CN109781821B - Blood sugar detector - Google Patents
Blood sugar detector Download PDFInfo
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- CN109781821B CN109781821B CN201711106009.0A CN201711106009A CN109781821B CN 109781821 B CN109781821 B CN 109781821B CN 201711106009 A CN201711106009 A CN 201711106009A CN 109781821 B CN109781821 B CN 109781821B
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- 238000001514 detection method Methods 0.000 claims abstract description 58
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 25
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- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The invention provides a blood sugar detector which comprises a blood sample acquisition device, a blood sugar detection device, a data storage, a reminding device and a detection report printing device, wherein the blood sample acquisition device, the blood sugar detection device and the reminding device are sequentially connected, the blood sugar detection device, the data storage and the detection report printing device are sequentially connected, the blood sugar detection device comprises a biosensor and a main control unit, the biosensor is connected with the main control unit, the biosensor comprises a chip bottom plate, and an oxygen electrode, a PH value detection electrode, a hydrogen peroxide electrode, a PH value detection signal output contact, a hydrogen peroxide signal output contact and an oxygen signal output contact which are arranged on the chip bottom plate, and a plurality of connecting lines. The measuring angle of the detector can be remarkably improved.
Description
Technical Field
The invention relates to the technical field of medical detection equipment.
Background
The incidence of diabetes also has a tendency to generalize and younger over time. Diabetes is a chronic disease with a long therapeutic period, and requires frequent monitoring of blood glucose concentration in the body and injection of insulin to regulate blood glucose concentration. Most of the existing blood glucose meters have single functions.
A biosensor (bio sensor) is a sensor that uses a bio molecule as a recognition element, and specifically recognizes a target and converts the target into signals such as light, electricity, and mass to detect various biological or chemical substances. The biosensor mainly comprises a biomolecule identifying element and a signal converter. The biomolecule-recognition element is a bioactive substance that has molecular recognition capabilities and is in direct contact with the substance to be measured. Depending on the biological recognition element, the biological sensor may be classified into an enzyme sensor, an immunosensor, a nucleic acid sensor, a microbial sensor, a cell sensor, a biomimetic sensor, and the like; the signal converter mainly comprises an electrochemical, an optical detection element, a thermistor, a field effect transistor, a piezoelectric quartz crystal, a surface plasma resonance device and the like. Depending on the transducer, the biosensors are classified into an optical biosensor, an electrochemical biosensor, and a mass biosensor, a heat-measuring type biosensor, an acoustic-measuring type biosensor, and the like. The biosensor can detect the presence of the analyte and quantitatively analyze the content level thereof.
The biosensor detects an analytical device of the target object by means of interactions of biomolecules with the target object molecules. The biosensor may detect the presence of a target molecule in a relatively short period of time compared to culture (PCR) or Polymerase Chain Reaction (PCR). Some biosensors use immunochromatography (immunochromatography) technology. However, this immunochromatography-based biosensor has a problem of adoptive (addition). For example, most immunochromatography-based biosensors detect antibodies (antibodies) raised by patients after a later stage of infection/disease.
The biosensor has great application potential in the fields of clinical examination, food safety, environmental monitoring, national defense and the like by the unique advantages of rapidness, sensitivity, high efficiency, portability, easiness in automation and the like. For many years, academia and industry have been striving to develop biosensors with high sensitivity and high selectivity, and methods for detecting proteins, nucleic acids, cells or small molecules with high sensitivity by using the biosensors have been developed and used for detecting disease markers, environmental toxicants, food contamination, immediate monitoring of biological warfare agents, etc., for example, in medicine, the biosensors can be used for monitoring blood glucose levels of diabetics, detecting pathogens, diagnosing and monitoring cancers; in the field of environmental monitoring, the biosensor can be used for detecting harmful bacteria, heavy metals, pesticides and the like in air, water or food; in the military anti-terrorism field, biosensors can detect chemical and biological toxic molecules to avoid potential contact or infection. Such biosensors exhibit ultra-high sensitivity and reliable selectivity, both in undoped substrates and in complex contexts. However, current biosensor development still suffers from certain limitations, especially in terms of rapid detection on site.
In conclusion, the biosensor in the prior art has lower detection accuracy.
Disclosure of Invention
The invention provides a blood glucose detector, which comprises a blood sample acquisition device, a blood glucose detection device, a data storage, a reminding device and a detection report printing device, wherein the blood sample acquisition device, the blood glucose detection device and the reminding device are sequentially connected, the blood glucose detection device, the data storage and the detection report printing device are sequentially connected, the blood glucose detection device comprises a biosensor and a main control unit, the biosensor is connected with the main control unit, the biosensor comprises a chip bottom plate, and an oxygen electrode, a PH value detection electrode, a hydrogen peroxide electrode, a PH value detection signal output contact, a hydrogen peroxide signal output contact and an oxygen signal output contact which are arranged on the chip bottom plate, and a plurality of connecting lines, wherein the oxygen electrode, the PH value detection electrode and the hydrogen peroxide electrode are respectively and electrically connected with the PH value detection signal output contact, the hydrogen peroxide signal output contact and the oxygen signal output contact through the connecting lines.
Preferably, the chip base plate is a ceramic substrate, and the oxygen electrode, the PH value detection electrode, the hydrogen peroxide electrode, the PH value detection signal output contact, the hydrogen peroxide signal output contact, the oxygen signal output contact and the connection circuit are formed by etching.
Preferably, the oxygen electrode, the PH value detection electrode and the hydrogen peroxide electrode are covered with the glucose oxidase with the protective permeable membrane and biological activity.
Preferably, the PH value detection signal output contact, the hydrogen peroxide signal output contact and the oxygen signal output contact are metal contacts.
Preferably, the oxygen electrode, the PH value detection electrode, the hydrogen peroxide electrode, the PH value detection signal output contact, the hydrogen peroxide signal output contact and the connecting line between the oxygen signal output contact are all covered with the insulating protective film.
The Glucose Oxidase (GOD) electrode sensor chip provided by the invention has high detection precision and high speed.
The beneficial effects of the invention are as follows: the blood sugar detector is provided with a detection report printing device which can print out a blood sugar detection report, and the detection result is clear at a glance; the blood sugar detector is provided with a data memory, and medical staff can call historical data, thereby facilitating diagnosis and treatment.
Drawings
Fig. 1 is a schematic structural diagram of an embodiment of the present invention.
Fig. 2 is a schematic structural view of the biosensor electrode of fig. 1.
Reference numerals:
1. oxygen electrode
2. PH value detection electrode
3. Hydrogen peroxide electrode
4. PH value detection signal output contact
5. Hydrogen peroxide signal output contact
6. Oxygen signal output contact
7. Chip base plate
Detailed Description
The technical scheme of the invention is further described below by the specific embodiments with reference to the accompanying drawings. It is to be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention. It should be further noted that, for convenience of description, only some, but not all of the matters related to the present invention are shown in the accompanying drawings.
Referring to fig. 1 and fig. 2, the blood glucose detecting structure comprises a blood sample obtaining device, a blood glucose detecting device, a data storage, a reminding device and a detecting report printing device, wherein the blood sample obtaining device, the blood glucose detecting device and the reminding device are sequentially connected, and the blood glucose detecting device, the data storage and the detecting report printing device are sequentially connected. The blood sugar detection device comprises a biosensor and a main control unit, wherein the biosensor is connected with the main control unit.
The blood sugar detector is provided with a reminding device, and if the blood sugar is detected to exceed the standard, the reminding device is started to remind people to pay attention to diet control. The blood sugar detector is provided with a detection report printing device which can print out a blood sugar detection report, and the detection result is clear at a glance. The blood sugar detector is provided with a data memory, and medical staff can call the historical data in the data memory, thereby facilitating diagnosis and treatment. The device is integrated with functions, convenient to use and high in practicality.
The biosensor comprises a chip base plate 7, a ceramic substrate, an oxygen electrode 1, a PH value detection electrode 2, a hydrogen peroxide electrode 3, a PH value detection signal output contact 4, a hydrogen peroxide signal output contact 5, an oxygen signal output contact 6 and a connecting circuit, wherein the oxygen electrode 1, the PH value detection electrode 2, the hydrogen peroxide electrode 3, the PH value detection signal output contact 4, the hydrogen peroxide signal output contact 5 and the oxygen signal output contact 6 are processed on the ceramic substrate by using an etching method. Then, glucose oxidase with biological activity with a protective permeable membrane is covered on the upper parts of the oxygen electrode 1, the PH value detection electrode 2 and the hydrogen peroxide electrode 3, the PH value detection signal output contact 4, the hydrogen peroxide signal output contact 5 and the oxygen signal output contact 6 are metal material contacts, and the obtained electric signals are transmitted to an analysis circuit of the instrument through metal parts contacted with the contacts. The surfaces of the connecting wires among the oxygen electrode 1, the PH value detection electrode 2, the hydrogen peroxide electrode 3, the PH value detection signal output contact 4, the hydrogen peroxide signal output contact 5 and the oxygen signal output contact 6 are covered with insulating protective films so as to prevent electric signals from losing or attenuating.
In operation, the blood sample to be tested or the diluted sample is dropped on the circle formed by the oxygen electrode 1, the PH value detection electrode 2 and the hydrogen peroxide electrode 3, and the glucose (C) 6 H 12 O 6 ) The macromolecule permeates through the permeable membrane and reacts with Glucose Oxidase (GOD) in the membrane, and the macromolecule is oxidized by the Glucose Oxidase (GOD) to generate gluconic acid (C) 6 H 12 O 7 ) And hydrogen peroxide (H) 2 O 2 ) Two components, oxygen electrode 1 detects oxygen (O) 2 ) The pH value detection electrode 2 detects the acidity variation value in the sample liquid, and the hydrogen peroxide electrode 3 detects hydrogen peroxide (H 2 O 2 ) And transmitting the corresponding measured value to an analysis circuit in the instrument by detecting the electric signal, and obtaining the content value of glucose in the detected sample after calculation.
The foregoing is only illustrative of the present invention and is not to be construed as limiting thereof, but rather as various modifications, equivalent arrangements, improvements, etc., within the spirit and principles of the present invention.
Claims (5)
1. A blood glucose meter, characterized in that: the blood glucose test device comprises a blood sample acquisition device, a blood glucose test device, a data storage, a reminding device and a test report printing device, wherein the blood sample acquisition device, the blood glucose test device and the reminding device are sequentially connected, the blood glucose test device, the data storage and the test report printing device are sequentially connected, and the blood glucose test device comprises a biosensor and a test report printing device
The biosensor comprises a chip base plate, an oxygen electrode, a pH value detection electrode, a hydrogen peroxide electrode, a pH value detection signal output contact, a hydrogen peroxide signal output contact and an oxygen signal output contact which are arranged on the chip base plate, and a plurality of connecting lines, wherein the oxygen electrode, the pH value detection electrode and the hydrogen peroxide electrode are respectively and electrically connected with the pH value detection signal output contact, the hydrogen peroxide signal output contact and the oxygen signal output contact through the connecting lines;
the oxygen electrode is kept away from the one end of oxygen signal output contact is circular, the hydrogen peroxide electrode is kept away from the one end of hydrogen peroxide signal output contact is the major arc arch, the oxygen electrode is kept away from the one end of oxygen signal output contact with the hydrogen peroxide electrode is kept away from there is the clearance between the one end of hydrogen peroxide signal output contact, the oxygen electrode is kept away from the one end of oxygen signal output contact, the hydrogen peroxide electrode is kept away from the one end of hydrogen peroxide signal output contact, the pH value detection electrode is kept away from the one end of pH value detection signal output contact sets gradually from inside to outside, the pH value detection electrode is kept away from the inboard of one end of pH value detection signal output contact with the hydrogen peroxide electrode is kept away from the outside of one end of hydrogen peroxide signal output contact, the pH value detection electrode is kept away from the one end of pH value detection signal output contact is the major arc arch.
2. The glucose meter of claim 1, wherein the chip substrate is a ceramic substrate, and the oxygen electrode, the pH detecting electrode, the hydrogen peroxide electrode, the pH detecting signal output contact, the hydrogen peroxide signal output contact, the oxygen signal output contact, and the connection line are formed by etching.
3. The blood glucose meter of claim 1, wherein the oxygen electrode, the pH value detecting electrode, and the hydrogen peroxide electrode are covered with a biologically active glucose oxidase having a protective permeable membrane.
4. The glucose meter of claim 1, wherein the pH sensing signal output contact, the hydrogen peroxide signal output contact, and the oxygen signal output contact are metallic contacts.
5. The blood glucose meter of claim 1, wherein the oxygen electrode, the pH sensing electrode, the hydrogen peroxide electrode, and the connection lines between the pH sensing signal output contact, the hydrogen peroxide signal output contact, and the oxygen signal output contact are all covered with an insulating protective film.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711106009.0A CN109781821B (en) | 2017-11-10 | 2017-11-10 | Blood sugar detector |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711106009.0A CN109781821B (en) | 2017-11-10 | 2017-11-10 | Blood sugar detector |
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| Publication Number | Publication Date |
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| CN109781821A CN109781821A (en) | 2019-05-21 |
| CN109781821B true CN109781821B (en) | 2023-10-24 |
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|---|---|---|---|---|
| US4420564A (en) * | 1980-11-21 | 1983-12-13 | Fuji Electric Company, Ltd. | Blood sugar analyzer having fixed enzyme membrane sensor |
| CN1573324A (en) * | 2003-06-09 | 2005-02-02 | 爱-森斯株式会社 | Electrochemical biosensor |
| CN101561411A (en) * | 2009-05-05 | 2009-10-21 | 尹良红 | Biosensor |
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| CN202204797U (en) * | 2011-08-23 | 2012-04-25 | 广州万孚生物技术有限公司 | Blood sugar detection instrument |
| CN103190915A (en) * | 2013-04-03 | 2013-07-10 | 无锡市崇安区科技创业服务中心 | Blood glucose detector |
| CN203662765U (en) * | 2012-12-05 | 2014-06-25 | 庞德兴 | Passive minimally-invasive subcutaneous biochemical parameter detection chip |
| CN103913489A (en) * | 2013-01-09 | 2014-07-09 | 北京怡成生物电子技术有限公司 | Micro biochip for real-time detection of substances in body fluids |
| CN104470431A (en) * | 2012-05-25 | 2015-03-25 | 美敦力迷你迈德公司 | Foldover sensors and methods for making and using them |
| CN204618248U (en) * | 2015-04-01 | 2015-09-09 | 薛关炜 | A kind of wireless, real time blood sugar monitor |
| CN104918925A (en) * | 2012-12-21 | 2015-09-16 | 美艾利尔瑞士公司 | Test device for electrochemical analysis |
-
2017
- 2017-11-10 CN CN201711106009.0A patent/CN109781821B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4420564A (en) * | 1980-11-21 | 1983-12-13 | Fuji Electric Company, Ltd. | Blood sugar analyzer having fixed enzyme membrane sensor |
| CN1573324A (en) * | 2003-06-09 | 2005-02-02 | 爱-森斯株式会社 | Electrochemical biosensor |
| CN101561411A (en) * | 2009-05-05 | 2009-10-21 | 尹良红 | Biosensor |
| CN102217939A (en) * | 2011-05-26 | 2011-10-19 | 上海交通大学 | Micro tip array electrode used for minimally invasive dynamic glucose monitoring |
| CN202204797U (en) * | 2011-08-23 | 2012-04-25 | 广州万孚生物技术有限公司 | Blood sugar detection instrument |
| CN104470431A (en) * | 2012-05-25 | 2015-03-25 | 美敦力迷你迈德公司 | Foldover sensors and methods for making and using them |
| CN203662765U (en) * | 2012-12-05 | 2014-06-25 | 庞德兴 | Passive minimally-invasive subcutaneous biochemical parameter detection chip |
| CN104918925A (en) * | 2012-12-21 | 2015-09-16 | 美艾利尔瑞士公司 | Test device for electrochemical analysis |
| CN103913489A (en) * | 2013-01-09 | 2014-07-09 | 北京怡成生物电子技术有限公司 | Micro biochip for real-time detection of substances in body fluids |
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| CN204618248U (en) * | 2015-04-01 | 2015-09-09 | 薛关炜 | A kind of wireless, real time blood sugar monitor |
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