CN109758267A - A kind of Bone Defect Repari porous support and preparation method thereof - Google Patents
A kind of Bone Defect Repari porous support and preparation method thereof Download PDFInfo
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- CN109758267A CN109758267A CN201910166837.6A CN201910166837A CN109758267A CN 109758267 A CN109758267 A CN 109758267A CN 201910166837 A CN201910166837 A CN 201910166837A CN 109758267 A CN109758267 A CN 109758267A
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- beam column
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Abstract
The present invention relates to Design for Medical Device technical fields, disclose a kind of Bone Defect Repari porous support, including several structural units, the outer profile of the structural unit is in square prism shape, the bottom surface side length of this square prism is a, height is h, the structural unit includes support beam column, center beam column and connecting rod, the support beam column is respectively arranged at four inclines of square prism, the center beam column is set to the center of square prism, and it is parallel contour with support beam column, connecting rod is correspondingly arranged between the support beam column and center beam column, the section radius of the support beam column and center beam column is R, several building block arrays form porous support.The present invention also provides a kind of preparation methods of Bone Defect Repari porous support.This porous support has many advantages, such as that porosity is high, elasticity modulus is low, bearing capacity is high.
Description
Technical field
The present invention relates to Design for Medical Device technical fields, and in particular to a kind of Bone Defect Repari porous support and its preparation side
Method.
Background technique
Implantation material reparation is that most advantageous one kind is repaired in large area bone defect healing method caused by wound or disease
Multiple means.Such as femur comminuted fracture, required implantation material need low elastic modulus matching autologous bone to prevent stress shielding, simultaneously
Implantation material is prevented to be broken with certain bearing capacity.Metal porous implant can satisfy the demand, and have good biology
Compatibility.
In existing product, titanium alloy implant has absolute advantage, because of its excellent mechanical compatibility and biology
Compatibility.Titanium alloy elastic modulus is more nearly with respect to other metals and natural bone tissue, without pathogenic or few pathogenic in alloy
Element.Nevertheless, the elasticity modulus of solid titanium alloy implant is still higher than natural bone, porous support comes into being as a result,.
Implant porosity can be improved in the design of porous engineering rack, reduces its elasticity modulus, increases blood transportation channel, promotes thin
Born of the same parents' adherency and proliferation.Need to balance the requirement of both elasticity modulus and intensity in porous support design process.The low bullet of pursuit simply
It is inadequate that property modulus may cause the implant bearing capacity, leads to implant fracture failure.And it excessively pursues bearing capacity and will lead to
The limitation of engineering rack elasticity modulus is higher than nature bone tissue, so that stress shielding occur leads to implant initial failure.In addition, closing
Reason structure design can reduce the residual stress in porous support, reduce printing precision caused by residual stress and stress collection is medium
Problem.Therefore, a kind of reasonable cellular construction is researched and developed to the applicability for improving metal implant, promotes Bone Defect Repari to have important
Scientific meaning and practical value.
Porous support unit is mostly with cube lattice structure or positive tetrahedron diamond-like knot in existing implant
Structure, sphere nodes are arranged in cube apex, body-centered, face heart position in cellular construction, and are connected with each other by cylindrical connecting rod.
Structure described in 107847327 A disclosure of Chinese patent CN is positive tetrahedron diamond lattice structure, but its structure phase
To complicated, rib is longer, intensity is lower, the two-way demand of porosity and intensity can not be met simultaneously.Chinese patent
Cellular construction described in CN107174382 A disclosure is body-centered cubic lattic structure, specific strong without indicating in patent
Degree value through Experimental Comparison, it is found that its intensity is only 39.04MPa referring to its design method, anti-well below natural bone tissue
Compressive Strength 100-230MPa.Porous support described in Chinese patent CN108601662 A disclosure is irregular eutectic, although
The structure more closely, still design process is relative complex, takes a long time with body bone tissue structure, is unfavorable for traumatic bone and repairs
Time control in multiple treatment.Above structure unit rack mechanical property can match in a certain range with natural bone tissue,
Realize the purpose for promoting bone uptake, but longer rib length causes overall structural strength lower, bearing capacity is insufficient, to limit
Bone cell growth microenvironment, influences osseointegration.
Summary of the invention
The purpose of the invention is to overcome above the shortcomings of the prior art, a kind of low elastic modulus, low is provided
The Bone Defect Repari porous support of residual stress, suitable porosity and bearing capacity.The present invention also provides a kind of Bone Defect Reparis with porous
The preparation method of bracket.
The purpose of the present invention is realized by the following technical solution:
A kind of Bone Defect Repari porous support, including several structural units, the outer profile of the structural unit are in square prism
Shape, the bottom surface side length of this square prism are a, and incline height is h, and the structural unit includes support beam column, center beam column and company
Extension bar, the support beam column are respectively arranged at four inclines of square prism, and the center beam column is set to square prism
Center, and it is parallel contour with support beam column, connecting rod, the support are correspondingly arranged between the support beam column and center beam column
The section radius of beam column and center beam column is R, wherein R >=0.5mm；Several building block arrays form porous support,
Wherein, the support beam column between the structural unit in same layer is connected with each other, the center sill of the structural unit in same row
It is connected with each other between column, supports and be also connected with each other between beam column.The support beam column is cylindric in a quarter, the supporting beam
Intersection between two right-angle surface of column is the incline of square prism, and the curved surface of the support beam column is towards center beam column.
Further, the section of the connecting rod is rounded, this circular radius is r1, wherein The connecting rod is circular in a quarter, and the radius of this annulus is r2, wherein
Further, four connecting rods are divided into two groups, wherein the inner ring surface of one group of connecting rod is oppositely arranged, separately
The outer ring surface of one group of connecting rod is oppositely arranged.
Further, four connecting rods are divided into two groups, and the inner ring surface of every group of connecting rod is oppositely arranged.
Further, the inner ring surface of four connecting rods successively at arranging clockwise or counterclockwise.
Further, the support beam column is cylindric in a quarter, the intersection between support two right-angle surface of beam column
For the incline of square prism, the curved surface of the support beam column is towards center beam column.
Further, the cylindrical surface of the center beam column is divided into four joint faces, four companies along its circumferencial direction
One end of extension bar is connected with the center of corresponding joint face respectively, and the other end of four connecting rods is respectively and relatively
The center connection for the support beam column answered.
Further, the porosity of the porous support is 50%-90%.
A kind of preparation method of Bone Defect Repari porous support, includes the following steps:
S01, by the model of computer aided design software rendering architecture unit, porous branch will be formed after the Model array
The model of frame；
S02, layered shaping is carried out to the model of porous support, and is translated into SLI formatted file；
S03, the file in S02 is imported into metallic print equipment, using laser sintering technology printing shaping.
Further, the porous support uses pure titanium powder, titanium alloy powder, cobalt-chromium alloy powder or powder of stainless steel
It is printed through laser sintering technology.
The present invention has the following advantages compared with the prior art:
1, structural unit of the invention, structure is simple, and design rationally, omits sphere nodes, building block array composition
After porous support, the support beam column between the structural unit in same layer is connected with each other, the structural unit in same row
It is connected with each other between the beam column of center, supports and be also connected with each other between beam column, this setting not only improves the bearing capacity of porous support, also
Make porous support that there is suitable porosity.
2, support beam column circular in a quarter in structural unit of the invention, when multiple building block arrays are at porous
When bracket, cylindrical or half cylinder is spliced between adjacent support beam column, so that the structure of porous support is more
It is firm, and one end of connecting rod is connect with the center of the curved surface of support beam column, the centre bit of the other end and centered cylinder
Connection is set, intersecting lens is simple, and the stress of no complexity is concentrated, and avoiding stress concentration in porous support leads to breakage problem.
3, the deformable range of connecting rod is increased using the connecting rod in circular ring shape in the present invention, reduces connecting rod and support
Elasticity modulus and residual stress when beam column, center beam-to-column joint reduce entirety deformation and destruction due to caused by residual stress；
There are certain proportionate relationships between the radius of circular ring shape and the radius of connecting rod and the diameter of center beam column, can be according to patient's
Different demands adjust aperture and the porosity of porous support；Because the connecting rod in structural unit is in circular ring shape, specifically used
When, the arrangement of connecting rod can form different pore structures, to meet the needs of different patients.
Detailed description of the invention
Fig. 1 is the shaft side figure of the Bone Defect Repari porous support of the embodiment of the present invention 1；
Fig. 2 is the top view of the Bone Defect Repari porous support of the embodiment of the present invention 1；
Fig. 3 is the shaft side figure of the structural unit of the embodiment of the present invention 1；
Fig. 4 is the main view of the structural unit of the embodiment of the present invention 1；
Fig. 5 is the top view of the structural unit of the embodiment of the present invention 1；
Fig. 6 is in the embodiment of the present invention 1 with the data variation figure between porosity and compression strength；
Fig. 7 is in the embodiment of the present invention 1 with the data variation figure between porosity and elasticity modulus；
Fig. 8 is the shaft side figure of the Bone Defect Repari porous support of the embodiment of the present invention 2；
Fig. 9 is the top view of the Bone Defect Repari porous support of the embodiment of the present invention 2；
Figure 10 is the top view of the structural unit of the embodiment of the present invention 2；
Figure 11 is the shaft side figure of the Bone Defect Repari porous support of the embodiment of the present invention 3；
Figure 12 is the top view of the Bone Defect Repari porous support of the embodiment of the present invention 3；
Figure 13 is the top view of the structural unit of the embodiment of the present invention 3；
In figure, 1 is porous support；2 be structural unit；3 be support beam column；4 be center beam column；5 be connecting rod.
Specific embodiment
Present invention will be further explained below with reference to the attached drawings and examples.
Embodiment 1:
A kind of Bone Defect Repari porous support as Figure 1-Figure 5, including several structural units 2, the structural unit 2
Outer profile is in square prism shape, and the bottom surface side length of this square prism is a, and incline height is h, and the structural unit 2 includes support
Beam column 3, center beam column 4 and connecting rod 5, the support beam column 3 are respectively arranged at four inclines of square prism, the center
Beam column 4 is set to the center of square prism, and parallel contour with support beam column 3, between the support beam column 3 and center beam column 4
It is correspondingly arranged on connecting rod 5, the section radius for supporting beam column 3 and center beam column 4 is R, wherein R >=0.5mm；It is several
The continuous array of structural unit 2 is to form porous support 1, wherein 3 phase of support beam column between the structural unit 2 in same layer
It connects, is connected with each other between the center beam column 4 of the structural unit 2 in same row, support and be also connected with each other between beam column 3.
Porous support 1 in the present invention designs rationally, and sphere nodes are omitted, and not only increases the bearing capacity of porous support 1, also makes more
Hole bracket 1 has suitable porosity.Porous support 1 in the present invention is formed by several 2 arrays of structural unit, porous support
1 appearance profile can be the geometry of rule, can also be the demand personalization customization with patient.
The section of the connecting rod 5 is rounded, this circular radius is r1, whereinThe company
Extension bar 5 is circular in a quarter, and the radius of this annulus is r2, whereinUsing in the cricoid company of quadrant
Extension bar 5 can increase the deformable range of connecting rod, and the residual stress generated when reducing by 2 array of structural unit is reduced because remnants are answered
Entirety deformation and damage caused by power.By adjusting the side length a of square prism, the high h of incline, 5 radius r1 of connecting rod, annular radii
R2 supports the radius R of beam column 3 and center beam column 4, so that the parameters such as porosity and pore diameter are controlled, to meet porous support 1
The elasticity modulus to match with body bone tissue reduces or even eliminates stress shielding phenomenon.
Four connecting rods 5 are divided into two groups, wherein the inner ring surface of one group of connecting rod 5 is oppositely arranged, another group
The outer ring surface of connecting rod 5 is oppositely arranged.This setting keeps the size of 1 internal orifice dimension of porous support unified.Because connecting rod 5 in four/
One circular ring shape, therefore the hole in porous support 1 may be designed to different structures, meet the needs of different patients.
The support beam column 3 is cylindric in a quarter, and the intersection between described support 3 liang of right-angle surfaces of beam column is positive tetragonous
The incline of column, the curved surface of the support beam column 3 is towards center beam column 4.When multiple 2 continuous arrays of structural unit, adjacent branch
Support beam column 3 can be spliced into cylindric or semi-cylindrical, improve the stability of porous support 1.
The cylindrical surface of the center beam column 4 is divided into four joint faces along its circumferencial direction, and the one of four connecting rods 5
End respectively with the center of corresponding joint face connect, the other end of four connecting rods respectively with corresponding support
The center of area (i.e. the center of curved surface) of the curved surface of beam column connects.Centre bit of four connecting rods 5 on the cylindrical surface of center beam column 4
It sets and is uniformly distributed.This setting keeps connecting rod 5 and the intersection line position for supporting beam column 3 and center beam column 4 to connect formation simple, nothing
Complicated stress is concentrated, so that stress in porous support 1 be avoided to concentrate the breakage problem generated.
The porosity of the porous support 1 is 50%-90%.Porosity can be adjusted according to the demand of patient.
A kind of preparation method of Bone Defect Repari porous support, includes the following steps:
S01, the model for passing through computer aided design software (CAD) rendering architecture unit 2, will form after the Model array
The model of porous support 1；
S02, the model of porous support 1 is carried out layered shaping (utilizing Materialise Magics Slice Software), and
It is translated into SLI formatted file；
S03, the file in S02 is imported into metallic print equipment (EOS M280 metal 3D printing equipment), is burnt using laser
Knot technology printing shaping.
Selective laser sintering is carried out using EOS M280 metallic print machine and processes Ti-6Al-4V (titanium alloy) powder, is beaten
The porous support 1 that print design porosity is 50%-90%, and compression verification is carried out using omnipotent mechanics machine.Specific test
As a result it see the table below: (according to data in table it is found that the compression strength and elasticity modulus of porous support 1 can be matched with natural bone) tool
Volume data curve is referring to Fig. 6 and Fig. 7, and wherein Fig. 6 is the porous support 1 that different porosities are printed using Ti-6Al-4V powder
The variation diagram of compression strength；Fig. 7 is the elasticity modulus that the porous support 1 of different porosities is printed using Ti-6Al-4V powder
Variation diagram.
| Porosity % | Compression strength Mpa | Elastic modulus G pa |
| 50 | 266 | 6.85 |
| 60 | 234 | 6.90 |
| 70 | 180 | 5.42 |
| 80 | 144 | 4.49 |
| 90 | 33 | 2.35 |
Experimental comparison's example:
EOS M280 metallic print machine carries out selective laser sintering and processes Ti-6Al-4V powder, printed design porosity
For 50% lattice structure engineering rack, and compression verification is carried out using omnipotent mechanics machine.Lattice structure unit rack its
Compression strength be 39~63MPa, elasticity modulus be 1~3GPa, it is seen that although the elasticity modulus of lattice structure unit rack with from
Right bone photo matching, but it is relatively weak in terms of its compression strength.(this comparative example is based on Chinese patent CN107174382A and discloses text
This)
Embodiment 2:
The present embodiment is in addition to following technical characteristic with embodiment 1:
Selective laser sintering is carried out using EOS M280 metallic print machine and processes pure titanium powder, and printed design porosity is
60% porous support 1, and compression verification is carried out using omnipotent mechanics machine.Its compression strength is 130MPa, elasticity modulus
For 6.05GPa, it is seen that matched with natural bone in terms of compression strength, elasticity modulus.
Embodiment 3:
The present embodiment is in addition to following technical characteristic with embodiment 1:
Selective laser sintering, which is carried out, using EOS M280 metallic print machine processes cobalt-chromium alloy powder, printed design hole
The porous support 1 that rate is 70%, and compression verification is carried out using omnipotent mechanics machine.Its compression strength is 301MPa, elasticity
Modulus is 12.85GPa, by adjusting the porosity of porous support 1 to meet the needs of different patients.
Embodiment 4:
The present embodiment is in addition to following technical characteristic with embodiment 1:
Selective laser sintering processing stainless steel powder, printed design porosity are carried out using EOS M280 metallic print machine
For 90% porous support 1, and compression verification is carried out using omnipotent mechanics machine.Its compression strength is 30.3MPa, springform
Amount is 9.05GPa, by adjusting the porosity of porous support 1 to meet the needs of different patients.
Embodiment 5:
This implementation 1 is in addition to following technical characteristic with embodiment 1:
As Figure 8-Figure 10, four connecting rods 5 are divided into two groups, and the inner ring surface of every group of connecting rod 5 is set relatively
It sets.This is arranged so that the hole generated after 2 array of structural unit is circular configuration.
Embodiment 6:
The present embodiment is except following technical characteristic is with embodiment 1:
As shown in figures 11-13, the inner ring surface of four connecting rods 5 is successively at arranged clockwise.This is arranged so that knot
There are two types of structures for the hole tool generated after 2 array of structure unit.
Above-mentioned specific embodiment is the preferred embodiment of the present invention, can not be limited the invention, and others are appointed
The change or other equivalent substitute modes what is made without departing from technical solution of the present invention, are included in protection of the invention
Within the scope of.
Claims (10)
1. a kind of Bone Defect Repari porous support, it is characterised in that: including several structural units, the outer profile of the structural unit is in
Square prism shape, the bottom surface side length of this square prism are a, and incline height is h, and the structural unit includes support beam column, center
Beam column and connecting rod, the support beam column are respectively arranged at four inclines of square prism, and the center beam column is set to just
The center of quadrangular, and it is parallel contour with support beam column, it is correspondingly arranged on connecting rod between the support beam column and center beam column,
The section radius of the support beam column and center beam column is R, wherein R >=0.5mm；Several building block arrays are formed
Porous support, wherein the support beam column between the structural unit in same layer is connected with each other, the structural unit in same row
Center beam column between be connected with each other, support beam column between be also connected with each other.
2. Bone Defect Repari porous support according to claim 1, it is characterised in that: the section of the connecting rod is rounded,
This circular radius is r1, whereinThe connecting rod is circular in a quarter, the radius of this annulus
For r2, wherein
3. Bone Defect Repari porous support according to claim 2, it is characterised in that: four connecting rods are divided into two
Group, wherein the inner ring surface of one group of connecting rod is oppositely arranged, the outer ring surface of another group of connecting rod is oppositely arranged.
4. Bone Defect Repari porous support according to claim 2, it is characterised in that: four connecting rods are divided into two
Group, and the inner ring surface of every group of connecting rod is oppositely arranged.
5. Bone Defect Repari porous support according to claim 2, it is characterised in that: the inner ring surface of four connecting rods according to
It is secondary at arranging clockwise or counterclockwise.
6. Bone Defect Repari porous support according to claim 1, it is characterised in that: the support beam column is in quadrant
Column, the intersection supported between two right-angle surface of beam column are the incline of square prism, and the curved surface of the support beam column is in
Heart beam column.
7. Bone Defect Repari porous support according to claim 1, it is characterised in that: the cylindrical surface of the center beam column is along it
Circumferencial direction is divided into four joint faces, and one end of four connecting rods connects with the center of corresponding joint face respectively
It connects, the other end of four connecting rods is connected with the center of corresponding support beam column respectively.
8. Bone Defect Repari porous support according to claim 1, it is characterised in that: the porosity of the porous support is
50%-90%.
9. a kind of preparation method of Bone Defect Repari porous support, it is characterised in that: include the following steps,
S01, by the model of computer aided design software rendering architecture unit, porous support will be formed after the Model array
Model；
S02, layered shaping is carried out to the model of porous support, and is translated into SLI formatted file；
S03, the file in S02 is imported into metallic print equipment, using laser sintering technology printing shaping.
10. the preparation method of Bone Defect Repari porous support according to claim 9, it is characterised in that: the porous support
It is printed using pure titanium powder, titanium alloy powder, cobalt-chromium alloy powder or powder of stainless steel through laser sintering technology.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111494060A (en) * | 2020-04-28 | 2020-08-07 | 河北科技大学 | Method for constructing bone implant and bone implant structural unit |
| CN112276114A (en) * | 2020-11-03 | 2021-01-29 | 西安航天发动机有限公司 | High-reliability columnar supporting structure forming method for metal additive manufacturing |
| CN113440648A (en) * | 2021-03-16 | 2021-09-28 | 中国科学院合肥物质科学研究院 | BBG/PCL composite porous bone scaffold and preparation method thereof |
| CN114587713A (en) * | 2022-03-03 | 2022-06-07 | 广州华睿医疗器械有限公司 | Porous support structure for bone repair implant and processing method thereof |
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| CN112276114A (en) * | 2020-11-03 | 2021-01-29 | 西安航天发动机有限公司 | High-reliability columnar supporting structure forming method for metal additive manufacturing |
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| CN114587713A (en) * | 2022-03-03 | 2022-06-07 | 广州华睿医疗器械有限公司 | Porous support structure for bone repair implant and processing method thereof |
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