CN105662434A - Mid-infrared noninvasive blood glucose detection equipment - Google Patents
Mid-infrared noninvasive blood glucose detection equipment Download PDFInfo
- Publication number
- CN105662434A CN105662434A CN201610224789.8A CN201610224789A CN105662434A CN 105662434 A CN105662434 A CN 105662434A CN 201610224789 A CN201610224789 A CN 201610224789A CN 105662434 A CN105662434 A CN 105662434A
- Authority
- CN
- China
- Prior art keywords
- infrared
- light
- measured
- monitoring equipment
- mid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
Abstract
The invention discloses mid-infrared noninvasive blood glucose detection equipment which comprises a light source part, a detection part, a receiving part and a calculating part.The light source part is used for sending mid-infrared detection rays to the detection part, the detection part has a detection face used for making contact with an object to be detected, the mid-infrared detection rays become emergent rays carrying information of the object to be detected, the receiving part is used for receiving the emergent rays and transmitting the emergent rays to the calculating part, and the calculating part is used for calculating a blood glucose value of the object to be detected according to the emergent rays.The blood glucose detection equipment can achieve the purpose of noninvasive blood glucose testing and adopts the mid-infrared detection rays for testing, the signal-to-noise ratio in the blood glucose detection process is effectively increased, and therefore more accurate blood glucose detection is achieved.
Description
Technical field
The application relates to blood sugar test technical field, more specifically, it relates to infrared noninvasive dynamics monitoring equipment in a kind of.
Background technology
Diabetes are inner-sphere reorganization energy the most common in the world. " Chinese residents nourishment and chronic disease status report (2015) " shows, and within more than 18 years old, maturity-onset diabetes morbidity is 9.7%. China becomes undisputed diabetes first big country, and has the trend risen year by year.
In diabetics, it may also be useful to tradition has the number of invasive blood sugar instrument more than 5,000 ten thousand people, the usage quantity about 180 of year per capita of blood glucose meter test paper, annual needs the blood glucose meter test paper consumed to be about 9,000,000,000. At present owing to social life pressure is big, eating good things motion is few, often stays up late, and excessive smoking is drunk and the pollution of ecotope, causes and there is the potential patient of a large amount of diabetes in compatriots. Therefore, correct Diagnosis and Treat diabetes tool is of great significance.
Diabetic often to be carried out blood sugar concentration chemical examination during diagnosis and treatment, so that medical matters personnel are well understood to the effect for the treatment of in time. But a lot of drawback of frequently having drawn blood, had both added the danger of infection, and caused suffering to patient again, return medical matters personnel and bring certain pressure.
Therefore, how to realize the direction that noninvasive dynamics monitoring becomes researchist's effort for it. In order to change this situation, external just at the non-damage determination method of active research blood sugar concentration in recent years, comprise and use near infrared spectrum and Raman spectroscopy to carry out blood sugar monitoring. Those method spectral signal-noise ratios are low, thus utilize the accuracy of aforesaid method mensuration blood glucose value low.
Summary of the invention
For solving the problems of the technologies described above, the present invention provides infrared noninvasive dynamics monitoring equipment in one, to realize the object improving noninvasive dynamics monitoring accuracy.
For realizing above-mentioned technical purpose, embodiments provide following technical scheme:
Infrared noninvasive dynamics monitoring equipment in a kind of, comprising: light source portion, probe portion, reception portion and calculating part; Wherein,
Described light source portion is used for infrared acquisition light in the transmission of described probe portion;
Described probe portion has detection face, and described detection face is for contacting with object to be measured, and described middle infrared acquisition light becomes the outgoing light carrying object information to be measured after described probe portion;
Described reception portion is for receiving described outgoing light and transmits to described calculating part;
Described calculating part is used for the blood glucose value according to described emergent light line computation object to be measured.
Preferably, described middle infrared acquisition light is wide spectrum mid-infrared light or separate wavelengths mid-infrared light.
Preferably, described separate wavelengths mid-infrared light comprises detection light that at least a branch of wavelength is infrared signature absorption peak wavelength in glucose and at least a branch of not by the reference light of the wavelength in glucose specificabsorption wave band.
Preferably, in described glucose, the span of the wave number of infrared signature absorption peak is respectively 1155 ± 5cm-1、1080±5cm-1、1035±5cm-1、1110±5cm-1With 990 ± 5cm-1。
Preferably, the absorption peak that in described charateristic avsorption band, relational degree is the highest is 1155cm-1Absorption peak.
Preferably, described light source portion is FT-mid-IR fiber optics spectroscopy instrument or quanta cascade laser apparatus or mid-infrared laser device or wide spectrum mid-infrared light source.
Preferably, described width spectrum mid-infrared light comprises wave number scope is 400cm-1-4000cm-1Wave band or wave number scope are 400cm-1-4000cm-1Mid-infrared light in the anyon wave band of wave band.
Preferably, described object information to be measured is object to be measured to the absorption spectrum of described width spectrum mid-infrared light or object to be measured to the absorbancy of described separate wavelengths mid-infrared light.
Preferably, described object to be measured is human body surface.
Preferably, described object to be measured is human body epipharynx mucous membrane or ear-lobe surface.
Preferably, described calculating part is used for according to described object information to be measured, utilizes glucose the absorbancy of the middle infrared acquisition light of different wave length is analyzed the blood glucose value obtaining object to be measured or utilizes partial least square method (PLS) regression analysis to obtain the blood glucose value of object to be measured.
Preferably, described calculating part is used for according to described object information to be measured, by carrying out difference processing with reference concentration blood sugar sample and utilize glucose the absorbancy of the middle infrared acquisition light of different wave length to be analyzed the blood glucose value obtaining object to be measured or by carrying out difference processing with reference concentration blood sugar sample and utilize partial least square method (PLS) regression analysis to obtain the blood glucose value of object to be measured; The method adopting difference processing is to make material in addition to glucose that the impact of signal processing is minimum.
Preferably, described calculating part is used for according to described object information to be measured, by analyzing the charateristic avsorption band of glucose, any one or any number of being combined through chosen in described charateristic avsorption band carries out difference processing with reference concentration blood sugar sample and utilizes glucose that the absorbancy of the middle infrared acquisition light of different wave length is analyzed the blood glucose value obtaining object to be measured.
Preferably, described reception portion is mid-infrared light spectrometer or photoelectric probe.
Preferably, described reception portion is FT-mid-IR fiber optics spectroscopy instrument or Te-Cd-Hg photoelectric probe.
Preferably, described probe portion all make through one of middle infrared acquisition light surface that total reflection occurs or the arbitrary combination on these surfaces be described detection face;
Described middle infrared acquisition light is totally reflected at least one times through described detection face, obtains object information to be measured.
Preferably, it is 1-19 that described middle infrared acquisition light is totally reflected the span of number of times through described detection face, comprises endpoint value.
Preferably, described probe portion is trapezoidal prism.
Preferably, described trapezoidal prism is zinc sulphide prism or diamond prism or silicon prism or germanium prism.
Preferably, described blood sugar test equipment also comprises pressure detection module, for detecting the pressure that described probe portion is applied on described object to be measured, and keeps described pressure-stabilisation so that blood sugar test reliablely and stablely carries out.
From technique scheme it may be seen that embodiments provide infrared noninvasive dynamics monitoring equipment one. In described, light source portion described in infrared noninvasive dynamics monitoring equipment utilization is to infrared acquisition light in the transmission of described probe portion; Described middle infrared acquisition light becomes the outgoing light carrying object information to be measured after described probe portion; Described outgoing light is received by described reception portion and is transferred to described calculating part; Described calculating part is according to the blood glucose value of described emergent light line computation object to be measured. Can being found by above-mentioned workflow, described blood sugar test equipment only needs to contact the detection that can carry out object blood glucose value to be measured with object to be measured, and does not need the sampling operation carrying out blood, it is achieved that the object of Woundless blood sugar test.
In addition, during described blood sugar test equipment adopts, infrared acquisition light is tested, the middle infrared spectrum that described middle infrared acquisition light produces efficiently avoid the higher order resonances of near infrared spectrum and Raman spectrum, and middle infrared spectrum has lower scattering effect and higher uptake factor compared with near infrared spectrum. Further, the basic vibration of the glucose that in utilization, infrared acquisition light can detect is stronger at the overtone of near-infrared band than glucose, sharper keen and there is good isolatism, therefore in utilizing, infrared acquisition light carries out the signal to noise ratio that blood sugar test improves testing process effectively, such that it is able to realize more accurate blood sugar test.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, it is briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only embodiments of the invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, it is also possible to obtain other accompanying drawing according to the accompanying drawing provided.
Fig. 1 for the application the 1st embodiment provide a kind of in the structural representation of infrared noninvasive dynamics monitoring equipment;
The structural representation of a kind of probe portion that Fig. 2 provides for the application the 1st embodiment;
Fig. 3 is human body surface middle infrared absorption spectrum schematic diagram;
Fig. 4 is the partial enlargement schematic diagram of human body surface middle infrared absorption spectrogram;
Fig. 5 is that a kind of difference spectrum schematic diagram corresponding to different concns blood glucose value using spectrum difference method to obtain is (with 1155cm in figure-1Absorption peak is example);
Fig. 6 be resistance to sugar experimenter adopt tradition blood sampling biochemical instruments blood sugar test respectively and adopt described in infrared noninvasive dynamics monitoring equipment carry out the test result schematic diagram of blood sugar test;
Fig. 7 is that resistance to sugar experimenter adopts the Clarke of the test result that infrared noninvasive dynamics monitoring equipment carries out blood sugar test in tradition blood sampling biochemical instruments blood sugar test and employing to analyze schematic diagram respectively.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is only the present invention's part embodiment, instead of whole embodiments. Based on the embodiment in the present invention, those of ordinary skill in the art, not making other embodiments all obtained under creative work prerequisite, belong to the scope of protection of the invention.
1. the 1st embodiment
In described, infrared noninvasive dynamics monitoring equipment comprises, as shown in Figure 1: light source portion 100, probe portion 200, reception portion 300 and calculating part 400;Wherein,
Described light source portion 100 is for infrared acquisition light in the transmission of described probe portion 200;
Described probe portion 200 has detection face, and described detection face is for contacting with object to be measured, and described middle infrared acquisition light becomes the outgoing light carrying object information to be measured after described probe portion 200;
Described reception portion 300 is for receiving described outgoing light and transmits to described calculating part 400;
Described calculating part 400 is for the blood glucose value according to described emergent light line computation object to be measured.
In the present embodiment, described light source portion 100 is FT-mid-IR fiber optics spectroscopy instrument, and as shown in Figure 2, described probe portion 200 is the trapezoidal prism of zinc sulphide. Described reception portion 300 is Te-Cd-Hg probe.
Light source portion 100 launches 400cm successively-1To 4000cm-1The middle infrared acquisition light of each wavelength in wave band, between the middle infrared acquisition light of adjacent twice emitting, wave number is spaced apart the resolving power of FT-mid-IR fiber optics spectroscopy instrument.
The one end of middle infrared acquisition light infrared hollow optic fibre 600 in parabolic reflector mirror 500 focuses on that described light source portion 100 sends, is collected by infrared hollow optic fibre 600 in described and sends described probe portion 200 to. In passing through between described probe portion 200 with described reception portion 300, infrared hollow optic fibre 600 is connected. Above-mentioned middle infrared acquisition light produces evanescent wave in the total reflection process of described probe portion 200 in described detection face, object to be measured is (in the present embodiment, object to be measured is human body epipharynx mucomembranous surface) to the different wave length selective absorbing of described evanescent wave, after the transmission of hollow optic fibre 600 infrared in described, described reception portion 300 is entered by the outgoing light carrying object information to be measured of described probe portion 200 outgoing, obtaining the middle infrared absorption spectrum of object to be measured, described absorption spectrum is transferred to described calculating part 400 and carries out blood sugar concentration analysis. But in other embodiments of the application, the middle infrared acquisition light that described light source portion 100 sends can also directly enter probe portion 200 without the gathering of described parabolic reflector mirror 500; And infrared hollow optic fibre 600 can also be optical fiber or the light carrying device of other kinds in described.
Described calculating part 400 uses method that Difference Absorption composes by glucose is analyzed the blood glucose value obtaining object to be measured to the absorbancy of the middle infrared acquisition light of different wave length. In the present embodiment, described calculating part 400 is 1155cm by contrast wave number-1Difference absorbancy obtain blood glucose value. Described calculating part 400 stores referenced absorbance, is designated as AR(v), the middle infrared absorption spectrum that when described referenced absorbance is respectively object reference concentration blood glucose value to be measured, measurement obtains. In calculating part 400, monitoring by reception portion 300 being obtained the summation of infrared acquisition light power in all wavelengths, ensureing that it is constant, thus carry out stdn to measuring the absorption spectrum obtained. The absorption spectrum discussed hereinafter is all through standardization. Described object information to be measured, for measuring absorption spectrum, is designated as AS(v). As shown in Figure 3, being typical human body surface middle infrared absorption spectrogram, Fig. 4 is the partial enlargement figure of Fig. 3. The measurement absorption spectrum of corresponding wavelength and referenced absorbance are subtracted each other, obtains Difference Absorption spectrum, be designated as AD(v), AD(v)=AS(v)-AR(v). The method adopting Difference Absorption spectrum is to make material in addition to glucose that the impact of signal processing is minimum. As shown in Figure 5, the difference spectrum schematic diagram corresponding to different concns blood glucose value using spectrum difference method to obtain is illustrated (with 1155cm in figure-1Peak is example).
According to Law of Lambert-Beer A (v)=log (T0/T1)=abc, in formula, A (v) is in the middle infrared absorption spectrum recorded, and wave number is the absorbancy of the mid-infrared light of v. T0For described probe portion 200 contact with object to be measured before transmitted light intensity, T1For described probe portion 200 contact with object to be measured after transmitted light intensity, a is the uptake factor of test substance, and b is light path, and c is the concentration of test substance. Choose 1155cm-1The difference absorbance A at peak placeD(1155) as the tolerance of blood sugar concentration. By formula G=g+k × AD(1155) blood glucose value is obtained. In formula, G is blood glucose value, g and k is calibration factor, calibration factor be described in the infrared built-in coefficient of noninvasive dynamics monitoring equipment, obtain by previous experiments.
In the process of blood sugar test, the pressure that modular pressure 700 is applied on object 800 to be measured for detecting probe portion 200, and keep described pressure-stabilisation so that blood sugar test reliablely and stablely carries out.
It should be understood that
Present embodiments provide a kind of by utilizing glucose that the absorbancy of the middle infrared acquisition light of different wave length is analyzed the method for the blood glucose value obtaining object to be measured. When the separate wavelengths mid-infrared light that described middle infrared acquisition light is wide spectrum mid-infrared light or other wave numbers, only need aforesaid method is carried out corresponding change, but the application is to utilizing, and the concrete grammar that the absorbancy of the middle infrared acquisition light of different wave length is analyzed the blood glucose value obtaining object to be measured depending on practical situation, can be not limited to aforesaid method by glucose.
Detection selected by infrared noninvasive dynamics monitoring equipment and analyze light in described in the application is based upon on basis that human body surface absorption spectrum analyzes. As shown in Figure 3, being typical human body surface middle infrared absorption spectrogram, Fig. 4 is the partial enlargement figure of Fig. 3. The 1080cm that from Fig. 3 and Fig. 4 it may be seen that in described glucose, the wave number of infrared signature absorption peak is mainly in glucose C-O key effect and is formed-1And 1035cm-1, and the 1155cm of C-C key and C-O key acting in conjunction formation-1、1100cm-1And 990cm-1These five absorption peaks. Owing to absorption peak has one fixed width, therefore in other embodiments of the application, in described glucose, the span of the wave number of infrared signature absorption peak is respectively 1155 ± 5cm-1、1080±5cm-1、1035±5cm-1、1110±5cm-1With 990 ± 5cm-1. The concrete value of the wave number of infrared signature absorption peak in described glucose is not limited by the application, specifically depending on practical situation. Can being drawn by test, the absorption peak that wherein relational degree is higher is 1080cm-1And 1155cm-1These two absorption peaks. Wherein come from the 1155cm of glucose ring texture-1Peak relational degree is the highest. Described relational degree represents the degree that absorption peak changes with blood sugar concentration in object to be measured, and absorption peak changes more greatly with blood sugar concentration in object to be measured, then illustrate that the relational degree of this absorption peak is more high. In the actual application of described blood sugar test equipment, it is preferable that wavelength be the absorption peak place wavelength that relational degree is high middle infrared acquisition light as described detection light and calculating part 400 wavelength of weight analysis.
In the selection of light source portion 100, the described light source portion 100 of the present embodiment have employed FT-mid-IR fiber optics spectroscopy instrument. It is 400cm that described infrared spectrometer can send wave number scope-1To 4000cm-1Wave band in any Single wavelength mid-infrared light, it is also possible to sending wave number scope is 400cm-1To 4000cm-1Wave band or the mid-infrared light of its wavelet section. In other embodiment of the application, light source can also select middle INFRARED QUANTUM CASCADE LASERS or wide spectrum mid-infrared light source.
In the selection of probe portion 200, described trapezoidal prism can be zinc sulphide prism or diamond prism or silicon prism or germanium prism.One of all surfaces that can make middle infrared acquisition light that total reflection occurs of described trapezoidal prism all can be used as described detection face, such as surperficial S2 or S3 shown in Fig. 2; The arbitrary combination on all surfaces that can make middle infrared acquisition light that total reflection occurs can also as described detection face in addition, the such as combination of surperficial S2 and S3 shown in Fig. 2. The trapezoidal prism that the application uses makes detection light repeatedly be totally reflected via prism, can improve signal to noise ratio to a great extent. It is 1-19 that described middle infrared acquisition light is totally reflected the span of number of times through described detection face, comprises endpoint value. It is more many that described middle infrared acquisition light is totally reflected number of times through described detection face, the information of its object to be measured obtained is more many, but it is more many that described middle infrared acquisition light is totally reflected number of times through described detection face, and the strength retrogression of described middle infrared acquisition light is more many. Therefore need it to be tested before above-mentioned blood sugar test equipment use, obtain the total reflection number of times of optimum middle infrared acquisition light through described detection face. But owing to the selection combined in light source portion 100, probe portion 200, trapezoidal prism material and reception portion 300 is different, the difference of sensitivity, causes the total reflection number of times of optimum middle infrared acquisition light through described detection face different. Through described detection face, described middle infrared acquisition light is totally reflected the application the concrete value of number of times and span does not limit, specifically depending on practical situation.
The embodiment of the present application provide described in the design measuring point of infrared noninvasive dynamics monitoring equipment be human skin, it is preferable to human body epipharynx mucomembranous surface or ear-lobe are surperficial. This is because the penetration depth of mid-infrared light is very little, in human body, the stratum corneum of Mucosa of lip or ear-lobe skin is thinner, the obstruction degree of centering infrared acquisition light is less, it is preferred to by surperficial to human body epipharynx mucomembranous surface or ear-lobe and the Contact test of described probe portion 200, to obtain better blood sugar test effect. But this is not limited by the application, specifically depending on practical situation.
In the selection in reception portion 300, described reception portion can use Te-Cd-Hg photoelectric probe or other photoelectric probe, it is possible to use FT-mid-IR fiber optics spectroscopy instrument or other mid-infrared light spectrometer.
2. the 2nd embodiment
On the basis of above-described embodiment, in the present embodiment, described light source portion 100 is quanta cascade laser apparatus, launches the middle infrared acquisition light of discrete wavelength, and comprising wave number is 1155cm-1Detection light and wave number be 1500cm-1Ginseng compare light. Described calculating part 400 uses method that Difference Absorption composes by glucose is analyzed the blood glucose value obtaining object to be measured to the absorbancy of the middle infrared acquisition light of different wave length. In the present embodiment, described calculating part 400 is 1155cm by contrast wave number-1Difference absorbancy obtain blood glucose value. Described calculating part 400 stores referenced absorbance, is designated as [AR(1155), AR], (1500) the middle infrared absorption spectrum that when described referenced absorbance is respectively object reference concentration blood glucose value to be measured, measurement obtains. Utilize ginseng, than optical absorbance, original measurement absorption spectrum is carried out stdn, it is multiplied by original measurement absorption spectrum with normalisation coefft, make the ginseng of the measurement absorption spectrum after stdn more equal than optical absorbance with the ginseng of referenced absorbance than optical absorbance. The measurement absorption spectrum later discussed is the absorption spectrum after stdn. Described object information to be measured, for measuring absorption spectrum, is designated as [AS(1155), AS(1500)].The measurement absorption spectrum of corresponding wavelength and referenced absorbance are subtracted each other, obtains Difference Absorption spectrum, be designated as [AD(1155), 0]. Described calculating part 400 is by formula G=g+k × AD(1155) blood glucose value G is obtained.
It should be noted that, in the various embodiments described above, the detection light that described light source portion 100 sends at least comprises place, described glucose specificabsorption peak wavelength. The reference light that described light source portion 100 sends at least comprises one not by the wavelength in glucose specificabsorption wave band, as shown in Figure 2, and such as 1200cm-1-1800cm-1And 2000cm-1-2700cm-1Deng the wavelength in wave band. But the concrete wavelength value of described detection light and reference light is not limited by the application, specifically depending on practical situation.
3. the 3rd embodiment
On the basis of above-described embodiment, in the present embodiment, light source portion 100 is FT-mid-IR fiber optics spectroscopy instrument. Described calculating part 400 uses method that Difference Absorption composes by glucose is analyzed the blood glucose value obtaining object to be measured to the absorbancy of the middle infrared acquisition light of different wave length. In the present embodiment, described calculating part 400 is 1155cm by contrast wave number-1Difference absorbancy and wave number be 1080cm-1Difference absorbancy obtain blood glucose value.
4. the 4th embodiment
On the basis of above-described embodiment, in the present embodiment, described light source portion 100 is wide spectrum mid-infrared light source. Launch light width spectrum mid-infrared light (400cm-1To 4000cm-1Wave band, namely 2.5 microns to 25 micron wavebands). Described reception portion 300 is FT-mid-IR fiber optics spectroscopy instrument. Described calculating part 400 utilizes the method that Difference Absorption composes, and by partial least squares regression (PLS) to absorption spectrum modeling, holistic approach, obtains blood glucose value.
It should be noted that, wide spectrum mid-infrared light source can be launched and comprises 400cm-1To 4000cm-1The light of wave band or its wavelet section. The wide spectrum mid-infrared light source of light source portion 100 can be replaced FT-mid-IR fiber optics spectroscopy instrument herein, and the FT-mid-IR fiber optics spectroscopy instrument in reception portion 300 can be replaced photoelectric probe.
In described in the application, infrared noninvasive dynamics monitoring equipment is to the result of resistance to sugar experimenter's blood sugar test as shown in Figure 6, and the X-coordinate of accompanying drawing 6 is the time that resistance to sugar experimenter accepts resistance to sugar test, and ordinate zou is blood glucose value. Data point wherein is respectively reference value and the prophesy value of resistance to sugar experimenter blood sugar within acceptance resistance to sugar test for some time. Wherein reference value is the blood glucose value of biochemical test after resistance to sugar experimenter being taken a blood sample, it will be recognized which represent the accurate blood glucose level data of resistance to sugar this time point of experimenter; Prophesy value utilize described in the blood sugar test equipment that provides of infrared noninvasive dynamics monitoring equipment at identical time point, resistance to sugar experimenter is carried out the blood glucose level data of blood sugar test. Can find that the error of described prophesy value and described reference value is very little, it is possible to react the blood glucose value of resistance to sugar experimenter comparatively accurately.
Fig. 7 is the schematic diagram utilizing described prophesy value in Fig. 6 and reference value to carry out Clarke grid analysis, and X-coordinate is described reference value, and ordinate zou is described prophesy value. The clinical precise area of A region representation in Fig. 7. Can be found by Fig. 7, utilize the blood glucose reference value of described blood sugar test equipment Inspection all in clinical precise area, the blood glucose value utilizing described blood sugar test equipment can detect object to be measured comparatively accurately is described.
In sum, the embodiment of the present application provides infrared noninvasive dynamics monitoring equipment in one. In described, light source portion described in infrared noninvasive dynamics monitoring equipment utilization is to infrared acquisition light in the transmission of described probe portion;Described middle infrared acquisition light becomes the outgoing light carrying object information to be measured after described probe portion; Described outgoing light is received by described reception portion and is transferred to described calculating part; Described calculating part is according to the blood glucose value of described emergent light line computation object to be measured. Can being found by above-mentioned workflow, described blood sugar test equipment only needs to contact the detection that can carry out object blood glucose value to be measured with object to be measured, and does not need the sampling operation carrying out blood, it is achieved that the object of Woundless blood sugar test.
In addition, during described blood sugar test equipment adopts, infrared acquisition light is tested, the middle infrared spectrum that described middle infrared acquisition light produces efficiently avoid the higher order resonances of near infrared spectrum and Raman spectrum, and middle infrared spectrum has lower scattering effect and higher uptake factor compared with near infrared spectrum. Further, the basic vibration of the glucose that in utilization, infrared acquisition light can detect is stronger at the overtone of near-infrared band than glucose, sharper keen and there is good isolatism, therefore in utilizing, infrared acquisition light carries out the signal to noise ratio that blood sugar test improves testing process effectively, such that it is able to realize more accurate blood sugar test.
To the above-mentioned explanation of the disclosed embodiments, professional and technical personnel in the field are enable to realize or use the present invention. To be apparent for those skilled in the art to the multiple amendment of these embodiments, General Principle as defined herein can without departing from the spirit or scope of the present invention, realize in other embodiments. Therefore, the present invention can not be limited in these embodiments shown in this article, but be met the widest scope consistent with principle disclosed herein and features of novelty.
Claims (20)
1. infrared noninvasive dynamics monitoring equipment in one kind, it is characterised in that, comprising: light source portion, probe portion, reception portion and calculating part; Wherein,
Described light source portion is used for infrared acquisition light in the transmission of described probe portion;
Described probe portion has detection face, and described detection face is for contacting with object to be measured, and described middle infrared acquisition light becomes the outgoing light carrying object information to be measured after described probe portion;
Described reception portion is for receiving described outgoing light and transmits to described calculating part;
Described calculating part is used for the blood glucose value according to described emergent light line computation object to be measured.
2. infrared noninvasive dynamics monitoring equipment according to claim 1, it is characterised in that, described middle infrared acquisition light is wide spectrum mid-infrared light or separate wavelengths mid-infrared light.
3. infrared noninvasive dynamics monitoring equipment according to claim 2, it is characterized in that, described separate wavelengths mid-infrared light comprises detection light that at least a branch of wavelength is infrared signature absorption peak wavelength in glucose and at least a branch of not by the reference light of the wavelength in glucose specificabsorption wave band.
4. infrared noninvasive dynamics monitoring equipment according to claim 3, it is characterised in that, in described glucose, the span of the wave number of infrared signature absorption peak is respectively 1155 ± 5cm-1、1080±5cm-1、1035±5cm-1、1110±5cm-1With 990 ± 5cm-1。
5. infrared noninvasive dynamics monitoring equipment according to claim 4, it is characterised in that, the absorption peak that in described charateristic avsorption band, relational degree is the highest is 1155cm-1Absorption peak.
6. infrared noninvasive dynamics monitoring equipment according to claim 1, it is characterised in that, described light source portion is FT-mid-IR fiber optics spectroscopy instrument or quanta cascade laser apparatus or mid-infrared laser device or wide spectrum mid-infrared light source.
7. infrared noninvasive dynamics monitoring equipment according to claim 2, it is characterised in that, it is 400cm that described width spectrum mid-infrared light comprises wave number scope-1-4000cm-1Wave band or wave number scope are 400cm-1-4000cm-1Mid-infrared light in the anyon wave band of wave band.
8. infrared noninvasive dynamics monitoring equipment according to claim 1, it is characterised in that, described object information to be measured is object to be measured to the absorption spectrum of described width spectrum mid-infrared light or object to be measured to the absorbancy of described separate wavelengths mid-infrared light.
9. infrared noninvasive dynamics monitoring equipment according to claim 8, it is characterised in that, described object to be measured is human body surface.
10. infrared noninvasive dynamics monitoring equipment according to claim 9, it is characterised in that, described object to be measured is human body epipharynx mucous membrane or ear-lobe surface.
11. according to claim 1 in infrared noninvasive dynamics monitoring equipment, it is characterized in that, described calculating part is used for according to described object information to be measured, utilizes glucose the absorbancy of the middle infrared acquisition light of different wave length is analyzed the blood glucose value obtaining object to be measured or utilizes partial least square method (PLS) regression analysis to obtain the blood glucose value of object to be measured.
12. according to claim 11 in infrared noninvasive dynamics monitoring equipment, it is characterized in that, described calculating part is used for according to described object information to be measured, by carrying out difference processing with reference concentration blood sugar sample and utilize glucose the absorbancy of the middle infrared acquisition light of different wave length to be analyzed the blood glucose value obtaining object to be measured or by carrying out difference processing with reference concentration blood sugar sample and utilize partial least square method (PLS) regression analysis to obtain the blood glucose value of object to be measured; The method adopting difference processing is to make material in addition to glucose that the impact of signal processing is minimum.
13. according to claim 12 in infrared Woundless blood sugar monitoring equipment, it is characterized in that, described calculating part is used for according to described object information to be measured, by analyzing the charateristic avsorption band of glucose, any one or any number of being combined through chosen in described charateristic avsorption band carries out difference processing with reference concentration blood sugar sample and utilizes glucose that the absorbancy of the middle infrared acquisition light of different wave length is analyzed the blood glucose value obtaining object to be measured.
14. according to claim 1 in infrared noninvasive dynamics monitoring equipment, it is characterised in that, described reception portion is mid-infrared light spectrometer or photoelectric probe.
15. according to claim 14 in infrared noninvasive dynamics monitoring equipment, it is characterised in that, described reception portion is FT-mid-IR fiber optics spectroscopy instrument or Te-Cd-Hg photoelectric probe.
16. according to claim 1 in infrared noninvasive dynamics monitoring equipment, it is characterised in that, described probe portion all make through one of middle infrared acquisition light surface that total reflection occurs or the arbitrary combination on these surfaces be described detection face;
Described middle infrared acquisition light is totally reflected at least one times through described detection face, obtains object information to be measured.
17. according to claim 16 in infrared noninvasive dynamics monitoring equipment, it is characterised in that, described middle infrared acquisition light through described detection face be totally reflected number of times span be 1-19, comprise endpoint value.
18. according to claim 16 or 17 in infrared noninvasive dynamics monitoring equipment, it is characterised in that, described probe portion is trapezoidal prism.
19. according to claim 18 in infrared noninvasive dynamics monitoring equipment, it is characterised in that, described trapezoidal prism is zinc sulphide prism or diamond prism or silicon prism or germanium prism.
20. according to the arbitrary item of claim 1-17 or 19 in infrared noninvasive dynamics monitoring equipment, it is characterized in that, described blood sugar test equipment also comprises pressure detection module, for detecting the pressure that described probe portion is applied on described object to be measured, and keep described pressure-stabilisation so that blood sugar test reliablely and stablely carries out.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610224789.8A CN105662434A (en) | 2016-04-12 | 2016-04-12 | Mid-infrared noninvasive blood glucose detection equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610224789.8A CN105662434A (en) | 2016-04-12 | 2016-04-12 | Mid-infrared noninvasive blood glucose detection equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105662434A true CN105662434A (en) | 2016-06-15 |
Family
ID=56234687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610224789.8A Pending CN105662434A (en) | 2016-04-12 | 2016-04-12 | Mid-infrared noninvasive blood glucose detection equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105662434A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107174257A (en) * | 2017-04-14 | 2017-09-19 | 浙江澍源智能技术有限公司 | A kind of miniature wearable non-invasive glucose monitor |
| WO2018107915A1 (en) | 2016-12-16 | 2018-06-21 | 博邦芳舟医疗科技（北京）有限公司 | General noninvasive blood glucose prediction method based on timing analysis |
| JP2019037752A (en) * | 2017-08-23 | 2019-03-14 | 株式会社リコー | Measuring apparatus and measuring method |
| US10485431B1 (en) | 2018-05-21 | 2019-11-26 | ARC Devices Ltd. | Glucose multi-vital-sign system in an electronic medical records system |
| US10492684B2 (en) | 2017-02-21 | 2019-12-03 | Arc Devices Limited | Multi-vital-sign smartphone system in an electronic medical records system |
| US10506926B2 (en) | 2017-02-18 | 2019-12-17 | Arc Devices Limited | Multi-vital sign detector in an electronic medical records system |
| US10602987B2 (en) | 2017-08-10 | 2020-03-31 | Arc Devices Limited | Multi-vital-sign smartphone system in an electronic medical records system |
| CN113260849A (en) * | 2019-01-31 | 2021-08-13 | 国立大学法人东北大学 | Blood sugar level measuring device and blood sugar level measuring method |
| WO2021169551A1 (en) * | 2020-02-24 | 2021-09-02 | 京东方科技集团股份有限公司 | Physical sign parameter detection device and physical sign parameter detection method |
| US11504014B2 (en) | 2020-06-01 | 2022-11-22 | Arc Devices Limited | Apparatus and methods for measuring blood pressure and other vital signs via a finger |
| CN116337803A (en) * | 2023-01-10 | 2023-06-27 | 中南民族大学 | Liquid sample component detection probe, processing method and detection system |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1194133A (en) * | 1996-01-22 | 1998-09-30 | 北京大学 | Method of measuring human blood sugar by medium infrared optical fiber |
| US20030031597A1 (en) * | 2001-08-03 | 2003-02-13 | Waseda University | Apparatus for measuring glucose concentration |
| CN1555242A (en) * | 1998-10-13 | 2004-12-15 | ÷�°��յٿ�˹��˾ | Infrared attenuation full reflection measurement system |
| CN1573318A (en) * | 2003-06-02 | 2005-02-02 | 拜尔健康护理有限责任公司 | Non-invasive methods of detecting analyte concentrations using hyperosmotic fluids |
| JP2010217097A (en) * | 2009-03-18 | 2010-09-30 | Photoscience:Kk | Glucose concentration measuring apparatus |
| CN205758567U (en) * | 2016-04-12 | 2016-12-07 | 北京科宇佳科技有限公司 | A kind of mid-infrared noninvasive dynamics monitoring equipment |
-
2016
- 2016-04-12 CN CN201610224789.8A patent/CN105662434A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1194133A (en) * | 1996-01-22 | 1998-09-30 | 北京大学 | Method of measuring human blood sugar by medium infrared optical fiber |
| CN1555242A (en) * | 1998-10-13 | 2004-12-15 | ÷�°��յٿ�˹��˾ | Infrared attenuation full reflection measurement system |
| US20030031597A1 (en) * | 2001-08-03 | 2003-02-13 | Waseda University | Apparatus for measuring glucose concentration |
| CN1573318A (en) * | 2003-06-02 | 2005-02-02 | 拜尔健康护理有限责任公司 | Non-invasive methods of detecting analyte concentrations using hyperosmotic fluids |
| JP2010217097A (en) * | 2009-03-18 | 2010-09-30 | Photoscience:Kk | Glucose concentration measuring apparatus |
| CN205758567U (en) * | 2016-04-12 | 2016-12-07 | 北京科宇佳科技有限公司 | A kind of mid-infrared noninvasive dynamics monitoring equipment |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018107915A1 (en) | 2016-12-16 | 2018-06-21 | 博邦芳舟医疗科技（北京）有限公司 | General noninvasive blood glucose prediction method based on timing analysis |
| US10825569B2 (en) | 2016-12-16 | 2020-11-03 | Global Health Ark Medical Technology (Beijing) Co. Ltd | Universal non-invasive blood glucose estimation method based on time series analysis |
| US10506926B2 (en) | 2017-02-18 | 2019-12-17 | Arc Devices Limited | Multi-vital sign detector in an electronic medical records system |
| US10667688B2 (en) | 2017-02-21 | 2020-06-02 | ARC Devices Ltd. | Multi-vital sign detector of SpO2 blood oxygenation and heart rate from a photoplethysmogram sensor and respiration rate, heart rate variability and blood pressure from a micro dynamic light scattering sensor in an electronic medical records system |
| US10492684B2 (en) | 2017-02-21 | 2019-12-03 | Arc Devices Limited | Multi-vital-sign smartphone system in an electronic medical records system |
| CN107174257A (en) * | 2017-04-14 | 2017-09-19 | 浙江澍源智能技术有限公司 | A kind of miniature wearable non-invasive glucose monitor |
| US10602987B2 (en) | 2017-08-10 | 2020-03-31 | Arc Devices Limited | Multi-vital-sign smartphone system in an electronic medical records system |
| CN111050645A (en) * | 2017-08-23 | 2020-04-21 | 株式会社理光 | Measuring device and measuring method |
| US20200170553A1 (en) * | 2017-08-23 | 2020-06-04 | Ryosuke Kasahara | Measuring apparatus and measuring method |
| JP2019037752A (en) * | 2017-08-23 | 2019-03-14 | 株式会社リコー | Measuring apparatus and measuring method |
| US10485431B1 (en) | 2018-05-21 | 2019-11-26 | ARC Devices Ltd. | Glucose multi-vital-sign system in an electronic medical records system |
| CN113260849A (en) * | 2019-01-31 | 2021-08-13 | 国立大学法人东北大学 | Blood sugar level measuring device and blood sugar level measuring method |
| WO2021169551A1 (en) * | 2020-02-24 | 2021-09-02 | 京东方科技集团股份有限公司 | Physical sign parameter detection device and physical sign parameter detection method |
| US11504014B2 (en) | 2020-06-01 | 2022-11-22 | Arc Devices Limited | Apparatus and methods for measuring blood pressure and other vital signs via a finger |
| CN116337803A (en) * | 2023-01-10 | 2023-06-27 | 中南民族大学 | Liquid sample component detection probe, processing method and detection system |
| CN116337803B (en) * | 2023-01-10 | 2024-01-02 | 中南民族大学 | Liquid sample component detection probe, processing method and detection system |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105662434A (en) | Mid-infrared noninvasive blood glucose detection equipment | |
| JP4212007B2 (en) | Blood component concentration analyzer | |
| JP4936203B2 (en) | Glucose concentration determination device | |
| US6466807B1 (en) | Optical glucose detector | |
| US11147482B2 (en) | Method and system for non-invasive blood glucose measurement using signal change of the non-glucose components induced by the presence of glucose | |
| US8406839B2 (en) | Method and apparatus for determining blood analytes | |
| US7961304B2 (en) | Optical device components | |
| CA2216641A1 (en) | Apparatus and methods of raman spectroscopy for analysis of blood gases and analytes | |
| US20080144004A1 (en) | Optical Spectrophotometer | |
| JP4472794B2 (en) | Glucose concentration determination device | |
| US20190380630A1 (en) | Noninvasive mid-infrared in vivo glucose sensor | |
| KR20090036996A (en) | Non-prick based glucose sensor combining transmittance and reflectance using single wavelength with diverse light sources | |
| US20230148312A1 (en) | Device for non-invasive blood glucose concentration measurement | |
| Priyoti et al. | Non-invasive blood glucose measurement using near infra-red spectroscopy | |
| CN205758567U (en) | A kind of mid-infrared noninvasive dynamics monitoring equipment | |
| JP4120684B2 (en) | Blood component concentration analyzer by spectroscopic analysis | |
| JP2017140159A (en) | Non-invasive blood glucose level measuring method using infrared spectroscopy | |
| CN105232055A (en) | Noninvasive glucometer | |
| KR100943095B1 (en) | The apparatus and method for real time analyzing components of urine in toilet by using minature atr infrared spectroscopy | |
| JP2023015889A (en) | measuring device | |
| CN209915953U (en) | Skin detection device | |
| KR102335211B1 (en) | Method and apparatus for measuring blood component using self-reference point establishment | |
| WO2012006618A2 (en) | Optical measurement of an analyte | |
| Hassan et al. | Label-free sensing of intrinsic biomarkers related to medical device performance employing a noninvasive fingerprint infrared spectroscopy method | |
| Gonzàlez-Viveros et al. | Transmittance and reflectance measurements of anhydrous glucose concentrations on solutions |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 100190 Beijing city Haidian District Shuangqing Road No. 3 room 3361 Applicant after: BEIJING KEYUJIA TECHNOLOGY CO., LTD. Address before: 100190 Beijing City, Haidian District Zhongguancun South Street No. 8 Applicant before: BEIJING KEYUJIA TECHNOLOGY CO., LTD. |
|
| COR | Change of bibliographic data | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160615 |