CN1097598A - Vitamin micro-element purine pyrimidine dinucleotide nutrient product and manufacture method - Google Patents

Abstract

A kind of vitamin micro-element purine pyrimidine dinucleotide nutrient product and manufacture method, be characterized in providing any purine nucleotides and any pyrimidine nucleotide to satisfy the human body nucleic acid to the raw-material needs of nucleotide, and provide closely related simultaneously and vitamin and trace element that human body easily lacks improve nucleic acid metabolism with nucleic acid.Can be respectively applied for the production of high grade nucleotide food, beverage (containing baby-children product), flavoring agent, medicine, edible cosmetics etc., given full play to the effect of nucleic acid health care, and the potentiality of the interior nucleic acid of body, solve pharmacy industry and food drink cosmetics industry etc. and striven the contradiction of nucleotide raw material, technology is simple, the product super quality and competitive price, easy large-scale industrial production satisfies people and is health care and the disease preventing and treating growing demand to nucleic acid product.

Description

Vitamin micro-element purine pyrimidine dinucleotide nutrient product and manufacture method

The present invention relates to nucleotide is that raw material carries out method for processing.

The nucleic acid molecules chain is made up of purine nucleotides and pyrimidine nucleotide, and therefore in the nucleic acid building-up process, purine class nucleotide and miazines nucleotide have function of equal importance, and Neither of the two can be dispensed.Nucleic acid is to constitute most important component in the human body cell, is nuclear core substance, and it not only provides cytogenetics information, and is the basis of protein synthesis, is the essence of life.

Academia does not take much count of the health-care effect of supplemented with exogenous nucleic acid always before the sixties, think that nucleic acid not necessarily needs to replenish from external, because human body self can synthesizing ribonucleotide, ignored because of human senility, baby children liver is grown the pregnant parent nucleus acid of immaturity demand greatly to satisfy the ability drop that factors such as fetus supply and liver disease cause the liver nucleic acid, have a strong impact on the human body normal physiological function and be difficult to reverse etc. has a strong impact on healthy factor, even cause multiple disease that is difficult to cure such as hereditary information change to cause cancer, the facts such as senilism, and more emphasis is that the seasoning of single nucleotide increases bright effect as guanyl, inosinic acid or nucleotide derivative are used for the treatment of the effect of certain disease as treatment liver disease, heart disease, ophthalmic, the inosine of hematologic disease (inosine), the 5-fluorine urine pyridine pyridine of treatment cancer, the vidarabine of treatment viral disease, cytosine arabinoside, medicine adenosine triphosphate etc. is regulated in ribavirin and energy metabolism, yet these all can not provide nucleic acid to need the primary condition of purine and pyrimidine nucleotide simultaneously, can not satisfy from measuring, the good health care effect so be far from being, and the use of ucleotides medicine is general all after suffering from above-mentioned various serious disease, control principle against anti-overweighting, under a lot of situations or even " mend the fold after the sheep is lost and come too late ", the incurable disease that formation should not take place.Fact proved: replenish nucleic acid and can prevent effectively that cancer from taking place before cancer takes place, restock nucleic acid is to reversing the then invalid or DeGrain of cancer after having caused cancer under the situation of long-term lacking nucleic acid.Because the nucleic acid chains of having damaged can not in time be repaired because of nucleotide lacks, as easy as rolling off a logly cause permanent damage and genetic code is changed, or the breach that forms of damage for want of nucleotide fill up and can not heal rapidly, induce viral nucleic acid to be incorporated into the reasons such as a part that form human body chromosome nucleic acid on the human body nucleic acid chains, cause hereditary information to change, and hereditary information is once change and just to be difficult to reverse, thus the serious harm health.This importance of health-care effect that just proves absolutely nucleic acid is greater than therapeutical effect, and effect just is ideal much than single therapy certainly, be to prevent, control double effects, and anti-prior to control, anti-overweighting control, prevent trouble before it happens.

The Chinese invention patent application number is 91107201X, publication number is CN1066568A, the application for a patent for invention of " products of fully nutrient vegetables and manufacture method " by name is according to above-mentioned the principles of science, emphasis is conceived to introduce the deficiency that exogenous nucleic acid replenishes human body nucleic acid from the food angle, the health care and the therapeutical effect of nucleic acid brought into play in the measure of relying mainly on prevention, nucleic acid in the vegetable of employing high-nucleic acid yeast (nucleic acid content is up to more than 13%) and high-density cells structure provides purine pyrimidine nucleotide to remedy the deficiency of nucleic acid in vivo synchronously, and solved the nucleic acid source deficiency problem that costs an arm and a leg, also solved simultaneously baby children and all and eaten the difficult problem etc. of the difficult environment of dish edible fresh vegetable down, by the authoritative magazine Britain WPI(in world world patents index) include.But this application fails to solve the problem that the nucleic acid poorly water-soluble is unfavorable for developing liquid beverage and medicine, cosmetics etc., the rational proportion of also failing to solve various nucleotide in the human body is to improve the nucleic acid physiology problem of tiring, be used for flavoring agent and increase bright effect also undesirable (significantly increasing bright effect) because of nucleotide just has, and nucleic acid must could absorb after small intestinal is digested to nucleotide and nucleoside earlier, so the nucleotide of absorption and nucleoside amount are often less than the content of food amplifying nucleic acid.

The Chinese invention patent application number is 931109256, publication number is CN1077689A, the application for a patent for invention of " polynucleotide nutrient product and manufacture method " by name, overcome the weak point of above-mentioned patent application preferably, and utilized plant pollen particularly china natural resources Pollen Maydis very abundant and that fail so far to large-scale develop and utilize replenish DNA and Deoxydization nucleotide, not only replenish purine, pyrimidine nucleotide simultaneously but also make the utilization of body inner nucleotide more become reasonably economical.Owing to solved water solublity and micromolecule problem, make its purposes expand to numerous areas such as infant and child food (replenish deficiency of Lac Bovis seu Bubali nucleotide and strengthen the ability of the young resist the disease of baby), beverage, flavoring agent, medicine, cosmetics from single food.But this application fails to consider that the production of pure property medicine for treatment product and food are drunk, cosmetics industry is striven certain or certain several single nucleotide raw material problem, and because medicine is often drunk than eating, cosmetics are more important also more costly to the people, so cause at first by pharmacy industry with preferential required nucleotide kind of acquisition of high price and quantity after, industry etc. is drunk in remaining just handling at a low price to the low food of price, causes the prescription and the effect of this application design to can not get abundant guarantee in actual applications.

Continuous appearance and nucleic acid class food drink along with production-scale continuous expansion of nucleic acid quasi drugs and new medicine, the continuous expansion of cosmetics industry and other nucleic acid based article industry and emerging, these contradictions will be more and more outstanding, even mutual restriction developing steps, should on science and technology, seek countermeasure early, make they can each takes what he needs synchronized development, do not fight for raw material and assurance curative effect and health-care effect separately mutually, be aided with simultaneously and play an important role in nucleic acid in vivo utilization and the building-up process and multivitamin and trace element that human body also easily lacks, make nucleic acid bring into play perfect effect in vivo, thereby increase substantially the biological value of nucleic acid, the nucleic acid resource of saves valuable, be beneficial to the reduction product cost, make science and technology work for Gospel for more people.

Purpose of the present invention provides a kind of vitamin micro-element purine pyrimidine dinucleotide nutrient product and manufacture method for the deficiency that solves prior art exactly, and the scientific and technological principle of its foundation is as follows:

The route of synthesis of purine nucleotides at first is synthetic inosine monophosphate, IMP IMP(inosinic acid in the body), be transformed into adenylic acid AMP and guanylic acid GMP again, guanylic acid and adenylic acid can be transformed into inosine monophosphate, IMP by deaminizating again under deaminase catalysis, the generation of deoxidation purine nucleotides also is the form with nucleoside or nucleotide, particularly the form reduction with nucleoside diphosphate produces, that is purine class nucleotide is interconvertible, and guanylic acid can suppress the transformation of hypoxanthine to xanthylic acid (XMP), that is inhibition generates guanylic acid self, adenylic acid then suppresses the transformation of inosine monophosphate, IMP to the adenosine succinic acid, that is inhibition generates adenylic acid self, so when AMP or GMP generate when too much, this feedback regulation just can stop the generation of AMP or GMP automatically, that is the purine nucleotides kind and the quantity conversion of inducing IMP in body, to be lacked automatically, thereby reach poised state; Mechanism is opposite with suppressing, XMP generates GMP needs ATP to participate in, so can quickening GMP, excessive ATP generates, excessive GTP quickens IMP and changes AMPS(adenosine succinic acid into), so promote AMP to generate, because body can reach poised state, the purine nucleotides that body lacked so synthetic promotion approach can be guaranteed supply equally according to the growing amount that needed nucleotide kind and quantity are regulated ATP or GTP automatically.Hence one can see that, needs only and replenish any purine nucleotides in the donor, just can make each required purine nucleotides of body all reach poised state substantially by the synthetic inhibition feedback system that reaches of the promotion of body self.The route of synthesis of pyrimidine nucleotide at first is synthesizing uridine acid UMP in the body, then the energy-rich phosphate group of accepting ATP under phosphokinase catalysis generates UDP or UTP, UTP generates CTP through amination, discharge an energy-rich phosphate bond more successively and form GDP and GMP respectively, obtain cytidylic acid.Deoxyuridine acid and deoxycytidylic acid then by corresponding two or nucleoside triphosphate reduction generate, this generation with the deoxidation purine nucleotides is identical.Deoxythymidine acid then produces by methylating of uracil Deoxydization nucleotide, and UMP and CTP all suppress the carbamyl transferase active, thereby all suppresses the generation of UMP.Hence one can see that, although the synthesis mechanism of miazines nucleotide is than purine class nucleotide complexity, and product UMP and CTP all suppress the generation of UMP, but because uridylate is predecessor and the UMP and the CMP interconvertible equally (the CMP deamination generates UMP) of all pyrimidine nucleotides, therefore need only in body, replenish UMP or any pyrimidine nucleotide of CMP, just can reach the purpose of the various miazines nucleotide that additional body lacked simultaneously.This is identical with the principle effect of using a kind of purine class nucleotide just can obtain the various purine nucleotides that lack, and this is the important general character of purine, pyrimidine two big class nucleotide.Vitamin refers to keep that body health is necessary, can not synthesize in the body or synthetic insufficient, on physiological function neither constitute the primary raw material of various tissues, more not the source of energy i (in vivo), but one class low molecular compound of crucial effect is arranged regulating substance metabolism process.And during known many vitamin deficiency, substance metabolism generation obstacle.Because of the physiological function difference of various vitamin, different diseases then takes place so lack different vitamin, be referred to as disvitaminosis.The vitamin kind is a lot, and being easy to by food of having is additional, and what have is then opposite, causes human body very easily to lack.For improving the nucleic acid utilization rate, vitamin C, B that design adopts human body easily to lack and again nucleic acid metabolism is played an important role ₁₂And folic acid is tired with raising nucleic acid and the important physiological function of body series.Human body can not synthesize ascorbic acid owing to lack the enzyme event of synthetic vitamin C, so the people need be by food supply to ascorbic whole requirements.Because human body demand every day big (tens of milligram), even surpassing demand, picked-up also very easily directly discharges by urine with reduced form and dehydrogenation type, do not have in vivo obviously and store, and vitamin C is extremely unstable, Yi Weire, light, oxygen, bivalent metal ions etc. destroy, the very easily regular shortage of body, add the very extensive and important (antioxidation of ascorbic physiological action, detoxifcation, promote intestinal ferrum to absorb, cholesterol reducing, regulate neural activity and improve myocardial function etc.), it is synthetic to strengthen body self nucleic acid that particularly vitamin C promotion folic acid is transformed into the tetrahydrofolic acid that physiologically active is arranged, so first-selected vitamin C.Folic acid is participated in purine, synthesizing of pyrimidine, purine pyrimidine is the raw material of nucleic acid, nucleic acid then instructs proteinic biosynthesis, so the growth and the anacmesis of erythrocyte when lacking folic acid, cause megaloblastic anemia disease, consequence was even more serious when pregnant mother lacked, even premature labor or cause deformity youngster (Chinese invention patent application number 93110925.6, publication number CN1077689A, polynucleotide nutrient product and manufacture method), so FDA-FDA has announced the establish new regulations draft, suggestion is added folic acid in food that indicates " feeding in raw material " printed words and raw-food material, help reducing the sickness rate (People's Daily's on October 12nd, 1993) of baby's birth defect, visible folic acid is to safeguarding the importance of health, that is is one of nucleic acid health care meaning.Synthesize the insufficient while at supplemented with exogenous nucleic acid to remedy body nucleic acid, Supplement of folic acid is to give full play to the potentiality of body self nucleic acid, inside and outside take into account to improve the nucleic acid metabolism effect, reduce exogenesis nucleic acid magnitude of recruitment in a large number with the nucleic acid resource of saves valuable with reduce product cost.Folic acid is easily by photo damage, even room temperature is stored also very easily loss down, be not enough so only depend on food to replenish, though the human intestine antibacterial can be synthesized folic acid, but work as malabsorption, metabolism is not normal, organizes requirement to increase, and life-time service enteric antiseptics thing etc. all can cause folic acid deficiency, in fact absorb seldom, this has the special vitamin of critical function in nucleic acid so select folic acid for use, tires with enhanced products, is to have positive scientific meaning.Vitamin B ₁₂Participate in the metabolism of one carbon unit in the body, so it is that the utilization rate that potentiation promptly increases folic acid is strengthened nucleic acid and proteinic biosynthesis with the relation of folic acid, particularly supplies with the dUMP methyl and make it be transformed into dTMP to guarantee normally synthesizing of DNA.Its effect is the same with folic acid: promote erythrocytic growth and maturation.As the B that is deficient in vitamin ₁₂The time, show as the megaloblast pernicious anemia.Vitamin B ₁₂Also participate in the building-up process of choline etc., choline is used to constitute phospholipid, and the latter participates in lipoprotein at liver and forms, and is beneficial to and removes liver fat, the normal vitimin supplement B of hepatopath ₁₂Can prevent and treat fatty liver, so dimension B ₁₂Good health care and therapeutical effect are arranged.Because dimension B ₁₂It is all easily destroyed to meet strong acid and strong base, daylight, oxidant and Reducing agent, though the human intestine antibacterial can be synthesized dimension B ₁₂, but because this dimension B ₁₂Combine with protein and can not be absorbed by the body and (tie up B ₁₂Can only combine with the glycoprotein of excretory a kind of the crying of stomachus pyloricus mucosa " internal factor " and could see through intestinal wall and be absorbed, and not destroyed by intestinal bacteria), so select vitamin B for use ₁₂To strengthen the ability of body self nucleic acid.Although trace element content atomic (human total weight 5/10000ths) is very big to health effect, is the active center of many enzymes in the human body, hormone, vitamin, physiological function is extremely important.Found nearly 1000 kinds of enzymes in the human body, 70% needs trace element to activate, if trace element lacks in vivo or be out of proportion, will cause various physiological changies, then occurs various diseases clinically.Zinc is the necessary component of regulating the nucleic acid synzyme of dna replication dna, and zinc deficiency hinders nucleic acid and protein synthesis, thereby influences upgrowth and development of children, loss of appetite.Point out according to China Television Newspaper December in 1993 publication on the 28th " talking zinc and children's health again " literary composition: China child day zinc intake per capita only accounts for 49.1% of Chinese Soclety of Nutrition's recommendation, and child's zinc deficiency rate is 53.11%.The investigation in healthy newspaper nineteen ninety December report on the 13rd Zhejiang Province shows: to the survey showed that the general zinc deficiency of 666 healthy old mens in 1284 town and country different occupation, all do not reach standard, the rural area old man is more serious, causes immunologic hypofunction.Mend zinc sulfate after one month, T cell number, NK cytoactive, periphery lymphocyte number and PHA skin test all obviously improve.The effect this and more of zinc, as equal zinc deficiency such as diabetes, leukemia, vascular hypertension, zinc content also has rising during doing well,improving through treating after, even can reach normally.Because majority's zinc deficiency and zinc are to the facilitation of nucleic acid, first-selected trace element zinc.Selenium is the essential component of glutathione peroxidase; the latter's effect is the peroxide that decomposer hydrogen peroxide and unsaturated fatty acids acid oxidase produce; thereby prevent the destruction of its cell membrane system and keep protective effect; it is synthetic that selenium deficiency can influence antibody; selenium has therapeutical effect to the protein malnutrition child; organic mercury poisoning there is protective effect, some carcinogen is had resistant function.Selenium is subjected to people day by day to the important function of body and notes as selenium Keshan disease being had mitigation, and should be distributed widely in 14 provinces of China, district in the disease lesion.It has been established that, and human more than 40 kind of serious disease such as cancer, heart disease, diabetes are all relevant with scarce selenium, and World Health Organization's declaration in 1973: selenium is one of interior essential trace element of human body, has the important physical function.So select for use selenium to strengthen health-care effect.

Vitamin micro-element purine pyrimidine dinucleotide nutrient product provided by the invention is with purine class nucleotide AMP, GMP, IMP, Inosine(inosine) in any and miazines nucleotide UMP, CMP in any form dinucleotide source of various combination, folic acid, vitamin B by 1: 1 molecular number ₁₂, vitamin C, zinc sulfate (or GB2760-86 allows other zinc agent of using), sodium selenite (or selenic ester polysaccharide) make, its raw material consumption (by oven dry weight) is:

AMP 0-3.5 part GMP 0-3.6 part IMP 0-3.5 part

Imosyne 0-2.7 part

UMP 0-3.2 part CMP 0-3.2 part folic acid 0-0.1 part

Vitamin B ₁₂0-0.01 part vitamin C 0-0.5 part Monohydrated selenium dioxide

Sodium 0-0.01 part

Zinc sulfate (or other zinc agent of GB2760-86 permission use, with the conversion of the zinc content in zinc sulfate use amount) 0-0.2 part

Vitamin micro-element purine pyrimidine dinucleotide nutrient product and manufacture method are:

1, the purine pyrimidine dinucleotide manufacture method is:

In sterilizing room, press AMP3.5 part GMP3.6 part, IMP3.5 part, the oven dry weight of Inosine2.7 part appoint get a kind of, press UMP3.2 part, the oven dry weight of CMP3.2 part is appointed and is got a kind ofly, is added in the stainless steel equipment that has agitator, stirred 5-10 minute with 50-100 rev/min rotating speed, fully mixing is airtight standby.

2, compound vitamin and manufacture method are:

In sterilizing room, get 1 part in folic acid, vitamin B by oven dry weight ₁₂0.1 part, 5 parts of vitamin Cs, fully grinding well in the rustless steel mortar is last (2-4 minute), airtight preservation is standby.

3, compound microelement and manufacture method are:

In sterilizing room, get 0.1 part of the sodium selenite of oven dry weight, 2 parts in zinc sulfate (when using other zinc agent of GB2760-86, converting corresponding physiology share) with the zinc content in the zinc sulfate, in the rustless steel mortar, fully grind well into end (2-4 minute) standby.

4, the preparation of vitamin micro-element purine pyrimidine dinucleotide nutrient product:

In sterilizing room, with purine pyrimidine dinucleotide, compound microelement and compound vitamin, formula proportion weighing by different purposes products (as embodiment), in having the stainless steel equipment of agitator, stirred 5-10 minute with 200-400 rev/min rotating speed, fully mixing product.

The two thuja acid nutrient products of vitamin micro-element purine pyrimidine, the main nutrient composition (calculating by the over dry material) that contains in per 100 grams is:

Purine class nucleotide (AMP, GMP, IMP, Inosine any) 45 grams

Miazines nucleotide (UMP, CMP any) 44 grams

Folic acid 1.4 grams, vitamin C 6.6 grams, sodium selenite 0.14 gram

Vitamin B ₁₂0.14 gram, zinc sulfate 2.7 grams.

The purposes of vitamin micro-element purine pyrimidine dinucleotide nutrient product of the present invention is except that can be used as the nucleic acid host of producing nucleotide tablet, oral liquid, nutritional solution, also can be used as the nucleic acid additive of varieties of food items, beverage, flavoring agent, cosmetics, be made into height that series has a nucleic acid health care tire food, beverage, flavoring agent and cosmetics, consumption all can need by the GMP(ordinary production) the standard interpolation, as various beverages, sweet food, salty food, soup stock, soy sauce, vinegar, nucleic acid specially fresh health gourmet powder, cold cream, skin care liquid etc.

Vitamin micro-element purine pyrimidine dinucleotide nutrient product of the present invention and manufacture method have following advantage:

1, adopt the deficiency of nucleic acid in the nucleotide added body, not only available feeding form is replenished nucleic acid, improves its absorbance greatly, and it is most important that additional nucleic acid of non-feeding form such as cosmetics etc. are solved its absorbabilitys, saves a large amount of nucleic acid sources.Because nucleic acid molecule is hydrolyzed into nucleotide at digestive system small intestinal position by the nuclease of limited excretory nuclease of pancreas and mucous membrane of small intestine exfoliative cyte and nucleoside is digested and assimilated, this ability is very limited, causes the nucleic acid digestive utilization ratio not as directly replenishing the nucleotide height; For non-feeding forms such as cosmetics,, also can only supply with and just can receive corresponding health-care effect by the nucleotide (containing nucleoside) that Skin Cell directly absorbs because Skin Cell does not generally have the macromolecular ability of digestion.Thereby also driven the development of nucleic acid deep processing industries.

2, adopt any purine nucleotides and any pyrimidine nucleotide to satisfy the primary condition of nucleic acid simultaneously according to nucleotide change principle design in the nucleic acid metabolism approach in the human body, pharmacy industry and industry contention nucleotide kind and the high problems of cost such as food drink, cosmetics have not only been solved, and utilized the nucleic acid resource scientifically and rationally, neither cause the wasting of resources even throw aside useless and reasonable price, given full play in the body ability of self nucleic acid again, be unlikely to be suppressed because of supplemented with exogenous nucleic acid.

3, because in general nucleic acid in vivo lacks mainly is liver synthesizing ribonucleotide and nucleoside ability drop, and acellular is the ability drop that substrate generates Deoxydization nucleotide and further synthetic DNA with nucleotide, so but the additional yeast nucleotide that derives from large-scale industrial production can replace the health-care effect of few DNA of resource and hydrolyzate Deoxydization nucleotide thereof fully and can give full play in the body and self synthesize the ability of these materials, thereby solved the few high problem of price of DNA and Deoxydization nucleotide resource, make it to be exclusively used in particular product such as pharmaceutical production (patient injection DNA hydrolyzed solution, the energy fast track rehabilitation) etc., reach the purpose that makes better treatment of nucleic acid resource performance and health-care effect, with the consumption that meets the different needs with the consumer that adapts to different ability to shoulder economicallies, make section's technical ability be each common people of stratum service to greatest extent.

Thereby 4, strengthen cell viability from the special health-care effect of slow down aging in essence and can be from the characteristic of skin absorbs because nucleotide has, nucleate cosmetics industry future is in the ascendant.Now can to have recovered the cell of vigor by nucleic acid synthetic to satisfy the anti-ageing demand of body and be effecting a permanent cure property effect for the SOD that widely uses in the cosmetics, life peptide etc., adopts anti-ageing reactive proteins such as nucleic acid and SOD, life peptide can bring into play it in the cosmetics simultaneously and work in coordination with anti-ageing effect.For giving full play to this synergism, special employing directly permeate through cell membranes enters human body cell and unique ATP(that can replace can not directly enter cell membrane) and COA make the purine nucleosides acid source with the inosine of releasing cell low-energy state, make the cell that is under the mental retardation anaerobic condition particularly cosmetics directly the Skin Cell of service recover normal level, and activation pyruvate oxidation enzyme, it is synthetic to participate in human cellular protein, has active cell, stimulate good actions such as metabolism, receive unapproachable good health-care effects such as existing cosmetics, because of all the components of its design edible and have same health-care effect all, thereby safety and reliability that cosmetics use have been improved greatly.

5, adopt the synthetic tool important function of biological nucleic acid and other important health care function and vitamin and trace element that human body very easily lacks, the metabolism and the effect of nucleic acid have been strengthened, reduce the nucleic acid magnitude of recruitment and reduced product cost, make more people can afford to enjoy modern high-new biological technology products and reach the physical and mental health that brings them thus.

6, with short production cycle, production technology is simple, only requires sterilizing room and weighing, mixing plant etc., so the investment little, instant effect has been avoided environmental pollution, is beneficial to the assurance of product quality.Because of product is that solid powdery and all the components are all soluble in water, be beneficial to keeping, transport and develop the nucleic acid product of all kinds of forms.

7, take to replenish simultaneously purine pyrimidine nucleotide mode, both can guarantee that the nucleic acid in vivo metabolism carried out smoothly to receive the serial health effect of nucleic acid, played simultaneously again that single nucleotide is treated certain or some disease such as IMP, GMP treatment hepatitis and leukocyte, thrombocytopenia etc. and seasoning increases bright effect, also played and strengthened nucleotide collaborative mutually effect of tiring on physiological function, really realized preventing controlling, prevent and treat bonded health care that prevents trouble before it happens and Therapeutic Principle prior to controlling, preventing overweighting with raising.

8, adopt nucleotide to solve the difficult problem that baby children nucleic acid deficiency (contain nucleotide in the human milk and then seldom contain in the Lac Bovis seu Bubali) should not directly be replenished nucleic acid.Because of the quantity of hydrolase nucleic acid a little less than the baby children digestive function very limited.The nucleotide that so not only can replenish in the Lac Bovis seu Bubali makes its nutritional labeling near human milk, the more important thing is the vigor of serial nuclease in the ability that strengthened the bacillary and viral disease of baby children opposing and the inductor, Lac Bovis seu Bubali and milk product are become have the real emulsified milk of disease-resistant function and milk product guaranteeing baby children's growth promoter healthily.This be existing various what is called " humanized milk powder " comprise call oneself " infant nutrition expert " nest's milk powder can't be obtained.

Embodiment:

1, gets AMP or IMP45 gram, UMP44 gram, folic acid 1.4 grams, vitamin C 6.6 grams, sodium selenite 0.14 gram, zinc sulfate 2.7 grams, fully grind well in the rustless steel mortar, (pressing 10ml/ bottle/0.1g calculates to be used to produce nucleotide medicine such as nucleic acid glue Liang (every 0.6 gram), tablet (every 0.3 gram) oral liquid or nutritional solution.）

2, get IMP or GMP45 gram, UMP44 gram, folic acid 1.4 grams, vitamin C 6.6 grams, vitamin B ₁₂0.14 gram, sodium selenite 0.14 gram, zinc sulfate 2.7 grams, in the rustless steel mortar, fully grind well, put into the stainless steel equipment that has agitator, add 10 kilograms of sucrose or glucoses, 200-400 rev/min was stirred 5-10 minute, and content is 1%, is used to make polynucleotide food and beverage, consumption can be by GMP, the special delicate flavour of product tool nucleotide.

3, get Inosine45 gram, CMP or UMP44 gram, being dissolved in water is polynucleotide saturated solution (concentration about 30%), be used to make all kinds of high order nucleic acid skin protection cosmeticss, also can add additive or filleies such as SOD, life peptide isoreactivity material and edibility sucrose fat, produce cosmetics edible fully and that effect is identical, can directly absorb in the use by skin and root of hair cell, improve cell viability, and make the skin of face rejuvenation and have no side effect, consumption is pressed GMP.

4, get GMP45 gram, UMP44 gram, fully grind well in the rustless steel mortar, adding monosodium glutamate by 5% consumption is in the sodium glutamate and mixing (crystal gourmet powder made should be pulverized earlier and be the end), add by the 0.005-0.01% consumption in the flavouring agents such as soy sauce, vinegar, seasoning salt increasing its delicate flavour, and give the flavoring agent health-care effect.

5, get the Inosine45 gram, UMP or CMP44 gram, putting into the rustless steel mortar fully grinds well, pressing the 0.005-0.01% consumption adds in the infant and child food beverages such as milk, baby children powder, replenish the deficiency of Lac Bovis seu Bubali amplifying nucleic acid and induce nuclease and vigor, to produce breast milk milk products near people's milk composition, strengthen the ability of baby children opposing antibacterial and viral disease, guarantee baby children healthy growth and development.

Claims (3)

1, a kind of vitamin micro-element purine pyrimidine dinucleotide nutrient product and manufacture method is characterized in that the raw material consumption (by oven dry weight) of this vitamin micro-element purine pyrimidine dinucleotide nutrient is:

AMP 0-3.5 part

GMP 0-3.6 part

IMP 0-3.5 part

Inosine 0-2.7 part

UMP 0-3.2 part

CMP 0-3.2 part

Folic acid 0-0.1 part

Vitamin B ₁₂0-0.01 part

Vitamin C 0-0.5 part

Sodium selenite 0-0.01 part

Zinc sulfate (or other zinc agent of GB2760-86 permission use, with zinc content conversion in the zinc sulfate) 0-0.2 part.

2, according to the manufacture method of the described vitamin micro-element purine pyrimidine dinucleotide nutrient product of claim 1, it is characterized in that:

(1) preparation of purine pyrimidine dinucleotide

In sterilizing room, press AMP3.5 part, GMP3.6 part, IMP3.5 part, the oven dry weight of Inosine2.7 part appoint get a kind of, by the oven dry weight of UMP3.2 part, CMP3.2 part appoint get a kind of, be added in the stainless steel equipment that has agitator, mixed 5-10 minute with 50-100 rev/min rotating speed, fully mixing is airtight standby.

(2), the preparation of compound vitamin

In sterilizing room, get 1 part in folic acid, vitamin B by oven dry weight ₁₂0.1 part, 5 parts of vitamin Cs grind fully to grind well in the body at rustless steel and are not (2-4 minute), and are airtight standby.

(3), the preparation of compound microelement

In sterilizing room, get 0.1 part of the sodium selenite of oven dry weight, 2 parts in zinc sulfate (when using other zinc agent of GB2760-86, converting corresponding weight quota) with the zinc content in the zinc sulfate, it is standby fully to grind well (2-4 minute) back in the rustless steel mortar.

(4), the preparation of vitamin micro-element purine pyrimidine dinucleotide nutrient product, in sterilizing room, with formula for a product and the ratio weighing of purine pyrimidine dinucleotide, compound vitamin and compound microelement in different purposes among the embodiment, in having the stainless steel equipment of agitator, stirred 5-10 minute with 200-400 rev/min rotating speed, fully mixing product.

3, purposes according to the described vitamin micro-element purine pyrimidine dinucleotide nutrient of claim 1, it is characterized in that this product and produce ucleotides medicine such as glue Liang except that can be used as, tablet, outside the purine pyrimidine dinucleotide host of oral liquid or nutritional solution, also can be used as varieties of food items, beverage, the nucleic acid additive of flavoring agent and cosmetics, be made into height that series has the nucleic acid health care food of tiring, beverage, flavoring agent and cosmetics, consumption is pressed GMP, as various beverages, sweet food, salty food, soup stock, soy sauce, vinegar, the powerful monosodium glutamate of nucleic acid specially fresh, cold cream, skin care liquid etc.