CN109781804A - A kind of blood sugar test module - Google Patents
A kind of blood sugar test module Download PDFInfo
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- CN109781804A CN109781804A CN201711105214.5A CN201711105214A CN109781804A CN 109781804 A CN109781804 A CN 109781804A CN 201711105214 A CN201711105214 A CN 201711105214A CN 109781804 A CN109781804 A CN 109781804A
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- electrode
- information output
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- oxygen
- hydrogen peroxide
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Abstract
The present invention provides a kind of blood sugar test modules, including sample acquiring device, sample test sensor device, information processing unit, retest feedback device, show output device, the sample acquiring device, sample test sensor device, information processing unit, retest feedback device, display output device is successively linked in sequence, the retest feedback device is connect with sample acquiring device, wherein, the sample test sensor device includes die substrate, and the oxygen electrode on the die substrate is set, pH value tests electrode, hydrogen peroxide electrode, pH value tests information output contact, hydrogen peroxide information output contact and oxygen information output contact, and a plurality of connection line.The blood sugar test module monitors are quick and precisely.
Description
Technical field
The present invention relates to blood sugar test equipment.
Background technique
The test method of blood glucose can be divided into invasive, minimally invasive and noninvasive method at present.The test method of invasive and minimally invasive blood glucose is all
It is invasive with different degrees of tissue, and continuously measuring blood glucose in a short time at present becomes the hand of a common treatment diabetes
Section, therefore pain is brought to patient, there is the possibility of infection, patient has fear, and testing expense is more expensive, therefore
Using limited.
Biosensor (biosensor) be using biomolecule as recognition component, by specific recognition target and by its
The information such as light, electricity, quality are converted into realize the sensor of various biological or chemical substance testings.Biosensor is mainly by giving birth to
Object molecular recognition elements and transcriber two parts composition.Biomolecule recognition component be with molecule distinguishability, and
The bioactive substance of direct and test substance contact.According to the difference of biological identification element, biosensor can be divided into enzyme biography
Sensor, immunosensor, nucleic acid sensor, microbiological sensor, cell sensor and biomimetic sensor etc.；And transcriber
Mainly there are electrochemistry, optic test element, thermistor, field effect transistor, piezoelectric quartz crystal and surface plasma resonance
Device etc..According to the difference of energy converter, it is raw that biosensor is divided into optical biosensor, electrochemica biological sensor and quality
Object sensor, heat-measuring type biosensor and survey sound type biosensor etc..Biosensor not only can test analyte whether
In the presence of and can to its contents level carry out quantitative analysis.
Biosensor detects the analyzer of the subject matter by biomolecule and the reciprocation of subject matter molecule
Part.Compared to culture (culturing) or polymerase chain reaction (polymerasechainreaction；PCR), bio-sensing
Device can detect the presence of subject matter molecule within a relatively short period.Certain biosensors use immunochromatography
(chromatographicimmunoassay) technology.It is continued to use however, this biosensor based on immunochromatography has
(adoption) problem.For example, most of biosensor detecting patients based on immunochromatography are in infection/disease one
Antibody (antibody) caused by after later period.
Biosensor is quick with its, it is sensitive, efficient, portable and be easy to automate etc. unique advantages clinical examination,
The fields such as food safety, environmental monitoring, national defence have very big application potential.For many years, academia and industry exist always
Making great efforts exploitation has highly sensitive, highly selective biosensor, and the highly sensitive survey of some biosensors has been developed at present
It tries the method for protein, nucleic acid, cell or small molecule and is used for disease marker test, environmental poisonous substance, food pollution, biological warfare
The at-once monitor etc. of agent, such as medically, biosensor can be used for monitoring the blood glucose level of diabetic, test cause of disease
Body, diagnosis and monitoring cancer；In environmental monitoring field, biosensor can be used for harmful bacteria in sky gas and water or food, again
Metal and agrochemical test；In military anti-terrorism field, biosensor can test chemistry and bio-toxicity molecule to avoid latent
Contact or infection.No matter this kind of biosensor shows superelevation in undoped matrix or under complex background
Sensitivity and reliable selectivity.However, current biological sensor develops still by certain limitation, especially towards existing
Field is quickly in terms of test.
To sum up, the biosensor test accuracy rate of the prior art is lower.
Summary of the invention
The present invention provides a kind of blood sugar test modules, including sample acquiring device, sample test sensor device, information
Processing unit, retest feedback device, display output device, the sample acquiring device, sample test sensor device, letter
Breath processing unit, retest feedback device, display output device are successively linked in sequence, the retest feedback device and sample
Product acquisition device connection, wherein the sample test sensor device includes die substrate, and is arranged in the die substrate
On oxygen electrode, pH value test electrode, hydrogen peroxide electrode, pH value test information output contact, hydrogen peroxide information output touching
Point and oxygen information output contact and a plurality of connection line, wherein the oxygen electrode, pH value test electrode, hydrogen peroxide electrode
It is defeated that information output contact, hydrogen peroxide information output contact, oxygen information are tested with the pH value respectively by the connection line
Contact is electrically connected out.
Preferably, the die substrate is the substrate of ceramic material, processes to form the oxygen electrode, pH value by etching method
Test electrode, hydrogen peroxide electrode, pH value test information output contact, hydrogen peroxide information output contact, the output touching of oxygen information
Point and connection line.
Preferably, the oxygen electrode, pH value test electrode, hydrogen peroxide electrode upper covering having with protection permeable membrane
The glucose oxidase of bioactivity.
Preferably, the pH value test information output contact, hydrogen peroxide information output contact, oxygen information output contact are
Metal material contact.
Preferably, the oxygen electrode, pH value test electrode, hydrogen peroxide electrode and pH value test information output contact, mistake
Connection line among hydrogen oxide information output contact, oxygen information output contact covers insulating protective film.
The blood sugar test module monitors are quick and precisely.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of one embodiment of the invention.
Appended drawing reference:
1, oxygen electrode
2, pH value tests electrode
3, hydrogen peroxide electrode
4, pH value tests information output contact
5, hydrogen peroxide information output contact
6, oxygen information output contact
7, die substrate
Specific embodiment
To further illustrate the technical scheme of the present invention below with reference to the accompanying drawings and specific embodiments.It is understood that
It is that described herein the specific embodiments are only for explaining the present invention, rather than limitation of the invention.Further need exist for explanation
It is, for ease of description, only some but not all contents related to the present invention are shown in the drawings.
Be the blood sugar test module of the present embodiment in conjunction with Fig. 1, including sample acquiring device, sample test sensor device,
Information processing unit, retest feedback device, display output device, the sample acquiring device, sample test sensor dress
It sets, information processing unit, retest feedback device, show that output device is successively linked in sequence, the retest feedback dress
It sets and is connect with sample acquiring device.
Sample acquiring device is used to obtain the sample of related data, specifically: sample acquiring device is used to monitor for test
Instrument operator carries out the setting that sample obtains condition.It is arranged purpose be for according to preset impulse condition in sampling sites shape
At the noninvasive impulse for changing blood glucose response, which can be the sampling sites in existing invasive blood sugar test.Sample obtains
It takes device and can complete to sampling sites to seal, the impulses movement such as pressure regulation or negative pressure, various test agents, original can also be completed
The supply of material, such as the supply of oxygen, glucose oxidase.
Sample test sensor device for will acquire sample changeover be power information, information processing unit by the power information into
Row series of processes, in order to improve measuring accuracy, by the information handled be sent to retest feedback device determine the need for into
Row retest, if it is desired, information is fed back to sample test acquisition device, if it is not needed, directly carrying out display output.
The course of work of this example: before starting test, allowing people to be measured to sit quietly, and keeps breathing tranquil and keeps referring to that face is cleaned；It will
Right hand middle finger, which is put on sample acquiring device, carries out data acquisition；The data transmission of acquisition gives sample test sensor device, will
Data are converted to power information；The information is sent to retest feedback device after information processing unit is handled and determines the need for
Carry out retest, if it is desired, information is fed back to sample test acquisition device, if it is not needed, directly carrying out display output.
Working principle are as follows: sample acquiring device obtains index of correlation, is then delivered to sample test sensor and is tested
Human Physiology amount information, the information pass through information processing unit (i.e. information conditioning circuit, analogue filter circuit, amplifying circuit, A/
D converter, telecommunication circuit) processing after, processing is modified by retest feedback device further according to actual conditions, finally by
Show that output device shows final result.
Sample test sensor device includes die substrate 7, is the substrate of ceramic material, is processed on it using etching method
Oxygen electrode 1, pH value test electrode 2, hydrogen peroxide electrode 3, pH value test information output contact 4, the output of hydrogen peroxide information out
Contact 5,6 component of oxygen information output contact and connection line.Then in oxygen electrode 1, pH value test electrode 2, hydrogen peroxide electricity
The glucose oxidase that has bioactivity of 3 top of the pole covering with protection permeable membrane, pH value test information output contact 4, mistake
Hydrogen oxide information output contact 5, oxygen information output contact 6 are metal material contact, by the metal parts being in contact with it, by institute
The power information of acquisition is transferred in the analysis circuit of instrument.Oxygen electrode 1, pH value test electrode 2, hydrogen peroxide electrode 3 and pH value
Test information output contact 4, hydrogen peroxide information output contact 5, the line surface among oxygen information output contact 6 cover absolutely
Edge protective film, to prevent power information from losing or decaying.
When work, inspected blood sample or the sample drop after diluting are tested into electrode 2, peroxidating in oxygen electrode 1, pH value
Circled composed by hydrogen electrode 3, by glucose (C contained in sample product6H12O6) macromolecular is through permeable membrane, with inside
Glucose oxidase (GOD) reacts, and is generated gluconic acid (C after glucose oxidase (GOD) oxidation6H12O7) and mistake
Hydrogen oxide (H2O2) two kinds of compositions, oxygen (O in 1 test sample of oxygen electrode2) consumption value, pH value test 2 test sample liquid of electrode in
Acidity changing value, hydrogen peroxide electrode 3 test hydrogen peroxide (H2O2) yield, and by test power information will be corresponding
Measured value is transferred in the analysis circuit of instrument internal, after calculating, can be obtained the content by the glucose in sample product
Numerical value.
The foregoing is merely a prefered embodiment of the invention, is not intended to limit the invention, all in the spirit and principles in the present invention
Within, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.
Claims (5)
1. a kind of blood sugar test module, it is characterised in that: at sample acquiring device, sample test sensor device, information
Manage device, retest feedback device, display output device, the sample acquiring device, sample test sensor device, information
Processing unit, retest feedback device, display output device are successively linked in sequence, the retest feedback device and sample
Acquisition device connection, wherein the sample test sensor device includes die substrate, and is arranged on the die substrate
Oxygen electrode, pH value test electrode, hydrogen peroxide electrode, pH value test information output contact, hydrogen peroxide information output contact
With oxygen information output contact and a plurality of connection line, wherein the oxygen electrode, pH value test electrode, hydrogen peroxide electrode are logical
The connection line is crossed to export with pH value test information output contact, hydrogen peroxide information output contact, oxygen information respectively
Contact electrical connection.
2. sensor chip as described in claim 1, which is characterized in that the die substrate is the substrate of ceramic material, is led to
Overetch method processes to form the oxygen electrode, pH value test electrode, hydrogen peroxide electrode, pH value test information output contact, mistake
Hydrogen oxide information output contact, oxygen information output contact and connection line.
3. sensor chip as described in claim 1, which is characterized in that the oxygen electrode, pH value test electrode, hydrogen peroxide
The glucose oxidase that has bioactivity of the electrode upper covering with protection permeable membrane.
4. sensor chip as described in claim 1, which is characterized in that the pH value tests information output contact, peroxidating
Hydrogen information output contact, oxygen information output contact are metal material contact.
5. sensor chip as described in claim 1, which is characterized in that the oxygen electrode, pH value test electrode, hydrogen peroxide
Electrode and pH value test information output contact, hydrogen peroxide information output contact, the connection line among oxygen information output contact
Cover insulating protective film.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711105214.5A CN109781804A (en) | 2017-11-10 | 2017-11-10 | A kind of blood sugar test module |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711105214.5A CN109781804A (en) | 2017-11-10 | 2017-11-10 | A kind of blood sugar test module |
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| Publication Number | Publication Date |
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| CN109781804A true CN109781804A (en) | 2019-05-21 |
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| CN201711105214.5A Pending CN109781804A (en) | 2017-11-10 | 2017-11-10 | A kind of blood sugar test module |
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|---|---|---|---|---|
| US4374013A (en) * | 1980-03-05 | 1983-02-15 | Enfors Sven Olof | Oxygen stabilized enzyme electrode |
| CN101393200A (en) * | 2007-09-21 | 2009-03-25 | 五鼎生物技术股份有限公司 | Electrochemical quantitative analysis system and method |
| CN101561411A (en) * | 2009-05-05 | 2009-10-21 | 尹良红 | Biosensor |
| WO2010121414A1 (en) * | 2009-04-21 | 2010-10-28 | Zhang Fan | Non-invasive blood sugar monitor and method to monitor the blood sugar |
| CN102217939A (en) * | 2011-05-26 | 2011-10-19 | 上海交通大学 | Micro tip array electrode used for minimally invasive dynamic glucose monitoring |
| CN202204797U (en) * | 2011-08-23 | 2012-04-25 | 广州万孚生物技术有限公司 | Blood sugar detection instrument |
| CN102772213A (en) * | 2012-07-20 | 2012-11-14 | 天津市亚鼎科技有限公司 | Multifunctional blood sugar detection system |
| CN202821361U (en) * | 2012-07-20 | 2013-03-27 | 天津市亚鼎科技有限公司 | Multifunctional blood glucose detection system |
| CN203662765U (en) * | 2012-12-05 | 2014-06-25 | 庞德兴 | Passive minimally-invasive subcutaneous biochemical parameter detection chip |
| CN204613145U (en) * | 2015-05-08 | 2015-09-02 | 武汉大学 | A kind of blood sugar test paper |
| CN204618248U (en) * | 2015-04-01 | 2015-09-09 | 薛关炜 | A kind of wireless, real time blood sugar monitor |
| CN104918925A (en) * | 2012-12-21 | 2015-09-16 | 美艾利尔瑞士公司 | Test device for electrochemical analysis |
-
2017
- 2017-11-10 CN CN201711105214.5A patent/CN109781804A/en active Pending
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4374013A (en) * | 1980-03-05 | 1983-02-15 | Enfors Sven Olof | Oxygen stabilized enzyme electrode |
| CN101393200A (en) * | 2007-09-21 | 2009-03-25 | 五鼎生物技术股份有限公司 | Electrochemical quantitative analysis system and method |
| WO2010121414A1 (en) * | 2009-04-21 | 2010-10-28 | Zhang Fan | Non-invasive blood sugar monitor and method to monitor the blood sugar |
| CN101561411A (en) * | 2009-05-05 | 2009-10-21 | 尹良红 | Biosensor |
| CN102217939A (en) * | 2011-05-26 | 2011-10-19 | 上海交通大学 | Micro tip array electrode used for minimally invasive dynamic glucose monitoring |
| CN202204797U (en) * | 2011-08-23 | 2012-04-25 | 广州万孚生物技术有限公司 | Blood sugar detection instrument |
| CN102772213A (en) * | 2012-07-20 | 2012-11-14 | 天津市亚鼎科技有限公司 | Multifunctional blood sugar detection system |
| CN202821361U (en) * | 2012-07-20 | 2013-03-27 | 天津市亚鼎科技有限公司 | Multifunctional blood glucose detection system |
| CN203662765U (en) * | 2012-12-05 | 2014-06-25 | 庞德兴 | Passive minimally-invasive subcutaneous biochemical parameter detection chip |
| CN104918925A (en) * | 2012-12-21 | 2015-09-16 | 美艾利尔瑞士公司 | Test device for electrochemical analysis |
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