CN109770346A - A kind of nutritional health food - Google Patents
A kind of nutritional health food Download PDFInfo
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Abstract
The invention discloses a kind of nutritional health foods, are mixed by eight kinds of vegetable composition, tubers composition, grain compositions, fruit composition, nut composition, aquatic class composition, mushroom composition and meat, eggs and milk class composition compositions；Anti-aging preventing tumor is realized by the proportion of variety classes integration of drinking and medicinal herbs food, and the effect of enhancing development.
Description
Technical field
The present invention relates to field of health care food, and in particular to a kind of nutritional health food.
Background technique
Currently, China has stepped into aging society, and aging is both the performance that human life quality improves, while also band
Many social concerns are carried out, especially health problem caused by aging course becomes increasingly conspicuous, and aging of population is often adjoint
The diseases such as the raising, such as diabetes, hypertension, pulmonary emphysema, encephalatrophy, cerebral infarction, fracture of many disease incidences, these
Disease seriously affects the quality of life of the elderly, brings serious financial burden to personal, family or even country.
Aging is a kind of generally existing and extremely complex biological process, is determined jointly by environmental factor and inherent cause
It is fixed.In body normal metabolic processes, the highly reactive form of oxygen free radical of generation can damaging tissue's cell, to cope with this oxygen toxicity,
Cell prevents the generation of active oxygen by a variety of Antioxidation Mechanisms, and passes through the active oxygen in own metabolism with generation.Work as activity
When the production quantity of oxygen is more than cellular anti-oxidant capacity, cell will appear oxidativestress damage just to which aging occur.Active oxygen is also
Have the function of adjusting the expression such as antibody, cell factor and secretion in immunoreaction process, due to the structure of immunocyte fragility
Feature makes it be easier to that oxidativestress damage occurs than other cells.In addition, oxygen radical is the effector of body inflammatory reaction,
Excessive oxidative stress can also induce the inflammatory reaction of body through a variety of ways.Therefore, in aging course, body is located for a long time
In low chronic inflammatory state and with the low of body's immunity, oxidative stress-is immune-inflammation be cause aging and
The main drive of common diseases associated with senescence, current many indexs of correlation have been used as the marker of aging, pass through anti-oxidant, suppression
Inflammation processed and adjust the prognosis that can delay senescence and be obviously improved diseases associated with senescence such as immune.
There are many antiaging agent for having now been found that or synthesizing, and Chinese medicine and plurality of herbal formula are considered very promising
Antiaging agent.Wherein, Astragaloside IV, Herba Cistanches, curcumin, tetrahydro curcumin, Quercetin, lutein, berberine, catechu
The components such as element, curcumin, nutgall catechin, Gastrodin all have good anti-aging effects.Chinese medicine is particular about " integration of drinking and medicinal herbs ",
" there's no such thing as a totally safe medicine " is a kind of acceptable anti-by " tonic " for increasingly focusing on the elderly of health and green living
Aging method.
Summary of the invention
The object of the present invention is to provide nutrient and healthcare products, are realized by the proportion of variety classes integration of drinking and medicinal herbs food anti-ageing
Old preventing tumor, and the effect of enhancing development.
To achieve the above object the invention discloses a kind of nutritional health food, by vegetable composition, tubers composition,
Eight kinds of grain compositions, fruit composition, nut composition, aquatic class composition, mushroom composition and meat, eggs and milk class composition
Composition mixes；
Wherein weight percent shared by each composition is respectively as follows:
Vegetable composition 27 ~ 29%；
Tubers composition 19 ~ 21%；
Grain compositions 16 ~ 18%；
Fruit composition 11 ~ 13%；
Nut composition 7 ~ 9%；
Aquatic class composition 6 ~ 8%；
Mushroom composition； 3~4%
Meat, eggs and milk class composition 3 ~ 4%.
Further, wherein the vegetable composition is by rape, spinach, cauliflower, green asparagus, wax gourd, pumpkin, cucumber, eggplant
Son, tomato, one of or plurality of raw materials composition；
Wherein each weight of material number is respectively as follows: 0 ~ 3.5 part of rape, 0 ~ 2.8 part of spinach, 0 ~ 3.4 part of cauliflower, green asparagus 0 ~ 2.8
Part, 0 ~ 3.3 part of wax gourd, 0 ~ 3.2 part of pumpkin, 0 ~ 2.7 part of cucumber, 0 ~ 3.2 part of eggplant, 0 ~ 3 part of tomato.
Further, wherein the tubers composition by Chinese yam, sweet potato, potato, taro, carrot, white radishes, in
One or more raw material compositions；
Wherein each weight of material number be respectively as follows: 0 ~ 2.6 part of Chinese yam, 0 ~ 2.4 part of sweet potato, 0 ~ 4.6 part of potato, 0 ~ 4.5 part of taro,
0 ~ 3.3 part of carrot, 0 ~ 2.9 part of white radishes.
Further, wherein the grain compositions are by highland barley, millet, black rice, Semen Coicis, wheat, red bean, mung bean, silkworm
Beans, tartary buckwheat, sorghum, white peas or beans, soya bean, semen sojae atricolor, green soya bean, oat, one of or plurality of raw materials composition；
Wherein 0 ~ 0.2 part of highland barley, 0 ~ 0.8 part of millet, 0 ~ 0.4 part of black rice, 0 ~ 1.1 part of Semen Coicis, 0 ~ 0.7 part of wheat, red bean 0 ~
1.2 parts, 0 ~ 0.9 part of mung bean, 0 ~ 1.3 part of semen viciae fabae, 0 ~ 1.4 part of tartary buckwheat, 0 ~ 1.6 part of sorghum, 0 ~ 0.9 part of white peas or beans, soya bean 0 ~ 1.7
Part, 0 ~ 1.3 part of semen sojae atricolor, 0 ~ 1.9 part of green soya bean, 0 ~ 1.3 part of oat.
Further, wherein the fruit composition by yellow peach, apple, grape, banana, hawthorn, jujube, one of or
Plurality of raw materials composition；
Wherein each weight of material number be respectively as follows: 0 ~ 1.1 part of yellow peach, 0 ~ 1.7 part of apple, 0 ~ 2.7 part of grape, 0 ~ 2.8 part of banana,
0 ~ 3.2 part of hawthorn, 0 ~ 0.9 part of jujube.
Further, wherein the nut composition by walnut kernel, Semen sesami nigrum, sunflower seeds, peanut, SEMEN PINI KORAIENSIS, Chinese chestnut, in
One or more raw materials composition；
Wherein each weight of material number be respectively as follows: 0 ~ 1.2 part of walnut kernel, 0 ~ 0.7 part of Semen sesami nigrum, 0 ~ 1.4 part of sunflower seeds, peanut 0 ~
1.5 parts, 0 ~ 1.8 part of SEMEN PINI KORAIENSIS, 0 ~ 1.5 part of Chinese chestnut.
Further, wherein the aquatic class composition by sea cucumber, Gorgon fruit, water caltrop kernel, lotus rhizome, one of or a variety of originals
Material composition；
Wherein each weight of material number is respectively as follows: 0 ~ 0.4 part of sea cucumber, 0 ~ 2.1 part of Gorgon fruit, 0 ~ 1.7 part of water caltrop kernel, lotus rhizome 0 ~ 3.1
Part.
Further, wherein the mushroom composition by needle mushroom, mushroom, dried mushroom, black fungus, tremella, one of or
Plurality of raw materials composition；
Wherein each weight of material number be respectively as follows: 0 ~ 0.9 part of needle mushroom, 0 ~ 0.7 part of mushroom, 0 ~ 0.5 part of dried mushroom, black fungus 0 ~
0.8 part, 0 ~ 0.6 part of tremella.
Further, wherein the meat, eggs and milk class composition by beef, mutton, egg, donkey milk powder, one of or it is a variety of
Raw material composition；
Wherein each weight of material number is respectively as follows: 0 ~ 1.2 part of beef, 0 ~ 1.1 part of mutton, 0 ~ 1.1 part of egg, donkey milk powder 0 ~ 0.4
Part.
The invention also discloses a kind of preparation methods of nutrient and healthcare products, include the following steps:
(1), weighing；Proportionally weigh vegetable composition, tubers composition, grain compositions, fruit composition, nut group
Object, aquatic class composition, mushroom composition and meat, eggs and milk class composition material are closed as raw material for standby；
(2), vegetable composition prepare, vegetable combination raw material is cleaned, quick-boil scald obtain it is cooked, by cooked vegetables group
It closes and carries out broken acquisition vegetable composition after raw material is dried in vacuo；
(3), tubers composition prepare, tubers composition material is cleaned, quick-boil scald obtain it is cooked, by cooked
Stem class composition material carries out broken acquisition tubers composition after being dried in vacuo；
(4), prepared by grain compositions, and grain compositions raw material is cleaned, and carries out high temperature puffing, the paddy after extruding after broken
Compositions raw material is crushed after being dried in vacuo, i.e. acquisition grain compositions；
(5), fruit composition prepare, fruit composition raw material is cleaned, shortening, the fruit composition raw material after shortening into
It is crushed after row vacuum drying, i.e. acquisition fruit composition；
(6), prepared by nut composition, and nut composition material is cleaned, and the mushroom composition material after drying carries out true
It is crushed after sky is dry, i.e. acquisition mushroom composition；
(7), aquatic class composition preparation, aquatic class composition material is cleaned, shortening, the aquatic class composition after shortening
Raw material is crushed after being dried in vacuo, that is, obtains aquatic class composition；
(8), mushroom composition prepare, mushroom composition material is cleaned, shortening, the mushroom composition material after shortening into
It is crushed after row vacuum drying, i.e. acquisition mushroom composition；
(9), meat, eggs and milk class composition material is carried out shortening by meat, eggs and milk class composition, and the animal protein compound after shortening is former
Material is crushed after being dried in vacuo, i.e. acquisition meat, eggs and milk class composition；
(10), finished product is mixed, each composition that step (2) ~ (9) obtain proportionally is mixed, after mixing, that is, is made
Obtain finished product；
(11), it packs, finished product is subjected to sub-material packaging, finally obtains product.
The present invention has the advantage that
The advantages that nutrition is balanced, safe and reliable and easy to use is a kind of satisfactory anti-aging, preventing tumor, promotes growth
The health food of development.
Specific embodiment
Technical solution of the present invention is described in detail below by specific embodiment, but the scope of the present invention
It is not limited by following example.
Embodiment one
A kind of nutritional health food is combined by vegetable composition, tubers composition, grain compositions, fruit composition, nut
Eight kinds of object, aquatic class composition, mushroom composition and meat, eggs and milk class composition compositions mix；
Wherein weight percent shared by each composition is respectively as follows:
Vegetable composition 27.9%；
Tubers composition 20.3%；
Grain compositions 16.7%；
Fruit composition 12.4%；
Nut composition 8.1%；
Aquatic class composition 7.3%；
Mushroom composition； 3.5%
Meat, eggs and milk class composition 3.8%.
Further, wherein the vegetable composition is by rape, spinach, cauliflower, green asparagus, wax gourd, pumpkin, cucumber, eggplant
Son, tomato, one of or plurality of raw materials composition；
Wherein each weight of material number is respectively as follows: 3.5 parts of rape, 2.8 parts of spinach, 3.4 parts of cauliflower, 2.8 parts of green asparagus, wax gourd
3.3 parts, 3.2 parts of pumpkin, 2.7 parts of cucumber, 3.2 parts of eggplant, 3 parts of tomato.
The tubers composition by Chinese yam, sweet potato, potato, taro, carrot, white radishes, one of or a variety of originals
Material composition；
Wherein each weight of material number is respectively as follows: 2.6 parts of Chinese yam, 2.4 parts of sweet potato, 4.6 parts of potato, 4.5 parts of taro, carrot
3.3 parts, 2.9 parts of white radishes.
The grain compositions are by highland barley, millet, black rice, Semen Coicis, wheat, red bean, mung bean, semen viciae fabae, tartary buckwheat, height
Fine strain of millet, white peas or beans, soya bean, semen sojae atricolor, green soya bean, oat, one of or plurality of raw materials composition；
Wherein 0.2 part of highland barley, 0.8 part of millet, 0.4 part of black rice, 1.1 parts of Semen Coicis, 0.7 part of wheat, 1.2 parts of red bean, mung bean 0.9
Part, 1.3 parts of semen viciae fabae, 1.4 parts of tartary buckwheat, 1.6 parts of sorghum, 0.9 part of white peas or beans, 1.7 parts of soya bean, 1.3 parts of semen sojae atricolor, 1.9 parts of green soya bean, swallow
1.3 parts of wheat.
The fruit composition by yellow peach, apple, grape, banana, hawthorn, jujube, one of or plurality of raw materials form；
Wherein each weight of material number is respectively as follows: 1.1 parts of yellow peach, 1.7 parts of apple, 2.7 parts of grape, 2.8 parts of banana, hawthorn 3.2
Part, 0.9 part of jujube.
The nut composition by walnut kernel, Semen sesami nigrum, sunflower seeds, peanut, SEMEN PINI KORAIENSIS, Chinese chestnut, one of or it is a variety of
Raw material composition；
Wherein each weight of material number is respectively as follows: 1.2 parts of walnut kernel, 0.7 part of Semen sesami nigrum, 1.4 parts of sunflower seeds, 1.5 parts of peanut, pine
1.8 parts of sub- benevolence, 1.5 parts of Chinese chestnut.
The aquatic class composition by sea cucumber, Gorgon fruit, water caltrop kernel, lotus rhizome, one of or plurality of raw materials form；
Wherein each weight of material number is respectively as follows: 0.4 part of sea cucumber, 2.1 parts of Gorgon fruit, 1.7 parts of water caltrop kernel, 3.1 parts of lotus rhizome.
The mushroom composition by needle mushroom, mushroom, dried mushroom, black fungus, tremella, one of or plurality of raw materials form；
Wherein each weight of material number is respectively as follows: 0.9 part of needle mushroom, 0.7 part of mushroom, 0.5 part of dried mushroom, 0.8 part of black fungus, tremella
0.6 part.
The meat, eggs and milk class composition by beef, mutton, egg, donkey milk powder, one of or plurality of raw materials form；
Wherein each weight of material number is respectively as follows: 1.2 parts of beef, 1.1 parts of mutton, 1.1 parts of egg, 0.4 part of donkey milk powder.
The invention also discloses a kind of preparation methods of nutrient and healthcare products, include the following steps:
(1), weighing；Proportionally weigh vegetable composition, tubers composition, grain compositions, fruit composition, nut group
Object, aquatic class composition, mushroom composition and meat, eggs and milk class composition material are closed as raw material for standby；
(2), vegetable composition prepare, vegetable combination raw material is cleaned, quick-boil scald obtain it is cooked, by cooked vegetables group
It closes and carries out broken acquisition vegetable composition after raw material is dried in vacuo；
(3), tubers composition prepare, tubers composition material is cleaned, quick-boil scald obtain it is cooked, by cooked
Stem class composition material carries out broken acquisition tubers composition after being dried in vacuo；
(4), prepared by grain compositions, and grain compositions raw material is cleaned, and carries out high temperature puffing, the paddy after extruding after broken
Compositions raw material is crushed after being dried in vacuo, i.e. acquisition grain compositions；
(5), fruit composition prepare, fruit composition raw material is cleaned, shortening, the fruit composition raw material after shortening into
It is crushed after row vacuum drying, i.e. acquisition fruit composition；
(6), prepared by nut composition, and nut composition material is cleaned, and the mushroom composition material after drying carries out true
It is crushed after sky is dry, i.e. acquisition mushroom composition；
(7), aquatic class composition preparation, aquatic class composition material is cleaned, shortening, the aquatic class composition after shortening
Raw material is crushed after being dried in vacuo, that is, obtains aquatic class composition；
(8), mushroom composition prepare, mushroom composition material is cleaned, shortening, the mushroom composition material after shortening into
It is crushed after row vacuum drying, i.e. acquisition mushroom composition；
(9), meat, eggs and milk class composition material is carried out shortening by meat, eggs and milk class composition, and the animal protein compound after shortening is former
Material is crushed after being dried in vacuo, i.e. acquisition meat, eggs and milk class composition；
(10), finished product is mixed, each composition that step (2) ~ (9) obtain proportionally is mixed, after mixing, that is, is made
Obtain finished product；
(11), it packs, finished product is subjected to sub-material packaging, finally obtains product.
By to the final products obtained of embodiment one, carry out data analyze to obtain antioxidant it is as follows:
The foundation of the subacute mice aging model induced by D- galactolipin is to comment the anti-aging effects of embodiment one
Estimate.
D- galactolipin 1000mg/kg weight is subcutaneously injected in the nape of the neck daily after male mouse of kunming adaptable fed 1 week,
Experimental endpoints survey mice serum superoxide dismutase (Superoxide Dismutase, SOD), malonaldehyde
(Malondialdehyde, MDA) content.Substantially less than normal mouse and with it is apathetic, be slow in action, failure of memory,
As modeling success.
Experimental group
By mice group blank control group, aging model group, one intervention group of aging embodiment:
Blank control group (SD+NS): male mouse of kunming is isometric in the nape of the neck subcutaneous injection daily after being fed with chow diet 1 week
Physiological saline.
Aging model group (SD+D-gala): male mouse of kunming is subcutaneously infused in the nape of the neck daily after being fed with chow diet 1 week
Penetrate D- galactolipin 1000mg/kg weight.
One group of embodiment (WS+D-gala): male mouse of kunming is subcutaneously infused in the nape of the neck daily after being fed with chow diet 1 week
D- galactolipin 1000mg/kg weight is penetrated, and starts to feed one food intervention of embodiment in 4th week.
After Experiment intervention 12 weeks, mouse is put to death, detects related experiment index.
Collection of specimens
Take blood: eyeball or heart extracting blood, blood stand 30min, are centrifuged 15min at 4 DEG C with 3000 rpm/min, conventional to separate
Serum takes upper serum to put -80 DEG C of refrigerator cold-storages spare.
It takes tissue: taking out the histoorgans such as thymus gland, spleen, brain, liver on ice bag rapidly, with ice normal saline flushing, inhale
Blood is removed, fat, mesentery is repaired with filter paper suck dry moisture and claims its weight in wet base with electronic balance；Physiological saline is added, is made 10%
Tissue homogenate, be centrifuged 15min at 4 DEG C with 3000 rpm/min, take supernatant to set refrigeration in refrigerator spare.
Observation index:
The conventional indexs such as activity, hair, appetite, weight
Nude mice weight is measured weekly, is calculated appetite, is observed and recorded each group activity and hair situation
Memory function detection-Morris water maze
Water maze is divided into 4 subregions, the place of entry of east, south, west, north four is indicated on each subregion wall.Have one above labyrinth
Video camera is connected to a computer, and carries out all-the-way tracking to experiment mice activity using computer software and shoots with video-corder, can show
Entire activity trajectory, time needed for record mouse finds platform indicate the ability of learning and memory of mouse.Daily by animal head court
Pool wall is respectively put into pond by the place of entry of east, south, west, north 4, and platform is placed in the center of a certain subregion, experimentation station
Platform position remains unchanged.Computer system automatically records mouse from place of entry in-track platform required time and shoots with video-corder during this period of time
Swimming distance, found the time required to platform using mouse as learning and memory achievement.If mouse is not found within the set time
Platform, computer stop tracking, and experiment is limited every time with 120 s.If mouse finds station in 120 s of limit time in training
Platform allows mouse to stop 20 s on platform, if mouse does not find platform, mouse is placed on platform and stops 20 by experimenter
s.It is taken down from platform after 20 s, starts again at training after 1 min that rests.General intact animal is through 5 ~ 6 training Days
It can learn the correct position that platform is found with most fast, optimal track.
The detection of hippocampus immunohistochemistry
Hippocampus be responsible for memory storage conversion and orientation etc. functions, experimental endpoints we will remove the hippocampal tissue of mouse.
1. comparing the size of two groups of hippocampus
2. being changed by the general form that HE dyes observation CA 1 Zone of Hippocampus in Mouse nerve cell；
3. by immunohistochemistry (immunohistochemistry, IH) dyeing observation hippocampus of mice A β deposition and
The expression of the area CA1 GFAP, VEGF change.
Other indexs (general nutrition condition) of body:
Detect serum albumin levels and hindlimb muscle (flesh encloses, flesh weight).
Immune cell function detection
Materials: spleen, lymph node, peripheral blood, its hetero-organization etc..
Method: flow cytometer (fluorescence multi-color marking)；Multi-color marking tissue in situ analyzes (TSA), ELISA, Q-PCR.
Testing index:
Associated immune cells hypotype and inflammation index are detected by flow cytometer, Elisa kit etc..
Oxidation resistance
Detection method: Elisa kit
Testing index: SOD, MDA in serum and liver, glutathione peroxidase (Glutathione Peroxidase,
GSH-Px) etc..
Experimental result
Ordinary circumstance
To experimental endpoints, compared with the control group, being slow in action occurs in one group of mouse of model group and embodiment, drowsiness, spiritual withers
Equal agings sign is wasted, but one group of mouse of embodiment is significantly better than model group.
Three groups of mouse weight differences it is statistically significant (F=21.876,P< 0.001), model group mouse body weight is significantly lower than
Control group and WS group (P=0.001,P< 0.001), and one group of mouse weight of embodiment is even higher than control group (P=0.006).
One group of mouse appetite of embodiment is totally in rising trend.Compared with the control group, model group mouse appetite is substantially reduced.
The results of analysis of variance shows, three groups of mice serum albumin difference it is statistically significant (F=14.753, P <
0.001).Compared with the control group, model group Mouse albumin level is substantially reduced (P < 0.001), and one group of difference of embodiment without
Statistical significance, and one group of Mouse albumin of embodiment is apparently higher than model group (P < 0.001).
The results of analysis of variance shows, three groups of mouse hind leg fleshes enclose and and the method for double differences it is not statistically significant (F enclose=19.041, P <
0.001；Weight=13.498, P < 0.001 F).
The group the experimental results showed that, embodiment one can significantly improve the senile symptom of exhausted mining areas, and can
Mouse weight and albumin level are increased, implies that embodiment one can improve the general nutrition condition of mouse, and there is centainly anti-ageing
Old effect.
The influence of embodiment a pair of learning and memory of little mouse function
One-way analysis of variance is the results show that three groups of escape latency difference are statistically significant.Compared with the control group, model group
Mouse escape latency obviously increases (P=0.006), but not statistically significant with one group of mouse escape latency difference of embodiment.
Compared with model group, (P=0.02) is obviously reduced in one group of mouse escape latency of embodiment, this result shows that, one energy of embodiment
Enough improve the ability of learning and memory of exhausted mining areas.
HE dyeing is carried out it was found that relative to control group mice to brain tissue Hippocampal CA 1, model group mouse cone is thin
There is different degrees of reduction, born of the same parents' nuclear hyperchromatism, pyknosis in born of the same parents' number of plies, and kernel is unobvious, cytoplasm is rare, and one group of embodiment is dragged
The body cell number of plies is also reduced, but there is born of the same parents' nuclear hyperchromatism, the cell of pyknosis is significantly reduced compared with model group.This result table
Bright, embodiment one can improve Mice brain tissues aging relevant form, delay senescence.
We have detected the variation of brain tissue A β, VEGF and GFAP by immunohistochemical staining.As a result, it has been found that comparing
Significantly raised in the expression of control group, model group Mice brain tissues A β and Hippocampal CA 1 GFAP, vegf expression is horizontal significant
It reduces, and embodiment one is able to suppress this ageing process of D-gala induction.This result shows that, embodiment one can delay
The subacute aging model Mice brain tissues senescence progress of D-gala induction, anti-aging effects are significant.
The influence of the organ indexs such as embodiment a pair of mouse brain, thymus gland, spleen and liver
To experimental endpoints, brain, thymus gland, spleen and liver are taken, detects mice organs index.One-way analysis of variance the results show that
Each group mouse brain index differential is statistically significant (F=9.487, P < 0.001), compared with the control group, model group and embodiment one
Group mouse cerebral index significantly reduces (P < 0.001), and one group of mouse of embodiment is averaged cerebral index higher than model group, but difference is without statistics
Learn meaning.Similarly, each group mouse thymus index differential is significant (F=4.939, P=0.015), and compared with the control group, model group is small
Mouse thymus index is substantially reduced (P=0.005), and model group mouse thymus index is significantly less than WS group mouse (P=0.032).
And index and spleen index and the not statistically significant (F of liver index differencespleen=0.421, Fhepatic=0.531).
Embodiment a pair is related oxidized, Antioxidant Indexes influences
We have detected serum, MDA content and SOD, GSH-Px activity in brain and liver.As a result, it has been found that with corresponding control group phase
Than the MDA content in model group and embodiment one group of mice serum, brain tissue and liver obviously increases, SOD and GSH-Px water
Flat to be substantially reduced, this is the result shows that subacute aging model is successfully established.Compared with model group, one group of mice serum of embodiment
And brain tissue MDA level is substantially reduced, serum and liver SOD activity are significantly raised, and liver GSH-Px activity is significantly raised.
The group the experimental results showed that, D-gala induction subacute aging Establishment of mouse model success.In aging course,
Embodiment one can adjust related oxidized stress level in different tissues, and protective tissue is from oxidativestress damage, to delay
Ageing process.
Immunocyte subgroup and cell factor in spleen
As the result is shown: WS can protect the CD3 of D-gala/SD processing induction+CD8+The drop of T cell, NK cell proportion and quantity
It is low；Reduce the ratio and quantity (no difference of science of statistics) of the IL-10 secretory cell of D-gala/SD processing induction；But to CD3+CD4+
T cell, Ly6G+Granulocyte, CD19+The percentage of B cell and regulatory T cells has no significant effect.
Inflammation index is horizontal in serum
Using TNF-α in ELISA (R&D company) detection serum, the content of IL-10 and TGF-β.The results show that after WS processing,
It is able to suppress the secretion for handling the IL-10 cell factor of induction by D-gala/SD, but the secretion of TNF-α, TGF-β is not shown
Writing influences.
Preliminary conclusion: WS processing can be protected significantly by lethal thin in D-gala/SD inducing mouse aging model spleen
Born of the same parents' subgroup (CD3+CD8+T cell, NK cell) quantity and ratio reduction；Inhibit spleen to generate the cell proportion of IL-10 and subtracts
The content of few serum IL -10.It but include CD4 to other cell subsets+T cell, granulocyte, B cell and regulatory T cells
Quantity and ratio have no significant effect.
Aging is physiology sexuality caused by the factors such as environment and genetics, this process can cause a variety of disease incidences and dead
Die the soaring of rate.Current many foods and drug are found to have good delaying senility function, and researcher actively visits
The effective active composition sought these foods, play anti-aging effects in drug, it has been found that active material pass through reduction oxygen mostly
Change stress damage, suppression inflammation and adjusts immune etc. play a role.Embodiment first is that a kind of 55 kinds of high-quality food materials of set through special
The functional food that technique is extracted, by lab analysis it was found that many active constituents in embodiment one can pass through oxidation
Stress-inflammation-is immune etc., and approach delay senescence to a certain extent
It is well known that the decline of memory function is the characteristic feature of aging.This experiment finds embodiment one in addition to that can improve model
The general state of mouse, moreover it is possible to significantly improve mouse memory power.Since memory function is closely related with cerebral hippocampus, we are detected
The expression of mouse A β, GFAP and VEGF.As a result, it has been found that embodiment one can reduce the area exhausted mining areas cerebral hippocampal CA1
A β deposition and GFAP are horizontal, and significantly rise high vegf expression level, this is the result shows that embodiment one can improve mouse aging
Cognition and learning functionality, have significant anti-aging effects.
The effect of this research mainly inquires into embodiment a pair of mouse aging from anti-oxidant, suppression is scorching, adjusts immune and memory etc..
Our result of study shows: embodiment a pair of d-galactolipin induction mouse subacute aging model has obvious anti-aging
Effect, embodiment one have the protection of apparent learning and memory, anti-oxidant, anti-inflammatory and enhancing immunization.In conclusion embodiment
One has many advantages, such as that nutrition is balanced, safe and reliable and easy to use, is a kind of satisfactory Amti-sanility health-care food.
Claims (10)
1. a kind of nutritional health food, it is characterised in that by vegetable composition, tubers composition, grain compositions, fruit group
Eight kinds of object, nut composition, aquatic class composition, mushroom composition and meat, eggs and milk class composition compositions are closed to mix；
Wherein weight percent shared by each composition is respectively as follows:
Vegetable composition 27 ~ 29%；
Tubers composition 19 ~ 21%；
Grain compositions 16 ~ 18%；
Fruit composition 11 ~ 13%；
Nut composition 7 ~ 9%；
Aquatic class composition 6 ~ 8%；
Mushroom composition； 3~4%
Meat, eggs and milk class composition 3 ~ 4%.
2. a kind of nutrient and healthcare products according to claim 1, it is characterised in that: the vegetable composition by rape, spinach,
One of cauliflower, green asparagus, wax gourd, pumpkin, cucumber, eggplant, tomato or plurality of raw materials composition；
Wherein each weight of material number is respectively as follows: 0 ~ 3.5 part of rape, 0 ~ 2.8 part of spinach, 0 ~ 3.4 part of cauliflower, green asparagus 0 ~ 2.8
Part, 0 ~ 3.3 part of wax gourd, 0 ~ 3.2 part of pumpkin, 0 ~ 2.7 part of cucumber, 0 ~ 3.2 part of eggplant, 0 ~ 3 part of tomato.
3. a kind of nutrient and healthcare products according to claim 1, it is characterised in that: the tubers composition is by Chinese yam, red
Potato, potato, taro, carrot, white radishes, one of or plurality of raw materials composition；
Wherein each weight of material number be respectively as follows: 0 ~ 2.6 part of Chinese yam, 0 ~ 2.4 part of sweet potato, 0 ~ 4.6 part of potato, 0 ~ 4.5 part of taro,
0 ~ 3.3 part of carrot, 0 ~ 2.9 part of white radishes.
4. a kind of nutrient and healthcare products according to claim 1, it is characterised in that: the grain compositions by highland barley, millet,
Black rice, Semen Coicis, wheat, red bean, mung bean, semen viciae fabae, tartary buckwheat, sorghum, white peas or beans, soya bean, semen sojae atricolor, green soya bean, oat, one of
Or plurality of raw materials composition；
Wherein 0 ~ 0.2 part of highland barley, 0 ~ 0.8 part of millet, 0 ~ 0.4 part of black rice, 0 ~ 1.1 part of Semen Coicis, 0 ~ 0.7 part of wheat, red bean 0 ~
1.2 part, 0 ~ 0.9 part of mung bean, 0 ~ 1.3 part of semen viciae fabae, 0 ~ 1.4 part of tartary buckwheat, 0 ~ 1.6 part of sorghum, 0 ~ 0.9 part of white peas or beans, soya bean 0 ~ 1.7
Part, 0 ~ 1.3 part of semen sojae atricolor, 0 ~ 1.9 part of green soya bean, 0 ~ 1.3 part of oat.
5. a kind of nutrient and healthcare products according to claim 1, it is characterised in that: the fruit composition by yellow peach, apple,
Grape, banana, hawthorn, jujube, one of or plurality of raw materials composition；
Wherein each weight of material number be respectively as follows: 0 ~ 1.1 part of yellow peach, 0 ~ 1.7 part of apple, 0 ~ 2.7 part of grape, 0 ~ 2.8 part of banana,
0 ~ 3.2 part of hawthorn, 0 ~ 0.9 part of jujube.
6. a kind of nutrient and healthcare products according to claim 1, it is characterised in that: the nut composition is by walnut kernel, black
Sesame, sunflower seeds, peanut, SEMEN PINI KORAIENSIS, Chinese chestnut, one of or plurality of raw materials composition；
Wherein each weight of material number be respectively as follows: 0 ~ 1.2 part of walnut kernel, 0 ~ 0.7 part of Semen sesami nigrum, 0 ~ 1.4 part of sunflower seeds, peanut 0 ~
1.5 parts, 0 ~ 1.8 part of SEMEN PINI KORAIENSIS, 0 ~ 1.5 part of Chinese chestnut.
7. a kind of nutrient and healthcare products according to claim 1, it is characterised in that: the aquatic class composition is by sea cucumber, Gorgon euryale
Reality, water caltrop kernel, lotus rhizome, one of or plurality of raw materials composition；
Wherein each weight of material number is respectively as follows: 0 ~ 0.4 part of sea cucumber, 0 ~ 2.1 part of Gorgon fruit, 0 ~ 1.7 part of water caltrop kernel, lotus rhizome 0 ~ 3.1
Part.
8. a kind of nutrient and healthcare products according to claim 1, it is characterised in that: the mushroom composition is by needle mushroom, perfume (or spice)
Mushroom, dried mushroom, black fungus, tremella, one of or plurality of raw materials composition；
Wherein each weight of material number be respectively as follows: 0 ~ 0.9 part of needle mushroom, 0 ~ 0.7 part of mushroom, 0 ~ 0.5 part of dried mushroom, black fungus 0 ~
0.8 part, 0 ~ 0.6 part of tremella.
9. a kind of nutrient and healthcare products according to claim 1, it is characterised in that: the meat, eggs and milk class composition by beef,
Mutton, egg, donkey milk powder, one of or plurality of raw materials composition；
Wherein each weight of material number is respectively as follows: 0 ~ 1.2 part of beef, 0 ~ 1.1 part of mutton, 0 ~ 1.1 part of egg, donkey milk powder 0 ~ 0.4
Part.
10. a kind of preparation method of nutrient and healthcare products as described in claim 1, it is characterised in that include the following steps:
(1), weighing；Proportionally weigh vegetable composition, tubers composition, grain compositions, fruit composition, nut group
Object, aquatic class composition, mushroom composition and meat, eggs and milk class composition material are closed as raw material for standby；
(2), vegetable composition prepare, vegetable combination raw material is cleaned, quick-boil scald obtain it is cooked, by cooked vegetables group
It closes and carries out broken acquisition vegetable composition after raw material is dried in vacuo；
(3), tubers composition prepare, tubers composition material is cleaned, quick-boil scald obtain it is cooked, by cooked
Stem class composition material carries out broken acquisition tubers composition after being dried in vacuo；
(4), prepared by grain compositions, and grain compositions raw material is cleaned, and carries out high temperature puffing, the paddy after extruding after broken
Compositions raw material is crushed after being dried in vacuo, i.e. acquisition grain compositions；
(5), fruit composition prepare, fruit composition raw material is cleaned, shortening, the fruit composition raw material after shortening into
It is crushed after row vacuum drying, i.e. acquisition fruit composition；
(6), prepared by nut composition, and nut composition material is cleaned, and the mushroom composition material after drying carries out true
It is crushed after sky is dry, i.e. acquisition mushroom composition；
(7), aquatic class composition preparation, aquatic class composition material is cleaned, shortening, the aquatic class composition after shortening
Raw material is crushed after being dried in vacuo, that is, obtains aquatic class composition；
(8), mushroom composition prepare, mushroom composition material is cleaned, shortening, the mushroom composition material after shortening into
It is crushed after row vacuum drying, i.e. acquisition mushroom composition；
(9), meat, eggs and milk class composition material is carried out shortening by meat, eggs and milk class composition, and the animal protein compound after shortening is former
Material is crushed after being dried in vacuo, i.e. acquisition meat, eggs and milk class composition；
(10), finished product is mixed, each composition that step (2) ~ (9) obtain proportionally is mixed, after mixing, that is, is made
Obtain finished product；
(11), it packs, finished product is subjected to sub-material packaging, finally obtains product.
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| CN111387496A (en) * | 2020-04-17 | 2020-07-10 | 烟台五神生物科技有限公司 | Health food for improving immunity of colon cancer patients |
| CN111406943A (en) * | 2020-05-12 | 2020-07-14 | 烟台五神生物科技有限公司 | A health food for improving nutrition status |
| CN111418839A (en) * | 2020-05-12 | 2020-07-17 | 烟台五神生物科技有限公司 | Health food for improving intestinal flora and metabolism |
| CN111418840A (en) * | 2020-05-12 | 2020-07-17 | 烟台五神生物科技有限公司 | Health food for preventing and treating sarcopenia |
| CN111480829A (en) * | 2020-05-12 | 2020-08-04 | 烟台五神生物科技有限公司 | Health product for enhancing immunity |
| CN111557437A (en) * | 2020-05-12 | 2020-08-21 | 烟台五神生物科技有限公司 | Health food for preventing and treating senile dementia |
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