection method detection 2.5ppm blood.Fig. 3 (left side) signal adds and is
800mv, Fig. 3 (right side) signal adds and is 2370mv, and detection signal strengthens 3 times.
Claims (5)
1. a kind of blood concentration assay instrument detecting system, including transference tube, transference tube includes the light positioned at its both ends
Ionization source (1) and Faraday plate (28), ionized region, migration area are followed successively by Faraday plate (28) side close to light ionization source (1)；In
Ionized region is provided with sample gas carrier gas inlet (3) close to the transference tube side wall of light ionization source (1), in ionized region close to migration
Transference tube side wall at area is provided with transference tube offgas outlet (5), is moved in migration area close to the ion of Faraday plate
Move pipe side wall and be provided with drift gas entrance (4)；It is characterized in that：
In ionized region chemical dopant entrance (2), sample gas carrier gas are provided with close to the transference tube side wall of light ionization source (1)
Entrance (3) is oppositely arranged with chemical dopant entrance (2).
2. blood concentration assay instrument detecting system according to claim 1, it is characterised in that：In the sample outside transference tube
Product gas carrier gas inlet (3) pipeline is provided with magnetic valve；In sample gas carrier gas inlet (3) pipeline outside transference tube be provided with
The connected branch line of air, magnetic valve is provided with branch line.
3. blood concentration assay instrument detecting system according to claim 1, it is characterised in that：Including：Medical air (6),
Gas source purification device (8), thermal desorption sampling device (19), transference tube；
Integrated connection relation is：Medical air (6) is connected with gas source purification device (8) by converting interface (7)；Along air-flow side
To molecular sieve purification device, activated-charcoal purifier, pressure-reducing valve, organic filtration including contacting successively in gas source purification device (8)
Device, the clean source of the gas of gas source purification device (8) outflow shunts connection three-way connection by gas circuit and divides the flow into three tunnels, respectively through matter
Flow controller control flow is measured, is connected all the way through chemical dopant bottle (17) with chemical dopant entrance (2), this road gas is
Chemical dopant bottle air flow inlet；Second tunnel is divided into two-way A and B, A road through magnetic valve and sample after thermal desorption sampling device (19)
Product gas carrier gas inlet (3) is connected, and sample gas is analyzed through this mouth into migration tube, and B roads are connected through magnetic valve with air, and this is sample
Qi leel flow export, redundant sample gas remove through this separation panel；3rd tunnel is connected with drift gas entrance.
4. blood concentration assay instrument detecting system according to claim 1, it is characterised in that：Transference tube offgas outlet
(5) it is connected with device for absorbing tail gas (27).
A kind of 5. blood concentration assay instrument detecting system according to claim 1, it is characterised in that：Transference tube chemistry
Dopant bottle air flow inlet and sample gas carrier gas inlet are located at the opposite sides of the adjacent two electrodes interannular of transference tube respectively
In reaction zone.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201621249138.6U CN206725500U (en) | 2016-11-17 | 2016-11-17 | A kind of blood concentration assay instrument detecting system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201621249138.6U CN206725500U (en) | 2016-11-17 | 2016-11-17 | A kind of blood concentration assay instrument detecting system |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108072694A (en) * | 2016-11-17 | 2018-05-25 | 中国科学院大连化学物理研究所 | A kind of blood concentration assay instrument detecting system |
| CN111105981A (en) * | 2018-10-25 | 2020-05-05 | 中国科学院大连化学物理研究所 | Flash thermal desorption-pulse sampling method for rapid and high-sensitivity detection of drugs on site |
| CN112485321A (en) * | 2020-11-24 | 2021-03-12 | 中国科学院大连化学物理研究所 | Ion mobility spectrometry determination method for content of ammonia gas in ammonia-containing gas |
| CN112903803A (en) * | 2019-11-19 | 2021-06-04 | 中国科学院大连化学物理研究所 | Device and method for improving detection sensitivity of etomidate blood concentration in operation |
-
2016
- 2016-11-17 CN CN201621249138.6U patent/CN206725500U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108072694A (en) * | 2016-11-17 | 2018-05-25 | 中国科学院大连化学物理研究所 | A kind of blood concentration assay instrument detecting system |
| CN111105981A (en) * | 2018-10-25 | 2020-05-05 | 中国科学院大连化学物理研究所 | Flash thermal desorption-pulse sampling method for rapid and high-sensitivity detection of drugs on site |
| CN112903803A (en) * | 2019-11-19 | 2021-06-04 | 中国科学院大连化学物理研究所 | Device and method for improving detection sensitivity of etomidate blood concentration in operation |
| CN112485321A (en) * | 2020-11-24 | 2021-03-12 | 中国科学院大连化学物理研究所 | Ion mobility spectrometry determination method for content of ammonia gas in ammonia-containing gas |
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