CN109781821A - A kind of blood-sugar detecting instrument - Google Patents
A kind of blood-sugar detecting instrument Download PDFInfo
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- CN109781821A CN109781821A CN201711106009.0A CN201711106009A CN109781821A CN 109781821 A CN109781821 A CN 109781821A CN 201711106009 A CN201711106009 A CN 201711106009A CN 109781821 A CN109781821 A CN 109781821A
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- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 54
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000008280 blood Substances 0.000 claims abstract description 33
- 210000004369 blood Anatomy 0.000 claims abstract description 33
- 239000001301 oxygen Substances 0.000 claims abstract description 33
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 33
- 238000001514 detection method Methods 0.000 claims abstract description 32
- 239000000758 substrate Substances 0.000 claims abstract description 12
- 238000013500 data storage Methods 0.000 claims abstract description 10
- 108010015776 Glucose oxidase Proteins 0.000 claims description 9
- 239000004366 Glucose oxidase Substances 0.000 claims description 9
- 229940116332 glucose oxidase Drugs 0.000 claims description 9
- 235000019420 glucose oxidase Nutrition 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
- 239000008103 glucose Substances 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 229910010293 ceramic material Inorganic materials 0.000 claims description 3
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 238000007689 inspection Methods 0.000 claims description 2
- 238000005259 measurement Methods 0.000 abstract 1
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- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
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- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The present invention provides a kind of blood-sugar detecting instruments, including blood sample acquisition device, blood sugar detection apparatus, data storage, alarm set and examining report printing equipment, wherein blood sample acquisition device, blood sugar detection apparatus and alarm set are linked in sequence, blood sugar detection apparatus, data storage and examining report printing equipment are linked in sequence, the blood sugar detection apparatus includes biosensor and main control unit, biosensor is connected with main control unit, the biosensor includes die substrate, and the oxygen electrode on the die substrate is set, pH value detecting electrode, hydrogen peroxide electrode, pH value detects signal output contact, hydrogen peroxide signal output contact and oxygen signal output contact, and a plurality of connection line.The detector measurement angle can significantly improve.
Description
Technical field
The present invention relates to medical treatment detection device technical fields.
Background technique
As time goes by, the trend generalized with rejuvenation is also presented in the disease incidence of diabetes.Diabetes are a kind of slow
Property disease, treatment ground the period it is longer, need often to monitor intracorporal blood sugar concentration, insulin injection to adjust blood sugar concentration.And
Existing blood glucose meter is big multi-functional more single.
Biosensor (biosensor) be using biomolecule as recognition component, by specific recognition target and by its
The signals such as light, electricity, quality are converted into realize the sensor of various biological or chemical substance detections.Biosensor is mainly by giving birth to
Object molecular recognition elements and signal adapter two parts composition.Biomolecule recognition component be with molecule distinguishability, and
The bioactive substance of direct and test substance contact.According to the difference of biological identification element, biosensor can be divided into enzyme biography
Sensor, immunosensor, nucleic acid sensor, microbiological sensor, cell sensor and biomimetic sensor etc.；And signal adapter
Mainly there are electrochemistry, optical detection elements, thermistor, field effect transistor, piezoelectric quartz crystal and surface plasma resonance
Device etc..According to the difference of energy converter, it is raw that biosensor is divided into optical biosensor, electrochemica biological sensor and quality
Object sensor, heat-measuring type biosensor and survey sound type biosensor etc..Whether biosensor not only can detect analyte
In the presence of and can to its contents level carry out quantitative analysis.
Biosensor detects the analyzer of the subject matter by biomolecule and the reciprocation of subject matter molecule
Part.Compared to culture (culturing) or polymerase chain reaction (polymerasechainreaction；PCR), bio-sensing
Device can detect the presence of subject matter molecule within a relatively short period.Certain biosensors use immunochromatography
(chromatographicimmunoassay) technology.It is continued to use however, this biosensor based on immunochromatography has
(adoption) problem.For example, most of biosensor detecting patients based on immunochromatography are in infection/disease one
Antibody (antibody) caused by after later period.
Biosensor is quick with its, it is sensitive, efficient, portable and be easy to automate etc. unique advantages clinical examination,
The fields such as food safety, environmental monitoring, national defence have very big application potential.For many years, academia and industry exist always
Making great efforts exploitation has highly sensitive, highly selective biosensor, and the highly sensitive inspection of some biosensors has been developed at present
It surveys the method for protein, nucleic acid, cell or small molecule and is used for stigmata analyte detection, environmental poisonous substance, food pollution, biological warfare
The at-once monitor etc. of agent, such as medically, biosensor can be used for monitoring the blood glucose level of diabetic, detection cause of disease
Body, diagnosis and monitoring cancer；In environmental monitoring field, biosensor can be used for harmful bacteria in sky gas and water or food, again
Metal and agrochemical detection；In military anti-terrorism field, the detectable chemistry of biosensor and bio-toxicity molecule are to avoid latent
Contact or infection.No matter this kind of biosensor shows superelevation in undoped matrix or under complex background
Sensitivity and reliable selectivity.However, current biological sensor develops still by certain limitation, especially towards existing
The quick context of detection in field.
To sum up, the biosensor Detection accuracy of the prior art is lower.
Summary of the invention
The present invention provides a kind of blood-sugar detecting instrument, including blood sample acquisition device, blood sugar detection apparatus, data storage,
Alarm set and examining report printing equipment, wherein blood sample acquisition device, blood sugar detection apparatus and alarm set are linked in sequence, blood
Sugar detection device, data storage and examining report printing equipment are linked in sequence, and the blood sugar detection apparatus includes bio-sensing
Device and main control unit, biosensor are connected with main control unit, and the biosensor includes die substrate, and are arranged in institute
State oxygen electrode, pH value detecting electrode, hydrogen peroxide electrode, pH value detection the signal output contact, hydrogen peroxide on die substrate
Signal output contact and oxygen signal output contact and a plurality of connection line, wherein the oxygen electrode, PH value detecting electrode,
Hydrogen peroxide electrode detects signal output contact by the connection line with the pH value respectively, the output of hydrogen peroxide signal is touched
Point, the electrical connection of oxygen signal output contact.
Preferably, the die substrate is the substrate of ceramic material, processes to form the oxygen electrode, pH value by etching method
Detecting electrode, hydrogen peroxide electrode, pH value detection signal output contact, hydrogen peroxide signal output contact, oxygen signal output touching
Point and connection line.
Preferably, the oxygen electrode, pH value detecting electrode, hydrogen peroxide electrode upper covering having with protection permeable membrane
The glucose oxidase of bioactivity.
Preferably, the pH value detection signal output contact, hydrogen peroxide signal output contact, oxygen signal output contact are
Metal material contact.
Preferably, the oxygen electrode, pH value detecting electrode, hydrogen peroxide electrode and pH value detect signal output contact, mistake
Connection line among oxidation hydrogen signal output contact, oxygen signal output contact covers insulating protective film.
Glucose oxidase (GOD) electrode sensor chip detection accuracy provided by the invention is high, and speed is fast.
Beneficial effects of the present invention are as follows: can report blood sugar test equipped with examining report printing equipment on blood-sugar detecting instrument
It prints, testing result is very clear；Data storage is housed, medical staff calls historical data, side on blood-sugar detecting instrument
Just diagnoses and treatment.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of one embodiment of the invention.
Fig. 2 is the structural schematic diagram of Fig. 1 biological sensor electrode.
Appended drawing reference:
1, oxygen electrode
2, pH value detecting electrode
3, hydrogen peroxide electrode
4, pH value detects signal output contact
5, hydrogen peroxide signal output contact
6, oxygen signal output contact
7, die substrate
Specific embodiment
To further illustrate the technical scheme of the present invention below with reference to the accompanying drawings and specific embodiments.It is understood that
It is that described herein the specific embodiments are only for explaining the present invention, rather than limitation of the invention.Further need exist for explanation
It is, for ease of description, only some but not all contents related to the present invention are shown in the drawings.
It is combined with Figure 1 and Figure 2, a kind of blood sugar test structure, including blood sample acquisition device, blood sugar detection apparatus, data are deposited
Reservoir, alarm set and examining report printing equipment, wherein blood sample acquisition device, blood sugar detection apparatus and alarm set sequence connect
It connects, blood sugar detection apparatus, data storage and examining report printing equipment are linked in sequence.The blood sugar detection apparatus includes biology
Sensor and main control unit, biosensor are connected with main control unit.
Alarm set is housed, if detecting that blood glucose is exceeded, alarm set just be will start, and remind people on blood-sugar detecting instrument
Pay attention to keeping on a diet.Blood sugar test can be reported and be printed equipped with examining report printing equipment on blood-sugar detecting instrument, detection knot
Fruit is very clear.Data storage is housed, medical staff can call the historical data in data storage, side on blood-sugar detecting instrument
Just diagnoses and treatment.The apparatus function is integrated, easy to use, practical.
Wherein, biosensor includes die substrate 7, is the substrate of ceramic material, is processed on it using etching method
Oxygen electrode 1, pH value detecting electrode 2, hydrogen peroxide electrode 3, pH value detection signal output contact 4, the output touching of hydrogen peroxide signal
Point 5,6 component of oxygen signal output contact and connection line.Then in oxygen electrode 1, pH value detecting electrode 2, hydrogen peroxide electrode 3
The glucose oxidase that has bioactivity of the top covering with protection permeable membrane, pH value detect signal output contact 4, peroxidating
Hydrogen signal output contact 5, oxygen signal output contact 6 are that metal material contact will be obtained by the metal parts being in contact with it
Electric signal be transferred in the analysis circuit of instrument.Oxygen electrode 1, pH value detecting electrode 2, hydrogen peroxide electrode 3 and pH value detect
Signal output contact 4, hydrogen peroxide signal output contact 5, the line surface among oxygen signal output contact 6 cover insulation
Protective film, to prevent electric signal from losing or decaying.
When work, by inspected blood sample or sample droplets after diluting in oxygen electrode 1, pH value detecting electrode 2, peroxidating
Circled composed by hydrogen electrode 3, contained glucose (C in examined samples6H12O6) macromolecular is through permeable membrane, with inside
Glucose oxidase (GOD) react, by glucose oxidase (GOD) oxidation after generate gluconic acid (C6H12O7) and
Hydrogen peroxide (H2O2) two kinds of compositions, oxygen electrode 1 detects oxygen (O in sample2) consumption value, pH value detecting electrode 2 detect sample liquid
Interior acidity changing value, hydrogen peroxide electrode 3 detect hydrogen peroxide (H2O2) yield, and by detection electric signal will be corresponding
Measured value be transferred in the analysis circuit of instrument internal, through calculating after, can be obtained containing for the glucose in examined samples
Numerical quantity.
The foregoing is merely a prefered embodiment of the invention, is not intended to limit the invention, all in the spirit and principles in the present invention
Within, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.
Claims (5)
1. a kind of blood-sugar detecting instrument, it is characterised in that: including blood sample acquisition device, blood sugar detection apparatus, data storage, prompting
Device and examining report printing equipment, wherein blood sample acquisition device, blood sugar detection apparatus and alarm set are linked in sequence, blood glucose inspection
Survey device, data storage and examining report printing equipment are linked in sequence, the blood sugar detection apparatus include biosensor and
Main control unit, biosensor are connected with main control unit, and the biosensor includes die substrate, and are arranged in the core
Oxygen electrode, pH value detecting electrode, hydrogen peroxide electrode, pH value on piece bottom plate detect signal output contact, hydrogen peroxide signal
Output contact and oxygen signal output contact and a plurality of connection line, wherein the oxygen electrode, pH value detecting electrode, peroxidating
Hydrogen electrode detects signal output contact, hydrogen peroxide signal output contact, oxygen with the pH value respectively by the connection line
The electrical connection of signal output contact.
2. sensor chip as described in claim 1, which is characterized in that the die substrate is the substrate of ceramic material, is led to
Overetch method processes to form the oxygen electrode, pH value detecting electrode, hydrogen peroxide electrode, pH value detection signal output contact, mistake
Aoxidize hydrogen signal output contact, oxygen signal output contact and connection line.
3. sensor chip as described in claim 1, which is characterized in that the oxygen electrode, pH value detecting electrode, hydrogen peroxide
The glucose oxidase that has bioactivity of the electrode upper covering with protection permeable membrane.
4. sensor chip as described in claim 1, which is characterized in that the pH value detects signal output contact, peroxidating
Hydrogen signal output contact, oxygen signal output contact are metal material contact.
5. sensor chip as described in claim 1, which is characterized in that the oxygen electrode, pH value detecting electrode, hydrogen peroxide
Electrode and pH value detection signal output contact, hydrogen peroxide signal output contact, the connection line among oxygen signal output contact
Cover insulating protective film.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711106009.0A CN109781821B (en) | 2017-11-10 | 2017-11-10 | Blood sugar detector |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711106009.0A CN109781821B (en) | 2017-11-10 | 2017-11-10 | Blood sugar detector |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109781821A true CN109781821A (en) | 2019-05-21 |
| CN109781821B CN109781821B (en) | 2023-10-24 |
Family
ID=66485208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711106009.0A Active CN109781821B (en) | 2017-11-10 | 2017-11-10 | Blood sugar detector |
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| Country | Link |
|---|---|
| CN (1) | CN109781821B (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4420564A (en) * | 1980-11-21 | 1983-12-13 | Fuji Electric Company, Ltd. | Blood sugar analyzer having fixed enzyme membrane sensor |
| CN101561411A (en) * | 2009-05-05 | 2009-10-21 | 尹良红 | Biosensor |
| CN102217939A (en) * | 2011-05-26 | 2011-10-19 | 上海交通大学 | Micro tip array electrode used for minimally invasive dynamic glucose monitoring |
| CN202204797U (en) * | 2011-08-23 | 2012-04-25 | 广州万孚生物技术有限公司 | Blood sugar detection instrument |
| CN103190915A (en) * | 2013-04-03 | 2013-07-10 | 无锡市崇安区科技创业服务中心 | Blood glucose detector |
| CN203662765U (en) * | 2012-12-05 | 2014-06-25 | 庞德兴 | Passive minimally-invasive subcutaneous biochemical parameter detection chip |
| CN204618248U (en) * | 2015-04-01 | 2015-09-09 | 薛关炜 | A kind of wireless, real time blood sugar monitor |
| CN104918925A (en) * | 2012-12-21 | 2015-09-16 | 美艾利尔瑞士公司 | Test device for electrochemical analysis |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100554649B1 (en) * | 2003-06-09 | 2006-02-24 | 주식회사 아이센스 | Electrochemical biosensor |
| US9493807B2 (en) * | 2012-05-25 | 2016-11-15 | Medtronic Minimed, Inc. | Foldover sensors and methods for making and using them |
| CN103913489B (en) * | 2013-01-09 | 2015-06-10 | 北京怡成生物电子技术股份有限公司 | Micro biochip for real-time detection of substances in body fluids |
-
2017
- 2017-11-10 CN CN201711106009.0A patent/CN109781821B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4420564A (en) * | 1980-11-21 | 1983-12-13 | Fuji Electric Company, Ltd. | Blood sugar analyzer having fixed enzyme membrane sensor |
| CN101561411A (en) * | 2009-05-05 | 2009-10-21 | 尹良红 | Biosensor |
| CN102217939A (en) * | 2011-05-26 | 2011-10-19 | 上海交通大学 | Micro tip array electrode used for minimally invasive dynamic glucose monitoring |
| CN202204797U (en) * | 2011-08-23 | 2012-04-25 | 广州万孚生物技术有限公司 | Blood sugar detection instrument |
| CN203662765U (en) * | 2012-12-05 | 2014-06-25 | 庞德兴 | Passive minimally-invasive subcutaneous biochemical parameter detection chip |
| CN104918925A (en) * | 2012-12-21 | 2015-09-16 | 美艾利尔瑞士公司 | Test device for electrochemical analysis |
| CN103190915A (en) * | 2013-04-03 | 2013-07-10 | 无锡市崇安区科技创业服务中心 | Blood glucose detector |
| CN204618248U (en) * | 2015-04-01 | 2015-09-09 | 薛关炜 | A kind of wireless, real time blood sugar monitor |
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