CN115090903B - Medical implant based on molecular sieve functional element and preparation method thereof - Google Patents
Medical implant based on molecular sieve functional element and preparation method thereof Download PDFInfo
- Publication number
- CN115090903B CN115090903B CN202210508554.7A CN202210508554A CN115090903B CN 115090903 B CN115090903 B CN 115090903B CN 202210508554 A CN202210508554 A CN 202210508554A CN 115090903 B CN115090903 B CN 115090903B
- Authority
- CN
- China
- Prior art keywords
- molecular sieve
- implant
- functional element
- porous
- medical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
- B22F10/30—Process control
- B22F10/38—Process control to achieve specific product aspects, e.g. surface smoothness, density, porosity or hollow structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
- B22F10/20—Direct sintering or melting
- B22F10/28—Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
- B22F10/80—Data acquisition or data processing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y50/00—Data acquisition or data processing for additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/16—Materials with shape-memory or superelastic properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P10/00—Technologies related to metal processing
- Y02P10/25—Process efficiency
Abstract
The invention discloses a medical implant based on molecular sieve functional elements, and a preparation method and application thereof. Firstly, selecting a unit of a molecular sieve structure, reconstructing a unit model to generate a molecular sieve functional element, including but not limited to definition of pore parameters such as pore diameter, rod diameter, porosity, unit size and the like, designing the molecular sieve porous structure into a gradient porous structure with the rod diameter smoothly changed, outputting a porous implant prosthesis model after the pore parameters are optimized, and forming by using an additive manufacturing method. The invention creatively uses the molecular sieve structure as the unit structure of the porous medical implant, optimizes the parameters of porosity, aperture and the like of the molecular sieve structure, ensures that the designed molecular sieve functional element meets the requirements of different biological behaviors such as tissue cell adhesion, proliferation, differentiation and the like and meets the technological limit of additive manufacturing technology. The medical implant based on the molecular sieve functional element prepared by the invention has wide application prospect in artificial prosthesis.
Description
Technical Field
The invention belongs to the field of biomedical functional materials and additive manufacturing, and particularly relates to a medical implant based on molecular sieve functional elements and a preparation method thereof.
Background
Due to the rapid population growth and aging trend, the demands for bone implants are rapidly increasing in the society today, and clinically, higher demands are being made on various properties of external implants that can be implanted into the human body. Among the materials commonly used in metal implants are stainless steel, cobalt-based alloys and titanium alloys. However, clinical researches find that the alloy materials mainly have the following problems in the service process: the elastic modulus of the alloy material is too high, taking Ti6Al4V alloy as an example, and is about 110GPa and is far higher than the human bone modulus (0.022-21.8 GPa). The alloy material with too high elastic modulus can be implanted into a human body for a long time to cause the original bone tissue function to be degraded and reabsorbed, so that the phenomenon of stress shielding is caused, and implantation failure is caused. Therefore, there is a need to develop artificial implants with biocompatibility and mechanical properties closer to those of natural bones of the human body.
Structurally, the special structure of the porous structure greatly reduces the elastic modulus of the porous structure compared with that of a compact material, and effectively reduces the stress shielding effect. For this reason, porous structures are increasingly replacing dense materials as ideal candidates for implants. The porous structure can effectively improve the stress transmission between the implant and human bone, so that better biological combination is obtained between the implant and bone tissue, and meanwhile, as the porous structure has larger surface area, cells can be supplemented and permeated into the structure from the surrounding bone tissue, bone regeneration and vascularization are promoted, cell proliferation and adhesion are facilitated, and the porous structure has great potential in biomedical implants. However, the porous configuration adopted by the biomedical implant has a plurality of problems, such as the reduction of the elastic modulus and the great reduction of the strength, and the two cannot be achieved; the porous configuration is prone to stress concentration in the loaded environment, reducing the useful life of the implant. Therefore, a new porous structure configuration is required, the elastic modulus is reduced, the mechanical matching properties such as strength and the like are improved, and certain cell behavior guiding requirements are met.
The molecular sieve is a micro-nano material with a regular and uniform pore structure, has wide application in the fields of drug carriers and antibacterial agents, and is also widely applied to the preparation of molecular sieve coatings combined with alloy implants. The molecular sieve has a special pore canal structure, a huge specific surface area and a multi-scale aperture size, so that the molecular sieve has a strong adsorption capacity, can reversibly adsorb/release functional ions or drug molecules, and can promote the implant to obtain better osseointegration capacity and antibacterial performance by doping bioactive elements or antibacterial elements into the micro/nano composite structure coating, thereby prolonging the service life of the implant. However, the molecular sieve structure itself belongs to a micro-level structure and cannot be directly applied to the implant prosthesis, so that the molecular sieve structure needs to be further subjected to parameterization redesign so as to meet various different requirements.
In recent years, the concept of gradient porous structures has come into the field of view of researchers with porous medical implants. Compared with a porous structure with uniform porosity, the gradient porous structure is more beneficial to improving the success rate of implantation of the medical implant due to the changed porosity. The current mainstream view is as follows: the pore diameter of 100 μm is favorable for cell adhesion; the pore diameter of 200 μm is suitable for the growth of fiber; the pore diameter of 300-400 mu m is beneficial to cell adhesion, proliferation and migration, can promote osteoblast proliferation and is beneficial to bone regeneration; pore diameters exceeding 400 μm facilitate vascular ingrowth. Wherein a single size pore size of less than 500 μm can cause obstruction to the flow of cells and tissue, forming a blockage. Meanwhile, while large pore sizes are advantageous for osteogenesis due to the absorption and ion exchange of osteoinductive factors, larger pore sizes also result in excessive fibrous ingrowth. Therefore, various single-size pore diameters have certain biological defects, and the design and preparation of the gradient porous structure gradually become a research hot spot in the field of medical implantation.
The additive manufacturing technology is taken as a new alloy preparation method, has great application potential in the field of preparing porous materials, breaks through the limitation of the traditional processing method, can effectively regulate and control the shape, the size, the distribution condition and the like of a pore structure, and is one of the most favorable processes for forming the porous structure.
At present, additive manufacturing technology is mostly used for printing traditional porous structures, such as cube holes, rhombic dodecahedron and the like, and the elastic modulus of the printed porous structure is as low as 3.4GPa, and the compressive strength is 200MPa (Addit Manuf,34 (2020) 101264). Compared with a compact titanium alloy material, the elastic modulus of the porous structure is obviously reduced, but the porous structure has high structural rigidity and single pore diameter, and can not simultaneously meet different biological cell behaviors, so that the design of the porous implant needs to consider not only the mechanical property requirement, but also the biological tissue cell contact guiding behavior and the additive manufacturing process limitation.
Disclosure of Invention
To solve the disadvantages and shortcomings of the prior art, a primary object of the present invention is to provide a method for preparing a medical implant based on molecular sieve functional motifs.
It is another object of the present invention to provide a medical implant based on molecular sieve functional motifs made by the above method.
The invention aims at realizing the following technical scheme:
a method for preparing a medical implant based on molecular sieve functional motifs, comprising the steps of:
(1) Building molecular sieve functional motifs: selecting a molecular sieve unit with central symmetry characteristic representing the integral porous structure characteristic of the molecular sieve, drawing a pore parameter design domain of the molecular sieve unit according to the biological cell function requirement and the additive manufacturing process limit constraint, determining each pore parameter of the molecular sieve unit according to the parameter design domain, and carrying out physical model reconstruction on the molecular sieve unit by modeling software to construct a molecular sieve functional element;
(2) Designing a molecular sieve gradient porous structure: designing the molecular sieve functional element structure in the step (1) into a gradient porous structure corresponding to the smooth transition change of the rod diameter, and constructing the molecular sieve functional element of the gradient porous structure;
(3) And integrating and outputting the molecular sieve functional element and the implant prosthesis model: generating an implant prosthesis model in software, inputting the molecular sieve functional element in the step (1) or the molecular sieve functional element in the step (2) with the gradient porous structure into the software as a basic unit model for filling corresponding parts of the implant prosthesis model, and generating a porous implant prosthesis model;
(4) Additive manufacturing, forming and preparing: and (3) repairing the part model of the molecular sieve functional element in the step (1) or the molecular sieve functional element in the step (2) or the porous implant prosthesis model in the step (3) by using software, introducing the part model into additive manufacturing equipment for customized partition printing and forming after slicing treatment, and obtaining the medical implant solid part or prosthesis through post treatment.
The medical implant based on the molecular sieve functional element can be formed and prepared by the method, the molecular sieve porous part has low elastic modulus, high strength and high energy absorptivity, the implantation success rate and the implantation service life of the medical implant are greatly improved, meanwhile, the porous pore parameters of the molecular sieve can be flexibly regulated and controlled to match different biological tissue cell behaviors and meet the technological limit of additive manufacturing, the preparability and the formability of the high-performance molecular sieve porous part are ensured, and the design of the molecular sieve structure provides new thought and direction for preparing the high-quality porous part.
Further, the molecular sieve functional element physical model reconstruction process in the step (1) is as follows: each strut in the molecular sieve unit is simplified into a line, a line diagram of the molecular sieve unit is drawn in software, and then each line frame is taken as a central axis, and the line diagram is rotated for one circle with a specified radius (half of the rod diameter) and materialized to obtain the molecular sieve functional primitive.
Further, the modeling software in the step (1) is CAD modeling software SolidWorks.
Further, the various pore parameters in the step (1) include parameters such as porosity, pore diameter, rod diameter and unit size.
Further, the biological cell function requirements in step (1) are specifically: the pore parameter value range comprises the unit size (molecular sieve unit) of 3-4 mm and the porosity of 60% -90%; the aperture range is 200-1200 mu m; the additive manufacturing process limitations are specifically: the diameter of the rod ranges from 200 mu m to 1000 mu m.
Further, the molecular sieve functional unit in the step (1) is specifically: the diameter and aperture of the molecular sieve functional element can be flexibly regulated and controlled, and the aperture within the range of 200-1200 mu m and the diameter variation within the range of 200-1000 mu m can be realized, thereby simultaneously meeting the functional requirements of biological cells and the limit of additive manufacturing technology.
Further, the pore parameter design domain in the step (1) specifically includes: the pore diameter of 200-1200 mu m, the porosity of 60-90% and the rod diameter of 200-1000 mu m are used as constraint conditions to draw the pore parameter design domain of the molecular sieve functional element.
Further, the gradient porous structure with smooth transition change of the corresponding rod diameter in the step (2) refers to a gradient porous structure with smooth transition change of the corresponding rod diameter in the range of 200-1000 μm.
Further, the design of the gradient porous structure of the molecular sieve in the step (2) adopts a gradient porous design software Grasshopper platform.
Further, the filling of the corresponding site in step (3) means that the porous implant prosthesis is divided into a dense region and a porous region, and the porous region is filled with molecular sieve functional elements.
Further, in the step (3), the software is Rhino.
Further, the software for model repair and slicing in step (4) was Materialise Magics and RP-Tools, respectively.
Further, the medical alloy used in the additive manufacturing in the step (4) is at least one of medical pure titanium, medical TC4, ti-Nb, ti-Mo, ti-Zr, ti-Nb-Hf, ti-Nb-Zr medical beta titanium alloy, niTi shape memory alloy, coCr alloy and medical stainless steel.
Further, the medical alloy used in the additive manufacturing in the step (4) is medical titanium alloy spherical powder, the preparation method is a plasma atomization method, an electrode induction smelting gas atomization method or a plasma rotary electrode atomization powder preparation method, the particle size of the powder ranges from 15 mu m to 65 mu m, and the oxygen content of the powder is lower than 300ppm. Drying at 60-80 ℃ before printing and forming, wherein the preheating temperature of the substrate is 200 ℃.
Further, the customized partition print in step (4) is shaped as: the compact area and the porous area of the medical implant are formed by partition printing through adjusting technological parameters, specifically, the laser power range of the compact area is 200-240W, the laser scanning speed range is 1000-1200 mm/s, the laser scanning interval range is 60-80 mm, and the layer thickness range is 30-50 mm; the laser power range of the porous area is 160-200W, the laser scanning speed range is 1200-2000 mm/s, the laser scanning interval range is 60-80 mm, and the layer thickness range is 30-45 mm.
Further, the additive manufacturing apparatus in step (4) is one of CONCEPT LASER M2, EOS M280/290, SLMsolution 125/250/280.0/500, RENISHAW 400, BLT-S320, arcam A2x, arcam Q20, QEBAM Lab200, and Qbeam 3D.
Further, the post-treatment process in the step (4) comprises: ultrasonic cleaning is carried out for 0.5-1 hour by using a mixed solution of acetone, 2-propanol, hydrofluoric acid and ultrapure water (volume ratio is 1:1:1:7), drying is carried out for 10-12 hours in an oven at 40-60 ℃, then the obtained product is placed in an inert atmosphere furnace at 1300 ℃ for heating for 1-2 hours, then the obtained product is cooled along with the furnace, and sand blasting treatment is carried out by adopting a sand blaster with the model of LV 6050A.
A medical implant based on molecular sieve functional elements is prepared by the method.
The obtained medical implant (porous part) has low elastic modulus (0.5-5 GPa), high yield strength (50-200 MPa) and high energy absorption efficiency (more than 70%). Such implants include joint implants (hip, knee implants), spinal implants (internal fixation implants, minimally invasive implants, etc.), shoulder implants (scapula implants, etc.), craniomaxillofacial implants (mandibular implants, skull implants, etc.), ankle implants (ankle implants, toe bone implants, etc.), and other site implants (e.g., sternum implants, etc.).
The preparation method of the invention has the principle that: firstly, selecting a unit of a molecular sieve structure, reconstructing a unit model to generate a molecular sieve functional element, including but not limited to definition of pore parameters such as pore diameter, rod diameter, porosity, unit size and the like, further designing the molecular sieve functional element structure into a gradient porous structure with the rod diameter smoothly changed, integrating the molecular sieve functional element or the molecular sieve gradient porous structure with an implant prosthesis model, outputting the porous implant prosthesis model, and forming and preparing by using an additive manufacturing method. According to the physical properties of different medical alloy powders, the technological parameters are adjusted to carry out customized zonal additive manufacturing, printing and forming, so that the mechanical properties and forming quality of the compact part and the porous part of the porous implant are regulated and controlled, and the biological and mechanical property requirements of the medical implant are met.
Compared with the prior art, the invention has the following advantages:
1. compared with the traditional porous structure, the porous functional element based on the molecular sieve structure has low elastic modulus, high strength and high energy absorptivity, and greatly improves the implantation success rate and the implantation service life of the medical implant.
2. The pore parameters of the functional primitives of the molecular sieve designed by the invention can be flexibly regulated and controlled to match different biological tissue cell behaviors and meet the technological limit of additive manufacturing technology, thereby ensuring the preparability and formability of the porous parts of the high-performance molecular sieve.
3. Compared with the traditional casting forming and plastic forming processes, the material-increasing manufacturing process can be used for manufacturing parts with various complex shapes, meets the requirement of personalized design, and has high material utilization rate and low processing cost.
Drawings
FIG. 1 is a molecular sieve functional primitive pore parameter design domain. Wherein the constraint conditions are: the pore diameter value range is 200-1200 mu m, the rod diameter value range is more than 200 mu m, the porosity value range is 60-90%, and the shaded area represents the design domain of the pore parameters of the molecular sieve functional element. Wherein (a) is the large pore size constraint of the molecular sieve functional element and (b) is the small pore size constraint of the molecular sieve functional element.
FIG. 2 is a pure Ti linear gradient porous member based on molecular sieve functional units in example 1, with a rod diameter variation range of 364 μm-748 μm, a yield strength of 62.5MPa, an elastic modulus of 2.47GPa, and an energy absorption We=0.5 of 58MJ/m 3 The energy absorption efficiency was 88%.
FIG. 3 is a schematic diagram of a NiTi axial gradient porous member based on molecular sieve functional units in example 2, with a rod diameter variation range of 364 μm-748 μm, a yield strength of 62.7MPa, an elastic modulus of 2.45GPa, and an energy absorption We=0.5 of 61.7MJ/m 3 The energy absorption efficiency was 91%.
FIG. 4 shows a TiNbZrTa cylindrical gradient porous part based on molecular sieve functional elements in example 3, with a rod diameter ranging from 394 μm to 712 μm, and a yield strength of 74.4MPa, an elastic modulus of 2.53GPa, and energyAbsorption we=0.5 is 62.1MJ/m 3 The energy absorption efficiency was 90%.
FIG. 5 is a TiNbZrTa spherical gradient porous part based on molecular sieve functional elements in example 4, with a rod diameter ranging from 410 μm to 712 μm, a yield strength of 73.9MPa, an elastic modulus of 2.50GPa, and an energy absorption We=0.5 of 60.4MJ/m 3 The energy absorption efficiency was 87%.
Fig. 6 is a pure Ti acetabular cup prosthesis based on molecular sieve functional motifs in example 5 of the invention. Wherein, (a) is a molecular sieve functional element with the porosity of 70% after optimization; (b) For the additive manufacturing, the yield strength of the porous part based on molecular sieve functional elements is 77.5MPa, the elastic modulus is 2.77GPa, and the energy absorption We=0.5 is 65.5MJ/m 3 The mass absorption efficiency was 80%; (c) Shaped acetabular cup prostheses based on molecular sieve functional motifs are prepared for additive manufacturing.
Fig. 7 is a TiNbZrTa femoral stem prosthesis based on molecular sieve functional motifs in example 8 of the present invention. Wherein, (a) is a molecular sieve functional element with the optimized porosity of 60%; (b) For the additive manufacturing, the yield strength of the porous part based on molecular sieve functional elements is 102.9MPa, the elastic modulus is 3.56GPa, and the energy absorption We=0.5 is 90.1MJ/m 3 The energy absorption efficiency is 85%; (c) Shaped femoral stem prostheses based on molecular sieve functional motifs are prepared for additive manufacturing.
Detailed Description
The present invention will be described in further detail with reference to examples and drawings, but embodiments of the present invention are not limited thereto.
The specific conditions are not noted in the examples of the present invention, and are carried out according to conventional conditions or conditions suggested by the manufacturer. The raw materials, reagents, etc. used, which are not noted to the manufacturer, are conventional products commercially available.
Example 1: (pure Ti linear gradient porous parts based on molecular sieve functional motifs, as shown in FIG. 2)
(1) Building molecular sieve functional motifs: selecting a molecular sieve unit with central symmetry characteristic representing the integral porous structure characteristic of the molecular sieve, drawing a molecular sieve unit pore parameter design domain according to the constraint of biological cell function requirements (unit size is 3-4 mm, porosity is 60% -90%; pore diameter range is 200-1200 μm) and additive manufacturing process limitation (pore diameter range is 200-1000 μm), and determining various pore parameters of the molecular sieve unit according to the parameter design domain, wherein the unit size is 3.5mm, the porosity is 70%, the pore diameter is 784 μm, the pore diameter is 572 μm and the pore diameter is 552 μm; reconstructing a physical model of the molecular sieve unit according to each confirmed pore parameter by adopting CAD modeling software SolidWorks to construct a molecular sieve functional element;
(2) Designing a molecular sieve gradient porous structure: designing a molecular sieve functional element into a linear gradient porous structure with a corresponding smooth transition change of the rod diameter by adopting a gradient porous design software Grasshopper platform, wherein the porosity is 70%, the rod diameter change range is 364-748 mu m, and the rod diameter change direction is gradually thickened from bottom to top, so as to construct the molecular sieve functional element with the gradient porous structure;
(3) Additive manufacturing, forming and preparing: after the molecular sieve functional primitive STL format of the gradient porous structure is imported into Materialise Magics for model repair, label creation and support, the STL model is imported into laser selective area melting EOS M280 equipment for printing and forming after being sliced by RP-Tools software, wherein the parameters are 160W of laser power, 1200mm/s of scanning speed, 60mm of laser scanning interval and 30mm of layer thickness. The powder material is medical pure Ti powder with the particle size of 15-53 mu m, and is dried at 60 ℃ before printing, and the preheating temperature of the substrate is 200 ℃. Cutting from a substrate by utilizing linear cutting after printing, cleaning for 1 hour in an ultrasonic cleaner by using a mixed solution of acetone, 2-propanol, hydrofluoric acid and ultrapure water (volume ratio is 1:1:1:7), drying for 10 hours in a baking oven at 40 ℃, heating for 1 hour in an inert atmosphere furnace at 1300 ℃, cooling along with the furnace, and carrying out sand blasting treatment by adopting alumina corundum with 220 meshes under 0.6MPa to obtain the gradient porous part.
Example 2: (NiTi axial gradient porous parts based on molecular sieve functional element, as shown in figure 3)
(1) Building molecular sieve functional motifs: selecting a unit model with central symmetry characteristic representing the integral porous structure characteristic of the molecular sieve, wherein the molecular sieve unit is constrained according to the functional requirement of biological cells (the unit size is 3-4 mm, the porosity is 60% -90%, the pore diameter range is 200-1200 mu m) and the additive manufacturing process limit (the rod diameter range is 200-1000 mu m), drawing a molecular sieve unit pore parameter design domain, and determining each pore parameter of the molecular sieve unit according to the parameter design domain, wherein the unit size is 3.5mm, the porosity is 70%, the large pore diameter is 784 mu m, the small pore diameter is 572 mu m and the rod diameter is 552 mu m; reconstructing a physical model of the molecular sieve unit according to each confirmed pore parameter by adopting CAD modeling software SolidWorks to construct a molecular sieve functional element;
(2) Designing a molecular sieve gradient porous structure: adopting a gradient porous design software Grasshopper platform to design the molecular sieve functional element into a linear gradient porous structure with a corresponding smooth transition change of the rod diameter, wherein the porosity is 70%, the range of the rod diameter change is 364-748 mu m, the rod diameter change direction is a central line in the height direction as a reference axis, and the rod diameters are respectively and gradually thickened upwards and downwards to construct the molecular sieve functional element with the gradient porous structure;
(3) Additive manufacturing, forming and preparing: after the molecular sieve functional primitive STL format of the gradient porous structure is imported into Materialise Magics for model repair, label creation and support, the STL model is imported into laser selective area melting EOS M280 equipment for printing and forming after being sliced by RP-Tools software, wherein the parameters are that the laser power is 200W, the scanning speed is 2000mm/s, the laser scanning interval is 80mm, and the layer thickness is 30mm. The powder material is NiTi alloy powder with the particle size of 15-53 μm, and is dried at 60 ℃ before printing, and the preheating temperature of the substrate is 200 ℃. Cutting from a substrate by utilizing linear cutting after printing, cleaning for 1 hour in an ultrasonic cleaner by using a mixed solution of acetone, 2-propanol, hydrofluoric acid and ultrapure water (volume ratio is 1:1:1:7), drying for 10 hours in a baking oven at 40 ℃, heating for 1 hour in an inert atmosphere furnace at 1300 ℃, cooling along with the furnace, and carrying out sand blasting treatment by adopting alumina corundum with 220 meshes under 0.6MPa to obtain the gradient porous part.
Example 3: (TiNbZrTa cylindrical gradient porous part based on molecular sieve functional element, as shown in figure 4)
(1) Building molecular sieve functional motifs: selecting a unit model with central symmetry characteristic representing the integral porous structure characteristic of the molecular sieve, wherein the molecular sieve unit is constrained according to the functional requirement of biological cells (the unit size is 3-4 mm, the porosity is 60% -90%, the pore diameter range is 200-1200 mu m) and the additive manufacturing process limit (the rod diameter range is 200-1000 mu m), drawing a molecular sieve unit pore parameter design domain, and determining each pore parameter of the molecular sieve unit according to the parameter design domain, wherein the unit size is 3.5mm, the porosity is 70%, the large pore diameter is 784 mu m, the small pore diameter is 572 mu m and the rod diameter is 552 mu m; reconstructing a physical model of the molecular sieve unit according to each confirmed pore parameter by adopting CAD modeling software SolidWorks to construct a molecular sieve functional element;
(2) Designing a molecular sieve gradient porous structure: adopting a gradient porous design software Grasshopper platform to design the molecular sieve functional element into a linear gradient porous structure with a corresponding smooth transition change of the rod diameter, wherein the porosity is 70%, the change range of the rod diameter is 394-712 μm, the change direction of the rod diameter is that the rod diameter is gradually thickened along the radial direction of a cylinder by taking a central point as the circle center, and the molecular sieve functional element with the gradient porous structure is constructed;
(3) Additive manufacturing, forming and preparing: after the molecular sieve functional primitive STL format of the gradient porous structure is imported into Materialise Magics for model repair, label creation and support, the STL model is imported into laser selective area melting EOS M280 equipment for printing and forming after being sliced by RP-Tools software, wherein the parameters are 160W of laser power, 1600mm/s of scanning speed, 60mm of laser scanning interval and 30mm of layer thickness. The powder material is TiNbZrTa alloy powder with the particle size of 15-53 mu m, and is dried at 60 ℃ before printing, and the preheating temperature of the substrate is 200 ℃. Cutting from a substrate by utilizing linear cutting after printing, cleaning for 1 hour in an ultrasonic cleaner by using a mixed solution of acetone, 2-propanol, hydrofluoric acid and ultrapure water (volume ratio is 1:1:1:7), drying for 10 hours in a baking oven at 40 ℃, heating for 1 hour in an inert atmosphere furnace at 1300 ℃, cooling along with the furnace, and carrying out sand blasting treatment by adopting alumina corundum with 220 meshes under 0.6MPa to obtain the gradient porous part.
Example 4: (TiNbZrTa spherical gradient porous parts based on molecular sieve functional elements, as shown in FIG. 5)
(1) Building molecular sieve functional motifs: selecting a unit model with central symmetry characteristic representing the integral porous structure characteristic of the molecular sieve, wherein the molecular sieve unit is constrained according to the functional requirement of biological cells (the unit size is 3-4 mm, the porosity is 60% -90%, the pore diameter range is 200-1200 mu m) and the additive manufacturing process limit (the rod diameter range is 200-1000 mu m), drawing a molecular sieve unit pore parameter design domain, and determining each pore parameter of the molecular sieve unit according to the parameter design domain, wherein the unit size is 3.5mm, the porosity is 70%, the large pore diameter is 784 mu m, the small pore diameter is 572 mu m, and the rod diameter range is 552 mu m; reconstructing a physical model of the molecular sieve unit according to each confirmed pore parameter by adopting CAD modeling software SolidWorks to construct a molecular sieve functional element;
(2) Designing a molecular sieve gradient porous structure: the gradient porous design software Grasshopper platform molecular sieve functional element is adopted to design a corresponding linear gradient porous structure with smooth transition change of the rod diameter, the porosity is 70%, the range of the rod diameter change is 410-712 μm, the rod diameter change direction is that the center point is used as the center of a circle, and the rod diameter is gradually thickened along the radial direction of the sphere, so that the molecular sieve functional element with the gradient porous structure is constructed;
(3) Additive manufacturing, forming and preparing: after the molecular sieve functional primitive STL format of the gradient porous structure is imported into Materialise Magics for model repair, label creation and support, the STL model is imported into laser selective area melting EOS M280 equipment for printing and forming after being sliced by RP-Tools software, wherein the parameters are 160W of laser power, 1600mm/s of scanning speed, 60mm of laser scanning interval and 30mm of layer thickness. The powder material is TiNbZrTa alloy powder with the particle size of 15-53 mu m, and is dried at 60 ℃ before printing, and the preheating temperature of the substrate is 200 ℃. Cutting from a substrate by utilizing linear cutting after printing, cleaning for 1 hour in an ultrasonic cleaner by using a mixed solution of acetone, 2-propanol, hydrofluoric acid and ultrapure water (volume ratio is 1:1:1:7), drying for 10 hours in a baking oven at 40 ℃, heating for 1 hour in an inert atmosphere furnace at 1300 ℃, cooling along with the furnace, and carrying out sand blasting treatment by adopting alumina corundum with 220 meshes under 0.6MPa to obtain the gradient porous part.
Example 5: (pure Ti porous acetabular cup prosthesis based on molecular sieve functional motifs, as shown in FIG. 6)
(1) Building molecular sieve functional motifs: selecting a unit model with central symmetry characteristic representing the integral porous structure characteristic of the molecular sieve, a molecular sieve unit, drawing a molecular sieve unit pore parameter design domain (namely drawing a pore diameter-rod diameter-porosity relation diagram) according to the constraint of biological cell function requirements (unit size is 3-4 mm, porosity is 60% -90%; pore diameter range is 200-1200 mu m) and additive manufacturing process limitation (rod diameter range is 200-1000 mu m), and determining each pore parameter of the molecular sieve unit according to the parameter design domain, wherein the unit size is 3.0mm, the porosity is 60%, the large pore diameter is 588 mu m, the small pore diameter is 406 mu m and the rod diameter is 560 mu m; reconstructing a physical model of the molecular sieve unit according to each confirmed pore parameter by adopting CAD modeling software SolidWorks to construct a molecular sieve functional element;
(2) The molecular sieve functional element is integrated with the implant prosthesis model and output: generating an acetabular cup prosthesis model in the Rhino software, inputting molecular sieve functional primitives into the Rhino software to serve as a basic unit model, filling porous areas of the acetabular cup prosthesis model with the molecular sieve functional primitives, and finally generating a corresponding molecular sieve porous acetabular cup prosthesis model;
(3) Additive manufacturing, forming and preparing: after the STL format of the porous prosthesis model is imported into Materialise Magics for model repair, label creation and support, the STL model is imported into laser selective area melting EOS M280 equipment for printing and forming after being sliced by RP-Tools software, wherein the parameters are that the laser power of a compact area is 200W, the scanning speed is 1000mm/s, the laser scanning interval is 60mm, the layer thickness is 30mm, the laser power of a porous area is 160W, the laser scanning speed is 1200mm/s, the laser scanning interval is 60mm, and the layer thickness is 30mm. The powder material is medical pure Ti powder with the particle size of 15-53 mu m, and is dried at 60 ℃ before printing, and the preheating temperature of the substrate is 200 ℃. Cutting from a substrate by utilizing linear cutting after printing, cleaning the substrate for 1 hour by using a mixed solution of acetone, 2-propanol, hydrofluoric acid and ultrapure water (volume ratio is 1:1:1:7), drying the substrate for 10 hours in a baking oven at 40 ℃, heating the substrate for 1 hour in an inert atmosphere furnace at 1300 ℃, cooling the substrate along with the furnace, and carrying out sand blasting treatment on the substrate by adopting alumina corundum with 220 meshes under 0.6MPa to obtain the final prosthesis.
Example 6: (NiTi porous acetabular cup prosthesis based on molecular sieve functional elements)
(1) Building molecular sieve functional motifs: selecting a unit model with central symmetry characteristic representing the integral porous structure characteristic of the molecular sieve, a molecular sieve unit, drawing a molecular sieve unit pore parameter design domain (namely drawing a pore diameter-rod diameter-porosity relation diagram) according to the constraint of biological cell function requirements (unit size is 3-4 mm, porosity is 60% -90%; pore diameter range is 200-1200 mu m) and additive manufacturing process limitation (rod diameter range is 200-1000 mu m), and determining each pore parameter of the molecular sieve unit according to the parameter design domain, wherein the unit size is 3.5mm, the porosity is 70%, the large pore diameter is 784 mu m, the small pore diameter is 572 mu m and the rod diameter is 552 mu m; reconstructing a physical model of the molecular sieve unit according to each confirmed pore parameter by adopting CAD modeling software SolidWorks to construct a molecular sieve functional element;
(2) The molecular sieve functional element is integrated with the implant prosthesis model and output: generating an acetabular cup prosthesis model in the Rhino software, inputting molecular sieve functional primitives into the Rhino software to serve as a basic unit model, filling porous areas of the acetabular cup prosthesis model with the molecular sieve functional primitives, and finally generating a corresponding molecular sieve porous acetabular cup prosthesis model;
(3) Additive manufacturing, forming and preparing: after the STL format of the porous prosthesis model is imported into Materialise Magics for model repair, label creation and support, the STL model is imported into laser selective area melting EOS M280 equipment for printing and forming after being sliced by RP-Tools software, wherein the parameters are that the laser power of a compact area is 200W, the scanning speed is 1000mm/s, the laser scanning interval is 80mm, the layer thickness is 30mm, the laser power of the porous area is 200W, the laser scanning speed is 2000mm/s, the laser scanning interval is 80mm, and the layer thickness is 30mm. The powder material is NiTi alloy powder with the particle size of 15-53 μm, and is dried at 60 ℃ before printing, and the preheating temperature of the substrate is 200 ℃. Cutting from a substrate by utilizing linear cutting after printing, cleaning the substrate for 1 hour by using a mixed solution of acetone, 2-propanol, hydrofluoric acid and ultrapure water (volume ratio is 1:1:1:7), drying the substrate for 10 hours in a baking oven at 40 ℃, heating the substrate for 1 hour in an inert atmosphere furnace at 1300 ℃, cooling the substrate along with the furnace, and carrying out sand blasting treatment on the substrate by adopting alumina corundum with 220 meshes under 0.6MPa to obtain the final prosthesis.
Example 7: (TiNbZrTa porous femoral stem prosthesis based on molecular sieve functional elements, as shown in figure 6)
(1) Building molecular sieve functional motifs: selecting a unit model with central symmetry characteristic representing the integral porous structure characteristic of the molecular sieve, a molecular sieve unit, drawing a molecular sieve unit pore parameter design domain (namely drawing a pore diameter-rod diameter-porosity relation diagram) according to the functional requirements of biological cells (the unit size is 3-4 mm, the porosity is 60% -90%, the pore diameter range is 200-1200 mu m) and the constraint of additive manufacturing process (the rod diameter range is 200-1000 mu m), and determining each pore parameter of the molecular sieve unit according to the parameter design domain, wherein the unit size is 3.5mm, the porosity is 80%, the large pore diameter is 899 mu m, the small pore diameter is 685 mu m and the rod diameter is 436 mu m; reconstructing a physical model of the molecular sieve unit according to each confirmed pore parameter by adopting CAD modeling software SolidWorks to construct a molecular sieve functional element;
(2) The molecular sieve functional element is integrated with the implant prosthesis model and output: generating molecular sieve functional elements of the acetabular cup prosthesis model in the Rhino software, inputting the molecular sieve functional elements into the Rhino software as a basic unit model, filling porous areas of the acetabular cup prosthesis model with the molecular sieve functional elements, and finally generating a corresponding molecular sieve porous femoral stem prosthesis model;
(3) Additive manufacturing, forming and preparing: after the STL format of the porous prosthesis model is imported into Materialise Magics for model repair, label creation and support, the STL model is imported into laser selective area melting EOS M280 equipment for printing and forming after being sliced by RP-Tools software, wherein the parameters are that the laser power of a compact area is 240W, the scanning speed is 1200mm/s, the laser scanning interval is 60mm, the layer thickness is 30mm, the laser power of a porous area is 160W, the laser scanning speed is 1600mm/s, the laser scanning interval is 60mm, and the layer thickness is 30mm. The powder material is TiNbZrTa alloy powder with the particle size of 15-53 mu m, and is dried at 60 ℃ before printing, and the preheating temperature of the substrate is 200 ℃. Cutting from a substrate by utilizing linear cutting after printing, cleaning the substrate for 1 hour by using a mixed solution of acetone, 2-propanol, hydrofluoric acid and ultrapure water (volume ratio is 1:1:1:7), drying the substrate for 10 hours in a baking oven at 40 ℃, heating the substrate for 1 hour in an inert atmosphere furnace at 1300 ℃, cooling the substrate along with the furnace, and carrying out sand blasting treatment on the substrate by adopting alumina corundum with 220 meshes under 0.6MPa to obtain the final prosthesis.
Example 8: (TiNbZrTa porous femoral stem prosthesis based on molecular sieve functional element)
(1) Building molecular sieve functional motifs: selecting a unit model with central symmetry characteristic representing the integral porous structure characteristic of the molecular sieve, a molecular sieve unit, drawing a molecular sieve unit pore parameter design domain (namely drawing a pore diameter-rod diameter-porosity relation diagram) according to the constraint of biological cell function requirements (the unit size is 3-4 mm, the porosity is 60% -90%, the pore diameter range is 200-1200 mu m) and additive manufacturing process limitations (the rod diameter range is 200-1000 mu m), and determining each pore parameter of the molecular sieve unit according to the parameter design domain, wherein the unit size is 4.0mm, the porosity is 90%, the large pore diameter is 1195 mu m, the small pore diameter is 952 mu m and the rod diameter is 332 mu m; reconstructing a physical model of the molecular sieve unit according to each confirmed pore parameter by adopting CAD modeling software SolidWorks to construct a molecular sieve functional element;
(2) The molecular sieve functional element is integrated with the implant prosthesis model and output: generating an acetabular cup prosthesis model in the Rhino software, inputting molecular sieve functional primitives into the Rhino software to serve as a basic unit model, filling porous areas of the acetabular cup prosthesis model with the molecular sieve functional primitives, and finally generating a corresponding molecular sieve porous femoral stem prosthesis model;
(3) Additive manufacturing, forming and preparing: after the STL format of the porous prosthesis model is imported into Materialise Magics for model repair, label creation and support, the STL model is imported into laser selective area melting EOS M280 equipment for printing and forming after being sliced by RP-Tools software, wherein the parameters are that the laser power of a compact area is 240W, the scanning speed is 1200mm/s, the laser scanning interval is 60mm, the layer thickness is 30mm, the laser power of a porous area is 160W, the laser scanning speed is 1600mm/s, the laser scanning interval is 60mm, and the layer thickness is 30mm. The powder material is TiNbZrTa alloy powder with the particle size of 15-53 mu m, and is dried at 60 ℃ before printing, and the preheating temperature of the substrate is 200 ℃. Cutting from a substrate by utilizing linear cutting after printing, cleaning the substrate for 1 hour by using a mixed solution of acetone, 2-propanol, hydrofluoric acid and ultrapure water (volume ratio is 1:1:1:7), drying the substrate for 10 hours in a baking oven at 40 ℃, heating the substrate for 1 hour in an inert atmosphere furnace at 1300 ℃, cooling the substrate along with the furnace, and carrying out sand blasting treatment on the substrate by adopting alumina corundum with 220 meshes under 0.6MPa to obtain the final prosthesis.
The above examples are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above examples, and any other changes, modifications, substitutions, combinations, and simplifications that do not depart from the spirit and principle of the present invention should be made in the equivalent manner, and the embodiments are included in the protection scope of the present invention.
Claims (10)
1. A method for preparing a medical implant based on molecular sieve functional motifs, comprising the steps of:
(1) Building molecular sieve functional motifs: selecting a molecular sieve unit with central symmetry characteristic representing the integral porous structure characteristic of the molecular sieve, drawing a pore parameter design domain of the molecular sieve unit according to the biological cell function requirement and the additive manufacturing process limit constraint, determining each pore parameter of the molecular sieve unit according to the parameter design domain, and carrying out physical model reconstruction on the molecular sieve unit by modeling software to construct a molecular sieve functional element;
(2) Designing a molecular sieve gradient porous structure: designing the molecular sieve functional element structure in the step (1) into a gradient porous structure corresponding to the smooth transition change of the rod diameter, and constructing the molecular sieve functional element of the gradient porous structure;
(3) And integrating and outputting the molecular sieve functional element and the implant prosthesis model: generating an implant prosthesis model in software, inputting the molecular sieve functional element in the step (1) or the molecular sieve functional element in the step (2) with the gradient porous structure into the software as a basic unit model for filling corresponding parts of the implant prosthesis model, and generating a porous implant prosthesis model;
(4) Additive manufacturing, forming and preparing: and (3) repairing the part model of the molecular sieve functional element in the step (1) or the molecular sieve functional element in the step (2) or the porous implant prosthesis model in the step (3) by using software, introducing the part model into additive manufacturing equipment for customized partition printing and forming after slicing treatment, and obtaining the medical implant solid part or prosthesis through post treatment.
2. The method of claim 1, wherein the biological cell function requirement in step (1) is specifically: the range of pore parameter values comprises the unit size of 3 mm-4 mm and the porosity of 60-90%; the aperture range is 200-1200 mu m; the additive manufacturing process limitations are specifically: the diameter range of the rod is 200-1000 μm; the pore parameters include porosity, pore diameter, rod diameter and unit size;
the pore parameter design domain in the step (1) specifically comprises: the pore diameter of 200-1200 mu m, the porosity of 60-90% and the rod diameter of 200-1000 mu m are used as constraint conditions to draw the pore parameter design domain of the molecular sieve functional element.
3. The method for preparing a medical implant based on molecular sieve functional elements according to claim 1, wherein the physical model reconstruction process of the molecular sieve functional elements in the step (1) is as follows: simplifying each strut in a molecular sieve unit into a line, drawing a line diagram of the molecular sieve unit in software, and then rotating for one circle with a specified radius by taking each line diagram as a central axis and materializing to obtain a molecular sieve functional primitive; the specified radius is half of the diameter of the rod.
4. The method of claim 1, wherein the customized zoned printing in step (4) is performed as follows: the compact area and the porous area of the medical implant are formed by partition printing through adjusting technological parameters, specifically, the laser power range of the compact area is 200-240W, the laser scanning speed range is 1000-1200 mm/s, the laser scanning interval range is 60-80 mm, and the layer thickness range is 30-50 mm; the laser power range of the porous area is 160-200W, the laser scanning speed range is 1200-2000 mm/s, the laser scanning interval range is 60-80 mm, and the layer thickness range is 30-45 mm.
5. The method for preparing a medical implant based on molecular sieve functional elements according to claim 1, wherein the gradient porous structure with smooth transition change of the corresponding rod diameter in the step (2) refers to a gradient porous structure with smooth transition change of the corresponding rod diameter in the range of 200-1000 μm.
6. The method of claim 1, wherein the modeling software in step (1) is CAD modeling software SolidWorks;
in the step (2), a gradient porous structure design of the molecular sieve adopts a gradient porous design software Grasshopper platform; the software in the step (3) is Rhino;
the software for model restoration and slicing in step (4) was Materialise Magics and RP-Tools, respectively.
7. The method of claim 1, wherein in step (3), the filling corresponding portion refers to a porous implant prosthesis divided into a dense region and a porous region, and the porous region is filled with the molecular sieve functional element.
8. The method for preparing a medical implant based on molecular sieve functional elements according to claim 1, wherein the medical metal material used in the additive manufacturing in the step (4) is at least one of medical pure titanium, medical TC4, ti-Nb-based medical beta titanium alloy, ti-Mo-based medical beta titanium alloy, ti-Zr-based medical beta titanium alloy, ti-Nb-Hf-based medical beta titanium alloy, ti-Nb-Zr-based medical beta titanium alloy, niTi-based shape memory alloy, coCr-based alloy and medical stainless steel;
the additive manufacturing equipment in the step (4) is one of CONCEPT LASER M2, EOS M280/290, SLMsolution 125/250/280.0/500, RENISHAW 400, BLT-S320, arcam A2x, arcam Q20, QEBAM Lab200 and Qbeam 3D.
9. A medical implant based on molecular sieve functional motifs made by the method of any one of claims 1 to 8.
10. The molecular sieve functional primitive-based medical implant of claim 9, wherein the implant comprises one of a joint implant, a spinal implant, a shoulder implant, a craniomaxillofacial implant, an ankle implant, a sternum implant, and a toe bone implant;
the joint implant is a hip and knee joint implant, the spine implant is an internal fixation spine implant and a minimally invasive spine implant, the shoulder implant is a scapula implant, the craniomaxillofacial implant is a mandibular implant and a skull implant, and the ankle implant is a ankle implant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210508554.7A CN115090903B (en) | 2022-05-11 | 2022-05-11 | Medical implant based on molecular sieve functional element and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210508554.7A CN115090903B (en) | 2022-05-11 | 2022-05-11 | Medical implant based on molecular sieve functional element and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115090903A CN115090903A (en) | 2022-09-23 |
| CN115090903B true CN115090903B (en) | 2023-04-21 |
Family
ID=83287843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210508554.7A Active CN115090903B (en) | 2022-05-11 | 2022-05-11 | Medical implant based on molecular sieve functional element and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115090903B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115958203B (en) * | 2022-10-19 | 2023-06-20 | 中国机械总院集团沈阳铸造研究所有限公司 | Variable density lattice metal with vibration reduction characteristic |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100588379C (en) * | 2008-06-26 | 2010-02-10 | 上海交通大学 | Preparation of artificial joint prosthesis with partially controllable porous structure |
| CN105479585B (en) * | 2015-11-25 | 2017-08-25 | 山东理工大学 | The method that 3 D-printing prepares the honeycomb type ceramic film component with stereo channel |
| US10647580B2 (en) * | 2017-01-26 | 2020-05-12 | Lawrence Livermore National Security, Llc | Three-dimensional deterministic graphene architectures formed using three-dimensional templates |
| CN109160800A (en) * | 2018-10-08 | 2019-01-08 | 吉林大学 | A method of monoblock type molecular sieve block is prepared based on 3D printing technique |
| CN112222409B (en) * | 2020-09-23 | 2021-08-10 | 华南理工大学 | Additive manufacturing method for customizing elastic modulus of medical titanium alloy implant and application |
| CN112966411B (en) * | 2021-02-07 | 2022-05-24 | 华南理工大学 | Medical implant based on body representative unit stress and preparation method and application thereof |
-
2022
- 2022-05-11 CN CN202210508554.7A patent/CN115090903B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN115090903A (en) | 2022-09-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Ran et al. | Osteogenesis of 3D printed porous Ti6Al4V implants with different pore sizes | |
| Aufa et al. | Recent advances in Ti-6Al-4V additively manufactured by selective laser melting for biomedical implants: Prospect development | |
| Pei et al. | 3D printed titanium scaffolds with homogeneous diamond-like structures mimicking that of the osteocyte microenvironment and its bone regeneration study | |
| Han et al. | Porous tantalum and titanium in orthopedics: a review | |
| Tan et al. | Metallic powder-bed based 3D printing of cellular scaffolds for orthopaedic implants: A state-of-the-art review on manufacturing, topological design, mechanical properties and biocompatibility | |
| Feng et al. | Application of 3D printing technology in bone tissue engineering: a review | |
| Gao et al. | Additive manufacturing technique-designed metallic porous implants for clinical application in orthopedics | |
| CN105662621B (en) | A kind of porous dental implant and its manufacturing method of drug-carrying slow-released system | |
| Warnke et al. | Rapid prototyping: porous titanium alloy scaffolds produced by selective laser melting for bone tissue engineering | |
| CN103328016B (en) | Implant for in-vivo insertion which is formed with a porous coating layer thereon | |
| CN204581484U (en) | A kind of 3D with three-dimensional through loose structure prints bone screw | |
| Raheem et al. | A review on development of bio-inspired implants using 3D printing | |
| Dziaduszewska et al. | Structural and material determinants influencing the behavior of porous Ti and its alloys made by additive manufacturing techniques for biomedical applications | |
| CN112966411B (en) | Medical implant based on body representative unit stress and preparation method and application thereof | |
| Wang et al. | Biomimetic design strategy of complex porous structure based on 3D printing Ti-6Al-4V scaffolds for enhanced osseointegration | |
| CN109771105B (en) | 3D prints porous tantalum interbody fusion cage | |
| CN205698065U (en) | The porous tooth implant of drug-carrying slow-released system | |
| CN104758042A (en) | Bone screw of three-dimensional through porous structure | |
| CN112076009A (en) | Multilayer bionic joint based on curved surface 3D printing and preparation method thereof | |
| CN115090903B (en) | Medical implant based on molecular sieve functional element and preparation method thereof | |
| CN115634311A (en) | Multi-structure cartilage repair implant and preparation method thereof | |
| CN111728741A (en) | Human body personalized hip joint femoral stem prosthesis adopting lightweight design and manufacturing method thereof | |
| CN107397977B (en) | 3D printing metal matrix surface modification method, 3D printing metal matrix biological ceramic support and preparation method thereof | |
| CN205903333U (en) | 3D prints imitative porous bearing metal false body of bone trabecula | |
| CN104758982B (en) | A kind of personalized β Ti 15Mo alloys Co 28Cr 6Mo alloy Al2O3Ceramic cotyloid cavities artificial bone scaffold |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |