CN109745240A - A kind of creams and preparation method thereof containing glycyrrhetinic acid - Google Patents
A kind of creams and preparation method thereof containing glycyrrhetinic acid Download PDFInfo
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Abstract
The invention belongs to technical field of fine, it is related to a kind of creams and preparation method thereof containing glycyrrhetinic acid, including water phase, oily phase, low-temperature phase 1 and low-temperature phase 2, it include glycyrrhetinic acid in low-temperature phase 1, preparation method is water phase, oil is mutually separately heated to 75-80 DEG C, and gradient homogeneous obtains O/W emulsion, low-temperature phase 1 is pre-processed, glycyrrhetinic acid polyalcohol dissolution is evenly dispersed, is added in 46-65 DEG C, low-temperature phase 2 is added in 42-45 DEG C.One kind of the invention contains that glycyrrhetinic acid creams are highly-safe, effect is good, can be used for the nursing of inflammation, allergy and sensitive skin.Water phase and oil mutually pass through gradient homogeneous in preparation method, and obtained O/W emulsion particle diameter is smaller, more evenly, have higher stability after tying cream；By being pre-processed to glycyrrhetinic acid, enoxolone dispersion can be made more evenly, and can effectively prevent its recrystallization in creams, it is made preferably to play effect.
Description
Technical field
The invention belongs to technical field of fine, it is related to a kind of skin care item and preparation method thereof, specially one kind contains
Creams of glycyrrhetinic acid and preparation method thereof.
Background technique
The chemical structure of glycyrrhetinic acid is similar to steroid hormone, is the 11 beta-hydroxy steroidal dehydrogenation of steroid hormone metabolic inactivation enzyme
The inhibitor of enzyme.The 11 beta-hydroxy steroid dehydrogenase type activity of inhibition of glycyrrhetinic acid correlation, it is thin that regulation glucocorticoid enters target
The activity of endogenous and exogenous glucocorticoid can be improved, but also as ligand and glucocorticoid in born of the same parents' cortical hormone receptor
Receptor combines, and is sugared cortical hormone since the glucocorticoid receptor agonist activity of glycyrrhetinic acid is far below glucocorticoid
The partial agonist antagonist of plain receptor.Clinically can not only it enhance using glycyrrhetinic acid as weak glucocorticoid sample medicinal application
The effect of glucocorticoid, and the adverse reaction of antagonism high dose glucocorticoid, while dependence will not be formed.It is sweet simultaneously
Careless pavilion acid is by selectively inhibiting metabolic enzyme-phosphide enzyme A 2 and lipoxygenase with arachidonic acid generation cascade reaction
Activity complete, so that the inflammatory mediators such as prostaglandin, leukotriene can not generate, and inhibit the synthesis of prostaglandin and release
It puts, to generate anti-inflammatory effect.
The above mechanism of action based on glycyrrhetinic acid can develop a kind of anti-inflammatory, antiallergic sense the skin care item of glycyrrhetinic acid.
And since glycyrrhetinic acid is not soluble in water, it is also insoluble in oil, there is the risk of recrystallization again in lotion.Glycyrrhetinic acid is used at present
Skin care item it is seldom, mostly using the carboxylate of glycyrrhetate or glycyrrhetinic acid, the effect of antiallergy and verifying is not so good as sweet
Careless pavilion acid.The domestic glycyrrhetinic acid raw material that also can be used directly at present without pretreatment.Have in commercially available product using glycyrrhetin
Whether the acid of dispersibility to(for) glycyrrhetinic acid and is precipitated because Essence is adsorbed on film towel and for disposable product
It is required that lower.Therefore adding technology of the glycyrrhetinic acid in creams class product is a technical problem.
Summary of the invention
One of the objects of the present invention is to provide one kind to contain glycyrrhetinic acid creams, can be used for inflammation, allergy or sensitivity
The nursing of skin；
The second object of the present invention is to provide a kind of preparation method containing glycyrrhetinic acid creams, and glycyrrhetinic acid is overcome to be difficult to add
The technical problem being added in creams system.
The technical scheme is that a kind of contain glycyrrhetinic acid lotion, successively include following ingredient by weight:
Oily phase:
The smooth olive oleate 0.5-3.0% of sorb
Cetearyl glucoside 0.5-3.0%
Cetostearyl alcohol 2.0-6.0%
Beeswax 1.0-3.0%
Butyrospermum parkii fruit rouge 1.0-5.0%
Parleam 1.0-4.0%
Dimethicone 2.0-5.0%
Ring five dimethyl silicone polymer 1.0-3.0%
Caprylic/capric triglyceride 2.0-8.0%
Water phase:
Water 60-80%
Polyalcohol 0-5.0%
Allantoin 0.2-0.6%
Methyl hydroxybenzoate 0.1-0.2%
Xanthan gum 0.01-0.2%
Low-temperature phase 1:
Polyalcohol 1.0-6.0%
Glycyrrhetinic acid 0.1-0.5%
Low-temperature phase 2:
Panthenol 0.1-1.5%
Herba polygoni hydropiperis extract 0.01-0.1%
Phenoxyethanol 0.5-0.8%
Sensiva SC50 0.05-0.1%
A kind of above-mentioned creams containing glycyrrhetinic acid, the polyalcohol can be ethyl alcohol, glycerol, propylene glycol, butanediol, 1,2-
One of pentanediol is a variety of, and the ethyl alcohol is full gear alcohol or denatured ethyl alcohol.
A kind of preparation method of the creams containing glycyrrhetinic acid, in turn includes the following steps:
Step 1) sequentially adds each raw material of water phase, is added after wherein xanthan gum is dispersed with glycerol, 300-400r/min agitating and heating
To being completely dissolved, it is warming up to 75-80 DEG C, keeps the temperature 20-30min；
Step 2 sequentially adds mutually each raw material of oil, and 300-400r/min is heated with stirring to complete melting, is warming up to 75-80 DEG C, protects
Warm 20-30min；
Step 3) low-temperature phase 1 pre-processes, glycyrrhetinic acid polyalcohol dissolution or evenly dispersed；
Step 4) temperature is kept for 75-80 DEG C, during the oil phase is added to the aqueous phase, and gradient homogeneous obtains uniform emulsion；
Emulsion 35-50r/min obtained stirring is cooled to 46-65 DEG C in step 5) step 4), and low-temperature phase Isosorbide-5-Nitrae 5-60r/ is added
After min stirs 5-10min, homogeneous keeps low-temperature phase 1 evenly dispersed；
Emulsion 35-50r/min obtained stirring is cooled to 42-45 DEG C in step 6) step 4), and low-temperature phase 2,45-60r/ is added
After min stirs 5-10min, homogeneous keeps low-temperature phase 2 evenly dispersed, continues to stir 15-30min with 45-60r/min；
Step 7) is cooled to 35 DEG C hereinafter, obtaining finished product.
A kind of preparation method of above-mentioned creams containing glycyrrhetinic acid, glycyrrhetinic acid polyalcohol described in step 3)
It is dissolved as glycyrrhetinic acid to be dissolved with 95% full gear alcohol, the weight ratio of the glycyrrhetinic acid and 95% full gear alcohol is 1:10.
Further, glycyrrhetinic acid described in step 3) is glycyrrhetinic acid propylene glycol or butanediol or penta with disperse polyol
Glycol dispersion, is evenly stirred until no agglomeration.
Further, gradient homogenization described in step 4) is speed of agitator 45-60r/min, and processing condition is
3000r/min homogeneous 2-5min, 3500r/min homogeneous 2-5min, 4000r/min homogeneous 5-10min.
Further, step 5), homogenization described in step 6) are speed of agitator 45-60r/min, and processing condition is
3000r/min homogeneous 2-5min.
Technical effect of the invention: one kind of the invention contains glycyrrhetinic acid creams, by providing a kind of highly-safe, function
The formula imitated is effectively relieved, controls, treats skin using having effects that glucocoricoid effect ingredient glycyrrhetinic acid
Inflammatory symptoms, while there is preferable antipruritic treatment can be used for hormone dependant for the nursing of inflammation, allergy and sensitive skin
The skin nursing of property dermatitis patients.
A kind of preparation method containing glycyrrhetinic acid creams of the invention has following technical advantage: (1) water phase and oil
Mutually pass through gradient homogeneous, obtained O/W emulsion particle diameter is smaller, more evenly, has higher stability, 45 DEG C of acceleration after tying cream
Stable state is still maintained after 3 months, no layering is without precipitation；(2) by pre-processing to glycyrrhetinic acid, glycyrrhetin is obtained
The polyhydric alcohol solutions or dispersion liquid of acid, are added under low temperature, and carry out second homogenate after emulsification, and enoxolone dispersion can be made more equal
It is even, and can effectively prevent its recrystallization in creams, so that it is preferably played effect.
Detailed description of the invention:
Fig. 1 is 40 times of electron microscopes for implementing products obtained therefrom in 10.
Fig. 2 is that patient A uses 13 weeks front and back comparison diagrams of product in embodiment 10
Specific embodiment:
Embodiment 1
One kind of the present embodiment contains glycyrrhetinic acid lotion, successively includes following ingredient by weight:
Oily phase:
The smooth olive oleate 0.5-3.0% of sorb
Cetearyl glucoside 0.5-3.0%
Cetostearyl alcohol 2.0-6.0%
Beeswax 1.0-3.0%
Butyrospermum parkii fruit rouge 1.0-5.0%
Parleam 1.0-4.0%
Dimethicone 2.0-5.0%
Ring five dimethyl silicone polymer 1.0-3.0%
Caprylic/capric triglyceride 2.0-8.0%
Water phase:
Water 60-80%
Polyalcohol 0-5.0%
Allantoin 0.2-0.6%
Methyl hydroxybenzoate 0.1-0.2%
Xanthan gum 0.01-0.2%
Low-temperature phase 1:
Polyalcohol 1.0-6.0%
Glycyrrhetinic acid 0.1-0.5%
Low-temperature phase 2:
Panthenol 0.1-1.5%
Herba polygoni hydropiperis extract 0.01-0.1%
Phenoxyethanol 0.5-0.8%
Sensiva SC50 0.05-0.1%
One kind of the present embodiment contains glycyrrhetinic acid creams, by providing a kind of formula highly-safe, effect is good, using having
Glucocoricoid act on the effect of ingredient glycyrrhetinic acid, be effectively relieved, control, treating cutaneous inflammatory conditions, at the same have compared with
Good antipruritic treatment can be used for the skin shield of steroid dependent dermatitis patient for the nursing of inflammation, allergy and sensitive skin
Reason.
Embodiment 2
On the basis of embodiment 1, the polyalcohol can be ethyl alcohol, glycerol, propylene glycol, butanediol, 1,2- penta to the present embodiment
One of glycol is a variety of, and the ethyl alcohol is full gear alcohol or denatured ethyl alcohol.
Embodiment 3
The present embodiment is on the basis of embodiment 1-2, as a preferred embodiment, a kind of contain glycyrrhetinic acid lotion,
By weight, successively include following ingredient:
Oily phase:
The smooth olive oleate 2.0% of sorb
Cetearyl glucoside 1.5%
Cetostearyl alcohol 4.0%
Beeswax 2.0%
Butyrospermum parkii fruit rouge 2.0%
Parleam 2.0%
Dimethicone 4.0%
Ring five dimethyl silicone polymer 1.5%
Caprylic/capric triglyceride 5.0%
Water phase:
Water 66.33%
Glycerol 2.0%
Butanediol 2.0%
Allantoin 0.3%
Methyl hydroxybenzoate 0.15%
Xanthan gum 0.1%
Low-temperature phase 1:
Ethyl alcohol 2.0%
Glycyrrhetinic acid 0.2%
Low-temperature phase 2:
Panthenol 1.0%
Herba polygoni hydropiperis extract 0.02%
Phenoxyethanol 0.72%
Sensiva SC50 0.08%
Embodiment 4
The present embodiment is on the basis of embodiment 1-2, as a preferred embodiment, a kind of contain glycyrrhetinic acid lotion,
By weight, successively include following ingredient:
Oily phase:
The smooth olive oleate 2.0% of sorb
Cetearyl glucoside 1.5%
Cetostearyl alcohol 4.0%
Beeswax 1.0%
Butyrospermum parkii fruit rouge 3.0%
Parleam 2.0%
Dimethicone 5.0%
Ring five dimethyl silicone polymer 1.0%
Caprylic/capric triglyceride 3.0%
Water phase:
Water 70.34%
Glycerol 3.0%
Allantoin 0.5%
Methyl hydroxybenzoate 0.1%
Xanthan gum 0.15%
Low-temperature phase 1: butanediol 2.0%
1,2- pentanediol 1.0%
Glycyrrhetinic acid 0.3%
Low-temperature phase 2:
Panthenol 0.5%
Herba polygoni hydropiperis extract 0.01%
Phenoxyethanol 0.54%
Sensiva SC50 0.06%
Embodiment 5
A kind of preparation method of creams containing glycyrrhetinic acid of embodiment 1-4, in turn includes the following steps:
Step 1) sequentially adds each raw material of water phase, is added after wherein xanthan gum is dispersed with glycerol, 300-400r/min agitating and heating
To being completely dissolved, it is warming up to 75-80 DEG C, keeps the temperature 20-30min；
Step 2 sequentially adds mutually each raw material of oil, and 300-400r/min is heated with stirring to complete melting, is warming up to 75-80 DEG C, protects
Warm 20-30min；
Step 3) low-temperature phase 1 pre-processes, glycyrrhetinic acid polyalcohol dissolution or evenly dispersed；
Step 4) temperature is kept for 75-80 DEG C, during the oil phase is added to the aqueous phase, and gradient homogeneous obtains uniform emulsion；
Emulsion 35-50r/min obtained stirring is cooled to 46-65 DEG C in step 5) step 4), and low-temperature phase Isosorbide-5-Nitrae 5-60r/ is added
After min stirs 5-10min, homogeneous keeps low-temperature phase 1 evenly dispersed；
Emulsion 35-50r/min obtained stirring is cooled to 42-45 DEG C in step 6) step 4), and low-temperature phase 2,45-60r/ is added
After min stirs 5-10min, homogeneous keeps low-temperature phase 2 evenly dispersed, continues to stir 15-30min with 45-60r/min；
Step 7) is cooled to 35 DEG C hereinafter, obtaining finished product.
Embodiment 6
The present embodiment is on the basis of embodiment 3, embodiment 5, as preferred embodiment, glycyrrhetin described in step 3)
Acid is dissolved as glycyrrhetinic acid with polyalcohol and is dissolved with 95% full gear alcohol, and the weight ratio of the glycyrrhetinic acid and 95% full gear alcohol is
1:10.
Glycyrrhetinic acid is not soluble in water, is also insoluble in oil, and the solubility in alcohol is about 10%, can be precipitated after alcohol volatilization, therefore
After glycyrrhetinic acid is completely dissolved with alcohol, lower than alcohol boiling point at a temperature of be added obtained by step 4) in emulsion, avoid
The crystallization of glycyrrhetinic acid caused by alcohol volatilizees is precipitated, as a preferred embodiment, being stirred in step 5) with 45r/min
After 10min, homogeneous keeps low-temperature phase 1 evenly dispersed；
Embodiment 7
The present embodiment is on the basis of embodiment 4, embodiment 5, as preferred embodiment, glycyrrhetin described in step 3)
Acid is that glycyrrhetinic acid propylene glycol or butanediol or pentanediol disperse with disperse polyol, is evenly stirred until no agglomeration.
As a preferred embodiment, glycyrrhetinic acid butanediol described in step 3) and pentanediol dispersion, are stirred
It mixes uniformly to no agglomeration.
Glycyrrhetinic acid can be evenly dispersed in polyalcohol, stands or keeps uniform dispersity when heating, as one
Kind of preferred embodiment, emulsion 35-50r/min stirring obtained is cooled to 55 DEG C in step 4), and low-temperature phase 1 is added,
After 60r/min stirs 5min, homogeneous keeps low-temperature phase 1 evenly dispersed.
Low-temperature phase 1 is pre-processed by way of embodiment 5-7, is being added to obtained by step 4) in the way of step 5)
Emulsion in, i.e., glycyrrhetinic acid is pre-processed, obtains the polyhydric alcohol solutions or dispersion liquid of glycyrrhetinic acid, it is low after emulsification
Temperature is lower to be added, and carries out second homogenate, can make enoxolone dispersion more evenly, and can effectively prevent its knot again in creams
Crystalline substance makes it preferably play effect.
Embodiment 8
The present embodiment is on the basis of embodiment 5-7, as preferred embodiment, homogeneous described in step 5), step 6)
Technique is speed of agitator 45-60r/min, and processing condition is 3000r/min homogeneous 2-5min.Embodiment party as one preferred
Formula, homogenization are speed of agitator 60r/min, and processing condition is 3000r/min homogeneous 3min.
Embodiment 9
The present embodiment is on the basis of embodiment 5-8, as preferred embodiment, gradient homogenization described in step 4)
For speed of agitator 45-60r/min, processing condition is 3000r/min homogeneous 2-5min, 3500r/min homogeneous 2-5min, 4000r/
Min homogeneous 5-10min.As a preferred embodiment, gradient homogenization described in step 4) is speed of agitator
45r/min, processing condition is 3000r/min homogeneous 2min, 3500r/min homogeneous 5min, 4000r/min homogeneous 8min, or is stirred
Revolving speed 50r/min is mixed, processing condition is 3000r/min homogeneous 3min, 3500r/min homogeneous 3min, 4000r/min homogeneous
10min。
A kind of preparation method containing glycyrrhetinic acid creams of the present embodiment, water phase and oil mutually pass through gradient homogeneous, obtain
O/W emulsion particle diameter it is smaller, more evenly, there is higher stability after tying cream.
Embodiment 10
A kind of creams containing enoxolone, ingredient are preparation process described in embodiment 4 are as follows:
Step 1) sequentially adds each raw material of water phase, is added after wherein xanthan gum is dispersed with glycerol, 300-400r/min agitating and heating
To being completely dissolved, 80 DEG C are warming up to, keeps the temperature 30min；
Step 2 sequentially adds mutually each raw material of oil, and 300r/min is heated with stirring to complete melting, is warming up to 80 DEG C, keeps the temperature 30min；
Step 3) low-temperature phase 1 pre-processes, and glycyrrhetinic acid butanediol and pentanediol dispersion are evenly stirred until no agglomeration；
Step 4) temperature is kept for 80 DEG C, during the oil phase is added to the aqueous phase, and gradient homogeneous, processing condition is speed of agitator 50r/min,
3000r/min homogeneous 3min, 3500r/min homogeneous 3min, 4000r/min homogeneous 10min obtains uniform emulsion；
Emulsion 50r/min obtained stirring is cooled to 60 DEG C in step 5) step 4), and low-temperature phase 1,50r/min stirring is added
After 5min, revolving speed 50r/min is kept, keeps low-temperature phase 1 evenly dispersed with 3000r/min homogeneous 3min；
Emulsion 50r/min obtained stirring is cooled to 45 DEG C in step 6) step 4), and low-temperature phase 2,50r/min stirring is added
After 10min, keep low-temperature phase 2 evenly dispersed with 3000r/min homogeneous 1min, continues to stir 20min with 50r/min；
Step 7) is cooled to 35 DEG C hereinafter, obtaining finished product.
Homogenizer used in embodiment 1-10 are as follows: the complete emulsifying device of Fu Luke, device model FISCO-10L.
The obtained creams containing glycyrrhetinic acid of the present embodiment, are observed under the microscope, and 40 times of enlarged drawings are such as
Shown in Fig. 1.
A kind of creams containing enoxolone of the present embodiment, have carried out stability, security test, result is as follows:
1 stability test result of table
2 security test result of table
A kind of skin care item for steroid dependent dermatitis skin nursing of the present embodiment, with preferable stability and higher
Human safety.
A kind of creams containing enoxolone of the present embodiment have carried out 500 person-times of the effect of property verifyings, have verified crowd's packet
Include steroid dependent dermatitis patient, skin is in scytitis caused by the crowd, easy allergic human population, other reasons of allergy phase
Crowd includes but is not limited to skin of face using position.Verification result is integrated with efficiency and is higher than 95%, trier's dermal inflammatory disease
Shape has different degrees of alleviation, improvement, until recovery from illness.
The patient A of therapy of facial hormone dependent dermatitis, 32 years old, sick time 1 year, face visible apparent erythema when going to a doctor,
Scratchiness is obvious, and VISIA skin diagnosis instrument detects red sector index 1%, and face uses a kind of containing enoxolone of the present embodiment
After creams 13 weeks (2015.4.27-2015.7.10), VISIA detection red sector index rises to 30% for 1%, and skin health degree is bright
It is aobvious to be promoted.In VISIA Testing index red sector index can indication skin inflammatory conditions, Testing index is higher, and it is lighter to represent inflammation,
Skin barrier function is better.Comparison diagram before and after its use as shown in Fig. 2, its facial erythema almost disappear, the colour of skin it is more equal
Even, visual skin condition is in good health.
Claims (6)
- Successively include following ingredient by weight 1. one kind contains glycyrrhetinic acid creams:Oily phase:The smooth olive oleate 0.5-3.0% of sorbCetearyl glucoside 0.5-3.0%Cetostearyl alcohol 2.0-6.0%Beeswax 1.0-3.0%Butyrospermum parkii fruit rouge 1.0-5.0%Parleam 1.0-4.0%Dimethicone 2.0-5.0%Ring five dimethyl silicone polymer 1.0-3.0%Caprylic/capric triglyceride 2.0-8.0%Water phase:Water 60-80%Polyalcohol 0-5.0%Allantoin 0.2-0.6%Methyl hydroxybenzoate 0.1-0.2%Xanthan gum 0.01-0.2%Low-temperature phase 1:Polyalcohol 1.0-6.0%Glycyrrhetinic acid 0.1-0.5%Low-temperature phase 2:Panthenol 0.1-1.5%Herba polygoni hydropiperis extract 0.01-0.1%Phenoxyethanol 0.5-0.8%Sensiva SC50 0.05-0.1%A kind of creams containing glycyrrhetinic acid as described in claim 1, it is characterised in that: the polyalcohol can for ethyl alcohol, One of glycerol, propylene glycol, butanediol, 1,2- pentanediol are a variety of, and the ethyl alcohol is full gear alcohol or denatured ethyl alcohol.
- 2. a kind of preparation method of the creams containing glycyrrhetinic acid, in turn includes the following steps:Step 1) sequentially adds each raw material of water phase, is added after wherein xanthan gum is dispersed with glycerol, 300-400r/min agitating and heating To being completely dissolved, it is warming up to 75-80 DEG C, keeps the temperature 20-30min；Step 2 sequentially adds mutually each raw material of oil, and 300-400r/min is heated with stirring to complete melting, is warming up to 75-80 DEG C, protects Warm 20-30min；Step 3) low-temperature phase 1 pre-processes, glycyrrhetinic acid polyalcohol dissolution or evenly dispersed；Step 4) temperature is kept for 75-80 DEG C, during the oil phase is added to the aqueous phase, and gradient homogeneous obtains uniform emulsion；Emulsion 35-50r/min obtained stirring is cooled to 46-65 DEG C in step 5) step 4), and low-temperature phase Isosorbide-5-Nitrae 5-60r/ is added After min stirs 5-10min, homogeneous keeps low-temperature phase 1 evenly dispersed；Emulsion 35-50r/min obtained stirring is cooled to 42-45 DEG C in step 6) step 4), and low-temperature phase 2,45-60r/ is added After min stirs 5-10min, homogeneous keeps low-temperature phase 2 evenly dispersed, continues to stir 15-30min with 45-60r/min；Step 7) is cooled to 35 DEG C hereinafter, obtaining finished product.
- 3. a kind of preparation method of the creams containing glycyrrhetinic acid as claimed in claim 3, it is characterised in that: institute in step 3) The glycyrrhetinic acid stated is dissolved as glycyrrhetinic acid with polyalcohol and is dissolved with 95% full gear alcohol, the glycyrrhetinic acid and 95% full gear alcohol Weight ratio be 1:10.
- 4. a kind of preparation method of the creams containing glycyrrhetinic acid as claimed in claim 3, it is characterised in that: institute in step 3) The glycyrrhetinic acid stated is that glycyrrhetinic acid propylene glycol or butanediol or pentanediol disperse with disperse polyol, is evenly stirred until nothing Agglomeration.
- 5. a kind of preparation method of the creams containing glycyrrhetinic acid as claimed in claim 3, it is characterised in that: institute in step 4) The gradient homogenization stated is speed of agitator 45-60r/min, and processing condition is 3000r/min homogeneous 2-5min, 3500r/min Homogeneous 2-5min, 4000r/min homogeneous 5-10min.
- 6. a kind of preparation method of the creams containing glycyrrhetinic acid as claimed in claim 3, it is characterised in that: step 5), step It is rapid 6) described in homogenization be speed of agitator 45-60r/min, processing condition be 3000r/min homogeneous 2-5min.
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2017
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105902446A (en) * | 2016-06-15 | 2016-08-31 | 广东芭薇生物科技股份有限公司 | Anti-allergy skin care cream and preparing method thereof |
| CN106236656A (en) * | 2016-08-30 | 2016-12-21 | 湖南省雅迭香科技有限公司 | A kind of Herba Rosmarini Officinalis compacts eye cream |
| CN106727021A (en) * | 2017-01-10 | 2017-05-31 | 广州英姿源生物科技有限公司 | A kind of photon peptide combination preparation for skin repair maintenance and preparation method thereof |
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