CN109745142B - Novel quantitative aerosol administration device for rats and mice - Google Patents
Novel quantitative aerosol administration device for rats and mice Download PDFInfo
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- CN109745142B CN109745142B CN201910166447.9A CN201910166447A CN109745142B CN 109745142 B CN109745142 B CN 109745142B CN 201910166447 A CN201910166447 A CN 201910166447A CN 109745142 B CN109745142 B CN 109745142B
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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Abstract
The invention discloses a novel quantitative aerosol administration device for rats and mice, which comprises a breathing mask and a storage tank, wherein the breathing mask is of a truncated cone-shaped structure, the middle part of the upper bottom of the breathing mask is provided with an air inlet, the upper bottom is communicated with an inner cavity at one end of the storage tank through a connecting piece, and the air inlet is provided with a one-way valve for air suction to enter; the middle part of the side surface of the breathing mask is provided with an air outlet, and a one-way valve for discharging air is arranged at the air outlet; the breathing mask is an elastic mask which can completely wrap the heads of the big and the small mice and is relatively attached to the heads and the nose ends of the big and the small mice; an air inlet communicated with the inner cavity of the storage tank is arranged on the other end of the storage tank, and a gas pushing control device capable of reciprocating along the inner cavity of the storage tank is arranged in the storage tank. The device is simple and convenient to operate, quantitative and controllable, can meet the requirements of experimental research and application in animals subjected to inhalation administration, and can be widely applied to scientific researches such as sanitation, respiratory medicine and the like.
Description
Technical Field
The invention relates to an aerosol inhalation drug delivery device, in particular to a novel quantitative aerosol drug delivery device for rats and mice.
Background
Inhalation treatment belongs to local medication, and the medicine can directly reach a lesion part without blood circulation, and has the characteristics of small medicine dosage, higher medicine amount inhaled into the lung, long medicine deposition time, good safety and the like. At present, aerosol administration devices are various, and common use methods include directly using aerosol for drug absorption, an aerosol adding and absorbing auxiliary device, an aerosol adding and storing aerosol tank for drug absorption and the like. However, most of the current aerosol inhalation devices are designed for human beings and are not convenient to be directly applied to experimental animals. The respiratory drug administration device required by the animal body experiment in the research and development of the aerosol new drug and the pharmacological experiment research process is still imperfect, and most of the respiratory drug administration devices are formed by placing small animals in an atomization container, so that the following problems exist: (1) The small animals are not limited in movement, and the atomization effect is possibly influenced because the small animals place the mouth and the nose at the hidden part of the limbs of the small animals or the position in the container where the aerosol is not easy to reach; (2) The atomized air flow is unevenly distributed in the container where the small animals are located, and the small animals at different positions have inconsistent inhalation fog quantity, so that the experimental effect is affected. In order to solve the above problems, it is needed to invent a quantitative inhalation administration device for large and small mice so as to meet the smooth proceeding of inhalation treatment efficacy experiments.
Chinese patent application CN 107582211A discloses a rodent inhalation self-administration system and method of use thereof. The device comprises a dosing box for accommodating rodents, wherein a left nose touch, a right nose touch, a cage lamp and an indicating device are arranged in the dosing box; the medicine atomizing device is provided with a pipeline for conveying atomized medicine into the medicine feeding box, the pipeline is connected with the medicine feeding box, and one end of the pipeline connected with the medicine feeding box is provided with a medicine feeding switch; the control system is connected with the medicine atomizing device, the medicine feeding switch, the left nose touch, the right nose touch, the cage lamp and the indicating device. The automatic drug delivery device realizes inhalation drug delivery through self drug-seeking behavior, thereby judging the dependence and withdrawal effect of addictive drugs and realizing the purpose of simulating inhalation route drug delivery. However, the device can realize effective drug administration by relying on animal foraging behavior to generate touch, is suitable for drug administration of addictive substances such as smoke, hemp, ice toxin and the like, has weak compliance to common drug animals, and influences normal use of the device.
Chinese patent CN 207253396U discloses a rodent aerosol inhalation device, which mainly consists of a drug delivery tube, an atomizing chamber, a feeding chamber and a rubber plug; the medicine delivery pipe is positioned above the atomizing chamber, one end of the medicine delivery pipe is a medicine inlet, and the other end is a sleeve; the sleeve consists of an inner pipe, an outer pipe and an exhaust pipe, wherein the inner pipe and the outer pipe form a structure with a closed top and an open bottom, and the outer pipe is fixedly connected with the atomizing chamber; the outside of the atomizing chamber is connected with 6 feeding chambers; one end of the feeding chamber is fixedly connected with the atomizing chamber, a feeding hole is formed in the joint, an animal entrance is formed in the other end of the feeding chamber, the animal entrance is detachably connected with the rubber plug in an inserting mode, the atomizing chamber is cylindrical, and a mechanical stirrer is arranged at the lower portion of the atomizing chamber. The device can enable animals to absorb medicines in a waking state, reduces the influence of the exposure of eyes, skin and other organs to the medicines on the absorption of the medicines, and has the defect that the medicine absorption amount of the animals cannot be controlled easily and the complete absorption of the medicines by the animals cannot be ensured.
Chinese patent CN 208447842U discloses a respiratory exposure device for breathing is dosed, including controller and aerosol generator, subsidence case and experimental animal incubator that link to each other in proper order through the pipeline, aerosol generator is used for generating experimental aerosol, and subsidence case is used for generating experimental aerosol, and experimental animal incubator is used for placing the animal that inhales toxicological experiment and uses, generates aerosol after the aerosol gets into subsidence case, and the aerosol is imported experimental animal incubator, and is provided with the flow valve on the pipeline between subsidence case and the experimental animal incubator, be provided with in the experimental animal incubator be used for real-time acquisition case aerosol concentration's sensor, flow valve and sensor all with controller communication connection. The sensor in the device can collect the concentration of the aerosol in the experimental animal incubator, and realizes automatic and accurate control of the concentration of the aerosol. However, compared with the device of the invention, the device is more complex, has high cost and long experiment time.
Disclosure of Invention
The invention aims to overcome the defects of the prior art, and provides a novel quantitative aerosol administration device for large and small mice, which is simple and convenient to operate, quantitative and controllable, can meet the requirements of experimental research and application in animals subjected to inhalation administration, and is widely applied to scientific researches such as sanitation, respiratory medicine and the like.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
the novel quantitative aerosol administration device for the big and small mice comprises a breathing mask and a storage tank, wherein the breathing mask is of a truncated cone-shaped structure, the middle part of the upper bottom of the breathing mask is provided with an air inlet, the upper bottom is communicated with an inner cavity at one end of the storage tank through a connecting piece, and the air inlet is provided with a one-way valve for air suction to enter; the middle part of the side surface of the breathing mask is provided with an air outlet, and a one-way valve for discharging air is arranged at the air outlet; the breathing mask is an elastic mask which can completely wrap the heads of the big and the small mice and is relatively attached to the heads and the nose ends of the big and the small mice; an air inlet communicated with the inner cavity of the storage tank is arranged on the other end of the storage tank, and a valve is arranged at the air inlet. The storage tank is internally provided with a gas pushing control device capable of reciprocating along the inner cavity of the storage tank, after medicine is sprayed, the air inlet is opened, in the animal breathing process, pressure difference is generated at two sides of the gas pushing control device, and the gas pushing control device can slide along the chute in the tank towards the direction of the breathing mask along with the pressure change at two sides of the gas pushing control device.
An opening with elastic bands is arranged on the lower bottom surface of the breathing mask.
The connecting piece is a connecting knob and comprises an external thread on the upper bottom and an internal thread on the storage tank matched with the external thread.
The storage tank is of a cylindrical structure.
A chute is arranged on the inner cavity wall of the storage tank along the length direction.
The gas pushing control device comprises a round gas pushing piece which can be tightly attached to the inner cavity wall of the storage tank, a bulge which is clamped in the chute and can reciprocate along the chute is arranged on the edge of the gas pushing piece, an aerosol inhaler placing opening communicated with the inner cavity of the storage tank is formed in the gas pushing piece, and a closing valve plate capable of closing and opening the aerosol inhaler placing opening is arranged on the outer end face of the gas pushing piece.
The upper part of the aerosol inhaler placing opening on the outer end surface of the gas pushing piece is also provided with a baffle plate.
The closing valve plate is eccentrically arranged on the gas pushing plate at the lower part of the aerosol inhaler placing opening through the pin shaft, a handle which can be buckled on the baffle plate is arranged on the closing valve plate, the closing valve plate can rotate along the pin shaft, and when the handle is buckled on the baffle plate, the closing valve plate can completely seal the aerosol inhaler placing opening.
In the invention, the breathing mask is an elastic mask, so that the heads of the large and small mice can be completely covered and are relatively attached to the heads and the nose ends of the large and small mice, and atomized gas leakage can be effectively prevented while the large and small mice are atomized and inhaled. The air inlet is positioned in the middle of one end of the mask and is an inlet for sucking aerosol for small animals, and a one-way air suction control valve is arranged for controlling one-way air suction. The air outlet is positioned on the side surface of the face mask and is provided with a one-way control valve, and the exhaled air is directly exhausted.
The storage tank is an intermediate device for connecting the aerosol inhaler and the breathing mask, and when the experimental animal inhales medicines, the external air pushes the control device to move forward along with the reduction of medicine carrying gas in the storage tank.
The beneficial effects of the invention are as follows:
the device provided by the invention can regulate and control the dosage of aerosol, ensure that experimental animals inhale medicines completely, can obtain reliable and stable experimental results, and provide convenience for smooth experiment.
The mask part designed by the invention is integrally formed by adopting high-elasticity silica gel material, has good facial tightness, prevents medicine leakage and ensures the smooth performance of experiments.
The one-way air inlet valve is arranged at the joint of the breathing mask and the storage tank, and the one-way air outlet valve is arranged at the lower end of the breathing mask, so that one-way circulation of air is ensured. Meanwhile, the storage tank is provided with the gas unidirectional propulsion control device, so that the experimental animals are guaranteed to completely inhale the medicine carrying gas, and the reliability of experimental data is improved.
Drawings
FIG. 1 is a schematic diagram of the structure of one embodiment of the present invention;
FIG. 2 is a schematic diagram of a gas propulsion control apparatus;
the breathing mask comprises a breathing mask body, a storage tank, a connecting port A, a connecting port B, a mask tightness opening 5, a gas outlet 6, a one-way gas outlet valve 7, a one-way gas suction valve 8, a connecting knob 9, a gas pushing control device 10, a gas inlet 11, a valve 12, a valve 13, a chute 16, a closing valve plate 17, a baffle plate 18, an aerosol inhaler placing port 19 and a gas pushing plate.
Detailed Description
The invention will be further described with reference to the drawings and examples.
The structures, proportions, sizes, etc. shown in the drawings attached hereto are for illustration purposes only and are not intended to limit the scope of the invention, which is defined by the claims, but rather by the claims. Also, the terms such as "upper," "lower," "left," "right," "middle," and "a" and the like recited in the present specification are merely for descriptive purposes and are not intended to limit the scope of the invention, but are intended to provide relative positional changes or modifications without materially altering the technical context in which the invention may be practiced.
As shown in fig. 1 and 2, the novel quantitative aerosol administration device for rats and mice comprises a breathing mask 1 and a storage tank 2, wherein the breathing mask 1 is in a truncated cone structure, the middle part of the upper bottom of the breathing mask is provided with an air inlet, the upper bottom is communicated with an inner cavity at one end of the storage tank 2 through a connecting piece, and the air inlet is provided with a one-way suction valve 8 for suction to enter; an air outlet 6 is formed in the middle of the side face of the breathing mask 1, and a one-way air outlet valve 7 for discharging air is arranged at the air outlet 6; the breathing mask 1 is an elastic mask which can completely wrap the heads of a large mouse and a small mouse and is relatively attached to the heads and the nose ends of the large mouse; the other end of the storage tank 2 is provided with an air inlet 11 communicated with the inner cavity of the storage tank; the air inlet 11 is provided with a valve 12, and the storage tank 2 is provided with a gas pushing control device 11 capable of reciprocating along the inner cavity of the storage tank. After the medicine is injected, the air inlet 11 is opened, and in the animal breathing process, pressure difference is generated at two sides of the air pushing control device 11, and the air pushing control device 11 can slide along the chute 13 in the tank towards the breathing mask 1 along with the pressure change at two sides of the air pushing control device 11.
An opening 5 with elastic bands is arranged on the lower bottom surface of the breathing mask 1. The connecting piece is a connecting knob 9, and comprises an external thread on the upper bottom and an internal thread on the storage tank 2 matched with the external thread.
The storage tank 2 has a cylindrical structure. A chute 13 is arranged on the inner cavity wall of the storage tank along the length direction.
The gas pushing control device 10 comprises a circular gas pushing piece 19 which can be tightly attached to the inner cavity wall of the storage tank, a bulge which is clamped in the chute 13 and can reciprocate along the chute is arranged on the edge of the gas pushing piece 19, an aerosol inhaler placing opening 18 which is communicated with the inner cavity of the storage tank is formed in the gas pushing piece 19, and a closing valve plate 16 which can close and open the aerosol inhaler placing opening 18 is arranged on the outer end face of the gas pushing piece 19.
The upper part of the aerosol inhaler placing opening 18 on the outer end surface of the gas pushing piece 19 is also provided with a baffle 17. The closing valve plate 16 is eccentrically arranged on the air pushing plate 19 at the lower part of the aerosol inhaler placing opening 18 through a pin shaft, a handle which can be buckled on the baffle 17 is arranged on the closing valve plate 16, the closing valve plate 16 can rotate along the pin shaft, and when the handle is buckled on the baffle 17, the closing valve plate 16 can completely seal the aerosol inhaler placing opening 18.
According to the invention, the breathing mask is an elastic mask, so that the heads of the rats and the mice can be completely covered, the breathing mask can be relatively attached to the heads and the nose ends of the rats and the mice, and the atomized gas can be effectively prevented from leaking while the rats and the mice are atomized and inhaled. The air inlet is positioned in the middle of one end of the mask and is an inlet for sucking aerosol for small animals, and a one-way air suction control valve is arranged for controlling one-way air suction. The air outlet is positioned on the side surface of the face mask and is provided with a one-way control valve, and the exhaled air is directly exhausted.
The experimental animal is fixed on the belt to breathe the mask 1, the rotary connection knob 9 is connected with the storage tank 2, and the air inlet 11 is closed. The aerosol inhaler ejection port extends into the aerosol inhaler placement port 18 at the B connection port 4. The metered dose aerosol is sprayed, the aerosol inhaler is drawn out, the closing valve plate 16 is rotated to be fixed to the baffle 17, and the sealing of the aerosol inhaler placing opening 18 is realized. The experiment begins, opens air inlet 11, and experimental animal spontaneously breathes, and in big mouse breathing process, the gaseous gradual reduction in respirator and the storing jar, and storing jar gas promotes controlling means both sides and forms pressure differential, and outside gas promotes the gaseous pushing device to remove to A connector 3, and when gas pushing controlling means 10 reached A connector 3, the experiment ended.
In the whole experimental process, the unidirectional circulation of gas is ensured, meanwhile, the storage tank is provided with the unidirectional gas pushing control device, so that the experimental animals are ensured to completely inhale the medicine carrying gas, and the reliability of experimental data is improved.
While the foregoing description of the embodiments of the present invention has been presented in conjunction with the drawings, it should be understood that it is not intended to limit the scope of the invention, but rather, it is intended to cover all modifications or variations within the scope of the invention as defined by the claims of the present invention.
Claims (7)
1. The novel quantitative aerosol administration device for the big and small mice is characterized by comprising a breathing mask and a storage tank, wherein the breathing mask is of a truncated cone-shaped structure, the middle part of the upper bottom of the breathing mask is provided with an air inlet, the upper bottom is communicated with the inner cavity at one end of the storage tank through a connecting piece, and the air inlet is provided with a one-way valve for air suction to enter; the middle part of the side surface of the breathing mask is provided with an air outlet, and a one-way valve for discharging air is arranged at the air outlet; the breathing mask is an elastic mask which can completely wrap the heads of the big and the small mice and is relatively attached to the heads and the nose ends of the big and the small mice; an air inlet communicated with the inner cavity of the storage tank is arranged at the other end of the storage tank, and a gas pushing control device capable of reciprocating along the inner cavity of the storage tank is arranged in the storage tank;
a chute is arranged on the inner cavity wall of the storage tank along the length direction; the gas pushing control device comprises a round gas pushing piece which can be tightly attached to the inner cavity wall of the storage tank, a bulge which is clamped in the chute and can reciprocate along the chute is arranged on the edge of the gas pushing piece, an aerosol inhaler placing opening communicated with the inner cavity of the storage tank is formed in the gas pushing piece, and a closing valve plate capable of closing and opening the aerosol inhaler placing opening is arranged on the outer end face of the gas pushing piece;
in the breathing process of the big and small mice, the gas in the breathing mask and the storage tank is gradually reduced, the pressure difference is formed at two sides of the storage tank gas pushing control device, and the external gas promotes the gas pushing device to move towards the breathing mask.
2. The novel dosing device for large and small mouse quantitative aerosol according to claim 1, wherein the lower bottom surface of the breathing mask is provided with an opening with elastic bands.
3. The novel dosing device for large and small mouse quantitative aerosol according to claim 1, wherein the connecting piece is a connecting knob and comprises an external thread on an upper bottom and an internal thread on a storage tank matched with the external thread.
4. The novel dosing device for large and small mouse quantitative aerosol according to claim 1, wherein a valve is arranged at the air inlet.
5. The novel dosing device for large and small mouse quantitative aerosol according to claim 1, wherein the storage tank is of a cylindrical structure.
6. The novel dosing device for aerosol administration of rats and mice according to claim 1, wherein a baffle is further provided on the upper part of the opening for placing the aerosol inhaler on the outer end surface of the gas pushing piece.
7. The novel quantitative aerosol administration device for rats and mice according to claim 6, wherein the closing valve plate is eccentrically arranged on the air pushing plate at the lower part of the placing opening of the aerosol inhaler through a pin shaft, a handle which can be buckled on the baffle plate is arranged on the closing valve plate, the closing valve plate can rotate along the pin shaft, and when the handle is buckled on the baffle plate, the closing valve plate can completely seal the placing opening of the aerosol inhaler.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910166447.9A CN109745142B (en) | 2019-03-06 | 2019-03-06 | Novel quantitative aerosol administration device for rats and mice |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910166447.9A CN109745142B (en) | 2019-03-06 | 2019-03-06 | Novel quantitative aerosol administration device for rats and mice |
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| CN109745142A CN109745142A (en) | 2019-05-14 |
| CN109745142B true CN109745142B (en) | 2023-08-11 |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112704578A (en) * | 2020-12-31 | 2021-04-27 | 西安医学院 | Adjustable and controllable atomization inhalation device for small animals |
| CN113143534B (en) * | 2021-05-25 | 2024-06-18 | 上海威泽健康科技有限公司 | One-way breather valve and animal auxiliary dosing respirator with same |
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