CN109770916A - Non-invasive blood glucose meter Raman light acquisition method, collector and blood glucose meter - Google Patents
Non-invasive blood glucose meter Raman light acquisition method, collector and blood glucose meter Download PDFInfo
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- CN109770916A CN109770916A CN201910059933.0A CN201910059933A CN109770916A CN 109770916 A CN109770916 A CN 109770916A CN 201910059933 A CN201910059933 A CN 201910059933A CN 109770916 A CN109770916 A CN 109770916A
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Abstract
The present invention provides a kind of non-invasive blood glucose meter Raman light acquisition method, collector and blood glucose meter, the non-invasive blood glucose meter Raman light collector is in finger shell-like, in the inscribed Raman light for receiving incident ray and acquire finger reflection of the incident ray through being inserted into the finger-stall of finger-stall；The non-invasive blood glucose meter Raman light collector includes multiple light collection terminals that one light source transmitting terminal of transmitting predetermined beam and the acquisition incident ray handle digital reflex into the finger-stall；The port of multiple light collection terminals and the port close-packed arrays of the light source transmitting terminal form the inner surface of the finger-stall；The light source transmitting terminal is located at the corresponding fingertip location of the finger-stall.Raman light collector in the present invention is the finger-stall shape that a port by many fiber optics forms, and can collect the scattered photon of all directions, while also shielding the interference of extraneous infrared light, enhance the intensity of Raman light, be convenient for spectrum analysis.
Description
Technical field
The present invention relates to medical treatment & health fields, more particularly to blood glucose meter technical field, specially a kind of non-invasive blood
Sugared instrument Raman light acquisition method, collector and blood glucose meter.
Background technique
With the variation of people's dietary structure and rhythm of life and the raising of aging of population degree, diabetes morbidity
Increase sharply, shown according to " 2012 world health statistics " report, the people in the whole world 1/10th suffers from diabetes, diabetes and its
Complication has become the serious public health problem that countries in the world face.There is presently no the methods of thorough treatment diabetes, face
Mainly by monitoring blood sugar concentration frequently come direction of medication usage on bed, detecting blood sugar concentration is the key that diabetes diagnosis and treatment,
It is also the effective measures of prevention diabetic complication.The blood sugar detecting method being currently widely used includes: the detection, fast of phlebotomizing
Fast Instrument for Measuring Blood Sugar detection, blood sugar test paper colorimetric detection etc., belong to invasive or minimally invasive detection.A blood glucose value is often measured, it must
It must once be taken a blood sample and consume a reagent chemicals, detection formality is many and diverse, costly, and draws blood and will cause pain, and have
The danger of infection.This not only increases pain and financial burden to patient, can not accomplish real-time monitoring.
Therefore, in order to solve existing blood glucose biochemical detection methods inconvenience caused by diabetes patient, there is an urgent need to explore more
Add the blood sugar concentration detection means of hommization.It is not required to puncture skin blood sampling using noninvasive dynamics monitoring technology, significantly improve
Diabetic frequently takes a blood sample, and bring is inconvenient and pain, also avoids the cross-infection and environmental pollution caused by blood sampling；Together
When, detection number can be increased, improve glycemic control accuracy, have become the emphasis of various countries' research in recent years.For example,
Biocontrol Technology company, Samsung Fine Chemicals company etc. utilize near-infrared spectrum technique,
Cygnus company using reverse ion electrophoretic techniques detection blood sugar concentration (the big detection technique Parallel Development of blood glucose three, Li Yanbin, in
State's medicine report, 2009.03.3), but can seldom be authenticated by U.S. FDA.Patent CN 102198004A discloses a kind of non-invasive
Near-infrared electronic blood-glucose meter, it carries out the quick and precisely detection of non-invasive blood sugar concentration using near infrared spectrum.
But the relevant technologies so far about Raman spectrum detection, it is to receive light using parabolic type mirror to increase
The scattering of son, the still only insufficient half at the omni-directional stereo angle of all directions.Raman photon scattering is all directions, single
The receiving surface in direction is lost many useful photons, and most of Raman photon is not received, this results in Raman light
The signal of spectrum is weaker, keeps spectrum analysis difficult.
Summary of the invention
In order to solve above-mentioned and other potential technical problems, the embodiment provides a kind of non-invasive
Blood glucose meter Raman light collector, the non-invasive blood glucose meter Raman light collector are in finger shell-like, in the inscribed income of finger-stall
It penetrates light and acquires the Raman light of finger reflection of the incident ray through being inserted into the finger-stall.
In one embodiment of the invention, the non-invasive blood glucose meter Raman light collector includes into the finger-stall
Emit a light source transmitting terminal of predetermined beam and acquires multiple light collection terminals that the incident ray handles digital reflex.
In one embodiment of the invention, the port of multiple light collection terminals and the port of the light source transmitting terminal are tight
Solid matter arranges the inner surface to form the finger-stall.
In one embodiment of the invention, the light source transmitting terminal is located at the corresponding fingertip location of the finger-stall.
In one embodiment of the invention, the light collection terminal be fiber optics line one end, the fiber optics line it is another
One end connects spectrometer.
In one embodiment of the invention, the light source transmitting terminal is infrared light supply transmitting terminal.
The embodiment of the present invention also provides a kind of blood glucose meter, including the non-invasive blood glucose meter Raman as described above
Light collector.
The embodiment of the present invention also provides a kind of non-invasive blood glucose meter Raman light acquisition method, the non-invasive blood glucose
Instrument Raman light acquisition method includes: in the inscribed receipts incident ray of gloved-figer Raman light collector；Acquire the incident light
Raman light of the line through the finger reflection in insertion finger-stall.
In one embodiment of the invention, the non-invasive blood glucose meter Raman light collector includes into the finger-stall
Emit a light source transmitting terminal of predetermined beam and acquires multiple light collection terminals that the incident ray handles digital reflex.
In one embodiment of the invention, the port of multiple light collection terminals and the port of the light source transmitting terminal are tight
Solid matter arranges the inner surface to form the finger-stall.
In one embodiment of the invention, the light source transmitting terminal is located at the corresponding fingertip location of the finger-stall.
As described above, non-invasive blood glucose meter Raman light acquisition method, collector and blood glucose meter of the invention are with following
The utility model has the advantages that
Raman light collector in the present invention is the finger-stall shape that a port by many fiber optics forms, this
Sample can collect the scattered photon of all directions, while also shield the interference of extraneous infrared light, enhance the intensity of Raman light, just
In progress spectrum analysis.
Detailed description of the invention
To describe the technical solutions in the embodiments of the present invention more clearly, make required in being described below to embodiment
Attached drawing is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the invention, for
For those of ordinary skill in the art, without creative efforts, it can also be obtained according to these attached drawings other
Attached drawing.
Fig. 1 is shown as the principle schematic diagram of the non-invasive blood glucose meter Raman light collector in the present invention.
Fig. 2 is shown as the concrete structure schematic diagram of the non-invasive blood glucose meter Raman light collector in the present invention.
Fig. 3 is shown as the flow diagram of non-invasive blood glucose meter Raman light acquisition method of the invention.
Component label instructions
100 non-invasive blood glucose meter Raman light collectors
110 light source transmitting terminals
120 light collection terminals
200 fingers
300 spectrometers
S110~S120 step
Specific embodiment
Illustrate embodiments of the present invention below by way of specific specific example, those skilled in the art can be by this specification
Other advantages and efficacy of the present invention can be easily understood for disclosed content.The present invention can also pass through in addition different specific realities
The mode of applying is embodied or practiced, the various details in this specification can also based on different viewpoints and application, without departing from
Various modifications or alterations are carried out under spirit of the invention.It should be noted that in the absence of conflict, following embodiment and implementation
Feature in example can be combined with each other.
It please refers to Fig.1 to Fig.3.It should be clear that this specification structure depicted in this specification institute accompanying drawings, ratio, size etc., only to
Cooperate the revealed content of specification, so that those skilled in the art understands and reads, being not intended to limit the invention can be real
The qualifications applied, therefore do not have technical essential meaning, the tune of the modification of any structure, the change of proportionate relationship or size
It is whole, in the case where not influencing the effect of present invention can be generated and the purpose that can reach, it should all still fall in disclosed skill
Art content obtains in the range of capable of covering.Meanwhile in this specification it is cited as "upper", "lower", "left", "right", " centre " and
The term of " one " etc. is merely convenient to being illustrated for narration, rather than to limit the scope of the invention, relativeness
It is altered or modified, under the content of no substantial changes in technology, when being also considered as the enforceable scope of the present invention.
The purpose of the present embodiment is that providing a kind of non-invasive blood glucose meter Raman light acquisition method, collector and blood glucose
Instrument is not received for solving most of Raman photon in prior art Raman light collector, causes Raman spectrum
Signal is weaker, to make the problem of spectrum analysis difficulty.
The original of non-invasive blood glucose meter Raman light acquisition method of the invention described in detail below, collector and blood glucose meter
Reason and embodiment make those skilled in the art not need creative work and are appreciated that non-invasive blood glucose meter of the invention is drawn
Graceful gloss set method, collector and blood glucose meter.
Embodiment 1
Fig. 1 is the schematic illustration for the non-invasive blood glucose meter Raman light collector 100 that the present embodiment is related to.Specifically,
As shown in Figure 1, present embodiments providing a kind of non-invasive blood glucose meter Raman light collector 100, the non-invasive blood glucose meter
Raman light collector 100 is in finger shell-like, in the inscribed receipts incident ray of finger-stall and acquires the incident ray through described in insertion
The Raman light that finger 200 in finger-stall reflects.
Wherein, the non-invasive blood glucose meter Raman light collector 100 when in use, gloved-figer Raman light collector
It covers on the finger 200 of user, in the inscribed receipts incident ray of finger-stall and acquires the incident ray through being inserted into the finger-stall
The Raman light that interior finger 200 reflects.
Specifically, as shown in Fig. 2, in this present embodiment, the non-invasive blood glucose meter Raman light collector 100 include to
A light source transmitting terminal 110 of transmitting predetermined beam and the acquisition incident ray are reflected through finger 200 in the finger-stall
Multiple light collection terminals 120 (light collection terminal 1201 shown in Fig. 1, light collection terminal 1202... light collection terminal 120N).
Further, in this present embodiment, the port of multiple light collection terminals 120 and the light source transmitting terminal
110 port close-packed arrays form the inner surface of the finger-stall.
That is, in this present embodiment, the non-invasive blood glucose meter Raman light collector 100 is by multiple light
The port close-packed arrays of the port of line collection terminal 120 and the light source transmitting terminal 110 are constituted in finger shell-like.
The hand of the port close-packed arrays composition of the port and light source transmitting terminal 110 of multiple light collection terminals 120
The diameter of fingerstall is matched with 200 size of finger of ordinary person, when finger 200 protrudes into the finger-stall, 200 surface of finger with
The finger-stall abutting is advisable.The length of the finger-stall is 1cm to 10cm, for example, finger tip to the length between articulations digitorum manus.
Do not limit the length of the finger-stall specifically herein, user can choose the finger of suitable length according to the principle of the present embodiment
Set.
In this present embodiment, wherein the port of the light source transmitting terminal 110 is one, it is preferable that the light source transmitting terminal
110 are located at the corresponding fingertip location of the finger-stall.
As it can be seen that the whole port by multiple light collection terminals 120 of the finger-stall surrounds and forms, multiple light
The port of collection terminal 120 constitutes the inner surface of the finger-stall, and the inner surface of entire finger-stall can acquire in finger-stall
Light.
In this way, the light that emits of the light source transmitting terminal 110 is from gloved-figer non-invasive blood glucose meter Raman light collection
Cavity emissivity at from the finger tip of device 100 to the finger-stall, the port of the light collection terminal 120 of the inner surface of entire finger-stall
The light in finger-stall can be acquired, so the Raman light collector of the present embodiment can collect the scattering light of all directions
Son enhances the intensity of Raman light, while also shielding the interference of extraneous infrared light.
In this present embodiment, the light collection terminal 120 is one end of fiber optics line, and the other end of the fiber optics line connects
Connect spectrometer 300.In this way, the spectrometer 300 is directly entered by the light that the fiber optics line acquires, so as to the spectrum
Instrument 300 is analyzed.
Wherein, the fiber optics line that the light collection terminal 120 uses is the fiber optics line of existing middle general type, slightly
Carefully it is not particularly limited.
In this present embodiment, the light source transmitting terminal 110 is also one end of fiber optics line, and the other end connects light source transmitting
Device, for example, laser etc..
Wherein, as shown in Fig. 2, the fiber optics line that the light source transmitting terminal 110 is selected can not be with the light collection terminal
The fiber optics line type specification of 120 selections is identical, the fiber optics line type specification that can also be selected with the light collection terminal 120
It is identical, it is not specially limited herein.
That is, in this present embodiment, one end port of multiple fiber optics lines forms gloved-figer Raman light collection
One end port of the light collecting part of device, a fiber optics line being located at finger tip forms gloved-figer Raman light collector
Light emitting portion.
In this present embodiment, the light source transmitting terminal 110 is infrared light supply transmitting terminal 110.
It can be seen that the port of non-invasive blood glucose meter Raman light collector 100 in the present embodiment by many fiber optics
A finger-stall is formed, wherein a fiber optics provides infrared light supply, Raman photon is scattered from finger end to all directions, by
The port of fiber optics clump composition is collected, and is transmitted to the input port of spectrometer 300, is analyzed for spectrometer 300.Wherein, incident light
Any one possible position re-emits after being absorbed to all directions on into the straight line path behind finger end, Raman photon
For launch point on the straight line path of incident light, being absorbed there there is exactly launch point.
The embodiment of the present invention also provides a kind of blood glucose meter, including non-invasive blood glucose meter Raman light collection as described above
Device 100.Above-mentioned that the non-invasive blood glucose meter Raman light collector 100 is described in detail, details are not described herein.
Embodiment 2
As shown in figure 3, the embodiment of the present invention also provides a kind of non-invasive blood glucose meter Raman light acquisition method, it is described non-
Invasive blood glucose meter Raman light acquisition method includes:
Step S110, in the inscribed receipts incident ray of gloved-figer Raman light collector；
Step S120 acquires Raman light of the incident ray through the finger reflection in insertion finger-stall.
The non-invasive blood glucose meter Raman light acquisition method of the present embodiment is described in detail below.
In this present embodiment, the non-invasive blood glucose meter Raman light collector 100 is in finger shell-like, inscribed in finger-stall
It receives incident ray and acquires the Raman light of finger reflection of the incident ray through being inserted into the finger-stall.
Wherein, the non-invasive blood glucose meter Raman light collector 100 when in use, gloved-figer Raman light collector
It covers on the finger 200 of user, in the inscribed receipts incident ray of finger-stall and acquires the incident ray through being inserted into the finger-stall
The Raman light that interior finger 200 reflects.
Specifically, in this present embodiment, the non-invasive blood glucose meter Raman light collector 100 includes to the finger-stall
A light source transmitting terminal 110 and the acquisition incident ray for interior transmitting predetermined beam is adopted through multiple light that finger 200 reflects
Collect end 120.
Further, in this present embodiment, the port of multiple light collection terminals 120 and the light source transmitting terminal
110 port close-packed arrays form the inner surface of the finger-stall.
That is, in this present embodiment, the non-invasive blood glucose meter Raman light collector 100 is by multiple light
The port close-packed arrays of the port of line collection terminal 120 and the light source transmitting terminal 110 are constituted in finger shell-like.
The hand of the port close-packed arrays composition of the port and light source transmitting terminal 110 of multiple light collection terminals 120
The diameter of fingerstall is matched with 200 size of finger of ordinary person, when finger 200 protrudes into the finger-stall, 200 surface of finger with
The finger-stall abutting is advisable.The length of the finger-stall is 1cm to 10cm, for example, finger tip to the length between articulations digitorum manus.
Do not limit the length of the finger-stall specifically herein, user can choose the finger of suitable length according to the principle of the present embodiment
Set.
In this present embodiment, wherein the port of the light source transmitting terminal 110 is one, it is preferable that the light source transmitting terminal
110 are located at the corresponding fingertip location of the finger-stall.
As it can be seen that the whole port by multiple light collection terminals 120 of the finger-stall surrounds and forms, multiple light
The port of collection terminal 120 constitutes the inner surface of the finger-stall, and the inner surface of entire finger-stall can acquire in finger-stall
Light.
In this way, the light that emits of the light source transmitting terminal 110 is from gloved-figer non-invasive blood glucose meter Raman light collection
Cavity emissivity at from the finger tip of device 100 to the finger-stall, the port of the light collection terminal 120 of the inner surface of entire finger-stall
The light in finger-stall can be acquired, so the Raman light collector of the present embodiment can collect the scattering light of all directions
Son enhances the intensity of Raman light, while also shielding the interference of extraneous infrared light.
In this present embodiment, the light collection terminal 120 is one end of fiber optics line, and the other end of the fiber optics line connects
Connect spectrometer 300.In this way, the spectrometer 300 is directly entered by the light that the fiber optics line acquires, so as to the spectrum
Instrument 300 is analyzed.
Wherein, the fiber optics line that the light collection terminal 120 uses is the fiber optics line of existing middle general type, slightly
Carefully it is not particularly limited.
In this present embodiment, the light source transmitting terminal 110 is also one end of fiber optics line, and the other end connects light source transmitting
Device, for example, laser etc..
Wherein, as shown in Fig. 2, the fiber optics line that the light source transmitting terminal 110 is selected can not be with the light collection terminal
The fiber optics line type specification of 120 selections is identical, the fiber optics line type specification that can also be selected with the light collection terminal 120
It is identical, it is not specially limited herein.
That is, in this present embodiment, one end port of multiple fiber optics lines forms gloved-figer Raman light collection
One end port of the light collecting part of device, a fiber optics line being located at finger tip forms gloved-figer Raman light collector
Light emitting portion.
In this present embodiment, the light source transmitting terminal 110 is infrared light supply transmitting terminal 110.
It can be seen that the port of non-invasive blood glucose meter Raman light collector 100 in the present embodiment by many fiber optics
A finger-stall is formed, wherein a fiber optics provides infrared light supply, Raman photon is scattered from finger end to all directions, by
The port of fiber optics clump composition is collected, and is transmitted to the input port of spectrometer 300, is analyzed for spectrometer 300, wherein incident light
Any one possible position re-emits after being absorbed to all directions on into the straight line path behind finger end, Raman photon
For launch point on the straight line path of incident light, being absorbed there there is exactly launch point.
In conclusion the Raman light collector in the present invention is the finger that a port by many fiber optics forms
Shape is covered, the scattered photon of all directions can be collected in this way, while also shielding the interference of extraneous infrared light, enhances Raman light
Intensity, be convenient for spectrum analysis.So the present invention effectively overcomes various shortcoming in the prior art and has high industrial
Utility value.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause
This, includes that institute is complete without departing from the spirit and technical ideas disclosed in the present invention for usual skill in technical field such as
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (11)
1. a kind of non-invasive blood glucose meter Raman light collector, which is characterized in that the non-invasive blood glucose meter Raman light collection
Device is in finger shell-like, in the inscribed receipts incident ray of finger-stall and acquires finger of the incident ray through being inserted into the finger-stall
The Raman light of reflection.
2. non-invasive blood glucose meter Raman light collector according to claim 1, which is characterized in that the non-invasive blood
Sugared instrument Raman light collector includes emitting a light source transmitting terminal and the acquisition incidence of predetermined beam into the finger-stall
Light handles multiple light collection terminals of digital reflex.
3. non-invasive blood glucose meter Raman light collector according to claim 2, which is characterized in that multiple light are adopted
The port close-packed arrays of the port and the light source transmitting terminal that collect end form the inner surface of the finger-stall.
4. non-invasive blood glucose meter Raman light collector according to claim 3, which is characterized in that the light source transmitting terminal
At the corresponding fingertip location of the finger-stall.
5. non-invasive blood glucose meter Raman light collector according to claim 2, which is characterized in that the light collection terminal
The other end for one end of fiber optics line, the fiber optics line connects spectrometer.
6. non-invasive blood glucose meter Raman light collector according to claim 2, which is characterized in that the light source transmitting terminal
For infrared light supply transmitting terminal.
7. a kind of blood glucose meter, which is characterized in that including as described in as described in claim 1 to claim 6 any claim
Non-invasive blood glucose meter Raman light collector.
8. a kind of non-invasive blood glucose meter Raman light acquisition method, which is characterized in that the non-invasive blood glucose meter Raman gloss
Set method includes:
In in the inscribed receipts incident ray of gloved-figer Raman light collector；
Acquire Raman light of the incident ray through the finger reflection in insertion finger-stall.
9. non-invasive blood glucose meter Raman light acquisition method according to claim 8, which is characterized in that the non-invasive
Blood glucose meter Raman light collector includes entering described in one light source transmitting terminal of transmitting predetermined beam and acquisition into the finger-stall
Penetrate multiple light collection terminals that light handles digital reflex.
10. non-invasive blood glucose meter Raman light acquisition method according to claim 9, which is characterized in that multiple light
The port close-packed arrays of the port of line collection terminal and the light source transmitting terminal form the inner surface of the finger-stall.
11. non-invasive blood glucose meter Raman light acquisition method according to claim 10, which is characterized in that the light source hair
End is penetrated to be located at the corresponding fingertip location of the finger-stall.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910059933.0A CN109770916A (en) | 2019-01-22 | 2019-01-22 | Non-invasive blood glucose meter Raman light acquisition method, collector and blood glucose meter |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910059933.0A CN109770916A (en) | 2019-01-22 | 2019-01-22 | Non-invasive blood glucose meter Raman light acquisition method, collector and blood glucose meter |
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| WO2000002479A1 (en) * | 1998-07-13 | 2000-01-20 | Children's Hospital Of Los Angeles | Non-invasive glucose monitor |
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| US20170188899A1 (en) * | 2016-01-04 | 2017-07-06 | Xuan Zhong Ni | Device to Collect Raman Photons for Non-Invasive Glucose Detector |
| CN108113683A (en) * | 2016-11-30 | 2018-06-05 | 三星电子株式会社 | For estimating the apparatus and method of biotic component |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000002479A1 (en) * | 1998-07-13 | 2000-01-20 | Children's Hospital Of Los Angeles | Non-invasive glucose monitor |
| JP2002085385A (en) * | 2000-09-21 | 2002-03-26 | Sadako Honda | Method and apparatus for measuring blood sugar value |
| US20030109772A1 (en) * | 2000-10-06 | 2003-06-12 | Mills Alexander K. | Method for noninvasive continuous determination of physiologic characteristics |
| US20080058622A1 (en) * | 2006-08-22 | 2008-03-06 | Baker Clark R | Medical sensor for reducing signal artifacts and technique for using the same |
| CN102928394A (en) * | 2012-10-16 | 2013-02-13 | 江苏学府医疗科技有限公司 | Portable Raman spectrum noninvasive glucose meter |
| CN106604677A (en) * | 2014-09-04 | 2017-04-26 | Rsp系统公司 | Method and apparatus for transdermal in vivo measurement by raman spectroscopy |
| CN105249974A (en) * | 2015-10-15 | 2016-01-20 | 华南师范大学 | Pressure-modulation-spectrum-technology-based noninvasive glucose detection system and method |
| US20170188899A1 (en) * | 2016-01-04 | 2017-07-06 | Xuan Zhong Ni | Device to Collect Raman Photons for Non-Invasive Glucose Detector |
| CN105796116A (en) * | 2016-05-04 | 2016-07-27 | 深圳诺康医疗设备股份有限公司 | Blood oxygen concentration collecting gloves |
| CN108113683A (en) * | 2016-11-30 | 2018-06-05 | 三星电子株式会社 | For estimating the apparatus and method of biotic component |
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Application publication date: 20190521 |